Chronic Prostatitis/Chronic Pelvic Pain Syndrome

280 Pages·2008·2.25 MB·English

by  Carvell T. Nguyen

Chronic Prostatitis/Chronic
Pelvic Pain Syndrome
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W. McAninch, 2005
Management of Prostate Cancer, Second Edition, edited by Eric A. Klein, 2004
Essential Urology: A Guide to Clinical Practice, edited by Jeannette M. Potts, 2004
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Pediatric Urology, edited by John P. Gearhart, 2003
Laparoscopic Urologic Oncology, edited by Jeffrey A. Cadeddu, 2004
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and Patient Follow-Up, edited by Culley C. Carson, III, 2002
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Prostate Cancer Screening, edited by Ian M. Thompson, Martin I. Resnick, and Eric
A. Klein, 2001
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Chronic Prostatitis/Chronic
Pelvic Pain Syndrome
Edited by
Daniel A. Shoskes, MD
Glickman Urological and Kidney Institute, Cleveland Clinic,
Cleveland, Ohio
Editor
Daniel A. Shoskes, MD
Glickman Urological and Kidney Institute
Cleveland Clinic, Cleveland, Ohio
Series Editor
Eric A. Klein, MD
Professor of Surgery
Cleveland Clinic Lerner College of Medicine
Head, Section of Urologic Oncology
Glickman Urological and Kidney Institute
Cleveland, OH
ISBN: 978-1-934115-27-5 e-ISBN: 978-1-59745-472-8
Library of Congress Control Number: 2007938048
© 2008 Humana Press, a part of Springer Science + Business Media, LLC
All rights reserved. This work may not be translated or copied in whole or in part without the written
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Preface
Prostatitis is a clear enigma within urology; a group of conditions that is at once
extremely common, poorly understood, inadequately treated, and under-researched.
When I developed a research interest in the conditions about ten years ago, a careful
read of the literature to date was quite surprising. The classification system was
based upon the “4-glass test,” which was designed to help localize bacterial infec-
tions and had never been validated for other use. There was no validated symptom
score. There was not a single randomized placebo-controlled trial using symptoms
as an outcome. The condition was clearly a “wastebasket of urology.” When speak-
ing at academic meetings, I seldom failed to get a laugh adding “…and I’m not the
most junior member of the faculty” to my introduction.
Ten years later, much has changed. National Institutes of Health funding support
has brought new investigators into the field. We now have a classification system
based upon clinical syndromes rather than etiology (which is still unknown).
Outcomes research has improved our understanding of the incidence, quality of life
impact, and economic impact. We have a validated symptom score that appears to
adequately measure both symptom severity and response to therapy. Randomized
placebo-controlled trials are now the rule rather than the exception. Established
dogma on the investigation, therapy and indeed the prostatic origin for many men
with “chronic prostatitis” is being challenged.
The purpose of this book is to review the state of the art in prostatitis combining
practical clinical recommendations with cutting-edge clinical research, basic
science, and questions for the future. We have assembled a diverse international
group of contributors that includes urologists (academic, primary care, and front-
line private practice), scientists, psychologists, pain specialists, and directors from
the National Institute of Health. Chapters cover general evaluation of the prostatitis
patient; the approach to acute prostatitis; chronic bacterial prostatitis and chronic
pelvic pain syndrome; evidence behind individual therapies; and ancillary topics
such as erectile dysfunction, infertility, the link between chronic prostatitis and
prostate cancer; male interstitial cystitis; and the potential etiologic role of calcify-
ing nanoparticles. We conclude with reviews of where we have come from and
where we may be going and a practical summary chapter of therapy for chronic
pelvic pain syndrome based upon established data and clinical experience.
v
vi Preface
It is my sincere hope that readers can find novel approaches in this text to help
their patients. I also hope that in another ten years, we will be able to marvel at how
much more has been accomplished and how the suffering of men with prostatitis
has been eased.
Daniel A. Shoskes, MD
Contents
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
Chapter 1 Evaluation of the Prostatitis Patient . . . . . . . . . . . . . . . . . . . . . 1
Carvell T. Nguyen and Daniel A. Shoskes
Chapter 2 Acute Bacterial Prostatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Kurt G. Naber, Florian M. E. Wagenlehner,
and Wolfgang Weidner
Chapter 3 Chronic Bacterial Prostatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Wolfgang Weidner, Florian M. E. Wagenlehner,
and Kurt G. Naber
Chapter 4 Prostatitis in the Immunocompromised Patient . . . . . . . . . . . 45
Alain J. Duclos
Chapter 5 Quality of Life and Economic Impact
of Chronic Prostatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Elizabeth A. Calhoun, Anna M. S. Duloy,
and J. Quentin Clemens
Chapter 6 Antibiotic Therapy in Chronic Prostatitis/Chronic
Pelvic Pain Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Russell Blair Egerdie
Chapter 7 Alpha-Blocker Therapy for Chronic Prostatitis/Chronic
Pelvic Pain Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Shaun Wen Huey Lee, Men Long Liong, Kah Hay Yuen,
Yee Vonne Liong, and John N. Krieger
vii
viii Contents
Chapter 8 Phytotherapy and the Prostatitis Syndromes. . . . . . . . . . . . . 101
Daniel A. Shoskes
Chapter 9 Neuromuscular and Psychoactive Treatments
for Chronic Prostatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
Michel Pontari
Chapter 10 The Role of Surgery and Minimally Invasive
Prostate Therapies in Prostatitis . . . . . . . . . . . . . . . . . . . . . . . 125
Jonathan Bergman and Scott I. Zeitlin
Chapter 11 Physical Therapy for Chronic Prostatitis /Chronic
Pelvic Pain Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
Jeannette M. Potts
Chapter 12 A Biopsychosocial Therapy Model for Chronic
Prostatitis/Chronic Pelvic Pain Syndrome . . . . . . . . . . . . . . . 143
Dean A. Tripp
Chapter 13 Pain Management in Chronic Prostatitis . . . . . . . . . . . . . . . . 165
Amgad Abdu, Samer Narouze, and Nagy A. Mekhail
Chapter 14 Sexual Dysfunction and Infertility in Chronic
Prostatitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175
Lawrence S. Hakim
Chapter 15 Interstitial Cystitis in Men: Diagnosis, Treatment,
and Similarities to Chronic Prostatitis . . . . . . . . . . . . . . . . . . 189
Jonathan D. Kaye and Robert M. Moldwin
Chapter 16 Category IV Prostatitis: Implications for Prostate
Cancer Screening, Diagnosis, and Carcinogenesis . . . . . . . . 209
J. Stephen Jones
Chapter 17 The Role of Nanobacteria/Calcifying Nanoparticles
in Prostate Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
Jeffrey A. Jones, Neva Ciftcioglu, and David McKay
Chapter 18 Strategies for Increasing the Understanding
of Chronic Prostatitis/Chronic Pelvic Pain Syndrome . . . . . 245
John W. Kusek and Leroy M. Nyberg
Contents ix
Chapter 19 Chronic Prostatitis/Chronic Pelvic Pain Syndrome:
The Past, Present, and Future . . . . . . . . . . . . . . . . . . . . . . . . . 259
J. Curtis Nickel
Chapter 20 Therapy for Category III Prostatitis: A Synthesis . . . . . . . . 265
Daniel A. Shoskes
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273
Contributors
Amgad Abdu, MD
Pain Management Center, The Cleveland Clinic,
Cleveland, OH
Jonathan Bergman, MD
Department of Urology,
David Geffen School of Medicine at UCLA,
Los Angeles, CA
Elizabeth A. Calhoun, PhD
University of Illinois at Chicago, Chicago, IL
Neva Ciftcioglu, PhD
Nanobac Pharmaceuticals, Inc,
Lyndon B. Johnson Space Center, Houston, TX
J. Quentin Clemens, MD
Northwestern University, Feinberg School of Medicine, Chicago, IL
Alain Duclos, MD
University of Montreal, St-Luc Hospital, Montréal, Québec,
Canada
Anna M.S. Duloy, BE
University of Illinois at Chicago, Chicago, IL
Russell Blair Egerdie, M.D., F.R.C.S. (C)
University of Western Ontario, St. Mary’s General Hospital,
Urology Associates/Urologic Medical Research, Kitchener, Ontario, Canada
Lawrence S. Hakim, MD, FACS
Department of Urology, Cleveland Clinic Florida, Weston, FL
xi