Concepts and Principles of Pharmacology: 100 Years of the Handbook of Experimental Pharmacology PDF
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Handbook of Experimental Pharmacology 260 James E. Barrett Clive P. Page Martin C. Michel Editors Concepts and Principles of Pharmacology 100 Years of the Handbook of Experimental Pharmacology Handbook of Experimental Pharmacology Volume 260 Editor-in-Chief JamesE.Barrett,Philadelphia EditorialBoard VeitFlockerzi,Homburg MichaelA.Frohman,StonyBrook PierangeloGeppetti,Florence FranzB.Hofmann,München MartinC.Michel,Mainz CliveP.Page,London WalterRosenthal,Jena KeWeiWang,Qingdao TheHandbookofExperimentalPharmacologyisoneofthemostauthoritativeand influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unri- valledreferencesource. HEPisindexedinPubMedandScopus. Moreinformationaboutthisseriesathttp://www.springer.com/series/164 (cid:129) (cid:129) James E. Barrett Clive P. Page Martin C. Michel Editors Concepts and Principles of Pharmacology 100 Years of the Handbook of Experimental Pharmacology Editors JamesE.Barrett CliveP.Page CenterforSubstanceAbuseResearch SacklerInstituteofPulmonaryPharmacology, LewisKatzSchoolofMedicineatTemple InstituteofPharmaceuticalScience University King’sCollegeLondon Philadelphia,PA,USA London,UK MartinC.Michel DepartmentofPharmacology JohannesGutenbergUniversity Mainz,Rheinland-Pfalz,Germany ISSN0171-2004 ISSN1865-0325 (electronic) HandbookofExperimentalPharmacology ISBN978-3-030-35361-2 ISBN978-3-030-35362-9 (eBook) https://doi.org/10.1007/978-3-030-35362-9 #SpringerNatureSwitzerlandAG2019 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthe materialisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation, broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformation storageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodology nowknownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. The publisher, the authors and the editors are safe to assume that the advice and information in this bookarebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsor theeditorsgiveawarranty,expressedorimplied,withrespecttothematerialcontainedhereinorforany errorsoromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregardtojurisdictional claimsinpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG. Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Preface This volume celebrating the 100th anniversary of the Handbook of Experimental Pharmacology acknowledges several significant milestones in the discipline of Pharmacology. Moreover, it is a testimony to the evolution of the scientific scope andbreadthandoftheimportantroletheHandbookhashadincapturingthemany advancesoverthis100-yearperiod.TheHandbookwasfoundedin1919byArthur Heffterasthe“HandbuchderExperimentellenPharmakologie.”AsofVolume50in 1978, the series was renamed to its current title. The first volume published in English was in 1937, titled “General Pharmacology” and the entire volume was written by Alfred Joseph Clark from the University of Edinburgh. The series has publishedmorethan250volumes,representingacontinuingtraditionandcommit- menttotheevolutionofpharmacologyasavibrantdisciplineingeneratinginnova- tive basic and clinical research that have facilitated the development of safe and effective therapeutics. While originally designed as a handbook, each chapter and theentirevolumesarenowavailableelectronicallyandprimarilyusedinthisway. ThecollectionofvolumesoftheHandbookofExperimentalPharmacologyover thepast100yearsreflectsthetremendousgrowthofthedisciplineofpharmacology and provides tangible stepping-stones to the many significant advances in the discovery and development of new drugs for a wide range of diseases. The Hand- book has consistently provided critical and comprehensive reviews of the most significant areas of pharmacological research, written by leading international authorities, and contributing significantly to the tremendous progress evidenced overthepast100years. The Handbook has captured and disseminated the dynamic nature of the disci- pline of pharmacology, celebrating and publishing new discoveries from basic understanding of mechanisms of drug action to the delivery of new, safe, and effective therapeutics. Writing in the Handbook over 50 years ago, the Nobel Laureate Sir Henry Dale, commented that “Heffter’s great Handbuch der ExperimentellenPharmakologiemayberegarded,perhaps,asgivingsomemeasure of the prodigious growth, during the past half-century, of those areas of scientific knowledge which can properly be regarded now as belonging to the domain of Pharmacology.Andtomakeitsfullcontributiontoexperimentalprogressonthese lines,pharmacologywouldnowhavetoworkinanincreasingintimacyofcoopera- tion, with the accelerating growth of relevant knowledge in physiology, v vi Preface biochemistry, pathology, and immunology, and, indeed, in any of the more funda- mental scientific disciplines.” That growth and the “intimacy” predicted by Dale havecontinuedaspharmacologyhasevolvedandembracedthoseinteractions.The imprint of the evolution of pharmacology is strongly reflected in the series, which includescontributionsfromover20NobelLaureates.Thesefundamentaladvances have generated newer and deeper insights into signaling pathways, elucidated our understanding of molecular mechanisms of drug action, while also witnessing remarkable advances in Quantitative Systems and Computational Pharmacology, as well as in enabling technologies such as Pharmacogenomics, Metabolomics, NaturalProducts,andDrugDeliverySystems,tonamejustafew. While it is difficult to cover all the developments in pharmacology over the 100-year period, we hope that this volume will capture much of the progress in pharmacology,hopingtoprovideawindowtosomeofthepastachievementsaswell as an anticipation of future progress. Perhaps even more importantly, several chapters provide visions for the future of pharmacology. We thank the authors for theircontributionstothisimportantvolumeinthehistoryofthisprestigiousseries, while also expressing our deep appreciation to the many scientists whose passion and commitment to pharmacology have made it a vibrant discipline, translating advancesinbasicsciencetosafeandeffectivetherapeutics. We would also like to express our sincere appreciation to Susanne Dathe, SpringerEditor for Neurosciences/Pharmaceutical Sciences/Protocols,whosecom- mitment and competence have helped to continue the tradition of this remarkable series,andtothepastandcurrenteditorialboardmemberswhohavededicatedtime andeffortintoestablishingthisseriesasoneofthemostrecognizedpublicationsin pharmacology. Philadelphia,PA,USA JamesE.Barrett London,UK CliveP.Page Mainz,Rheinland-Pfalz,Germany MartinC.Michel Contents PartI ACenturyofAdvancesinPharmacology PerspectivesofPharmacologyoverthePast100Years. . . . . . . . . . . . . . 3 JamesE.Barrett,ClivePage,andMartinC.Michel EmergentConceptsofReceptorPharmacology. . . . . . . . . . . . . . . . . . . 17 TerryKenakin TheEvolvingLandscapeofCancerTherapeutics. . . . . . . . . . . . . . . . . . 43 MadehaKhanandJamesSpicer MonoclonalAntibodies:Past,PresentandFuture. . . . . . . . . . . . . . . . . 81 J.Posner,P.Barrington,T.Brier,andA.Datta-Mannan 100YearsofDrugDeliverytotheLungs. . . . . . . . . . . . . . . . . . . . . . . . 143 FedericoLavorini,FrancescaButtini,andOmarS.Usmani IonChannelPharmacologyforPainModulation. . . . . . . . . . . . . . . . . . 161 FrancescoDeLoguandPierangeloGeppetti ExploitingtheDiversityofIonChannels:ModulationofIonChannels forTherapeuticIndications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 YaniLiuandKeWeiWang PartII RecentDevelopmentsandEnablingTechnologiesin Pharmacology GeneticallyEncodedFluorescentCalciumandVoltageIndicators. . . . . 209 IreneMollinedo-Gajate,ChenchenSong,andThomasKnöpfel MechanisticImage-BasedModelling:ConceptsandApplications. . . . . . 231 DenisMenshykauandSimonTanaka Pharmacometabonomics:ThePredictionofDrugEffectsUsing MetabolicProfiling. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263 JeremyR.Everett vii viii Contents TheMicrobiomeandItsPotentialforPharmacology. . . . . . . . . . . . . . . 301 AriesChavira,PedroBelda-Ferre,TomaszKosciolek,FarhanaAli, PieterC.Dorrestein,andRobKnight HarnessingHumanMicrophysiologySystemsasKeyExperimental ModelsforQuantitativeSystemsPharmacology. . . . . . . . . . . . . . . . . . . 327 D.LansingTaylor,AlbertGough,MarkE.Schurdak,LawrenceVernetti, ChakraS.Chennubhotla,DanielLefever,FenPei,JamesR.Faeder, TimothyR.Lezon,AndrewM.Stern,andIvetBahar PartIII TheFutureofPharmacology TheFutureofClinicalTrialDesign:TheTransitionfromHard EndpointstoValue-BasedEndpoints. . . . . . . . . . . . . . . . . . . . . . . . . . . 371 MatthijsD.Kruizinga,FrederikE.Stuurman,GeertJ.Groeneveld, andAdamF.Cohen PlacebosandthePlaceboEffectinDrugTrials. . . . . . . . . . . . . . . . . . . 399 PaulEnckandSibylleKlosterhalfen Pharmacoepidemiology. . . . . . . .. . . . . . . . .. . . . . . . . .. . . . . . . . .. . . 433 NicholasMoore,PatrickBlin,andCécileDroz WhyAreNewDrugsExpensiveandHowCanTheyStayAffordable?. . . 453 BasmaHammelandMartinC.Michel Perspectives of Pharmacology over the Past 100 Years James E. Barrett, Clive Page, and Martin C. Michel Contents 1 Introduction................................................................................... 5 2 TheEmergenceofPharmacologyinGermany:RudolfBuchheim.......................... 5 2.1 Schmiedeberg’sContributiontotheDevelopmentofPharmacology................. 7 3 TheSpreadofPharmacology................................................................. 8 3.1 OttoKrayerandtheOriginsofBehavioralPharmacology............................ 10 4 PharmacologyThrough100YearsandaFuturePerspective................................ 12 5 Conclusions................................................................................... 14 References......................................................................................... 14 Abstract It is fitting that the 100th anniversary of the Handbook of Experimental Pharmacology celebrates not only its founding but also the founding of experi- mental pharmacology as both had their beginnings in Germany. Founded in 1919 by Arthur Heffter (1859–1925) as the “Handbuch der Experimentellen Pharmakologie” and renamed to its current title in 1937, the Handbook has continued to capture the emergence and developments of experimental pharma- cology since the initial systematic work of Rudolf Buchheim and his student Oswald Schmiedeberg. Heffter, the first Chairman of the German Society of Pharmacology, was also responsible for isolating mescaline as the active J.E.Barrett(*) CenterforSubstanceAbuseResearch,LewisKatzSchoolofMedicineatTempleUniversity, Philadelphia,PA,USA e-mail:[email protected] C.Page SacklerInstituteofPulmonaryPharmacology,InstituteofPharmaceuticalScience, King’sCollegeLondon,London,UK M.C.Michel DepartmentofPharmacology,JohannesGutenbergUniversity,Mainz,Germany #SpringerNatureSwitzerlandAG2019 3 J.E.Barrettetal.(eds.),ConceptsandPrinciplesofPharmacology, HandbookofExperimentalPharmacology260,https://doi.org/10.1007/164_2019_334
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