Complete Companion For GPAT & Other Competitive Examinations In Pharmacy

809 Pages·2019·32.892 MB·English

by  Umang Shah, Ashok Akarbari, Amit Kumar Baser

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Complete Companion for
GPAT
and
Other Entrance Examination in Pharmacy
Fourth Edition
Umang Shah
Ashok Akabari
Amit Kumar Baser
Ashish Patel
A01_SHAH1057_01_FM.indd 3 4/15/2019 4:18:30 PM
Copyright © 2019 Pearson India Education Services Pvt. Ltd

Published by Pearson India Education Services Pvt. Ltd, CIN: U72200TN2005PTC057128.

No part of this eBook may be used or reproduced in any manner whatsoever without the publisher’s
prior written consent.

This eBook may or may not include all assets that were part of the print version. The publisher
reserves the right to remove any material in this eBook at any time.

ISBN 978-93-534-3431-1
eISBN:
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Contents
Preface ix
Acknowledgements x
Syllabus for GPAT xi
About the Examination xxvii
Graduate Pharmacy Aptitude Test – 2019 xxviii
Graduate Pharmacy Aptitude Test – 2018 xxxvii
UNIT 1: PHARMACEUTICS Formulation of Tablets 1.50
Capsule 1.65
Chapter 1 Physical Pharmaceutics 1.3
Parenterals 1.67
Micromeritics and Powder Rheology 1.3
Aerosols 1.72
Surface and Interfacial Phenomenon 1.9
Sterilization and Disinfectants 1.74
Rheology 1.13
Controlled Drug Delivery System 1.78
State of Matter 1.16
Chapter 4 Dispensing Pharmacy 1.93
Colloids 1.17
Pharmaceutical Calculation 1.93
Diffusion 1.19
Microencapsulation 1.96
Chapter 2 Pharmaceutical Engineering
(Unit Operation) 1.24 Liquid and Semisolid Dosage Forms 1.97
Size Reduction 1.24 Drug Incompatibility 1.102
Size Separation 1.25 Chapter 5 Biopharmaceutics 1.110
Drying 1.25 Absorption of Drug 1.110
Crystallization 1.29 Theories of Dissolution 1.111
Evaporation 1.30 Pharmacokinetic Models 1.116
Mixing 1.30 Physiologic Model 1.116
Filtration 1.31 Michaelis Menten Equation 1.123
Centrifugation 1.32 In-Vitro In-Vivo Correlation 1.126
Heat and Mass Transfer 1.33 Chapter 6 Jurisprudence 1.133
Distillation 1.33 Chapter 7 Cosmetics Preparation 1.143
Flow of Fluids 1.34 Cosmetics 1.143
Extraction 1.35 Chapter 8 Microbiology 1.153
Chapter 3 Pharmaceutical Technology and Modern Definitions 1.153
Pharmaceutics 1.41 Chemical Nature of Immunogens 1.153
Preformulation 1.41 Immunoglobulins–Structure and
Tablet 1.49 Function 1.154
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vi  Contents
Immunity 1.156 Antiviral Agents 2.59
Classification and Identification of Anti-Herpes Agent 2.60
Bacteria 1.159 Chemotherapy of Cancer 2.61
Staining Methods in Microbiology 1.160 Chapter 6 Therapeutic Aspect of Inflammatory
Few Important Assay 1.161 Disorders 2.72
Non-Steroidal Anti-Inflammatory
Genetic Recombination in Bacteria 1.162
Drugs and Antipyretic–Analgesics 2.72
Antibiotics—Microbial Assays 1.163
Drugs for Cough 2.73
Asthma 2.74
UNIT 2: PHARMACOLOGY
Eicosanoids 2.75
Chapter 7 Drugs Acting on Cardio-Vascular
Chapter 1 Basic Pharmacology 2.3
System 2.80
Pharmacology and Routes of
Anti Hypertensive Drugs 2.80
Administration 2.3
Drugs used to treat CHF 2.81
Pharmacokinetics 2.4
Anti-Anginal Drugs 2.83
Pharmacodynamics 2.6
Anti-Arrhythmic Agent 2.84
Chapter 2 Autonomic Nervous System 2.11
Drugs Affecting Coagulation,
Antiadrenergic Drugs 2.17 Bleeding time and Thrombosis 2.87
Chapter 3 Endocrine Pharmacology 2.23 Agents used in Hyperlipidemia 2.90
Anterior Pituitary Hormones 2.23 Diuretics 2.91
Oxytocin and Drug Acting on Uterus 2.25 Chapter 8 Drugs for Gastrointestinal Tract
Thyroid and Parathyroid Hormones 2.25 Disorder 2.101
Drugs for Peptic Ulcer 2.101
Oral Hypoglycaemics 2.28
Emetics and Antiemetics 2.102
Chapter 4 Central Nervous System 2.34
Chapter 9 Pharmacological Drugs
Sedative Hypnotics 2.34
Classification 2.106
Antiepileptic Drugs 2.35
Drugs Acting at Autonomic Nervous
Antiepileptic Drugs 2.36 System 2.106
Anti Parkinson’s Drugs 2.37 Cardio-Vascular Drugs 2.106
Chapter 5 Chemotherapy and Chemotherapy Diuretics 2.107
of Cancer 2.46
Histamine, Serotonin and Ergot
Beta Lactam Antibiotics 2.46 Alkaloids 2.107
Chloramphenicol 2.48 Vasoactive Peptide 2.107
Tetracycline 2.48 Prostaglandins and Eicosanoids 2.107
Aminoglycoside Antibiotics 2.49 Anti-asthmatic Drugs 2.107
Macrolides and others Antibiotics 2.49 Drugs Acting at CNS 2.107
Other Antibiotics 2.50 Drugs Acting on Blood, Inflammation
Sulfonamides 2.51 and Gout 2.109
Antitubercular Drugs 2.52 Endocrine Drugs 2.109
Antileprotic Drugs 2.53 Chemotherapy 2.110
Antifungal Drugs 2.54 Anti Cancer Drugs 2.112
Antihelmintics 2.55 Immunosuppresants 2.112
Anti Amoebic and other Antiprotozoal Immunostimulators 2.112
Drugs 2.58 Drugs used in Gastrointestinal
Drug for Leishmaniasis 2.59 Disorders 2.112
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Contents  vii
UNIT 3: PHARMACEUTICAL Terpenoids 4.8
CHEMISTRY Plant hormone 4.8
Enzymes 4.16
Chapter 1 Physical Chemistry 3.3
Papain 4.16
Thermodynamic and Energetics 3.3
Bromelain 4.16
Kinetics of a Reaction 3.6
Streptokinase 4.17
Kinetic Theory of Gases and Solution
Urokinase 4.17
Chemistry 3.9
Hyaluronidase 4.17
Methods of Expressing the Concentration
of a Solution 3.13 Serratiopeptidase 4.18
Electrochemistry 3.16 Gelatin 4.18
Acid-Base and Ionic Equilibrium 3.18 Chapter 2 Drug Containing Alkaloids 4.23
Radioactivity 3.22 Alkaloidal Drugs Description 4.23
Chapter 2 Organic Chemistry 3.27 Chapter 3 Drug Containing Glycosides 4.33
Atomic Structure 3.27 Glycosides Drugs Description 4.33
Chapter 3 Analytical Chemistry 3.86 Microscopy and Adulteration of
Glycosides 4.36
Pharmaceutical Analysis 3.86
Chapter 4 Drug Containing Terpenoids 4.45
Chapter 4 Biochemistry 3.146
Terpenoid Drugs Description 4.45
Carbohydrates 3.146
Microscopy and Adulteration
Important Biochemistry Pathway
of Terpenoids 4.47
(Cycle) 3.162
Chapter 5 Drug Containing Carbohydrate,
Chapter 5 Medicinal Chemistry 3.184
Resin and Tannin 4.55
Drugs Acting on ANS 3.184
Drug Containing Carbohydrate 4.55
Chemotherapy 3.215
Drug Containing Resin 4.57
Cephalosporin 3.218
Tannin 4.59
Macrolide Antibiotics 3.218
Chloramphenicol 3.219
UNIT 5: NIPER SPECIAL
Aminoglycoside 3.220
Steroids 3.236
NIPER – Seats Matrix 5.3
Chapter 6 Inorganic Chemistry 3.275
Master Programme for 2016–2017 5.3
Topical Preparation 3.275
NIPER JEE – Examination Syllabus 5.6
Inorganic Gases 3.276
NIPER Special 5.11
Gastro Intestine Agents 3.277
Isosteres 5.11
Protective and Adsorbents 3.277
Therma Method of Analysis 5.14
Saline Cathartics 3.277
Instrument 5.14
Acid Base and Buffers 3.278
Major Regulatory Agencies World Wide 5.27
Miscellaneous Agent 3.279
NIPER JEE – Question Paper I 5.40
NIPER JEE – Question Paper II 5.46
UNIT 4: PHARMACOGNOSY
NIPER JEE – Question Paper III 5.52
Chapter 1 Introduction to Pharmacognosy 4.3 NIPER JEE – Question Paper IV 5.58
Alkaloids 4.3 NIPER JEE – Question Paper V 5.64
Glycosides 4.7 Some Tips for Preparation of NIPER JEE and GPAT 5.70
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viii  Contents
UNIT 6: PREvIOUS YEARS’ SOLvEd 3. UPSC Drug Inspector Examination Paper 2011 6.15
PAPERS 4. Gujarat Government Lecturer Examination
in Degree/Diploma Pharmacy College-GPSC
1. L. M. College of Pharmacy, Gujarat (Government 2010 6.24
of Gujarat) Assistant Professor Recruitment
5. Gujarat Drug Inspector Exam Paper—GPSC 2010 6.30
Examination Question Paper 2016 6.3
6. GPAT Paper 2017 6.36
2. ESIC Pharmacist (Employees State Insurance
7. GPAT Paper 2012 6.46
Corporation -Allopathic) Recruitment Question
Paper 2016 6.9
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Preface
The Graduate Pharmacy Aptitude Test (GPAT) is an online national level entrance examination for admission into all post
graduate pharmacy programs conducted by National Testing Agency (NTA) since 2018. NTA is an autonomous and self-
sustained premier testing organization for major entrance examinations in higher educational institutions. [Earlier GPAT
was approved and conducted by the All India Council for Technical Education (AICTE)].
This examination is usually conducted annually for admission to the postgraduate courses in the affiliated institutes
of AICTE and University Grants Commission (UGC). The GPAT score is also recommended for appearing in the
National Institute of Pharmaceutical Education and Research (NIPER) examination and Ph.D. Programmes in various
universities.
The Complete Companion for GPAT and Other Entrance Examination in Pharmacy in its fourth edition, is a sincere
accomplishment to produce comprehensive course material for the aspirants. The book contains six units, where the first
four units are covering major sections of pharmaceutics, pharmacology, pharmaceutical chemistry, and pharma cognosy.
Unit five contains all important information regarding NIPER JEE examination—syllabus, preparation guidelines, and five
mock test papers particularly designed for NIPER JEE in line with previous years’ examination. All previous years’ solved
papers from GPAT, GPSC and UPSC examination’s Drug Inspector; government lecturer and pharmacist’s examination
are included in unit six. GPAT 2019, 2018, and 2017 solved question papers are included in front matter of the book. Five
updated mock-tests have been uploaded online (https://www.pearsoned.co.in/UmangHShah/) for further practice. Each
chapter of the book is supported with highlighted definitions, theoretical explanations with diagrams, tabular data for
effective preparations. Chapter-end exercises are graded from simple to moderate to difficult as per the previous years’
questions from GPAT, GATE, and NIPER JEE.
This book is also useful for various entrance examinations such as Gujarat Public Service Commission (GPSC),
Maharashtra CET (MHCET); Manipal University, and Union Public Service Commission (UPSC) examinations for Drug
Inspector; government lectureship.
We hope this book will help students understand the concepts and enable them to solve maximum questions in
minimum time.
Finally, we wish all the very best to every student preparing for the GPAT examination.
Umang Shah
Ashok Akabari
Amit Baser
Ashish Patel
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