Table Of Content

Clinical Endocrinology Edited by J. A. H. Wass and P. H. Bayliss Editorial Assistant W. F. Kelly Volume 39 1993 BLACKWELL SCIENTIFIC PUBLICATIONS OXFORD LONDON EDINBURGH BOSTON MELBOURNE PARIS BERLIN VIENNA 1993 Blackwell Scientific Publications Ltd. Authorization to photocopy for internal or personal use or the internal or personal use of specific clients is granted by Blackwell Scientific Publications Ltd for libraries and other users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the base fee of $10.00 per copy is paid directly to the CCC, 27 Congress Street, Salem, MA 01970, USA. This consent does not extend to other kinds of copying, such as copying for general distribution for advertising or promotional purposes, for creating new collective works or for resale. Special requests should be addressed to the Editor. 0300-0664/93/$10.00. Blackwell Scientific Publications Oxford London Edinburgh Boston Melbourne Paris Berlin Vienna ISSN 0300-0664 Printed in Great Britain at The Alden Press, Oxford Clinical Endocrinology (1993) 39, iii-vii Contents Volume 39, Number 1, July 1993 Review The impact of obesity on hyperandrogenism Effects of growth hormone therapy on the and polycystic ovary syndrome in premenopausal developmental changes of follicle stimulating women: R. PASQUALI and F. CASIMIRRI hormone and insulin-like growth factor-I serum Commentary Glucokinase and non-insulin-dependent concentrations in Turner’s syndrome: diabetes: Ss. O’RAHILLY J-P. BOURGUIGNON, A. GERARD, G. DEBY-DUPONT Proinsulin, proinsulin intermediate and insulin in and P. FRANCHIMONT cystic fibrosis: 1. HAMDI, M. GREEN, Longitudinal evaluation of adrenocorticotrophin and J. M. SHNEERSON, C. R. PALMER and C. N. HALES B-lipotrophin plasma levels following bilateral Elevated serum immunoreactive inhibin levels in adrenalectomy in patients with Cushing’s disease: peripubertal boys with chronic renal failure: A. C. MOREIRA, M. CASTRO and H. R. MACHADO R. MITCHELL, F. SCHAEFER, I. D. MORRIS, An audit of dynamic function tests: errors in the K. SCHARER, J. G. SUN, W. R. ROBERTSON and THE timing of blood specimens: J. H. BARTH, M. D. PAGE COOPERATIVE STUDY GROUP ON PUBERTAL and I. R. BAILEY DEVELOPMENT IN CHRONIC RENAL FAILURE Interindividual differences in the pituitary—thyroid (CSPCRF) axis influence the interpretation of thyroid function Premature ovarian failure: autoimmunity and natural tests: C. A. MEIER, M. N. MAISEY, A. LOWRY, history: C. BETTERLE, A. ROSSI, S. DALLA PRIA, J. MULLER and M. A. SMITH A. ARTIFONI, B. PEDINI, S. GAVASSO and A. CARETTO Case report Serious, prolonged hypoglycaemia with Effect of varying concentrations of follicle stimulating glibenclamide in a patient with Mendenhall’s hormone on the production of gonadotrophin surge syndrome: S. KUMAR and A. J. MBOULTON attenuating factor (GnSAF) in women: Case report Severe peripheral neuropathy and I. E. MESSINIS, D. LOLIS, L. PAPADOPOULOS, elevated plantar pressures causing foot ulceration in TH. TSAHALINA, N. PAPANIKOLAOU, K. SEFERIADIS pituitary gigantism: A. M.JENNINGS, A. ROBINSON, and A. A. TEMPLETON R. H. KANDLER, R. P. BETTS, R. E. J. REYDER and Peptide «-amidation activity in human plasma: D. R. CULLEN relationship to gastrin processing: M. KAPUSCINSKI, Rapid communication The effect of recombinant M. GREEN, S. N. SINHA, J. J. SHEPHERD and human insulin-like growth factor-I treatment on A. SHULKES growth hormone secretion in two subjects with Calcitonin gene-related peptide in small cell lung growth hormone insensitivity (Laron syndrome): carcinomas: S. SCHIFTER, L. JOHANNSEN, A. M. COTTERILL, C. CAMACHO-HUBNER, C. BUNKER, P. BRICKELL, E. BORK, H. LINDBERG J. M. P. HOLLY and M. O. SAVAGE and J. FABER Letter to the Editors Prevalence of subclinical hyperthyroidism and Book reviews relationship between thyroid hormonal status and Notices thyroid ultrasonographic parameters in patients with non-toxic nodular goitre: M. RIEU, S. BEKKA, B. SAMBOR, J-L. BERROD and J-P. FOMBEUR Relation between phenotype and intra-cellular thyroid hormone effect in patients with altered peripheral Volume 39, Number 2, August 1993 thyroid hormone sensitivity: J. KVETNY and J. BOLLERSLEV Effect of growth hormone administration frequency 131 Review The cellular and molecular basis of the on 24-hour growth hormone profiles and levels of ectopic ACTH syndrome: A. WHITE and other growth related parameters in girls with Turner’s A.J. L. CLARK syndrome: A. VAN TEUNENBROEK, Current therapy The treatment of women with S. M. P. F. DE MUINCK KEIZER-SCHRAMA, hirsutism: W. JEFFCOATE T. STIJNEN, J. W. MOUTON, W. F. BLUM, 17-Hydroxyprogesterone response to buserelin testing M. MERCADO, G. BAUMANN, S. L. S. DROP and THE in the polycystic ovary syndrome: Y. SAHIN and DUTCH WORKING GROUP ON GROWTH HORMONE K. KELESTIMUR iv Contents Clinical Endocrinology (1993) 39 The impact of a pure anti-androgen (flutamide) on The combined use of intravenous and oral calcium for LH, FSH, androgens and clinical status in idiopathic the treatment of vitamin D dependent rickets type II hirsutism: B. COUZINET, M. PHOLSENA, J. YOUNG (VDDRII): A. AL-AQEEL, P. OZAND, S. SOBKI, and G. SCHAISON W. SEWAIRI and S. MARX Circadian variation in serum free and non-SHBG- Case of the Month Ac ase of antibody formation bound testosterone in normal men: measurements, against octreotide visualized with '''In-octreotide and simulation using a mass action model: scintigraphy: D. J. KWEKKEBOOM, J. ASSIES, R. R. COOKE, J. E. A. MCINTOSH and L. J. HOFLAND, J. C. REUBI, S. W. J. LAMBERTS and R. P. MCINTOSH E. P. KRENNING Molecular heterogeneity of serum follicle-stimulating Commentary: H. ORSKOV hormone in hypogonadal patients before and during Case report Deoxycorticosterone, 11f-hydroxylase androgen replacement therapy and in normal men: and the adrenal cortex: H. A. SPOUDEAS, I. A. HARSCH, M. SIMONI and E. NIESCHLAG J. D. H. SLATER, G. RUMSBY, J. W. HONOUR and Cc. G. D. BROOK Ovarian electrocauterization causes LH-regulated but Case report Thyrotoxicosis increases right to left not insulin-regulated endocrine changes: A. TIITINEN, shunt in congenital cyanotic heart disease: A. TENHUNEN and M. SEPPALA S. M. ORME, J. P. SEBASTIAN, M. D. PAGE, Evening administration of melatonin enhances the C. COWAN and P. E. BELCHETZ pulsatile secretion of prolactin but not of LH and 257 Notices TSH in normally cycling women: M. TERZOLO, A. REVELLI, D. GUIDETTI, A. PIOVESAN, P. CASSONI, P. PACCOTTI, A. ANGELI and M. MASSOBRIO Melatonin stimulates growth hormone secretion through pathways other than the growth hormone- releasing hormone: R. VALCAVI, M. ZINI, Volume 39, Number 3, September 1993 G. J. MAESTRONI, A. CONTI and I. PORTIOLI Urinary growth hormone excretion in the assessment of children with disorders of growth: A. M. SKINNER, 259 Review Endothelins as regulators of growth and P. E. CLAYTON, D. A. PRICE, G. M. ADDISON and function in endocrine tissues: R. L. KENNEDY, A. SOO W. G. HAYNES and D. J. WEBB In-vitro response of erythroid progenitors from Commentary Thyrotrophin receptor expression: does children with thalassaemia major to human growth it help in assessing the prognosis of thyroid cancer?: M. C. SHEPPARD hormone and insulin-like growth factor I: S. MERCHAV, Z. GRAIF and A. SKOTTNER Expression of thyrotrophin receptor gene in thyroid carcinoma is associated with a good prognosis: Enhanced prolactin responsiveness to galanin in YUFEI SHI, MINJING ZOU and N. R. FARID patients with Cushing’s disease: C. INVITTI, The importance of thyroid microsomal antibodies in F. P. GIRALDI, A. TAGLIAFERRI, M. SCACCHI, the development of elevated serum TSH in middle- A. DUBINI and F. CAVAGNINI aged women: associations with serum lipids: Protein intake during aggressive calorie restriction in K. W. GEUL, I. L. L. VAN SLUISVELD, obesity determines growth hormone response to D. E. GROBBEE, R. DOCTER, A. M. DE BRUYN, growth hormone-releasing hormone after weight loss: H. HOOYKAAS, J. P. VAN DER MERWE, A. MEGIA, L. HERRANZ, R. LUNA, A. M. VAN HEMERT, E. P. KRENNING, C. GOMEZ-CANDELA, F. PALLARDO and G. HENNEMANN and R. F. A. WEBER P. GONZALEZ-GANCEDO The effect of treatment with levothyroxine or iodine Deficient inactivation of cortisol by on thyroid size and thyroid growth stimulating 11B-hydroxysteroid dehydrogenase in essential immunoglobulins in endemic goitre patients: hypertension: B. R. WALKER, P. M. STEWART, M. M. WILDERS-TRUSCHNIG, H. WARNKROB, G. LEB, C. H. L. SHACKLETON, P. L. PADFIELD and W. LANGSTEGER, O. EBER, A. TIRAN, H. DOBNIG, c. R. W. EDWARDS A. PASSATH, G. LANZER and H. A. DREXHAGE Clinical Endocrinology (1993) 39 Contents Prospective study of the hypothalamic-—pituitary axis 363 Response of sex hormone binding globulin and in thalassaemic patients who developed secondary insulin-like growth factor binding protein-1 to an oral amenorrhoea: R. CHATTERJEE, M. KATZ, T. F. COX glucose tolerance test in obese women with polycystic and J. B. PORTER ovary syndrome before and after calorie restriction: Adrenocorticotrophin and cortisol secretion in D. HAMILTON-FAIRLEY, D. KIDDY, V. ANYAOKU, children after low dose cranial irradiation: R. KOISTINEN, M. SEPPALA and S. FRANKS E. C. CROWNE, W. H. B. WALLACE, S. GIBSON, Pharmacokinetic properties of the tocolytic agent C. M. MOORE, A. WHITE and S. M. SHALET [Mpa!, p-Tyr(Et)’, Thr*, Orn*]-oxytocin (antocin) in Comparison of computerized tomography and healthy volunteers: $. LUNDIN, A. BROEDERS and P. MELIN magnetic resonance imaging for the examination of Case report ACTH-independent Cushing’s syndrome the pituitary gland in patients with Cushing’s disease: H. ESCOUROLLE, J. P. ABECASSIS, X. BERTAGNA, in pregnancy with spontaneous resolution after B. GUILHAUME, D. PARIENTE, P. DEROME, delivery: control of the hypercortisolism with A. BONNIN and J. P. LUTON metyrapone: C. F. CLOSE, M. C. MANN, J. F. WATTS and K. G. TAYLOR Bilateral adrenalectomy: low mortality and morbidity Case report Isolated congenital ACTH deficiency: in Cushing’s disease: D. R. MCCANCE, a cleavage enzyme defect?: s. S. NUSSEY, C. F. J. RUSSELL, T. L. KENNEDY, D. R. HADDEN, SHIU-CHING SOO, S. GIBSON, I. GOUT, A. WHITE, L. KENNEDY and A. B. ATKINSON M. BAIN and A. P. JOHNSTONE The efficacy and tolerability of long-term cabergoline Commentary Isolated ACTH deficiency: enzyme therapy in hyperprolactinaemic disorders: an open, defect or chimaeric enzyme?: J. W. FUNDER and uncontrolled, multicentre study: J. WEBSTER, A. I. SMITH G. PISCITELLI, A. POLLI, A. D’ALBERTON, Notices L. FALSETTI, C. FERRARI, P. FIORETTI, G. GIORDANO, M. L’HERMITE, E. CICCARELLI, P. G. CROSIGNANI, L. DECECCO, R. FADINI, G. FAGLIA, C. FLAMIGNI, G. TAMBURRANO, I. ISMAIL and M. F. SCANLON The short and long-term effects of octreotide on Volume 39, Number 4, October 1993 calcium homeostasis in patients with acromegaly: L. FREDSTORP, Y. PERNOW and S. WERNER Metabolic clearance rate of biosynthetic growth 389 Review The effects of drugs on endocrine function: hormone after endogenous growth hormone M. P. J. VANDERPUMP and W. M. G. TUNBRIDGE suppression with a somatostatin analogue in chronic 399 Invited Commentary Pancreatic and islet renal failure patients and control subjects: transplantation for diabetes: D. A. PYKE R. V. G. GARCIA-MAYOR, A. J. PEREZ, A. GANDARA, 401 Commentary Growth hormone replacement in adults: A. ANDRADE, F. MALLO and F. F. CASANUEVA What dose?: R. J. M. ROSS Growth hormone dose regimens in adult GH Hyperactivity of the hypothalamo-pituitary—adrenal deficiency: effects on biochemical growth markers and axis in obesity: a study of ACTH, AVP, f-lipotrophin metabolic parameters: J. MOLLER, and cortisol responses to insulin-induced J. O. L. JORGENSEN, T. LAUERSEN, J. FRYSTYK, hypoglycaemia: J. U. WEAVER, P. G. KOPELMAN, R. W. NARAA, H. ORSKOV and J. S. CHRISTIANSEN L. MCLOUGHLIN, M. L. FORSLING and A. GROSSMAN Short and long-term effects of growth hormone The relationship of insulin insensitivity to menstrual treatment on bone turnover and bone mineral content pattern in women with hyperandrogenism and in adult growth hormone-deficient males: polycystic ovaries: S. ROBINSON, D. KIDDY, M. VANDEWEGHE, P. TAELMAN and J.-M. KAUFMAN S. V. GELDING, D. WILLIS, R. NITHTHYANANTHAN, Carpal tunnel syndrome and gynaecomastia during A. BUSH, D. G. JOHNSTON and S. FRANKS growth hormone treatment of elderly men with low The regulation of insulin-like growth factor binding circulating IGF-I concentrations: L. COHN, protein (IGFBP)-1 during prolonged fasting: A. G. FELLER, M. W. DRAPER, I. W. RUDMAN and A. M. COTTERILL, J. M. P. HOLLY and J. A. H. WASS D. RUDMAN Contents Clinical Endocrinology (1993) 39 Plasma IGFBP-3 and its relationship with Volume 39, Number 5, November 1993 quantitative growth hormone secretion in short children: M. PHILLIP, S. A. CHALEW, 499 Review The sick euthyroid syndrome: changes in A. A. KOWARSKI and M. A. STONE thyroid hormone serum parameters and hormone Pituitary adenomas with high and low basal inositol metabolism: R. DOCTER, E. P. KRENNING, phospholipid turnover; the stimulatory effect of kinins M. DE JONG and G. HENNEMANN and an association with interleukin-6 secretion: Commentary Thyroid hormone therapy and the T. H. JONES, R. L. KENNEDY, S. K. JUSTICE and skeleton: J. E. COMPSTON A. PRICE Bone mineral density in patients with endogenous The relationship between cortisol production rate and subclinical hyperthyroidism: Is this thyroid status a serial serum cortisol estimation in patients on medical risk factor for osteoporosis?: J. FOLDES, G. TARJAN, therapy for Cushing’s syndrome: P. J. TRAINER, M. SZATHMARI, F. VARGA, I. KRASNAI and C. EASTMENT, A. B. GROSSMAN, M. J. WHEELER, CS. HORVATH L. PERRY and G. M. BESSER Suppressed TSH levels secondary to thyroxine Discrimination between f-endorphin and B-lipotrophin in human plasma using two-site replacement therapy are not associated with osteoporosis: D. J. GRANT, M. E. T. MCMURDO, immunoradiometric assays: S. GIBSON, S. R. CROSBY P. A. MOLE, C. R. PATERSON and R. R. DAVIES and A. WHITE Thyroid dysfunction in African trypanosomiasis: a Thyroxine suppressive therapy decreases bone mineral possible role for inflammatory cytokines: density in post-menopausal women: A. W. C. KUNG, M. REINCKE, B. ALLOLIO, F. PETZKE, C. HEPPNER, T. LORENTZ and S. C. F. TAM D. MBULAMBERI, D. VOLLMER, W. WINKELMANN A long-term follow-up study of patients with non- and G. P. CHROUSOS toxic goitre in Japan: T. HARA, H. TAMAI, Response of plasma low density lipoprotein T. MUKUTA, S. FUKATA, K. KUMA and subfractions to oestrogen replacement therapy T. NAKAGAWA following surgical menopause: B. GRIFFIN, E. FARISH, Commentary Variable androgen sensitivity in D. WALSH, J. BARNES, M. CASLAKE, J. SHEPHERD relationship to hirsutism and acne: T. J. MCKENNA and D. HART Two different pathogenetic mechanisms may play a The determination of delta-5-androstenediol and its role in acne and in hirsutism: v. TOSCANO, sulphate in serum and urine by gas chromatography- R. BALDUCCI, P. BIANCHI, R. GUGLIELMI, mass spectrometry: L. D. DIKKESCHEI, A. MANGIANTINI, F. G. ROSSI, L. M. COLONNA and B. G. WOLTHERS, P. H. B. WILLEMSE, H. VAN DER F. SCIARRA POL, A. W. DE RUYTER-BUITENHUIS and G. T. NAGEL Plasma 19-hydroxyandrostenedione is elevated in Delta-S-androstenediol and its sulphate in serum and patients with high renin essential hypertension: urine of normal adults and patients with endocrine N. SEKIHARA, K. YONEMITSU and Y. YAZAKI diseases: L. D. DIKKESCHEI, P. H. B. WILLEMSE, B. G. WOLTHERS, A. W. DE RUYTER-BUITENHUIS Effects of different oral oestrogen formulations on and G. T. NAGEL insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal Combined 17a-hydroxylase/17,20-lyase deficiency women: J. J. KELLY, I. A. RAJKOVIC, caused by heterozygous stop codons in the A. J. O'SULLIVAN, C. SERNIA and K. K. Y. HO cytochrome P450 17a-hydroxylase gene: G. RUMSBY, C. SKINNER, H. A. LEE and J. W. HONOUR Effect of oestrogen status on serum levels of growth Pregnancy associated osteoporosis: F. DUNNE, hormone-binding protein and insulin-like growth B. WALTERS, T. MARSHALL and D. A. HEATH factor I in non-pregnant women: G. MASSA, Case report Direct in-vivo detection of atypical A. IGOUT, L. ROMBAUTS, F. FRANKENNE and hormonal expression of a Sertoli-Leydig cell tumour M. VANDERSCHUEREN-LODEWEYCKX following stimulation with human chorionic Impact of 2 weeks high dose growth hormone gonadotrophin: I. COHEN, M. SHAPIRA, treatment on basal and insulin stimulated substrate S. CUPERMAN, S. GOLDBERGER, A. SIEGAL, metabolism in humans: N. MOLLER, J. MOLLER, M. ALTARAS and Y. BEYTH J. O. L. JORGENSEN, P. OVESEN, O. SCHMITZ, Notices K. G. M. M. ALBERT and J. S. CHRISTIANSEN Clinical Endocrinology (1993) 39 Contents vii 583 Insulin-like growth factor-I blood levels in severely Reversibility of thyroid dysfunction induced by burned patients: effects of time post injury, age of recombinant alpha interferon in chronic hepatitis C: patient and severity of burn: T. ABRIBAT, E. BAUDIN, P. MARCELLIN, M. POUTEAU, P. BRAZEAU, I. DAVIGNON and D. R. GARREL N. COLAS-LINHART, J-P. LE FLOCH, C. LEMMONIER, Leucine metabolism in patients with Cushing’s J-P. BENHAMOU and B. BOK syndrome before and after successful treatment: Tissue resistance to 1,25-dihydroxyvitamin D without S. B. BOWES, J. J. BENN, I. N. SCOBIE, a mutation of the vitamin D receptor gene: A. M. UMPLEBY, C. LOWY and P. H. SONKSEN M.HEWISON, A. R. RUT, K. KRISTJANSSON, Abnormal twenty-four hour pattern of pulsatile R. E. WALKER, M. J. DILLON, M. R. HUGHES and luteinizing hormone secretion and the response to J. L. H. O’RIORDAN naloxone in women with hyperprolactinaemic The effect of morphine and naloxone administration amenorrhoea: C. C. K. TAY, A. F. GLASIER, on maternal oxytocin concentration in late pregnancy: P. J. ILLINGWORTH and D. T. BAIRD S. W. LINDOW, Z. M. VAN DER SPUY, Growth hormone treatment affects plasma LH M. S. HENDRICKS, F. A. NUGENT and T. T. DUNNE pulsatile release in women with secondary Recombinant human growth hormone therapy does amenorrhoea: A. D. GENAZZANI, F. PETRAGLIA, not increase microalbuminuria in children with short C. VOLPOGNI, F. PIANAZZI, V. MONTANINI, stature: D. LEVINE, P. KREITZER, S. FREEDMAN and G. D’AMBROGIO and A. R. GENAZZANI H. TRACHTMAN Case report Necrosis of a phaeochromocytoma Preliminary observations using endocrine markers of associated with spontaneous remission of diabetes pituitary venous dilution during bilateral and hypertension: L. ZANIN, G-P. ROSSI, simultaneous inferior petrosal sinus catheterization in A. POLETTI, A. PIOTTO, M. CHIESURA-CORONA and Cushing’s syndrome: Is combined CRF and TRH A. C. PESSINA stimulation of value?: P. G. MCNALLY, A. BOLIA, Case report Tissue-specific modulation of insulin S. R. ABSALOM, J. FALCONER-SMITH and receptor mRNA levels in a patient with a T. A. HOWLETT phaeochromocytoma: M. A. LEAL, P. ALLER, Modulation of IGF-I receptors by exogenous hGH A. TORRES, A. PICARDO and C. CALLE treatment in constitutionally short children: R. ESHET, B. KLINGER, A. SILBERGELD and Z. LARON Case of the Month Hypercalcaemia due to Volume 39, Number 6, December 1993 parathyroid hormone-related protein: long-term circulating levels may not reflect tumour activity: M. W. SAVAGE, W. D. FRASER, C. W. BODMER, 623 Review Clinical implications of hyperinsulinaemia in A. F. GINTY, J. A. GALLAGHER, J. ROBINSON and women: G. S. CONWAY and H. S. JACOBS G. WILLIAMS 633 Differences in testosterone metabolism by beard and Commentary E. B. MAWER scalp hair follicle dermal papilla cells: Letters to the Editors M. J. THORNTON, I. LAING, K. HAMADA, Book reviews A. G. MESSENGER and V. A. RANDALL Notices Alternate-day GnRH therapy for ovarian Referees hyperfunction induced by weight loss: treatment of six Author index patients who remained amenorrhoeic after weight Subject index gain: F. KOTSUJI, M. KUBO, Y. TAKEUCHI and T. TOMINAGA Effects of norethisterone on bone related biochemical variables and forearm bone mineral in post- menopausal osteoporosis: M. HOROWITZ, J. M. WISHART, A. G. NEED, H. A. MORRIS and B. E. C. NORDIN