AcademicPressisanimprintofElsevier 525BStreet,Suite1900,SanDiego,CA92101-4495,USA 30CorporateDrive,Suite400,Burlington,MA01803,USA 32JamestownRoad,LondonNW17BY,UK Radarweg29,POBox211,1000AEAmsterdam,TheNetherlands Firstedition2010 Copyright(cid:1)2010,ElsevierInc.Allrightsreserved. Nopartofthispublicationmaybereproduced,storedinaretrievalsystem ortransmittedinanyformorbyanymeanselectronic,mechanical,photocopying, recordingorotherwisewithoutthepriorwrittenpermissionofthepublisher. PermissionsmaybesoughtdirectlyfromElsevier’sScience&TechnologyRights DepartmentinOxford,UK:phone(+44)(0)1865843830;fax(+44)(0)1865853333; email:permissions@elsevier.com.Alternativelyyoucansubmityourrequestonlineby visitingtheElsevierwebsiteathttp://elsevier.com/locate/permissions,andselecting ObtainingpermissiontouseElseviermaterial. Notice: Noresponsibilityisassumedbythepublisherforanyinjuryand/ordamagetopersonsor propertyasamatterofproductsliability,negligenceorotherwise,orfromanyuseoroperation ofanymethods,products,instructionsorideascontainedinthematerialherein.Becauseof rapidadvancesinthemedicalsciences,inparticular,independentverificationofdiagnosesand drugdosagesshouldbemade. BritishLibraryCataloguinginPublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary LibraryofCongressCataloging-in-PublicationData AcatalogrecordforthisbookisavailablefromtheLibraryofCongress ISBN:978-0-12-385061-4 ForinformationonallAcademicPresspublications visitourwebsiteatelsevierdirect.com PrintedandboundinUSA 10 11 12 10 9 8 7 6 5 4 3 2 1 Contributors Numbersinparenthesesindicatethepagesonwhichtheauthors’contributionsbegin. Cyril Auger (133) Laboratoire de Biophotonique et Pharmacologie, UMR 7213 CNRS, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France William B. Campbell (27) Department of Pharmacology and Toxicology, MedicalCollege of Wisconsin, Milwaukee, Wisconsin, USA ThierryChataigneau(133)LaboratoiredeBiophotoniqueetPharmacologie, UMR 7213 CNRS, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France Wei Chen (107) Department of Medicine and Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administra- tionMedical Center, Decatur,Georgia, USA MartineClozel(1) Actelion PharmaceuticalsLtd., Allschwil,Switzerland Richard A. Cohen (85) Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA Livius V. d'Uscio (257) Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine,Rochester, Minnesota, USA AndreasDaiber(177)II.MedizinischeKlinik,LaborfürMolekulareKardio- logie und Abteilung für Kardiologie und Angiologie Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany Sergey Dikalov (107) Department of Medicine and Division of Cardiology, EmoryUniversitySchoolofMedicineandAtlantaVeteransAdministration MedicalCenter,Decatur,Georgia,USA ix
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