Combination formulation of two antiviral compounds

46 Pages·2014·3.37 MB·English

US 20140212491A1
(19) United States
(12) Patent Application Publication (10) Pub. No.: US 2014/0212491 A1
Chal et al. (43) Pub. Date: Jul. 31, 2014
(54) COMBINATION FORMULATION OF TWO cation No. 61/870,729, ?led on Aug. 27, 2013, provi
ANTIVIRAL COMPOUNDS sional application No. 61/897,793, ?led on Oct. 30,
2013, provisional application No. 61/907,332, ?led on
(71) Applicant: GILEAD PHARMASSET LLC, Foster Nov, 21, 2013,
City, CA (US)
Publication Classi?cation
(72) Inventors: Ben Chal, Millbrae, CA (US); Erik
Mogalian, San Francisco, CA (US); (51) Int. Cl.
Reza Oliyai, Burlingame, CA (US); A61K 31/7072 (2006.01)
Rowchanak Pakdaman, San Carlos, CA A61K 31/4 709 (2006.01)
(US); Dimitrios Stefanidis, Mountain A61K 31/7056 (2006.01)
View, CA (US); Vahid Zia, San Carlos, A61K 31/4184 (2006.01)
CA (US) A61K 9/28 (2006.01)
(52) US. Cl.
(21) Appl. No.: 14/168,264 CPC ....... .. A61K31/7072 (2013.01); A61K31/4184
(2013.01); A61K 9/28 (2013.01); A61K
(22) Filedr Jan- 30, 2014 31/7056 (2013.01); A61K31/4709 (2013.01)
USPC ........................................... .. 424/474; 514/51
Related US. Application Data
(60) Provisional application No. 61/759,320, ?led on Jan. (57) ABSTRACT
31, 2013, provisional application No. 61/772,292, Disclosed are pharmaceutical compositions having an effec
?led on Mar. 4, 2013, provisional application No. tive amount of substantially amorphous ledipasvir and an
61/828,899, ?led on May 30, 2013, provisional appli effective amount of substantially crystalline sofosbuvir.
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