Cation Flux Across Biomembranes

433 Pages·1979·10.508 MB·English

by  Yasuo Mukohata (Eds.)

ACADEMIC PRESS RAPID MANUSCRIPT REPRODUCTION
The Proceedings of a Symposium on "Cation Flux across
Biomembranes" Sponsored by the Japan Bioenergetics
Group, Held September 10-13, 1978 at the
Inter-University Seminar House of Kansai in Kobe, Japan
CATION FLUX
ACROSS BIOMEMBRANES
Edited by
Yasuo Mukohata
Department f Biolog
o y
Faculty of Science
Osaka University
Toyonaka, Japan
Lester Packer
Membrane Bioenergetics Croup
and
Department of Physiology-Anatomy
University of California
Berkeley, California
ACADEMIC PRESS
NEW YORK SAN FRANCISCO LONDON 1979
A Subsidiary of Harcourt Brace Jovanovich, Publishers
COPYRIGHT © 1979, BY ACADEMIC PRESS, INC.
ALL RIGHTS RESERVED.
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ACADEMIC PRESS, INC.
Ill Fifth Avenue, New York, New York 10003
United Kingdom Edition published by
ACADEMIC PRESS, INC. (LONDON) LTD.
24/28 Oval Road, London NW1 7DX
Library of Congress Cataloging in Publication Data
International Symposium on Cation Flux across
Biomembranes, Kobe, Japan, 1978.
Cation flux across biomembranes.
Sponsored by Japan Bioenergetics Group.
1. Membranes (Biology)—Congresses. 2. Cations-
Congresses. 3. Ion flow dynamics—Congresses.
I. Mukohata, Yasuo, Date II. Packer, Lester.
III. Japan Bioenergetics Group. IV. Title.
QH601.I534 1978 574.8'75 79-11934
ISBN 0-12-511050-2
PRINTED IN THE UNITED STATES OF AMERICA
79 80 81 82 9 8 7 6 5 4 3 2 1
Contributors
Numbers in parentheses indicate the pages on which authors' contributions begin.
ABE, HIROSHI (179), First Department of Medicine, Cardiology Division,
Osaka University School of Medicine, Osaka, Japan
AKOWITZ, ALFRED A. (103), Department of Medicine, University of Con-
necticut, Farmington, Connecticut
ALEXANDRE, ADOLFO (343), Department of Physiological Chemistry, The
Johns Hopkins University School of Medicine, Baltimore, Maryland
ANZAI, KAZUNORI (105), Faculty of Pharmaceutical Sciences, The Uni-
versity of Tokyo, Tokyo, Japan
ARAKAKI, NAOKATU (355), Faculty of Pharmaceutical Sciences, Univer-
sity of Tokushima, Tokushima, Japan
AZZONE, GIOVANNI F. (331), C.N.R. Unit for the Study of Physiology of
Mitochondria and Institute of General Pathology, University of
Padova, Padova, Italy
BACCARINI-MELANDRI, ASSUNTA (219), Institute of Botany, University
of Bologna, Bologna, Italy
BALTSCHEFFSKY, MARGARETA (209), Department of Biochemistry, Ar-
rhenius Laboratory, University of Stockholm, Stockholm, Sweden
BARRABIN, HECTOR (67), Departamento de Quimica Bioldgica, Facultad
de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos
Aires, Argentina
BÄUERLEIN, EDMUND (357), Abteilung Naturstoffchemie, Max-Planck-
Institut fur medizinische Forschung, Heidelberg, Fed. Rep. Germany
BAUM, HAROLD (371), Department of Biomedical Chemistry, Faculty of
Medicine, University of Nagoya, Nagoya, Japan; University of Lon-
don, London, U.K.
BEVEVINO, L. H. (51), Department of Physiology, Institute of Biomedical
Sciences, University of Sao Paulo, Sao Paulo, Brazil
BOLL, WERNER (89), Abteilung Physiologie, Max-Planck-Institut für
medizinische Forschung, Heidelberg, Fed. Rep. Germany
CARMELI, CHANOCH (249, 417), Department of Biochemistry, The
George S. Wise Center of Life Sciences, Tel-Aviv University, Tel-
Aviv, Israel; also Membrane Bioenergetics Group, University of
California, Berkeley, California
XI
Contributors
XII
CHANCE, BRITTON (377), Johnson Research Foundation, University of
Pennsylvania, Philadelphia, Pennsylvania
CRIDDLE, RICHARD S. (399), Department of Biochemistry and
Biophysics, University of California, Davis, California
Dl VIRGILIO, F. (331), C.N.R. Unit for the Study of Physiology of
Mitochondria and Institute of General Pathology, University of
Padova, Padova, Italy
DUPONT, YVES (141), Laboratoire de Biophysique Moleculaire et Cel-
lulaire, Departement de Recherche Fondamentale, C.E.N.G., Gre-
noble, France
EYTAN, ESTHER (409), Department of Biology, Technion — Israel Institute
of Technology, Haifa, Israel
FERNANDES, D. T. (51), Department of Physiology, Institute of Biomedi-
cal Sciences, University of Sao Paulo, Sao Paulo, Brazil
FLEISCHER, SIDNEY (193), Department of Molecular Biology, Vanderbilt
University, Nashville, Tennessee
FROEHLICH, JEFFREY P. (101), Laboratory of Molecular Aging, National
Institute of Aging, NIH, Baltimore, Maryland
FUTAI, MASAMITSU (291), Department of Microbiology, Faculty of
Pharmaceutical Sciences, Okayama University, Okayama, Japan
GARRAHAN, PATRICIO J. (67), Departamento de Quimica Bioldgica,
Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires,
Buenos Aires, Argentina
GUTMAN, MENACHEM M. (249), Department of Biochemistry, The
George S. Wise Center of Life Sciences, Tel Aviv University, Tel
Aviv, Israel
HARA, YUKICHI (21), Department of Biochemistry, School of Medicine,
Tokyo Medical and Dental University, Tokyo, Japan
HAROLD, FRANKLIN M. (301), Division of Molecular and Cellular Biol-
ogy, National Jewish Hospital and Research Center, and Depart-
ments of Biochemistry and Microbiology, University of Colorado
Medical School, Denver, Colorado
HATTORI, AKIMASA (355), Faculty of Pharmaceutical Sciences, Univer-
sity of Tokushima, Tokushima, Japan
HIGUTI, TOMIHIKO (355), Faculty of Pharmaceutical Sciences, Univer-
sity of Tokushima, Tokushima, Japan
HIRATA, HAJIME (279), Department of Biochemistry, Jichi Medical
School, Minamikawachi-machi, Tochigi, Japan
HOMAREDA, HARUO (29), Department of Biochemistry, Kyorin Univer-
sity School of Medicine, Mitaka, Tokyo, Japan
HORENSTEIN, ALBERTO (67), Departamento de Quimica Biologica,
Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires,
Buenos Aires, Argentina
HORIO, TAKEKAZU (243), Division of Enzymology, Institute for Protein
Research, Osaka University, Suita, Osaka, Japan
Contributors xiii
IIDA, SHOICHI (41), Department of Pharmacology, School of Dentistry,
Hokkaido University, Sapporo, Japan
IKEGAMI, AKIRA (139), The Institute of Physical and Chemical Research,
Wako, Saitama, Japan
IKEMOTO, NORIAKI (77), Department of Muscle Research, Boston
Biomedical Research Institute; and Department of Neurology, Har-
vard Medical School, Boston, Massachusetts
ISHIMOTO, MAKOTO (275), Department of Chemical Microbiology, Fac-
ulty of Pharmaceutical Sciences, Hokkaido University, Sapporo,
Japan
ITOH, SHIGERU (229), Department of Biology, Faculty of Science,
Kyushu University, Fukuoka, Japan
ITSAK, FANNY (377), Johnson Research Foundation, University of
Pennsylvania, Philadelphia, Pennsylvania; Department of
Biochemistry, Weizmann Institute of Science, Rehovot, Israel
JOHNSTON, RICHARD (399), Department of Biochemistry and
Biophysics, University of California, Davis, California
KAGAWA, YASUO (279), Department of Biochemistry, Jichi Medical
School, Minamikawachi-machi, Tochigi, Japan
KAKUNO, T. (243), Division of Enzymology, Institute for Protein Re-
search, Suita, Osaka, Japan
KANAZAWA, HIROSHI (291), Department of Microbiology, Faculty of
Pharmaceutical Sciences, Okayama University, Okayama, Japan
KANAZAWA, TOHRU (127), Department of Biochemistry, Asahikawa
Medical College, Asahikawa, Japan
KASAI, MICHIKI (167), Department of Biophysical Engineering, Faculty
of Engineering Science, Osaka University, Toyonaka, Osaka, Japan
KATABAMI, FUMIO (127), Department of Biochemistry, Asahikawa Med-
ical College, Asahikawa, Japan
KATAOKA, RYOICHI (139), The Institute of Physical and Chemical Re-
search, Wako, Saitama, Japan
KATSUMATA, KAZUO (371), Department of Biomedical Chemistry, Fac-
ulty of Medicine, University of Nagoya, Nagoya, Japan
KAWAKITA, MASAO (119), The Institute of Medical Science, The Univer-
sity of Tokyo, Tokyo, Japan
KAZIRO, YOSHITO (119), The Institute of Medical Science, The Univer-
sity of Tokyo, Tokyo, Japan
KIRINO, YUTAKA (105), Faculty of Pharmaceutical Sciences, The Univer-
sity of Tokyo, Tokyo, Japan
KLINGENBERG, MARTIN (387), Institut für Physikalische Biochemie der
Universität München, München, Fed. Rep. Germany
KOBAYASHI, HIROSHI (301), Research Institute for Chemobiodynamics,
Chiba University, Chiba, Japan
KOBAYASHI, KAZUO (191), Department of Neurochemistry, Tokyo Met-
ropolitan Institute for Neurosciences, Fuchu, Tokyo, Japan
XIV Contributors
KOBAYASHI, KUNIHIKO (275), Department of Chemical Microbiology,
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo,
Japan
KOBAYASHI, MASANAO (371), Department of Biomedical Chemistry, Fac-
ulty of Medicine, University of Nagoya, Nagoya, Japan
KODAMA, TAKAO (161), Department of Pharmacology, Juntendo
University School of Medicine, Tokyo, Japan
KOMETANI, TADAATSU (167), Department of Biophysical Engineering,
Faculty of Engineering Science, Osaka University, Toyonaka, Osaka,
Japan
KONISHI, TETSUYA (399, 417), Membrane Bioenergetics Group, Univer-
sity of California, Berkeley, California; Department of Radiochemis-
try and Biology, Niigata College of Pharmacy, Niigata, Japan
KRAB, KLAAS (321), Department of Medical Chemistry, University of Hel-
sinki, Helsinki, Finland
KUREBAYASHI, NAGOMI (161), Department of Pharmacology, Juntendo
University School of Medicine, Tokyo, Japan
KURODA, YOICHIRO (191), Department of Neurochemistry, Tokyo Met-
ropolitan Institute for Neurosciences, Fuchu, Tokyo, Japan
KUZUYA, TSUNEHIKO (179), First Department of Medicine, Cardiology
Division, Osaka University School of Medicine, Osaka, Japan
LACAZ-VIEIRA, FRANCISCO (51), Department of Physiology, Institute of
Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
LANYI, JANOS K. (417), NASA Ames Research Center, Moffett Field,
California
LEHNINGER, ALBERT L (343), Department of Physiological Chemistry, The
Johns Hopkins University School of Medicine, Baltimore, Maryland
LIFSHITZ, YAEL (249), Department of Biochemistry, The George S. Wise
Center of Life Sciences, Tel Aviv University, Tel Aviv, Israel
LUNDIN, ARNE (209), Department of Biochemistry, Arrhenius Labora-
tory, University of Stockholm, Stockholm, Sweden
MAKINOSE, MADOKA (89), Abteilung Physiologie, Max-Planck-Institut
für Medizinische Forschung, Heidelberg, Fed. Rep. Germany
MANDEL, FREDERIC (101), Department of Pharmacology and Cell
Biophysics, University of Cincinnati College of Medicine, Cincinnati,
Ohio
MASAMOTO, KAZUMORI (229), Department of Biology, Faculty of Sci-
ence, Kyushu University, Fukuoka, Japan
MATSUI, HIDEO (29), Department of Biochemistry, Kyorin University
School of Medicine, Mitaka, Tokyo, Japan
MATSUURA, KATSUMI (229), Department of Biology, Faculty of Science,
Kyushu University, Fukuoka, Japan
MclNTYRE, J. OLIVER (193), Department of Molecular Biology, Vander-
bilt University, Nashville, Tennessee
Contributors xv
MEHLHORN, ROLF J. (417), Membrane Bioenergetics Group, University
of California, Berkeley, California
MELANDRI, BRUNO A. (219), Institute of Botany, University of Bologna,
Bologna, Italy
MICONI, M. (331), C.N.R. Unit for the Study of Physiology of Mitochon-
dria and Institute of General Pathology, University of Padova,
Padova, Italy
MUKOHATA, YASUO (261), Department of Biology, Faculty of Science,
Osaka University, Toyonaka, Osaka, Japan
NAKAMURA, JUN (125), Biological Institute, Faculty of Science, Tohoku
University, Sendai, Japan
NAKAO, MAKOTO (21), Department of Biochemistry, School of
Medicine, Tokyo Medical and Dental University, Tokyo, Japan
NAKASE, YUZO (377), Johnson Research Foundation, University of
Pennsylvania, Philadelphia, Pennsylvania; Department of Physiol-
ogy, Wakayama Medical School, Wakayama, Japan
NAKASIMA, SETUKO (355), Faculty of Pharmaceutical Sciences, Univer-
sity of Tokushima, Tokushima, Japan
NELSON, NATHAN (409), Department of Biology, Technion—Israel Insti-
tute of Technology, Haifa, Israel
NIIMI, SINGO (355), Faculty of Pharmaceutical Sciences, University of
Tokushima, Tokushima, Japan
NISHI, NOZOMU (243), Division of Enzymology, Institute for Protein Re-
search, Suita, Osaka, Japan
NISHIMURA, MITSUO (229), Department of Biology, Faculty of Science,
Kyushu University, Fukuoka, Japan
OGAWA, YASUO (161), Department of Pharmacology, Juntendo Univer-
sity School of Medicine, Tokyo, Japan
OHKUMA, TAKA'AKI (105), Faculty of Pharmaceutical Sciences, The
University of Tokyo, Tokyo, Japan
OHMORI, FUMIO (179), First Department of Medicine, Cardiology Divi-
sion, Osaka University School of Medicine, Osaka, Japan
OHNISHI, S. TSUYOSHI (163), Department of Biological Chemistry and
Department of Anesthesiology, Hahnemann Medical College,
Philadelphia, Pennsylvania
OZAWA, TAKAYUKI (371), Department of Biomedical Chemistry, Faculty
of Medicine, University of Nagoya, Nagoya, Japan
PACKER, LESTER (399, 417), Membrane Bioenergetics Group, University
of California, Berkeley, California
PILARSKA, MARIA (193), Department of Molecular Biology, Vanderbilt
University, Nashville, Tennessee
POST, R. L. (3), Department of Physiology, Vanderbilt University Medical
School, Nashville, Tennessee
POZZAN, T. (331), C.N.R. Unit for the Study of Physiology of Mitochon-
xvi Contributors
dria and Institute of General Pathology, University of Padova,
Padova, Italy
PROBST, IRMELIN (417), Membrane Bioenergetics Group, University of
California, Berkeley, California
QUINTANILHA, ALEXANDRE T. (417), Membrane Bioenergetics Group,
University of California, Berkeley, California
RABON, EDD (53), Laboratory of Membrane Biology, University of
Alabama Medical Center, Birmingham, Alabama
REGA, ALCIDES F. (67), Departamento de Quimica Biologica, Facultad de
Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos
Aires, Argentina
REYNAFARJE, BALTAZAR (343), Department of Physiological Chemistry,
The Johns Hopkins University School of Medicine, Baltimore, Mary-
land
ROSSI, JUAN P. (67), Departamento de Quimica Biologica, Facultad de
Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos
Aires, Argentina
SACCOMANI, GAETANO (53), Laboratory of Membrane Biology, Univer-
sity of Alabama Medical Center, Birmingham, Alabama
SACHS, GEORGE (53), Laboratory of Membrane Biology, University of
Alabama Medical Center, Birmingham, Alabama
SAITO, AKITSUGU (193), Department of Molecular Biology, Vanderbilt
University, Nashville, Tennessee
SCHERRER, PETER (417), Membrane Bioenergetics Group, University of
California, Berkeley, California
SCHWARTZ, ARNOLD (101), Department of Pharmacology and Cell
Biophysics, University of Cincinnati College of Medicine, Cincinnati,
Ohio
SHIBATA, TOSHIYUKI (139), The Institute of Physical and Chemical Re-
search, Wako, Saitama, Japan
SHIEH, PAUL K. (399, 417), Membrane Bioenergetics Group, University
of California, Berkeley, California
SHIGEKAWA, MUNEKAZU1 (103), Department of Medicine, University of
Connecticut, Farmington, Connecticut; Department of Biochemis-
try, Asahikawa Medical College, Asahikawa, Japan
SHIMIZU, HIROSHI (105), Faculty of Pharmaceutical Sciences, The Uni-
versity of Tokyo, Tokyo, Japan
SHIMOMURA, YOSHIHARU (371), Department of Biomedical Chemistry,
Faculty of Medicine, University of Nagoya, Nagoya, Japan
SKULACHEV, VLADIMIR P. (303), Department of Bioenergetics, A. N.
Bolozersky Laboratory of Molecular Biology and Bioorganic
Chemistry, Moscow State University, Moscow, U.S.S.R.
1 Present Address: Department of Biochemistry, Asahikawa Medical College, Asahikawa, Japan.
Contributors χνιι
SOE, GILBU (243), Division of Enzymology, Institute for Protein Re-
search, Suita, Osaka, Japan
SONE, NOBUHITO (279), Department of Biochemistry, Jichi Medical
School, Minamikawachi-machi, Tochigi, Japan
SUGIYAMA, YASUO (261), Department of Biology, Faculty of Science,
Osaka University, Toyonaka, Osaka, Japan
SUMIDA, MICHIHIRO (101), Department of Pharmacology and Cell
Biophysics, University of Cincinnati College of Medicine, Cincinnati,
Ohio; Department of Biochemistry, Ehime University School of
Medicine, Ehime, Japan
TADA, MICHIHIKO (179), First Department of Medicine Cardiology Divi-
sion, Osaka University School of Medicine, Osaka, Japan
TAKAGI, MICHIKO (275), Department of Chemical Microbiology, Faculty
of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
TAKAKUWA, YUICHI (127), Department of Biochemistry, Asahikawa
Medical College, Asahikawa, Japan
TAKEDA, KEIKO (299), Department of Microbiology, Faculty of Phar-
maceutical Sciences, Okayama University, Okayama, Japan
TAKISAWA, HARUHIKO (129), Department of Biology, Faculty of Sci-
ence, Osaka University, Toyonaka, Osaka, Japan
TAMAKI, TERUFUSA (41), Department of Pharmacology, School of Den-
tistry, Hokkaido University, Sapporo, Japan
TANAKA, MASASHI (371), Department of Biomedical Chemistry, Faculty
of Medicine, University of Nagoya, Nagoya, Japan
TANIGUCHI, KAZUYA (41), Department of Pharmacology, School of Den-
tistry, Hokkaido University, Sapporo, Japan
TAZAWA, HIDEAKI (41), Department of Pharmacology, School of Dentis-
try, Hokkaido University, Sapporo, Japan
TERADA, HIROSHI (365), Faculty of Pharmaceutical Sciences, University
of Tokushima, Tokushima, Japan
TRASCH, HEINZ (357), Abteilung Naturstoffchemie, Max-Planck-Institut
für Medizinische Forschung, Heidelberg, Fed. Rep. Germany
TSUCHIYA, TOMOFUSA (299), Department of Microbiology, Faculty of
Pharmaceutical Sciences, Okayama University, Okayama, Japan
VAN BRUNT, JENNIFER (301), Division of Molecular and Cellular Biology,
National Jewish Hospital and Research Center; Departments of
Biochemistry and Microbiology, University of Colorado Medical
Center, Denver, Colorado
VARANDA, W. A. (51), Department of Physiology, Institute of Biomedical
Sciences, University of Säo Paulo, Säo Paulo, Brazil
WANG, CHENG-TEH (193), Department of Molecular Biology, Vanderbilt
University, Nashville, Tennessee
WANG, TAITZER (101), Department of Pharmacology and Cell
Biophysics, University of Cincinnati College of Medicine, Cincinnati,
Ohio