Correlates between attention-deficit/hyperactivity disorder dimensional behavioral scales and urinary neurochemical excretion PDF
Preview Correlates between attention-deficit/hyperactivity disorder dimensional behavioral scales and urinary neurochemical excretion
Permission to photocopy or microfilm processing of this thesis for the purpose of individual scholarly consultation or reference is hereby granted by the author. This permission is not to be interpreted as affecting publication of this work or otherwise placing it in the public domain, and the author reserves all rights of ownership guaranteed under common law protection of unpublished Digitized by the Internet Archive in 2017 with funding from Arcadia Fund https://archive.org/details/correlatesbetweeOOyang Correlates between Attention-Deficit/Hyperactivity Disorder Dimensional Behavioral Scales and Urinary Neurochemical Excretion A Thesis Submitted to the Yale University School of Medicine in Partial Fulfillment of the Requirements for the Degree of Doctor of Medicine by Benson Pin-Sheng Yang 2001 YALE MEDICAL LIBRARY AUG 2 4 2001 (\Ape I Lila TII3 f v/z CORRELATES BETWEEN ATTENTION-DEFICIT/HYPERACTIVITY DISORDER DIMENSIONAL BEHAVIORAL SCALES AND URINARY NEUROCHEMICAL EXCRETION. Benson P. Yang, John M. Holahan, George M. Anderson, and Bennett A. Shaywitz. Department of Pediatrics, Yale University, School of Medicine, New Haven, CT. Attention-deficit/hyperactivity disorder (ADHD) is a neurobiological condition characterized by inattention, impulsivity, and hyperactivity. This study of 251 boys attempts to establish biological correlates of the core features of ADHD through measurable differences in sympathoadrenomedullary function. Behavioral constructs based on recent DSM notions of ADHD were empirically derived from factor analysis of several assessment instruments. The constructs were examined as dimensional variables to determine whether certain behavioral profiles were predictive of catecholamine or cortisol excretion. Data from parents and teachers were analyzed separately to examine the relationship between informant source and urinary neurochemical levels. Bivariate analyses revealed that reduced urinary epinephrine excretion was significantly correlated with the DSM-IV-based inattention scale. These correlations were stronger when children were rated by teachers (r=-0.213, p=0.001) than when they were rated by parents (r=-0.145, p=0.022). Furthermore, significant negative correlations were found between the DSM-IV-based inattention scales and urinary norepinephrine excretion, but only for teacher-completed ratings (r=-0.177, p=0.005). Analysis using a multiple regression model reaffirmed the results found with bivariate correlations. Overall, measurements of neurochemical excretion support the construct validity of the DSM-IV characterization of ADHD which separates inattention and impulsivity over the DSM-III characterization which combines these constructs.
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