Cell of Immunoglobulin Synthesis

416 Pages·1979·9.89 MB·English

by  Benvenuto Pernis (Eds.)

P & S BIOMEDICAL SCIENCES SYMPOSIA Series
HENRY J. VOGEL, Editor
College of Physicians and Surgeons
Columhia University
New York, New York
Henry J. Vogel (Editor). Nucleic Acid-Protein Recognition, 1977
Arthur Karlin, Virginia M. Tennyson, and Henry J. Vogel (Editors).
Neuronal Information Transfer, 1978
Benvenuto Pernis and Henry J. Vogel (Editors). Cells of Immuno-
globulin Synthesis, 1979
CELLS OF
IMMUNOGLOBULIN
SYNTHESIS
Edited by
BENVENUTO PERNIS
HENRY J. VOGEL
College of Physicians and Surgeons
Columbia University
New York, New York
ACADEMIC PRESS
New York San Francisco . London 1979
A Subsidiary of Harcourt Brace Jovanovich, Publishers
COPYRIGHT © 1979, BY ACADEMIC PRESS, INC.
ALL RIGHTS RESERVED.
NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR
TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC
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ACADEMIC PRESS, INC.
Ill Fifth Avenue, New York, New York 10003
United Kingdom Edition published by
ACADEMIC PRESS, INC. (LONDON) LTD.
24/28 Oval Road, London NW1 7DX
Library of Congress Cataloging in Publication Data
Main entry under title:
Cells of immunoglobulin synthesis.
(P & S biomedical sciences symposia series)
Proceedings of a symposium held at Arden House,
June 9-11, 1978.
Includes bibliographical references.
1. Immunoglobulins—Congresses. 2. B cells—
Congresses. 3. Immunogenetics—Congresses. 4. Pro-
tein biosynthesis—Congresses. I. Pernis, Benvenuto.
II. Vogel, Henry James, Date III. Series.
[DNLM: 1. Immunoglobulins—Biosynthesis—Congresses.
2. Cytology—Congresses. QW601 C393 1978]
QR186.7.C44 599\02,93 78-20000
ISBN 0-12-551850-1
PRINTED IN THE UNITED STATES OF AMERICA
79 80 81 82 9 8 7 6 5 4 3 2 1
List of Participants
AHMED, AFTAB, Department of Immunology, Naval Medical Research Insti-
tute, Bethesda, Maryland 20014
ANDERSSON, J., Department of Immunology, Biomedical Center, Uppsala
University, S-75123 Uppsala, Sweden
ANDREWS, P. W., Memorial Sloan-Kettering Cancer Center, New York, New
York 10021
BERGER, CAROLE L., Department of Dermatology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
BERMAN, MONIQUE A., Department of Immunopathology, Scripps Clinic and
Research Foundation, La Jolla, California 92037
BEYCHOK, SHERMAN, Department of Biological Sciences, Columbia Univer-
sity, New York, New York 10032
BLANC, WILLIAM E., Department of Pathology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
BONAGURA, VINCENT R., Department of Microbiology, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
BRACK, CHRISTINE, Basel Institute for Immunology, Postfach, 4005 Basel 5,
Switzerland
BRANWOOD, A. MARY, Department of Pathology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
BRILES, DAVID E., Department of Neurobiology, Cellular Immunology Unit,
The University of Alabama in Birmingham, Birmingham, Alabama 35294
BUTLER, VINCENT P., JR., Department of Medicine, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
BUXBAUM, JOEL, Research Service, Veterans Administration Hospital, New
York, New York 10010
CATHOU, RENATA E., Department of Biochemistry, Tufts University School of
Medicine, Boston, Massachusetts 02111
CAZENAVE, PIERRE-ANDRE, Service d'Immunochimie Analytique, Institut
Pasteur, 75724 Paris, Cedex 15, France
CHASE, MERRILL W., The Rockefeller University, New York, New York 10021
CHESKIN, HOWARD S., Department of Pathology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
CHIORAZZI, N., The Rockefeller University, New York, New York 10021
xiii
XIV LIST OF PARTICIPANTS
CHOI, EDMUND, Department of Microbiology and Immunology, UCLA School
of Medicine, University of California, Los Angeles, California 90024
CLEVELAND, W. L., Department of Microbiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
CLEVINGER, BRIAN, Department of Microbiology and Immunology, Washing-
ton University School of Medicine, St. Louis, Missouri 63110
CONE, ROBERT, Department of Pathology, Yale University School of Medi-
cine, New Haven, Connecticut 06510
COOK, WENDY D., Department of Cell Biology, Albert Einstein College of
Medicine, New York, New York 10461
COOPER, MAX D., The Cellular Immunobiology Unit of the Tumor Institute,
University of Alabama, Birmingham, Alabama 35294
COSENZA, HUMBERTO, Department of Microbiology, University of Honduras,
Tegucigalpa, Honduras
COUTINHO, A., Basel Institute for Immunology, Postfach, 4005 Basel 5, Swit-
zerland
CRABEEL, MARJOLAINE, Laboratory of Microbiology, Free University of Brus-
sels, Research Institute, C.E.R.I.A., B1070 Brussels, Belgium
CUNIN, RAYMOND, Laboratory of Microbiology, Free University of Brussels,
Research Institute, C.E.R.I.A., B1070 Brussels, Belgium
DA VIE, JOSEPH M., Department of Microbiology and Immunology, Washing-
ton University School of Medicine, St. Louis, Missouri 63110
DHARMGRONGARTAMA, BEN, Department of Cell Biology, Albert Einstein
College of Medicine, New York, New York 10461
DICKLER, HOWARD B., Immunology Branch, National Cancer Institute, Na-
tional Institutes of Health, Bethesda, Maryland 20014
DURKIN, HELEN C, Department of Pathology, Downstate Medical College,
Brooklyn, New York 11203
ECKHARDT, THOMAS, Department of Microbiology, New York University,
New York, New York 10016
EDELIST, TRUDY, Department of Pathology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
EISENBERG, MAX A., Department of Biochemistry, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
FEINSTEIN, A., A.R.C. Institute of Animal Physiology, Babraham, Cambridge,
Cambridgeshire, England
FENOGLIO, CECILIA M., Department of Pathology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
FINGER, IRVING, Department of Biology, Haverford College, Haverford,
Pennsylvania 19041
FORNI, LUCIANA. Basel Institute for Immunology, Postfach, 4005 Basel 5 ,
Switzerland
FRANGIONE, BLAS, Department of Pathology, New York University Medical
Center, New York, New York 10016
FRANKLIN, EDWARD C, Department of Medicine, New York University Col-
lege of Medicine, New York, New York 10016
LIST OF PARTICIPANTS XV
Fu, S. M., The Rockefeller University, New York, New York 10021
FUNG, JOHN, Department of Pathology, La Rabida-University of Chicago
Institute, Chicago, Illinois 60649
GATES, FREDERICK T., Ill, National Institute of Allergy and Infectious Dis-
eases, National Institutes of Health, Bethesda, Maryland 20014
GILMORE-HEBERT, MAUREEN, Department of Microbiology and Immunol-
ogy, UCLA School of Medicine, University of California, Los Angeles,
California 90024
GlNDES, D., Department of Microbiology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
GODING, JAMES W., Department of Genetics, Stanford University School of
Medicine, Stanford, California 94305
GODMAN, GABRIEL C, Department of Pathology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
GOIDL, EDMOND A., Department of Medicine, Cornell University School of
Medicine, New York, New York 10021
GOLD, LESLIE, Department of Medicine, New York University School of Med-
icine, New York, New York 10016
GOTTLIEB, PAUL D., Center for Cancer Research, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139
GOYERT, SANNA, Department of Pathology, New York University School of
Medicine, New York, New York 10016
GRIFFITH, ROGERS, Department of Microbiology and Immunology, Washing-
ton University School of Medicine, St. Louis, Missouri 63110
HABICHT, GAIL S., Department of Pathology, State University of New York,
Stony Brook, New York 11794
HALPER, JAMES, Department of Microbiology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
HALPER, J. P., The Rockefeller University, New York, New York 10021
HAMLYN, P. H., MRC Laboratory of Molecular Biology, Cambridge, England
HANSBURG, DANIEL, Department of Microbiology and Immunology, Wash-
ington University School of Medicine, St. Louis, Missouri 63110
HARRINGTON, WILLIAM N., Department of Pathology, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
HENDERSON, EDWARD S., Department of Medicine, Roswell Park Memorial
Institute, Buffalo, New York 14263
HERCULES, KATHLEEN, Department of Biological Chemistry, UCLA School of
Medicine, University of California, Los Angeles, California 90024
HERZENBERG, LEONARD A., Department of Genetics, Stanford University
School of Medicine, Stanford, California 94305
HERZENBERG, LEONORE A., Department of Genetics, Stanford University
School of Medicine, Stanford, California 94305
HIRAMA, MINORU, Basel Institute for Immunology, Postfach, 4005 Basel 5,
Switzerland
HODES, RICHARD J., Immunology Branch, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland 20014
XVI LIST OF PARTICIPANTS
HUMPHREY, RICHARD L., The Johns Hopkins Oncology Center, Johns Hop-
kins University School of Medicine, Baltimore, Maryland 21205
HURLEY, J. N., The Rockefeller University, New York, New York 10021
ISHIZAKA, KIMISHIGE, The Johns Hopkins University at the Good Samaritan
Hospital, Baltimore, Maryland 21239
JACOBSON, ETHEL B., Merck Institute for Therapeutic Research, Rahway,
New Jersey 07065
JONES, PATRICIA P., Department of Genetics, Stanford University School of
Medicine, Stanford, California 94305
JOSEPHSON, ALAN G., Department of Medicine, State University of New York,
Brooklyn, New York 11203
KABAT, ELVIN A., Department of Microbiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
KAPLAN, DAVID, Department of Pathology, La Rabida—University of Chicago
Institute, Chicago, Illinois 60649
KAPLAN, RUTH, Department of Pathology, La Rabida-University of Chicago
Institute, Chicago, Illinois 60649
KASICA, DEBORAH, Department of Pathology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
KAZIN, ALICE R., Sloan-Kettering Institute for Cancer Research, Rye, New
York 10580
KELSOE, GARNETT, Department of Microbiology, Harvard University, Boston,
Massachusetts 02115
KlNCADE, PAUL W., Sloan-Kettering Institute for Cancer Research, Rye, New
York 10580
KLINMAN, NORMAN R., Department of Cellular and Developmental Im-
munology, Scripps Clinic and Research Foundation, La Jolla, California
92037
KNOPF, PAUL M., Division of Biology and Medicine, Brown University, Pro-
vidence, Rhode Island 02912
KÖHLER, GEORGES, Basel Institute for Immunology, Postfach, 4005 Basel 5,
Switzerland
KÖHLER, HEINZ, Department of Pathology, La Rabida-University of Chicago
Institute, Chicago, Illinois 60649
KOMAROMY, MICHAEL, Department of Microbiology and Immunology, UCLA
School of Medicine, University of California, Los Angeles, California
90024
KOSHLAND, MARIAN ELLIOTT., Department of Bacteriology and Immunology,
University of California, Berkeley, California 94720
KOWALIK, SHARON, Department of Pathology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
KUNKEL, H. G., The Rockefeller University, New York, New York 10021
LATOVITZKI, NORMAN, Department of Neurology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
LAWTON, ALEXANDER R., The Cellular Immunobiology Unit of the Tumor
Institute, University of Alabama, Birmingham, Alabama 35294
LIST OF PARTICIPANTS XV11
LE GUERN, CHRISTIAN, Service d'Immunochimie Analytique, Institut Pas-
teur, 75724 Paris, Cedex 15, France
LEISINGER, THOMAS, Mikrobiologisches Institut, Eidgenössische Technische
Hochschule, Zurich, Switzerland
LENHARD-SCHULLER, RITA, Basel Institute for Immunology, Postfach, 4005
Basel 5, Switzerland
LEVINTHAL, CYRUS, Department of Biological Sciences, Columbia Univer-
sity, New York, New York 10027
LlTWlN, STEPHEN D., Department of Medicine, Cornell University Medical
College, New York, New York 10021
LOVE, PATRICIA Y., Department of Microbiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
MANGOLD, BEVERLY, Division of Biology and Medicine, Brown University,
Providence, Rhode Island 02912
MARKS, PAUL A., Office of the Vice President for Health Sciences, Columbia
University, New York, New York 10032
MARTINIS, JOANNE, Wistar Institute, Philadelphia, Pennsylvania 19104
MATHER, ELIZABETH L., Department of Bacteriology and Immunology, Uni-
versity of California, Berkeley, California 94720
MATSUUCHI, LINDA, Department of Microbiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
MCCLELLAND, KATHARINE, Department of Pathology, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
MclLHlNNEY, R. A. J., A.R.C. Institute of Animal Physiology, Babraham,
Cambridge, Cambridgeshire, England
MELCHERS, F., Basel Institute for Immunology, Postfach, 4005 Basel 5, Swit-
zerland
MESA-TEJADA, RICARDO, Department of Pathology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
METCALF, ELEANOR S., Department of Microbiology, Uniformed Services
University of the Health Sciences, Bethesda, Maryland 20014
MILSTEIN, C, MRC Laboratory of Molecular Biology, Cambridge, En-
gland
MITSIALIS, S. ALEXANDER, Department of Microbiology, College of Physi-
cians and Surgeons, Columbia University, New York, New York 10032
MOND, JAMES J., Laboratory of Immunology, National Institute of Allergy and
Infectious Diseases, National Institutes of Health, Bethesda, Maryland
20014
MORAN, MARY C, Department of Pathology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
MORRISON, SHERIE L., Department of Microbiology, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
MOSIER, DONALD E., Laboratory of Immunology, National Institute of Allergy
and Infectious Diseases, National Institutes of Health, Bethesda, Mary-
land 20014
NEILSON, ERIC G., Department of Medicine, Allergy, and Immunology, Uni-
XV111 LIST OF PARTICIPANTS
versity of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
19104
NISONOFF, ALFRED, Rosenstiel Basic Sciences Research Center, Brandeis Uni-
versity, Waltham, Massachusetts 02154
NOSSAL, SIR GUSTAV, The Walter and Eliza Hall Institute of Medical Re-
search, Melbourne, Victoria 3050, Australia
O'DONOVAN, GERARD A., Department of Biochemistry and Biophysics, Texas
A & M University, College Station, Texas 77843
Oi, VERNON T., Department of Genetics, Stanford University School of Medi-
cine, Stanford, California 94305
OSSERMAN, ELLIOTT F., Department of Medicine, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
PALUCH, EDWARD, Department of Pathology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
PARONETTO, FIORENZO, Department of Pathology, Mt. Sinai School of Medi-
cine, New York, New York 10029
PAUL, WILLIAM E., Laboratory of Immunology, National Institute of Allergy
and Infectious Diseases, National Institutes of Health, Bethesda, Mary-
land 20014
PEREIRA, MIERCIO E. A., Department of Microbiology, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
PERLMUTTER, ROGER M., Department of Microbiology and Immunol-
ogy, Washington University School of Medicine, St. Louis, Missouri
63110
PERNIS, BENVENUTO, Departments of Microbiology and Medicine, College of
Physicians and Surgeons, Columbia University, New York, New York
10032
PESTKA, SIDNEY, Roche Institute of Molecular Biology, Nutley, New Jersey
07110
PHILLIPS, S. MICHAEL, Department of Medicine, Allergy and Immunology,
University of Pennsylvania School of Medicine, Philadelphia, Pennsyl-
vania 19104
PHILLIPS, STEPHANIE, Department of Human Genetics, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
PIERCE, SUSAN K., Department of Biochemistry and Molecular Biology,
Northwestern University, Evanston, Illinois 60201
PINCUS, SETH H., Immunology Branch, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland 20014
PITT, JANE, Department of Pediatrics, College of Physicians and Surgeons,
Columbia University, New York, New York 10032
POLLACK, MARILYN S., Memorial Sloan-Kettering Cancer Center, New York,
New York 10021
POTASH, MARY J., Division of Biology and Medicine, Brown University, Pro-
vidence, Rhode Island 02912
PRAKASH, OM, Department of Biochemistry, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
LIST OF PARTICIPANTS xix
QUINTANS, JOSE, Department of Pathology, La Rabida-University of Chicago
Institute, Chicago, Illinois 60649
READ, STANLEY E., The Rockefeller University, New York, New York
10021
RICHARDSON, N. E., A.R.C. Institute of Animal Physiology, Babraham, Cam-
bridge, Cambridgeshire, England
RIFKIND, RICHARD A., Departments of Medicine and Human Genetics and
Development, College of Physicians and Surgeons, Columbia University,
New York, New York 10032
ROTH, PHILIP, Department of Microbiology, College of Physicians and Sur-
geons, Columbia University, New York, New York 10032
ROTH, RICHARD A., Department of Bacteriology and Immunology, University
of California, Berkeley, California 94720
SABBATH, MARLENE, Department of Pathology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
SCHARFF, MATTHEW D., Department of Cell Biology, Albert Einstein Col-
lege of Medicine, New York, New York 10461
SCHEID, MARGIT, Sloan-Kettering Institute for Cancer Research, New York,
New York 10021
SCHER, IRWIN, Department of Experimental Pathology, Naval Medical Re-
search Institute, Bethesda, Maryland 20014
SEEGAL, BEATRICE C, Department of Microbiology, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
SETCAVAGE, THOMAS M., Sloan-Kettering Institute for Cancer Research, Rye,
New York 10580
SHARON, JAQUELINE, Department of Microbiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032
SHEN, F.-W., Sloan-Kettering Institute for Cancer Research, New York, New
York 10021
SHULMAN, MARC, Basel Institute for Immunology, Postfach, 4005 Basel 5,
Switzerland
SlECKMANN, DONNA C, Laboratory of Immunology, National Institute of Al-
lergy and Infectious Diseases, National Institutes of Health, Bethesda,
Maryland 20014
SlEGAL, FREDERICK P., Sloan-Kettering Institute for Cancer Research, New
York, New York 10021
SINGER, ALFRED, Immunology Branch, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland 20014
SISKIND, GREGORY W., Division of Allergy and Immunology, Department of
Medicine, Cornell University Medical College, New York, New York
10021
SLOVIN, SUSAN F., Department of Clinical Research, Scripps Clinic and Re-
search Foundation, La Jolla, California 92037
SUBBARAO, BONDADA, Laboratory of Immunology, National Institute of Al-
lergy and Infectious Diseases, National Institutes of Health, Bethesda,
Maryland 20014