Cannabinoids and the Brain Cannabinoids and the Brain Linda A. Parker The MIT Press Cambridge, Massachusetts London, England © 2017 Massachusetts Institute of Technology All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means (including photocopying, recording, or information storage and retrieval) without permission in writing from the publisher. Set in Sabon LT Std by Toppan Best-set Premedia Limited. Printed and bound in the United States of America. Library of Congress Cataloging-in-Publication Data Names: Parker, Linda (Linda A.), author. Title: Cannabinoids and the brain / Linda Parker. Description: Cambridge, MA : The MIT Press, [2017] | Includes bibliographical references and index. Identifiers: LCCN 2016030736 | ISBN 9780262035798 (hardcover : alk. paper) Subjects: LCSH: Nervous system--Degeneration--Treatment. | Cannabis--Therapeutic use. | Marijuana--Therapeutic use. Classification: LCC RM666.C266 P37 2017 | DDC 615.7/827--dc23 LC record available at https://lccn.loc.gov/2016030736 10 9 8 7 6 5 4 3 2 1 for Ernie Contents Preface ix 1 An Introduction to Cannabis 1 2 The Endocannabinoid System 19 3 Cannabinoids and Emotional Regulation 35 4 Cannabinoids and Psychosis 55 5 Cannabinoids, Learning, and Memory 67 6 Cannabinoids, Reward, and Addiction 79 7 Cannabinoids, Body Weight, Feeding, and Appetite 97 8 Cannabinoids and Nausea 107 9 Cannabinoids and Pain 123 10 Cannabinoids and Epilepsy 139 11 Cannabinoids and Neurodegenerative Disorders 149 12 Where Do We Go from Here? 163 References 177 Index 233
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