CONTEMPORARY CONCEPTS IN CARDIOLOGY Pathophysiology and Clinical Management Developments in Cardiovaseular Medieine 198. Antoine Lafont, Erie TopoI (eds.): Arterial Remodeling: A Critical Factor in Restenosis. 1997 ISBN 0-7923-8008-8 199. Micheie Mercuri, David D. MePherson, Hisham Bassiouny, Seymour Glagov (eds.):Non-lnvasive Imaging ofA therosclerosis ISBN 0-7923-8036-3 200. Walmor C. DeMello, Michiel 1. Ianse(eds.): Heart Cell Communication in Health and Disease ISBN 0-7923-8052-5 201. P.E. Vardas (ed.): Cardiac Arrhythmias Pacing and Electrophysiology. The Expert View. 1998 ISBN 0-7923-4908-3 202. E.E. van der Wall, P.K. Blanksma, M.G. Niemeyer, W. Vaalburg and H.J.G.M. Crijns (eds.) Advanced Imaging in Coronary Artery Disease, PET, SPECT, MRI, 1 VUS, EBCT. 1998 ISBN 0-7923-5083-9 203. R.L. Wilensky (ed.) Unstable Coronary Artery Syndromes, Pathophysiology, Diagnosis and Treatment. 1998. ISBN 0-7923-8201-3 204. 1.H.C. Reiber, E.E. van der Wall (eds.): What's New in Cardiovascular Imaging? 1998 ISBN 0-7923-5121-5 205. Iuan Carlos Kaski, David W. Holt (eds.): Myocardial Damage Early Detection by Novel Biochemical Markers. 1998. ISBN 0-7923-5140-1 207. Gary F. Baxter, Derek M. Yellon, Delayed Preconditioning and Adaptive Cardioprotection. 1998. ISBN 0-7923-5259-9 208. Bemard Swynghedauw, Molecular Cardiology for the Cardiologist, Second Edition 1998. ISBN 0-7923-8323-0 209. Geoffrey Bumstock, Iames G.Dobson, Ir., Bruce T. Liang, Ioe1 Linden (eds): Cardiovascular Biology of Purines. 1998. ISBN: 0-7923-8334-6 210. Brian D. Hoit, Richard A. Walsh (eds): Cardiovascular Physiology in the Genetically Engineered Mouse. 1998. ISBN: 0-7923-8356-7 211. Peter Whittaker, George S. Abela (eds.): Direct Myocardial Revascularization: History, Methodology, Technology 1998. ISBN: 0-7923-8398-2 212. C.A. Nienaber, R. Fattori (eds.): Diagnosis and Treatment of Aortic Diseases. 1999. ISBN: 0-7923-5517-2 213. Juan Carlos Kaski (ed.): Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management. 1999. ISBN: 0-7923-8421-0 214. P.A. Doevendans, R.S. Reneman and M. Van Bilsen (eds): Cardiovascular Specijic Gene Expression. 1999 ISBN:0-7923-5633-0 215. G. Pons-Llad6, F. Carreras, X. Borras, Subirana and L.I. Iimenez-Borreguero (eds.): Atlas of Practical Cardiac Applications of MRI. 1999 ISBN: 0-7923-5636-5 216. L.W. Klein, 1.E. Calvin, Resource Utilization in Cardiac Disease. 1999. ISBN :0-7923-8509-8 217. R. Gorlin, G. Dangas, P. K. Toutouzas, M.M Konstadoulakis, Contemporary Concepts in Cardiology, Pathophysiology and Clinical Management. 1999 ISBN:0-7923-8514-4 previous volumes are still available SPRINGER SCIENCE+BUSINESS MEDIA, LLC CONTEMPORARY CONCEPTS IN CARDIOLOGY Pathophysiology and Clinical Management Richard Gorlin Pavlos K. Toutouzas George Dangas M.M. Konstadoulakis Mount Sinai School National University of Athens of Medicine, New York School of Medicine Foreword by J. WiIIis Hurst .... " Springer Science+Business Media, LLC ~. " Library of Congress Cataloging-in-Publication Data A c.I.P. Catalogue record for this book is available from the Library of Congress. Themata sygchrones kardiologias. English. Contemporary concepts in cardiology: Pathophysiology and clinical management/[edited by] Richard Gorlin ... [et al.] foreword by J. Willis Hurst. P. Cm. --(Developments in cardiovascular medicine: 217) Includes index. ISBN 978-1-4613-7274-5 ISBN 978-1-4615-5007-5 (eBook) DOI 10.1007/978-1-4615-5007-5 1. Cardiovascular system--Diseases--Treatment. 1. Gorlin, Richard, 1926- . II. Title. III Series: Developments in cardiovascular medicine : v. 217. [DNLM: 1. Cardiovascular Diseases--diagnosis. 2. Cardiovascular Diseases--physiopathology. 3. Cardiovascular Diseases--therapy, WG 120 T383 1999]. RC671.T47 1999 616.1--dc21 DNLMlDLC 99-26059 for Library of Congress CIP Copyright © 1999 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 1999 Softcover reprint of the hardcover 1 st edition 1999 AlI rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photo copying, recording, or otherwise, without the prior written permission of the publisher, Springer Science+Business Media, LLC , Printed on acid-free paper. To our students and colleagues R.G., P.K.T To my parents and my associates G.D. To my parents M.M.K CONTEMPORARY CONCEPTS IN CARDIOLOGY Pathophysiology and Clinical Management Foreword ................................................................................... xiii J. Willis Hurst Preface ..................................................................................... xv George Dangas, Richard Gorlin Prologue ................................................................................... xvii Pavlos K. Toutouzas, Manoussos M. Konstadoulakis Section A CORONARY ARTERY DISEASE Chapter 1 PATHOGENESIS OF ATHEROSCLEROSIS ............................................ 3 Antonio Fernandez-Ortiz, Juan J Badimon, Valentin Fuster Chapter 2 SYNDROMES OF ACCELERATED ATHEROSCLEROSIS ................... 19 Beat Meyer, Una Badimon, James H. Chesebro Chapter 3 LIPOPROTEINS AND APOPROTEINS ................................................... 28 Elena Citkowitz, Peter Herbert Chapter 4 LIPID LOWERING THERAPY ................................................................. 69 Donald A. Smith Chapter 5 SILENT MYOCARDIAL ISCHEMIA ...................................................... 102 Brian Schafer, Thomas C. Andrews, Peter H. Stone viii Chapter 6 VASOSPASTIC ANGINA ....................................................................... 114 Attilio Maseri, Gaetano A. Lanza Chapter 7 THE ROLE OF NITRIC OXIDE IN CORONARY DISEASE ................. 125 Todd J. Anderson, Ian T. Meredith, Fran90is Charbonneau, Peter Ganz, Andrew P. Selwyn Chapter 8 THROMBOLYTIC AND ANTITHROMBOTIC THERAPIES FOR ACUTE CORONARY SYNDROMES ............................................ 142 Christopher P. Cannon, Joseph Loscalzo Chapter 9 DEVELOPMENT OF COLLATERAL CORONARY CIRCULATION ..... 176 Olga Hudlicka, Margaret Brown Section B HYPERTENSION Chapter 10 INSULIN RESISTANCE, AND HYPERTENSION ................................ 195 Fred Slogoff, Eric Wasserman, Robert A. Phillips Chapter 11 AMBULATORY BLOOD PRESSURE MONITORING ........................... 217 Peter A. Kringstein, Ethan D. Loeb, Robert A. Phillips Chapter 12 ANGIOTENSIN CONVERTING ENZYME INHIBITORS ....................... 228 Theodore D. Mountokalakis Chapter 13 DISTENSIBILITY OF THE GREAT VESSELS AND HYPERTENSION .......................................................................... 236 Christos Pitsavos, Christodoulos I. Stefanadis, Pavlos K. Toutouzas ix Section C CARDIOMYOPATHIES Chapter 14 PATHOPHYSIOLOGY AND MANAGEMENT OF HEART FAILURE .. 249 Daniel Levy, George Dangas, Richard Gorlin Chapter 15 HYPERTROPHIC CARDIOMYOPATHY ............................................... 267 David P. Dutka, Celia M. Oakley Chapter 16 DILATED CARDIOMYOPATHY ............................................................ 278 P. J. Keaning, William J. McKenna Chapter 17 AUTOIMMUNE CARDIAC DISEASES ................................................. 294 Manoussos M. Konstadoulakis, George D. Kymionis, Marina G. Toutouza, Emanuel Leandros Chapter 18 CARDIAC TRANSPLANTATION ........................................................... 302 Ronald S. Freudenberger, Alan Gass Section D CARDIAC GENETICS Chapter 19 DIFFERENTIAL GENE EXPRESSION IN MUSCLE ............................ 315 R. Sanders Williams Chapter 20 GENETIC ANALYSIS OF CARDIOVASCULAR DISEASE .................. 332 Ralph V. Shohet x Chapter 21 GENETICS OF HYPERTROPHIC CARDIOMYOPATHY ...................... 345 Calum MacRae Chapter 22 GENE THERAPY FOR CARDIOVASCULAR DISEASES .................... 355 David W. M. Muller Section E NONINVASIVE CARDIOLOGY Chapter 23 NUCLEAR IMAGING TECHNIQUES .................................................... 381 Diwakar Jain, Barry L. Zaret Chapter 24 ECHOCARDIOGRAPHY IN THE EVALUATION OF CORONARY ARTERY DISEASE .................................................... 397 Rebecca T. Hahn, Richard B. Devereux Chapter 25 TRANSESOPHAGEAL ECHOCARDIOGRAPHY .................................. 421 Alan S. Katz Chapter 26 DUPLEX VASCULAR ULTRASONOGRAPHY ...................................... 434 Aris Antoniou, Lampros Vlahos Section F INTERVENTIONAL CARDIOLOGY Chapter 27 TREATMENT OPTIONS FOR CORONARY REVASCULARIZATION ......................................................................... 449 Roxana Mehran, Martin B. Leon xi Chapter 28 CORONARY ATHERECTOMY .............................................................. 463 Samin K. Sharma, Annapoorna S. Kini Chapter 29 EXCIMER LASER ANGIOPLASTY ....................................................... 479 Henry S. Ting, Farris K. Timimi, John A. Bittl Chapter 30 NOVEL INTERVENTIONAL TECHNIQUES FOR ACUTE CORONARY SYNDROMES ............................................ 490 David R. Holmes, Jr., Robert S. Schwartz Chapter 31 INTRACORONARY ULTRASOUND ...................................................... 504 George Dangas, Paul G. Yock Chapter 32 RESTENOSIS ........................................................................................ 521 George Dangas, Roxana Mehran Chapter 33 BALLOON MISTRAL VALVULOPLASTY .............................................. 538 Christodoulos I. Stefanadis, Pavlos K. Toutouzas Section G ELECTROPHYSIOLOGY Chapter 34 PHARMACOLOGIC THERAPY OF ARRHYTHMIAS ........................... 559 John Kassotis, Roy Sauberman, James Coromilas Chapter 35 ABLATIVE THERAPY FOR ARRHYTHMIAS ........................................ 600 J. Anthony Gomes, Davendra Mehta