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Chinese and Botanical Medicines Chinese and Botanical Medicines Traditional Uses and Modern Scientific Approaches Raymond Cooper Chun-Tao Che Daniel Kam-Wah Mok and Charmaine Wing-Yee Tsang CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2018 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper International Standard Book Number-13: 978-1-4822-5758-8 (Hardback) This book contains information obtained from authentic and highly regarded sources. Reason- able efforts have been made to publish reliable data and information, but the author and pub- lisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, repro- duced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www. copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organi- zation that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Names: Cooper, Raymond, author. | Che, Chun-Tao, author. | Mok, Daniel, author. | Tsang, Charmaine, author. Title: Chinese and botanical medicines : traditional uses and modern scientific approaches / Raymond Cooper, Chun-Tao Che, Daniel Mok and Charmaine Tsang. Description: Boca Raton : CRC Press, [2017] | Includes bibliographical references and index. Identifiers: LCCN 2017025433| ISBN 9781482257588 (hardback : alk. paper) | ISBN 9781315118956 (ebook) Subjects: LCSH: Medicine, Chinese. | Materia medica, Vegetable. | Herbs--Therapeutic use. Classification: LCC R601 .C66 2017 | DDC 610.951--dc23 LC record available at https://lccn.loc.gov/2017025433 Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents Foreword ................................................................................................ix Acknowledgment ..................................................................................xi Authors .................................................................................................xiii Chapter 1 Background and content ..................................................1 Book contents ..........................................................................................4 Further suggested reading ....................................................................6 Chapter 2 The beginning of TCM in China and TCM herbalism ............................................................................7 Classical TCM herbal literature ............................................................7 Botanical classification of TCM herbs ...............................................12 Identification of medicinal plants .......................................................15 Medicinal botany...................................................................................16 TCM preparations .................................................................................17 Internationalization of TCM ................................................................18 Further suggested reading ..................................................................20 Chapter 3 TCM theory and practice ...............................................21 Introduction ...........................................................................................21 What is Chinese medicine? ..................................................................21 Initiation of a theoretical system of Chinese medicine ....................21 Traditional categorization ...................................................................22 Cardinal characteristics of Chinese medicine ..................................23 Yin and yang theory and application to Chinese medicine ............25 Characteristics of yin and yang ...........................................................25 Wax and wane and transformation of yin–yang ..............................26 Summary of application of yin– yang theory in Chinese medicine ..............................................................................................26 The five elements ..................................................................................26 The meaning of qi, blood, body fluids, and essence ........................30 v vi Contents Function of qi ........................................................................................30 Therapeutic modalities ........................................................................30 Herbology ..........................................................................................31 Acupuncture ......................................................................................31 Moxibustion .......................................................................................31 Cupping ..............................................................................................31 Exercise therapy ................................................................................31 Dietary therapy ................................................................................32 Medical massage (Tui-Na) and manipulation ..............................32 Bone setting ......................................................................................32 Diagnosis ...............................................................................................32 Palpation ................................................................................................36 Pulse examination ................................................................................36 Location of pulse ..............................................................................37 An example of a diagnosis .............................................................37 Further suggested reading ..................................................................39 Chapter 4 Traditional Chinese medicinal herbs ..........................41 Herbal drug character and property .................................................42 Herbal formulas ....................................................................................44 TCM dietary therapy ...........................................................................49 Biologically active ingredients from TCM herbs .............................50 Future prospects ....................................................................................51 Further suggested reading ..................................................................52 Chapter 5 Examples of TCM formulas used in Chinese medicine ............................................................................53 Herbal medicine ...................................................................................53 Efficacy of TCM ....................................................................................55 Some examples of complex formulas used in TCM ........................55 Danggui-Buxue-Tang .............................................................................63 Four Gentlemen Decoction (Si Jun Zi Tang) ......................................64 Suan Zao Ren Tang (Sour Jujube Decoction) ......................................65 Further suggested reading ..................................................................66 Bibliography ...........................................................................................67 Chapter 6 Examples of single Chinese and botanical medicines derived from TCM ......................................69 Introduction ..........................................................................................69 Evidence-based approach....................................................................70 Contents vii Artemisinin: A Chinese miracle drug ...............................................70 Malaria ..............................................................................................70 Ginkgo ...................................................................................................73 Ginseng ..................................................................................................75 Introduction ......................................................................................75 Ginsenoside variation and standardization .................................75 Ratio of Rg1 and Rb1 and the yin and the yang ..........................75 Adaptogen and effects on exercise performance ........................77 Green tea ................................................................................................78 Introduction ......................................................................................78 Anticancer mechanisms of action .................................................79 Inhibition of NADH oxidase activity ............................................79 Chinese Cordyceps: Winter Worm, Summer Grass ........................80 Introduction ......................................................................................80 Life cycle of Cordyceps sinensis .........................................................81 Perceived health benefits .................................................................82 Salvia (Danshen) ...................................................................................83 Red yeast rice, Monascus purpureus ....................................................87 Dong quai, Angelica sinensis ................................................................88 Garlic ......................................................................................................89 Use of garlic in cardiovascular disease models ...........................90 Ephedra, Ephedra sinica ........................................................................92 Further suggested reading ..................................................................94 Suggested reading on Ginkgo ............................................................94 Suggested reading on Ginseng ...........................................................94 Suggested reading on Green tea ........................................................94 Suggested reading on Cordyceps .......................................................95 Suggested reading on Salvia ...............................................................95 Suggested reading on Garlic ...............................................................95 Chapter 7 TCM safety and regulations .........................................97 TCM safety concerns ...........................................................................97 Toxic compounds and contaminants in TCM herbs .......................98 Aristolochia and Asarum species ..........................................................98 The toxic Aconitum plants ...................................................................103 Datura metel L. ......................................................................................105 Xanthium sibiricum poisoning ............................................................106 Chinese medicinal products ..............................................................107 Po Chai Pills .....................................................................................107 PC-SPES ............................................................................................108 viii Contents Further suggested reading .................................................................111 Bibliography .........................................................................................111 Chapter 8 The current use of TCM in China, Hong Kong, and Southeast Asia .......................................................113 China .....................................................................................................113 TCM regulation in China ...................................................................114 Class 1 to class 9 drugs in China ......................................................114 Malaysia ................................................................................................116 Singapore ..............................................................................................117 Indonesia ..............................................................................................117 Australia ...............................................................................................117 Hong Kong ...........................................................................................118 TCM as part of the medical system in Hong Kong ....................119 TCM trading in Hong Kong ..........................................................120 TCM education in Hong Kong .....................................................122 TCM regulations in Hong Kong ..................................................123 TCM monographs ..........................................................................123 TCM in Hong Kong: Present and future ....................................123 Further suggested reading .................................................................124 Chapter 9 Global acceptance of TCM ..........................................125 Acceptance of TCM in the world .....................................................125 Resurgence of consumer interest: A need for better science in botanical preparations ..................................................................128 TCM needs TQM .................................................................................129 Further suggested reading .................................................................131 Appendix: Plant names .....................................................................133 Glossary of terms ................................................................................137 Bibliography .........................................................................................141 Index......................................................................................................143 Foreword Chinese Medicine has been around for several thousand years. The early discoveries were necessarily empirical. Shen-Long was recognized as the “god” of agriculture and medicine for his fear- less trials of hundreds of herbs and the systematic characterization of their clinical properties. Eventually, when written records were gathered, there were numerous physicians who had contributed to the advances of Chinese Medicine. Today, the international “norm” of clinical medicine is clearly that of Western medicine. It has taken advantage of modern science and technology and incorporated the findings into medical applications. In this manner, Western science and medicine were able to coevolve over the past 200 years. Chinese Medicine, on the other hand, has been relatively slow in exploiting these scientific and technological advances due to the difficulties of integrating these modern advances into the principles of Chinese Medicine, which were firmly established in the “ pre-scientific” era. Nevertheless, Chinese Medicine plays a major role in the health- care industry in China and other Chinese-speaking countries and communities. In addition, Chinese medicine is making inroads into the non-Chinese-speaking communities in the Western and other countries. However, the impact remains understandably limited due to the absence of proper translation of Chinese medicinal con- cepts into many other languages. In this day and age, it seems logi- cal to start with English, which is generally accepted as the “default” language of internationalization and globalization. I must therefore applaud the effort of the authors of this book. This welcome book, titled Chinese and Botanical Medicines: Traditional Uses and Modern Scientific Approaches, provides an elementary framework of Chinese Medicine for the non-Chinese-speaking public. It will also serve as a simple reference book for Chinese Medicine practitioners to take up the further role, in addition to ix

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Chinese and Botanical Medicines: Traditional Uses and Modern Scientific Approaches is a classroom-tested book that contains a balance of chemistry, the history of Traditional Chinese Medicine (TCM), and the theory and practice of a modern TCM practitioner. This distinct book reviews the scientific m
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