Charlotte van Asch v 7.0.indd

187 Pages·2015·4.97 MB·English

Imaging of non-traumatic intracerebral
and intraventricular haemorrhage
Charlotte van Asch
Cover Image Enso with pine tree branch
Cover Design Hans Scheffers, creationstation.nl
Layout Maroesja Swart-Nijhuis, Puur*M Vorm & Idee
Printed by Off Page
ISBN 978-94-6182-626-8
© 2015 C.J.J. van Asch
All rights reserved. No part of this publication may be reproduced, stored in
a retrieval system or transmitted in any form or by any means, electronically,
mechanically, by photocopying, recording or otherwise, without the prior written
permission of the author. The copyright of the articles that have been published, has
been transferred to the respective journals.
Imaging of non-traumatic intracerebral
and intraventricular haemorrhage

Beeldvormend onderzoek van niet-traumatische intracerebrale
en intraventriculaire bloedingen
(met een samenvatting in het Nederlands)
Proefschrift
ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de
rector magnificus, prof.dr. G.J. van der Zwaan, ingevolge het besluit van het college voor
promoties in het openbaar te verdedigen op donderdag 17 december 2015
des ochtends te 10.30 uur
door
Charlotte Judith Johanna van Asch
geboren op 16 maart 1980
te ’s-Hertogenbosch
Promotoren: Prof.dr. G.J.E. Rinkel
Prof.dr. C.J.M. Klijn

Co-promotor: Dr. B.K. Velthuis
The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF-2007B048).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Publication of this thesis was also financially supported by Chipsoft BV, Sectra Benelux, UMC Utrecht Brain
Center Rudolf Magnus, and ABN AMRO.
“Rabbit’s clever,” said Pooh thoughtfully.
“Yes,” said Piglet, “Rabbit’s clever.”
“And he has Brain.”
“Yes,” said Piglet, “Rabbit has Brain.”
There was a long silence.
“I suppose,” said Pooh, “that that’s why he never understands anything.” 
A.A. Milne, The House at Pooh Corner

CONTENTS

List of abbreviations 9
Chapter 1 General introduction 11
PART I: Epidemiology of intracerebral haemorrhage
Chapter 2 Incidence, case fatality, and functional outcome of intracerebral haemorrhage 21
over time, according to age, sex, and ethnic origin: a systematic review and
meta-analysis
PART II: Imaging of intracerebral and intraventricular haemorrhage
Chapter 3 Early intracerebral haematoma expansion after aneurysmal rupture 49
Chapter 4 External validation of the Secondary IntraCerebral Hemorrhage (SICH) score 61
Chapter 5 Diagnostic yield and accuracy of CT angiography, MR angiography and digital 73
subtraction angiography for detection of macrovascular causes of intracerebral
haemorrhage – a prospective, multicentre cohort study
Chapter 6 The optimal diagnostic strategy for non-traumatic intracerebral 99
haemorrhage: a cost-effectiveness analysis
Chapter 7 Yield of angiographic examinations in isolated intraventricular haemorrhage: 129
a case series and systematic review of literature
Chapter 8 General discussion 143
Chapter 9 Summary 159
Samenvatting (Dutch summary) 163
Acknowledgements 171
Dankwoord (Personal Acknowledgements) 175
Curriculum Vitae 183
List of publications 185
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9
LIST OF ABBREVIATIONS
AVM arteriovenous malformation
CT computed tomography
DAVF dural arteriovenous fistula
DSA digital subtraction angiography
DVA developmental venous anomaly
ICH intracerebral haemorrhage
IVH intraventricular haemorrhage
MRA magnetic resonance angiography
MRI magnetic resonance imaging
mRS modified Rankin Scale
NCCT non-contrast computed tomography
SAH subarachnoid haemorrhage
QALY quality-adjusted life year
10