Table Of Content

Birkhauser Verlag Basel - Boston - Berlin ‘ad Wile ViVi Lew Scope The multidisciplinary journal CMLS, Cellular and Molecular Life Sciences publishes research articles, mini-reviews, reviews and multi-author reviews covering the latest aspects of biological and biomedical research. The journal will consider contributions focusing on molecular and cellular aspects of biomedicine, cell biology, immunology, molecular genetics, neuroscience, biochemistry, pharmacology, and physiology related to pharmacology. Editor-in-chief Editorial Board Advisory Board Professor Dr. P. Jollés K.J.A. Davies, Los Angeles, CA C.C.F. Blake, Oxford Muséum National d’Histoire Naturelle G. Dirheimer, Strasbourg E. Carafoli, Padova Laboratoire de Chimie T. Imoto, Fukuoka R.J.-Y. Chang, Houston, TX des Substances Naturelles H. Jornvall, Stockholm J. Engel, Basel ESA 8041 CNRS E. Kubli, Ziirich U. Feige, Thousand Oaks, CA 63, rue Buffon H.-G. Rammensee, Tiibingen J.-M. Frére, Liége F-75005 Paris / France R. Timpl, Martinsried M. Go, Nagoya W. Wahli, Lausanne T. Kirchhausen, Boston, MA K. Kuchler, Wien Editorial Office F. Mayor Jr., Madrid PJ. Neame, Tampa, FL CMLS R.I. Norman, Leicester Birkhauser Verlag M. Parnham, Zagreb P.O. Box 133 P. Potier, Gif-sur-Yvette CH-4010 Basel / Switzerland J. Slaninova, Praha P. Venetianer, Szeged Tel. +41 61 205 07 68 C. Wernette, Auburn, AL Fax +41 61 205 07 95 e-mail: [email protected] Visit our Web site http://www.birkhauser.ch Subject Index AAA protease 825 Azulenes 626 Cytochrome oxidase 549 Acquisition 742 Azuleny] nitrones 626 Cytoplasmic streaming 227 Actin 181, 184 Activity 363 B-galactosidase 894 DCC 62 Adapter protein 1048 Bacteria 378 Deafness 243, 258 Adenine nucleotide translocator 918 Bacteriophage 580 Deamidase 894 Adenomatous polyposis coli (APC) Binding activity 701 Defensin 32, 94 523 Botulinum toxin 47 Dehydroepiandrosterone sulfate 543 Adipocyte 538 Breakdown 330 Desensitization 558 Aging 807 Detergent-insoluble glycolipid- Agonist 558 Ca” 296 enriched rafts 945 Allele 701 Ca’’-dependent chloride efflux 167 Detoxification 330 Alzheimer's disease, 268, 788 Cadherin 523 Development 155, 296 Amidotransferase 507 Calcium channel 660 Dexamethasone 543 Amyloid B protein (AB) 268 Calcium signalling 991 Diabetes 78, 371 Amyotrophic lateral sclerosis 626 cAMP production 709 Dicarboxylate carrier 918 Angiotensin II 1008 Cancer 427 Differentiation 1008 Animal model 977 Candida albicans 729 dilute 233 Antagonist 427, 558 Capsid 580 Dishevelled (dsh) 523 Antibacterial peptide 174 Carbamoyl! phosphate synthetase DNA microarray 779 Antibiotic 280, 779 507 Dorsoventral axis formation 296 Antibiotic resistance 755 Carboxypeptidase 894 Drosophila melanogaster 634 Antibody 47, 567 Carboxypeptidase P 174 Dynamic instability 133 Antiepileptic 660 Carboxypeptidase Y 174 Antifreeze protein (AFP) 398 Caspase 543, 908 Ecology 742 Antigen 69 Catabolic pathway 330 Efflux 771 Antigen-specific T cell 5 Catabolite 330 Electron crystallography 133 Antihypertensive 660 B-Catenin 523 Electron transfer kinetics 1061 Anti-inflammatory 843 Cathepsin A 894 Elicitin 1020 Antimicrobial peptide 32 Caveolin 945 a-Endosulfine 78 Antioxidant 348, 626 CD94/NKG2 356 Enterobacteria 755 Apo2L (TRAIL) 481 CD95 (Fas/Apol) 481 Enzyme activity 384 apoE receptor 268 Cell adhesion 427 Enzyme complex 894 Apolipoprotein E (apoE) 268 Cell death 378, 1020 Enzyme toxicity 384 Apoprotein 857 Cell degeneration 1061 Enzymology 670 Apoptosis 69, 481, 543, 908, 971, Cell invasion 104 Eperezolid 280 1008 Cell migration 62 Epithelia 32 Aqueous/organic solution 398 Cell motility 104 Essential gene 779 Arachidonic acid 167 CFTR 167 Esterase 894 Arginine biosynthesis 507 Channel 817 Evolution 85, 719, 735 Arthritis 427 Chaperone 580 Experimental allergic Aspirin 305 Chemotherapy 481 encephalomyelitis 5 Assay 626 Chimeric vaccine 47 Extracellular matrix 258 Assembly 580 Chlorophyll 330 Astrocyte 991 Cilia 217 FALS 626 AT1 receptor 1008 Clostridium 755 fem 764 AT2 receptor 1008 CO-dehydrogenase 604 FERM domain 243 Atherosclerosis 857, 977 Complex assembly 825 Ferritin 155 ATP-dependent potassium channel Cortical projection 683 Fertilization 296 (Kar channel) 78 Courtship 634 Fibrinolysis 104 ATP-dependent protease 825 COX 305 Flagella 217 ATP-grasp enzyme 507 Cryo-electron microscopy 184 Food consumption 473 Autoantigen 5 Cryo-oscillation 398 Food-borne pathogens 755 Autoimmune desease 5 Cryo-reaction 398 Free radical 378, 626 Axon guidance 62 C-terminal ladder sequence analysis Frozen 398 Axonal transport 200 174 Axotomy 626 Cystic fibrosis 32 GABAergic neuron 683 AZN 626 Cytochrome 1061 Galactosialidosis 894 B-Galactosidase 894 Inflammation 427 Microtubule 133, 181, 184, 217 Gastrointestinal system 47 Inhibition 549 Microtubule-based motor 200 Geminivirus 313 Inhibitor 384 Mitochondria 817, 825, 1061 Gene expression 660 Innate immunity 32, 94 Mitotic regulation 788 Gene regulation 155 Insect immunity 94 Molecular cloning 660 Gene transfer 719 Insertion sequences 719 Molecular epidemiology 729 Genetic code 85 Insulin-like growth factor (IGF) 348 Molecula: evolution 384 Genomics 779 Insulin receptor and signalling 945 Monocarboxylate carrier 918 Glomerulosclerosis 371 Insulin receptor substrate protein Morphogenesis 580 Glutamate 991 945 Motility 217, 233 Glutamate receptor 461, 558 Insulin resistance 945 Motor protein 227, 243 Glycine 843 Insulin secretion 78 Mouse 363 Glycine receptor 843 Integrin-linked kinase (ILK) 523 MPTP 626 Glycogen synthase kinase 3 Integrin 427 mRNA stability 104 (GSK3) 523 Integron 742 Multidrug resistance 280, 771 Glycosyl-phosphatidylinositol 945 Intermediates 549 Multiple sclerosis 5 Glycosyltransferase 670 Intrathalamic projection 683 Muscle development 442 G-protein-coupled receptor 647 Intron splicing 825 Muscular dystrophy 442 Gram-positive bacteria 280 Intron-encoded RNA 22 Mutation 567, 742 Gut 286 IP3 296 Myocyte 1061 IQ motif 233 Myosin 181, 184, 227, 258 Haemophilus influenzae 729 [ron 155 Myosin family 227 Hap! 415 Ischemia 348 Myosin gene 243 Heat shock element 701 Ischemia/reperfusion 626 MyTH4 domain 243 Helicase 807 Helicobacter pylori 729 Kinesin 181, 184, 200, 217 Natural antibody 1001 Heme signaling 415 Kinesin-like proteins 200 ned 184 Hemolymph 286 Necrosis 971 Hemolysin 735 Laminin isoform 442 Neogenin 62 Hemostasis 977 Lateral hypothalamus 473 Nervous system 47 Heparan sulfate 857 Leptin 473 Netrin 62 Hepatocyte growth factor 371 Linezolid 280 Neuraminidase 894 High-density lipoprotein (HDL) Lipase 857 Neurodegeneration 626 268 Lipoprotein 857 Neuron 200 HLA-E 356 Listeria 755 Neuron-glia interaction 991 HLA-G 356 Liver 363 Neuropeptide Y 473 HMG box 883 Locus of enterocyte effacement 735 Neuroprotection 626 Homeostasis 155 LON 825 NF-«B 305 Horizontal gene transfer 742 LTP 1020 Nickel enzyme 604 Host defense 69 Lymphocyte activation 1048 Nickel transport 604 Human ENSA gene 78 Lymphocyte survival 69 Nickel-processing proteins 604 Humoral rejection 1001 Lymphoid enhancer factor / T cell ninaC 243 Hyaluronan 670 factor (Lef/Tcf) 523 Nitrones 626 Hyaluronan synthase 670 Lysosomal protective protein 894 NKIR 356 Hyaluronate 670 NK-lysin 174 Hydrogenase 604 MALDI mass spectrometry 174 NO degradation 549 a/B Hydrolase fold 894 Malignant glioma 481 NOS 305 Hypersensitivity 1020 MAP kinase 538 Nucleic acid replication 85 Hypoxia 348 mecA 764 Nucleolus 807 Mechanism 549 Nucleotide 133 Ice nucleation proteins (INPs) 398 MEL cells 871 IGF-binding protein (IGFBP) 348 Membrane protein 670 Obesity 473 Immunity 5, 47 c-met 371 Odor 647 Immunity to infection 69 Metabolism 807 Olfaction 647 Immunoglobulin-binding protein Metabolite transport 918 Olfactory 647 286 Metal chaperonin protein 604 Oral vaccine 47 Immunolocalisation 567 Metallocluster assembly 604 Organizational component 683 Immunological memory 69 Metastasis 104 2'-O-ribose methylation 22 Immunoregulation 843 Methicillin resistance 764 Oxazolidinone 280 Immunotherapy 5, 481 Microbial evolution 729 Oxidative stress 626 Induction of erythropoiesis 871 Microorganism 771 Oxygen sensing 415 p190 233 REL cell 871 Synaptic transmission 99] Pancreatic B cell 78 Renal cyst 567 Parkinson's disease 626 Renal disease 371 T cell selection 143 Pathogenesis 719 Resistance 1020 T lymphocyte 69, 1048 Pathogenicity island 719 Resistance mechanism 771 TCR gene rearrangement 143 PBN 626 Respiration 549, 825 Therapeutics 427 PBP2' 764 Respiratory chain 825 Thrombosis 977 PBP2a 764 Reticular discontinuity 683 Thymocyte 543 Penicillin-binding protein 764 Reticular sector 683 Tick 286 Peptide antibiotic 32 Retinitis pigmentosa 258 Tick-borne pathogen transmission Peptide hormone 894 Retrograde signaling 807 286 Peptide synthesis 398 RFLP 356 Tobacco 1020 Peptidoglycan 764 Ribosomal RNA precursor cleavage Transcription 313 Peptidyl-prolyl isomerase 788 22 Transcriptional analysis 779 Perifornical area 473 50S ribosomal subunits 280 Transcriptional regulation 104, 415, Permeability transition 971 Rolling circle 313 871 Pharmacological site 384 Transgenic mice 626 Pheromone 634 Salivary gland 286 Translation initiation 280 Phosphate carrier 918 SAR 1020 Translocation 817 Phospholipase A, 167, 384 SBT 356 Transmitter release 991 Phytophthora 1020 Scaffolding protein 461 Tricarboxylate carrier 918 Picroliv 348 SCP 1020 Trophoblast 356 Pigment 330 Self-tolerance 5 Tubulin 133, 184 PIM1I 825 Senescence 330, 807 Pin! 788 Sensory maps 683 Ubiquitin 908 Placenta 356 Sensory processing 683 unc-5 62 Plant 227, 313 Sex determination 883 unc-6 62 Plant mitochondrial transporter 918 Sexual mosaicism 634 unc-40 62 Plasmid 735 Sexual orientation 634 Unconventional myosin 227, 243 Plasminogen activator 104 Sexual receptiveness 634 Uncoupling protein 918 Plasminogen activator inhibitor 104 Shaker 243 Undercooled 398 Point mutation 719 Shiga toxin 735 uPA receptor 104 Polycystic kidney disease 567 Short sequence repeats 729 Urease 604 Polycystin 567 Signal transduction 104, 305, 567, Uridine diphosphate Polysaccharide 670 1048 glucuronosyltransferase 363 Positive selection 94 Signaling 1020 Usher syndrome 243, 258 PR-39 174 Signaling pathways 1008 Programmed cell death 908 Silencing 807 Vaccine 69, 286 Prohormone processing 709 Sliding velocity 227 Vacuole 330 Prolyl isomerization 788 Slipped strand mispairing 729 Variable number of tandem repeat Promoter 701 SLTEC 735 loci 729 Prostaglandin 305, 991 Small nucleolar RNAs 22 Vesicle transport 233 Porteasome 908 Sodium valproate 363 VIP/PHI precursor 709 Protein import 817 Somite 442 Virulence 735 Protein interaction 817 SOX 883 Virus 580 Protein phosphorylation 788 S-PBN 626 von Willebrand disease 977 Protein synthesis 85 Spin traps 626 von Willebrand factor 977 Protein-DNA complex 313 SRY 883 VTEC 735 Protein-protein interaction 1048 SSO 356 Proteoglycan 857 Staphylococcus aureus 764 wnt 523 Proteolysis 825 STAT 538 Proteomics 779 STEC 735 Xenotransplantation 1001 PSD-95/SAP90 461 Stress 155, 378 Pseudouridine formation 22 Stroke 626 Y chromosome 883 Pyrimidine metabolism 507 Structure 133 Yeast 807, 825 Pythium 1020 Sublethal injury 378 Yeast Rox! 415 Substrate channeling 507 YME1 825 Rapid sequence evolution 883 Suicide response 378 YTA10 (AFG3) 825 Rat B-globin gene 871 Sulfonylurea 78 YTA12 (RCA1) 825 Recombination 719 Superoxide dismutase 626 Regeneration 1008 Synaptic plasticity 461 Author Index Abramson, S. B., 305 Enomoto, N., 843 Laloi, M., 918 Alberti, S., 85 Eriste, E., 709 Langer, T., 825 Aldsworth, T. G., 378 Eudy, J. D., 258 Laping, N. J., 371 Amin, A. R., 305 Lazic, D., 871 Amos, L. A., 184 Favatier, F., 701 LeCam, A., 78 Andersson, M., 174 Firestein, S., 647 Lecea, de L., 473 Arnaiz-Villena, A., 356 Foggensteiner, L., 567 Link, H., 5 Ashton-Rickardt, P. G., 69 Frey, J., 717 Livesey, F. J., 62 Attur, M. G., 305 Frick, W., 945 Lobréaux, S., 155 Aubert, J., 538 Lovenberg, T. W., 709 Gaddipati, J. P., 348 Lowy, E., 356 Banaudha, K. K., 348 Gallinat, S., 1008 Lu, K. P., 788 Bataille, D., 78 Genov, N., 384 Lu, P.-J., 788 Becker, D. A., 626 Ghelli, A., 167 Lucius, R., 1008 Belkum, van A., 729 Gilbert, S. P., 181 Ludden, P. W., 604 Belmonte, N., 538 Giuffre, A., 549 Berciano, M., 356 Glisin, V., 871 Maheshwari, R. K., 348 Berg, J. S., 243 Gomez-Casado, E., 356 Maksymowych, A. B., 47 Berger-Bachi, B., 764 Gray, C. P., 779 Mani, H., 348 Bergman, T., 174 Grignon, N., 155 Martin, M. A., 200 Betzel, C., 384 Gros, I.., 78 Martinez-Laso, J., 356 Bezzi, P., 991 Grujicic, N., 871 Mastrocola, T., 167 Blache, P., 78 Gullberg, D., 442 Mazel, D., 742 Blanck, T. J., 1061 Gutierrez, C., 313 Meisinger, C., 817 Bleakman, D., 558 Mercer, J. A., 233 Hach, A., 415 Blein, J.-P., 1020 Metzner, W., | Hacker, J., 719 Blum, H., 427 Mikes, V., 1020 Hamada, S., 227 Boerlin, P., 735 Milat, M. L., 1020 Hata, Y., 461 Boerth, N. J., 1048 Mitrovic, T., 871 Héron, L., 78 Bonetto, V., 174, 709 Model, K., 817 Hiraiwa, M., 894 Bracy, J. L., 1001 Montero, L., 104 Hirose, K., 184 Bradford, B., 843 Montillet, J.-L., 1020 Holden, H. M., 507 Briat, J.-F., 155 Morales, P., 356 HO6rtensteiner, S., 330 Brix, J., 817 Mori, H., 268 Hughes, A. L., 94 Brunori, M., 549 Miiller, M., 280 Humphries, M. J., 427 Busche, S., 1008 Miiller, G. 945 Hurd, D. D., 200 Mulroy, S., 567 Castro, M. J., 356 Iacomini, J., 1001 Mufioz-Canoves, P., 104 Cheney, R. E., 243 Mutt, V., 174 Ikejema, K., 843 Cole, D. G., 217 Irigoyen, J. P., 104 Constantopoulos, A., 363 Nagamine, Y., 104 Cooper, D. K., 1001 Jacquier-Sarlin, M. R., 701 Nakano, Y., 634 Corder, E. H., 268 Jiang, X.-F., 543 Nepomuceno, D., 709 Crabtree, J. W., 683 Jérnvall, H., 174, 709 Nikéevic, G., 871 Cretin, N., 1001 Nikonoroy, I., 1061 Curley, G. P., 427 Kairis, M., 363 Nogales, E., 133 Karch, H., 719 Norberg, A., 174, 709 Dai, Y.-R., 543 Kashiyama, T., 227 Novak, A., 523 Dani, C., 538 Keck, W., 779 Nuttall, P. A., 286 Davies, J., 742 Kiyatkin, N., 47 DeAngelis, P. L., 670 Kohler, T., 771 Ohlsen, K., 719 Dedhar, S., 523 Kolset, S. O., 857 Oliver, T. N., 243 Denis, C. V., 977 Koretzky, G.A., 1048 O’Neill, M. J., 883 Dodd, C.E., 378 Korhonen, T., 719 O’Neill, R. J., 883 Dokland, T., 580 Koziczak, M., 104 Opferman, J. T., 69 Kroemer, G., 971 Eliceiri, G. L., 22 Kulshreshtha, D. K., 348 Panabiéres, F., 1020 Elliott, J. 1, 143 Kume, S., 296 Pangali, A., 363 Paroli, L., 1061 Schemmer, P., 843 Vajda, T., 398 Pavlovic, S., 871 Schimz, K.-L., 280 Van Dyck, L., 825 Pechére, J.-C., 771 Schroder, J.-M., 32 Vansuyt, G., 155 Pei, X., 543 Seabra, V., 843 Velling, T., 442 Perez-Reyes, E., 660 Sharma, S. K., 348 Vesce, S., 991 Peyrollier, K., 78 Sharman, R. L., 378 Vieira, H. L., 971 Pfanner, N., 817 Sillard, R., 174, 709 Virsolvy, A., 78 Piffaretti, J. C., 717 Silver, R. B., 1061 Volterra, A., 991 Pillinger, M., 305 Simpson, L. L., 47 Plésiat, P., 771 Sinclair, D. A., 807 Wagner, D. D., 977 Polla, B. S., 701 Singh, T. P., 384 Wang, H., 286 Ponchet, M., 1020 Stacklewitz, R. F., 843 Watt, R. K., 604 Popovic, Z., 871 Stubauer, G., 549 Weller, M., 481 Porcelli, A. M., 167 Sumegi, J., 258 Wheeler, M. D., 843 Provance Jr., D. W., 233 Sutcliffe, J. G., 473 Wilson, M. T., 549 Suty, L., 1020 Wojcik, C., 908 Rajashankar, K. R., 384 Swierczewski, E., 701 Wulf, G., 788 Raushel, F. M., 507 Syriopoulou, V., 363 Roma-Giannikou, E., 363 Xiao, B-G., 5 Rose, M. L., 843 Takai, Y., 461 Rosenstiel, P., 1008 Teuber, M., 755 Yamamoto, Roth, W., 481 Thoden, J. B., 507 Yamamoto, Rugolo, M., 167 Thurman, R. G., 843 Yan, C.-H., 5 Rusyn, I., 843 Tiger, C.-F., 442 Yin, M., 843 Ryan, M. T., 817 Tirilly, Y., 1020 Titus, M. A., 181 Zhang, L., 415 Salmivirta, M., 857 Tomiyama, T., 268 Zhao, H., 647 Sandford, R., 567 Trapaga, J., 356 Zhong, Z., 843 Sarafidou, J., 363 Triantaphylides, C., 1020 Zhou, X. Z., 788 Sarti, P., 549, 1061 Ziebuhr, W., 719 Saxton, W. M., 200 Unger, T., 1008