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Clinical Pharmacology Made Incredibly Easy!. PDF

450 Pages·2008·7.763 MB·English
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938900FM.qxd 08/26/2008 18:11 Page i Clinical Pharmacology yy bbll ddii d eee a mrr cc nn II !! yy ss ® aa EE 938900FM.qxd 08/26/2008 18:11 Page ii 938900FM.qxd 08/26/2008 18:11 Page iii Clinical Pharmacology yy ll bb dii d ee d e a mrr c c n n I I !! yy ss ® a a E E 938900FM.qxd 08/26/2008 18:11 Page iv Staff The clinical treatments described and recommended in this publication are based on research and consultation with nurs- ing, medical, and legal authorities. To the best of our knowl- Executive Publisher edge, these procedures reflect currently accepted practice. Judith A. Schilling McCann, RN, MSN Nevertheless, they can’t be considered absolute and universal recommendations. For individual applications, all recommen- Editorial Director dations must be considered in light of the patient’s clinical David Moreau condition and, before administration of new or infrequently Clinical Director used drugs, in light of the latest package-insert information. Joan M. Robinson, RN, MSN The authors and publisher disclaim any responsibility for any adverse effects resulting from the suggested procedures, from Art Director any undetected errors, or from the reader’s misunderstanding Mary Ludwicki of the text. Clinical Project Manager © 2009 by Lippincott Williams & Wilkins. All rights reserved. Jennifer Meyering, RN, BSN, MS, CCRN This book is protected by copyright. No part of it may be repro- Editors duced, stored in a retrieval system, or transmitted, in any form or by any means—electronic, mechanical, photocopy, record- Margaret Eckman, Diane Labus ing, or otherwise—without prior written permission of the Copy Editors publisher, except for brief quotations embodied in critical arti- Kimberly Bilotta (supervisor), Jane Bradford, cles and reviews and testing and evaluation materials provid- Shana Harrington, Lisa Stockslager, ed by publisher to instructors whose schools have adopted its accompanying textbook. Printed in the United States of Ameri- Dorothy P. Terry, Pamela Wingrod ca. For information, write Lippincott Williams & Wilkins, 323 Designer Norristown Road, Suite 200, Ambler, PA 19002-2756. Georg W. Purvis IV CPIE3E—010608 Illustrator Bot Roda Digital Composition Services Diane Paluba (manager), Joy Rossi Biletz, Donna S. Morris Associate Manufacturing Manager Beth J. Welsh Editorial Assistants Karen J. Kirk, Jeri O’Shea, Linda K. Ruhf Indexer Barbara Hodgson Library of Congress Cataloging-in-Publication Data Clinical pharmacology made incredibly easy!. — 3rd ed. p. ; cm. Includes bibliographical references and index. 1. Clinical pharmacology — Outlines, syllabi, etc. I. Lippincott Williams & Wilkins. [DNLM: 1. Pharmacology, Clinical — methods — Hand books. 2. Drug Therapy — Handbooks. 3. Pharmaceutical Preparations — Handbooks. QV 39 C6417 2008] RM301.28.C556 2008 615'.1—dc22 ISBN-13: 978-0-7817-8938-7 (alk. paper) ISBN-10: 0-7817-8938-9 (alk. paper) 2008009967 938900FM.qxd 08/26/2008 18:11 Page v Contents Contributors and consultants vii Not another boring foreword ix 1 Fundamentals of clinical pharmacology 1 2 Autonomic nervous system drugs 21 3 Neurologic and neuromuscular drugs 49 4 Pain medications 93 5 Cardiovascular drugs 119 6 Hematologic drugs 155 7 Respiratory drugs 175 8 Gastrointestinal drugs 195 9 Genitourinary drugs 223 10 Anti-infective drugs 237 11 Anti-inflammatory, anti-allergy, and immunosuppressant drugs 293 12 Psychotropic drugs 311 13 Endocrine drugs 339 14 Drugs for fluid and electrolyte balance 359 15 Antineoplastic drugs 371 Other major drugs 414 Vaccines and treatment for biological weapons exposure 421 Treatment and antidotes for chemical weapons exposure 422 Herbal drugs 423 Selected references 426 Index 427 Internet drug updates eDruginfo.com v 938900FM.qxd 08/26/2008 18:11 Page vi 938900FM.qxd 08/26/2008 18:11 Page vii Contributors and consultants Tricia M. Berry, PharmD, BCPS Samantha P. Jellinek, PharmD, BCPS Associate Professor of Pharmacy Practice Clinical Pharmacy Manager for Medication Reconciliation & St. Louis College of Pharmacy Safety Clinical Coordinator, Pharmacy Practice Residency Program Victor Cohen, BS, PharmD,BCPS Maimonides Medical Center Assistant Professor of Pharmacy Practice Brooklyn, N.Y. Arnold & Marie Schwartz College of Pharmacy & Health Sciences Christine K. O’Neil, PharmD, BCPS, CGP, FCCP Clinical Pharmacy Manager & Residency Program Director Professor of Pharmacy Practice Maimonides Medical Center Duquesne University Brooklyn, N.Y. Mylan School of Pharmacy Pittsburgh Jason C. Cooper, PharmD Clinical Specialist, MUSC Drug Information Center Jean Scholtz, PharmD, BCPS, FASHP Medical University of South Carolina Associate Professor Charleston Department of Pharmacy Practice and Pharmacy Administration University of the Sciences in Philadelphia Michele A. Danish, PharmD, RPH Pharmacy Clinical Manager Anthony P. Sorrentino, PharmD St. Joseph Health Services Assistant Professor of Clinical Pharmacy North Providence, R.I. Philadelphia College of Pharmacy University of the Sciences in Philadelphia Glen E. Farr, PharmD Professor of Clinical Pharmacy & Associate Dean Suzzanne Tairu, PharmD University of Tennessee College of Pharmacy Clinical Specialist Knoxville The Medical Affairs Company/Consultant for Pfizer Kennesaw, Calif. Tatyana Gurvich, PharmD Clinical Pharmacologist Karen Jo Tietze, BS, PharmD Glendale (Calif.) Adventist Family Practice Residency Program Professor of Clinical Pharmacy Philadelphia College of Pharmacy Catherine A. Heyneman, PharmD, MS, ANP University of the Sciences in Philadelphia Associate Professor of Pharmacy Practice Idaho State University College of Pharmacy Pocatello vii 938900FM.qxd 08/26/2008 18:11 Page viii

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