Cercival Cancer: From Etiology to Prevention

431 Pages·2004·41.283 MB·English

by  Mark H. Stoler M.D. (auth.), Thomas E. Rohan M.B.B.S., Ph.D., Keerti V. Shah M.D., Dr.P.H. (eds.)

Cervical Cancer: From Etiology to Prevention
Cancer Prevention - Cancer Causes
Volume2
Cercival Cancer:
From Etiology to Prevention
Edited by
Thomas E. Rohan, M.B.B.S., Ph.D.
Professor Chairman,
Department ofE pidemiology and Population Health,
Albert Einstein College ofM edicine,
Bronx, NewY ork, U.S.A.
and
Keerti V. Shah, M.D., Dr.P.H.
Professor,
Departments ofM olecular Microbiology and Immunology,
Johns Hopkins Bloomberg School ofP ublic Health,
Baltimore, Maryland, U.S.A.
Foreword by Harald zur Hausen, M.D., D.Sc.
Springer-Science+Business Media, B.V.
A C.I.P. Catalogue record for this book is available from the Library of Congress.
Printed on acid-free paper
ISBN 978-90-481-6336-6 ISBN 978-1-4020-2016-2 (eBook)
DOI 10.1007/978-1-4020-2016-2
All Rights Reserved
© 2004 Springer Science+Business Media Dordrecht
Originally published by Kluwer Academic Publishers in 2004.
Softcover reprint of the hardcover 1s t edition 2004
No part of this work may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming, recording
or otherwise, without written permission from the Publisher, with the exception
of any material supplied specifically for the purpose ofbeing entered
and executed on a computer system, for exclusive use by the purchaser of the work.
To Our Wives,
Rosa and F arida
Contents
Contributors ix
Foreword xv
Introduction xxv
SECTION 1 -BIOLOGICAL BASIS 1
1. The Pathology of Cervical Neoplasia 3
Mark H. Stoler, M.D.
2. The Natural History of Cervical Cancer 61
Anthony B. Miller, M.B., F.R.C.P.
SECTION 2-HUMAN PAPILLOMA VIRUS 79
3. The Biology of Human Papillomavirus Infections 81
Patti E. Gravitt, M.S., Ph.D. and Keerti V. Shah, M.D., Dr.P.H
4. The Molecular Pathogenesis of HPV -Associated Cancer 101
Stephen T. Oh, Ph.D. and Laimonis A. Laimins, Ph.D.
V111
5. Measurement of Exposure to Human Papillomaviruses 119
Patti E. Gravitt, M.S., Ph.D. and Raphael P. Viscidi, M.D.
6. The Epidemiology of Human Papillomavirus Infections 143
Rachel L. Winer, M.P.H. and Laura A Koutsky, Ph.D.
SECTION 3 -ETIOLOGY 189
7. The Etiology of Squamous Cell Cervical Cancer 191
F. Xavier Bosch, M.D., M.P.H.
8. The Epidemiology of Adenocarcinoma of the Cervix 217
Thomas E. Rohan, M.B.B.S., Ph.D.
SECTION 4-PREVENTION 235
9. Educational Strategies for the Prevention of Cervical Cancer 237
Electra D. Paskett, Ph.D.,
Mary Ellen Wewers, Ph.D., R.N., M.P.H., and
Mack T. Ruffin IV, M.D., M.P.H.
10. Screening for Cervical Cancer 261
Jack Cuzick, Ph.D.
11. Chemoprevention of Cervical Cancer 301
Michele Pollen, M.D., Ph.D., FrankL. Meyskens, Jr., M.D.,
E. Neely Atkinson, Ph.D., and David Schottenfeld, M.D.
12. Preventive Human Papillomavirus Vaccines 325
John T. Schiller, Ph.D. and Douglas R. Lowy, Ph.D.
13. Therapeutic Human Papillomavirus Vaccines 345
Morris Ling, B.A. and T.-C. Wu, M.D., Ph.D.
14. Policies for Implementing Cervical Cancer Preventive
and Control Strategies 37 7
Robert A. Hiatt, M.D., Ph.D. and Jon F. Kerner, Ph.D.
INDEX 403
Contributors
E. Neely Atkinson, Ph.D.
Department of Biomathematics, The University of Texas M D. Anderson
Cancer Center, Houston, TX
F. Xavier Bosch, M.D., M.P.H.
Servei d'Epidemiologia i Registre del Cancer Institut Catala d'Oncologia,
Barcelona, Spain
Jack Cuzick, Ph.D.
Cancer Research UK , Dept. of Epidemiology, Mathematics and Statistics,
Wolfton Institute ofP reventive Medicine, London, UK
Patti E. Gravitt, M.S., Ph.D.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public
Health, Baltimore, MD
Michele Pollen, M.D., Ph.D.
Center for Biomedical Engineering, The University of Texas MD. Anderson
Cancer Center, Houston, TX
Robert A. Hiatt, M.D., Ph.D.
Division of Cancer Control and Population Sciences, National Cancer
Institute, NIH, Bethesda, MD
IX
X Contributors
Harald zur Hausen, M.D., D.Sc.
Deutsches Krebsforschungszentrum, Heidelberg, Germany
Jon F. Kerner, Ph.D.
Division of Cancer Control and Population Sciences, National Cancer
Institute, NIH, Bethesda, MD
Laura A. Koutsky, Ph.D.
Department ofE pidemiology, University of Washington, Seattle, WA
Laimonis A. Laimins, Ph.D.
Department of Microbiology- Immunology, Feinberg School of Medicine,
Northwestern University, Chicago, IL
Morris Ling, B.A.
Department of Pathology, The Johns Hopkins Medical Institutions,
Baltimore, MD
Douglas R. Lowy, Ph.D.
Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda,
MD
FrankL. Meyskens, Jr., M.D.
Chao Family Comprehensive Cancer Center, University of California
Irvine, Irvine, CA
Anthony B. Miller, M.B., F.R.C.P.
Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum,
Heidelberg, Germany
Stephen T. Oh, Ph.D.
Department of Microbiology- Immunology, Feinberg School of Medicine,
Northwestern University, Chicago, IL
Electra D. Paskett, Ph.D.
School of Public Health/Comprehensive Cancer Center, Ohio State
University, Columbus, OH
Thomas E. Rohan, M.B.B.S., Ph.D.
Department of Epidemiology and Population Health, Albert Einstein
College ofM edicine, Bronx, NY