Clinical Ophthalmic Oncology: Orbital Tumors

222 Pages·2014·14.76 MB·English

by  Sandy X. Zhang-Nunes MD

Julian D. Perry · Arun D. Singh
Editors
Clinical
OOpphhtthhaallmmiicc OOnnccoollooggyy
Orbital Tumors
Second Edition
123
Clinical Ophthalmic Oncology

Julian D. Perry (cid:129) A run D. Singh
Editors
Clinical Ophthalmic
Oncology
Orbital Tumors

Second Edition
Editors
Julian D. Perry, MD Arun D. Singh, MD
Division of Opthalmology Department of Ophthalmic Oncology
Cole Eye Institute Cole Eye Institute
Cleveland Clinic Foundation Cleveland Clinic Foundation
Cleveland , OH Cleveland , OH
USA USA
ISBN 978-3-642-40491-7 ISBN 978-3-642-40492-4 (eBook)
DOI 10.1007/978-3-642-40492-4
Springer Heidelberg New York Dordrecht London
Library of Congress Control Number: 2013956346
© Springer-Verlag Berlin Heidelberg 2014
First edition originally published by © Saunders, 2007
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To Clifford, Agnes, Jim, and Cliff for my foundation; to Bob,
Norm, and Neil for my education; to Julian, Liam, and Remy
for my inspiration. (JDP)
To my parents who educated me beyond their means, my wife
Annapurna, and my children, Nakul and Rahul, who make all
my efforts worthwhile. (ADS)
v

Pref ace
The management of patients with an ophthalmic tumor presents particular
challenges. Ophthalmic tumors are rare and diverse so that their diagnosis
can be quite complex. Treatment usually requires special expertise and
equipment and in many instances is controversial. The fi eld is advancing
rapidly because of accelerating progress in tumor biology, pharmacology,
and instrumentation. Increasingly, the care of patients with an ocular or
adnexal tumor is provided by a multidisciplinary team, comprising of ocular
oncologists, general oncologists, radiotherapists, pathologists, psycholo-
gists, and other specialists. For all these reasons, we felt that there was a
continued need for a textbook of ophthalmic oncology, which would amal-
gamate knowledge from several different disciplines, thereby helping the
various specialists to understand each other better and to cooperate more
effi ciently eventually moving ophthalmic oncology in the realm of evidence-
based medicine.
As several important studies have been published in recent years, the
purpose of Clinical Ophthalmic Oncology (2nd edition) is to provide up-to-
date information of the whole spectrum of the eyelid, conjunctival, intraocu-
lar, and orbital tumors including basic principles of chemotherapy, radiation
therapy, cancer epidemiology, angiogenesis, and cancer genetics. Several
chapters authored by radiation oncologists, medical physicists, pediatric
oncologists, hematologist-oncologists, and medical geneticists have been
included to provide a broader perspective.
Although each section of C linical Ophthalmic Oncology now represents a
stand-alone volume, each chapter has a similar layout with boxes that high-
light the key features, tables that provide comparison, and fl ow diagrams that
outline therapeutic approaches. Each chapter has been edited (with author’s
approval) to present a balanced view of current clinical practice, and special
attention has been paid to make the text easily readable.
The authors followed a tight timeline to keep the contents of the book cur-
rent. As we undertook this ambitious task of editing a multiauthor, multivol-
ume textbook, we were supported and guided by the staff at Springer: Sverre
Klemp, Ulrike Huesken, Ellen Blasig, the staff at SPi Global, India. Jennifer
Brown kept the seemingly chaotic process under control.
vii
viii Preface
It is our sincere hope that readers will fi nd as much pleasure reading this
volume as we had writing and editing it. If you fi nd Clinical Ophthalmic
Oncology informative, it is because (paraphrasing Isaac Newton), “we have
seen further, by standing on the shoulders of the giants.”
Cleveland, OH, USA Julian D. Perry, MD
Cleveland, OH, USA Arun D. Singh, MD
Contents
1 Examination Techniques. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Sandy X. Zhang-Nunes, Jill A. Foster,
and Julian D. Perry
2 Classifi cation of Orbital Tumors . . . . . . . . . . . . . . . . . . . . . . . . 9
Bryan R. Costin, Julian D. Perry, and Jill A. Foster
3 Differential Diagnosis in Children . . . . . . . . . . . . . . . . . . . . . . . 15
Sandy X. Zhang-Nunes, Jill A. Foster, Julian D. Perry,
and Paul L. Proffer
4 Differential Diagnosis in Adults . . . . . . . . . . . . . . . . . . . . . . . . . 21
Bryan R. Costin, Julian D. Perry, and Jill A. Foster
5 Imaging Techniques. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Patrick De Potter
6 Nonspecifi c Orbital Infl ammation . . . . . . . . . . . . . . . . . . . . . . . 45
Roberta E. Gausas, M.R. Damani,
and Kimberly P. Cockerham
7 Orbital Vascular Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
Bryan R. Costin and Julian D. Perry
8 Benign Orbital Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Bhupendra C.K. Patel
9 Optic Nerve Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
Jonathan J. Dutton
10 Lacrimal Gland Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105
David H. Verity, Omar M. Durrani,
and Geoffrey E. Rose
11 Lacrimal Sac Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115
Jacob Pe’er
12 Orbital and Adnexal Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . 123
Mary E. Aronow, Brian T. Hill, and Arun D. Singh
13 Malignant Orbital Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Bhupendra C.K. Patel
ix