Chronic Inflammation: Mechanisms and Regulation PDF
Preview Chronic Inflammation: Mechanisms and Regulation
Masayuki Miyasaka · Kiyoshi Takatsu Editors Chronic Infl ammation Mechanisms and Regulation Chronic Inflammation Masayuki Miyasaka • Kiyoshi Takatsu Editors Chronic Inflammation Mechanisms and Regulation Editors MasayukiMiyasaka KiyoshiTakatsu InterdisciplinaryProgramforBiomedical DepartmentofImmunobiologyand Sciences PharmacologicalGenetics InstituteforAcademicInitiatives GraduateSchoolofMedicineand OsakaUniversity PharmaceuticalSciences Suita,Japan UniversityofToyama Toyama,Japan WPIImmunologyFrontierCenter OsakaUniversity ToyamaPrefecturalInstituteforPharmaceutical Suita,Japan Research Toyama,Japan MediCityResearchLaboratory UniversityofTurku Turku,Finland ISBN978-4-431-56066-1 ISBN978-4-431-56068-5 (eBook) DOI10.1007/978-4-431-56068-5 LibraryofCongressControlNumber:2016945256 ©SpringerJapan2016 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilarmethodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthis book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained hereinorforanyerrorsoromissionsthatmayhavebeenmade. Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerJapanKK Preface Inflammation, a reaction characterized by redness, fever, swelling, and pain, has been considered a homeostatic tissue repair mechanism, which is evoked by the body in response to infections and/or tissue injury. However, accumulating evi- dence indicates that, when inflammation becomes chronic, it acts as a strong disease-promoting factor in a number of pathological disorders including arterio- sclerosis, obesity, cancer, and Alzheimer disease. Chronic inflammation also pro- motes aging. Despite such importance, the dismaying fact is that we know very little about why inflammatory reactions that would usually subside continue and becomechronic.Morespecifically,wedonotknowpreciselywhattypeoffactors induce chronic inflammation and promote its prolongation. Also we have little knowledge about how chronic inflammation causes tissue degeneration and other disorders.Furthermore, we have no effective treatmentagainst chronic inflamma- tionatpresent. Realizingthesesituations,akeyfundingbodyoftheGovernmentofJapan,the Japan Science and Technology Agency (JST), launched two major research pro- grams (CREST and PRESTO) on chronic inflammation in 2010; CRESTO is a fundingprogramforteam-oriented research, whereasPRESTO isforindependent research by young investigators. From 2010 until now, in the research area of chronicinflammation,17teamswereselectedforCRESTOandconductedresearch for5years(eachteamreceiving150–500millionyenintotal),and37researchers were selected and conducted research for 3–5 years in PRESTO (each scientist receiving30–40millionyenfor3-yearresearchand50–100millionyenfor5-year research). This book represents a compendium of such research efforts. Members of the CREST and PRESTO projects contributed a chapter on their own work, and research supervisors of the CRESTO and PRESTO projects (M.M. and K.T., respectively) edited the book. As you see in this book, thanks to the painstaking and persistent hard work by the CRESTO and PRESTO members, we are now beginning to understand what induces and maintains the chronicity of inflamma- tion,andwhatkindsofmechanismschronicinflammationutilizestoinducespecific v vi Preface diseasesincludingcancer,degenerativeneurologicaldisorders,andarteriosclerotic diseases.Wehavealsosucceededincreatingnoveltechnologiesthatallowforthe earlydetectionandquantitativeassessmentofchronicinflammation. Producingthisbookrequiredtheeffortsofmanypeoplewhodeservecreditand thanks.First,wewouldliketothankalltheCRESTO andPRESTO investigators, whoworkedstrenuouslyonthesubjectofchronicinflammationandcontributeda nicechapterforthebook.Second,ourspecialthanksgotoresearchofficersofJST and AMED (Japan Agency for Medical Research and Development) (CREST “Chronic Inflammation” is now under the supervision of AMED since 2015), particularly to Shinichi Kato (JST-CREST), Akihiko Kasahara (AMED-CREST), and Isao Serizawa (PRESTO), who kept the projects organized and meticulously preparedanumberofresearchmeetingsforthemembers.Third,weareindebtedto the editorial assistance by Yuko Matsumoto and Yasutaka Okazaki of Springer Japan.Fourth,wewishtoacknowledgetheconstantsupportandunderstandingof ourwives,ChiekoTakatsuandEtsukoMiyasaka.Finally,wethankyou,thereader, foryourinterestinthisresearchfield.Wewillbemorethanhappyifoureffortsare successfulinprovidingyouwithusefulandstimulatinginformationthatwillleadto newdevelopmentsinthefieldofchronicinflammation. Suita,Japan MasayukiMiyasaka Toyama,Japan KiyoshiTakatsu September2015 Contents PartI BasicMechanismsUnderlyingInduction,Progression,and ResolutionofChronicInflammation 1 ProstaglandinsinChronicInflammation. . . . . . . . . . . . . . . . . . . . 3 TomohiroAokiandShuhNarumiya 2 CellularandMolecularMechanismsofChronicInflammation- AssociatedOrganFibrosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 TatsuyaTsukui,ShigeyukiShichino,TakeshiShimaoka,SatoshiUeha, andKoujiMatsushima 3 Sema4AandChronicInflammation. . . . . . . . . . . . . . . . . . . . . . . . 37 DaisukeItoandAtsushiKumanogoh 4 MicroRNAsinChronicInflammation. . . . . . . . . . . . . . . . . . . . . . . 49 Y.Ito,S.Mokuda,K.Miyata,T.Matsushima,andH.Asahara 5 GeneticDissectionofAutoinflammatorySyndrome. . . . . . . . . . . . 63 KojiYasutomo 6 StructuralBiologyofChronicInflammation-AssociatedSignalling Pathways:TowardStructure-GuidedDrugDevelopment. . . . . . . . 77 ReiyaTaniguchiandOsamuNureki 7 LipidSignalsintheResolutionofInflammation. . . . . . . . . . . . . . . 89 MakotoArita 8 RegulationofChronicInflammationbyControlofMacrophage ActivationandPolarization. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 JunkoSasakiandTakehikoSasaki 9 ClarificationoftheMolecularMechanismsThatNegatively RegulateInflammatoryResponses. . . . . . . . . . . . . . . . . . . . . . . . . 109 TakashiTanaka vii viii Contents 10 TheDrosophilaTollPathway:AModelofInnateImmuneSignalling ActivatedbyEndogenousLigands. . . . . . . . . . . . . . . . . . . . . . . . . 119 TakayukiKuraishi,HirotakaKanoh,YoshikiMomiuchi,Hiroyuki Kenmoku,andShoichiroKurata PartII ImagingAnalysesofChronicInflammation 11 MacrophageDynamicsDuringBoneResorptionandChronic Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 JunichiKikuta,KeizoNishikawa,andMasaruIshii 12 VisualizationofLocalizedCellularSignallingMediatorsinTissues byImagingMassSpectrometry. . . . . . . . . . . . . . . . . . . . . . . . . . . 147 YukiSugiura,KuraraHonda,andMakotoSuematsu 13 TrackingofFollicularTCellDynamicsDuringImmuneResponses andInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161 TakaharuOkada PartIII ChronicInflammationandCancer 14 TheRoleofChronicInflammationinthePromotionofGastric Tumourigenesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 HirokoOshima,KanaeEchizen,YusukeMaeda,andMasanobuOshima 15 CellularSenescenceasaNovelMechanismofChronicInflammation andCancerProgression. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 NaokoOhtani 16 EstablishmentofDiagnosisforEarlyMetastasis. . . . . . . . . . . . . . . 201 SachieHiratsuka 17 Non-autonomousTumorProgressionbyOncogenic Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 ShizueOhsawaandTatsushiIgaki 18 Inflammation-AssociatedCarcinogenesisMediatedbythe ImpairmentofmicroRNAFunctionintheGastroenterological Organs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 MotoyukiOtsuka 19 RolesofEpstein–BarrVirusMicroRNAsinEpstein–Barr Virus-AssociatedMalignancies. . . . . . . . . . . . . . . . . . . . . . . . . . . . 235 AiKotani PartIV ChronicInflammationandObesity/EnvironmentalStress 20 ChronicityofImmuneAbnormalityinAtopicDermatitis: InteractingSurfaceBetweenEnvironmentandImmuneSystem. . . 249 TakanoriHidaka,EriH.Kobayashi,andMasayukiYamamoto Contents ix 21 RoleofDouble-StrandedRNAPathwaysinImmunometabolism inObesity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 TakahisaNakamura 22 MolecularMechanismsUnderlyingObesity-InducedChronic Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291 TakayoshiSuganami,MiyakoTanaka,andYoshihiroOgawa 23 RolesofMitochondrialSensingandStressResponseinthe RegulationofInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 KohsukeTakeda,DaichiSadatomi,andSusumuTanimura 24 OxidativeStressRegulationbyReactiveCysteinePersulfides inInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309 TomohiroSawa PartV ChronicInflammationandInnateImmunity 25 PosttranscriptionalRegulationofCytokinemRNAControlsthe InitiationandResolutionofInflammation. . . . . . . . . . . . . . . . . . . 319 OsamuTakeuchi 26 RolesofC-TypeLectinReceptorsinInflammatoryResponses. . . . 333 ShinobuSaijo 27 ElucidationandControloftheMechanismsUnderlyingChronic InflammationMediatedbyInvariantNaturalKillerTCells. . . . .. 345 HiroshiWatarai 28 UnderstandingoftheRoleofPlasmacytoidDendriticCellsinthe ControlofInflammationandT-CellImmunity. . . . . . . . . . . . . . . . 357 KatsuakiSato 29 MechanismsofLysosomalExocytosisbyImmuneCells. . . . . . . . . 369 Ji-hoonSongandRikinariHanayama 30 PotentialTherapeuticNaturalProductsfortheTreatmentof Obesity-AssociatedChronicInflammationbyTargetingTLRsand Inflammasomes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379 YoshinoriNagai,HiroeHonda,YasuharuWatanabe, andKiyoshiTakatsu PartVI ChronicInflammationandAdaptiveImmunity 31 HumanandMouseMemory-TypePathogenicTh2(Tpath2)Cellsin AirwayInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401 YusukeEndo,KiyoshiHirahara,KentaShinoda,TomohisaIinuma, HeizaburoYamamoto,ShinichiroMotohashi,YoshitakaOkamoto, andToshinoriNakayama x Contents 32 ControllingtheMechanismUnderlyingChronicInflammation ThroughtheEpigeneticModulationofCD4TCellSenescence. . . 417 MasakatsuYamashita,MakotoKuwahara,JunpeiSuzuki, andTakeshiYamada 33 AdrenergicControlofLymphocyteDynamicsandInflammation. . . 429 KazuhiroSuzuki 34 TheMultifacetedRoleofPD-1inHealthandDisease. . . . . . . . . . . 441 MohamedElSherifGadelhaqBadr,KikumiHata,MasaeFuruhata, HirokoToyota,andTadashiYokosuka 35 TheRoleofLysophospholipidsinImmuneCellTraffickingand Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 459 MasayukiMiyasaka,AkiraTakeda,ErinaHata,NaokoSasaki, EijiUmemoto,andSirpaJalkanen PartVII ChronicInflammationandAutoimmuneDiseases 36 DevisingNovelMethodstoControlChronicInflammationVia RegulatoryTCells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 475 JamesB.Wing,AtsushiTanaka,andShimonSakaguchi 37 ControlofChronicInflammationThroughElucidationof Organ-SpecificAutoimmuneDiseaseMechanisms. . . . . . . . . . . . . 489 MitsuruMatsumoto 38 LysophosphatidylserineasanInflammatoryMediator. . . . . . . . . . 501 KumikoMakide,AsukaInoue,andJunkenAoki 39 AberrantActivationofRIG-I–LikeReceptorsandAutoimmune Diseases. . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . .. . . . . 511 HirokiKatoandTakashiFujita 40 ElucidationoftheExacerbationMechanismofAutoimmune DiseasesCausedbyDisruptionoftheIonHomeostasis. . . . . . . . . . 525 MasatsuguOh-hora PartVIII ChronicInflammationandAgeing 41 PathophysiologicalRoleofChronicInflammationinAgeing- AssociatedDiseases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 541 YuichiIkeda,HiroshiAkazawa,andIsseiKomuro 42 UterineCellularSenescenceintheMouseModelofPreterm Birth. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 555 YasushiHirota
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