Critical dietary factors in cancer chemoprevention

376 Pages·2016·5.79 MB·English

by  Ahmad

Mohammad Fahad Ullah · Aamir Ahmad
Editors
Critical Dietary
Factors in Cancer
Chemoprevention
Critical Dietary Factors in Cancer Chemoprevention
ThiSisaFMBlankPage
Mohammad Fahad Ullah (cid:129) Aamir Ahmad
Editors
Critical Dietary Factors in
Cancer Chemoprevention
Editors
MohammadFahadUllah AamirAhmad
PrinceFahdResearchChair DepartmentofPathology
DepartmentofMedicalLaboratoryTechnology KarmanosCancerInstitute
FAMS,UniversityofTabuk WayneStateUniversity
Tabuk,SaudiArabia Detroit,Michigan
USA
ISBN978-3-319-21460-3 ISBN978-3-319-21461-0 (eBook)
DOI10.1007/978-3-319-21461-0
LibraryofCongressControlNumber:2015952214
SpringerChamHeidelbergNewYorkDordrechtLondon
©SpringerInternationalPublishingSwitzerland2016
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Foreword
Thisbookentitled“Criticaldietaryfactorsincan-
cerchemoprevention”isacomprehensiveattempt
tohighlightnovelopportunitiesfortheprevention
of neoplastic diseases by dietary means. Recently
emerging evidence has revealed that long-term
lifestyle factors including dietary habits signifi-
cantlyinfluencecancerdevelopment,progression,
and response to therapy. Modification of dietary
habits to include dietary factors with evidence of chemopreventive properties via
the modulation of intracellular signaling pathways as regular components of diet
has thus been conceived tobe a potential strategy to lower the risk and burden of
cancer incidence. Furthermore, these dietary factors also provide leads to potent
therapeuticdrugswithelevatedmarginsofsafety.Thisbookprovidesanupdateon
contemporaryresearchinthisfieldwithanimpressivegroupofauthors.Aunique
feature of the book is that along with regular chapters, there are expert opinions
fromrenownedauthors,astrategythatenhancestheimpactoftheknowledgeand
informationemanatingfromthiscompilation.
Icommendtheeditors,Dr.MohammadFahadUllahandDr.AamirAhmadand
all the contributors, for this significant piece of work that encourages the engage-
mentofdietaryfactorsasaneffectiveparadigmincancerprevention.
Knoxville,TN,USA HildegardM.Schuller,D.V.M.,Ph.D
v
ThiSisaFMBlankPage
Preface
Thesuccessofscientificresearchontheladderofvalidationisperfectedwhenthe
ideatraversestheuntroddenpathanddeliversthedesiredbenefittothecommunity
of people. This book “Critical dietary factors in cancer chemoprevention” is an
attemptofarchivingafewsuchideasinscientificandpublicdomain.Wecommend
SpringerPublishersinprovidingthefoundationforthisendeavorandentrustingus
withthetaskofmanagingandeditingthecurrentvolumeofthecompilationthatwe
presentbeforetheaudience.
Precisely,thevolumecontainstwosections.SectionIintroducestheimportance
ofthe topic ofthis bookthrough the opinionofthree renownedexperts who have
immensely contributed to the area of dietary factors in prevention of cancer for
morethanfourdecades.ThisisfollowedbySectionIIwhichhas15chaptersthat
areintendedtohighlightthesignificanceofdietaryfactorsinthepremisesofcancer
chemopreventionaspartofprophylactic,therapeutic,oradjuvantinterventions.
SectionI:Curcumin,aconstituentofturmericwhichisusedasspiceinfoodand
anti-inflammatory agent in traditional medicines, has been known for long to
possess anticancer properties. In the first expert opinion, Dr. Sarkar provides an
updateonanovelsyntheticanalogueofcurcumin,CDF,withregardtoitsenhanced
efficacyagainstcancer.Thisreflectsthatthedietaryagentshavethepotentialtonot
only provide preventive strategy as part of regular consumption but also have the
potentialtoactasleadcompoundforthedevelopmentoftherapeuticinterventions.
The second opinion comes from Dr. Mukhtar, which advocates the synergism of
bioactivecompoundsasacocktailinthedevelopmentofpersonalizedapproachto
cancerchemoprevention.Dr.Hadicontributesthethirdexpertopinionwhereonhe
explains the delicate balance of the contrasting properties of bioactive molecules
actingasboththeantioxidantsandprooxidantsandhowthesecouldbeutilizedin
theirpotentialagainstcancer.
vii
viii Preface
Section II: Chapter “Phytocomplexity: the key to rational chemoprevention”
provides an excellent presentation of a concept that links the significance of
phytocomplexityofwholefruitsorvegetablesinharvestingthedesiredchemopre-
ventive efficacy incancerprevention. Chapter “The ketogenic diet asan adjuvant
therapyforbraintumorsandothercancers”preciselydealswithmetabolictherapy
wheretheauthorssuggesttheapplicationofketogenicdietasanadjuvanttherapyin
starvingthecancercellsofenergy.Chapter“Theroleoforganosulfurcompounds
derived from Allium vegetables in cancer prevention and therapy” explores the
anticancerpotentialofbioactivecompoundsoforganosulfurnature,emergingasa
promisingcancerchemopreventivestrategy.Chapter“EpigeneticImpactofBioac-
tiveDietaryCompoundsinCancerChemoprevention”deliberatestheinfluenceof
dietaryfactorsinreversingtheepigeneticeventsfollowingtheprocessofneoplastic
transformation. Chapters “Potential for sesame seed-derived factors to prevent
colorectal cancer” and “Progress in the development of black seed derived anti-
cancer agents” present an overview of the anticancer potential of the bioactive
constituentsofsesameseedandblackseed,respectively,andprovidemechanism-
basedinsights.Chapters“Soyisoflavonesinthebreastcancerrisk:frompreclinical
findings to clinical strategy” and “Pharmacological role of dietary polyphenols in
prostate cancer chemoprevention” focus on certain dietary agents with critical
value in the prevention of breast cancer and prostate cancer, respectively.
Chapter “Effects of garcinol from kokum (Garcinia indica) on the prevention and
treatment ofcancer” gives an accountof nutraceutical garcinol and its chemopre-
ventiveefficacyagainstcancer.Chapters“Modulationofkeysignalingpathwaysin
cancer cells bydietaryfactors”and “Pivotal roleofchemokine receptor signaling
axis and natural bioactive chemopreventive agents inmetastasis ofbreast cancer”
demonstratethecomplexnatureofcellularsignalingincancercellsandtheability
of dietary compounds to interfere with these pathways. Chapter “Dietary factors
may influence the clinical outcome of chemotherapy in cancer multidrug resis-
tance” discusses the current interest in dietary molecules with respect to their
potential role in addressing the drug resistance in cancer. Chapter “The role of
energybalanceincancerprevention”pointstotheneedofenergy-balanceddietary
intake in reducing the risk of cancer. Chapter “Dietary/environmental factors and
breast cancer” reviews the significance of dietary fats and Mediterranean diet in
relationtobreastcancerrisk.Finally,chapter“Probioticbacteriainpatientstreated
withchemotherapyandradiationtherapy”addressestheemergingroleofprobiotics
inthemanagementoftoxicresponsesassociatedwithchemo-andradiationtherapy
incancerpatients.
Weexpressourgratitudetoalltheauthorsforvaluablecontributionfromaround
the globe. It is their willingness to share their onerous experiences which has
empowered us to bring forth this piece of scientific literature. We appreciate the
support of Dr. Beatrice Menz (Senior Editor, Springer Basel) for working out the
procedural framework of our book proposal. Fortunately, we had Ms. Kay Stoll
(SpringerProduction),asanexcellentprojectcoordinator,whoprovidedthebasic
Preface ix
skeleton of strength that is required for any attractive and meaningful academic
production.WeareindeedhonoredtohaveProf.HildeguardM.Schullerintroduc-
ingthesubstanceofthebookintheforeword.
Lastly, wewishthattheaudience willlikethecontentsofthisbookanditwill
takeusastepforwardinunderstandingthecriticalnatureoflifestyleissuesvis–(cid:1)avis
dietaryhabitsinreducingtheriskofchronicdiseasessuchascancer.
Tabuk,SaudiArabia MohammadFahadUllah
Detroit,MI,USA AamirAhmad