Clinical Studies of Certain Ayurvedic Formulations in the Management of Paraplegia (Pangu)

198 Pages·2008·4.44 MB·English

by  Central Council for Research in Ayurveda and Siddha (India)

CLINICAL STUDIES OF CERTAIN AYURVEDIC
FORMULATIONS IN THE MANAGEMENT OF
PARAPLEGIA (PA×GU)

Central Council for Research in Ayurveda and Siddha
Department of AYUSH, Ministry of Health and Family Welfare
Government of India

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CLINICAL STUDIES OF CERTAIN AYURVEDIC
FORMULATIONS IN THE MANAGEMENT OF
PARAPLEGIA (PA×GU)

EDITORIAL BOARD

EDITOR-IN-CHIEF

Prof.G.S.Lavekar
Director General

EXECUTIVE EDITOR

Dr. M.M. Padhi
Deputy Director (Tech.),

EDITORIAL EXPERTS
Dr.Rakesh Kumari Gulia, M.DMed.), Safdarjung Hospital, New Delhi
Dr. Ravi Yadav, Assistant Professor Neurology, NIMHANS, Bangalore.
Dr. Bheema Bhat, Sr. Consultant & HOD, Ayurveda, Holy Family Hospital, New Delhi.
Prof. R. S. Sharma, HOd, Deptt. Of Panchakarma, NIA, Jaipur.
EDITORS
Dr. M. Mruthyumjaya Rao, Director Institute (Ay.)
Dr.N.Srikanth, Assistant Director (Ay.)
Dr. N. Jaya, Deputy Director (Ay)
Dr.S.Gaidhani, Assistant Director (Pharmacology.)
Dr. Sobaran Singh, Assistant Director (Ay.)
Dr. Banamali Das, Research Officer (Ay.)
Dr. G.C.Bhuyan, Research Officer (Ay.)
Dr. Sarada Ota, Research Officer (Ay.)
Dr.B.Venkateshwarlu, Research Officer (Ay.)
Dr.S.K.Vedi, Research Officer (Ay.)

CENTRAL COUNCIL FOR RESEARCH IN AYURVEDA AND SIDDHA
Department of AYUSH, Ministry of Health and Family Welfare, Government of India
J.L.N.B.C.A.H.Anusandhan Bhavan, 61-65, Institutional Area,
Opp. D-Block, Janakpuri, New Delhi – 110 058
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EDITORIAL SUPPORT

Dr.Sulochana, Assistant Director (Ay.)

Dr. B.S. Sharma, Research Officer (Ay.)

Dr. M.M. Sharma, Research Officer (Ay.)

Dr. K. Prameela Devi, Research Officer (Ay.)
CORE TECHNICAL GROUP

Dr. V A Prabhakaran, Asst. Director (Ay)

Dr. P Madhavikutty, Asst. Director (Ay.)

Dr. V. C. Deep, Asst. Director (Ay.)

Dr.YR Sanjay Kumar, Asst. Director (P’cology.)

Dr. PKS Nair, Asst. Director (Ay.)

Dr. Achintya Mitra, Research Officer (Ay.)

Dr. G. Kusuma, Research Officer (Ay.)

Mr.N. Thamizh Selvam, Research Officer (Biochem.)
TECHNICAL SUPPORT

Dr.Babita Yadav, Senior Research Fellow (Ay.)

Dr. Tanuja Prasad, Senior Research Fellow (Ay.)

Dr. Rajesh Kumar Singh,, Senior Research Fellow (Ay.)

Dr. Suprabhat Bhardwaj, Senior Research Fellow (Ay.)

Dr. Nikhil Jirankalgikar, Senior Research Fellow (Ay.)

Dr.Pallavi Deshmukh, Senior Research Fellow (P’cology)
STATISTICAL ANALYSIS
Sh.R.K.Singhal, Statistical Officer
Sh.R.K.Rana, Statistical Assistant
Ms.Richa Singhal, SRF [Bio-Statistics]
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Publisher

Central Council for Research in Ëyurveda and Siddha
Department of AYUSH, Ministry of Health and Family Welfare, Government of India
J.L.N.B.C.A.H.Anusandhan Bhavan, 61-65, Institutional Area
Opp. D-Block, Janakpuri, New Delhi, 110 058
E-mail :
PARTICIPATED INSTITUTES

Central Research Institute (Ay.), Cheruthuruthy.
Regional Research Institute (Ay.), Nagpur

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INVESTIGATORS

1. Dr.P.Ramachandran Nair A.D(Ay.) 8. Dr.T.V.Menon, A.D(Ay.) (Retired)
(Retired) 9. Dr.P.K.N.Namboodiri, A.D(Ay.)
2. Dr.P.Madhavikutty, R.O (Ay) (Retired),
3. Dr.N.Jaya, A.D(Ay.) i/c 10. Dr.B.Rama Rao, Director(Ay.)
4. Dr.V.A.Prabhakaran, A.D(Ay.) (Retired)
5. Dr.S.S.Nair, R.O (Ay) 11. Dr.S.N. Murthy, A.D(Ay.) i/c, RRI,
6. Dr.T.L.Tersia, R.O (Ay) Nagpur
7. Dr.L.K.Sharma, A.D(Ay.) i/c, RRI,
Nagpur

CO-INVESTIGATORS

1. Dr.N.P.Vijayan, R.O (Pathology) 10. Dr. S.Indirakumari, R.O (Ay)
2. Dr.R.B.Nair, A.D (Biochem.) 11. Dr.V.C.Deep, R.O (Ay)
3. Dr.P.G.Bottliwala, A.D (Biochem.) 12. Dr.V.Subhose, R.O (Ay)
4. Mr.B.Ravisankar, A.R.O, 13. Dr.K.Shanthakumari, R.O (Ay)
(Pharmacology) 14. Dr.G.Venkateswarlu, R.O (Ay)
5. Dr.M.M.Alam, A.D (Biochem.) 15. Dr.T.Maheswar, R.O (Ay)
6. Mr.Muniswamy, R.O (Biochem.) 16. Dr.Kiran.V.Kale, R.O (Ay)
7. Mr.Rajaravivarma, A.D 17. Dr. B.N. Sharma, R.O. (Ay)
(Pharmacology) 18. Dr. (Mrs) L. Sharma, R.O. (Ay)
8. Mr.N.Thamizhselvam, R.O 19. Dr. G.P. Prasad, A.R.O. (Ay)
(Biochem.) 20. Dr. K.K.Pandey, A.R.O. (Ay)
9. Dr.Y.R.Sanjayakumar, R.O 21. Dr. M.N. Suryavamshi, R.O. (Ay)
(Pharmacology) 22. Dr. Savita Sharma, R.O. (Ay)

SUPPORTING LABORATORY STAFF

1. Mrs.A.Chandrika, Statistical Assistant 6. Smt.Sangita Ramteke, Lab. Technician –
2. Mrs.V.N.Sarasvathi, Lab. Technician RRI, Nagpur
3. Mrs.C.K.Sasikala, Lab. Technician 7. Mrs.C.V.Sukumari, Secretarial Asst.
4. Mr.P.T.Pankajavally, Lab. Technician 8. Kum. Mamata Jain, Lab. Technician
5. Mr.T.N.Venugopal, Lab. Technician 9. Shri. N.D. Raut, Lab. Technician

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PREFACE

Paraplegia is a condition in which the lower part of a person’s body is paralyzed
and is usually as a result of spinal cord injury. Nerve joining the spinal cord above the
level of injury or pathological lesion will be unaffected and continue to work as normal.
The disaese paraplegia may be compared with Pa´gu of Ayurvedic literature. The details
of the aetiology, clinical features, prognosis and management etc. have vividly been
described in Ayurvedic classics. On the basis of classical literature, clinical knowledge,
practice and result of preliminary research, four intensive clinical research trials were
designed and conducted at two peripheral institutes of the Council.
Both áodhana and áamana principles were followed in four different studies.
Conventional Paµcakarma therapies as well as selected herbo-mineral formulations were
used for the study. In Study I, Ek¡´gav¢ra Rasa (internal) and Mah¡m¡Àa Taila (external)
in Group I and áodhana therapy with M£rchhita TilaTaila in Group II were given. In study
II, Gorocan¡di Gu¶ik¡, A¿vagandh¡ Kv¡tha and Bal¡¿vagandh¡l¡kÀ¡di Taila were given
in Group I and in Group II áodhana therapy i.e. Vireicana and Yogabasti (Anuv¡sana &
Nir£ha) was administered. In Study III, conventional Paµcakarma therapy and áamana
therapy by Da¿am£la Kv¡tha and Candraprabh¡ Va¶¢ internally followed by Abhya´ga
and M¡tr¡basti with Da¿am£labal¡ Taila were tried. In study IV, Candraprabh¡ Va¶¢
along with Da¿am£la Kv¡tha orally, Da¿am£laBal¡ taila for local application along with
M¡tr¡basti and physiotherapy were given in Group I and in Group II, Virecana with
Era¸·a taila and Yogabasti (Anuv¡sana & Nir£ha) were given.
Pharmacological studies of extracts have been conducted on Sahacara and
Nirgu¸·¢ and established their anti-inflammatory and analgesic action. Biochemical
studies have been conducted on comparative analysis of B¤hat M¡Àa Taila and
physiochemical changes in M£rchhita TilaTaila and Bal¡¿vagandh¡l¡kÀ¡di Taila on
Abhya´ga. It is found to have significant difference in specific gravity, acid value and
saponification value.
All the studies showed promising and encouraging response. It is also observed that
the subjective and objective improvement of disease conditions was significant when
analyzed statistically. The studies also showed no adverse drug reaction as internal and
external use.
(Dr. G S. Lavekar)
New Delhi Director General
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CCRAS

CONTENTS
PAGE NO.
SUMMARY
Hindi
English
1. BACKGROUND
1.1. Ayurvedic Perspective
1.1.1 General Consideration about V¡tavy¡dhi
1.1.2 Nid¡na
1.1.3 Sampr¡pti of Pa´gu
1.1.4 Signs and symptoms of Pa´gu
1.1.5 Differential diagnosis
1.1.6 Prognosis
1.1.7 Principle of Treatment
1.2 Modern Perspective
1.2.1 Definition
1.2.2 Special techniques for neurological diagnosis
1.2.3 Transverse lesions of spinal cord
1.2.4 Clinical effects
1.2.5 Treatment

2. DRUG PROFILE
2.1 Ek¡´gav¢ra Rasa
2.2 Era¸·a Taila
2.3 Mah¡m¡Àa Taila
2.4 M£rchhita TilaTaila
2.5 Gorocan¡di Gu¶ik¡
2.6 A¿vagandh¡ Kv¡tha
2.7 Bal¡¿vagandh¡l¡kÀ¡di Taila
2.8 Da¿am£lalabal¡ Taila
2.9 Da¿am£lalabal¡ Kv¡tha
2.10 Candraprabh¡ Va¶¢
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3. PHARMACOLOGICAL STUDIES
3.1 Materials and Methods
3.1.1 Acute toxicity
3.1.2 Gross behaviour
3.1.3 Hypnotic potentiation
3.1.4 Effect on muscle tone and Bal¡nce (forced locomotor activity, FMA)
in mice
3.1.5 Effect on spontaneous motor activity (SMA) in mice
3.1.6 Antipsychotic activity
3.1.7 Anti-depressant activity
3.1.8 Anti-parkinsonism activity
3.1.9 Anti-convulsant activity
3.1.10 Analgesic activity
3.1.11 Anti-inflammatory activity
3.1.12 Immunosuppressant activity
3.1.13 Anti-microbial activity
3.1.14 Studies on isolated tissues

4. BIOCHEMICAL STUDIES
4.1 Comparative analytical studies on B¤hat M¡Àa Taila
4.1.1 Introduction
4.1.2 Materials and Methods
4.1.3 Results and Discussion
4.1.4 Conclusion
4.1.5 Physico-Chemical Changes in M£rchhita TilaTaila and
Bal¡¿vagandh¡l¡kÀ¡di Taila on Abhya´ga
4.1.6 Introduction
4.1.7 Materials and Methods
4.1.8 Results
4.1.9 Discussion

5. CLINICAL STUDY
3.1 Materials and Methods
3.2 Demographic Data
3.3 Result

6. DISCUSSION

7. CONCLUSION

APPENDICES
Bibliography
References
Case Record Form
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ABBREVIATIONS

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