Cell Volume and Signaling PDF
Preview Cell Volume and Signaling
Cell Volume and Signaling ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 551 POST GENOMIC PERSPECTIVES IN MODELING AND CONTROL OF BREATHING Edited by Jean Champagnat, Monique Denavit-Saubie, Gilles Fortin, Arthur S. Foutz, and Muriel Thoby-Brisson Volume 552 TYPE I DIABETES: Biomedical Science and Technology Edited by George Eisenbarth Volume 553 BIOMATERIALS: From Molecules to Engineered Tissues Edited by Nesrin Hasırcı and Vasıf Hasırcı Volume 554 PROTECTING INFANTS THROUGH HUMAN MILK: Advancing the Scientific Evidence Edited by Larry K. Pickering, Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, and Richard J. Schanler Volume 555 BREAST FEEEDING: Early Influences on Later Health Edited by Gail Goldberg, Andrew Prentice, Ann Prentice, Suzanne Filteau, and Elsie Widdowson Volume 556 IMMUNOINFORMATICS: Opportunities and Challenges of Bridging Immunology with Computer and Information Sciences Edited by Christian Schoenbach, V. Brusic, and Akihiko Konagaya Volume 557 BRAIN REPAIR Edited by M. Ba¨hr Volume 558 DEFECTS OF SECRETION IN CYSTIC FIBROSIS Edited by Carsten Schultz Volume 559 CELL VOLUME AND SIGNALING Edited by Peter K. Lauf and Norma C. Adragna A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. Cell Volume and Signaling Edited by Peter K. Lauf Wright State University Dayton, Ohio and Norma C. Adragna Wright State University Dayton, Ohio A C.I.P. Catalogue record for this book is available from the Library of Congress. ISSN: 0065 2598 ISBN: 0-387-23299-0 Proceedings of the 2003 Dayton International Symposium on Cell Volume Regulation and Signaling (cid:1)2004 Springer Science(cid:1)Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science(cid:1)Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America. 9 8 7 6 5 4 3 2 springeronline.com FOREWORD In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments). The special touch of our Symposium Coordinator / Editorial Assistant Donna Maas was reflected in the management and organization of the symposium details, generation of program highlights, and finally, as you all know from the many e-mails, in the hard work thereafter to edit all our chapters readying them for final publication. We all owe her a big thanks and round of applause. In the final layout of this volume and the listing of its chapters, we adhered to the original program which divided the symposium into four major topics at the cutting edge of research in cell volume and signal transduction. There is an Abstract appendix containing those abstracts that were expanded by some of the poster presenters. At the concluding dinner of the Dayton International Symposium at the Dayton Art Institute, our dear colleague and friend Hector Rasgados-Flores, physiologist and composer, dedicated a Sarabanda for Cello and Piano which he together with our cellist son Adrian Lauf performed. This fine piece of music is published herein for the first time and interwoven between the chapters and abstracts. Our special thanks to every member on the Editorial/Advisory Committee for reviewing and editing each page of this book. On behalf of the members of this committee and Wright State University, we would like to thank all who helped and our colleagues and friends who came from near and far to make the 2003 Dayton International Symposium on Cell Volume and Signal Transduction such a resounding success. For the Editorial/Advisory Committee, Peter K. Lauf, Norma C. Adragna University Professor Professor of Pharmacology & Toxicology v DEDICATION Monte Arnold Greer (1922-2002) This Symposium is dedicated to the memory of Monte Arnold Greer, pioneer in the field of cell swelling-induced secretion, exceptional scientist and rare friend, who died on March 24, 2002 in an auto accident in Oregon. It was in the early eighties when Monte noticed that an improperly prepared perfusion solution was surprisingly effective in the stimulation of pituitary hormone secretion. Interestingly enough, secretion returned to basal values and responded again to different stimuli. It looked like a joke and that was enough to attract Monte’s attention. He was unaware of any similar observations. Now, we know that some other people noticed a similar behavior for one particular hormone, but it was Monte who was thunderstruck by finding that it was a broad, universal phenomenon. And so this highly reputed neuroendocrinologist spent the rest of his carrier studying and admiring cell swelling-induced hormone secretion. Illustrative is the title of his paper: Greer MA, Greer SE, Opsahl Z, McCafferty L, Maruta S: Hyposmolar stimulation of in vitro pituitary secretion of luteinizing hormone: a potent clue to the secretory process, Endocrinology 113: 1531-1533,1983. Over the following years, Monte published many elegant papers in prestigious scientific journals; however, he did not evoke an expected interest among orthodox endocrinologists. In the years 1994-1998, we worked on a joint project Isosmotic Ethanol-induced Neural Cell Swelling and Thyroliberin Release supported by the US-Slovak Science and Technology Cooperation Program. During one of my visits in Portland, Monte suggested contacting relevant people in various fields to organize a symposium on cell swelling. We were impressed by the number of top scientists who worked on cell volume regulation and were pleased that many of them attended our first International Symposium on Primary Role of Cell Volume Changes in Controlling Cell Function, in Smolenice Castle in Slovakia, June 23-27, 1997. As the main organizers, Monte, Florian Lang and I served as chairpersons of the meeting. That was the beginning of this series. It was followed by the International Conference on Cell Volume: Signalling and Regulation, Max Plank Institute, Berlin, October 25-28, 2000, and now, by the present International Symposium on Cell Volume & Signaling, September 20-24, 2003, at Wright State University in Dayton, Ohio. Monte Arnold Greer was born in Portland, Oregon; he received his A.B. in Biology (1944) and M.D. (1947) at Stanford University. After working in Bethesda, Boston and San Francisco, he accepted an offer as head of the Division of Endocrinology, Department of Medicine, Oregon Health Sciences University, in Portland, Oregon, in vii viii DEDICATION 1956. Under his leadership (1956-1990), first as Associate Professor of Medicine (1956) and then Professor of Medicine and Physiology (1962), the Endocrinology Division in Portland developed into an eminent clinical and research institution. Monte Greer was an excellent clinician and gifted researcher who pioneered work in several fields. Most acknowledged has been the field of hypothalamic regulation of pituitary hormone secretion. He was the first to publish proof of the role of the hypothalamus in thyroid regulation – a lesion of the hypothalamus prevented goiter development in experimental rats. Twenty-five years later, A. Shally and R. Guilemin shared the Nobel Prize for the isolation of the thyrotropin-releasing hormone from the hypothalamus. Naturally, Monte was included in the prestigious publication: Pioneers in Neuroendocrinology (M. A. Greer: Why I am still waiting for the free trip to Stockholm, chapter 13, Plenum Publishing Corporation, 1978). Among the awards Monte Greer received were the Oppenheimer Award of the Endo- crine Society and Honorary memberships in the Japanese and Czechoslovak Endocrine Societies. Monte’s achievements were also recognized by his appropriate roles in professional societies: American Thyroid Association President Endocrine Society Vice President Western Society for Clinical Research President American Society for Clinical research Chair, Subsection on Endocrinology In addition, he served as a member of the editorial boards of Endocrinology, Neuroendo- crinologyandEndocrinologia Experimentalis. Monte’s charming personality, esprit, rare sense of humor and friendliness made him popular with friends all over the world. His personality is best reflected in his statement: “Nobody is as bad as his publications!” The sad message of his death deeply touched his former research fellows and coworkers and their families in USA, Japan, Switzerland, France, Germany, Slovakia, China and possibly other countries. We are all very pleased to devote this exciting meeting to the memory of our friend Monte Arnold Greer. Vladimir Strbak ACKNOWLEDGMENTS We want to express our gratitude for the unflagging support—moral and financial— we received from Wright State University, in particular: Dr. Perry Moore, Executive Vice President Dr. David Hopkins, Provost Dr. Joseph Thomas, Associate Provost Dr. Howard Part, Dean, School of Medicine Mr. John Bale, Associate Dean, School of Medicine Dr. Robert Fyffe, Associate Dean for Research Affairs, School of Medicine Dr. Michele Wheatly, Dean, College of Science and Mathematics Dr. Gerald Alter, Biomedical Sciences Ph.D. Program Dr. Arthur Pickoff, Department of Pediatrics, Children’s Medical Center This symposium was supported by a grant from the National Institute of Diabetes, Digestive and Kidney Diseases of the National Institutes of Health (1R13DK064886- 01).We would like to thank Program Director Dr. David Badman,for helping us achieve the goals of this meeting. In addition, our thanks go to Mr. Bob Coyne of Fuji Medical Systems for his generous support of the 2003 Dayton International Symposium on Cell Volume Regulation and Signaling. ix CONTENTS FOREWORD.............................................................................................................. v DEDICATION ............................................................................................................ vii ACKNOWLEDGMENTS ......................................................................................... ix 1. THE BALANCING ACT OF THE NAKED CELL: A BRIEF HISTORY OF MEMBRANE REGULATION OF ANIMAL CELL VOLUME BEFORE 1978 ...................................... 1 John S. Willis (Pre-Symposium Lecturer) ELECTRONEUTRAL COTRANSPORTERS 2. TWENTY-FIVE YEARS OF K-Cl COTRANSPORT: FROM STIMULATION BY A THIOL REACTION TO CLONING OF THE FULL-LENGTH KCCs .......................................... 11 Peter K. Lauf and Norma C. Adragna 3. MOLECULAR PHYSIOLOGY OF MAMMALIAN K+-CL- COTRANSPORTERS ................................................................................. 29 Adriana Mercado, Gerardo Gamba, and David B. Mount 4. STE20 KINASES AND CATION-CHLORIDE COTRANSPORTERS:AMINIREVIEW ............................................... 43 Eric Delpire 5. MOLECULAR PHYSIOLOGY OF THE RENAL Na+:Cl- AND Na+:K+:2Cl- COTRANSPORTERS .................................... 55 Gerardo Gamba and Norma A. Bobadilla xi xii CONTENTS 6. THE ROLE OF THE BLOOD-BRAIN BARRIER Na-K-Cl COTRANSPORTER IN STROKE: A Minireview .................................. 67 Martha E. O’Donnell, Tina I. Lam, Lien Tran and Steven E. Anderson 7. REGULATION OF Na-K-2Cl COTRANSPORT IN RED CELLS ........................................................................................... 77 Peter Flatman 8. A NOVEL NHE1 FROM RED BLOOD CELLS OF THE WINTER FLOUNDER: REGULATION BY MULTIPLE SIGNALING PATHWAYS ........................................................................ 89 Stine F. Pedersen ION CHANNELS AND EXCHANGERS 9. PROBING OF THE ICln CHANNEL PORE BY CYSTEINE MUTAGENESIS AND CADMIUM-BLOCK .......................................... 99 M. Jakab, M. L. Garavaglia, J. Fürst, S. Rodighiero, F. Guizzardi, G. Meyer, M. Ritter, and M. Paulmichl 10. VOLUME–DEPENDENT AND -INDEPENDENT ACTIVATED ANION CONDUCTANCES AND THEIR INTERACTION IN THE RENAL INNER MEDULLARY COLLECTING DUCT (IMCD) ............................................................................................. 109 Stefan H. Boese, Mike A. Gray, and Nick L. Simmons 11. SECRETORY CONTROL OF BASOLATERAL MEMBRANE POTASSIUM AND CHLORIDE CHANNELS IN COLONIC CRYPT CELLS ........................................................................................... 119 Dan R. Halm 12. EFFECTS OF AMMONIUM ON ION CHANNELS AND TRANSPORTERS IN COLONIC SECRETORY CELLS ..................... 131 Roger T. Worrell and Jeffrey B. Matthews 13. THE VOLUME-ACTIVATED CHLORIDE CURRENT DEPENDS ON PHOSPHOLIPASE C ACTIVATION AND INTRACELLULAR CALCIUM MOBILIZATION ............................... 141 D. Varela, F. Simon, A. Riveros, F. Jørgensen and A. Stutzin 14. NITRIC OXIDE (NO) MODULATION OF CL-DEPENDENT TRANSPORTERS IN THE KIDNEY ....................................................... 147 Pablo A. Ortiz and Jeffrey L. Garvin
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