Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288

299 Pages·2008·12.08 MB·English

by  Novartis Foundation(eds.)

Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288, Volume 288.
Edited by Gregory Bock and Jamie Goode
Copyright  Novartis Foundation 2007. ISBN: 978-0-470-06092-6
CORTICAL DEVELOPMENT:
GENES AND GENETIC
ABNORMALITIES
The Novartis Foundation is an international scientifi c and educational
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as the Ciba Foundation, it was established in 1947 by the CIBA company of
Basle, which merged with Sandoz in 1996, to form Novartis. The Foundation
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Novartis Foundation Symposium 288
CORTICAL
DEVELOPMENT:
GENES AND GENETIC
ABNORMALITIES
Copyright © Novartis Foundation 2007
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Novartis Foundation Symposium 288
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Contents
Symposium on Cortical development: genes and genetic abnormalities, held at the Novartis
Foundation, London, 6–8 February 2007
Editors: Gregory Bock (Organizer) and Jamie Goode
This symposium is based on a proposal made by Zoltán Molnár
John G. Parnavelas Chair’s introduction 1
Bradley J. Molyneaux, Paola Arlotta and Jeffrey D. Macklis Molecular
development of corticospinal motor neuron circuitry 3
Discussion 15
Gordon Fishell Perspectives on the developmental origins of cortical
interneuron diversity 21
Discussion 35
Pasko Rakic, Kazue Hashimoto-Torii and Matthew R. Sarkisian Genetic
determinants of neuronal migration in the cerebral cortex 45
Discussion 53
Stephen C. Noctor, Veronica Martinez-Cerdeño and Arnold R. Kriegstein
Neural stem and progenitor cells in cortical development 59
Discussion 73
Teresa H. Chae and Christopher A. Walsh Genes that control the size of
the cerebral cortex 79
Discussion 91
General discussion I 96
Vicki Hammond, Joanne Britto, Eva So, Holly Cate and Seong-Seng Tan
Control of cortical neuron layering: lessons from mouse chimeras 99
Discussion 108
v
vi CONTENTS
Fujio Murakami, Daisuke Tanaka, Mitsutoshi Yanagida and
Emi Yamazaki Intracortical multidirectional migration of cortical
interneurons 116
Discussion 125
Libing Zhou, Fadel Tissir and André M. Goffi net The atypical cadherin
Celsr3 regulates the development of the axonal blueprint 130
Discussion 134
Dennis D. M. O’Leary , Shen-Ju Chou, Tadashi Hamasaki,
Setsuko Sahara, Akihide Takeuchi, Sandrine Thuret and
Axel Leingärtner Regulation of laminar and area patterning of mammalian
neocortex and behavioural implications 141
Discussion 159
Jeremy A. Cholfi n and John L. R. Rubenstein Genetic regulation of
prefrontal cortex development and function 165
Discussion 173
Henry Kennedy, Rodney Douglas, Kenneth Knoblauch and
Colette Dehay Self-organization and pattern formation in
primate cortical networks 178
Discussion 195
Nobuhiko Yamamoto, Takuro Maruyama, Naofumi Uesaka,
Yasufumi Hayano, Makoto Takemoto and Akito Yamada Molecular
mechanisms of thalamocortical axon targeting 199
Discussion 208
Zoltán Molnár, Anna Hoerder-Suabedissen, Wei Zhi Wang,
Jamin DeProto, Kay Davies, Sheena Lee, Erin C. Jacobs,
Anthony T. Campagnoni, Ole Paulsen, Maria Carmen Piñon and
Amanda F. P. Cheung Genes involved in the formation of
the earliest cortical circuits 212
Discussion 224
Michael Piper, Amber-Lee S. Dawson, Charlotta Lindwall, Guy Barry,
Céline Plachez and Linda J. Richards Emx and Nfi genes regulate cortical
development and axon guidance in the telencephalon 230
Discussion 242
CONTENTS vii
Paul J. Harrison Schizophrenia susceptibility genes and their
neurodevelopmental implications: focus on neuregulin 1 246
Discussion 255
Peter B. Crino Focal brain malformations: a spectrum of disorders along the
mTOR cascade 260
Discussion 272
Final discussion 276
Index of contributors 282
Subject index 284
Participants
Colin Blakemore Medical Research Council, 20 Park Crescent, London W1B
1AL, UK
Jamel Chelly Institut Cochin (IC), Département de Génétique et Pathologie
Moléculaire, Equipe de Génétique et Physiopathologie des Retards Mentaux, 24,
rue du Faubourg St Jacques, F-75014 Paris, France
Peter B. Crino Hospital of the University of Pennsylvania, Department of Neu-
rology, 3 West Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Kay Davies MRC Functional Genetics Unit, Department of Physiology, Anatomy
and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Gordon Fishell NYU School of Medicine, Smilow Neuroscience Program and
the Department of Cell Biology, 5th Smilow Bldg, 522 First Avenue, New York,
NY 10016, USA
Gaëlle Friocourt-Masse Laboratoire de Genetique Moléculaire et d’Histocom-
patibilité, INSERM U613, 46 rue Félix Le Dantec, 29200 Brest, France
André M. Goffi net University of Louvain Medical School, Developmental Neu-
robiology Unit, 73 avenue E. Mounier, Box DENE 7382, B-1200 Brussels,
Belgium
François Guillemot Division of Molecular Neurobiology, NIMR, Mill Hill,
London NW7 1AA, UK
Paul J. Harrison Neurosciences Building, Department of Psychiatry, Warneford
Hospital, University of Oxford, Oxford OX3 7JX, UK
Robert Hevner Department of Pathology, University of Washington, Harbor-
view, Box 359791, Seattle, WA 98104-9791, USA
David Keays St Anne’s College, University of Oxford, Oxford OX2 6HS, UK
ix
x PARTICIPANTS
Henry Kennedy Stem Cell and Brain Research Institute, INSERM U846, 18
avenue Doyen Lépine, F-69675 Bron Cedex, France
Arnold R. Kriegstein Institute for Regeneration Medicine, UCSF School of
Medicine, 513 Parnassus Avenue, HSW 1201, Campus Box 0525, San Francisco,
CA 94143-0525, USA
Jeffrey D. Macklis Harvard Medical School, Massachusetts General Hospital,
MGH-HMS Center for Nervous System Repair, 50 Blossom Street, EDR 410,
Boston, MA 02114, USA
Antonello Mallamaci Laboratory of Cerebral Cortex Development, SISSA—
Neurobiology Sector, Research Area of Basovizza, Box Q1, Floor 1, Basovizza S.
S. 14, Km 163.5, I-34012 Trieste, Italy
Zoltán Molnár Department of Physiology, Anatomy and Genetics, Le Gros Clark
Building, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Fujio Murakami Laboratory of Neuroscience, Graduate School of Frontier
Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan
Dennis D. M. O’Leary Molecular Neurobiology Laboratory, The Salk
Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA
92037, USA
John G. Parnavelas (Chair) Department of Anatomy and Developmental Biology,
Anatomy Building, University College London, Gower Street, London WC1E
6BT, UK
David Price Biomedical Sciences, Hugh Robson Building, University of
Edinburgh, 1 George Square, Edinburgh EH8 9XD, UK
Pasko Rakic Department of Neurobiology, Yale University School of Medicine,
333 Cedar Street, SHM C303, PO Box 208001, New Haven, CT 06520-8001,
USA
Linda J. Richards The University of Queensland, School of Biomedical Sciences
and The Queensland Brain Institute, Department of Anatomy and Developmental
Biology, Otto Hirschfeld Building (81), Brisbane, QLD 4072, Australia
John L. R. Rubenstein University of California at San Francisco, Department
of Psychiatry, 1550 4th Street, 2nd Floor South, Room RH 284C, Box 2611, San
Francisco, CA 94143-2611, USA
PARTICIPANTS xi
Anastassia Stoykova Max Planck Institute for Biophysical Chemistry, Am
Fassberg 11, 37077 Göttingen, Germany
Seong-Seng Tan Howard Florey Institute, Cnr. Royal Parade and Grattan Street,
University of Melbourne, Parkville VIC 3010, Australia
Christopher A. Walsh Division of Genetics, Children’s Hospital Boston, Howard
Hughes Medical Institute, BIDMC, Harvard Medical School, 77 Avenue Louis
Pasteur, Boston, MA 02115, USA
Adam Wilkins BioEssays, 10/11 Tredgold Lane, Napier Street, Cambridge CB1
1HN, UK
Michael Wilson University of New Mexico, Department of Neurosciences, Basic
Medical Sciences Building, Albuquerque, NM 87131-5223, USA
Nobuhiko Yamamoto Neuroscience Laboratories, Graduate School of Frontier
Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan