Cell Biology and Translational Medicine, Volume 5: Stem Cells: Translational Science to Therapy PDF
Preview Cell Biology and Translational Medicine, Volume 5: Stem Cells: Translational Science to Therapy
Advances in Experimental Medicine and Biology 1144 Cell Biology and Translational Medicine Kursad Turksen Editor Cell Biology and Translational Medicine, Volume 5 Stem Cells: Translational Science to Therapy Advances in Experimental Medicine and Biology Cell Biology and Translational Medicine Volume 1144 SubseriesEditor KursadTurksen Moreinformationaboutthissubseriesathttp://www.springer.com/series/15838 Kursad Turksen Editor Cell Biology and Translational Medicine, Volume 5 Stem Cells: Translational Science to Therapy Editor KursadTurksen(Retired) OttawaHospitalResearchInstitute Ottawa,ON,Canada ISSN0065-2598 ISSN2214-8019 (electronic) AdvancesinExperimentalMedicineandBiology ISSN2522-090X ISSN2522-0918 (electronic) CellBiologyandTranslationalMedicine ISBN978-3-030-17588-7 ISBN978-3-030-17589-4 (eBook) https://doi.org/10.1007/978-3-030-17589-4 #SpringerNatureSwitzerlandAG2019 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeor part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations,recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway, andtransmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,or bysimilarordissimilarmethodologynowknownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthis publication does not imply, even in the absence of a specific statement, that such names are exemptfromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthors,andtheeditorsaresafetoassumethattheadviceandinformationin thisbookarebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remainsneutralwithregardtojurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG. Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Preface InthisnextvolumeintheCellBiologyandTranslationalMedicineseries,we continuetoexplorethepotentialutilityofstemcellsinregenerativemedicine. Thechaptersinthisvolumecoverarangeoftopicsinthearea,frombiological functionofstemcellsintranslationalstudiestotissueandorganregeneration andrestorationoffunctioninclinicalsettings.Whatallofthechaptershavein common is a focus on both the advances and the challenges in this rapidly evolvingfield. IremainverygratefultoPeterButler,EditorialDirector,andMeranLloyd- Owen, Senior Editor, for their ongoing support of this series that we have embarkedupon. I would also like to acknowledge and thank Sara Germans-Huisman, Assistant Editor, for her outstanding efforts in getting the volume to the productionstages. A special thank you also goes to the production crew for their work in generatingthevolume. Finally,Ithankthecontributorsnotonlyfortheirsupportoftheseriesbut alsofortheireffortstocaptureboththeadvancesandremainingobstaclesin theirareasofresearch.Iamgratefulfortheirefforts,andtrustreaderswillfind theircontributionsinterestingandhelpful. Ottawa,CA,Canada KursadTurksen v Contents TherapeuticCardiacPatchesforRepairingtheMyocardium. . . . 1 BenjaminW.StreeterandMichaelE.Davis HumanInducedPluripotentStemCellsintheCurative TreatmentofDiabetesandPotentialImpedimentsAhead. . . . . . . 25 NidheeshDadheechandA.M.JamesShapiro CRISPR/Cas9forSickleCellDisease:Applications,Future Possibilities,andChallenges. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 SelamiDemirci,AlexisLeonard,JuanJ.Haro-Mora,NaoyaUchida, andJohnF.Tisdale PhotoresponsiveHydrogelswithPhotoswitchableStiffness: EmergingPlatformstoStudyTemporalAspects ofMesenchymalStemCellResponsestoExtracellular StiffnessRegulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 DavidRichards,JoeSwift,LuShinWong, andStephenM.Richardson CellularComplexityattheInterface:ChallengesinEnthesis TissueEngineering. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 IsabelCalejo,RaquelCosta-Almeida,andManuelaE.Gomes InducedPluripotentStemCellsinDiseaseModelling andRegeneration. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 BurcuTalugandZeynepTokcaer-Keskin StemCellsfortheOromaxillofacialArea:Couldtheybea promisingsourceforregenerationindentistry?. . . . . . . . . . . . . . 101 AyşegülMendi,HacerUlutürk,MustafaSancarAtaç, andDervişYılmaz StemCellsDerivedfromDentalTissues. . . . . . . . . . . . . . . . . . . . 123 SafaAydinandFikrettinŞahin vii viii Contents ANovelVirtueinStemCellResearch:ExosomesandTheir RoleinDifferentiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 HüseyinAbdik,EzgiAvsarAbdik,AyşenAslıHızlıDeniz, PakizeNeslihanTaşlı,andFikrettinŞahin MesenchymalStemCellsasRegulatorsofCarcinogenesis. . . . . . . 147 TahaBartuHayal,BinnurKıratlı,HaticeBurcuŞişli,FikrettinŞahin, andAyşegülDoğan Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 Contributors Ezgi Avsar Abdik Department of Genetics and Bioengineering, Faculty of EngineeringandArchitecture,YeditepeUniversity,Istanbul,Turkey Hüseyin Abdik Department of Genetics and Bioengineering, Faculty of EngineeringandArchitecture,YeditepeUniversity,Istanbul,Turkey Mustafa Sancar Ataç Faculty of Dentistry, Department of Oral and MaxillofacialSurgery,GaziUniversity,Ankara,Turkey Safa Aydin Department of Genetics and Bioengineering, Faculty of Engineering,YeditepeUniversity,İstanbul,Turkey Isabel Calejo 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Head- quarters of the European Institute of Excellence on Tissue Engineering and RegenerativeMedicine,Guimarães,Portugal ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal RaquelCosta-Almeida 3B’sResearchGroup,I3Bs–ResearchInstituteon Biomaterials, Biodegradables and Biomimetics, University of Minho, Head- quarters of the European Institute of Excellence on Tissue Engineering and RegenerativeMedicine,Guimarães,Portugal ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal Nidheesh Dadheech Alberta Diabetes Institute, University of Alberta, Edmonton,Alberta,Canada MichaelE.Davis WallaceH.CoulterDepartmentofBiomedicalEngineer- ing, Emory University and Georgia Institute of Technology, Atlanta, GA, USA Selami Demirci Cellular and Molecular Therapeutics Branch, NHLBI/ NIDDK,NationalInstitutesofHealth,Bethesda,MD,USA CellularandMolecularTherapeuticsBranch,NationalHeart,LungandBlood Institute,Bethesda,MD,USA ix x Contributors AyşenAslıHızlıDeniz HealthInstitutesofTurkey,TurkishCancerInstitute, Istanbul,Turkey Ayşegül Doğan Department of Genetics and Bioengineering, Faculty of Engineering,YeditepeUniversity,İstanbul,Turkey Manuela E. Gomes 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Head- quarters of the European Institute of Excellence on Tissue Engineering and RegenerativeMedicine,Guimarães,Portugal ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal TheDiscoveriesCentreforRegenerativeandPrecisionMedicine,Headquar- tersatUniversityofMinho,Avepark,Guimarães,Portugal Juan J. Haro-Mora Cellular and Molecular Therapeutics Branch, NHLBI/ NIDDK,NationalInstitutesofHealth,Bethesda,MD,USA TahaBartuHayal DepartmentofGeneticsandBioengineering,Facultyof Engineering,YeditepeUniversity,Istanbul,Turkey Zeynep Tokcaer-Keskin Faculty of Arts and Sciences, Department of MolecularBiologyandGenetics,AcibademMehmetAliAydinlarUniversity, Istanbul,Turkey Binnur Kıratlı Department of Genetics and Bioengineering, Faculty of Engineering,YeditepeUniversity,İstanbul,Turkey Alexis Leonard Cellular and Molecular Therapeutics Branch, NHLBI/ NIDDK,NationalInstitutesofHealth,Bethesda,MD,USA Ayşegül Mendi Faculty of Dentistry, Department of Basic Sciences, Gazi University,Ankara,Turkey David Richards Division of Cell Matrix Biology and Regenerative Medi- cine,SchoolofBiologicalSciences,FacultyofBiology,MedicineandHealth, University of Manchester, Manchester Academic Health Science Centre, Manchester,UK StephenM.Richardson DivisionofCellMatrixBiologyandRegenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre,Manchester,UK Fikrettin Şahin Department of Genetics and Bioengineering, Faculty of EngineeringandArchitecture,YeditepeUniversity,Istanbul,Turkey A. M. James Shapiro Clinical Islet Transplant Program, Alberta Diabetes Institute,UniversityofAlberta,Edmonton,AB,Canada DepartmentofSurgery,UniversityofAlberta,Edmonton,AB,Canada CanadianNationalTransplantResearchProgram,Edmonton,AB,Canada
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