Clinical Respiratory Medicine PDF
Preview Clinical Respiratory Medicine
1600JohnF.KennedyBlvd. Ste1800 Philadelphia,PA19103-2899 CLINICALRESPIRATORYMEDICINE,THIRDEDITION ISBN:978-0-323-04825-5 Copyright#2008,2004,1999byMosby,Inc.,anaffiliateofElsevierInc. Allrightsreserved.Nopartofthispublicationmaybereproducedortransmittedinanyformorbyany means,electronicormechanical,includingphotocopying,recording,oranyinformationstorageand retrievalsystem,withoutpermissioninwritingfromthepublisher.Permissionsmaybesoughtdirectly fromElsevier’sRightsDepartment:phone:(þ1)2152393804(US)or(þ44)1865843830(UK); fax:(þ44)1865853333;e-mail:[email protected] on-lineviatheElsevierwebsiteathttp://www.elsevier.com/permissions. Notice Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperience broadenourknowledge,changesinpractice,treatmentanddrugtherapymaybecomenecessary orappropriate.Readersareadvisedtocheckthemostcurrentinformationprovided(i)on proceduresfeaturedor(ii)bythemanufacturerofeachproducttobeadministered,toverifythe recommendeddoseorformula,themethodanddurationofadministration,andcontraindications. Itistheresponsibilityofthepractitioner,relyingontheirownexperienceandknowledgeofthe patient,tomakediagnoses,todeterminedosagesandthebesttreatmentforeachindividualpatient, andtotakeallappropriatesafetyprecautions.Tothefullestextentofthelaw,neitherthePublisher northeEditorsassumeanyliabilityforanyinjuryand/ordamagetopersonsorpropertyarisingout oforrelatedtoanyuseofthematerialcontainedinthisbook. ThePublisher LibraryofCongressCataloging-in-PublicationData Clinicalrespiratorymedicine/[editedby]RichardK.Albert,StephenG.Spiro, JamesR.Jett.—3rded. p.;cm. Includesbibliographicalreferencesandindex. ISBN-13:978-0-323-04825-5 1.Respiratoryorgans—Diseases. I.Albert,RichardK. II.Spiro,StephenG. III.Jett,JamesR. [DNLM:1.RespiratoryTractDiseases.2.LungDiseases.WF140C6412008] RC731.C652008 616.2—dc22 2007024654 SeniorAcquisitionsEditor:DoloresMeloni DevelopmentalEditor:AdrianneBrigido EditorialAssistant:KimberlyDePaul ProjectManager:BryanHayward DesignDirection:EllenZanolle PrintedinChina Lastdigitistheprintnumber:9 8 7 6 5 4 3 2 1 To our teachers Contributors RICHARD K. ALBERT, MD LUKAS BRANDER, MD Professor of Medicine, University of Colorado, DepartmentofIntensiveCareMedicine,UniversityHospital– Adjunct Professor of Engineering and Computer Science, Inselspital, Bern, Switzerland University of Denver, Chief, Department of Medicine, INVASIVE MECHANICAL VENTILATION Denver Health, Denver, Colorado ROY G. BROWER, MD CHEST PAIN Professor of Medicine, Medical Director, Medical Intensive MARK S. ALLEN, MD, FACS Care Unit, John Hopkins University School of Medicine, Professor of Surgery, Division of General Thoracic Surgery, Baltimore, Maryland Chair, Division of General Thoracic Surgery, Mayo Clinic, PULMONARY CIRCULATION Rochester, Minnesota JEREMY BROWN, MBBS, PhD, FRCP DIAGNOSTIC THORACIC SURGICAL PROCEDURES SeniorLecturer,CentreforRespiratoryResearch,Department CHARLES W. ATWOOD, JR, MD, FCCP, FAASM of Medicine, University College London, Consultant Associate Professor of Medicine, Director, Sleep Medicine Respiratory Physician, Department of Medicine, University Fellowship Program, Division of Pulmonary, Allergy, and College London Hospital, London, United Kingdom Critical Care Medicine, University of Pittsburgh, Medical PNEUMONIA IN THE NON-HIV IMMUNOCOMPROMISED HOST Director, Sleep Laboratory, Pulmonary and Critical Care Medicine,VAPittsburghHealthcareSystem,UniversityDrive TODD M. BULL, MD Division, Pittsburgh, Pennsylvania Associate Professor of Medicine, Division of Pulmonary CENTRAL SLEEP APNEA AND OTHER FORMS OF SLEEP- SciencesandCriticalCareMedicine,UniversityofColoradoat DISORDERED BREATHING Denver Health Sciences Center, Denver, Colorado MARIE CHRISTINE AUBRY, MD PULMONARY EMBOLISM ConsultantandAssociateProfessor,DepartmentofLaboratory PHILIPPE CAMUS, MD Medicine and Pathology, Mayo Clinic, Rochester, Minnesota Chairman, Division of Pulmonary and Intensive Care, MALIGNANT PLEURAL MESOTHELIOMA Hoˆpital du Bocage; Faculte´ de Me´decine, Universite´ ALAN F. BARKER, MD Bourgogne, Centre Hospitalier Universitaire de Dijon, Professor of Medicine, Division of Pulmonary and Critical Dijon, France Care, Department of Internal Medicine, Oregon Health and INFLAMMATORY BOWEL DISEASE; DRUGS AND THE LUNGS Science University, Portland, Oregon BRONCHIECTASIS CHRISTOPHER CARLSTEN, MD, MPH PETER J. BARNES, DM, DSc, FRCP, FMedSci Senior Fellow, Division of Pulmonary and Critical Care Medicine, Occupational and Environmental Medicine Professor of Thoracic Medicine, National Heart and Lung Program,DepartmentofMedicine,UniversityofWashington, Institute, Imperial College, London, United Kingdom b2-AGONISTS, ANTICHOLINERGICS, AND OTHER NONSTEROID DRUGS Seattle, Washington AIR POLLUTION THOMAS BENFIELD, MD, DMSci STEPHEN D. CASSIVI, MD, MSc, FRCSC, FACS ClinicalAssociateProfessor,DepartmentofSurgeryandInternal Medicine,UniversityofCopenhagen,Copenhagen,Denmark, AssociateProfessorofSurgery,DivisionofGeneralThoracic SeniorPhysician,DepartmentofInfectiousDiseases,Hvidovre Surgery,SurgicalDirectorofLungTransplantation, UniversityHospital,Hvidovre,Denmark WilliamJ.vonLiebigTransplantCenter,MayoClinic, Rochester,Minnesota NONINFECTIOUS CONDITIONS SURINDER S. BIRRING, MD, MRCP CHEST TUBE INSERTION AND MANAGEMENT; DIAGNOSTIC THORACIC SURGICAL PROCEDURES HonorarySeniorLecturer,Allergy,AsthmaandLungBiology, King’s College London, University of London, Consultant MOIRA CHAN-YEUNG, MB, FRCPC Respiratory Physician, Respiratory Medicine, King’s College Emeritus Professor, Department of Medicine, University of Hospital, London, United Kingdom British Columbia, Vancouver, British Columbia, Canada COUGH OCCUPATIONAL ASTHMA CHRIS T. BOLLIGER, MD, PhD Professor,DivisionofPulmonology,DepartmentofMedicine, JESSICAY. CHIA, MD Director, Respiratory Research Unit, University of Fellow in Pulmonary, Allergy, and Critical Care, Department Stellenbosch, Principle Medical Specialist, Division of of Medicine, Duke University Medical Center, Durham, Pulmonology, Department of Medicine, Tygerberg Academic North Carolina Hospital, Cape Town, Western Cape, South Africa PULMONARY COMPLICATIONS OF HEMATOPOIETIC STEM CELL PREOPERATIVE PULMONARY EVALUATION TRANSPLANTATION vii viii Contributors CHUNG-WAI CHOW, MD, PhD, FRCP(C) MARC DECRAMER, MD, PhD Assistant Professor, Department of Medicine, University of Professor,RespiratoryDivision,KatholiekeUniversiteit, Toronto, Toronto, Ontario, Canada DepartmentofPneumology,UZGasthuisberg,Leuven,Belgium HOST DEFENSES PULMONARY REHABILITATION CLAUDE DESCHAMPS, MD, FACS THOMAS V. COLBY, MD ProfessorofSurgery,DivisionofGeneralThoracicSurgery,Chair, ProfessorofPathology,MayoClinicArizona,Scottsdale,Arizona DepartmentofSurgery,MayoClinic,Rochester,Minnesota INFLAMMATORY BOWEL DISEASE CHEST TUBE INSERTION AND MANAGEMENT CHRISTOPHER D. COLDREN, PhD ANDREAS H. DIACON, MD, PhD Assistant Professor, Department of Medicine, University of Senior Lecturer, Division of Pulmonology, Department of Colorado at Denver and Health Sciences Center, Denver, Medicine, University of Stellenbosch, Part-Time Specialist, Colorado DivisionofPulmonology,DepartmentofMedicine,Tygerberg BASIC SCIENCE OF GENETICS APPLIED TO LUNG DISEASES Academic Hospital, Cape Town, Western Cape, South Africa JEAN-FRANC¸OIS CORDIER, MD PREOPERATIVE PULMONARY EVALUATION ProfessorofRespiratoryMedicine,DepartmentofRespiratory CHRISTOPHE DOOMS, MD Medicine, Reference Center for Orphan Pulmonary Diseases, DeputyHeadofClinic,RespiratoryOncologyUnit,University HoˆpitalLouisPradel,Universite´ ClaudeBernard,Lyon,France Hospital Gasthuisberg, Leuven, Belgium EOSINOPHILICLUNGDISEASE;ORGANIZINGPNEUMONIA PET IMAGING ULRICH COSTABEL, MD, FCCP RYAN H. DOUGHERTY, MD Professor of Medicine, Medicine Faculty, University of ClinicalFellow,Medicine–Pulmonary&CriticalCare, Duisburg-Essen, Chief, Pheumology and Allergy, UniversityofCalifornia,SanFrancisco,SanFrancisco,California Ruhrlandklinic, Essen, Germany ASTHMA: CELL BIOLOGY IDIOPATHICPULMONARYFIBROSISANDOTHERIDIOPATHICINTERSTITIAL NEIL J. DOUGLAS, MD, FRCP, FRCPE PNEUMONIAS Professor of Respiratory & Sleep Medicine, Department of VINCENT COTTIN, MD, PhD Respiratory Medicine, University of Edinburgh, Director, ProfessorofRespiratoryMedicine,Universite´ ClaudeBernard, Scottish National Sleep Centre, Edinburgh, United Kingdom DepartmentofRespiratoryMedicineReferenceCenterfor OBSTRUCTIVE SLEEP APNEA OrphanPulmonaryDisease,HoˆpitalLouisPradel,Lyon,France GREGORY P. DOWNEY, MD, FRCP(C) EOSINOPHILIC LUNG DISEASE; ORGANIZING PNEUMONIA Professor,MedicineandImmunology,UniversityofColorado, GERARD J. CRINER, MD ExecutiveVicePresident,AcademicAffairs,Professor, Professor of Medicine, Director of Pulmonary & Critical Care DepartmentofMedicine,Pediatrics,andImmunology,National Medicine, Temple University School of Medicine, Temple JewishMedicalandResearchCenter,Denver,Colorado University Hospital, Pulmonary & Critical Care Medicine, HOST DEFENSES Temple University, Director, Temple Lung Center, Temple SCOTT E. EVANS, MD University Hospital, Philadelphia, Pennsylvania Assistant Professor, Department of Pulmonary Medicine, OXYGEN THERAPY University of Texas-M.D. Anderson Cancer Center, Houston, BRUCE H. CULVER, MD Texas Associate Professor of Medicine, Division of Pulmonary and PULMONARY FUNCTION TESTING Critical Care, University of Washington School of Medicine, TIMOTHY W. EVANS, BSc, MD, PhD, DSc, FRCP, FRCA, Seattle, Washington FMedSci RESPIRATORY MECHANICS; GAS EXCHANGE IN THE LUNG; PULMONARY Professor of Intensive Care Medicine, Critical Care Unit, CIRCULATION;ACID–BASEBALANCEANDCONTROLOFVENTILATION; Imperial College School of Medicine, Consultant in Intensive PULMONARYFUNCTIONTESTING Care and Thoracic Medicine, Intensive Care Unit CHARLES L. DALEY, MD Royal Brompton Hospital, London, United Kingdom ProfessorofMedicine,DivisionofPulmonaryandCriticalCare PULMONARY HYPERTENSION Medicine, University of Colorado Health Sciences Center, JEAN-WILLIAM FITTING, MD Head, Division of Mycobacterial and Respiratory Infections, Associate Professor, Service de Pneumologie, Centre Department of Medicine, National Jewish Medical and Hospitalier Universitaire Vaudois, Lausanne, Switzerland Research Center, Denver, Colorado DISEASES OF THE THORACIC CAGE AND RESPIRATORY MUSCLES TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIAL INFECTIONS RODNEY J. FOLZ, MD, PhD HELEN E. DAVIES, MB, BS, MRCP ProfessorandChief,DivisionofPulmonary,CriticalCare,and ResearchFellow,OxfordCentreforRespiratoryMedicineand Sleep Disorders Medicine, University of Louisville Health University of Oxford, Churchill Hospital, Oxford, United Sciences Center, Louisville, Kentucky Kingdom PULMONARY COMPLICATIONS OF HEMATOPOIETIC STEM CELL PLEURAL EFFUSION, EMPYEMA, AND PNEUMOTHORAX TRANSPLANTATION Contributors ix EDWARD R. GARRITY, JR, MD, MBA NICHOLAS S. HILL, MD ProfessorofMedicine,SectionofPulmonaryandCriticalCare, Professor of Medicine, Chief, Division of Pulmonary, Critical Vice-Chair, Clinical Operations, Department of Medicine, Care, and Sleep Medicine, Tufts-New England Medical University of Chicago, Chicago, Illinois Center, Tufts University School of Medicine, Boston, LUNG TRANSPLANTATION Massachusetts BRIAN K. GEHLBACH, MD NONINVASIVE MECHANICAL VENTILATION Assistant Professor of Medicine, Section of Pulmonary and STELLA E. HINES, MD, FACP Critical Care, University of Chicago, Chicago, Illinois University of Colorado Health Sciences Center, Denver, OBESITY Colorado MARK W. GERACI, MD EXTRINSIC ALLERGIC ALVEOLITIS Professor of Medicine, Head, Division of Pulmonary Sciences RICHARD HUBBARD, MSc, DM and Critical Care Medicine, Department of Medicine, Professor of Respiratory Epidemiology, Epidemiology, and University of Colorado Health Sciences Center, Denver, Public Health, University of Nottingham, Consultant Chest Colorado Physician, Respiratory Medicine, Nottingham City Hospital, BASIC SCIENCE OF GENETICS APPLIED TO LUNG DISEASES Nottingham, United Kingdom RIK GOSSELINK, PT, PhD ASTHMA: EPIDEMIOLOGY AND RISK FACTORS Professor, Department of Rehabilitation Sciences, Katholieke GE´RARD J. HUCHON, MD Universiteit Leuven, Department of Pneumology, UZ Head of Service de Pneumologie et Re´animation, Hoˆpital de Gasthuisberg, Leuven, Belgium l’Hoˆtel-Dieu, Professor of Respiratory Medicine, Universite´ PULMONARY REHABILITATION Rene´ Descartes, Paris, France E. BRIGITTE GOTTSCHALL, MD, MSPH BACTERIAL PNEUMONIA; NONBACTERIAL PNEUMONIA AssistantProfessor,DivisionofPulmonaryandCriticalCare LEONARD D. HUDSON, MD Medicine,DepartmentofMedicine,DepartmentofPreventive Professor, Division of Pulmonary and Critical Care Medicine, MedicineandBiometrics,UniversityofColoradoatDenverand Department of Medicine, Seattle, Washington HealthSciencesCenter,Denver,Colorado ACUTE RESPIRATORY DISTRESS SYNDROME ASBESTOSIS JOHN R. HURST, PhD, MRCP MICHAEL P. GRUBER, MD Senior Lecturer, Academic Unit of Respiratory Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Royal Free & University College Medical School, University University of Colorado Health Sciences Center, Denver, College London, Honorary Consultant in Respiratory and Colorado Acute Medicine, Royal Free Hampstead NHS Trust, London, PULMONARY EMBOLISM United Kingdom MANAGEMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE J.C. GRUTTERS, MD, PhD PULMONARY DISEASE Heart Lung Center Utrecht, Department of Pulmonology, MICHAEL C. IANNUZZI, MD, MBA St. Antonius Hospital, Niewegein, the Netherlands Division of Pulmonary, Critical Care, and Sleep Medicine, CONNECTIVE TISSUE DISORDERS Department of Medicine, Mount Sinai School of Medicine, JESSE B. HALL, MD New York, New York Professor of Medicine, Anesthesia, and Critical Care, Section SARCOIDOSIS Chief, Pulmonary and Critical Care, University of Chicago, JAMES R. JETT, MD Chicago, Illinois Professor of Medicine, Mayo Clinic College of Medicine, OBESITY Consultant in Pulmonary Medicine and Medical Oncology, DAVID M. HANSELL, MD, FRCP, FRCR Rochester, Minnesota Professor of Thoracic Imaging, Department of Radiology, LUNG TUMORS; MALIGNANT PLEURAL MESOTHELIOMA Royal Brompton Hospital, London, United Kingdom JOEL D. KAUFMAN, MD, MPH IMAGING TECHNIQUES Professor, Department of Medicine, Department of INDERJIT K. HANSRA, MD, MS Environmental and Occupational Health Sciences, Clinical Associate, Department of Pulmonary and Critical Department of Epidemiology, University of Washington, Care, Tufts University, Boston, Massachusetts Seattle, Washington NONINVASIVE MECHANICAL VENTILATION AIR POLLUTION FELIX J.F. HERTH, MD, PhD, FCCP VICTOR KIM, MD Professor of Medicine, Pneumology and Critical Care AssistantProfessorofMedicine,DivisionofPulmonaryand Medicine,Thoraxklinik,UniversityofHeidelberg,Heidelberg, CriticalCareMedicine,DepartmentofInternalMedicine, Germany TempleUniversitySchoolofMedicine,Philadelphia, TRANSBRONCHIAL AND ESOPHAGEAL ULTRASOUND-GUIDED BIOPSY OF Pennsylvania THE MEDIASTINUM OXYGEN THERAPY x Contributors COENRAAD F.N. KOEGELENBERG, MBChB, FCP(SA), JEAN-LUC MALO, MD MRCP(UK) Professor, Department of Medicine, Faculte´ de Me´decine, Senior Specialist, Division of Pulmonology, Department of Universite´ deMontre´al,Chestphysician,Medicine,Hoˆpitaldu Medicine, University of Stellenbosch, Senior Specialist, Sacre´.-Coeur de Montre´al, Montre´al, Que´bec, Canada DivisionofPulmonology,DepartmentofMedicine,Tygerberg OCCUPATIONAL ASTHMA Academic Hospital, Cape Town, Western Cape, South Africa RYAN M. MCGHAN, MD, MSPH PREOPERATIVE PULMONARY EVALUATION Instructor in Medicine, Division of Pulmonary Sciences and JOHN W. KREIT, MD CriticalCare,DepartmentofMedicine,UniversityofColorado AssociateProfessorofMedicine,DivisionofPulmonary,Allergy, at Denver and Health Sciences Center, Denver, Colorado andCriticalCareMedicine,UniversityofPittsburghSchoolof CORTICOSTEROIDS Medicine,Pittsburgh,Pennsylvania SARAH MCKINLEY, MD HEMOPTYSIS University of Colorado Health Sciences Center, Denver, MICHAEL J. KROWKA, MD Colorado Professor of Medicine, Pulmonary and Critical Care, Mayo BASIC SCIENCE OF GENETICS APPLIED TO LUNG DISEASES Clinic, Rochester, Minnesota DAVID E. MIDTHUN, MD HEPATIC AND BILIARY DISEASE Associate Professor of Medicine, Pulmonary and Critical Care DANIEL LANGER, MSc Medicine, Mayo Clinic College of Medicine, Rochester, Department of Rehabilitation Sciences, Katholieke Minnesota Universiteit Leuven, Respiratory Division, UZ Gasthuisberg, LUNG TUMORS Leuven, Belgium ROBERT F. MILLER, MB, BS, FRCP PULMONARY REHABILITATION Professor, Centre for Sexual Health and HIV Research, STEPHEN E. LAPINSKY, MB BCh, MSc, FRCPC University College London, Honorary Consultant, University Associate Professor of Medicine, Department of Medicine, College London Hospitals, London, United Kingdom University of Toronto, Site Director, Intensive Care Unit, PULMONARY INFECTIONS Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada THEO J. MORAES, MD, FRCPC PREGNANCY Fellow, Division of Respirology, The Hospital for Sick Children, Toronto, Ontario, Canada STEPHEN C. LAZARUS, MD HOST DEFENSES ProfessorofMedicine,Director,FellowshipPrograminPulmonary JEFFREY L. MYERS, MD &CriticalCareMedicine,AssociateDirector,AdultPulmonary A. James French Professor of Diagnostic Pathology, Laboratory,SeniorInvestigator,CardiovascularResearchInstitute, Department of Pathology, University of Michigan Medical DivisionofPulmonaryandCriticalCareMedicine,Universityof School, Director, Division of Anatomic Pathology, California,SanFrancisco,SanFrancisco,California Department of Pathology, University of Michigan Health ASTHMA: CELL BIOLOGY System, Ann Arbor, Michigan Y.C. GARY LEE, MBChB, PhD, FRACP, FCCP LAM AND OTHER DIFFUSE LUNG DISEASES Consultant Chest Physician and Senior Lecturer, Oxford MARGARET J. NEFF, MD Centre for Respiratory Medicine, University of Oxford, Associate Professor of Medicine, Division of Pulmonary and Churchill Hospital, Oxford, United Kingdom CriticalCareMedicine,DepartmentofMedicine,Universityof PLEURAL EFFUSION, EMPYEMA, AND PNEUMOTHORAX Washington, Seattle, Washington ACUTE RESPIRATORY DISTRESS SYNDROME SYLVIE LEROY, MD LEE S. NEWMAN, MD, MA Medical Doctor - Practitioner, Department of Pulmonology, Professor,DepartmentofPreventiveMedicineandBiometrics, Hospital Calmette, Lille, France Department of Medicine, University of Colorado at Denver SILICOSIS AND COAL WORKER’S PNEUMOCONIOSIS and Health Sciences Center, Denver, Colorado MARC C.I. LIPMAN, MD, FRCP ASBESTOSIS; TOXIC INHALATIONAL LUNG INJURY Cunsultant Physician, Department of Respiratory & HIV ERIC J. OLSON, MD Medicine, Royal Free Hospital, London, United Kingdom Associate Professor of Medicine, Mayo Clinic College of PULMONARY INFECTIONS Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota WILLIAM MACNEE, MBChB, MD, FRCP(Glas), FRCP(Edin) LAM AND OTHER DIFFUSE LUNG DISEASES Professor of Respiratory & Environmental Medicine, MRC SIMON P.G. PADLEY, BSc, MB.BS, FRCP, FRCR Centre for Inflammation Research, University of Edinburgh, Honorary Senior Lecturer, Imperial College School of Honorary Consultant Physicians, Respiratory Medicine, Royal Medicine, Imperial College, Consultant, Radiology InfirmaryofEdinburgh,Edinburgh,Scotland,UnitedKingdom Department, Chelsea and Westminster Hospital, Royal CHRONIC OBSTRUCTIVE PULMONARY DISEASE: EPIDEMIOLOGY, Brompton Hospital, London, United Kingdom PHYSIOLOGY, AND CLINICAL EVALUATION IMAGING TECHNIQUES Contributors xi MARTYN R. PARTRIDGE, MD, FRCP GLENIS K. SCADDING, MA, MD, MRCP Professor of Respiratory Medicine, National Heart and Lung Honorary Senior Lecturer, Department of Immunology, Institute Division, Charing Cross Hospital, Honorary University College, Consultant Allergist/Rhinologist, Consultant Physician, Department of Respiratory Medicine, Department of Allergy/Medical Rhinology, Royal National Imperial College London, London, United Kingdom Throat, Nose, and Ear Hospital, London, United Kingdom ASTHMA: CLINICAL FEATURES, DIAGNOSIS, AND TREATMENT RHINITIS AND SINUSITIS IAN D. PAVORD, DM, FRCP PAUL D. SCANLON, MD Honorary Professor of Medicine, Department of Respiratory ProfessorofMedicine,DivisionofPulmonaryandCriticalCare Medicine, Allergy and Thoracic Surgery, Glenfield Hospital, Medicine, Mayo Clinic, Rochester, Minnesota Leicester, United Kingdom PULMONARY FUNCTION TESTING COUGH REBECCA E. SCHANE, MD JOANNA C. PORTER, MA, BM, BCh, FRCP, PhD Clinical Research Fellow, General and Internal Medicine, HonorarySeniorLecturerinRespiratoryMedicine,Laboratory Division of Pulmonary/Critical Care Medicine, Center for forMolecularCellBiology,UniversityCollegeLondon, Tobacco Control Research and Education, General and HonoraryConsultantinRespiratoryandGeneralInternal Internal Medicine, Cardiovascular Research Institute, Medicine,DepartmentofRespiratoryMedicine,University University of California, San Francisco, San Francisco, CollegeLondonHospitalsNHSTrust,ClinicalResearchFellow, California MRCLaboratoryforMolecularCellBiology,UniversityCollege CHRONIC OBSTRUCTIVE PULMONARY DISEASE: MANAGEMENT London,London,UnitedKingdom OF CHRONIC DISEASE DYSPNEA MARVIN I. SCHWARZ, MD ANTOINE RABBAT, MD University of Colorado Health Sciences Center, James C. Praticien Hospitalier, Assistance Publique Hoˆpitaux de Paris, Campbell Professor of Pulmonary Medicine, Division of Pneumologie and Re´animation, Hoˆtel-Dieu, Paris, France Pulmonary Sciences and Critical Care Medicine, University BACTERIAL PNEUMONIA; NONBACTERIAL PNEUMONIA of Colorado, Denver, Colorado FELIX RATJEN, MD, PhD, FRCPC PULMONARY VASCULITIS AND HEMORRHAGE Professor, Department of Pediatrics, University of Toronto, FABIAN SEBASTIAN, MD, FRCR Division Head, Department of Respiratory Medicine, The Radiology Registrar, Department of Radiology, University Hospital for Sick Children, Toronto, Ontario, Canada College Hospital, London, United Kingdom CYSTIC FIBROSIS PERCUTANEOUS BIOPSY PROCEDURES ANNA K. REED, MB, ChB, MRCP JONATHAN E. SEVRANSKY, MD ClinicalResearchFellowinPulmonaryVascularDisease,Unit Assistant Professor of Medicine, Medical Director, JHMBC of Critical Care, Imperial College School of Medicine and ICU, Division of Pulmonary and Critical Care Medicine, National Heart Lung Institute, Royal Brompton Hospital, Johns Hopkins Asthma and Allergy Center, Baltimore, London, United Kingdom Maryland PULMONARY HYPERTENSION PULMONARY CIRCULATION MELISSA L. ROSADO-DE-CHRISTENSON, MD, FACR LORI SHAH, MD AdjunctProfessorofRadiology,DepartmentofRadiologyand Assistant Professor of Medicine, Associate Director, Nuclear Medicine, Uniformed Services University of the Lung Transplantation Program, Department of Medicine, Health Sciences, Bethesda, Maryland Mount Sinai School of Medicine, New York, New York DISORDERS OF THE MEDIASTINUM SARCOIDOSIS CECILE S. ROSE, MD, MPH PENNY SHAW, MBBS, DMRD, MRCP, FRCR AssociateProfessorofMedicine,UniversityofColoradoHealth SciencesCenter,Director,OccupationalLungDiseaseClinic, Consultant Radiologist with Thoracic Subspecialty Interest, NationalJewishMedicalandResearchCenter,Denver,Colorado Department of Radiology, University College London Hospitals NHS Trust, London, United Kingdom EXTRINSIC ALLERGIC ALVEOLITIS PERCUTANEOUS BIOPSY PROCEDURES CHARIS ROUSSOS, MD, PhD DAVID W. SHIMABUKURO, MDCM Professor and Chairman, Pulmonary and Critical Care, Assistant Professor, Department of Anesthesia and University of Athens, Medical School, Athens, Greece Perioperative Care, University of California, San Francisco, PHYSIOLOGY AND TESTING OF RESPIRATORY MUSCLES San Francisco, California LUIS G. RUIZ, MD AIRWAY MANAGEMENT Fellow, Section of Pulmomary and Critical Care Department KATHY E. SIETSEMA, MD of Medicine, University of Chicago, Chicago, Illinois ProfessorofMedicine,DepartmentofMedicine,DavidGeffen LUNG TRANSPLANTATION School of Medicine at UCLA, Los Angeles, California, Chief, JAY H. RYU, MD Division of Respiratory & Critical Care Physiology and ProfessorofMedicine,DivisionofPulmonaryandCriticalCare Medicine, Department of Medicine, Harbor-UCLA Medical Medicine,MayoClinicCollegeofMedicine,Rochester,Minnesota Center, Torrance, California LAM AND OTHER DIFFUSE LUNG DISEASES EXERCISE TESTING xii Contributors ANITA K. SIMONDS, MD THIERRY TROOSTERS, PhD Consultant in Respiratory Medicine, Royal Brompton Professor Respiratory Division, Katholieke Universiteit Hospital, London, United Kingdon Leuven, Department of Pneumology, UZ Gasthuisberg, SCOLIOSIS AND KYPHOSCOLIOSIS Leuven, Belgium ARTHUR S. SLUTSKY, MD, PhD PULMONARY REHABILITATION Professor, Department of Medicine, Surgery and ELIZABETH TULLIS, MD, FRCPC Biomedical Engineering, University of Toronto, AssociateProfessor, DepartmentofRespirology,Universityof Vice President, Research, St. Michael’s Hospital, Toronto, Toronto, Medical Director, Adult Cystic Fibrosis Clinic, Ontario, Canada Division Head, Department of Respirology, St. Michael’s INVASIVE MECHANICAL VENTILATION Hospital, Toronto, Ontario, Canada STEPHEN G. SPIRO, MD, FRCP CYSTIC FIBROSIS Professor of Respiratory Medicine, Consultant Physician, ANILVACHANI, MD General and Thoracic Medicine, University College Assistant Professor of Medicine, Department of Medicine, London Hospitals NHS Trust, London, United Kingdom University of Pennsylvania, Philadelphia, Pennsylvania THORACENTESIS AND CLOSED PLEURAL BIOPSY BRONCHOSCOPY DANIEL H. STERMAN, MD MAURICIO VALENCIA, MD Associate Professor of Medicine, Department of Medicine, University of Pennsylvania, Director of Interventional Senior Researcher, Respiratory Intensive Care Medicine, Pulmonology,Pulmonary,Allergy, andCriticalCareDivision, Hospital Clinic de Barcelona, Barcelona, Spain University of Pennsylvania School of Medicine, Philadelphia, NOSOCOMIAL PNEUMONIA Pennsylvania J.M.M. VAN DEN BOSCH, MD BRONCHOSCOPY Heart Lung Center Utrecht, Department of Pulmonology, KAYLAN E. STINSON, MSPH St. Antonius Hospital, Niewegein, The Netherlands Professional Research Assistant, Department of Preventive CONNECTIVE TISSUE DISORDERS Medicine and Biometrics, University of Colorado at Denver JOHAN VANSTEENKISTE, MD, PhD and Health Science Center, Denver, Colorado Associate Professor, Internal Medicine, Catholic TOXIC INHALATIONAL LUNG INJURY University, Head of Clinic, Respiratory Oncology Unit DIANE C. STROLLO, MD, FACR (Pulmonology), University Hospital Gasthuisberg, Leuven, Belgium Associate Professor, Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania PET IMAGING DISORDERS OF THE MEDIASTINUM THEODOROS VASSILAKOPOULOS, MD Assistant Professor, Critical Care Department, PATRICK J. STROLLO, JR, MD, FCCP, FAASM University of Athens, Medical School, Associate Professor of Medicine, Medical Director, UPMC Athens, Greece Sleep Medicine Center, Division of Pulmonary, Allergy, and PHYSIOLOGY AND TESTING OF RESPIRATORY MUSCLES Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania BENOIT WALLAERT, MD CENTRAL SLEEP APNEA AND OTHER FORMS OF SLEEP-DISORDERED Professor of Medicine, University Lille, Head, Clinique des Maladies Respiratoirses, Hospital Calmette, Lille, BREATHING France DARRYLY. SUE, MD SILICOSIS AND COAL WORKER’S PNEUMOCONIOSIS Professor of Clinical Medicine, Department of Medicine, JADWIGA A. WEDZICHA, MD, FRCP David Geffen School of Medicine at UCLA, Los Angeles, Professor of Respiratory Medicine, Academic Unit of California,AssociateChairandProgramDirector,Department Respiratory Medicine, Royal Free & University College of Medicine, Harbor-UCLA Medical Center, Torrance, Medical School, University College London, Royal Free California Hampstead NHS Trust, London, United Kingdom EXERCISE TESTING MANAGEMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE ALVIN S. TEIRSTEIN, MD PULMONARY DISEASE Professor of Medicine, Department of Medicine, ATHOLWELLS, MBChB, FRACP, MD Mout Sinai School of Medicine, New York, New York Consultant Physician, Royal Brompton Hospital, London, SARCOIDOSIS United Kingdom ANTONI TORRES, MD APPROACH TO DIAGNOSIS OF DIFFUSE LUNG DISEASE Professor, Facultat de Medicina, Universitat de Barcelona, DOROTHYA. WHITE, MD Chief, Department of Pulmonology, Hospital Clinic, Assistant Professor of Medicine, Memorial Sloan-Kettering Barcelona, Spain Cancer Center, New York, New York NOSOCOMIAL PNEUMONIA DRUGS AND THE LUNGS Contributors xiii JEANINE P. WIENER-KRONISH, MD STEPHEN J. WORT, MA (OXON), MBBS, MRCP, PhD Professor of Anesthesia and Medicine, Department of ClinicalSeniorLecturer,PulmonaryHypertensionandCritical Anesthesia and Perioperative Care, University of California, Care, Imperial College, Consultant, Pulmonary Hypertension San Francisco, San Francisco, California and Critical Care, Royal Brompton and Harefield NHS Trust, AIRWAY MANAGEMENT London, United Kingdom MARK A. WOODHEAD, MBBS, BSc, DM, FRCP PULMONARY HYPERTENSION ConsultantinGeneralandRespiratoryMedicine,Department JOKKE WYNANTS, MD of Respiratory Medicine, Manchester Royal Infirmary, Resident, Respiratory Oncology Unit (Pulmonology), Honorary Senior Lecturer, Faculty of Medical and Human University Hospital Gasthuisberg, Leuven, Belgium Sciences, University of Manchester, Manchester, United PET IMAGING Kingdom AN APPROACH TO THE DIAGNOSIS OF PULMONARY INFECTION PRESCOTT G. WOODRUFF, MD, MPH Assistant Professor of Medicine in Residence, Department of Medicine, Division of Pulmonary Critical Care Medicine, University of California, San Francisco, California CHRONICOBSTRUCTIVEPULMONARYDISEASE:MANAGEMENT OFCHRONICDISEASE
The list of books you might like
