Maurice Barry Clinical Practice in Rheumatology Foreword by Professor Michael Doherty , Springer Maurice Barry, MB, FRCPI Consultant Rheumatologist James Connolly Memorial Hospital Blanchardstown, Dublin, Ireland British Library Cataloguing in Publication Data Barry, Maurice Clinic al practice in rheumatology 1. Rheumatology 1. Title 616.7'23 ISBN 978-1-85233-719-3 ISBN 978-0-85729-430-2 (eBook) DOI 10.1007/978-0-85729-430-2 American Library of Congress Cataloging-in-Publication Data A Catalog record for this book is available from the Library of Congress ISBN 978-1-85233-719-3 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency. Enquiries concerning repro duction outside those terms should be sent to the publishers. © Springer-Verlag London 2003 Originally published by Springer-Verlag London Limited in 2003 2nd printing 2004 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literat ure. Typeset by Florence Production Ltd, Stoodleigh, Devon, England 28/3830-54321 Printed on acid-free paper SPIN 10993811 Dedication To the patients and staffofthe Department ofRheumatology, Blanchardstown Hospital, and to Rosie, Rory, Kate and Stevie. Preface Rheumatology is predominantly aclinic-based speciality. The medical staff in the clinic often includes doctors in their early postgraduate years who rotate through the specialtyeveryfew months.Theyusuallyarrive knowing less about the basics of rheumatology than other specialties, but rapidly need to learn what to ask or do next with the patient sitting in front of them. The book is aimed at this group. It will also be ofbenefit to trainees in general (internal) medicineandgeneralorfamilypractice,and to medical students, rheumatology nurse specialists and allied health professionals. A further aim in writing this book is to reduce the time busy departments need to spend inducting new medical staffevery few months. Wehavetriedtoincludethecurricularrequirementinrheumatologylikely to be needed for Parts Iand II ofthe Membership in Medicine. Any sugges tionsfor improvementsthatmightbemade infuture editionsarewelcome. Maurice Barry ConsultantRheumatologist, JamesConnollyMemorial Hospital, Dublin Acknowledgements The initial draft of some sections was contributed to by junior doctors attached to the team. They include Jillian Drury, Mike McWeeney, Liz Maxwell, Ferga Gleeson and Ai Shiang Bong. Killian O'Rourke and SA Ramakrishnan wrote a number of sections. I thank them for their major contribution to what began as guidelines for use in our department. Thanks to Sara Tubb for typing the manuscript and to Ray Lohan and Oliver O'Flanagan of the Media Services Department at the Royal College of Surgeons in Ireland for the clinical photographs. Thanks also to those patients who allowed themselves be photographed. The support of Brenda Dooley of Pharmacia and Melissa Morton and Eva Senior ofSpringer-Verlag London is much appreciated. v Theseillustrationsshowthreewomenwithlongstandingsero-positiverheumatoidarthritis.They illustratetherealityofrecentyearsformanywithrheumatoidarthritis,particularlythosetreated earlyandappropriately.Notetheabsenceofulnardeviation,swan-neck,Boutonniere,Zthumb orotherdeformities(permissionsreceived). vi Foreword Locomotor assessment is a required competance ofany doctor due to the highprevalenceofmusculoskeletalconditions.Thespectrumofthesecondi tionsrangesfrom relativelyminorself-limitingmechanicalstrainstocomplex life-threatening multisystem disease.This wide range ofconditions and the anatomical complexity ofthe system make clinical assessment ofa patient with musculoskeletal symptoms a daunting challenge for many trainees. Oftenthechallenge is madegreaterbecauseoflow prioritisation ofmuscu loskeletal clinical skills teaching in some Medical Schools. Thisshorthandbook,therefore,isverywelcome.Written byMauriceBarry aConsultant Rheumatologist in Dublin, it briefly summarises the key prac tical points relating to the assessment, investigation and management of patientswith musculoskeletal disease. Itsuncluttered bullet-pointed format and clarity of style make it a rapid and easy source of clinically relevant information. Apart from system-specific detail there is an appropriate emphasis on the wider holistic assessment ofthe individual with musculo skeletal pain. This first Edition is fully up-to-date and should prove invaluable to its target audience of Senior House Officers and Specialist Registrars in Rheumatology and General Internal Medicine. It is likely to become the standard Departmental Manual for many UK Rheumatology Units. The book should also prove useful for a wider range of doctors in Primary and Secondary Care and for Allied Health Professionals who work in a Rheumatology MultidisciplinaryTeam. Michael Doherty ProfessorofRheumatology Nottingham UniversityMedicalSchool. vii Contents 1 History Taking . 1 New Patients . 1 Extra-articular Symptom Review (Dr K O'Rourke) . 2 2 Locomotor Examination (Dr S A Ramakrishnan) . 3 Range ofMovement (ROM) . 6 3 Common New Presentations . 13 4 Clinic Checklist 17 5 Common Operational Issues . 18 6 Imaging Guidelines . 19 When to Order Plain Radiographs . 19 7 Indices, Instruments, Questionnaires . 21 8 How to Manage Patients . 23 General Guidelines . 23 How Often Should Patients be Reviewed? . 23 Prescriptions . 23 Who to Admit . 23 Blood Forms . 24 When to Seek Advice . 24 The Power ofReassurance . 24 Psychosocial Aspects ofRheumatology . 25 Complementary Treatments . 26 Analgesics . 27 Opioid Analgesics . 27 Non-steroidal Anti-inflammatory Drugs (NSAIDs) . 29 Disease-modifying Drugs (DMARDs) . 30 Methotrexate . 30 Sulfasalazine . 31 ix x Contents Hydroxychloroquine (Plaquenil) 32 Azathioprine 32 Gold (Myocrisin) 33 Ciclosporin (Cyclosporin) 34 Cyclophosphamide . . . . . . . . . . . . . . . . . . . . . . . . . .. 35 Newer Agents in Inflammatory Arthritis 36 Leflunomide (Arava) . . . . . . . . . . . . . . . . . . . . . . . . .. 36 Biological Agents .. . . . . . . . . . . . . . . . . . . . . . . . . .. 36 Joint Injections 38 Role ofHealth Professionals 39 Rheumatology Nurse Specialist .. . . . . . . . . . . . . . . .. 39 Physiotherapist 40 Occupational Therapist 41 Rheumatological Disorders 9 Soft Tissue Problems 42 Fibromyalgia Syndrome 42 Neck Pain/Low Back Pain. . . . . . . . . . . . . . . . . . . . . . .. 44 Shoulder Pain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 48 Carpal Tunnel Syndrome 49 Epicondylitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 50 Bursitis (Dr K O'Rourke) 51 De Quervain's Tenosynovitis. . . . . . . . . . . . . . . . . . . . .. 52 Achilles Tendonitis. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 52 Plantar Fasciitis 53 Benign Hypermobility Syndrome. . . . . . . . . . . . . . . . . .. 53 10 Osteoarthritis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 56 Diffuse Idiopathic Skeletal Hyperostosis (DISH) . . . . . . .. 57 11 Rheumatoid Arthritis 58 12 Seronegative Spondylarthropathy . . . . . . . . . . . . . . . . .. 63 Psoriatic Arthritis (Dr KO'Rourke) 64 Ankylosing Spondylitis . . . . . . . . . . . . . . . . . . . . . . . . .. 64 Reactive Arthritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66 Arthritis Associated with Inflammatory Bowel Disease ... 67 Behc;:et's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 68 13 Connective Tissue Diseases (CTD) 69 Autoantibodies: A Synopsis . . . . . . . . . . . . . . . . . . . . . . . 69 Raynaud's Phenomenon 71 Systemic Lupus Erythematosus (Dr KO'Rourke) 72 Contents xi Anti-phospholipid Syndrome (APS) (Dr KO'Rourke) . . .. 75 Mixed Connective Tissue Disease (MCTD) . . . . . . . . . . . . 75 Sjogren's Syndrome 76 Scleroderma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 Polymyositis/Dermatomyositis 78 Differential Diagnosis ofMuscle Pain and or Weakness . .. 79 Vasculitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 14 Infection and Arthritis (Dr S A Ramakrishnan) . . . . . .. 83 15 Pregnancy and Rheumatic Diseases 87 16 Inheritance and Rheumatic Diseases 89 17 Crystal Arthritis 90 Gout 90 Pseudogout 92 18 Polymyalgia Rheumatica (PMR) . . . . .. 93 19 Osteoporosis 95 Acute Vertebral Fracture . . . . . . . . . . . . . . . . . . . . . . . . . 97 20 Paget's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 98 21 Osteomalacia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 100 22 Uncommon Rheumatological Conditions (Dr S A Ramakrishnan) . . . . . . . . . . . . . . . . . . . . . . . . .. 102 Reflex Sympathetic Dystrophy (RSD) . . . . . . . . . . . . . . .. 102 Relapsing Polychondritis . . . . . . . . . . . . . . . . . . . . . . . .. 102 Pigmented Villonodular Synovitis (PVNS) 103 Rheumatic Fever. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 103 Adult Onset Still's Disease (AOSD) 104 Sarcoidosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 104 Further Reading 105 Useful Websites 105 Index 107 Note to the Reader A couple of points are worth emphasising: • Although we treat some interesting and complex diseases, chronic musculoskeletal pain is frequently either caused by or exacerbated by psychosocial distress. Ifyou learn to distinguish the often subtle differences between organic and non-organic causes of pain and can deal capably and sensitively with both, you will enjoy the specialty. • Be positive with the patient. Making people feel reassured (usually appropriate irrespective of diagnosis) and engendering a positive attitude (always appropriate) can be as potent as any drug and should be appreciated for their true worth. Before starting the rheumatology rotation you should revise musculo skeletal anatomy; undergraduate orthopaedic and immunology notes should also be revisited. xiii