Chemokines in Allergic Disease PDF
01999·0.284 MB·English
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Supplies more than 2200 references to encourage ongoing research! This one-of-a-kind volume synthesizes the latest breakthroughs in the fields of allergy and chemokines resulting in innovative paradigms and new concepts concerning the origin and treatment of allergic diseases. Considers the biological properties of nearly 60 structurally related chemokines and over a dozen receptors! Fashioned to give an up-to-date overview of molecular structure, gene regulation, biological properties, and signal transduction pathways, Chemokines in Allergic Disease ·documents the emergence of chemokines as an important super family of chemoattractant cytokines that promote the activation and development of leukocytes ·illuminates the processes that control leukocyte accumulation ·links chemokines with cell recruitment and activation in allergic disease ·explores the benefits of pharmaceutical intervention in the chemokine pathway ·covers the fundamental biochemistry, molecular biology, and physical structure of chemokines and their receptors ·describes transcriptional regulation of chemokine expression ·discusses virally induced gene expression as a main trigger of allergic responses in children ·analyzes eosinophils, basophils, T lymphocytes, dendritic cells, and macrophages ·elucidates the cellular network involved in the generation of chemokines in allergic diseases ·highlights pharmaceutical approaches for the development of chemokine structural analogs, receptor antagonists, and inhibitors of signal transduction ·offers therapeutic strategies for interfering with chemokines in allergic disorders ·and more! With contributions from 46 internationally respected clinicians, Chemokines in Allergic Disease is an indispensable reference for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.
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