Crohn’s Disease: Radiological Features and Clinical-Surgical Correlations PDF
Preview Crohn’s Disease: Radiological Features and Clinical-Surgical Correlations
Giuseppe Lo Re Massimo Midiri Editors Crohn’s Disease Radiological Features and Clinical-Surgical Correlations 123 Crohn’s Disease Giuseppe Lo Re (cid:129) Massimo Midiri Editors Crohn’s Disease Radiological Features and Clinical-S urgical Correlations Editors Giuseppe Lo Re Massimo Midiri Radiology Department University of Palermo Policlinico Paolo Giaccone Radiology Department Palermo Policlinico Paolo Giaccone Italy Palermo Italy ISBN 978-3-319-23065-8 ISBN 978-3-319-23066-5 (eBook) DOI 10.1007/978-3-319-23066-5 Library of Congress Control Number: 2015956406 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com) Foreword C rohn’s disease is a chronic pathology that is very diffi cult to understand and to diagnose especially in the early stages, resulting in a signifi cant deteriora- tion in the patients’ quality of life. In the past, this disease had a higher incidence in the northern Europe countries. Recently we have seen an increase of cases in the Mediterranean area, probably due to environmental factors and changes in lifestyle, becom- ing increasingly challenging not only for radiologists but also for clinicians. This book deals thoroughly with Crohn’s disease, analyzing the different clinical, diagnostic, and therapeutic aspects. The purpose is to provide a global view of the pathology, necessary to understand the disease in its entirety and in its complexity. In fact these patients cannot be approached in “watertight compartments,” but the partnership between the clinician, the radiologist, and the surgeon is more necessary than ever, in order to achieve the most appropriate treatment for each case. Because of the different presentations, often treacherous and misleading, and the complexity of the several extraintestinal manifestations, only an inte- grated clinical-radiological approach can lead to proper patient management. I n this scenario, radiological imaging plays an important role, providing various diagnostic options based on the most modern technology. Every diag- nostic modality can be exploited differently depending on the various stages of the disease. The authors involved in this project can boast an internationally recog- nized expertise, arising from years of research focused on to the study of Crohn’s disease. The result of their contribution brings to a complete and integrated text, containing the latest knowledge in this fi eld, providing an extremely useful tool for anyone who decides to tackle this disease. Dott. Gian Andrea Rollandi Direttore S.C. Radiodiagnostica Coordinatore Scientifi co E.O. Ospedali Galliera Via Volta 8, 16132 Genova, Italy v Acknowledgments To my wife Maria Cristina, my daughter Roberta Maria, and to my parents. Giuseppe Lo Re To my wife Anna and to my sons Federico and Mauro. Massimo Midiri vii Contents 1 Epidemiological Aspects of Crohn’s Disease . . . . . . . . . . . . . 1 Francesco Vitale 2 Clinical Presentation of Crohn’s Disease . . . . . . . . . . . . . . . . 7 Marta Mazza , Maria Giovanna Cilluffo , and Maria Cappello 3 Laboratory Tests in Crohn’s Disease . . . . . . . . . . . . . . . . . . . 15 Gaetano C. Morreale , Maria Cappello , and Antonio Craxì 4 Course of Crohn’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Andrea Affronti , Ambrogio Orlando , and Mario Cottone 5 Diagnostic and Therapeutic Role of Endoscopy in Crohn’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Gianfranco Cocorullo , Nicola Falco , Tommaso Fontana , Roberta Tutino , Sebastiano Bonventre , Francesco D’Arpa , and Gaspare Gulotta 6 Medical Treatment of Perianal Crohn’s Disease . . . . . . . . . . 49 Ambrogio Orlando , Sara Renna , Gaspare Solina , and Mario Cottone 7 Standard Therapeutic Approach and New Therapies . . . . . . 59 Marco Mendolaro , Anna Viola , and Maria Cappello 8 Current Status of Imaging in Small and Large Bowel Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 Gian Andrea Rollandi and Luca Cevasco 9 Conventional Radiology in the Evaluation of the Small Bowel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Giuseppe Lo Re , Federica Vernuccio , Dario Picone , Federico Midiri , Maria Cristina Galfano , Sergio Salerno , Roberto Lagalla , and Massimo Midiri 10 US in Inflammatory Bowel Diseases . . . . . . . . . . . . . . . . . . . . 91 Di Grezia Graziella , Gatta Gianluca , Berritto Daniela , Iacobellis Francesca , Reginelli Alfonso , Gagliardi Giuliano , Grassi Roberta , and Cappabianca Salvatore ix
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