Cardiology Board Review Cardiology Board Review RamdasG.Pai UniversityofCaliforniaRiversideSchoolofMedicine California,USA PadminiVaradarajan LomaLindaUniversityMedicalCenter California,USA SudhaM.Pai LomaLindaUniversityMedicalCenter California,USA Thiseditionfirstpublished2018 ©2018JohnWiley&SonsLtd Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyform orbyanymeans,electronic,mechanical,photocopying,recordingorotherwise,exceptaspermittedbylaw.Adviceonhow toobtainpermissiontoreusematerialfromthistitleisavailableathttp://www.wiley.com/go/permissions. TherightofRamdasG.Pai,PadminiVaradarajan,andSudhaM.Paitobeidentifiedastheauthorsofthisworkhasbeen assertedinaccordancewithlaw. 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LibraryofCongressCataloging-in-PublicationData: Names:Pai,RamdasG.,author.|Varadarajan,Padmini,author.|Pai,Sudha M.,1958-author. Title:Cardiologyboardreview/byRamdasG.Pai,PadminiVaradarajan,Sudha M.Pai. Description:Hoboken,NJ:Wiley,2017.|Includesindex.| Identifiers:LCCN2017026562(print)|LCCN2017028086(ebook)|ISBN 9781118699003(pdf)|ISBN9781118699010(epub)|ISBN9781118699027(pbk.) Subjects:|MESH:HeartDiseases|ExaminationQuestions Classification:LCCRC669.2(ebook)|LCCRC669.2(print)|NLMWG18.2|DDC 616.1/20076–dc23 LCrecordavailableathttps://lccn.loc.gov/2017026562 Coverimages:inset–©RichHobson/Gettyimages;main–©asiseeit/Gettyimages CoverdesignbyWiley Setin10/12ptWarnockProbyAptaraInc.,NewDelhi,India 10 9 8 7 6 5 4 3 2 1 Contents Preface ix HistoryandPhysicalExamination 1 RamdasG.Pai Electrocardiography 13 RamdasG.PaiandSudhaM.Pai ChestX-RayinCardiology 51 PadminiVaradarajanandRamdasG.Pai StressTestingandRiskStratificationofAsymptomaticSubjects 80 PadminiVaradarajanandRamdasG.Pai Echocardiography 95 RamdasG.PaiandPadminiVaradarajan CardiacMagneticResonanceImaging 150 PadminiVaradarajanandRamdasG.Pai CardiacComputedTomography 172 RamdasG.Pai CardiacCatheterization 199 PrabhdeepS.Sethi AcuteCoronarySyndromes 210 RamdasG.Pai ChronicCoronaryArteryDisease 229 PadminiVaradarajan HeartFailure,Transplant,LeftVentricularAssistDevices,Pulmonary Hypertension 245 RamdasG.Pai Cardiomyopathies 270 RamdasG.PaiandPadminiVaradarajan vi Contents Hypertension 288 PadminiVaradarajanandRamdasG.Pai DiabetesMellitus 298 PadminiVaradarajan Lipids 305 PadminiVaradarajanandRamdasG.Pai ValvularHeartDisease 318 RamdasG.Pai AdultCongenitalHeartDisease 351 PadminiVaradarajanandRamdasG.Pai PericardialDiseases 376 RamdasG.Pai AorticDiseases 385 AhmedShafterandAshishMukherjee CarotidandVertebralArteryDisease 403 PrabhdeepS.Sethi PeripheralVascularDisease 416 AhmedShafterandAshishMukherjee CardiacArrhythmias 435 SudhaM.Pai PacemakersandDefibrillators 463 SudhaM.Pai CardiacMasses 468 PadminiVaradarajan SystemicDisordersAffectingtheHeart 501 RamdasG.Pai InterdisciplinaryConsultativeCardiology 505 RamdasG.Pai HeartDiseaseandPregnancy 515 PadminiVaradarajanandRamdasG.Pai RacialandGenderDisparities 521 SudhaM.PaiandRamdasG.Pai Contents vii PharmacologicalPrinciplesofCardiacDrugs 524 ChristopherHauschildandLilyYam Anticoagulation 535 PadminiVaradarajan AspirinandAntiplateletTherapy 547 ChristopherHauschildandLilyYam StatisticalConcepts 553 RamdasG.Pai Genetics 562 PadminiVaradarajan CardiacEmergenciesandResuscitation 565 RamdasG.Pai Index 571 Preface Thisbookisaverycomprehensivereviewofallmajortopicsincardiologywithaninten- tiontohelpthosepreparingforinitialandrecertificationexamsincardiologyandthose whowanttoreviewcardiologyinaneasy-to-dofashion.Itisacompilationofover1300 questionsencompassingallthetopicsincardiology.Thishasbeeneditedbyaninter- nationallyacclaimed teachingphysicianwithanexpertiseinallaspects ofcardiology. The book is organized in a question-and-answer format and is divided into easy-to- followchaptersrelatedtodifferentareasofcardiovascularmedicine.Theanswersare explainedindetailandareaccompaniedbyreferencestomajortrialsincardiologyand guidelines, and some clinical pearls where applicable. The explanations are clear and evidencebased.Thebookhighlightsaspecialsectiononelectrocardiogramswhichare ofhighresolution.Theanswerstothequestionsaregivenindepth,whichwillallowthe examineestoprepareforthissectionandtaketheexamwithgreaterconfidenceasthis sectionisscoredseparatelyfromthemainexam.Thechaptersonimaginghaveques- tionsrelatingtochestX-ray,cardiaccomputedtomography,echo,stressecho,cardiac magneticresonanceimaging,nuclearstresstesting,andsoon.Thebookalsodealswith questionsrelatingtotopicsnotusuallyencounteredinsimilarbooks:forexample,racial disparitiesinmedicine,cardiacemergencies,andsoon.Thebookalsofacilitatescritical reviewofcardiovascularmedicinetoenhanceone’sdiagnosticandtherapeuticskills. History and Physical Examination .. A25-year-oldwomanhasa2/6ejectionsystolicmurmurbestheardinthesecond left intercostal space with normal S1. The S2 is split during inspiration, and P2 intensityisnormal.Noapicalorparasternalheave.Themurmurdiminishesduring expirationandstandingup.Whatisthemurmurlikelydueto? A. Physiologicalornormal B. Atrialseptaldefect(ASD) C. Bicuspidaorticvalve D. Hypertrophicobstructivecardiomyopathy(HOCM) .. A29-year-oldpregnantwomanwasfoundtoahaveasystolicmurmurbestheard inthesecondleftintercostalspace.Itisroughandtherewasapalpablethrillinthe sameareaandinthesuprasternalnotch.Patientisasymptomaticandhasnormal exercisetolerance.Whatisthelikelyexplanationofthemurmur? A. Pulmonarystenosis(PS) B. Normalflowmurmurduetoincreasedcardiacoutput C. Posteriormitralleafletprolapsecausinganinteriorlydirectedjet D. Mammarysouffle´ .. A22-year-oldpatienthasahypoplasticradialsideoftheforearmandfingerized thumb.Whatthismaybeassociatedwith? A. ASD C. Coarctationofaorta B. TetralogyofFallot D. Ebstein’sanomaly .. A28-year-oldmanpresentedwithahistoryofshortnessofbreathonexertion.On examination,thepulseratewas76bpmandbloodpressure(BP)126/80mmHg. Theleftventricularapexwasprominentandforceful.TheS1andS2werenormal, buttherewasa2/6ejectionsystolicmurmurbestheardinthethirdrightinter- costal space. There was no appreciable variation with respiration, but there was anincreaseinintensitywiththeValsalvamaneuverandstandingup.Itseemedto belessprominentonsquatting.Therewasnoaudibleclick.Whatisthemurmur likelydueto? A. Valvularaorticstenosis C. Mitralvalveprolapse(MVP) B. HOCM D. Innocentmurmur .. A 36-year-old asymptomatic woman was found to have a systolic murmur best heardintheapex,butalsointheaorticarea.Itwasmidtolatesystolicandwas associatedwithasharpsystolicsound.Whatisthelikelycauseofthemurmur? A. Posteriormitralleafletprolapse C. Valvularaorticstenosis B. Anteriormitralleafletprolapse D. Aorticsubvalvularmembrane .. A78-year-oldmanwithhypertensionanddiabetesmellituspresentedwithexer- tional shortness of breath of 6months’ duration. Examination revealed a 4/6 crescendo–decrescendomurmurbestheardinthesecondrightintercostalspace. CardiologyBoardReview,FirstEdition.RamdasG.Pai,PadminiVaradarajanandSudhaM.Pai. ©2018JohnWiley&Sons,Ltd.Published2018byJohnWiley&Sons,Ltd. CardiologyBoardReview Thefirstcomponentofthesecondsoundwassoft.Themurmurwasalsoheard Chapter1 alongtherightcarotidartery.Whatisthispatientlikelytohave? A. Mildaorticstenosis C. Pulmonarystenosis B. Moderateorsevereaorticstenosis D. MR .. A thrill and a continuous machinery murmur in the left infraclavicular area is indicativeofwhat? A. Patentductusarteriosus(PDA) B. Increasedflowduetoleftarmarteriovenous(AV)fistulafordialysis C. Venoushum D. PulmonaryAVfistula .. Whichofthefollowingisnotafeatureofaorticcoarctation? A. Acontinuousmurmurontheback B. Lowerbloodpressureinlegscomparedwitharm C. Radiofemoraldelay D. Pistolshotsoundsonfemoralarteries .. A22-year-oldnewlyimmigrantwomanwasreferredtohigh-riskpregnancyclinic because of clubbing and cyanosis. Examination in addition revealed a paraster- nalheave,4/6ejectionsystolicmurmurinthethirdleftintercostalspace,normal jugularvenouspressure(JVP),andoxygensaturationof75%.Whatwillyourec- ommendafterconfirmationofthediagnosis? A. Continuepregnancywithsodiumrestriction B. Continuepregnancy,butdeliverat28weeks C. Adviseterminationofpregnancy D. PerformpercutaneousASDclosureandcontinuepregnancy .. WhatisthemurmurofASD? A. Continuousduetoflowacrossthedefect B. Ejectionsystolicduetoincreasedflowacrossthepulmonaryvalve C. Mid-diastolicduetoincreasedflowacrossthetricuspidvalve D. Continuousoverlungfieldsduetoincreasedflowinlungs .. Whatisasystolicclickthatdisappearsoninspirationlikelydueto? A. Pulmonaryvalvularstenosis C. MVP B. Bicuspidaorticvalve D. Pulmonaryhypertension .. A 36-year-old woman presented with an 8-month history of progressive exer- tional dyspnea. Physical examination revealed heart rate of 74 bpm, regular, BP 126/78mmHg,nopedaledema.JVPandcarotidupstrokewerenormal.Cardiac auscultation revealed normal S1, an accentuated P2 with narrow splitting of S2, an ejection click, and a 2/6 ejection systolic murmur. What is the likely diagnosis? A. Pulmonaryhypertension C. Aorticstenosis B. PS D. ASD .. Causesofprominent“a”waveinjugularvenouspulsationsincludeallofthefol- lowingexceptwhichoption? A. PS D. Aorticstenosis B. Pulmonaryhypertension E. ASD C. Tricuspidstenosis
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