Cell Death Autophagy, Apoptosisi and Necrosis

437 Pages·2015·12.779 MB·English

by  Tobias M. Ntuli

Cell Death
Autophagy, Apoptosisi and Necrosis
Edited by Tobias M. Ntuli
Cell Death: Autophagy, Apoptosisi and Necrosis
Edited by Tobias M. Ntuli
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Copyright © 2015
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Published December 17, 2015
ISBN-10: 953-51-2236-3
ISBN-13: 978-953-51-2236-4
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C ontents
Preface
Chapter 1 Autophagy in Cell Fate and Diseases
by Daniel Grasso, Alejandro Ropolo and Maria I. Vaccaro
Chapter 2 Interconnected Regulation of Apoptosis and WIPI-Mediated
Autophagy
by Katharina Sporbeck, Fenja Odendall and Tassula Proikas-
Cezanne
Chapter 3 Autophagy Regulation of the Tumor Immunity – An Old
Machinery for a New Function
by Tsolere Arakelian, Takouhie Mgrditchian, Elodie Viry, Kris
Van Moer, Guy Berchem, Salem Chouaib and Bassam Janji
Chapter 4 Targeting the Autophagy Process in Breast Cancer
Development and Treatment
by Joanna Magdalena Zarzynska
Chapter 5 The Role of Autophagy and Apoptosis During Embryo
Development
by M. Agnello, L. Bosco, R. Chiarelli, C. Martino and M. C.
Roccheri
Chapter 6 Mitophagy Regulated by the PINK1-Parkin Pathway
by Taku Arano and Yuzuru Imai
Chapter 7 The Role of Cell Autophagy in Cancer and Its Application in
Drug Discovery
by Ming Hong, Ning Wang and Yibin Feng
Chapter 8 Modulation of Autophagy by Free Fatty Acids
by Jiuhui Wang and Daotai Nie
Chapter 9 Autophagy as a Therapeutic Target in Gastrointestinal
Cancer
by Michiko Shintani
VI Contents
Chapter 10 Apoptotic Molecular Advances in Breast Cancer Management
by Pontsho Moela and Lesetja R. Motadi
Chapter 11 Between Armour and Weapons — Cell Death Mechanisms in
Trypanosomatid Parasites
by Rubem Figueiredo Sadok Menna-Barreto and Solange Lisboa
de Castro
Chapter 12 Apoptosis and Infections
by Yorulmaz Hatice
Chapter 13 Caspases as Putative Biomarkers of Cervical Cancer
Development
by Olga V. Kurmyshkina, Pavel I. Kovchur and Tatyana O. Volkova
Chapter 14 The Apoptotic Microtubule Network During the Execution
Phase of Apoptosis
by Manuel Oropesa Ávila, Alejandro Fernández Vega, Juan
Garrido Maraver, Marina Villanueva Paz, Isabel De Lavera, Mario De La
Mata, Mario D. Cordero, Elizabet Alcocer Gómez, Ana Delgado Pavón,
Mónica Álvarez Córdoba, David Cotán and José Antonio Sánchez-Alcázar
Chapter 15 Steroidal Saponins and Cell Death in Cancer
by María L. Escobar-Sánchez, Luis Sánchez-Sánchez and Jesús
Sandoval-Ramírez
Chapter 16 Cell Death Induction by Targeting Tumor Metabolism
by Karin von Schwarzenberg
Chapter 17 Modulation of Host Programmed Cell Death Pathways by the
Intracellular Protozoan Parasite, Toxoplasma gondii — Implications for
Maintenance of Chronic Infection and Potential Therapeutic Applications
by Sandra K. Halonen
Chapter 18 HMGB1 in Cell Death
by Daolin Tang and Rui Kang
Chapter 19 Necrosis as Programmed Cell Death
by Ma. Luisa Escobar, Olga M. Echeverría and Gerardo H.
Vázquez-Nin

Preface
This book is a collection of selected and relevant research,
concerning the developments within the Cell Death field of study.
Each contribution comes as a separate chapter complete in itself
but directly related to the books topics and objectives.
The target audience comprises scholars and specialists in the
field.

Chapter 1
Autophagy in Cell Fate and Diseases
Daniel Grasso, Alejandro Ropolo and Maria I. Vaccaro
Additional information is available at the end of the chapter
http://dx.doi.org/10.5772/61553
Abstract
Autophagy pathway has been one of the hot topics during the last decade. From a
general notion about its cellular role, autophagy becomes a more sophisticated
phenomenon with significant implications in cellular homeostasis. Consequently,
autophagy represents an emerging new factor in human diseases. Despite its general
task, the bulk degradation of cellular constituents during starvation settings,
autophagy possesses important cross talk and interrelationships with several cellular
processes such as apoptosis and senescence, among others. This entire panorama
gives us a complex but exciting scenario. Consequently, with the aim of encompassing
the whole spectrum, in this chapter, we review three main topics: autophagy as a
cellular process; autophagy in cell fate; and autophagy in disease. We discuss the
emerging role of selective type of autophagy to avoid apoptosis or necrosis and the
novel relationship between autophagy and senescence to understand the real extent
that autophagy pathway has over cell fate. Finally, we briefly describe the current
trends on autophagy in human pancreatic diseases and its role in cancer cell metab‐
olism.
Keywords: VMP1, zymophagy, senescence, acute pancreatitis, pancreatic cancer
1. Introduction
Autophagy is a highly regulated cellular pathway for degrading long-lived proteins and is the
only known pathway for clearing cytoplasmic organelles. Autophagy is a major contributor
to maintain cellular homeostasis and metabolism.
Autophagy is an evolutionarily conserved and highly regulated lysosomal pathway that
degrades macromolecules (e.g., proteins, glycogen, lipids, and nucleotides) and cytoplasmic