Cardiovascular diseases : nutritional and therapeutic interventions

611 Pages·2013·77.3 MB·English

by  Nilanjana Maulik

Medicine
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Cardiovascular
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NuTrITIoNal and TherapeuTIC
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With cardiovascular disease remaining one of the primary causes of morbidity
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and mortality worldwide, there is a great need to further understand the molecular
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basis of this disease class and develop new therapeutic or preventative measures.
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Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents
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up-to-date information on the pathobiology of cardiovascular diseases, emphasiz- l
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ing emerging therapeutics and nutritional interventions. The book is divided into a
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four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular
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diseases.
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Part I details epidemiological studies, highlighting the extent of the clinical prob- D
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lem. Part II describes the genetic and, primarily, epigenetic modifications associ- C
ated with cardiovascular disease, including the importance of DNA methylation i
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status and the possibility of early intervention using simple dietary modifications. N s
The text also discusses histone modifications associated with disease and potential T
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therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the e
etiology and pathobiology, Part III discusses lipid regulation, micro-RNAs, emerging r a
cell-based therapies, and new receptor targets for therapeutics as well as targeted v
imaging. It also describes the link between cancer therapies and cardiomyopathy and e s
the potential of vitamin C to ameliorate this effect. N
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Part IV focuses on therapeutic and nutritional interventions, namely, stem cell ther- Io s
apies, emerging nanomedicines, and a wide range of dietary interventions. These
include general healthy diets, fruits and vegetables, botanicals, effects of specific N
compounds such as antioxidants, and discussions on garlic, curcumin, and resvera- s
trol. The text also covers lifestyle factors, emphasizing the importance of stress in the
occurrence of and meditation and yoga in the management of cardiovascular disease.
This book provides a comprehensive reference for clinicians and scientists, combining
epidemiology, prevention, and modern treatment strategies.
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Cardiovascular
Diseases
NutritioNal and therapeutic
iNterveNtioNs

Cardiovascular
Diseases
NutritioNal and therapeutic
iNterveNtioNs
eDiteD BY
Nilanjana Maulik
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
CRC Press
Taylor & Francis Group
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© 2013 by Taylor & Francis Group, LLC
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Version Date: 20130125
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This book is dedicated to my loving brothers, who gave me the
unfailing support, courage, strength, and persistence to carry out
this work and who helped me in the most difficult of times.
This book is also intended for biochemists, molecular biologists, cell
biologists, biomedical researchers, and clinical researchers.
Nilanjana Maulik, PhD, FAHA

Contents
List of Figures ...................................................................................................................................xi
Preface..............................................................................................................................................xv
Acknowledgments ...........................................................................................................................xix
Editor ..............................................................................................................................................xxi
Contributors .................................................................................................................................xxiii
Part I Epidemiological Study of Heart Disease
Chapter 1 Epidemiology of Cardiovascular Disease ....................................................................3
Salim S. Abunnaja and Juan A. Sanchez
Part II Epigenetic Modifications in arterial
and Heart Diseases
Chapter 2 Epigenetics of Atherosclerosis: Current Insights and Future Perspectives ................21
Lucia Migliore and Maria Grazia Andreassi
Chapter 3 Genetic and Epigenetic Basis of Myocardial Ischemia and
Reperfusion Injury: Protection by Dietary Antioxidants and
Chromatin-Modifying Compounds ............................................................................35
Tom C. Karagiannis, Katherine Ververis, and Paul V. Licciardi
Chapter 4 Attenuation of Myocardial Ischemia-Reperfusion Injury by Probiotic Bacteria .......61
Paul V. Licciardi, Katherine Ververis, Zheng Q. Toh, and Tom C. Karagiannis
Part III Cardiovascular Disease
Chapter 5 Lipid Regulation of Cardiac Ion Channels in Heart Disease .....................................77
Lixia Yue, Zhichao Yue, and Jia Xie
Chapter 6 Arginine, Tetrahydrobiopterin, and Nitric Oxide in Myocardial Protection ...........101
Murugesan Velayutham, Lawrence J. Druhan, and Arturo J. Cardounel
Chapter 7 Role of Toll-Like Receptors in Myocardial Ischemia/Reperfusion Injury ..............123
Tuanzhu Ha, Li Liu, Jim Kelley, David Williams, and Chuanfu Li
vii
viii Contents
Chapter 8 Aging, Nutrients, and Endogenous Stem Cell Populations ......................................143
Ewa K. Zuba-Surma, Harold Elias, and Buddhadeb Dawn
Chapter 9 Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis ..............163
Hongyan Zhu and Guo-Chang Fan
Chapter 10 Doxorubicin-Induced Cardiomyopathy and Benefits from Vitamin C ....................187
Ana Ludke, Gauri Akolkar, Gunjan Bajpai, Neelam Khaper,
and Pawan K. Singal
Chapter 11 Hypoxic Preconditioning of Stem Cells to Treat Myocardial Infarction .................199
Simi M. Chacko and Periannan Kuppusamy
Chapter 12 Diabetes-Associated Cardiomyopathy and Cell Therapy ........................................211
Edith Hochhauser, Michael Morozov, and Michael Arad
Part IV Nutritional and Other therapeutic
Interventions for CVD
Chapter 13 Pluripotent Stem Cell Therapy for Cardiac Regeneration .......................................235
Kiwon Ban, Jaemin Byun, Sangsung Kim, Sukwon Koh, and Young-Sup Yoon
Chapter 14 Nanotechnology and Cardiovascular Diseases ........................................................255
Kannan Badri Narayanan and Natarajan Sakthivel
Chapter 15 Heart-Healthy Diet: “The Art and Science of Perfecting the Plate” ........................277
S. Sivasankaran
Chapter 16 Nutritional Therapy in the Treatment of Oxidative-Stress-Induced
Heart Disease ...........................................................................................................309
Yen-Chun Ho, Meng-Ling Wu, and Shaw-Fang Yet
Chapter 17 Therapeutic Strategies for Metabolic Syndrome and Lifestyle-Related Disease .....325
Hajime Otani
Chapter 18 Alcohol and Heart Health: Is the Preconditioning Effect of Wine Drinking
Related to Alcohol-Induced Changes in Cellular Fatty Acid Profile? .....................365
Joël de Leiris, Stéphane Tanguy, and François Boucher