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Contemporary management of tooth replacement in the traumatized dentition. PDF

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DentalTraumatology2012;doi:10.1111/j.1600-9657.2012.01122.x Contemporary management of tooth replacement in the traumatized dentition REVIEW ARTICLE AwsAlani1,RupertAustin2, Abstract – Dentaltraumacanresultintoothlossdespitebesteffortsatretaining SerpilDjemal3 and maintaining compromised teeth (Dent Traumatol, 24, 2008, 379). Upper 1DepartmentofRestorativeDentistry,Newcastle anteriorteetharemorelikelytosufferfromtrauma,andtheirlosscanresultin DentalHospital,Newcastle;2Departmentof significant aesthetic and functional problems that can be difficult to manage Prosthodontics,Guy’sHospital,King’sCollege (EndodDentTraumatol,9,1993,61;IntDentJ59,2009,127).Indeed,teethof LondonDentalInstitute,London;3Departmentof poor prognosis may not only present with compromised structure but trauma RestorativeDentistryandTraumatology,Kings mayalsoresultindamagetothesupporttissues.Injurytotheperiodontiumand CollegeHospital,London,UK alveoluscanhaverepercussionsonsubsequentrestorativeprocedures(Fig.19). Where teeth are identified as having a hopeless prognosis either soon after the Keywords: diagnosis;permanenttooth; incident or at delayed presentation; planning for eventual tooth loss and prognosis;toothinjury;treatment replacement can begin at the early stages. With advances in both adhesive and osseointegration technologies, there are now a variety of options for the Correspondenceto:SerpilDjemal, DepartmentofRestorativeDentistryand restorationofedentatespacessubsequenttodentaltrauma.Thisreviewaimsto Traumatology,King’sCollegeHospital, identifykeychallengesintheprovisionoftoothreplacementinthetraumatized CaldecotRoad,LondonSE59RT,UK dentition and outline contemporary methods in treatment delivery. Tel.:02032995282 Fax:02032995678 e-mail:[email protected] Re-useofthisarticleispermittedin accordancewiththeTermsandConditions setoutathttp://wileyonlinelibrary.com/ onlineopen#OnlineOpen_Terms Accepted7January,2012 adulthood (12). The orthodontic-restorative interface Treatmentconsiderationsandthecontinuumofcare mayresultintreatmentoptionsthatdonotrequirefrank Dental trauma can present with severe injuries on prosthetictoothreplacement.Techniquesinorthodontic multiple teeth that were otherwise unrestored with no space closure and restorative augmentation with com- history of intervention up to that point. Indeed, when posite may provide acceptable and serviceable results teeth present with multiple concomitant injuries, the without the need for tooth tissue removal (Fig. 1) (13). relative prognosis of individual units may be difficult to Where tooth positions and stages of root development ascertain(4–6).Assuch,long-termplanningmaybebest are favourable autotransplantation of premolar, units carried out after the acute healing phase is complete. In have shown excellent long-term results (Fig. 2) (14). complex cases such as those of polytrauma, multidisci- Once post-trauma stabilization has been achieved, an plinary team planning may be sought as treatment objective assessment of the dentition can commence. options may depend onissues that the primary clinician Wherenon-vitalteethhavequestionablerestorabilitybut may not be fully sensitive to. Phased treatment moving are amenable to endodontic treatment, the primary aim from one discipline to another is a regular occurrence of preventing the development of an apical lesion and where orthodontic treatment is required or where surgi- postponingextractioncanbeconsideredanastutewayof cal intervention is envisaged (7, 8). These cases may be preserving the alveolar form (15, 16). Maintenance of best planned and reviewed in joint team meetings with teeth in this way can aide implant provision especially agreed strategies for future treatment (9, 10). In the where extraction and immediate placement is envisaged developingdentition, theoptionofimplants maynot be once growth is complete. available until growth is completed (11). In these cases, Contemporaryrestorationoftheedentatespaceinthe an orthodontic opinion may be sought early in the traumatized dentition should ideally be independent of process to assess future development and spacing. abutment teeth or minimally invasive without compro- Indeed, as alveolar dimensions and gingival maturity misingmassandqualityoftoothstructure.Conventional are likely to change through adolescence, treatment bridgework can result in loss of vitality of abutment planning should focus on the definitive option once teeth, whereas removable partial dentures may result in growthhasceased.Thissituationrequiressomeforesight significant plaque accumulation and also lack social as longitudinal planning can optimize outcomes into acceptability (17–19). The utilization of minimally inva- (cid:2)2012JohnWiley&SonsA/S 183 184 Alaniet al. (a) (b) Fig.1. (a) 21-year-old patient who pre- viouslylost21becauseoftrauma.Ortho- dontic space optimization was instigated followed by composite augmentation of the22tomimica21(b). (a) (b) matology especially where immature pulp tissue may be present. This concept is more relevant in the developing dentition where changes in tooth position, alveolar growth and tooth prognosis are still to be realized (21) (Fig. 3). Where teeth have erupted to a level that provides adequate surface area for bonding resin bridges can be delivered. Indeed, their provision can be considered a definitive option where there is inad- equate bone volume and quality and where favourable abutment teeth are present (21) (Fig. 4). This option may be more carefully considered by the patient where the need for numerous surgical episodes is required for an osseointegrated restoration, in comparison, the resin-bonded bridge can be delivered sooner with minimal morbidity. Preparationorconsolidation? The median survival rate for resin bridges has been shown to be just under 10 years with an 87.7% survival rate of bridges and splints at 5 years (22, 23). Features thathavebeenshowntoimprovesurvivalincludesurface area covered by the retainer, operator experience and Fig.2. (a)Longconeperiapicalof11followingtraumawhich design (24). The extent to which the abutment can be resulted in mid-root fracture of the 11. (b) The tooth was extracted and an autotransplanted premolar was used to preparedvaries(20)andsuccesscanbeachievedwithout replace. Composite augmentation and root canal treatment preparation; although this needs to be balanced against was completed on a subsequent visit. Case courtesy of evidence that has suggested improved longevity when the Department of Paediatric Dentistry, Newcastle Dental retentive featuressuchas restseats andguideplanesare Hospital. incorporated (24). Newer techniques in optimizing the enamelsurfaceincludetheuseofintraoralsandblasting sive techniques may be clinically successful without the prior to etching although this has not been evaluated need for further intervention. fully (25). This technique may be particularly useful where the tooth surface is extrinsically stained or where residual resin remains from previous bonding attempts. Traumaandtheresin-retainedtechnique Indeed, the use of bioactive-glass air abrasion that can The original work by Rochette some 40 years ago on selectively remove resin as opposed to enamel has also a technique for bonding metal splints to periodon- been developed (26) (Fig. 5). Where gingival tissues tally involved teeth has since undergone significant encroachonthepalatalaspectofthepotentialabutment, developments and improvements in addition to new thiscanlimitthesurfaceareaforbondingandtheheight concepts and indications (20). The ability to provide a of the connector (Fig. 6). These problems can be prosthetic replacement without biologically harmful addressed utilizing electrosurgery to simultaneously and irreversible preparations has applications in trau- augment the prospective pontic site to improve emer- (a) (b) Fig.3. (a)14-year-oldpatientpresentingwithdecoronationofthe21andsubluxationof11.Bothteethwererootcanaltreatedand asymptomaticatreview.(b)Resin-bondedbridgeworkcantileveredfromthe22intothe21space.Theguardedprognosisofthe11 precludeditasanabutment.Oncegrowthiscompleted,thedefinitiverestorationofthe21areawithanimplantwillbeconsidered. (cid:2)2012JohnWiley&SonsA/S Management of toothreplacement in thetraumatized dentition 185 Fig.4. Resin-bonded bridge cantilevered from the 13 into the 12space.Initialinvestigationsrevealedtheneedforgraftingin the 12 site for an implant. The patient was not keen on this option,andadefinitiveresinbondedbridgewasfitted. Fig.5. IntraoralsandblastingpriortoRBBcementationunder gencewhilstalsoexposinggreaterenameltissuepalatally rubberdamisolation. (27). The maintenance of soft tissue postsurgery can be achieved by way of relining a removable prosthesis (Fig. 6c). the cement lute to the retainer wing being stronger than Where there is a lack of interocclusal space between that to metal because of greater linearity between the potential resin-retained abutments and opposing tooth materials. The dentist has the choice of fabricating the units, the cementation of restorations at an increased prosthesis directly (if for example an avulsed tooth is occlusal vertical dimension to create space has been available to be modified) or indirectly (Fig. 8). One described (28). This technique can prevent the need for consideration is the need for greater occlusal clearance tooth preparation and where there is limited prosthetic requiredfortheretainers,andcantileverdesignsmaynot envelopeforfuturerestorations,spacecanbecreatedfor be achievable because of the lack of rigidity. definitiveplanning(Fig. 7).Axialtoothmovementsvary Apracticaladvantageofresin-bondedbridgesistheir between individuals; younger patients have a greater retrievability, especially where a multiphase treatment scope for a combination of intrusion and eruption, plan is envisaged (Fig. 9). Initial cementation post- whereas in older patients, the movements are predom- trauma may provide an interim measure until growth is inantly intrusion (29). completedorthedentitionfullystabilized.Resin-bonded bridges lend themselves to this ethos as removal is relatively straightforward by ‘tapping off’ the bridge Newmodalities when needed. The use of glass ionomer cement as Technologicaldevelopmentsinadhesivetechnologyhave opposed to resin composite has also been recommended resulted in the ability to utilize the crowns of avulsed where removal is envisaged at a later date. teeth as pontics in an immediate manner (Fig. 8) (30). Further to this, the development of fibre-reinforced Utilizationinmulti-phasedtreatment resin-bonded bridges has presented clinicians with greater choice when considering minimally invasive Banerji and colleagues examined the use of RBBs as an optionsfortoothreplacement(31).Thesematerialshave interim restoration during implant treatment (33). The been described as resin-based restorations containing study examined two phases in the use of the Rochette fibres aimed at enhancing their physical properties (32). bridge, the first after immediate cementation following As the framework is tooth coloured, aesthetic problems extractionandthesecondatthetimeofimplantsurgery relatingtoshowthroughofabutmentscanbeminimized and recementation. In the first phase, 16% of bridges (32). There is potential for development of the bond of requiredrecementationincomparisonwith27.5%andin (a) (b) Fig.6. (a) Previous trauma resulted in the lossof the11. Notethe excess tissue in the 11 site making potential pontic dimensions difficult to match with adja- centgingivalmargins.(b)Electrosurgery to create ideal pontic space for resin- (c) (d) bonded bridgework in addition to max- imizing enamel surface area palatally on 21.(c)Tomaintainthesofttissuedimen- sions,theretainerwasrelinedandfitted. (d) The definitive resin-bonded bridge cemented from the 21 cantilevered into the11space. (cid:2)2012JohnWiley&SonsA/S 186 Alaniet al. (a) (b) (c) Fig.7. (a)15-year-oldpatientwhosufferedacombinationofavulsions,alveolarandrootfractures.Theseweremanagedsurgically andprimaryclosurewasachieved.Atanearlystage,thelackofinterocclusalspaceforsubsequentrestorationoftheedentatespace wasapparent.(b)TocreateinterocclusalspaceutilizingtheDahlapproach,aresin-bondedbridgewascementedfromthe13tothe 22atanincreasedocclusalverticaldimension.(c)After6monthsofwearposteriorcontactsre-establishedandadequateinterocclusal spacewascreatedfortheplacementofimplantstodefinitivelyrestorethespace. Fig.8. Immediate resin-bonded bridgework for 21 space uti- lizingcarbonfibrematerial. Fig.9. Rochettestylebridgeutilizedinamultiphasetreatment plan. This patient was fitted with the resin-bonded bridge immediately after extraction. The bridge was modified to the second phase, 7.2% of bridges required recementa- accommodateahealingabutmentandrecementedafterimplant placement. tion in both phases (33). Interestingly, there was marginal difference in probability of survival between thetwophasesover200 dayswithphaseonebeing80% resin-retained bridgework is limited. Indeed, if occlusal andphasetwo78%.Thisstudyprovidessomescopefor factors and abutment teeth are unfavourable, the clini- RBBuseinthelongitudinaltreatmentofthetraumatized cianmustconsiderdentalimplantsasanalternativefixed dentition (33). treatment option. Limitationsofthetechnique Osseointegrationinthetraumatizeddentition Resin-retained bridges have disadvantages that may Managingtheaftermathoftrauma result in the consideration of alternative options. The reported survival rates may be less than alternative, Planning for implants in the trauma patient can be albeit more invasive options, such as conventional challenging as well as clinically difficult particularly bridges or implants (23). Indeed, the degree of patient when the extent of trauma is directly related to the satisfactionwithresin-bondedbridgesappearstobehigh feasibility oftreatment(Fig. 10).Postextractionchanges anddoesnotseemtobeinfluencedbytheoccurrenceof can result in buccal bone loss making implant provision failureorthepossibilityofrecementation(34).Provision more difficult (36). Attempts at maintaining hard and of RBBs retained by thin anterior teeth may result in soft tissue topography have included atraumatic extrac- metal show through which may not be acceptable to tion techniques in combination with adjunctive tissue some patients. This can be minimized by use of an regeneration (37). In comparison, the pathophysiology opaque cement (20).Try-in of the restoration is difficult of dental trauma with the possibility of a superimposed due to absence of retention without cementation. This endodontic infection fuelling the resorptive process can be remedied using calcium hydroxide-based lining results in a more aggressive and rapid loss of bone and materialstotemporarilyfixatethebridgeinsitutoassess soft tissue contour. Ankylosis and progressive bone or aesthetics (35). Occlusal control may be difficult to root resorption can further complicate treatment. As a achieve because of the encroachment on previous ante- result, techniques of elective decoronation have been rior guidance pathways, in cases of poly-trauma, described with the aim of preventing infraocclusion and potential abutment teeth may be compromised preclud- allowing alveolar development to continue (38–40) ing them as suitable abutments. In cases where multiple (Fig. 11).Wherehorizontalfracturespresent,theextrac- adjacent teeth are lost, the scope for the provision of tion of both fragments or simply the most coronal (cid:2)2012JohnWiley&SonsA/S Management of toothreplacement in thetraumatized dentition 187 portion needs to be considered (Fig. 12). Attempts at (a) retrieval of an apical fragment may result in the loss of further bone because of restricted access. In contrast, retentionofthefragmentanditsremovalattheimplant placement stage although desirable may be difficult to achieve. This remains an area where the clinician’s best judgment in retaining as much bone as possible for implantplacementneedstobebalancedagainsttheneed for fragment removal.Recent innovationsinatraumatic exodontiahaveincludedtheuseofimplantdrillstothin root walls prior to implant placement and the use of special elevators and modified piezo tips for dissecting theperiodontalligament(41–43)(Fig. 13).Thedifficulty in dealing with such cases may require input from surgical colleagues in the execution of adjunctive proce- dures for subsequent implant placement. Optimizationoftheedentatesite Where multiple teeth are lost or alveolar bone has resorbedfollowingtrauma,theneedforadjunctivebone grafting prior to provision of implants may need to be considered. Indeed, the clinical appearance may not reveal the true extent of the bone deficit because of hypertrophy of the mucosa (Fig. 10). The assessment of the edentate site can be evaluated using a variety of techniquessuchasclinicalridgemappingorconebeam– computerizedtomography(44).Wherethereisalackof bone width in the presence of adequate vertical height, onlaygraftingcanbeutilized(Fig. 14).Thiscanestablish bucco-palatalbonewidthbutalsoimprovesthescopeto placetheimplantintheappropriateaxialandmesio-distal (b) position.Theoptionsfordonorsitesincludetheascend- ing ramus, the anterior mandible or an extra-oral site. Adjunctive procedures are not without complications; partialortotalblockgraftfailurehasbeendocumentedat 7% and 8%, respectively (45). In contrast, soft tissue complications were more common ranging from mem- brane exposure (30%), incision line opening (30%), perforation of the mucosa over the graft site (14%) and infectionofthegraftsite(13%)(45). Forcible orthodontic eruption of an otherwise unre- storablelateralincisorforthepurposesofalveolarbone development has been described (46) (Fig. 15). In cases Fig.10. (a) This patient suffered trauma to the 21 which was where vertical augmentation is required, distraction subsequentlytreatedwithorthogradeendodonticsfollowedby osteogenesis can be considered either for a single or apical surgery. Because of persistent infection, the tooth was multiple unit sites. The movement of arch segments by extracted. (b) CBCT examination revealed an obvious bony way of distraction osteogenesis has been described for defect which was not amenable to implant placement. The feasibilityofbonegraftplacementwasalsodifficulttopredict implantsiteoptimization(47).Distractiondevicesplaced becauseofthelackofbonepresenttoreceivedonortissue. after osteotomy preparation can be transalveolar or extra-alveolar and can require surgical fixation. A latency period of 1 week prior to commencing the loss of two adjacent teeth is present. Where bone distraction at the rate of 0.5–1 mm a day has been volume is adequate but soft tissues are deficient, the recommended although this will depend on the individ- clinician may consider the use of graft procedures to ual case and the magnitude of distraction required (48). optimize soft tissue coverage. Alternatively, the patient maybekeenonanimplant-basedrestorationwithoutthe need for adjunctive grafting. The option of gingivally Theimportanceofsupporttissueprofile tonedceramicasanalternativetoverticalaugmentation Where adequate alveolar mass and gingival biotype is andsofttissuegraftinghasbeenrecentlyhighlighted(49) present, the provision of implant restorations anteriorly (Fig. 16). can be predictable providing adequate aesthetics and Thegingivalcomponent ofa restoration isimportant function.Suchprovisionmaybemorecomplicatedwhen especially where osseointegration is planned. The aes- (cid:2)2012JohnWiley&SonsA/S 188 Alaniet al. thetics of the gingiva associated with a restoration has (a) (b) been shown to be a factor in the success of the restoration (50). Patients with a thicker biotype have shownmorefavourablelong-termresultsthanthosewith thinnersofttissues(51).Inarecentstudyof513patients presenting with orofacial trauma, 29.2% had signs of eithergingivalororalmucosainjuries(52).Bothbiotype and previous trauma injuries may affect the degree to which these tissues can be manipulated. Techniques in the creation of a gradual natural emergence profile of implant restorations have been described (53, 54) (Fig. 14). These techniques aim to manipulate the peri- implant tissues to create a more natural emergence. Foresight in the management of soft tissues in acute traumabyoptimizinghealingmayimprovethescopefor tissue manipulation for future restorations. Fig.11. (a)Radiographicexaminationofthe11and12showed external and internal inflammatory resorption and external Timingofimplantplacement replacement resorption. (b) The 11 and 12 were accessed and guttapercharemovedandweresubsequentlydecoronatedwith Thevarioustimingsofimplantplacementpostextraction surgicalclosure. haverecentlybeeninvestigated(55).Asystematicreview comparing the outcomes of immediate, immediate delayedandordelayedimplantssuggestedthatimmedi- (a) (b) ateandimmediatedelayedplacementcamewithahigher chance of postoperative complications although imme- diate placement may present with better aesthetic out- comes (55) (Fig. 17). Despite these conclusions, the authorsfeltthereisaneedforbetterqualityofevidence as the current literature is sparse, underpowered and carriedahighriskofbias(55).Morespecificstudieshave examined the outcomes of implants placed in extraction sites of teeth with periapical lesions (56–58). One systematic review concluded that the immediate approach may require thorough debridement of the extraction socket, prophylactic antibiotics, tissue regen- eration and in some cases result in impaired bone to implant contact (58). Other controlled studies have shown favourable results with limited complications andsurvivalupto3 years(56,57).Aslong-termoutcome studies are lacking, the predictability and longevity of placingimplantsimmediatelyintoextractedsitesisstillto Fig.12. (a)Delayedpresentationofamid-rootfractureanda be realized. Where teeth are avulsed in an acute trauma periapicallesion.(b)The21wasreplacedwithanimplant. situation, the clinician may be faced with the option of placingan implantinto arecentlytraumatized site. This decisioncanbedifficultastheuncertaintiesofprognosis of adjacent teeth and the status of bone in the avulsion site itself can be hard to judge. Immediate implant placement reduces the number of surgical episodes and treatment time. The procedure may be technique sensi- tive,theremaybealackofkeratinizedtissueavailablefor flapadaptation,andthesitemorphologymaycomplicate optimal placement. In contrast, the delayed immediate approach at 4–8 weeks which will have increased kera- tinized soft tissue available in addition to assessment of any developing pathologies. Unfortunately, the healing sitemayhavealreadyundergonesignificantresorptionby thetimetheimplantisplaced. Theimplantprovisionpathwayintraumapatientshas been examined in a retrospective study (59) where implants were placed in 42 sites between 6 months to 11 years post-trauma. In 17% of cases, there was a Fig.13. Piezo powered bone and periodontal ligament dissec- deficiency of bone that required adjunctive procedures. tion. (cid:2)2012JohnWiley&SonsA/S Management of toothreplacement in thetraumatized dentition 189 (a) (c) (c1) (b) (d) Fig.14. (a) Onlay graft in the 22 site where previous avulsion had resulted in deficient alveolar profile for implant placement. (b)Interim implantrestoration 22.Notethelackofemergence. (c)Flowablecompositemodificationoftheinterimrestoration to creategradualemergenceandform.(d)Thedefinitiverestorationwithdevelopedemergenceform. Fig.16. Traumatic loss of 11 and 12 resulted in a marked Fig.15. Patient undergoing orthodontic extrusion for the verticalandhorizontaldefect.Thepatientpreferredtheuseof purpose of implant site development in the 11 site. The 11 gingivally toned ceramic as opposed to bone and soft tissue hasbeenextrudedutilizingaminiimplantplacedapically.Case grafting prior to implant placement. Case courtesy of Amre courtesyofBillIp,NewcastleDentalHospital. Maglad,NewcastleDentalHospital. Four of the 42 implants exhibited postsurgical compli- speculate as to whether immediate implantation follow- cations, whereas five exhibited complications after ingtoothlossmayhavepreventedtheneedforgrafting. cementation of the crown. One significant finding was This view may be strengthened by a more recent that patients who had long-standing tooth loss required retrospective study of 53 trauma patients provided with grafting.Inadditiontothis,allpatientswhohadlosttwo implants. Eighty-one per cent required bone augmenta- or more adjacent teeth also required grafting. One may tionthatincludedonlaygraftsorguidedboneregenera- (cid:2)2012JohnWiley&SonsA/S 190 Alaniet al. (a) (b) Fig.17. (a)Decoronationof43asaresultoftrauma.Becauseofthelimitedsupragingivaltissueavailableforrestoration,thetooth wasdeemedashavingapoorprognosis.(b)Definitiverestorationafterextractionandimmediateimplantplacement. (a) (b) Fig.18. (a)Thispatientsufferednumerousinjuriessubsequenttoaroadtrafficaccidentapproximately25yearsago.Shelostthe majorityofhermandibularteethinadditiontotheneedforgraftingandfixation.Oncestabilized,shewasprovidedwithanimplant retained prosthesis. (b) Radiograph 20years after initial provision. During this period, the patient presented with a variety of maintenance requirements that included clip fractures, abutment screw loosening, overdenture replacement and peri-implant mucositis. ing care is likely to be of great significance in future as our patients are living for longer (61). Biologicalcomplicationssuchasperi-implantitishave been reported to be as high as 56% (62). Mechanical complications such as abutment screw fracture or loosening also need consideration. Mechanical compli- cationsmaybemorelikelyinapatientwhoissusceptible to trauma. Stuebinger and colleagues reported the bending of abutment screws in a patient who sustained traumatohisimplant restorations(63).Allen andAllen Fig.19. Poly-trauma presenting with decoronation of the 21, (64) reported the fracturing of inter-implant bone luxation of the 11, fracture of the implant crown 12, gingival subsequent to a blow to the face which also resulted in lacerationsandasinusassociatedwiththe11. abutment screw bending. Flanagan (65) reported the fracturing of implant crowns when soft tissue injuries were sustained. It would seem sensible to consider the tion and 47% underwent immediate placement and in likelihood of repeat trauma and its repercussions on some cases with immediate loading (60). The authors tooth replacement and subsequent maintenance when found a 45% complication rate, although complications managing this group of patients. were significantly less in those cases with no previous historyofperiapicalpathology.Theresultsofthisstudy maystrengthenthecaseforremedialrootcanaltreatment Conclusion todecreasethepresenceofinflammationandpotentially The provision of tooth replacement in the traumatized increaseboneforapicalengagementoftheimplant. dentitionhasspecificchallengesthatmaynotbepresentin patientswhohavesufferedplaque-relatedtoothloss.This Long-termmaintenanceofimplantsinthetraumapatient can make the treatment planning process more difficult Asthemajorityoftraumaticinjuriesoccurintheyoung requiringadjunctiveprocedurestoaidthedefinitiveresult. or adolescent patient, the restorative dentist needs to consider the longevity and serviceability of the restora- References tion(Figs 18and19).Indeed,ifdefinitivetoothreplace- menttherapyisprovidedsoonaftergrowthiscompleted, 1. 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