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Clinical Haematology, Second Edition: Illustrated Clinical Cases PDF

352 Pages·2018·23.301 MB·English
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Clinical Haematology SECOND EDITION ILLUSTRATED CLINICAL CASES Clinical Haematology SECOND EDITION ATUL B. MEHTA MA, MD, FRCP, FRCPath Haemophilia Centre and Thrombosis Unit Royal Free London NHS Foundation Trust London, UK KEITH GOMEZ MBBS, PhD, MRCP, FRCPath Haemophilia Centre and Thrombosis Unit Royal Free London NHS Foundation Trust London, UK CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2018 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper International Standard Book Number-13: 978-1-4822-4379-6 (Paperback); 978-1-138-63591-3 (Hardback) This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been made to publish reliable data and information, neither the author[s] nor the publisher can accept any legal responsibility or liability for any errors or omissions that may be made. The publishers wish to make clear that any views or opinions expressed in this book by individual editors, authors or contributors are personal to them and do not necessarily reflect the views/opinions of the publishers. The information or guidance contained in this book is intended for use by medical, scientific or health-care professionals and is provided strictly as a supplement to the medical or other professional’s own judgement, their knowledge of the patient’s medical history, relevant manufacturer’s instructions and the appropriate best practice guidelines. Because of the rapid advances in medical science, any information or advice on dosages, procedures or diagnoses should be independently verified. The reader is strongly urged to consult the relevant national drug formulary and the drug companies’ and device or material manufacturers’ printed instructions, and their websites, before administering or utilizing any of the drugs, devices or materials mentioned in this book. This book does not indicate whether a particular treatment is appropriate or suitable for a particular individual. Ultimately it is the sole responsibility of the medical professional to make his or her own professional judgements, so as to advise and treat patients appropriately. The authors and publishers have also attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http:// www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Names: Mehta, Atul B., author. | Gomez, Keith, author. Title: Clinical haematology / Atul B. Mehta and Keith Gomez. Other titles: Self-assessment colour review of clinical haematology | Illustrated clinical cases. Description: Second edition. | Boca Raton : CRC Press, [2018] | Series: Illustrated clinical cases | Preceded by Self-assessment colour review of clinical haematology / Atul B. Mehta. London : Manson Pub., “1995. Identifiers: LCCN 2016051832| ISBN 9781482243796 (pbk. : alk. paper) | ISBN 9781138635913 (hardback : alk. paper) Subjects: | MESH: Hematologic Diseases–diagnosis | Hematologic Diseases–therapy | Case Reports Classification: LCC RC636 | NLM WH 120 | DDC 616.1/5–dc23 LC record available at https://lccn.loc.gov/2016051832 Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com CONTENTS Foreword vii Acknowledgements ix List of abbreviations xi Section I: General and malignant haematology 1 Cases 1–71 Section II: Coagulation 229 Cases 72–98 Section III: Quality control 319 Cases 99–101 Index 333 v FOREWORD In his foreword to the first edition of Clinical Haematology, Professor Luccio Luzzatto identified the interest in a combined laboratory and clinical specialty as one of the key features that attract young clinicians to haematology. This continues to be the case and it is this interest in interpret- ing laboratory data relevant to a clinical presentation that haematologists find compelling. This attraction is also evident in clinical laboratory scientists who are likewise drawn to the clinical interface in their roles in data interpretation and quality assurance. Atul Mehta and Keith Gomez have produced a book which absolutely captures the essence of clinical haematology, using a range of clinical histories illustrated with numerous different forms of diagnostic material, from clinical photographs to photomicrographs of blood and bone marrow, CT, MRI, and PET scans, haemoglobin electrophoresis and HPLC, FACS plots, and platelet aggregation, to mention a few. The book takes us through general and malignant hae- matology to haemostasis and thrombosis, and finishes with several scenarios related to quality control and quality assurance. What I really like about this book is the way the cases are presented, such that the reader ends up working through them in a way that replicates the process in real life. I think this book will appeal to trainees in medicine and especially trainees in haematology. There is little doubt that those preparing for exit exams in haematology such as the membership of the Royal College of Pathologists UK, and similar, will find this book helpful. In addition, the book will appeal to clinical scientists, established consultants and specialty grade doctors practising haematology. I would like to congratulate both authors on their book and hope that their readers enjoy working through the cases as much as I did. Henry Watson Chief Examiner for Haematology, Royal College of Pathologists London, UK Consultant Haematologist, NHS Grampian Aberdeen, UK vii ACKNOWLEDGEMENTS We wish to acknowledge the help and support of medical and scientific colleagues in the Department of Haematology, Royal Free Hospital and School of Medicine, and in our Medical Illustration Department. With a Foreword by Dr. Henry Watson Royal College of Pathologists London, UK Atul B. Mehta, MA, MD, FRCP, FRCPath Keith Gomez, MBBS, PhD, MRCP, FRCPath ix

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