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i Case Studies Within Psychotherapy Trials ii iii Case Studies Within Psychotherapy Trials Integrating Qualitative and Quantitative Methods EDITED BY DANIEL B. FISHMAN STANLEY B. MESSER DAVID J.A. EDWARDS FRANK M. DATTILIO 1 iv 1 Oxford University Press is a department of the University of Oxford. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Oxford is a registered trade mark of Oxford University Press in the UK and certain other countries. Published in the United States of America by Oxford University Press 198 Madison Avenue, New York, NY 10016, United States of America. © Oxford University Press 2017 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, by license, or under terms agreed with the appropriate reproduction rights organization. Inquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above. You must not circulate this work in any other form and you must impose this same condition on any acquirer. Library of Congress Cataloging-in-Publication Data Names: Fishman, Daniel B., editor. | Messer, Stanley B., editor. | Edwards, D. J. A., editor. | Dattilio, Frank M., editor. Title: Case studies within psychotherapy trials : integrating qualitative and quantitative methods / edited by Daniel B. Fishman, Stanley B. Messer, David J.A. Edwards, and Frank M. Dattilio. Description: Oxford ; New York : Oxford University Press, [2017] | Includes bibliographical references and index. Identifiers: LCCN 2016027783 (print) | LCCN 2016029927 (ebook) | ISBN 9780199344635 | ISBN 9780199344642 (ebook) Subjects: | MESH: Psychotherapy—methods | Research Design | Case Reports Classification: LCC RC337 (print) | LCC RC337 (ebook) | NLM WM 40 | DDC 616.89/140072—dc23 LC record available at https://lccn.loc.gov/2016027783 9 8 7 6 5 4 3 2 1 Printed by Edwards Brothers Malloy, United States of America v To Peter E. Nathan (1935–2 016), valued colleague, good friend, and innovative thinker vi As a rule, when I have heard some slight indication of the course of events I am able to guide myself by the thousands of other similar cases which occur to my memory. — Arthur Conan Doyle, “The Red- Headed League,” 1891 What treatment, by whom, is most effective for this individual with that specific problem, and under which set of circumstances? — Gordon Paul, 1967, p. 111 A public policy proposal is forwarded that no form of health intervention— physical or men- tal [including psychotherapy]—s hould be supported through third- party reimbursement and publicly supported training programs unless it has been demonstrated to be safe and effective. It is argued that randomized controlled clinical trials [RCTs] should be viewed as the most valid, though not exclusive, source of evidence. — Gerald Klerman, 1983, p. 929 EBPP [Evidence-B ased Practice in Psychology] promotes effective psychological practice and enhances public health by applying empirically supported principles of psychological assessment, case formulation, therapeutic relationship, and intervention. — APA Task Force on Evidence- Based Practice, 2006, p. 271 Common to all experts, however, is that they operate on the basis of intimate knowledge of several thousand concrete cases in their areas of expertise. Context-d ependent knowledge and experience are at the very heart of expert activity. Such knowledge and expertise also lie at the center of the case study as a research and teaching method or to put it more generally still, as a method of learning. — Bent Flyvbjerg, 2006, p. 222 A psychotherapy case formulation is a hypothesis about the causes, precipitants, and main- taining influences of a person’s psychological, interpersonal, and behavioral problems. A case formulation helps organize information about a person, particularly when that information contains contradictions or inconsistencies in behavior, emotion, and thought content. Ideally, it contains structures that permit the therapist to understand these contra- dictions and to categorize important classes of information within a sufficiently encompass- ing view of the patient. A case formulation also serves as a blueprint guiding treatment and as a marker for change. — Tracy Eells, 2007, p. 4 [In] statistical hypothesis testing, … the scientist deduces one statement (or a few state- ments) from the theory and compares that statement with many observations [across dif- ferent individuals]. If the observations tend to match the statement, … then the hypothesis is considered as confirmed. In contrast, . . . the theory- building case study strategy … com- pares many theoretically-b ased statements with correspondingly many observations [within the same individual] … [asking] how well the theory describes details of the case. … because many statements are examined … The gain in confidence in the theory from a close match may be as large as from a statistical hypothesis- testing study. — William B. Stiles, 2009, pp. 11– 12 Randomized clinical trials (RCTs) research has been touted for three decades as the gold standard for determining effective and optimal treatments in the mental health arena. Unfortunately, RCT designs have failed to advance the field of psychotherapy as much as initially expected, largely because they have not proven able clearly to identify either unique or specific treatments for different diagnostic conditions. … Aspects of treatment and patients that do distinguish among treatment effects are seldom incorporated in RCT designs because they lie outside of the realm of what are considered “interventions.” — Larry Beutler and Bryan Forrester, 2014, p. 168 vii CONTENTS Preface and Acknowledgments ix About the Editors xi Contributors xiii PART I Introduction 1. The Terrain 3 Daniel B. Fishman and David J.A. Edwards 2. Navigating the Projects 26 Daniel B. Fishman PART II The Projects 3. “Cool Kids/C hilled Adolescents”: Cognitive- Behavioral Therapy for Youth With Anxiety Disorders in Denmark 39 Mikael Thastum, Irene Lundkvist-H oundoumadi, Kristian Bech Arendt, Silke Stjerneklar, and Daniel B. Fishman Commentary: International Implementation of CBT: Universal Principles Meet Local Needs 108 Lauren J. Hoffman, Elaina A. Zendegui, and Brian C. Chu 4. The Efficacy of Interpersonal Psychotherapy – Adolescent Skills Training (IPT- AST) in Preventing Depression 119 Sarah S. Kerner and Jami F. Young Commentary: Identifying Moderators of Change From Both RCTs and Case Studies 181 Laura J. Dietz 5. Transference- Focused Psychotherapy for Adult Borderline Personality Disorder 190 Kenneth N. Levy, Kevin B. Meehan, Tracy L. Clouthier, Frank E. Yeomans, Mark F. Lenzenweger, John F. Clarkin, and Otto F. Kernberg Commentary: Complementarity and Clinical Implications in Using a Mixed- Methods Approach 246 William E. Piper and Carlos A. Sierra Hernandez viii viii CONTENTS 6. Motivational Enhancement Therapy for Increasing Antidepressant Medication Adherence and Decreasing Clinical Depression Among Adult Latinos 256 Alejandro Interian, Ariana Prawda, Daniel B. Fishman, and William M. Buerger Commentary: The Best of Both Worlds 316 John C. Norcross PART III Reflections and Next Steps 7. An Outside Perspective 327 Harold Chui, Sarah Bloch- Elkouby, and Jacques P. Barber 8. Themes and Lessons Learned 337 Daniel B. Fishman, Stanley B. Messer, David J.A. Edwards, and Frank M. Dattilio Index 363 ix PREFACE AND ACKNOWLEDGMENTS In psychotherapy research, the world of randomized clinical trials (RCTs) is one of elaborate logical designs to achieve experimental control; a focus on specific variables and discrete, normative, quantitative measures of them; a search for general laws; fidelity to therapy manuals; and extensive statistical analyses of the therapy results of groups of clients. In contrast, the world of case studies of indi- vidual psychotherapy sessions and courses of therapy is one of qualitatively rich patterns of human transactions; the narrative development of an emotionally important relationship between therapist and client; the complex interaction of a client’s personality, life history, presenting symptoms and distress, and present life situation, leading the therapist to develop a guiding case formulation and treat- ment plan; and the personality, training, and expertise of the therapist. In short, one world focuses on numbers about variables within groups, and the other world focuses on words about patterns within specific persons. Up to this point, these worlds— sometimes seeming to be more associated with the physical sciences and the humanities, respectively, than with “social science” per se—h ave not unsur- prisingly been separated, despite the fact that the methods associated with these worlds actually analyze the exact same data, consisting of psychotherapy inter- actions, and despite the fact that some mental health professionals like clinical psychologists are intensively trained in both of them. This book is based on the premise that both of these worlds are of great value in psychotherapy research. Specifically, in Chapters 3– 6 we present four psycho- therapy research projects. In each there is a combination of a formal, quantitative RCT study of randomly assigned groups; two or three systematic, in-d epth quali- tative case studies of individual clients drawn from the experimental group of the RCT; and a discussion of how the two types of knowledge emerging from the RCT study and the case studies can be integrated and synthesized, with the sum of the two types of knowledge being greater than their parts. We believe one of the strengths of this book is that we systematically bring together these two different perspectives on the same psychotherapy interactions, and that readers thus have the opportunity to immerse themselves in each, side by side, and then to join the process of exploring how these two perspectives can complement one another.

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