Table Of Content

ular and Molecular Life Science a's Birkhauser Verlag Basel - Boston - Berlin Scope The multidisciplinary journal Cellular and Molecular Life Sciences publishes research articles, mini-reviews, reviews and multi-author reviews covering the latest aspects of biological and biomedical research. The journal will consider contributions focusing on molecular and cellular aspects of biomedicine, cell biology, immunology, molecular genetics, neuroscience, biochemistry, pharmacology, and physiology related to pharmacology. Editor-in-Chief Editorial Board Professor Dr. Pierre Jollés Johannes Boonstra, Utrecht Muséum National d’ Histoire Naturelle Kenneth J. Clemetson, Bern Laboratoire de Chimie Ferdinand Hucho, Berlin 63, rue Buffon Hans Jérnvall, Stockholm F-75005 Paris / France Isabelle Mansuy, Ziirich and Robert I. Norman, Leicester Systemes moléculaires/Biologie structurale Lorenzo A. Pinna, Padova Université Paris 6 David D. Roberts, Bethesda, MD Tour 16, case 115 Pal Venetianer, Szeged 4, place Jussieu Walter Wahli, Lausanne F-75005 Paris / France Timothy E. Weaver, Cincinnati, OH Tel.: +33-1-40 79 38 95 and +33-1-44 27 50 72 Advisory Board Fax: +33-1-40 79 31 22 e-mail: [email protected] Ernest Arenas, Stockholm Jesus Avila, Madrid Isabelle Callebaut, Paris Editorial Office Rowen J.-Y. Chang, Houston, TX Frank O. Fackelmayer, Hamburg Renate Holliger, Lucette Oggier, Michelle Killenberger Roser Gonzalez-Duarte, Barcelona Dr. Johannes Korn (Scientific Assistant) Lukas A. Huber, Innsbruck CMLS Marie-Helene Metz-Boutigue, Strasbourg Birkhauser Verlag Peter J. Neame, Tampa, FL P.O. Box 133 Michael J. Parnham, Zagreb CH-4010 Basel / Switzerland Jean-Marie Ruysschaert, Bruxelles Jirina Slaninova, Praha Tel. +41 61 205 07 68 Naoyuki Taniguchi, Osaka Fax +41 61 205 07 95 Alan J. Wolfe, Maywood, II e-mail: cmlsedit(@birkhauser.ch Visit our Web site http://www.birkhauser.ch Subject Index 1 1 B-Hydroxysteroid Amyloid B-protein 1538 Atomistic simulation 207 dehydrogenase 565 Amyloid peptides 2432 Atopic dermatitis 469 2-Arachidonoyi glycerol 1410 Amyloid precursor protein 1226 ATP 1494 2-Hydroxyfatty acids 1553 Amyloidogenesis 1677 ATPase 2571 5’ untranslated region 1780 Anandamide 1410 ATPase activity 1912 Anatomy 1106 Auxin transport 2738 a-actinin 25 Androgen receptor 487 AVA 2237 a-oxidation 1752 Aneuploid neuron 2626 Avidin 2992 A site 2725 Aneuploidy 112 Azurocidin/heparin binding protein AAA’-ATPase 890 Angiogenesis 449, 565, 601, 2067, CAP37 2405 AAA-TOB3 2162 2435, 2695, 3083 ABC transporter 653, 1912, 2908 Anoikis 755 B-adrenergic receptors 1070 Abl 2818 Anosmin-| 2512 B-amyloid 1226 Abscisic acid 229] Antennal lobes 989 B-Catenins 2016 Accuracy of protein synthesis 2725 Anthracis 2237 B-defensin structure 1294 Acetylcholine 2039 Anthrax 2196, 2237 B-jelly roll fold 2954 ACTAI 723 Anti-amyloidognic therapy 1538 B-oxidation 2415 i Actin cytoskeleton 25, 235 Anti-cancer 235 B-roll 2804 Actin filament dynamics 2 I 19 Anti-cancer chemotherapy 1912 B-sandwich 2954 Actin 220, 2329 Anti-cancer drugs 2119 B-thalassemia 3018 ACTN4 2506 Anticoagulant therapy 2773 BACE1 877 Adaptor 1823 Antiepileptic drugs 399 Bacterial resuscitation 2555 Addiction 1597 Antigen processing 653 BAD 2377 Adenosine 2527 Antimicrobial and chemotactic Bardet-Biedl syndrome 2145 Adenosine A, receptor 2427 activity 1294 Bartter syndrome 1962 Adenosine A,, receptor 2427 Antimicrobial peptides 469, 1060, Base flipping 1266 Adenylate kinase 2829 3072 Bel-2 family 60 Adenylyl cyclase 1736 Antimicrobial proteins 469 BCO (beta-carotene cleavage Adherence 2352 Antimutator 123 oxygenase) 229] Adhesin 1331 Antioxidant capacity 414 BCR/ABL 2939 Adhesion 82, 2979 Antiquitin 2881 Beriberi 1553 Adhesion molecule 498 Antisense RNA 2102 Bestrophin 12 Adipocytes 616, 1386 Antitumor activity 229 Betaine 2792 AdoMet 2183 Antizyme 2095 Betaine homocysteine ADP 890 Antizyme inhibitor 2095 methyltransferase 2792 Affinity 2992 Apical sorting 249] Biogenesis 1686 Aggregation 1899, 2642 Aplysia 963, 1009 Bioinformatics 246 AIDS 163 Apo-carotenoid 2291 Bionanotechnology 2992 Akt 1632, 2871 Apolipoprotein A-I 2829 Bioterrorism 2196, 2213, 2223, Aldehyde dehydrogenase 2881 Apolipoprotein L (apoL) 1937 2229 Aldosterone 1962 Apoptosis 60, 220, 229, 399, 686, Biotin carboxylase 843 Allergen 1091 949, 1410, 1425, 2162, 2377, Biotin 2992 Allergenicity 109] 2415, 2527, 2538, 2661, 3061 Bitter taste receptor 1501 Aloe-emodin 3083 AQP3 1386 BK virus (BKV) 865 Alpha-aminoadipic AQP7 1386 Blisters 1193 semialdehyde 2881 Aquaporin 1386 Blood coagulation 1024, 3030 Alpha-fetoprotein 2922 Arabidopsis 698, 2738 Blood-brain barrier 1614 Alternative polyadenylation 796 Artemisinins 1586 Blue-light reactions 1266 Alternative splicing 723, 796 Artificial life 1278 Bone marrow 1649 Alzheimer’s disease 1226, 1538, ASCT-2 1906 Bosd3 1091 2626 Associative learning 1597 Botulinum toxin 540 AMIC 616 Astrocytes 843 Botulism 2196 AMIDA 2162 Asymmetric dimethylarginine 2838 Brain 961, 1106 Amino acid deprivation 1813 Asymmetric division 760 Brain serotonin 6 Amino acid sequence 3042 Asymmetry 672 Breast cancer 1906 Aminoacylation 820, 1813 Ataxia telangiectasia 2626 Breast cancer resistance AMPK 1393 Ataxin-3 1677 protein 1912 Amygdala 999, 1597 ATF4 1632 Breast carcinoma 2016 Amylase 2710 Atherosclerosis 524, 2079, 3018 Brownian dynamics 301 Brucella 2229 Cellular conversion factors 2342 Consolidation 999 Brucellosis 2229 Cellular memory 2249 Contraction 82 Buried water 207 Centrosomes 2145 Cortex 1597 Butaprost 2546 Ceramide 1017 Coupling of RNA processing to Cerebellar granular neurons 2859 transcription 796 C. elegans 1193 CFTR 12 COX-2 1024 C/EBP 999 Chain termination 163 CREB 999 Ca’ activation 12 Channels 36 CREB-binding protein (CBP) 1725 Ca’ binding 2804 Chaperone 207, 378, 939, 2560, Cre-LoxP system 767 Cadherin gene superfamily 1564 2889 Creutzfeldt-Jakob disease 2342 CAG expansion 2642 Checkpoint 781 Cross-linker 229 Calcineurin 333, 1236 Chelicerata 2477 Culture conditions 919 Calcium 333, 1236, 1440 Chemical chaperone therapy 1179 Cyclic cystine knot (CCK) 235 Calcium channel 301 Chemical coding 1510 Cyclin Al 1425 Calcium signaling 2387 Chemical communication 1658 Cyclin BI 112, 2538 Calmodulin 1236, 1945 Chemical discrimination 1510 Cyclin-dependent kinase Calpain 949 Chemical modification 235 inhibitors 2397 cAMP 92, 1736, 2546 Chemokine 2079 Cyclobutane-pyrimidine dimer cAMP-responsive element binding Chemoreceptor genes 1510 (CPD) 1266 protein (CREB) 1725 Chemosensory proteins 1658 Cyclophilin (Cyp) 2889 Cancer 268, 1024, 1823, 2175, Chemotaxis 2304 Cyclotide 235 2095, 2626, 2661, 2968, 3083 ChIP-chip 2260 Cytochrome c maturation 1642 Cancer predisposition 2135 Chitotriosidase 3018 Cytokinesis 112 Cannabidiol 2057 Chloroplast 698 Cytosine methylation function 1933 Cannabinoid 1410, 1597 Cholesterol 1038, 2829 Cytoskeleton 82, 1945, 2491, 2979 Capping 796, 2119 Cholinesterases 2175 Cytotoxic 235 Carbohydrate-binding module 2954 Chondrocytes 616 Cytotoxic compound 2119 Carbohydrate-binding module Chondrogenesis 2435 families 2710 Choroid plexus 1614 Database exactitude 517 Carbonyl reductase 1205 Chromaffin cells 2818 Deafness 2329 Carcinogenesis 686 Chromatin 144, 316, 1009 Decapping 123 Cardiac development 1141 Chromatin modifications 2755 Defensin 3072 Cardiac myocytes 1070 Chromosome 1125 Deimination 1945 Cardiomyoblasts 3061 Chromosome loss and gain 2626 Dent’s disease 367 Cardiovascular disease 524, 565 Chronic obstructive pulmonary Desert Hedgehog 642 Cardiovascular system 1070 disorder 540 Design principles 1215 Carotenoid cleavage 229] Chronic pancreatitis 642 Detoxification 2881 Cartilage 616, 2435 Ci/Gli transcription factor 1249 Development 187, 399, 1249, 1933, Casein kinase 378 Cilia 2145 2317 Caspase 60, 949, 2057 Classification 2954 Diabetes 2317 Catabolism 2405, 2432 Clathrin 1823 Diabetes mellitus 524 Catalysis 1736 Claudin-5 505 Diabetes type | 1805 Catalytic RNA 1278 CIC 12, 301 Dicarbonyl compounds 1205 Caveolin 939 Cleaved uPAR 1028 Differentiation 760, 1649 CBM clan 2710 Clinical trials 755 Dimerization 505 CemG 1642 c-myc 2377 Dimethylarginine CDid 1889 CNGA2 channel 1476 dimethylaminohydrolase 2838 Cde2 112 CNT2 2527 Dioxygenases 229] Cdc42 82 Coenzyme 890 Direct thrombin inhibitor 2773 cdki 1425 Cofactor 2304 Disaster planning CDKI 2538 Collecting duct 367 Distribution 2792 CDK2 2538 Colorectal carcinoma 663 Disulfide isomerization 1642 Cell adhesion molecule 1833, 2079 Combination therapy 832 Diuresis 2477 Cell cycle 112, 229, 2183, 2397 Conditioning 975 DNA binding specificity 487 Cell cycle progression 220 Conformational disease 709 DNA damage 781 Cell migration 25 Conformational flexibility 2608 DNA methylation 1933 Cell penetrating peptide 627 Congenic mice 6 DNA regulation 59] Cell proliferation 2387 Congenital general anosmia 1485 DNA repair 1266 Cell therapy 2764 CongeoOn ital heart defects 1141 DNA synthesis 163 Cell-permeable peptide 2682 Congenital muscular dystrophy 52 DnaJ 2560 Cell-specific 144 Conivaptan 1766 DNA-photolyase 1266 Cellular compartments 2432 Connexin 1125 DNA-protein interaction 2571 Dopamine 187, 1597 EPAC 92 Fusion 1906 Dormancy 2555 Epidermal growth factor Fusion protein 540 Dorsal stream hypothesis 1867 receptor 930 Double-stranded RNA 2102 Epidermis 1386 G protein signalling Down syndrome 2626 Epigenetics 144 Gl arrest 2538 Doxycycline 949 Epithelial cells 1614, 2491 Gl phase 220 Dp71 1614 Epithelium 686 GADD45 2377 Drosophila 975, 989, 1701, 2027, ERKs 637, 963 Galectin-7 686 2477 Espin 2329 Gamma delta T cell 2089 Drosophila melanogaster 1933 Ethanol 2039 Gamma delta T cell receptor 2089 Drug 163 Ets 2460 Gamma delta T cell receptor Drug candidate 2773 Europe 2223 structure 2089 Drug discovery 2608 Evolution 343, 1125, 1579 Gap junction 1125, 2079 Drug resistance 1706 Evolutionary relatedness 2710 GAT-1 190 Drug target 855 Expression 2027 GATA-1 2460 Drug transport 1038 Expression pattern 3072 Gaucher’s disease 3018 DsbC 1642 Extracellular matrix 616 Gene annotation 517 DsbD 1642 Gene expression 919, 1933, 2183 DsbG 1642 Facilitation 963 Gene regulation 92, 144 dsRNA 901 Familial focal segmental Gene targeting 60 dsRNA Bacteriophage 1095 glomerulosclerosis 2506 Gene therapy 1179 Dual-family immunophilin 2889 Familial nephropathy 2506 Gene transcription 2260 Dynamin 1823 Family 1.3 lipase 2804 Genetics 1141, 2506 Dystrophin 1614 Farnesylation 1686 Genome packaging 1095 Fatty acid metabolism 2847 Genomic paralogy 1564 E site 2725 Fed-fasting transition 358 Genomics 796 E. coli 540 FENIB 709 Germ cell clusters 579 ES oncoprotein 930 Ferredoxin 855 Germinal centre 498 EC number 517 Ferritin 59] Gitelman syndrome 1962 E-cadherins 2016 Fertility 2886 Glia 1649 Editing 796 Fetal alcohol syndrome 2039, 2859 Glioma cells 2057 eEFSec 73 FGF 2435 Glucocerebrosidase 1179 Egg case silk 1986 FGFRI 2512 Glucocorticoid 60 FHL2 268 Glucose-induced insulin Fibrate 1165 secretion 843 22 Fibrillation 3 ee Glucosidase II 1923 Fibrin 1024 Glucosylceramide 1179 Electron transfer 855, 1266 Fibroblast 82 Glutamate synthesis 843 Electrophysiology 100 Fibroin 1986 Glutamatergic Electrospray ionization mass Filament stabilization 2119 neurotransmission 2427 spectrometry 1805 Filamin 939 Glutamine synthetase 2922 Embryo 672 FK506-binding protein Glycerone 890 Embryo implantation 2695 (FK506) 2889 Glyceroneogenesis 843 Embryonic stem cell 760 Flagellin 2352 Glycogen synthase kinase 38 1226 Emerging infectious diseases 2213 Flavodoxin 855 Glycolipid 1889 Emerin 2702 Flavonoids 2847 Glycosylphosphatidylinositol 2175 Emery-Dreifuss muscular Flexibility 207 GnRH 2512 dystrophy 2702 Fli-1 2460 Golgi apparatus 378, 1923 Emodin 3083 FLNC 723 Gordon syndrome 1962 Emotional processing 1597 Flotillin 343 GPCR 1149, 1579 Endocytosis 367, 1819, 1823 fMLP receptor 1028 G-protein coupled receptors Endoderm 672 FNR 855 (GPCRs) 1501, 1969, 2000, 2695 Endogenous expression 1969 Folding 939 Gramicidin 301 Endogenous ligand 2901 Folliculogenesis 579 Grueneberg ganglion 1465 Endomannosidase 1923 Food 1876 GSK-3fB 2871 Endoplasmic reticulum 2027 Forebrain 187 GTPase 2446 Endothelial cell 601, 1614, 1906 Forskolin 2546 Gustatory system 1501 Endothelial nitric oxide FP prostanoid receptor 112 Gut 2175 synthase 144 Frameshift 2725 EwnEdIMoAVtUhLIeN liUuEm 144, 1070 FRAP 735 H/D exchange 285 Enzyme mechanism 2571 Frog skin secretion 1060 Haemostasis 1024 Enzyme replacement therapy 1179 Function 1106 Haemostasis and thrombosis 1085 Hair cell 2329 Hypertrophy 333 Josephin 1677 Hairpin 901 Hypoxia-reoxygenation 3061 Junction 2979 Heart tissues 2584 Heat shock 2560 IEC-6 2871 Kallikrein 2886 Hedgehog 435, 642, 663 IGF 1701 Kallmann 2512 Hedgehog signaling 1249 IGF-1 receptor 3055 Keratinocytes 469 Helicobacter pylori 855 IGF-binding protein-1 2405 KIAA1273 2162 Hemiaminal 890 IL-8 2352 Kidney 1614, 2506 Hep27 1205 ILK 25 Kidney stones 367 Heparan sulfate 2435 Immunity 1017, 3018 Kinase 552, 1249 Heparan sulfate proteoglycan 1819 Immunocytochemistry 2364 Kinase structure 2608 Heparin 2067 Immunoglobulin fold 2954 Kinetic stability 1899 Hepatic gene transcription 1393 Immunohistochemistry 2364 Kinetics 257] Hepatic insulin resistance 1393 Immunology 1331 Knockout mouse 12 Hepatic steatosis 1393 Immunophilin 2889 Hepatocyte 2829 Immunotoxin 1850 Hepatocyte growth factor 2016 Indian Hedgehog 642 HepG2 2838 Indole-3-carbinol 2661 Hereditary 2506 Indoleacetic acid 2738 Lamin A 2702 Heteromeric receptor 2427 Indolylalkylamines 1440 Laminopathies 2702 Hexameric helicase 1095 Infection control 2213 L-arginine 2838 Hidden knowledge 517 Infectious disease 1060, 1331 Latrodectus hesperus 1986 High-density lipoprotein Infectivity 1017 Learning 961, 1009 (HDL) 2829 Inflammation 565, 1017 Learning and memory 975 Hippocampus 999, 1009, 2818 Inhibitors 1912, 2968 Lectin 1331, 1850 Hirudin 2773 Innate and adaptive immunity Leukaemogenesis 2939 Histone 1009 1294 Leukocyte recruitment 2079 Histone acetyltransferase Innate immunity 469, 1060, 1937 Liddle syndrome 1962 (HAT) 1725 Inositol pyrophosphates 552 Ligand recognition 2089 Histone code 144 Insects 1579, 1658 Limited proteolysis 3042 Histone deacetylase inhibitor Insulin 939, 1701, 2432 LIMKI 1867 (HDAC) 1725 Insulin disaggregation 1805 LINE 1449 Histone lysine methylation 2755 Insulin effect 1805 Lipase 207, 1355 HIV-1 163 Insulin hexamer decrease 1805 Lipid flip-flop 2908 HIV-TAT 1819 Insulin receptor 3055 Lipid particle 1355 HLA-G 2669 Insulin resistance 2039 Lipid rafts 343, 1038 - hnRNP 796 Insulin/C-peptide segment 3055 Lipid storage 13 5 Homeostasis 1614 Insulin-like growth factor 2039, Lipid traffic 1038 Homocysteine 2792 2405 Lipid translocase 1038 Honeybee 989 Integrins 601, 1028 Lipid vesicle 1945 Hormone-refractory prostate Interacting proteins 268, 1969 Lipid-peptide interaction 1060 cancer 487 Interferon-alpha 2387 Lipids 36 Hormones 2477 Intermyofibrillar mitochondria 358 Lipogenesis 843 Hospital preparedness 2213 Intestinal microflora 2352 Lithium 1226 Housecleaning 123 Intestinal mucosal Liver 2527 Housefly (Musca domestica) homeostasis 2901 Liver development 2922 3072 Intracellular oscillator 1215 Liver X receptor 524 Hsp40 2560 Intracellular trafficking 2145 Lixivaptan 1766 Hsp70 2560 Intracellular transport 2642 LKBI 2135 Human 92 Intraflagellar transport 2145 Localization 901 Human f-defensin 1294 Intrinsically unstructured 1945 Long-term memory 1725 Human cancer 1314 Invasion 2352 Loop of Henle 1962 Human disorder 1165 Invasive growth 1024 LTP 1009 Human immunodeficiency lon channels 301, 2000 Lymphangiogenesis 449 virus 1706 Iron 59] Lymphocytic leukemia cells Human lymphoma cell line 235 Islets of Langerhans 642 2538 Human papillomavirus 930 Isoforms 2027 Lymphoid tissue 498 Human tumors 755 lsoprenylation 255 Lysin 1899 Humoral responses 2249 Isoproterenol 2546 Lysophosphatidic acid 2695 Hydration 285 Lysosomal hydrolase 1179 Hydrogen 285 JAK2 2939 Lysosome 1937 Hydrogen bond 285 JC virus (JCV) 865 Lysyl oxidase 2304 Macrophages 524 Mitochondria 414, 698, 949, 1440, Neuropeptides 2477 Magnetic resonance imaging 1780, 2415 Neuropilin 601, 2067 (MRI) 1106 Mitochondrial efficiency 358 Neuroprotection 1410 Magnetic resonance spectroscopy Mitochondrial protein 2162 Neurotoxin 3030 (MRS) 1106 Mitochondrial respiratory Neurotransmitter transporter 100 Main olfactory epithelium 1476 chain 1236 Neurotrophin 1523 Main olfactory system 1465 Mitosis 781, 1823 Neutral Pl moiety 2773 Major ampullate gland 1986 Mitotic catastrophe 1425 Neutron diffraction 285 Major histocompatibility Modelling 1876 V-glycosylase 1850 complex 1476 Molecular biology 498 V-glycosylation 1923, 2908 Malaria 1586 Molecular dynamics 301 Niche 760 Malignancy 2304 Molecular evolution 1564 Nicotinic acetylcholine Mammal 1579, 2901 Molecular markers 1586 receptor 2818 Mammary gland 378 Molecular mechanisms 999 Nitric oxide 1070, 2838 MAP kinase 2067 Molecular switch 2446 NKT cell 1889 MAPK 1632, 1701 MOLT-4 cells 2538 Nodal 672 Marine agents 2377 Monoamine oxidase inhibitors 1440 Node 963 Mathematical model 832 Monoclonal antibody 2364 Nogo 877 Matriptase 2968 Monooxygenases 229] Non small cell lung cancer 2377 Matrix metalloproteinase 663 Monotherapy 832 Non-alcoholic steatohepatitis Measles virus 39] Mosaic variegated aneuploidy 2626 3018 Mechanism of toxicity 1370 Mouse models 767 Non-coding RNA 2102 Mefloquine 1586 mRNA 246 Non-cognate trna/amino acid 820 Megakaryocyte 2460 mRNA regulation 59] Non-heme iron proteins 2291 Melanocyte 2364 MT-SP1 2968 Nonvolatile chemosignal 1476 Melanoma 2364, 2661 Multidrug resistance 1038, 1912 NRTI 163 Membrane assembly 2908 Multiple sclerosis 1945 Nuclear envelope 316 Membrane asymmetry 2908 Muscle disorders 52 Nuclear export 1813 Membrane cholesterol 2039 Mushroom bodies 989 Nuclear import 1813 Membrane fusion 249] MuSK 2818 Nuclear pore complex 316 Membrane lysis 1370 Mutagenesis 832, 2992 Nucleoside diphosphokinase 2829 Membrane proteins 1149, 2597 Mutants 975 Nucleoside transporters 2527 Membrane-active peptide 1060 Mutation 487, 1314, 2027 Nucleotide metabolism 123, 2829 Memory 961, 963, 989, 999, 1009, MutT 123 Nudix 123 1410 MyBPC1 723 NUDT 123 Mesenchymal cell 2764 Myelination 2695 Nutrigenomics 2847 Mesenchymal stem cells 616, 1649 Myeloproliferative disorders 2939 Mesoderm 672 Myogenic differentiation 2764 Occludin 505 MET 1024 ODC 2095 Met 2016 Natural ligand 1889 Odorant receptor 1579 Metabolic syndrome 524 Necrosis 229, 3061 Odorant-binding proteins 1658 Metabolism 552, 1106, 1215, 2317 Needs assessment 2223 Olfaction 1579, 1658 Metastasis 435, 449, 755 Nephrin 498, 2506 Olfactory receptors 1485 Methionine biosynthesis 2183 Nephrocalcinosis 367 Oligodendrocyte 1945 Methionine 2792 Neprilysin 1538 Oligomerization 343 Mevalonate pathway 255 Nervous system 709 Oncogene 1024 MFEI 246 Nervous system development 2695 Operon 2260 MHC 2089 Networks 2597 Oral bioavailability 2773 MHC class I 653 Neural 672 Organogenesis 2317 Microarray expression Neurexin 1833 Origin of life 1278 profiling 2260 Neurodegeneration 399, 877 Orphan enzyme 517 Microarray 919, 2847 Neurodegenerative disorders 3018 Osmoregulation 2881 Microdomain 1790 Neurogenesis 1701 Osteoclast 391 MicroRNA 246, 2102 Neurogenetics 975 Osteocytes 616 Microvilli 2329 Neuroimmunology 92 Ovalbumin 627 Midbrain 187 Neuroligin 1833 Oxidative damage 358 Migration 82, 686, 2512, 2871 Neuromuscular junction 2818 Oxidative phosphorylation 1236 Minimal folding free energy Neuron 187, 1523, 1579, 1649, Oxidative stress 414, 2057 index 246 2512 Oxygen 591 Neuronal apoptosis 1226 Misacylation 820 Neuronal death 2397 p21 637 Misfolding diseases 1677 Neuronal differentiation 2764, 2859 p27 2397 p53 1425 PKC isoforms 637 Protein kinase structure 781 ris” 1523 Plant 246, 2446 Protein ligand interaction 855 pl07 767 Plant toxins 1370 Protein nuclear magnetic resonance pl30 767 Plasma membrane 1790 spectroscopy 2608 Pacing 333 Plasmodium falciparum Protein oxidation 2304 Paget’s disease 39] malaria 3018 Protein sequence 517 PAI-1 1024 Platelet activation 1085 Protein structure 540 Pain 540 Platelet aggregation 3030 Protein structure-function Palmitate-induced proton leak 358 Platelets 1070, 2460 mechanism 207 Pancreas development 642 Pleiotropic function 1165 Protein synthesis 999, 2725 Pancreatic cancer 642 PMA 2669 Protein trafficking 2491 Pannexin 1125 Podocin 2506 Protein transduction domain 1819 Paracrine 1494 Polar protein targeting 2738 Protein vaccination 627 PARP 3061 Polyamines 2095, 2871 Proteinase inhibitors 709 Parvin 25 Polyarginine 1819 Proteinases 709 Pasteur 2237 Polyglutamine expansion 1677 Protein-protein interaction 505 Patched 1249 Polyglutamine 2642 Proteolysis 2405 Pattern formation 1249 Polymers 709 Proteolytic shedding 2669 Patterning 2738 Polyomavirus 865 Protonation and deprotonation 285 Paxillin 25 Polyomavirus-induced nephropathy Pseudogenes 1485 PC12 cells 6 (PVN) 865 Pseudomonas 2804 Peptide processing 2477 Polyphenols 1538, 2847 Psoriasin 1091 Peptide-loading complex 653 Polyploidy 112 Psoriasis 469, 1091 Peptidoglycan 2555 Polyposis 2135 P-type ATPase 2908 Perlecan 2435 Potassium channel 301 Public health 2223 Permeability transition 1440 PPlase 2889 Pufferfish 1564 Permeation 301 PPR protein 698 Pulvinar 1867 Peroxins 1686 Presenilins 1226 Purification 1149, 2597 Peroxisome biogenesis Primary follicle 579 Pyrophosphomonoester 2089 disorder 1752 Primary glial culture 2057 Pyruvate carboxylase 843 Peroxisomes 1553, 1686, 1752 Primordial follicle 579 Pyruvate/citrate shuttle 843 Peutz-Jeghers 2135 Prion 207, 2342 Pyruvate/malate shuttle 843 Pexl9p 1686 Procollagen 1193 PfATP6 1586 Programmed cell death 1937 QL mutants 82 pfert 1586 Progressive multifocal Quality control 1813 pfmdrl 1586 leukoencephalopathy (PML) 865 Quercetin 2847 P-glycoprotein 1038 Prohormone convertase 2477 Phage infection 1899 Proinflammatory response 2352 Rac 2446 Pharmacology 12 Proinsulin C-peptide 1805, 3055 Racl 82,2859 Pheromones 1476, 1658 Prokaryotes 820, 2260 Raf B 637 PhiKMV 1899 Proline concept 3042 RAF 1314 Phosphatase 2A 2979 Proline oxidase 1425 Raf-1 637 Phosphatidylinositol 3-kinase 220 Proprotein convertase 1193 RANK ligand (RANKL) 391 Phosphodiesterase inhibitor 4 Prostaglandin E, 2546 Rapid-reaction technique 2571 (PDE4) 1725 Prostate cancer 435 Rat liver 1790 Phosphoenolpyruvate 890 Protease 2968 Raw starch degradation 2710 Phospholipid 1889 Protease inhibitor 1706 Rb 767 Phosphopeptide 2682 Proteasome 2095 Reactive nitrogen species 1236 Phosphoprotein 378 Protein aggregation 1677 Reactive oxygen species 1236, Phosphoproteome 378 Protein crystallization 285 1440, 2057 Phosphorylation 552, 781, 1945 Protein crystallography 2608 Real-time PCR 2175 Phosphotransferase 890 Protein dynamics 2571 RecA-like motor 1095 Photodynamic therapy 3083 Protein engineering 2992 Receptor binding affinity 2039 Photosynthesis 698 Protein folding 1179, 1923, 2804, Receptors 36, 1410, 1465, 3030 Phylogeny 1125 2889 Recombinant 540, 1149 Phytanic acid 1553, 1752 Protein folding and stability 855 Recombinant expression 3072 Phytic acid 552 Protein function 517 Recombinant protein Phytol 1752 Protein import 1686 expression 2597 PI 3-kinase isoforms 1085 Protein interaction 2792 Reconsolidation 999 Picornavirus 1449 Protein kinase A 1236 Refsum disease 1752 PINCH 25 Protein kinase C 1236 Regenerative medicine 760, 2764 PKA 92, 637 Protein kinase CK2 2183 Reggie 343 Regulation 1736, 2792 Self-replication 1278 Sterne 2237 Regulation of signalling 1632 Semenogelin 2886 Steryl ester 1355 Regulatory domain 2608 Seminal vesicle 2886 Streptavidin 2992 Regulatory network 2260 Sensory 2329 Stress granules 735 Regulon 2260 Sensory afferent fibers 1494 Structural biology 2608 Relational database 36 Sensory physiology 1501 Structural genomics 2597 Relcovaptan 1766 SEPNI1 52 Structural transition 1736 Renal epithelial cell 367 Septal organ 1465 Structure and function 2954 Reproduction 2886 Sequestering 2119 Structure determination 2597 Resistance 163, 1586 Sequestosome (p62) 391 Structure 1149, 1370 Respiratory chain 2415 Serotonin 963, 1494 Structure/function relationship 2792 Reticulon 877, 2027 Serpin 709 Structure-activity 235 Retina 1614 Serpinopathies 709 Structure-function 2755 Retinal 2291 SET domain 2755 Structure-function relationship 100, Retinoblastoma protein 2397 Severing 2119 1294 Retrotransposon 1449 SH2 domain 2682 Subsarcolemmal mitochondria 358 Reverse transcriptase inhibitor Short-chain dehydrogenase Substantia nigra 187 Reverse transcriptase 163 reductase 1205 Substrate reduction therapy 1179 RGS proteins 1510 Sialic acid 1331 Substrates 1912 RGS 1969 Sialic acid-specific lectin 133 Sulprostone 2546 Rhabdomyolysis 2415 Sialoglycoconjugate 1331 Suppression 820 RHD 877 Signal transduction 1085, 1165, Suppressor 1193 Rhizomelic chondrodysplasia 1236, 1579, 1632, 2000, 2067, Surface plasmon resonance 1805, punctata 1752 2446, 2642, 2939 3055 RhoA 82, 112, 2859 Signaling 552, 601, 1314, 1523, Survival 25, 1523 Ribosome-inactivating protein 1850 2682 SV40 small t 2979 Ribozymes 1278 Signaling cascades 961, 989 Sweet proteins 1876 RKIP 637 Signaling pathways 2584 Sweeteners 1876 NA editing 698 Single nucleotide polymorphisms Synapse formation 1833 RNA interference 2102 (SNPs) 6, 1501 Synapses 1494 RNA world 1278 Site-directed mutagenesis 100 Synaptogenesis 399 RNAi 901 Skeletal muscle 2405 Syncytin 1906 RNA-RNA base pairing Skin 1091, 1386 Synteny 1125 ROP 2446 Skin cancer 1266 Synthetic life 1278 ROS production 414 Skin infection 469 rPA 2237 Small G protein 2446 T cell development 60 RPE65 (retinal pigment epithelium Small interfering RNA 2397 T cells 92,2249 65 kDa protein) 2291 Smallpox 2196 TAP 653 rRNA 246 Smeil 1510 Tapasin 653 Rubinstein-Taybi Syndrome Smoothened 1249 Targeted gene deletion 1614 (RTS) 1725 Snake 3030 TASK-3 channel 2364 SNPs 1485 Taste 1510, 2000, 2329 $100 proteins 2387 Social behavior 1476 Taste coding 2000 Sarcomere 723 Solubilization 1149 Taste receptor 1876 SBP2 73 Somatic stem cell 760 Tau 1226 Scaffolding protein 1833 sONE 144 TCP-1 939 Scaffolds 1632 Specific anosmia 1485 Temporin 1060 Schistosoma japonicum 919 SPFH 343 TGF-B 2527 Schistosomula 919 Sphingolipids 1017, 1038 Therapeutic options 2584 Schizophrenia 1597, 2626 Sphingosine |-phosphate 2695 Therapeutic strategy 2079 Schwann cell 2764 Spider silk 1986 Therapeutics 1017 Scramblase 2908 Splicing 2067 Therapy 2642 SDS-gel electrophoresis 1790 SR121463 1766 Thermoresistance 1899 Secondary structure 3042 Sre 2818 Thiamine-responsive megaloblastic Secretase 1538 SSR149415 1766 anemia 1553 Secretion signal 2804 Staging 663 Thionins 1370 Selectivity 301 Starch-binding domain 2710 Threshold sensitivity 1485 Selenium 52 Statins 255, 1165, 2415 Thrombocytopenia 2460 Selenocysteine 73 Staurosporine 378 Thromboembolic disease 2773 Selenoprotein 52 Stem cells 663 Thrombopoiesis 2460 Self-cleaving 2A sequence 1449 Stem-loop 901 Thymosin B-4 663 Self-renewal 760 Stereocilia 2329 Thyroid hormones 414 Tight junction 505 Tribbles 1632 Vaccinia virus 2249 TIRFM 1823 Trigger factor 2889 Vaptans 1766 Tissue repair 2901 Trk 1523 Vascular contractility 565 Tissue-type plasminogen activator Trk inhibitors 755 Vascular endothelial growth (tPA) 709 I'rkB 755 factor 601, 930 TNF-a 2669 tRNA 246, 1813 Vasopressin antagonists 1766 Toll-like receptor 2901 tRNA binding sites 2725 VEGF 601, 2067, 2435 Tolvaptan 1766 tRNA splicing 1813 Venom 3030 Tongue 1501 Tropism 2738 Ventral tegmental area 187, Tonsil 498 TRPC2 channel 1476 1597 Toxin 1850 TRPC6 2506 Vertebrate 672 TPR domain 2889 Trypanosoma brucei 1937 Vesicle budding 2908 Transcription 1009, 2460, 2642 Trypanosoma cruzi 1449 Vesicle sorting 2477 Transcription factors 1393, 2260, Tryptophan hydroxylase-2 Viable but non-culturable 2317 (TPH2) 6 state 2555 lranscriptional activity 487 Tuberculosis 2555 Viral dynamics 832 Transcriptional regulation 268 Tubuliform 1986 Viral lifecycle 865 Transdifferentiation 2764 Tularaemia 2196 Virus assembly 1095 Transduction signal 2016 Tumor 2669 Visual spatial 1867 Transfection 2364 Tumor immunity 627 Visuospatial 1867 Transformation 1314, 2979 Tumor stroma 449 Vitamin B 1553 Transforming growth factor- Tumorigenesis 449, 663 Volume regulation 12 B 2387, 2584 Tweety 12 Vomeronasal organ 1465, 1476 Transgenesis 60 Type 2 diabetes 843 Transgenic mouse 1386 Type I secretion system 2804 Wernicke-Korsakoff Transglycosylases 2555 Tyrosine kinase 2067, 2939 syndrome 1553 Translation 820, 901, 1780 lyrosine kinase receptor 601 Western blot 2364 lranslational regulation 1449 Tyrosine phosphorylation 2682, Williams syndrome 1867 Translocation motof ihepaftit is B 2818 Wnt 1249 virus 627 Wnt/B-catenin 2922 Translocation pore 653 Ubiquitin-specific protease 723 Transmembrane signaling 1614 UCP2 1780 X irradiation 2538 Transmissible spongiform Ultraviolet B 2661 Xenograft models 755 encephalopathies 2342 Ultraviolet radiation 1266 Xenopus laevis oocyte 100 Transplantation 2764 uORF 1780 Transport vesicles 249] uPAR 1028 [Transporters 36 Urokinase receptor 1028 Yeast 1969 Transposon silencing 1933 Utrophin 1614 Treatment 663 Zebrafish 1564 Treatment response 832 Vaccination 2249 Zhx2 2922 Triacylglycerol 1355 Vaccines 2237 Zinc 2886