Table Of Content

Controlled Clinical Trials DESIGN, METHODS, AND ANALYSIS Official Journal of the Society for Clinical Trials Volume 15, Number 1, 1994 CHARLES L. WITTE, MARLYS H. WITTE, AND ANN KERWIN Suspended Judgement Ignorance and the Process of Learning and Discovery in Medicine JANET WITTES Introduction: From Clinical Trials to Clinical Practice—Four Papers from a Plenary Session HANNA BLOOMFIELD RUBINS From Clinical Trial to Clinical Practice: Generalizing from Participant to Patient C. E. DAVIS Generalizing from Clinical Trials KENT R. BAILEY Generalizing the Results of Randomized Clinical Trials CHARLES D. COWAN AND JANET WITTES Intercept Studies, Clinical Trials, and Cluster Experiments: To Whom Can We Extrapolate? CHRISTY CHUANG-STEIN A New Proposal for Benefit-Less-Risk Analysis in Clinical Trials BONNIE P. GILLIS, ARLENE W. CAGGIULA, FRAN L. JONES, EMIL MAURER, REBECCA M. MEEHAN, MONICA E. YAMAMOTO, AND THE MODIFICATION OF DIET IN RENAL DISEASE STUDY Features of the Nutrient Database and Analysis System for the Modification in Renal Disease Study JEANNETTE Y. LEE, ALBERT OBERMAN, GERALD F. FLETCHER, JAMES M. RACZYNSKI, BARBARA J. FLETCHER, NAVIN C. NANDA, AND BETSY E. JENSEN Design of the Training Levels Comparison Trial IAN GORDON AND RAY WATSON Letter to the Editor A Note on Sample Size Determination of Small Probabilities Volume 15, Number 2, 1994 ROBERT J. CONNOR AND PHILIP C. PROROK Issues in Mortality Analysis of Randomized Controlled Trials of Cancer Screening JOHN E. OVERALL AND SUZANNE R. DOYLE Estimating Sample Sizes for Repeated Measurement Designs T. TIMOTHY CHEN AND RICHARD M. SIMON Extension of One-Sided Test to Multiple Treatment Trials THOMAS W. O’GORMAN, ROBERT F. WOOLSON, AND MICHAEL P. JONES A Comparison of Two Methods of Estimating a Common Risk Difference in a Stratified Analysis of a Multicenter Clinical Trial WILLIAM M. VOLLMER, MOLLY L. OSBORNE, STEPHANIE HERTERT, AND SONIA BUIST Recruiting Hard-to-Reach Subjects: Is It Worth the Effort? Volume 15, Number 3, 1994 HUGO W. MOSER Suspended Judgement Reactions to the Motion Picture “Lorenzo’s Oil” ALISON J. KIRBY, NOYA GALAI, AND ALVARO MUNOZ Sample Size Estimation Using Repeated Measurements on Biomarkers as Outcomes NANCY R. COOK, AND BERNARD A. ROSNER An Optimal Rule for Screening Subjects for Clinical Trials in the Presence of Within-Person Variability RICHARD J. COOK Interim Monitoring of Bivariate Responses Using Repeated Confidence Intervals ETTORE AMBROSIONI, CLAUDIO BORGHI, AND BRUNO MAGNANTI, ON BEHALF OF THE SMILE STUDY INVESTIGATORS Survival of Myocardial Infarction Long-Term Evaluation (SMILE) Study: Rationale, Design, Organization, and Outcome Definitions ANDREW R. WILLAN Power Function Arguments in Support of an Alternative Approach for Analyzing Management Trials ELIZABETH KIMBROUGH PRADHAN, JOANNE KATZ, STEVEN C. LeCLERQ, AND KEITH P. WEST Jr. Data Management for Large Community Trials in Nepal Volume 15, Number 4, 1994 CURTIS L. MEINERT Editorial Farewell Swan Song Reviewers of Controlled Clinical Trials Past Editorial Board Members ROGER P. GREENBERG AND SEYMOUR FISHER Suspended Judgment Seeing Through the Double-Masked Design: A Commentary GEORGE WILLS COMSTOCK Field Trials of Tuberculosis Vaccines: How Could We Have Done Them Better? SHANDE CHEN, SENG-JAW SOONG, AND RICHARD H. WHEELER An Efficient Multiple-Stage Procedure for Phase II Clinical Trials that Have High Response Rate Objectives MILENA J. HENZLOVA, GLENDA H. BLACKBURN, EDWIN J. BRADLEY, AND WILLIAM J. ROGERS FOR THE SOLVD CLOSE-OUT WORKING GROUP Patient Perception of a Long-Term Clinical Trial: Experience Using a Close-out Questionnaire in the Studies of Left Ventricular Dysfunction (SOLVD) Trial DIANE H. WILLIAMS AND C. E. DAVIS Reporting of Assignment Methods in Clinical Trials THE AGIS INVESTIGATORS The Advanced Glaucoma Intervention Study (AGIS): 1. Study Design and Methods and Baseline Characteristics of Study Patients Errata Announcement Queries Announcement (16th Annual Meeting) Volume 15, Number 5, 1994 DENISE HOWEL, AND RAJ BHOPAL Suspended Judgment Assessing Cause and Effect from Trials: A Cautionary Note WILLIAM O. WILLIFORD, WILLIAM F. KROL, STUART JON SPECHLER, AND THE VA COOPERATIVE STUDY GROUP ON GASTROESOPHAGEAL REFLUX DISEASE Development for and the Results of the Use of a Gastroesophageal Reflux Disease Activity Index as an Outcome Variable in a Clinical Trial KEITH ABRAMS, DEBORAH ASHBY, AND DOUG ERRINGTON Simple Bayesian Analysis in Clinical Trials: A Tutorial DONALD A. BERRY, MARK C. WOLFF, AND DAVID SACK Decision Making during a Phase III Randomized Controlled Trial CESAR G. VICTORA, ANA LANGER, FERNANDO BARROS, JOSE BELIZAN, UBALDO FARNOT, JOSE VILLAR, AND THE LATIN AMERICAN NETWORK FOR PERINATAL AND REPRODUCTIVE RESEARCH (LANPER) The Latin American Multicenter Trial on Psychosocial Support during Pregnancy: Methodology and Baseline Comparability GREG A GRANDITS, PHILIP R. LIEBSON, SINDA DIANZUMBA, AND RONALD J. PRINEAS Echocardiography in Multicenter Clinical Trials: Experience from the Treatment of Mild Hypertension Study MICHAEL BORENSTEIN The Case for Confidence Intervals in Controlled Clinical Trials Announcement Volume 15, Number 6, 1994 ANN LENNARSON GREER Scientific Knowledge and Social Consensus MARIA MORI BROOKS, LARRY GORKIN, ELEANOR B. SCHRON, INGELA WIKLUND, JEANNE CAMPION and ROBERT B. LEDINGHAM, for the CAST Investigators Moricizine and Quality of Life in the Cardiac Arrhythmia Suppression Trial Il (CAST II) TED A. GOOLEY, PAUL J. MARTIN, LLOYD D. FISHER, and MARY PETTINGER Simulation as a Design Tool for Phase I/II Clinical Trials: An Example from Bone Marrow Transplantation PETER F. THALL and RICHARD SIMON A Bayesian Approach to Establishing Sample Size and Monitoring Criteria for Phase II Clinical Trials DELLA GIBSON, ANGELA J. HARVEY, VINCENT EVERETT, and MAHESH K.B. PARMAR, on behalf of the CHART Steering Committee Is Double Data Entry Necessary? The CHART Trials ANNY H. XIANG, HARLAND N. SATHER and STANLEY P. AZEN Power Considerations for Testing an Interaction in a 2 x k Factorial Design with a Failure Time Outcome THE OSTR COLLABORATIVE GROUP The Ottawa Stroke Trials Registry Collaborative Group and the Development of the Ottawa Stroke Trials Registry (OSTR) ADELE GREEN, DIANA BATTISTUTTA, VERONICA HART, DAVID LESLIE, GEOFFREY MARKS, GAIL WILLIAMS, PHILIP GAFFNEY, PETER PARSONS, LAWRENCE HIRST, CHRISTINE FROST, ELIZABETH ORRELL, KATHRYN DURHAM, CAROLYN LANG, and the Nambour Prevention Study Group The Nambour Skin Cancer and Actinic Eye Disease Prevention Trial: Design and Baseline Characteristics of Participants ARGYE HILLIS Letter to the Editor Announcement Volume 15 Author Index Volume 15 Subject Index Volume Contents $