Comprehensive Dermatologic Drug Therapy

1057 Pages·2020·14.312 MB·English

by  Stephen Wolverton, Jashin Wu

Comprehensive Dermatologic
Drug Therapy
FOURTH EDITION
Stephen E. Wolverton, MD
Theodore Arlook Professor of Clinical Dermatology
Department of Dermatology
Indiana University School of Medicine
Indianapolis, Indiana, USA
Associate Editor
Jashin J. Wu, MD
Founder and Course Director
San Diego Dermatology Symposium
May 29-31, 2020;
Founder and CEO
Dermatology Research and Education Foundation
Irvine, California, USA
Elsevier
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COMPREHENSIVE DERMATOLOGIC DRUG THERAPY, FOURTH EDITION ISBN: 978-0-323-61211-1
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This book is dedicated to the following individuals:
To my wife Cheryl, for her support and help over the past 18 months of the
book development and the editorial process, let alone for our 39 years of marriage.
To our sons Dr. Jay Edward Wolverton (age 33) and Justin David Wolverton (age 31),
who continue to enable us to see the world through their creative minds,
kind hearts, and strong relationships.
To my parents Elizabeth Ann (1924–2000) and Dr. George M. Wolverton Sr.
(1925–2011), for the passion, wisdom, compassion, and encouragement provided
throughout their lives; these traits continue to have a positive influence on my life
on a daily basis.
And lastly to my wonderful (and large) nuclear family with three sisters (Anne, Cynthia,
and Pam) and five brothers (George Jr. [1951–1996], Greg, Jeff, Doug, and Dan),
for their kindness to and consideration for others, and their ongoing
camaraderie and generosity.
Stephen E. Wolverton, MD
To my loving wife Stephanie, who lovingly supports my career
over 10 years of marriage.
To my baby boy Conrad, who I hope grows to be a man of maturity, wisdom,
intellect, and strength.
To my parents Shin Wu, MD and Jane Joaquin-Wu, MD, who installed in me the
value of hard work and perseverance: thank you for all that you have given me.
Jashin J. Wu, MD
v
Contributors
David R. Adams, MD, PharmD Jonathan A. Braue, MD
Professor of Dermatology Staff Dermatologist
Department of Dermatology Cleveland Clinic Indian River Hospital
Penn State Hershey Medical Center Scully-Welsh Cancer Center
Hershey, Pennsylvania, USA Vero Beach, Florida, USA
Stewart Adams, MD, FRCP, FAAD Robert T. Brodell, MD
Clinical Lecturer Professor and Chair
Department of Medicine Department of Dermatology
University of Calgary University of Mississippi Medical Center
Calgary, Alberta, Canada Jackson, Mississippi, USA;
Instructor
Mina Amin, MD Department of Dermatology
Department of Dermatology University of Rochester School of Medicine and Dentistry
Kaiser Permanente Los Angeles Medical Center Rochester, New York, USA;
Los Angeles, California, USA Professor
Department of Pathology
Nidhi Avashia-Khemka, MD University of Mississippi Medical Center
Assistant Professor of Clinical Dermatology Jackson, Mississippi, USA
Department of Dermatology
Indiana University School of Medicine David G. Brodland, MD
Indianapolis, Indiana, USA Assistant Professor
Department of Dermatology,
Kristen M. Beck, MD Assistant Professor
Clinical Fellow Department of Otolaryngology,
Psoriasis and Skin Treatment Center Assistant Professor
University of California Department of Plastic Surgery
San Francisco, California, USA University of Pittsburgh
Pittsburgh, Pennsylvania, USA
Bhavnit K. Bhatia, MD
Physician Candace Broussard-Steinberg, MD, BS
Department of Dermatology Resident
The Permanente Medical Group Department of Dermatology
Richmond, California, USA Indiana University School of Medicine
Indianapolis, Indiana, USA
Sravya Mallam Bhatia, MD
Resident Physician Jeffrey P. Callen, MD, FACP, MAAD, MACR
Department of Dermatology Professor of Medicine (Dermatology)
Duke University Medical Center Chief
Durham, North Carolina, USA Division of Dermatology
University of Louisville School of Medicine
Tina Bhutani, MD Louisville, Kentucky, USA
Assistant Professor
Psoriasis and Skin Treatment Center
University of California
San Francisco, California, USA
vi
Contributors vii
Charles Camisa, MD, FAAD Cynthia M.C. DeKlotz, MD, MASt
Director and Founder Assistant Professor of Clinical Medicine and Pediatrics
Psoriasis Treatment Center Internal Medicine and Pediatrics
Riverchase Dermatology Division of Dermatology
Naples, Florida, USA; Georgetown University School of Medicine;
Affiliate Associate Professor Pediatric and Adult Dermatologist
Department of Dermatology and Cutaneous Surgery Department of Dermatology
University of South Florida MedStar Washington Hospital Center/Georgetown University
Tampa, Florida, USA Hospital
Washington, District of Columbia, USA
Ahmad Chehade, PharmD
Clinical Pharmacist Gabrielle-Eugenie Duprat, MD
Calgary, Alberta, Canada Indiana University School of Medicine
Indianapolis, Indiana, USA
Margot Chima, MC
Resident William H. Eaglstein, MD
Department of Dermatology Professor and Chairman Emeritus
Icahn School of Medicine at Mount Sinai The Doctor Phillip Frost Department of Dermatology and
New York, New York, USA Cutaneous Surgery
University of Miami Miller School of Medicine
Richard A. Clark, MD Miami, Florida, USA
Professor
Department of Biomedical Engineering and Dermatology Carly A. Elston, MD
Stony Brook University Assistant Professor
Stony Brook, New York, USA Department of Dermatology
University of Alabama at Birmingham
Abigail Cline, MD, PhD Birmingham, Alabama, USA
Resident Physician
Department of Dermatology Dirk M. Elston, MD
Metropolitan Hospital Professor and Chair
New York, New York, USA Department of Dermatology
Medical University of South Carolina
Kelly M. Cordoro, MD Charleston, South Carolina, USA
Professor of Dermatology and Pediatrics
University of California Ashley N. Emerson, MD
San Francisco, California, USA Assistant Professor
Department of Dermatology
Julio C. Cruz Ramón, MD University of Mississippi Medical Center
Dermatologist and Dermatopathologist Jackson, Mississippi, USA
Buckeye Dermatology
Dublin, Ohio, USA Stephanie K. Fabbro, MD
Attending Dermatologist
Loretta S. Davis, MD Department of Dermatology
Professor and Chair Buckeye Dermatology
Department of Dermatology, Columbus, Ohio, USA
Residency Program Director
Medical College of Georgia Steven R. Feldman, MD, PhD
Augusta University Professor
Augusta, Georgia, USA Department of Dermatology
Wake Forest School of Medicine
Salma de la Feld, MD Winston-Salem, North Carolina, USA
Assistant Professor
Department of Dermatology Laura K. Ferris, MD, PhD
Emory University Associate Professor of Dermatology
Augusta, Georgia, USA University of Pittsburgh
Pittsburgh, Pennsylvania, USA
Kelly A. Foley, PhD
Medical Research Associate
Department of Dermatology
Mediprobe Research Inc.
London, Ontario, Canada
viii Contributors
Seth B. Forman, MD Aditya K. Gupta, MD, PhD, FRCP(C)
Dermatologist Professor
Dermatology Division of Dermatology, Department of Medicine
Department of ForCare Medical Group University of Toronto
Tampa, Florida, USA Toronto, Ontario, Canada;
Director
Craig Garofola, DO Mediprobe Research Inc.
PGY4 Dermatology Resident London, Ontario, Canada
Virginia College of Osteopathic Medicine/Lewis Gale
Montgomery Anita Haggstrom, MD
Blacksburg, Virginia, USA Associate Professor
Department of Dermatology
Jeffrey R. Gehlhausen, MD, PhD Indiana University
Resident Physician Indianapolis, Indiana, USA
Department of Dermatology
Yale New Haven Hospital Christopher T. Haley, MD
New Haven, Connecticut, USA Clinical Research Fellow
Department of Dermatology
Joel M. Gelfand, MD, MSCE Center for Clinical Studies
Professor of Dermatology and Epidemiology Webster, Texas, USA
Departments of Dermatology and Biostatisitcs, Epidemiology
and Informatics Russell P. Hall III, MD
University of Pennsylvania Perelman School of Medicine J. Lamar Callaway Professor and Chair
Philadelphia, Pennsylvania, USA Department of Dermatology
Duke University Medical Center
Michael Girardi, MD Durham, North Carolina, USA
Professor, Vice Chair, and Residency Program Director
Department of Dermatology Iltefat Hamzavi, MD, FAAD
Yale School of Medicine Senior Staff Physician
New Haven, Connecticut, USA Department of Dermatology
Henry Ford Health System;
Tobias Goerge, MD Clinical Associate Professor
Professor of Dermatology Wayne State University SOM
Department of Dermatology Detroit, Michigan, USA
University of Münster
Münster, Germany Michael P. Heffernan, MD
US Dermatology Lead
Kenneth B. Gordon, MD Department of Dermatology
Professor and Chair Probity Medical Research
Department of Dermatology San Luis Obispo, California, USA
Medical College of Wisconsin
Milwaukee, Wisconsin, USA Yolanda R. Helfrich, MD
Associate Professor
Teri M. Greiling, MD, PhD Department of Dermatology
Assistant Professor University of Michigan Medical School
Department of Dermatology Ann Arbor, Michigan, USA
Oregon Health and Science University
Portland, Oregon, USA Adam B. Hessel, MD
Adjunct Assistant Professor
Erin E. Grinich, MD Department of Dermatology
Resident Physician The Ohio State University
Department of Internal Medicine Columbus, Ohio, USA;
Loma Linda University Medical Center Dermatologist and Dermatopathologist
Loma Linda, California, USA Buckeye Dermatology
Dublin, Ohio, USA
Daniel Grove, MD
Resident Shauna Higgins, MD
Department of Dermatology Clinical Research Fellow
Indiana University Department of Dermatology
Indianapolis, Indiana, USA University of Nebraska Medical Center
Omaha, Nebraska, USA
Contributors ix
Whitney A. High, MD, JD, MEng Hee Jin Kim, MD
Professor and Vice Chairman Dermatology Resident
Departments of Dermatology and Pathology Department of Dermatology
University of Colorado Icahn School of Medicine at Mount Sinai
Denver, Colorado, USA New York, New York, USA
Katherine Hrynewycz, BS, MD Sa Rang Kim, MD
Dermatology Resident Department of Dermatology
Department of Dermatology Yale School of Medicine
Indiana University New Haven, Connecticut, USA
Indianapolis, Indiana, USA
Melanie Kingsley, MD
Sylvia Hsu, MD Director of Cosmetic Dermatology and Laser Surgery
Professor and Chair Department of Dermatology
Department of Dermatology Indiana University School of Medicine
Temple University Lewis Katz School of Medicine Indianapolis, Indiana, USA
Philadelphia, Pennsylvania, USA
Sandra R. Knowles, BScPhm [Retired]
Michael J. Huether, MD Drug Information Pharmacist
Medical Director Department of Pharmacy
Mohs Micrographic Surgery Sunnybrook Health Sciences Centre
Arizona Skin Cancer Surgery Center, P.C. Toronto, Ontario, Canada
Tucson, Arizona, USA
John Y.M. Koo, MD
Michael J. Isaacs, MD Professor
Physician Psoriasis and Skin Treatment Center
Department of Dermatology University of California
Indiana University School of Medicine San Francisco, California, USA
Indianapolis, Indiana, USA
Carol L. Kulp-Shorten, MD
Michael S. Kaminer, MD Clinical Professor of Medicine (Dermatology)
Associate Clinical Professor Departments of Medicine/Dermatology
Department of Dermatology University of Louisville School of Medicine
Yale Medical School Louisville, Kentucky, USA
New Haven, Connecticut, USA;
Assistant Clinical Professor Megan N. Landis, MD
Department of Dermatology Clinical Associate Professor of Dermatology
Brown Medical School Department of Medicine
Providence, Rhode Island, USA Division of Dermatology
University of Louisville
Prasanthi Kandula, MD Louisville, Kentucky, USA;
Department of Dermatology Dermatologist
SkinCare Physicians Department of Dermatology
Chestnut Hill, Massachusetts, USA The Dermatology and Skin Cancer Center of Southern Indiana
Corydon, Indiana, USA
Swetha Kandula, MD, FAAD
Founder Mark G. Lebwohl, MD
Dermatology and Skincare Arts Chairman
Parsippany, New Jersey, USA Department of Dermatology
Icahn School of Medicine at Mount Sinai
Sewon Kang, MD, MPH New York, New York, USA
Noxell Professor and Chairman
Department of Dermatology Erica B. Lee, MD
Johns Hopkins School of Medicine Department of Internal Medicine
Baltimore, Maryland, USA Santa Barbara Cottage Hospital
Santa Barbara, California, USA
Marshall B. Kapp, JD, MPH
Director and Professor Emeritus
Center for Innovative Collaboration in Medicine and Law
Florida State University
Tallahassee, Florida, USA
x Contributors
Katherine B. Lee, MD David Martell, DO
Assistant Clinical Professor Chief of Dermatology
Department of Dermatology Department of Medicine
University of California, Irvine Irwin Army Community Hospital
Irvine, California, USA; Fort Riley, Kansas, USA
Medical Director
Halcyon Dermatology Rachel R. Mays, BSc
Laguna Hills, California, USA Research Associate
Department of Dermatology
Amy B. Lewis, MD Mediprobe Research Inc.
Clinical Assistant Professor London, Ontario, Canada
Department of Dermatology
Yale University School of Medicine Linda F. McElhiney, PharmD, RPh, MSP
New Haven, Connecticut, USA Team Lead Compounding Pharmacist
Compounding Pharmacy
Geoffrey F.S. Lim, MD Indiana University Health
Medical Director Indianapolis, Indiana, USA
Mohs Micrographic Surgery and Dermatologic Oncology
OptumCare Medical Group Ginat W. Mirowski, DMD, MD
Colorado Springs, Colorado, USA Adjunct Associate Professor
Department of Oral Pathology, Medicine Radiology
Henry W. Lim, MD Indiana University School of Dentistry;
Former Chair Clinical Professor
Department of Dermatology Department of Dermatology
Henry Ford Hospital; Indiana University School of Medicine
Senior Vice President for Academic Affairs Indianapolis, Indiana, USA
Henry Ford Health System
Detroit, Michigan, USA Shoko Mori, MD
Research Fellow
Benjamin N. Lockshin, MD Dermatology Service
Director of the Clinical Trials Center Memorial Sloan Kettering Cancer Center
U.S. Dermatology Partners New York, New York, USA
Rockville, Maryland, USA;
Assistant Professor Kiran Motaparthi, MD
Department of Dermatology Associate Professor
Georgetown University Department of Dermatology
Washington, Maryland, USA University of Florida College of Medicine
Gainesville, Florida, USA
Thomas A. Luger, MD
Professor of Dermatology Uyen Ngoc Mui, MD
Department of Dermatology Clinical Research Fellow
University of Münster Department of Dermatology
Münster, Germany Center for Clinical Studies
Houston, Texas, USA
Jacquelyn Majerowski, MD, BS
Resident, PGY-4 Christian Murray, MD, FRCPC
Department of Dermatology Associate Professor
Medical College of Wisconsin Departments of Dermatology/Medicine
Milwaukee, Wisconsin, USA University of Toronto
Toronto, Ontario, Canada
Lawrence A. Mark, MD, PhD
Associate Professor of Clinical Dermatology Colton Nielson, MD
Department of Dermatology Resident Physician
Indiana University School of Medicine Department of Dermatology
Indianapolis, Indiana, USA University of Florida
Gainesville, Florida, USA
Dana Marshall, MD, FAAD
Board Certified Dermatologist Megan H. Noe, MD, MPH, MSCE
Klinger and Marshall Dermatology Clinical Instructor
Gretna, Louisiana, USA Department of Dermatology
University of Pennsylvania
Philadelphia, Pennsylvania, USA
Contributors xi
Ginette A. Okoye, MD Dana L. Sachs, MD
Professor and Chair Professor
Department of Dermatology Department of Dermatology
Howard University College of Medicine University of Michigan
Washington, District of Columbia, USA Ann Arbor, Michigan, USA
Cindy England Owen, MD, MS Naveed Sami, MD
Associate Clinical Professor Professor
Department of Dermatology Departments of Internal Medicine and Dermatology
University of Louisville University of Central Florida
Louisville, Kentucky, USA Orlando, Florida, USA
Timothy Patton, DO Marty E. Sawaya, MD, PhD
Assistant Professor of Dermatology President
Department of Dermatology Department of Dermatology
University of Pittsburgh Sujo Co.
Pittsburgh, Pennsylvania, USA Ocala, Florida, USA
Warren W. Piette, MD Courtney R. Schadt, MD
Chair Associate Professor
Division of Dermatology Division of Dermatology
Department of Internal Medicine University of Louisville
John H. Stroger, Jr. Hospital of Cook County; Louisville, Kentucky, USA
Professor
Department of Dermatology William Schaffenburg, MD
Rush University Medical Center Department of Dermatology
Chicago, Illinois, USA Walter Reed National Military Medical Center
Bethesda, Maryland, USA
Sahand Rahnama-Moghadam, MD, MS
Assistant Professor of Dermatology Bethanee J. Schlosser, MD, PhD
Department of Dermatology Assistant Professor
Indiana University Department of Dermatology
Indianpolis, Indiana, USA Northwestern University
Chicago, Illinois, USA
Sarika Manoj Ramachandran, MD, FAAD
Assistant Professor Sahil Sekhon, MD
Yale University School of Medicine Resident Physician
New Haven, Connecticut, USA Department of Dermatology
Howard University
Elizabeth A. Rancour, MD Washington, District of Columbia, USA
Dermatologist
Private Practice Vidhi V. Shah, MD
Missouri Dermatology Laser and Vein Center Department of Dermatology
St. Louis, Missouri, USA University of South Florida
Tampa, Florida, USA
Jaggi Rao, MD, FRCPC
Board Certified Dermatologist Lori E. Shapiro, MD, FRCPC
Clinical Professor of Medicine Staff Physician
University of Alberta Department of Dermatology
Edmonton, Alberta, Canada Department of Clinical Pharmacology
Drug Safety Clinic
Misha Rosenbach, MD Sunnybrook Health Sciences Centre
Associate Professor of Dermatology and Internal Medicine Toronto, Ontario, Canada
Vice Chair, Education and Training
Director, Dermatology Inpatient Consult Service Neil H. Shear, BASc, MD, FRCPC, FACP
Perelman School of Medicine at the University of Pennsylvania Professor
Philadelphia, Pennsylvania, USA Department of Medicine (Dermatology, Clinical Pharmacology)
University of Toronto;
Katherine Roy, MD Dermatologist-in-Chief
Dermatologist, Dermatopathologist Department of Dermatology
Dermatology Group of the Carolinas Sunnybrook Health Sciences Centre
Concord, North Carolina, USA Toronto, Ontario, Canada
xii Contributors
Michael Sheehan, MD Stephen K. Tyring, MD, PhD, MBA
Dermatology Physicians Inc. Clinical Professor
Columbus, Indiana, USA Department of Dermatology
University of Texas Health Science Center;
Eric L. Simpson, MD, MCR Medical Director
Professor Department of Dermatology
Department of Dermatology Center for Clinical Studies
Oregon Health and Science University Houston, Texas, USA
Portland, Oregon, USA
Kaitlin Vogt-Schiavo, MD
Alexandra Snodgrass, MD Department of Dermatology
Department of Dermatology Indiana School of Medicine
University of Florida College of Medicine Indianapolis, Indiana, USA
Gainesville, Florida, USA
Raj Vuppalanchi, MBBS
Nowell Solish, MD FRCP Professor of Medicine
Assistant Professor Department of Medicine–Gastroenterology
Department of Dermatology Indiana University School of Medicine
University of Toronto Indianapolis, Indiana, USA
Toronto, Ontario, Canada
Steve Q. Wang, MD
Ally-Khan Somani, MD, PhD Director of Dermatologic Surgery and Dermatology
Assistant Professor, Dermatology Service
Director of Dermatologic Surgery and Cutaneous Oncology, Memorial Sloan Kettering Cancer Center
Director of Micrographic Surgery and Dermatologic Oncology New York, New York, USA
Dermatology,
Adjunct Assistant Professor of Otolaryngology Gillian Weston, MD
Department of Otolaryngology-Head and Neck Surgery Department of Dermatology
Indiana University School of Medicine University of Connecticut Health Center
Indianapolis, Indiana, USA Farmington, Connecticut, USA
Najwa Somani, MD, FRCPC Stephen E. Wolverton, MD
Assistant Professor Theodore Arlook Professor of Clinical Dermatology
Department of Dermatology Department of Dermatology
Indiana University School of Medicine Indiana University School of Medicine
Indianapolis, Indiana, USA Indianapolis, Indiana, USA
Bruce Strober, MD, PhD Jashin J. Wu, MD
Department of Dermatology Founder and Course Director
Yale University San Diego Dermatology Symposium
New Haven, Connecticut, USA May 29-31, 2020;
Founder and CEO
Mathias Sulk, MD Dermatology Research and Education Foundation
Department of Dermatology Irvine, California, USA
University of Münster
Münster, Germany Ashley Wysong, MD, MS
Founding Chairman
Kathleen C. Suozzi, MD William W. Bruce MD Distinguished Chair of Dermatology
Assistant Professor, Department of Dermatology
Director, Aesthetic Dermatology University of Nebraska Medical Center
Department of Dermatology Omaha, Nebraska, USA
Yale School of Medicine
New Haven, Connecticut, USA John Zic, MD, MMHC
Professor of Dermatology
Michael D. Tharp, MD Department of Dermatology
Chair and Professor Emeritus Vanderbilt University Medical Center
Department of Dermatology Nashville, Tennessee, USA
Rush University Medical Center
Tampa, Florida, USA Jeffrey P. Zwerner, MD, PhD
Assistant Professor
Mary M. Tomayko, MD, PHD Department of Dermatology
Associate Professor Vanderbilt University
Departments of Dermatology and Pathology Nashville, Tennessee, USA
Yale University School of Medicine
New Haven, Connecticut, USA