Cancer Research Official Journal of the American Association for Cancer Research 1995: Vol 55 Table of Contents

19 Pages·1995·6.7 MB·English

Contents of Volume 55
January 1, Number 1
Advances in Brief Experimental Therapeutics Tumor Biology
Development of a Humanized Disulfide-stabilized Anti-p18S4#ER2 py.g. Transcriptional Induction of the Melanocyte-stimulating Hormone Receptor
In Vivo Molecular Therapy with p53 Adenovirus for Microscopic Residual Lactamase Fusion Protein for Activation of a Cephalosporin Doxorubicin in Brain Metastases of Murine K-1735 Melanoma. Robert Radinsky, Pedro J.
Head and Neck Squamous Carcinoma. Gary L. Ciayman, Adel K. El-Naggar, Prodrug. Maria L. Rodrigues, Leonard G. Presta, Claire E. Kotts, Cindy Wirth, Beltran, Rachel Tsan, Ruodan Zhang, Roger D. Cone, and Isaiah J. Fidler.
Jack A. Roth, Wei-Wei Zhang, Helmuth Goepfert, Dorothy L. Taylor, and Ta-Jen Joyce Mordenti, Gary Osaka, Wai Lee T. Wong, Andrew Nuijens, Brent
Liu. Blackburn, and Paul Carter.
Common Expression of the Tumor Marker p-Galactose-B-|1—>-3|-N-Acetyl-
Attenuation of G2 Checkpoint Function Precedes Human Cell Immortal- Cytotoxic Activity of Chimeric Toxins Containing the Epidermal Growth p-Galactosamine by Different Adenocarcinomas: Evidence of Field Effect
ization. William K. Kaufmann, Eleni N. Levedakou, Heather L. Grady, Richard Factor-like Domain of Heregulins Fused to PES38KDEL, a Truncated Re- Phenomenon. Abulkalam M. Shamsuddin, George T. Tyner, and Guang Yu
S. Paules, and Gretchen H. Stein combinant Form of Pseudomonas Exotoxin. Ako Kihara and Ira Pastan. Yang.
Altered p53 Status Correlates with Differences in Sensitivity to Radiation- Relationship of DNA Topoisomerase Ila and £ Expression to Cytotoxicity of Cyclocreatine Accumulation Leads to Cellular Swelling in C6 Glioma
induced Mutation and Apoptosis in Two Closely Related Human Lympho- Antineoplastic Agents in Human Acute Lymphoblastic Leukemia Cell Lines. Multicellular Spheroids: Diffusion and One-Dimensional Chemical Shift
blast Lines. Fen Xia, Xi Wang, Yi-Han Wang, Ngan-Ming Tsang, David W. Greg A. Brown, J. Peter McPherson, Lie Gu, David W. Hedley, Robert Toso, Nuclear Magnetic Resonance Microscopy. Yae! S. Schiffenbauer, Catherine
Yandell, Karl T. Kelsey, and Howard L. Liber. Kathryn L. Deuchars, Melvin H. Freedman, and Gerald J. Goldenberg. Tempel, Rinat Abramovitch, Gila Meir, and Michal Neeman.
p53 and Retinoid Chemoprevention of Oral Carcinogenesis. Scott M. Combined Radioimmunotherapy and Radiotherapy of Human Colon Car-
Lippman, Dong M. Shin, J. Jack Lee, John G. Batsakis, Reuben Lotan, cinoma Grafted in Nude Mice. Franz Buchegger, Anamaria Rojas, Angelika Spontaneous Melanoma Formation in Nonhybrid Xiphophorus. Angelika
Michael A. Tainsky, Walter N. Hittelman, and Waun Ki Hong. Bischof Delaloye, Charles-André Vogel, René-Olivier Mirimanoff, Philippe Schartl, Barbara Malitschek, Steven Kazianis, Richard Borowsky, and Manfred
Coucke, Lin-Quan Sun, Serge Raimondi, Julie Denekamp, André Pélegrin, Schartl.
Homozygous Deletions of the Multiple Tumor Suppressor Gene 1 in the Bernard Delaloye, and Jean-Pierre Mach.
TPPLorripoapognovrssielacsor,sc ciaootAmnina od:nro ef wt MH(ou1Hl2m.e; ac1nKu6al )ya(erqA,1 s 3t;Fraprona1cdn1y k)t oCHmyi.ant s oT.gMo eymnxlDeioatnviisidcod n ,LG Ai.n paanloWdysa slaikMrseac.rr o,tm iaJnWe nenLiaia nfvediDrn u .a RnCo,.u nEdKm niilgC hetlA,l. AREPuenxcvptcreiier,-ss MsieAioslonsen se.son afg neAtdrlhre ea s sIOaZnlnavidmagrpsoeoinrv ueic nQliuPe,aho tettSinredoorentge yi,po I en CGhaaoipbfbar iciTtceirlioalonnal is,f oFofiar bnbmUdie, rd oM kaEirHnniruaoimsc aea D nel AR neFiRcicohebsirpsnotoib.o,l r a sMtGase rncbeoy TtVLoeeh r roHonuimmcbaao nsM poorVanandsdiciu,nl aSrMy lovdEiunedl oaLttahemebslei ratlH, u mCYeavllenss . BLFreregaranascnted s,c Aad JeeaInnno cacMraidcrohncaei,l n oJFmoeiaadn a rtCM,e alrlae n dA dLChehweaasnlitloaenl,
PD.a meMl.a FlJe.t cRheenrw. ick, Paola Dal Cin, Herman Van Den Berghe, and Christopher Tparteiabitlmietny t Coomf pElxepxe riNomnernetsatlr icGtleido blCaysttootomxai c wiTt h Celal HuLimnae.n AlMeasjsoarnd rHai sCteoscaonmo-, PErxepsreenscsei ona nodf WIhnsitcahbi liCthya raocft eRreipzeetsit iRvies k Elfeorm eCnotlso niicn SCeanqcueern.c esJ intghseh anA ltCehreend,
Microsatellite Instability and Other Molecular Abnormalities in Non-Smail Sophie Visonneau, and Daniela Santoli. Barbara G. Heerdt, and Leonard H. Augenlicht.
Cell Lung Cancer. Kwun M. Fong, Paul V. Zimmerman, and Peter J. Smith. Characterization of the M, 190,000 Multidrug Resistance Protein (MRP) in
iEMzanerddco emlbelyto r iaAa nltd (ri6Pa;o,1l 4y)ap(nspd 2 1wGi;atqvh2 i4n)Po r eTdFraoaamn. silnoacnatt ioSnt.r omRaolb erCtoam pVoannenin,t SAursea nnCah arMaacrtrears-, DRDroouuggge-lrsa esGl .e cWDt.ee edl Leoyea ,n d DavTirda nsRf.e ctHiepdf nerH,u mJaanne TE.u mMoarck ieC,e llsS.u saKnu rtP . CC.. CAollmeq,u isatn,d PEMihntehcnahoenltclye,p de P aPuolfh oHtT.uo pmSratorndi uckcMltaa nldi,Rg enpaaannidtr : R MobeIetlrsa t nRooTl.m ea J oihnCn esltlohsne. DDaNvAi d DHa. maHgatet-oRne, siDsatviadn ceL.
TPhaepa dNoopvoeull osA,c tivSautsiaonn Ao.f ARBidLg e,b y CaFtuhseiroinn e to Aa. n Beotusc-hreerla,t edC arGoeln e,S toTcEkLi.n g,P anaonsd Immunology TMoulmeocru leS up(pCre-sCsAiMv)e Roini e Porfo satna teA ndCraorgceinn-roemgau laCteelld REepivtehaelleida l bCyel l SeAndshee siaonnd
Leanne M. Wiedemann. RHeeapcattiovcietlyl ultao r B CCaelrlc inoomoa. n —rio PiriHseip, atCiatrilso C FaVbirrisu,s CPioerrelu igPir oTtoeniiunta to , AWnatnigs,e nsDea viAd pp!r. oKalcehiense.r manJ,e r-NTsgounyge n HsTi.e hV,a n,W eiapndi ngS ueL-uHo,w a WeLiint.a o Song, Yang
Epstein-Barr Virus in Epithelial Cell Tumors: A Breast Cancer Study. Daniela Vitulli, Giorgio te Edmondo Falleti, Fabio Gonano, Pierino
Louise G. Labrecque, Diana M. Barnes, Ian S. Fentiman, and Beverly E. Griffin. Ferroni, Vinicio Gasparini, and Ettore Bartoli.
Multistep Tumor Targeting in Nude Mice Using Bispecific Antibodies and a Announcements
Regular Articles GTaolmloigurma pChhye.l atJeo chSeuint abSlceh uhfomra chIemrm,u noGsacbionrt igKlriavpéhnyyi , wiRtohn alPdo sitMraotny s,E miMsasriioonn GFeutrutrreu deA nnEulaioln MCeaentcienrg sR eosfe atrhceh AAAwCaRr d
Stadler, Thomas Regiert, Harald Hauser, Josef Doll, Wolfgang Maier-Borst, and NCI Minority Travel Awards
Margot Zoller. Workshop on Histopathobiology of Cancer
Biochemistry and Biophysics Workshop on Molecular Biology in Clinical Oncology
Identification of Meth A Sarcoma-derived Class | Major Histocompatibility Workshop on Methods in Clinical Cancer Research
Cellular Processing of Copper-67-labeled Monoclonal Antibody chCE7 by Complex-associated Peptides Recognized by a Specific cps* Cytotoxic T AACR Special Conferences in Cancer Research
Human Neuroblastoma Cells. Ilse Novak-Hofer, Hans Peter Amstutz, Helmut Lymphocyte. Maria Antonia Frassanito, Jose 1. Mayordomo, Rita M. DeLeo, Recert Death
R. Micke, Rolf Schwarzbach, Kurt Zimmermann, Jean-Jacques Morgenthaler, Walter J. Storkus, Michael T. Lotze, and Albert B. DeLeo Calendar of Events
and P. August Schubiger.
Molecular Biology and Genetics
Carcinogenesis Erratum
A Prognostic Model of Recurrence and Death in Stage I Non-Small Cell IEnxspurleisn-sleidk e inG Prroiwmtahr y FaHcutmora n 1 S(aIrGcFo-m1a)s . ReActeop tSoerksy,i -OItGuF,- 1R,o bearntd S.I GBFel-l2, CAarrea M. Koi et al., 54: 4308—4312, 1994.
Lung Cancer Utilizing Presentation, Histopathology, and Oncoprotein Ex- Ohashi, Michael Pollak, and Irene L. Andrulis.
pression. David H. Harpole, Jr., James E. Herndon, Il, Walter G. Wolfe, J. Dirk
Iglehart, and Jeffrey R. Marks. Genetic Evidence for an Independent Origin of Multiple Preneoplastic and Instructions for Author:
Neoplastic Lung Lesions. Gabriella Sozzi, Monica Miozzo, Ugo Pastorino,
Dietary Chlorophyllin Is a Potent Inhibitor of Aflatoxin By Hepatocarcino- Silvana Pilotti, Rosangela Donghi, Monica Giarola, Laura De Gregorio, Giacomo
genesis in Rainbow Trout. Vibeke Breinholt, Jerry Hendricks, Cliff Pereira, Daniel Manenti, Paolo Radice, Fabiola Minoletti, Giuseppe Della Porta, and Marco A.
Arbogast, and George Bailey. Pierotti.
January 15, Number 2
Advances in Brief Regular Articles Experimental Therapeutics
Basic Fibroblast Growth Factor Does Not Protect against Classical Radia-
Human Tumor Gangliosides Inhibit Murine Immune Responses in Vivo. tion Pneumonitis in Two Strains of Mice. Patricia Grace Tee and Elizabeth L.
Ruixiang Li, Nelly Villacreses, and Stephan Ladisch Carcinogenesis Travis.
Clonal Expansion and Attenuated Apoptosis in Wilms’ Tumors Are Asso- Fibers Released from Cigarette Filters: An Additional Health Risk to the
ciated with p53 Gene Mutations. Nabeel Bardeesy, J. Bruce Beckwith, and Jerry Smoker? John L. Pauly, Heather A. Allaart, Manuel |. Rodriguez, and Richard J. Insulin-like Growth Factor I (IGF-I) and the IGF-I Receptor Prevent
Pelletier. Streck. Etoposide-induced Apoptosis, Christian Sell, Renato Baserga, and Raphael Rubin.
Tumor Progression and Loss of Heterozygosity at 5q and 18q in Non-Small Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Natu- Normocalcemic Effect of Gallium Nitrate in a Hypercalcemic Rat Model.
Cell Lung Cancer. Kwun M. Fong, Paul V. Zimmerman, and Peter J. Smith. rally Occurring Plant Phenolic Compound. Chinthalapally V. Rao, Abraham Juan-Ru Lin, thor Bekersky, Nita S. Brown, Seymour Mong, Francis Lee, Robert A.
Rivenson, Barbara Simi, and Bandaru S. Reddy. Newman, and Dah Hsi Ho.
Localization of Tumor Suppressor Loci on Chromosome 9 in Primary
Human Renal Cell Carcinomas. Paul Cairns, Kaori Tokino, Yolanda Eby, and Change of the Sequence Specificity of Daunorubicin-stimulated Topo-
David Sidransky. Clinical investigations isomerase II DNA Cleavage by Epimerization of the Amino Group of the
Correlation of the in Situ Detection of Polymerase Chain Reaction-amplified Sugar Moiety. Giovanni Capranico, Eugenio Butelli, and Franco Zun.no.
Unscheduled Activation of Cyclin B1/Cdc2 Kinase in Human Promyelocytic Metalloproteinase Complementary DNAs and Their Inhibitors with Prog-
Leukemia. TsCuenlel hiLrion e ShHimLi6z0u, CePlatlrsi ckU ndMe. rgOo'iCnognn orA,p opKtuorsti s W.I ndKuohcne,d abnyd DYNveAs nSoimssiisr , inF idCeelr vViaclaela , Caanrdc iDneobmoar.ah GLe.r aFrrde ncJh.. Nuovo, Phyllis B. MacConnell, Aylin Immunology
Pommier. Rapid and Specific Uptake of Anti-Tac Disulfide-stabilized Fv by Interleu-
Cholecystokinin-B/Gastrin Receptor: A Novel Molecular Probe for Human kin-2 Receptor-bearing Tumors. Keith O. Webber, Robert J. Kreitman, and Ira
Enhanced Efficacy of Combinations of Retinoic Acid- and Retinoid X Re- Small Cell Lung Cancer. Yoshinobu Matsumori, Nobuyuki Katakami, Mitsuhiro Pastan.
ceptor-selective Retinoids and a-Interferon in Inhibition of Cervical Carci- to, Taizo Taniguchi, Nobuko [wata, Tomoaki Takaishi, Kazuo Chihara, and
noma Cell Proliferation. Reuben Lotan, Marcia |. Dawson, Chang-Chun Zou, Toshimitsu Matsui. Hemotoxicity by Prolonged Etoposide Administration to Mice Can Be Pre-
Ling Jong, Dafna Lotan, and Chang-Ping Zou. vented by Simultaneous Growth Factor Therapy. Gerald de Haan, Christoph
Engel, Bert Dontje, Markus Loeffler, and Willem Nijhof.
bcl-2 and p53 Oncoprotein Expression during Colorectal Tumorigenesis. Endocrinology
aFnrda nkB eAr.n aSridn icLreovpien,. San Bao Ruan, Karen R. Cleary, L. Clifton Stephens, J. Jack Lee, Cmhaanr acBtreearsitz atCiaonnc ero f aBnodm bTehseiinr/ GRaesltartiino-nrsehliep astion Sgt erPoeipdt idRee ceRpetcoerp toErxpsr eisns iHonu.- Molecular Biology and Genetics
Gabor Halmos, James L. Wittliff, and Andrew V. Schally. NAD(P)H:Quinone Oxidoreductase Expression and Mitomycin C Resist-
Structure of the Human MLH1/ Locus and Analysis of a Large Hereditary ance Developed by Human Colon Cancer HCT 116 Cells. Su-shu Pan, Gerald
Nonpolyposis Colorectal Carcinoma Kindred for mlh1 Mutations. Richard D. Exon 5 Deletion Variant Estrogen Receptor Messenger RNA Expression in L. Forrest, Steven A. Akman, and Li-Tai Hu.
Kolodner, Nigel R. Hall, James Lipford, Michael F. Kane, Paul T. Morrison, Paul J. Relation to Tamoxifen Resistance and Progesterone Receptor/pS2 Status in
Finan, John Burn, Pamela Chapman, Christine Earabino, Elizabeth Merchant, Human Breast Cancer. Angela A. 1. Daffada, Stephen R. D. Johnston, lan E. DNA Repair in the MYC and FMS Proto-oncogenes in Ultraviolet Light-
and D. Timothy Bishop Smith, Simone Detre, Nicholas King, and Mitchell Dowsett. irradiated Human HL60 Promyelocytic Cells during Differentiation. Ange!
L. Islas and Philip C. Hanawalt.
Perspectives in Cancer Research Epidemiology Genetic Changes in Primary and Recurrent Prostate Cancer by Compara-
Antiepileptic Treatment and Risk for Hepatobiliary Cancer and Malignant tive Genomic Hybridization. Tapio Visakorpi, Anne H. Kallioniemi, Ann-
The Insulin-like Growth Factor I Receptor: A Key to Tumor Growth? Lymphoma. Jgrgen H. Olsen, Gabi Schulgen, John D. Boice, Jr., John Whysner, Christine Syviinen, Eija R. Hyytinen, Ritva Karhu, Teuvo Tammela, Jorma J.
Renato Baserga. Lois B. Travis, Gary M. Williams, Frank B. Johnson, and James O'D. McGee. Isola, and Olli-P. Kallioniemi.
CONTENTS OF VOLUME 55
Splice Site Mutation in the Glucocorticoid Receptor Gene Causes Resistance 392 nar Proliferation Kinetics in Human Tumor Xenografts Measured with 434 The Human Tumor Cell-derived Collagenase Stimulatory Factor (Renamed
to Glucocorticoid-induced Apoptosis in a Human Acute Leukemic Cell Line. jodeoxyuridine Labeling and Flow Cytometry: A Study of Heterogeneity EMMPRIN) Is a Member of the Immunoglobulin Superfamily. Chitra
Elisabeth M. C. Strasser-Wozak, Rosa Hattmannstorfer, Monika Hala, Bernd L. os a Comparison between Different Methods of Calculation and Other Biswas, Ying Zhang, Rosana DeCastro, Huiming Guo, Toshiya Nakamura,
Hartmann, Michael Fieg], Stephan Geley, and Reinhard Kofler. Proliferation Measurements. Luis A. Perez, David Dombkowski, Jimmy Efird, Hiroaki Kataoka, and Kazuki Nabeshima.
Frederic Preffer, and Herman D. Suit.
Promyelocytic Leukemia-specific PML—Retinoic Acid a Receptor Fusion
354 bci-2 Deficiency in Mice Leads to Pleiotropic Abnormalities: Accelerated Protein Interferes with Erythroid Differentiation of Human Erythroleuke-
LHSYhuyyikpmmiophophinikoogo,im deK nYiottsCaahemtliuiltro aakn,aD, e HaSitahshnia ndtto o i,nD K ioTsTnotdhohorryhtum,e u dsT as nuSdjm aiaYnmloudlsr ha,iSI hpniltdTeeaeesk tnei,Tsn sheui.j P iomTlSoayhtkcioayn.hjs ait sihcKi a,m KaiTddeant,se uyo,A kiNHhoaidikaor, tPHFPararosanorsnegacmonrioiuestns si e.sJ .i-R oCiahnntr d eseMtp,ae omnTfmsd ueannretyHo o rMSTampsuiounmnidoe,l -redK aeCCzpeuaelhrlnic dkiLoeni nnotUemt. as uHmaiCye,Ala dloMse a nsNioaancke aa VnrTiitcasrthioein m,oa imtnRs aoua b, e Crlatno dCnM ea.llA l nsTt Saoypnloionnrt-o,o m2RHUaoi-9lsaD3ia e7clo kbKaxa5,y C 6e-2MBlpala -ssrcG Cbielaulurtlloacls io., AsA repFdGo reuplaatEtnl,cont esihXseiaucrsnoon c eLGMIsiarn, rid igMuSanycenarinen,soid i, nt CiebUvMsiy.gat oryMe T eTuolePmfase tmosaHcer,hdu l,meM ,aaN arenntacd anr doZ HsFbiiPaissigtgei rion loiFicGea,yiw ctu tiTsoiceerz p.ip “aena oH .P e—Bleaircbcei .r i,
Tumor Biology
Pathogenesis of Ascites Tumor Growth: Vascular Permeability Factor, Vas- Sigma-1 and Sigma-2 Receptors Are Expressed in a Wide Variety of Human Meeting Report
cular Hyperpermeability, and Ascites Fluid Accumulation. Janice A. Nagy, and Rodent Tumor Cell Lines. Bertold J. Vilner, Christy S. John, and Wayne D.
Elizabeth M. Masse, Kemp T. Herzberg, Michelle S. Meyers, Kiang-Teck Yeo, Bowen. 450 Keystone Symposium on Complex Carbohydrates in Biology and Medicine:
Tet-Kin Yeo, Tracy M. Sioussat, and Harold F. Dvorak. Cancer. Barbra Rodriguez-Thomas.
41 := Involvement of the Very Late Antigen 4 Integrin on Melanoma in Interleu-
369 Pathogenesis of Ascites Tumor Growth: Fibrinogen Influx and Fibrin Ac- kin 1-augmented Experimental Metastases. Angela Garofalo, Renato G. S.
cumulation in Tissues Lining the Peritoneal Cavity. Janice A. Nagy, Michelle Chirivi, Chiara Foglieni, Rod Pigott, Roberta Mortarini, Ines Martin-Padura, Andrea Announcements
S. Meyers, Elizabeth M. Masse, Kemp T. Herzberg, and Harold F. Dvorak. Anichini, Andy J. Gearing, Francisco Sanchez-Madrid, Elisabetta Dejana, and Future Annual Meetings of the AACR
Raffaella Giavazzi. Workshop on Histopathobiology of Cancer
376 Pathogenesis of Ascites Tumor Growth: Angiogenesis, Vascular Remodel- Workshop on Molecular Biology in Clinical Oncology
iMDnvogor,rg aaaknn., d KSetmropm aT . FHoerrmzabetrigo,n Eline atnhoer PJe. rMiatnosneeaalu , LiAnninn g.M . JaDnvicoer akA,. Naangdy ,H aErlolledn SF.. 420 CPNeirlcolht oolTnay sp eNE-u.s cpPlereceaierfci e,c MKaFigisnnheogreteri pcr Ki. nRtBeihsnaokgo noao,nf c eSMt eepnShipenneg citRor.o msWaci lolpaiyna.md s , MCeaatnnadir nignMaae rakl L . DC.e FllNloosrb ilaebn.,y CWARaeAolcCreeRknn stdh aorSD ppe eaocftoi hna E lv MeenCttoshn ofderse nicne sC liinni cCaal ncCearn ceRre searcRhe search
Quantitative Distinction of Cisplatin-sensitive and -resistant Mouse Fibro-
sarcoma Cells Grown in Multicell Tumor Spheroids. K. R. Frenzel, R. M. 428 Hyaluronan on the Surface of Tumor Cells Is Correlated with Metastatic
Saller, J. Kummermehr, and S. Schultz-Hector. Behavior. Lurong Zhang, Charles B. Underhill, and Lieping Chen. 457 Author Index
February 1, Number 3
Advances in Brief Autocrine Growth Stimulation by Transforming Growth Factor a@ in Molecular Biology and Genetics
Asbestos-transformed Rat Mesothelial Cells. Chery! Walker, Jeffrey Everitt,
45 << ee Coexpression of the Multidrug Resistance Genes MRP and mdr! Patrice C. Ferriola, Wendy Stewart, James Mangum, and Edilberto Bermudez. 62 e NSpeegcaiteisv e SpeGcriofiwctihty . CMo.n trMoelsn ilo,f VH.e LKrau toCveslklisk h,b yC .C oPincncoelxii, nC . GEelnfegsa:ng , COo.n nTerxauibn,
uRoagetr eGa. eDre ePl reoy,dI nugcSeturss a Bnr ioncP k., VC P.-D a1Cvo6il ed, ( ERat.n odpH oiMspafinxdeewr)e,-l sleB loeSyeceht eesdSt. e dN.Hi 6el9s enS, maPlelt er CeBl.l JeLnusenng, EUArvsnaiolnlugda ,t ai BoRenat tty oTfPr .a CcWhhieelakmilon psrEoepni,vt ehnSehtleiieavllea CSeAhlalg remCnaut,ls t uarinnde DVTierfrafnneorsnef notEr .m aSMtteeiceolhena. n iAsstsiacy . CJlualisas eTs. KDH.eu tmeWicaltnli eocnkL ey,o mf paChnhdo rcoyH.mt eoYssa omamUsasalik nig.B rMeualktaigceol oirn tFhle uoIrceesnc-e1nqc1e2 iRn egSiitoun Hoyfb rIindtiezrapthiaosne
46. jo Cytotoxic T Cells Overcome BCR-ABL-mediated Resistance to Apoptosis. with Tandem DNA Probes. Doppalapudi S. Rupa, Leslie Hasegawa, and David A.
Ephraim J. Fuchs, Atul Bedi, Richard J. Jones, and Allan D. Hess. Tamoxifen Induces Short-Term Cumulative DNA Damage and Liver Tu- Eastmond.
mors in Rats: Promotion by Phenobarbital. Philip Carthew, Elizabeth A.
467 Identical Allelic Loss on Chromosome 11q13 in Microdissected in Situ and Martin, lan N. H. White, Francesco De Matteis, Richard E. Edwards, Barbara M. p53 Abnormalities and Genomic Instability in Primary Human Breast Car-
Invasive Human Breast Cancer. Zhengping Zhuang, Maria J. Merino, Rodrigo Dorman, Robert T. Heydon, and Lewis L. Smith. cinomas. Jorunn E. Eyfjérd, Steinunn Thorlacius, Margret Steinarsdottir, Rut
Chuaqui, Lance A. Liotta, and Michael R. Emmert-Buck. Valgardsdottir, Helga M. Ogmundsdottir, and Kesara Anamthawat-Jonsson.
47 Nw AARi dteaS npoDececimaforipcco iunlAoofsmr,ai caPoanfo- ltAohm ee TroLinuicnoaglno. , ECamnYadPn uISeAel]ya m oTuParioo lliyJ,.m GoFarrrtpaenh.ci ess m CroIfst s,A sJsuolciei aTtreadc hmwaint,h aMnodd ulInahtiobrit s InhiGbliutcso coNrutcilEceonairdd -oiTncrdarunciseidn oocAalptoiopogtn oys oifs tihne thGel uHcuomcoarnt icLoeiud keRmeicce pCteolrl 652 NlKuuMln2air3t a-CkHaa1 r cHiianrnoosdme a, N. Man2Ndo3 r-TiHaok 2al sihzMiu keasS,s uzeMunakgsiae.a rk i RONkAa , ATbaukanfduamn:c eN omian ,H uAmtsaunsh i HNeapkaatzoacweal,-
474 MiSenitmdaoelnpl eonCtd.he inWoatnt ekiiPnnr so,sL toaactnaidlc i JzoaThtuni monoS .r aLnazdCoe .lC li sLpilnaetsi.n RYeuksiihsitraon ceK oinnd oH, umSahniu -MHionrgm onKueo-, LS.i nAel nCemEriM, aCn-d7 . GeNroarlede nL iMtw.a cRko.b ertson, Peter V. N. Bodine, Tin-Chen Hsu, Emad MwYiuottkhao t iSNoaanrksca tosmouafrt uto,h ied a npd5 T3rT aaGkneastnfoeos rhima antdIi shopin5k a3w iaPn.r oRteenianl OCveelrl exCparrecsisnioomna s.A reH iAdsesakoic iaOtdead,
Epidemiology Effect of a Mutation at Tyrosine 950 of the Insulin-like Growth Factor I
478 MAS.ce ttVihivotaottlrsie,o xna Btrbiegy-i tatC-eaP rhHbeaonaxygyl-apZleeiapnntoii,ud ea:sT heo OmpAat-siM moiBnzaoaecrt,li oonnYoa lloa fn dAMan ettiDhb.o otdMryoe nxtaCetojean njouP,g raotadenr.d u gFK .a rfMion.r 557 CAh rCoamsaet-iCdon tBrorle akSst uidn y Lyomfp hNoocnyrtaensd oomf LuDinsgt riCbauntcieorn Coafs eBsl. eoXmiyfcenign -iWun,d ucTe.Cd. RLie,c eapndt orR enoant ot heB asGerrogwa.t h and Transformation of Cells. Masahiko Miura, Shiwei
Huennekens. Hsu, John F. Annegers, ChristopherI .A mos, JohnJ .F ueger, and Margaret R. Spitz. p53-independent Induction of WAFI/CIP!] in Human Leukemia Cells Is
Correlated with Growth Arrest Accompanying Monocyte/Macrophage Dif-
482 Pharmacokinetics of 9-cis-Retinoic Acid in the Rhesus Monkey. Peter C. 562 Age at Establishment of Helicobacter pylori Infection and Gastric Carci- ferentiation. Wei Zhang, Luigi Grasso, Craig D. McClain, Anne M. Gambel, Ying
Adamson, Robert F. Murphy, Karen A. Godwin, Edgar H. Ulm, and Frank M. Balis. noma, Gastric Ulcer, and Duodenal Ulcer Risk. Martin J. Blaser, P. H. Chyou, Cha, Salvatore Travali, Albert B. Deisseroth, and W. Edward Mercer.
and Abraham Nomura.
Aipnodpetpienn,d enat PArpootepitno siDse riinv eHdu mfarno m OsCtheiocskaernc omAan emCielal s. ViSrhuis-,M eiI nZdhuucaensg , p5A3v-i Tumor Biology
Shvarts, Hans van Ormondt, Aart G. Jochemsen, Alex J. van der Eb, and Mathieu Experimental Therapeutics 675 High Rates of Thioredoxin Secretion Correlate with Growth Arrest in
H. M. Noteborn. Multifactorial Resistance to 5,10-Dideazatetrahydrofolic Acid in Cell Lines Hepatoma Cells. Anna Rubartelli, Neris Bonifaci, and Roberto Sitia.
490 Evidence for a Multifocal Origin of Papillary Serous Carcinoma of the Derived from Human Lymphoblastic Leukemia CCRF-CEM. Giuseppe 66 Host Organ Specifically Determines Cancer Progression. Shinji Togo, Hiroshi
Peritoneum. Michael G. Muto, William R. Welch, Samuel Chi-Ho Mok, Christina Pizzorno, Barbara A. Moroson, Arlene R. Cashmore, Orsolina Russello, Shimada, Tetsuro Kubota, A. R. Moossa, and Robert M. Hoffman.
A. Bandera, Paula M. Fishbaugh, Sai-Wah Tsao, Ching C. Lau, Howard M. Jennifer R. Mayer, John Galivan, Marlene A. Bunni, David G. Priest, and G. Peter
Goodman, Robert C. Knapp, and Ross S. Berkowitz. Beardsley. In Vivo Local Expansion of Clonal T Cell Subpopulations in Renal Cell
Carcinoma. Catherine Gaudin, Pierre-Yves Dietrich, Sylvie Robache, Maryvonne
493 Increased p16 Levels Correlate with pRb Alterations in Human Urothelial 574 N-[2-(2-Methyl-5-nitroimidazolyl)ethy!]-4-(2-nitroimid Be BD\ Buccd 3 Guillard, Bernard Escudier, Marie-Josée Terrier Lacombe, Anil Kumar, Frédéric
Cells. Thomas Yeager, Walter Stadler, Cassandra Belair, Jairaj Puthenveettil, (NSC 639862), a Bisnitroimidazole with Enhanced Selectivity as a Bioreduc- Triebel, and Anne Caignard.
498 OVDLlauougrrifaeimnnuaaiann, rmt yi L loFasEaiyHbs,oret i prazaoOintgoldo e ocpnFZea eulddcleRec,urhe liicca,eao rnp dtA MonaCCtrnaao etnrnhecMteliierl.nias no seme Ganr.oRgte etzronl Eiark,ioR cfaNf A.An n VaillSliaps,ea c iLeMoser reingDzheoit ,e cCtPaeamdoe llal iinnBi u,tH tuaAfmioascohn,a n x — tWaIpi inhvlCtoes rosoapmDnth.rb uouimrgnoi.er ndaeJl so hCnAf hcoeWtlm.il vooawtMtiohinseogern l aeCpnay,ynt /do MCciaEhcnnhrchaoeeamlrne c PeG.dP e- Hn4aeC5y 0h, eTmWGhioeeltnrlheaie aprmyTa :paAeS.ntu srtfDaeietrnce:n g yy,E.D f feaeLvnciedtn l goW oipfClm hlOeeixnnaa tmz aanR-od.f PIrSIgoinwasndersgueai cnsbhdteliuiy.eor, n i nEAgnot dsfu oPsAghhpoeio rnpbotMouoalsss i asmE Musotnbdeeyru, -l SiapnYthudoitunracg keoados fi YnDaAeitp foofmipeintr, eo HnttuSiiecmna a-tiinDtoi Nnr.AoL h e HuHiFkdareekakmogiim mocerO nhitt,Haa L,t- ai6nEod0ln i zYCaaebOslecultcsyhu:u rkA-iA.
50 ACeclclesl eErcattoipoinc alolfy ApEoxpptroessissi ngi n BT-rmaynbs.f oJrumraijn gB iesG raonwdt hL inFdaa ctWoorl ffB. 1-treated M1 SDeanvsiidt iJz.a tWiaoxnm anof. Human Renal Cell Carcinoma Cells to cis-Diamminedi- cSKeo.lp itVdo. r .HT ouMnm.n o. Zr. WCoejltlusk ieEwxipcrze,s sD . FGu.n cTtainogn,a lE . “BeTne-tJhoeserfe,d C.L iRgeannaudd”, TD.h rAo.m Wbailnz , Raen-d
CJRoeahcnnic perGroosdc laealsn kdi ,R Cbe Wlill IlnLiaiacnmte si.vR aitGciehooanrf dfsr,ea yn dD a|.v Siphdia p6iJI.r oNS,Ku g4Ca hrrbiEaskxteiparrn,e sDsa.in doE nd Bwaarrirnde tst,P rJL.ie msRatoelrrly i nKso.Lb zuinkg, cIBYhonostnlhaeoivrrdiloadep.aul ,ka itniY naus6mu (oRI eIKc)o eipstbhoyihr a rAanM,to in-KoIecnnlt-eoicrnhlaiel u kAikAnan mtai6tb souMd,oy n.o YcolYsohouiniyaculhk ii AOMnhitzsiuutbgaion,di y, andBo re nOjsAanamtmiiun- Meeting Reports
dDeirff eCraenncte rA. ngTiiomg eOn’iBcr iePn,a thDawvaiyds CrCahnasrtaocn,t erSiuszaen SFuupgegrlfei,c iRaoly aBnicdk neIlnlv,a sainvde ABdlraidan- In Vivo Enhanced Antitumor Activity of Carmustine [N,N’-Bis(2-chloro- 705 FDiifftfhe reHnetiidaetliboen,r gearn d CoSnefleecrteinvce e Tohne rTaapryg.e tJso hfno r S.C aBnecretrra m.R esearch: Prevention,
ILn. HVairvrios . Occurrence of p16 (MTS1) and p15 (MTS2) Alterations Preferen- eBRitutthaty ,l )D-eStN e-fRnaeinntzori osP,se ozuzGroietutala}i, a noRb oyd MoSalizfzmoiv naiPsa,to aletCtietnci,i. l iaanM da uDraRivezemigoon a,RF .u mLaSogoramelanl,iz .o RoMbaegrrtaas siB,a etGtiao,r gMi.o 71 = cGeern etSiecm inPaorl.y mForrapnkh isJ.m Goannzdal eCza.n cer Susceptibility: Fourteenth Sapporo Can-
tially in Non-Small Cell Lung Cancers. Osuke Washimi, Masaaki Nagatake,
Hirotaka Osada, Ryuzo Ueda, Takashi Koshikawa, Tsuneo Seki, Toshitada 60 ow In Vivo Antitumor Activity of Two New Seven-substituted Water-soluble
Takahashi, and Takashi Takahashi. Camptothecin Analogues. David L. Emerson, Jeffrey M. Besterman, H. Roger 716 Announcements
Brown, Michael G. Evans, Peter P. Leitner, Michael J. Luzzio, Joel E. Shaffer, Late-Breaking Research Session at the AACR Annual Meeting
Daniel D. Sternbach, David Uehling, and Alain Vuong. Future Annual Meetings of the AACR
Regular Articles Gertrude Elion Cancer Research Award
Immunology WWoorrkksshhoopp oonn HMioslteocpualtahro bBiioollooggyy oifn CCalninciecra l Oncology
Biochemistry and Biophysics 610 AMnyteil-oCmDa5 4 Cel(lIsC. AMY-i1-W)u HHausa ngA,n tJiatmuemso rA . ARcitcihvairtdys oinn, SaCnId D EllMeinc eS . wViitteht ta.H uman WAAoCrRk shoSpp ecoina l MeCtohnofderse nicne sC liinni cCala ncCearn ceRre seRaersceha rch
Translocation and Activation of Protein Kinase C by the Plasma Cell Calendar of Events
Tumor-promoting Alkane Pristane. Siegfried Janz, Klaus Gawrisch, and David Role of Natural Killer Cells in Psychosocial Stressor-induced Changes in
S. Lester. Mouse Mammary Tumor Growth. Gerald J. Rowse, Joanne Weinberg, and
Joanne T. Emerman. 719 Correction
Carcinogenesis Antibody-targeted Superantigens Induce Lysis of Major Histocompatibility S. Yuan et al., 53: 1304-1311, 1993
Metabolic Activation of N-Hydroxy Arylamines and N-Hydroxy Heterocy- Complex Class Il-negative T-Cell Leukemia Lines. Johannes thle, Ursula
clic Amines by Human Sulfotransferase(s). H-C. Chou, N. P. Lang, and F. F. Holzer, Frauke Krull, Mikael Dohisten, Terje Kalland, Dietrich Niethammer, and
Kadlubar. Giinther E. Dannecker. 720 Author Index
};}
CONTENTS OF VOLUME 55
February 15, Number 4
Advances in Brief Bioactivation of Aromatic Amines by Recombinant Human Cytochrome Immunology
P4501A2 Expressed in Ames Tester Strain Bacteria: A Substitute for Acti-
TiLzhaeocdkm aNsoe fu rLCoooobrklr,ae slVatitojimaoayn : Vo.A f JoNPs-ehmdi,iy actT raitGece nHeOon lcbAormlopoolkgi,yf icHGearlteoinou np S awSlitwteuhnd ,y .P rDoaSgnuinseoalsn isCL h.a igCnno ohLvnoi,cc ahlA,-. vDDaeotBnirgou,ni na,n bdy H eFa.M tahPeemtrme ra Ll.Gi ueaLnonrg de,r iTcJihas.ms euse NP.r eOpaakr,a tiDoavnisd. HP.. EDvaanvsi,d ZJuoysue phGyu,o , LiMlili-aSno okS. NTMIerameccmarurtonoisopnigths ha egTreFua ampcoyPtr.ro- orbg eAenan@nir etitonttrego SCDcMelhiilmcmsiei d ntI iwnsicPtahrhke , a sILGeimsog wmi-u RDnIeopes,s p eMo anSrsukyip -vpIerAnn.et esesWsrsrfii evgrehtot on, IGanprntldaeu nrsuMl l.e oTukcuRiyimnttoa e r-2L .
Louis Chesler, Susan T. Rowe, Marc B. Valentine, Hiroaki Komuro, Robert P. Young.
CBarsotdleeubre.r ry, Laura C. Bowman, P. V. Rao, Robert C. Seeger, and Garrett M CyclophosphamideC lMientiacbaolli sImn ivn eCshitlidrgeant. iSo.n Msu rray Yule, Alan V. Boddy, MoleBiocloguy alnd aGenreti cs
Expression of Nitric Oxide Synthase in Human Central Nervous System Michael Cole, Lisa Price, Ruth Wyllie, MariaJ .T asso, Andrew D. J. Pearson, and Frequent Microsatellite Alterations on Chromosome 3p in Esophageal Squa-
Tumors. Charlies S. Cobbs, Jay E. Brenman, Kenneth D. Aldape, David S. Bredt, Jeffrey R. Idle. mous Cell Carcinoma. Satoshi Ogasawara, Chihaya Maesawa, Gen Tamura, and
and Mark A. Israel. Ryoichi Satodate.
Amplification at 12qi3-14 in Human Malignant Gliomas Is Frequently Nonlinear Pharmacokinetics of Cyclophosphamide in Patients with Meta- Overexpression of DAN Gene Product in Normal Rat Fibroblasts Causes a
Accompanied by Loss of Heterozygosity at Loci Proximal and Distal to the static Breast Cancer Receiving High-Dose Chemotherapy followed by Retardation of the Entry into the S Phase. Toshinori Ozaki, Yohko Nakamura,
Amplification Site. Guido Reifenberger, Julia Reifenberger, Koichi Ichimura, and Autologous Bone Marrow Transplantation. Tian-Ling Chen, Jose L. Passos- Hideki Enomoto, Masayoshi Hirose, and Shigeru Sakiyama.
V. Peter Collins. Coelho, Dennis A. Noe, M. John Kennedy, Kraig C. Black, O. Michael Colvin, and
Androgens Induce Resistance to bci-2-mediated Apoptosis in LNCaP Pros- Louise B. Grochow. Tumor Biology
tate Cancer Cells. Guy J. Berchem, Manon Bosseler, LaVencia Y. Sugars, High Expression Level of a6 Integrin in Human Breast Carcinoma Is
H. James Voeller, Samantha Zeitlin, and Edward P. Gelmann. Endocrinology Correlated with Reduced Survival. Kay Friedrichs, Patricia Ruiz, Folker Franke,
Ingbert Gille, Hans-Joachim Terpe, and Beat A. Imhof.
Enhancement of Hyperthermic Killing in L5178Y Cells by Protease Inhib- Expression of the Messenger RNAs for Luteinizing Hormone-releasing Hor-
iNtaokrsa.m uWreai, -Gaunod HZihruo,s hSi hiSgaestaoksih.i Antoku, Shinobu Kura, Ryoji Aramaki, Katsumasa mGaobnreie le( LIHrRmeHr), Charnidst iaIntse RBeiicregpert,o rR olifn MHiiullmear,n OlOafv aOrritamna nnE,p itUhrseulliaa l PeCtearr, ciSnhoamm a.S . TZaegnzaasgc,i nD avEixdp rRe.s sFiroined lainnd eAr,s trDoocuygtlomaasCs . MCiollrerre,l aJtoensa thawni thD osAinkg,i oJgoeanne sCiasng.i arDealvliad,
Kakar, Jimmy D. Neill, Klaus-Dieter Schulz, and Giinter Emons. Mery Kostianovsky, Henry Cohen, Martin Grumet, and M. Alba Greco
CGfHoleurno mena.tih nneg J iPvzoaootnnnegd n tHGiiCaapholp,a erOalJrc-otgLseaeirpnnhiid zzaaauGtt. i iooDNnnia sgleiaoocsffh e , t ahT eJu aMnmoHaou usrLme aa iSndlu Gapewpnv,ro een Js eswaHoniir tp hMp G.e elHn-WoehLm:aio lnledIoyam,gup yl iBceDarittnos ide oatnshRsee. IAnchiidb itRieocne ptoof rA IADcSt-ivKaatpioosni. ’sW eiS-aXricnogm aG uoC,e llP arPkraoslhi feSr.a tGiiloln, afnodl lToowniyn g AnRteatkilnyo.i c tEDixaovpnir de isnsW iyTonhnfy orroodfi- dTM huotEmpaaintsth. e lpi2ail ”@C*e llIsn. duTciemso thIyn sulPi. n-Dlaiwkseo nG,r oAwdtrhia n FaRcatdourl es1c uS,e craen-d
Seizinger, and Nikolai Kley. Molecular Analysis of the Cytokine Network Involved in Cachexia in Colon
Characterization of the Functional Specificity of a Cloned T-Cell Receptor Experimental Therapeutics 2Ak6i hiAsda enoHacraardca,i noKmoau-jib eaKruinnog, MMairciek.o KAakziuyoa ma,Y asuEmmoitkoo, NNaakoafsuhmimia , MuNkaakiadbaa,
Heterodimer Recognizing the MART-1 Melanoma Antigen. David J. Cole, Biological Characterization of a Novel Antitumor Quinolone. Jacob J. Fujioka, Masayoshi Mai, Tadashi Kasahara, Kaori Fujimoto-Ouchi, Kazushige Mori,
Daniel P. Weil, Joel Shilyansky, Mary Custer, Yutaka Kawakami, Steven A. Clement, Neal Burres, Kenneth Jarvis, Daniel T. W. Chu, Joseph Swiniarski, Yutaka Tanaka, and Kouji Matsushima.
Rosenberg, and Michael I. Nishimura and Jeffrey Alder.
Characterization of the Major Sialyl-Le*-positive Mucins Present in Colon,
Colon Carcinoma, and Sera of Patients with Colorectal Cancer. Christoph
Special Lecture Prevention of Hepatic Metastasis of Human Colon Cancer by Angiogenesis Hanski, Marie-Luise Hanski, Thomas Zimmer, Dieter Ogorek, Peter Devine, and
Inhibitor TNP-470. Tatsuo Tanaka, Hiroyuki Konno, Iwao Matsuda, Satoshi Ernst-Otto Riecken.
Nakamura, and Shozo Baba.
Camptothecin and Taxol: Discovery to Clinic—Thirteenth Bruce F. Cain Antiproliferative Effect of Spermine Depletion by V-Cyclohexyl-1,3-diamin-
Memorial Award Lecture. Monroe E. Wall and Mansukh C. Wani. opropane in Human Breast Cancer Cells. Maria Huber and Richard Poulin.
Enhanced Antitumor Effects of CD20 over CD19 Monoclonal Antibodies in
a Nude Mouse Xenograft Model. Erik Hooijberg, Paul C. M. van den Berk, Johan Regulation of Apoptosis in Normal and Malignant Ovarian Epithelial Cells
Regular Articles J. Sein, John Wijdenes, Augustinus A. M. Hart, René W. de Boer, Corelis J. M. by Transforming Growth Factor B. Laura J. Havrilesky, Jean A. Hurteau, Regina
Melief, and Annemarie Hekman. S. Whitaker, Alaa Elbendary, Shu Wu, Gustavo C. Rodriguez, Robert C. Bast, Jr.,
and Andrew Berchuck.
Biochemistry and Biophysics Identification of a Point Mutation in the Folate Receptor Gene That Confers Abnormal Patterns of D-Type Cyclin Expression and Gy Regulation in
a Dominant Negative Phenotype. Rebecca B. Orr and Barton A. Kamen. Human Head and Neck Cancer. Jirina Bartkova, Jiri Lukas, Heiko Miiller,
Hepatic Glycerol Metabolism in Tumorous Rats: A 3¢ Nuclear Magnetic Michael Strauss, Barry Gusterson, and Jiri Bartek
Resonance Study. Katherine Jung-Mei Liu, Yifat Drucker, and Jehad Jarad.
Differential Effects of N-(4-Hyd heny))reti ide and Retinoic Acid on Expression of Selenium-dependent Glutathione Peroxidase in Human Breast
Purification and Characterization the Platelet-Aggregating Neuroblastoma Cells: Apoptosis versus Differentiation. }M irco Ponzoni, Paola Tumor Cell Lines. R. Steven Esworthy, Margaret A. Baker, and Fong-Fong Chu.
STMiaoakulasooeg lYyacCmoooplrroion,t eiaAnndd eTgnapok4ca4as hricE ixTnpsoruemrsuaos .e d2 6. byM ianako ToMyeotsahsitmaat,i c MoVatroiwaon t NaCkealjlsi mao,f BRooczczao,, aVnadl erPiaao loC hiGeisuas,e ppAen drMeoan taDledcoe.n si, Vito Pistoia, Lizzya Raffaghello, Carla CInadruccitnioonm a ofC eMl,l 9L2i,n0e0 0b yT yFpiber oIbVl asCtosl.l aEgrennsat seL enEgxypelr,e ssRieobnec cian Ga uSmq,u aJmosoeu sJ uaCreelz,!
Gary Clayman, Motoharu Seiki, Hiroshi Sato, and Douglas Boyd
TDSMeriirahndnayaskdrlo ro oBcx.aN yatOvgimaioaotn,y a ,m oMifanH r ictP orDsoCh3t.i-e iiMOnnug dmausbPcayhew,odas rpaHhM,iaor tonsaHohiscidey e tkSiih c1i k TuCo,ayD tioaafdlnfadye, tr ieMcKnae tsiiajSaiktu aibtNousannku ia ito,sNf i sHhHdiirLuko-rasi6whni0a g. SChe1il,ml2as5,.- MEDHifoerfnlaiataclaa,ndc oyam Jn.ad o DfM yiLktciehhnseae, es l Q VueGRinr.n ooGwLrc.iea vnreNgmra .yr aciyinan nsaC nu,l tKuWBre2et1 ty5 a2nJ .d Aabnibndo ttM,Di Xce-H.5i 2r-oJm1ai ctqsuuae glaiiSnaneis tto ,P lHTouawdmmaaasnhn,i Workshop on EukaryoMtiece tDNiAn gR epaRire pGoenrets and Gene Products. Alan R.
Effect of Inhibitors of Poly(ADP-ribose) Polymerase on the Induction of Lehmann.
Carcinogenesis GRP78 and Subsequent Development of Resistance to Etoposide. Satadal
B-2 Microglobulin Is Mitogenic to PC-3 Prostatic Carcinoma Cells and Chatterjee, Ming-Fang Cheng, Ravi B. Berger, Sosamma J. Berger, and Nathan A.
Antagonistic to Transforming Growth Factor B61 Action. David R. Rowley, Berger. Announcements
Truong D. Dang, Lauren McBride, Michael J. Gerdes, Bing Lu, and Melinda Larsen. Future Annual Meetings of the AACR
FHeatmusst-sepre cifCiHc L CYCPe3llAs7 Haanvde ASdiumlitl-asrp eciCfaipca ciCtYyP 3Ato4 AcEtxipvraetses edC aricn inCohgienneisce GtEuflrfeeec nt RdeoaMafc . 1t 1iHo0anl, li dopan-y ,B MAonutsoen yhBJe r.na yiHalnra dliDnniognp,ea -mfDiornuuegcltraogssi ec E .a nNMdeo uorrtohene, s .Ba onrdYo onBh aaNnreerusyt J r.So Aenlt lieaCnw.aa pn-, WWWooorrrkkkssshhhoooppp ooonnn HMMioe ltheocdusl tahroi nbB iiCoollilongoiygc ya l oifnC aCCnalcniecnriec ra lR esOenacroclho gy
Mycotoxins. Hisashi Hashimoto, Tetsuya Nakagawa, Tsuyoshi Yokoi, AACR Special Conferences in Cancer Research
Minoru Sawada, Susumu Itoh, and Tetsuya Kamataki. Effect of the Extent of Chelate Substitution on the Immunoreactivity and Calendar of Events
Behavior of Crocidolite Asbestos during Mitosis in Living Vertebrate Lung Biodistribution of 2IT-BAT-Lym-1 Immunoconjugates. David L. Kukis,
Epithelial Cells. Jeffrey G. Ault, Richard W. Cole, Cynthia G. Jensen, Lawrence C. Gerald L. DeNardo, Sally J. DeNardo, Gary R. Mirick, Laird A. Miers,
W. Jensen, Lori A. Bachert, and Conly L. Rieder. Douglas P. Greiner, and Claude F. Meares.
March 1, Number 5
Advances in Brief Comparative Genomic Hybridization Detects Novel Deletions and Amplifi- Clinical Investigation
cations in Head and Neck Squamous Cell Carcinomas. Michael R. Speicher,
Chris Howe, Paul Crotty, Stanislas du Manoir, José Costa, and David C. Ward. Pharmacokinetics, Biodistribution, and Dosimetry of Specific and Control
Overexpression of Cyclin D1 Correlates with Recurrence in a Group of Radiolabeled Monoclonal Antibodies in Patients with Primary Head and
Forty-seven Operable Squamous Cell Carcinomas of the Head and Neck. Neck Squamous Cell Carcinoma. Anthony Maraveyas, Nick Stafford, Gail
RWioebn tjMeincsh,a liadneds ,A lfNoincso leBtatlam . van Veelen, Augustinus Hart, Barbara Loftus, Ellen Regular Articles Rowlinson-Busza, J. Simon W. Stewart, and Agamemnon A. Epenetos.
Induction of Apoptosis in Liver Tumors by the Monoterpene Perillyl Alco- Endocrinology
hol. JeremyJ . Mills, Ravi S. Chari, IvanJ .B oyer, Michael N. Gould, and RandyL Biochemistry and Biophysics Idoxifene: Report of a Phase I Study in Patients with Metastatic Breast
Jirile. Insulin-mediated Intracellular Targeting Enhances the Photodynamic Ac- Cancer. R. Charles Coombes, Ben P. Haynes, Mitchell Dowsett, Mary Quigley,
tivity of Chiorin eg. Tamara V. Akhlynina, Andrey A. Rosenkranz, David A. Jans, Jacqueline English, lan R. Judson, Lesley J. Griggs, Gerry A. Potter, Ray McCague,
bDeyt eIcnttioenr phoafs eC DFKlNu2or esDceelnectieo nsi n iSni tTu umHoyrb ridCeilzla tiLoinn.e s Ma.n d H. PrDirmeayrliyn g,G liS.o maK. and Alexander S. Sobolev and Michael Jarman.
Bohlander, M. O. Adeyanju, and O. I. Olopade. TRradeiaotlmaebnetl edo f AHnetaidb odayn d CoNmebcki neCda ncewrit:h REexctoenrsntarlu ctRiaodni otohf eraa pTyh eorfeort ictahle Experimental Therapeutics
Early Detection of Knudson’s Two-Hits in Preneoplastic Renal Cells of the Phantom of the Larynx for Radiation Dose Calculation to Local Tissues. In Vitro Cytotoxicity of a Novel Antitumor Antibiotic, Spicamycin Deriva-
EFrkietzr KlRiamte k,M odYeaslu shbiy Ktihkeu chLia,s ePre teMr icBraondniasscshe,c tiaonnd OPkriooc eHdiunroe. . Yoshiaki Kubo, AW.n thSotnewya rtM,a raavnedy aAsg, amMeelmvnyonn MyAe. rsE,p enNeitcoks .S tafford, Gail Rowlinson-Busza, J. Simon Otigvaes, awina rHau, maYans unLourin g FuCnaanycaemra ,C eTlalt sLuion esO.h irYao, unagnd SiNka gLaehei,r oK aSzauitjoo. Nishio, Hayato
aSfutpeprr eIsosniiozni ngo f RBacdli-a2t ioMne,s seTnugmeorr RNNeAc roPsriosd ucFtacitoonr Maa,y anMde diCaetrea miAdpeo.p tosMiesi Carcinogenesis ACedleln oCvainrcuesr- meind iaa tNeudd eG eMnoeu sTeh erMaopdyel .f orB erHtu mWa. n O'HMealalde y,a ndJ r.,N eSchku -HSsqiua amCoheuns,
CWheeinc,h seJlobsea umQ.u intans, Zvi Fuks, Craig Thompson, Donald W. Kufe, and R. R. aPnhde noOtCyp/eC DaEn d 2D2i ffDeerreinvteida tiofnr omP atttheer nsL ivoef rst he ofO vaCla rcCienllo geLni-ntesr eaOtCe/d CDREat s.6 Mary R. Schwartz, and Savio L. C. Woo.
Induction of Apoptosis at Different Oxygen Tensions: Evidence That Oxy- Svetlana Radaeva and Pablo Steinberg. Dfeicftfeedr enwtiitahl WEiffledc-tTs ypoef P(-GG1l8y5c)o proro teMiunt anItn hi(bVit1o8r5s) oMnu ltNiIdHr3uTg3 TrCaelnlssp orTtrearnss.-
gen Radicals Do Not Mediate Apoptotic Signaling. Ruth J. Muschel, Eric J. Adenomas Induced by Polycyclic Aromatic Hydrocarbons in Strain A/J Carol O. Cardarelli, Ivan Aksentijevich, Ira Pastan, and Michael M. Gottesman.
BHeurmnhaanrd , GLluiios maGsar zaw,i tWh. WGiillldie-sT yMpceK enpn5a3, Eaxndp reCsasm erboenl -2.J. KLolcohy.d M. Alderson, GRMoaosrusys, eDG .a rLrSuetnto nge Br.,C oNrSertleesplohanet,ne KNawetirstinhn oaw T,iH m.e a-nWidi nlstMoeangr,rc a JtJae.m deM sas DsNR. A RaAbdindouwcitt z,L evAenltsh.o nJye ffGraelya tiA,. dEinnhea nPcheomsepnhto ryolfa s5e- FlIunohriobi-t2o'r- de5o-x(yBuernizdyilnoex ybAenntziytlu)mboarr biEtfufriicca cy Acbiye tAhce ycUlroi--
Robyn L. Castleberg, Griffith R. Harsh [V, David N. Louis, and John W. Henson. nucleoside. Osama M. Ashour, Fardos N. M. Naguib, Mohamed M. A. Khalifa,
Potential Genoprotective Role for UDP-Glucuronosyltransferases in Chem- Mahmoud H. Abdel-Raheem, Raymond P. Panzica, and Mahmoud H. el Kouni.
Loss of Heterozygosity of the BRCA/ and Other Loci on Chromosome 17q ical Carcinogenesis: Initiation of Micronuclei by Benzo(a)pyrene and
Ji.n GHruigmnaonn, PWraoeslt atSaek r,C anAcrtehru.r XT.i anPogr teGra,o ,a nAdl eKxe nZnaecthha reVk., HAolninc.i a Salkowski, David SBkeinnz o(Fieb)rpoybrleasntes . iDni anUaD P-S.G lVuiceunrnoenauo,s ylUtmrbaenrstfoe rDaesBeo-ndie,f iacnide nPtet er CGu.l tWuerlelds. Rat Immunology
Generation of Immunostimulatory Dendritic Cells from Human CD34+
Loss of the Metastatic Phenotype in Murine Carcinoma Cells Expressing an Metabolism of Polycyclic Aza-Aromatic Carcinogens Catalyzed by Four Hematopoietic Progenitor Cells of the Bone Marrow and Peripheral Blood.
Antisense RNA to the Insulin-like Growth Factor Receptor. Li Long, Raphael Expressed Human Cytochromes P450. Sarah J. Roberts-Thomson, Michael E. Helga Bernhard, Mary L. Disis, Shelly Heimfeld, Susan Hand, Julie R. Gralow, and
Rubin, Renato Baserga, and Pnina Brodt. McManus, Robert H. Tukey, Frank J. Gonzalez, and Gerald M. Holder. Martin A. Cheever.
lll
CONTENTS OF VOLUME 55
Targetingo f Xenografted Pancreatic Cancer with a New Monoclonal Anti- 1146 Mice Deficient in Both p53 and Rb Develop Tumors Primarily of Endocrine Nonrandom Chromosomal Change (Trisomy 11) in Murine Plasmacytomas
body, PAM4. David V. Gold, Rita Alisauskas, and Robert M. Sharkey. Origin. Michele Potting Hannes Vogel, Eva Y-H. P. Lee, Allan Bradley, and Induced by an ABL-MYC Retrovirus. Francis Wiener, Allen Coleman, Beverly
LawrenceA A. Mock, and Michael Potter.
Molecular Biology and Genetics 1189 Expression of Vascular Endothelial Growth Factor and Its Possible Relation
1152 TAI, a Highly Conserved Oncofetal Complementary DNA from Rat Hepa- with Neovascularization in Human Brain Tumors. Ken Samoto, Kiyonobu
Paternally Derived H/9 Is Differentially Expressed in Malignant and Non- toma, Encodes an Integral Membrane Protein Associated with Liver Devel- Ikezaki, Mayumi Ono, Tadahisa Shono, Kimitoshi Kohno, Michihiko Kuwano, and
malignant Trophoblast. Colum Walsh, Stephen J. Miller, Folke Flam, Rosemary opment, Carcinogenesis, and Cell Activation. Junsheng Sang, Yow-Pin Lim, Masashi Fukui.
A. Fisher, and Rolf Ohlsson. Marilyn Panzica, Paul Finch, and Nancy L. Thompson.
1117 Tyrosine Phosphorylation is Kequired for Up-Regulation of the HOX-11
(ATnCthLo-n3y) DH. oHmoe,o baondx MiPnrgo toLu-.o ncogene in T Cells. Nan Zhang, Wei-fang Shen, Tumor Biology 1194 AFuntunroe uAnncnuealm eMnetetsi ngs of the AACR
1160 Protein Metabolism in Human Colon Carcinomas: Jn Vivo Investigations Workshop on Histopathobiology of Cancer
1122 An Anoxia Inducible Endonuclease and Enhanced DNA Breakage as Con- Using a Modified Tracer Technique with 1-(1-!3C]Leucine. Egbert Hagmiiller, Workshop on Molecular Biology in Clinical Oncology
tributors to Genomic Instability in Cancer. Chery] A. Russo, Thomas K. Weber, Hermann B. Kolimar, Hans-Joachim Giinther, Eggert Holm, and Michael Trede. Workshop on Methods in Clinical Cancer Research
Carmine M. Volpe, Daniel L. Stoler, Nicholas J. Petrelli, Miguel Rodriguez-Bigas, AACR Special Conferences in Cancer Research
William C. Burhans, and Garth R. Anderson. 1168 Malignant Transformation of the Human Endometrium Is Associated with CRaelceenntd arD eaoft h Events
1129 cENr.xe paRrt.ei scL seimCooanin nceeo.rf .t heM .M eF.t /DHie pRaetnozcoy, teR . GProouwltsohm , FaMc.t orOl iRveercoe,p tPo.rM .i n CHomuomgalino , Paann-d OWMaivlnemgre-reS,ox upnCrdhe esrTysslai oo,J n.o M fPa atdLtiahnce,t wo fMeaFr.r rkKi onh Al.e rM,eW srJosonehann,g eAr.B riMdcRgLNeatAc h lE.a ann,Hd e aalnyPd,r otKReaeirxne .n C.D D.a BvGeirndat yl.e yK,. 1196 Erratum
Acknowledgment to Reviewers, 54: 6582-6590, 1994.
1139 Retroviral Insertional Mutagenesis as a ‘Strategy for theI dentification 1176 Preclinical Evaluation of LU 79553: A Novel Bis-naphthalimide with Potent
of Genes Associated with cis-Di Resistance. Antitumor Activity. Peter F. Bousquet, Miguel F. Brafia, Donna Conlon, Kathleen
Shi-Jiang Lu, Shan Man, Maria R. Bani, Dena Adachi, Robert G. Hawley, M. Fitzgerald, Denise Perron, Celia Cocchiaro, Renee Miller, Marina Moran,
Robert S. Kerbel, and Yaacov Ben-David. Jonathan George, Xiao-Dong Qian, Gerhard Keilhauer, and Cynthia A. Romerdahl. 1197 Author Index
March 15, Number 6
Advances in Brief Carcinogenesis 1328 Overexpression of Ribonucleotide Reductase in Transfected Human KB
Cells Increases Their Resistance to Hydroxyurea: M2 but not M1 Is Suffi-
Malignant and Nonmalignant Brain Tissues Differ in Their Messenger RNA cient to Increase Resistance to Hydroxyurea in Transfected Cells. Bing-Sen
1199 Chromosomal Mapping of Members of the cdc2 Family of Protein Kinases, Expression Patterns for ERCC/] and ERCC2. Meenakshi D. Dabholkar, Mitchel Zhou, Nan-Yung Hsu, Bi-Cheng Pan, James H. Doroshow, and Yun Yen.
cdk3, cdk6, PISSLRE, and PITALRE, and a cdk Inhibitor, p27*'P!, S. Berger, Justine A. Vionnet, Charles Egwuagu, John R. Silber, Jing Jie Yu, and
to Regions Involved in Human Cancer. Florencia Bullrich, Timothy K. Eddie Reed.
MacLachlan, Nianli Sang, Teresa Druck, Maria Luisa Veronese, Steven L. Allen, Molecular Biology and Genetics
GNAiiscoshriodglaannsmo e nCthi oroafz zit,h e AnHdurmeaw n Kopf2f,7 4!KPa!y HGeeunben er,t o Ca1r2lpo1 3 M.a nCdr ocIet,s aAnnda lyAsnitso niion 1267 GDp.ae rviSetsloononep ,m oefN niStgme olo kfiJ .n agJ oH-nrueesml,a antAe ladBn iDoDmN. oAnM ictGAordredgiuoncrgt, s Aasinsnda MyR uacUyosmsionang dv BeurWcsacutase lr sB Mioupcsoisesa.: JCoaonmn-e 1334 GGEaleionmnoasma i, ca nAdaH rynbLero isdsHi.ez sa Ktiiovifoo nj.Da ,N MAaJ iuhjaaS eTqNaeurvekanklcaaenisenne ,n, i nR iTtOovsmat eKoBasorhhaiuri,cn ogA,mn ansEer kkKbiay l lKiCaoronaimhepamarijr,u a,tI nikEveirejia
Leukemias. Jennifer A. Pietenpol, Stefan K. Bohlander, Yuko Sato, Nickolas Hyytinen, Sakari Knuutila, and Olli-P. Kallioniemi.
Papadopoulos, Bo Liu, Cynthia Friedman, Barbara J. Trask, James M. Roberts, 1271 Cancer Induction by an Organic Arsenic Compound, Dimethylarsinic Acid
1211 ptKi2eon7nnKsei tpihnl ,HW .uC mhKarinnoz mleoTrsu,o momJraansle.t MDM.a. p RpVoeiwrnloegny i,c tao a nP1do2 npcB1ee-r2tC— a1sV2topagf1ei3les.dt1ae ,i na.M nod ngA-bHsoenngc e Leoef, MEustthae-r (oSMghCaoeasjncaiso- .dA FykuliSkih uicsnS jhhiiiA bmcaiaYtd.aa) ,m, a Imisonato oF,3M a4t4sY/uoDis-uh iCYtrusjau sgauR, a StKhsou nziaosfh tieO,rt a nTPisr,u ettKoormiecuah tim MeaKntutsr uoddwaai,,t hGT iaFnkjiaivs ehE in CdaoMr,uc riaanin-,d 122° LMHauertukaketrei,m oinGa l eanCtde alt lh KeLo ihCnlaeht aaglReyents,ii cs tYauSnkitto e tHooo fk CiTa,mo ppatonodi tshYoevmecesir na.Ps oem AmkiIie rria.n FCuEjiMm/orCi2,, W. a GHruamydaonn
1215 LCdKaouetnnrrsnieisen,stg ht eKnHoKturr anmueaEtlexinrpa , r ePJsPoroseollisy otanSakh t,ee io nffL Deolaeudniv, se lEJpooLipaatnmch eoenMmliabtase ls, a agnCudeKel a,lt Leo aAsndsdMh oenCosatfirg oloEonmxs e prrCMyeoo,srl sdeioconSun-ulC seaa irnnd ( oC.PMr -aoCtshAteaMwt),e 1277 TCMooosldhoiinfhiyicik on gA KbaeEwrfafrmeaocntrtsi , oCfTr ayNkaputjtiu raTFlaonlcayik aO,I cncdAukuircrreaid n Hga rbayP, roJAodzhujocix tyYsma meoatnhh aartnhaee, Daenidnv eHlFio3dp4e4kmi e nRMtao rtiso..f 1347 sCFColorrale uoqdGnuie eonn CetaJ. . r cCLJoioenanstnsio . m Cao.sf ZHeanetkt le7urqso3ez1n.y,1g :o JsaiEntevyti dCei.n nc TehH oumfmopras non a ,B PrroAianmddra erRsy a nJ.gS eqP .u aTKmuleomiuonsr-S zaSCnuetlpolp, r eaasnn-dd
1221 TCSAraunonpdncprcereorews:s o s,C i.Io Smnvup oelni- ocHfaEw stacit hhoeenL n ibnF,aa osc hrL,oma ua itaTsin udomL n.o J erPr io-sftT SesruoSspni, psgtr EeedHrss wsiaeeCrhrdh.. r oRmD.aa vtSiihded r w1o. EoxKdl,ce hianTnehgromemasan s, byBPra toroLikocsiw,a aGiMnadu sdtMpuaaocgrutresson e,e assaiF nisdwb e lPble yt ears8 -CMMr.eo :ts GMhslu-oaztLxeiayrnt.pki ssoo.nr sa Eldaetwn aC rrdao nsJds. - GL5ui-nnMtkheaetbrh,ly el TaonSnigite elsM i.cI inYnde uacsPekhydo, tboFyar adMndcouincso t-sP . 1351 GRH-reJop.w ltaShcu. e mHueWanantdg i.h ofA ratph,e Rpylo6 /NCisDhKiNka2w a, GeFnraen k SBu.p pFrurensasrie,s WeHbustmearn K. GClaivoemneae , Caenldl
Concentrations of Ginsenoside Rh2 in Human Blood Lymphocytes. Jin Hua 1355 Deletion Cartography around the D13S25 Locus in B Cell Chronic Lym-
Zhu, Tatsuya Takeshita, Isao Kitagawa, and Kanehisa Morimoto Endocrinology phocytic Leukemia and Accurate Mapping of the Involved Tumor Suppres-
sor Gene. M.C. Devilder, S. Francois, C. Bosic, A. Moreau, M. P. Mellerin,
1224 Glutathione Transferase (GSTM 1)N ull Genotype, Smoking, and Prevalence Mammary and Submandibular Gland Epidermal Growth Factor Expres- D. Le Paslier, R. Bataille, and J. P. Moisan
of Colorectal Adenomas. Henry J. Lin, Nicole M. Probst-Hensch, Sue A. Ingles, sion Is Reduced by Calorie Restriction. Robert W. Engelman, Una E. Owens,
Chun-Ya Han, Bruce K. Lin, David B. Lee, Harold D. Frankl, Eric R. Lee, Matthew W. Guy Bradley, Noorbibi K. Day, and Robert A. Good.
P. Longnecker, and Robert W. Haile. Tumor Biology
1227 NlDieaoupmrhano ef ibbuJtr. oYmn.ao ttM oesiwni, s L uMTinycgph aeeC la2 n cF(e.N rFC.2h r)i YsoGtsmehainnte,a kaIA sd iSS eokFmi.ad toGi,a czadHalarlr,yv eayMn ud tI.Ja oPthasens d, D i.Sn c oMMtietn snoaB.ta dheer-, IYnecaird enFcoel loowf- uIpn teSrtnauld y CaEinnp ceTiradsi weaamnn.id oHIlunnoggeg-sYtyie d ChIinoour,g anYiuc- MeAir seHnsiuce:h , A KuSeenv-eFnu- 1358 UvS.op n-W RieHzgiiupglpmaeatlni-noL-niV noodofas u,V asGDc.iu sleBaarres iee-Eran,s dsoWot.ch iealRtiieasdal u , Garnaodnd w tShKp. o rFHaa.d citPcola rt eH.a enmda nIgtsi oRbelcaespttoormsa s.in
1232 iDne feFcitbirvoeb laRsetpsa irf roofm DaN AR adDioousbelnes-iStitvrea ndL eBurkeeamkisa anPdat iCenhtr.o mCohsriosmteop heD amBaadgiee, CLihauwn,- HSshiaunn-gF arH uHanogm,g , anMdi nCgh-iHesni- JeCnh iaCnhge,n . Yeong-Shiau Pu, Johnny Shinn-Nan Lin, AFbreerqruaenntt iEnx pEraerslsyi onB roonfc hpi5a3l orN eotphlea sEipai,d earnmda lC oGerxoprwetshs ioFna ctPorre cReedceesp tSoqru aI-s
George Iliakis, Nicolas Foray, Ghazi Alsbeih, Gabriel E. Pantellias, Ryuichi mous Cell Carcinoma Development. Valerie Rusch, David Klimstra, Irina
Okayasu, Nge Cheong, Nicola S. Russell, Adrian C. Begg, Colin F. Arlett, and Vegetable Consumption, Serum Retinol Level, and Risk of Hepatocellular Linkov, and Ethan Dmitrovsky.
Edmond P. Malaise. Carcinoma. Ming-Whei Yu, Hsiu-Hsing Hsieh, Wen-Harn Pan, Czau-Siung Yang,
and Chien-Jen Chen. 1373 Substrate Balances across Colonic Carcinomas in Humans. Eggert Holm,
DNA Strand Break Rejoining Defect in xrs-6 Is Complemented by Trans- Egbert Hagmiiller, Ulrich Staedt, Gerwin Schlickeiser, Hans-Joachim Giinther, Hans
fMeictthailo,n Cwyitdh Btuhseh , HGu.m aGonr doKnu 80St eeGle, neP.e nnGyil lAia.n JeMg.g o,Ro sasn,d JTorhenv oJr. EJ.a dMyc,M iNlaltaans.h a P. Experimental Therapeutics Leweling, Mehmet Tokus, and Hermann B. Kollmar.
1239 AJFotlatuneo nrAou.-a 5tH,ia6or-nrd iinhgoytfod nr,o tuhraean dc ilAD.na vtiiTdth uoJmm.o aTrs. PSoArptceetcrti.ov ri,t y Shoouf son5g- FlCuaoor,o uYroauccielf Mb.y Ru(sRt)u-m5,- IBDnra vaSiiidnt u GT.Cu ymJcoolhronssp.,e nJtJaeomnheyns ! JA.C. y VtiKooelslali,en ye,R iIaEndd fwuaAsrgibdoa nr iH.af ,o Orl Sdttfhuieae rltdT ,r Weaaalntbdmr eiZdnvgtie ,R oafmE r.Ei xc peMr.i mOesnhtiraol, 1379 hAMlaatneeckreaa wtait,oh nes K oIuonifdc uhcic- tmiyHocin r akEoaxfwp ar,Ae psosApikitoronas isbM uyr aiAnkn atmiHisL,e- n6sa0en d OCTelalitlgssou. od eSoAhxbieyn.ny uac leKoi-mtuirad,e s TaEinr-a
1310 Novel Antitumor Indolocarbazole Compound 6-N-Formylamino- 12,13- Biphenotypic Sarcomas with Myogenic and Neural Differentiation Express
Regular Articles rdoilhoy[3d,r4o--c 1,}c1a1r-bdaizohlyed-r5o,7x(y6-H1 3)--(dBi-onpe- gl(NuBc-o5p0y6r)a:n osInyd!u)c-t5iHo-n inodfo lTo {2,3-a]pyrras-e tShhei maEdwai,n g’Xsia nS aFr. cLoimu,a JeErWiaSn/ FF.L IL/i m, FuGisliloens TGheonmea.s , Poaunld HT.i mBo. thSoyr eJn.s eTnr,i chHei royuki
I-mediated DNA Cleavage and Mechanisms of Cell Line-selective Cytotox-
icity. Tomoko Yoshinari, Mami Matsumoto, Hiroharu Arakawa, Hiromasa Okada,
Biochemistry and Biophysics Kazuo Noguchi, Hiroyuki Suda, Akira Okura, and Susumu Nishimura. 1393 Announcements
1242 GIALMBnpaire lontoldpawoVetbnitno,tohb rsl ooiiF iscrm A aa,rnnI Crkdn eh RdsaoTutincr cnhag eegeadlaVsln ni edovb s oPy, Do Cis>Saatae4nn mdrp oR u naJmdOdNa,c ius cacoDtunlEei relpola Arner.in. a v tKa RMoUtoauEmittgaaohcncnerhenh e tbr oeMi.f rcaP g hhP,maC Rso1aeeo2ns d do, onC Rfea elnAlutlcsvhae een n Is MAC .eNSe ltoaeltAis l nfu.iCP reyrreceiml,c eee.nDd oteudsLg iloabrosayf 11331216 cNIHK1oniao,j rrvi1oberVh1ialia,-z t rdrouHoil i IhernA-yaodr5dnyao,rudkl7k oaio(xwi 6cyanHaS-, ru 1Vd)b3iTa-a-v,dozo( imo oBAoln-kCkeeipy o r-t a(og NtlCIOBoguok-xucuc5imohrc0pipai6,,yot) ry:uM aa annnsodIdoatf sss S hyauiP!n6 os) -tu-MepNmo5nru-Htoi F- toniaNA,rnin gsdmthToy iiollmtmouayuo[rmmak2ioe.,orn 3 o- Y-aAno1c|st2pheii,yvnr1i aItr3rmiio-em,lds uo in-Khiao[nytt3 sdo,Muri4xhoci-ies-cn.a] - WFWWCARuaeoooAtlcrrruCeekkkrnnRssestd hhh aooorASDp ppnpe neaoucftoooai hnnnal E l v HMMeMioenCeslttoeteshntoc ofipuedanlrstgae hsrno icbneoB isfiCo loltilohinogneigy cyC aA alAo nifcCnC eRaCCrna l cniencRireec rsa elRa ersOcenha croclho gy
1255 Changes in Topoisomerase I Levels and Localization during Myeloid Mat- Containing Pokeweed Antiviral Protein. Peter M. , DorotheaE
uration in Vitro and in Vivo. Scott H. Kaufmann, Martin Charron, Philip J. Burke, Meyers, Diane E. Hasz, Kristin Covalcuic, Daniel Saltzman, Chand Khanna, and
and Judith E. Karp. Fatih M. Uckun. 1396 Author index
April 1, Number 7
Advances in Brief 1413 Transforming Growth Factor B-induced Activation of Cyclin E-cdk2 Kinase 1428 Occurrence of Microsatellite Instability in Gastric Carcinoma Is Associated
and Down-Regulation of p27 P! in C3H 10T%2 Mouse Fibroblasts. Michael with Enhanced Expression of erbB-2 Oncoprotein. Jaw-Town Lin, Ming-
1397 Characterization of a Messenger RNA Polynucleotide Vaccine Vector. J. Ravitz, Shaochun Yan, Keith D. Herr, and Charles E. Wenner. Shiang Wu, Chia-Tung Shun, Wei-Jei Lee, Jin-Chuan Sheu, and Teh-Hong Wang.
Robert M. Conry, Albert F. LoBuglio, Marci Wright, Lucretia Sumerel, M. Joyce
Pike, Feng Johanning, Ren Benjamin, Dan Lu, and David T. Curiel. 1431 A Mutant p21 Cyclin-dependent Kinase Inhibitor Isolated from a Burkitt's
1417 Immunohistochemical Quantitation of Polycyclic Aromatic Hydro- Lymphoma. Kishor Bhatia, Saijun Fan, Gordon Spangler, Michael Weintraub,
1401 Decreased Tumor Formation in 7,12-Dimethylt hracene-treated carbon-DNA Adducts in Human Lymphocytes. Grazina Motykiewicz, Ewa Patrick M. O'Connor, Jean-Gabriel Judde, and Ian Magrath.
Stromelysin-1 Transgenic Mice Is Associated with ‘Alterations in Mammary Matusecka, Ewa Grzybowska, Mieczyslaw Chorazy, Yu-Jing Zhang, Frederica P.
ELpyintnh elMi.a lM aCterlisli aAnp. optosis. Jean P. Witty, Tim Lempka, Robert J. Coffey, Jr., and Perera, and Regina M. Santella. LInevuoklevmeimaesn t anodf CLDyKmNp2h om(aps1.6 !NTaKk4eAmyiy 7O$ts1u)k i,a nHde lpen1 5M!.N *C4la8ryk,4 7A5x2el iWne lHlummanann,
Thymidylate Synthase Gene and Protein Expression Correlate and Are Elaine S. Jaffe, and Mark Raffeld.
Associated with Response to 5-Fluorouracil in Human Colorectal and Gas- 1423 Plasminogen Activator Inhibitor-2: Prognostic Relevance in 1012 Patients
tric Tumors. Patrick G. Johnston, Heinz-Josef Lenz, Cynthia G. Leichman, with Primary Breast Cancer. John A. Foekens, Frank Buessecker, Harry A. 1441 Alternatively Spliced Variants of Prostate-specific Membrane Antigen
Kathleen D. Danenberg, Carmen J. Allegra, Peter V. Danenberg, and Lawrence Peters, Ute Krainick, Wim L. J. van Putten, Maxime P. Look, Jan G.M. Klijn, and RNA: Ratio of Expression as a Potential Measurement of Progression. Sai L.
Leichman. Michael D. Kramer Su, th-Ping Huang, William R. Fair, C. Thomas Powell, and Warren D.W. Heston.
iV
CONTENTS OF VOLUME 55
Increased Prevalence of K-ras Mutations in Lung Adeno- Experimentci Therapeutics 1565 Four Cytogenetic Subgroups Can Be Identified in Endometrial Polyps. Paola
cDMaaunrticaeitln iooRmn.as . J aicNnoa bntshoceny . n E. Mgills,a Char lesV /LC.D FKiNs2h,m anp,1 5W!i lNl4ia8m Ny.q 7R5o2m,, aNnedil pD1u8b inG,e naensd MARolobkleyerlctau tlTea.d r S trNPeuehcpaleerr,om saiRcdoobeelsr,ot g yJA .l Ckooytflt aertH,ie opMnsi uclhSafietaelm, , E a. nNCdoS lCvSi int,3e 2J9oo6hf8n 0 D1H:Nil Ato nI,d Cernatonidsf siO-c.La itMniikocnih nageo.lf DMDaaerlnc eBCleilrnog, h eAR.no dbriear,t aE nrViacnon i,V alSduessa, nnJaa n MDaerprraess,t , PhWiilmi pVpaen Mdoee rVmeann,, anPda trHiecrkm aKno oVlasn,
in Primary and Metastatic Lung Cancer.A ikou Okamoto, S. Perwez Hussain, Colvin.
Koichi Hagiwara, Elisa A. Spiliee.1M arek R. Rusin, Douglas J. Demetrick, Manuel
Serrano, Gregory J. Hannon, Masayuki Shiseki, Maimoona Zariwala, Yue Xiong, Linomide Inhibits Angiogenesis, Growth, Metastasis, and Macrophage In-
David H. Beach, Jun Yokota, and Curtis C. Harris. filtration within Rat Prostatic Cancers. Jasminka Vukanovic and John T. Isaacs. Tumor Biology
Perspectives in Cancer Research CaEhfnafdre lcetNssu cEolrfel oiTschihydmema ni,d Tyrlaanandts epD oarvStiyden rt hWa.Es xeHp erdeIlsneshyii.bo int.i onJ osoine PTrheysmsaicdcio,n e BiKsiernkaas e MiAtcrtoivvsiktiy, iCRnan yka inLt oSwho aGpirgraoa.de ned nHFulemoawn t CyGitloimocemtar. y StDeNphAe n AnWa.l yCsoiosn s,o fP eRteegri oC.n aJlo hHnestone,r ogaennde Jiotayn
TArleaxnasnfdorromwi nagn d GHraroowltdh L. FMaocsteosr. £ and Cell Cycle Regulation. Mark G. TDiofpfoeirseonmceesr aisne InIhIi Ibnihtiiboint oorfs CMherrobmaorsoonmee anSedp aVrMa-t2i6o.n aMenid CGh2e nA rarneds tW iblyli aDmN AT.
Beck. Macrophage Colony-stimulating Factor Mediates Invasion of Ovarian Can-
cer Cells through Urokinase. Setsuko K. Chambers, Yixun Wang, Robert E.
Regular Articles Cytotoxicity, Metabolism, and Mechanisms of Action of 2',2’-Di- Gertz, and Barry M. Kacinski.
fluorodeoxyguanosine in Chinese Hamster Ovary Cells. Varsha Gandhi, Shin
Mineishi, Peng Huang, Amy J. Chapman, Yandan Yang, Feng Chen, Billie Nowak,
Biochemistry and Biophysics Sherri Chubb, Larry W. Hertel, and William Plunkett.
PwPuiertniihof iCcTaa.tc iThooendx oiraao-nvid, n dCSuhucsaiarnnag c tAe.T ruiBmzecaoktr,is o nSy irnao fhM iaHc .e L iKphaiandnd,- moHabnuidml aiMnziiscn.hga elTF rauJcd.it ToirsM d.a AlseM.sc oDceivaittetd, Induction of Human BreaIstm mCuannceor-lspoecgiyfi c Antibody Responses in Cyno- AgaMeni tdyH aumKCmeiolktaluon o, SOpEKneraocyyzttaohrk ruiYo.ma c:my atjeiI-,dd eenYrtaiisfvuiehcdia tkioGo rno Mawsatsuh h-oCp,ar toaMmlaaosstaeir.un gA HkaFiyahacistkhooi r, TwHaiikdteehut cohasi h,Wi idTHeao ymaTosahmrii-,
molgus Monkeys by a Murine Monoclonal Anti-Idiotype Antibody. Mala
Carcinogenesis Chakraborty, Sonjoy Mukerjee, Kenneth A. Foon, Heinz Kéhler, Roberto L. Ceriani,
CASinhmteiim, -oiEpndrifetlhva emZnmatanitgoo, nr yG aroyAf geKCneotlll.oo fnfC ,h iCnVatehrracnlioannp oaglSeltyne eelseVi,. s aRnadbo y, BaASnbudrlaiarnhud aamSc ., RRieavd ednyNs.oo nns,t eBraoribdaarla and MalayaM oBhlatetacchualryaa-rCh atBteirojele.o gy and Genetics JlPieMfaLenr,-aF triNaonung.co liesaB erFn loeBijtoo du,i TeesDrr oimsAi,r nei qVGuéeerno enHriéqanulie n ,T aBraanglded tinsA, n nfeoS ry lDvIeijneef alna.Dm umbaotisi,o n Calanudd eC elDle gPortto,-
Response of Colon Cancer Cell Lines to the Introduction of APC, a Colon-
Clinical Investigations specific Tumor Suppressor Gene. Joanna Groden, Geoff Joslyn, Wade Samowitz,
Gneegnaettiivce anCda ncEenrz ymPaattiiecn tsE.v idSehninc e Yfaozra waL,e wisS hoEknoz yNmies hihEaxrpar, essHiioronk o in IwLaeswaiksi-, DRaobveirdt soJno,n esS,e an NiEtgaia n, BhMaatrtka chMaeruytyha,, anLdi saR ayS piWrhiiot,e . Andrew Thliveris, Margaret AFuntunreo uAnncnuealm eMnetetsi ngs of the AACR
Takayuki Asao, Yukio Nagamach?, Khushi L. Matta, and Hisashi Narimatsu. 1,25-Dihydroxyvitamin Dz Enhances the Expression of Transforming Workshop on Histopathobiology of Cancer
Growth Factor B1 and Its Latent Form Binding Protein in Cultured Breast Workshop on Molecular Biology in Clinical Oncology
Endocrinology Carcinoma Cells. Katri Koli and Jorma Keski-Oja. Workshop on Methods in Clinical Cancer Research
TtEraxomppirioen s sKibooyin z uBmalina,dd deKSoreu circCehtaii rocnMi onroiofsm uaet ,h e iNnB o zVSoiumvbouu naiYntad m aonfia n kHauV,im traoRn.a tnRCay huoiLrcaihloiwrannoii c, NiGMsoahnsiaamhudiroar-,o IKenlsftta,b iJleiatny -Joafc qMuiecsr osMaatretiinl,i teJsan iVne rHluoomya,n anGdl iPoamtraisc.k JE.m Wai llDeammss., Erik J. Z. Van de CARaeAlcCeeRnn td arSD peeaocfti haEslv enCtosn ferences in Cancer Research
Yoshimura, Toshitaro Nakagawa, Kouzui Shii, Kazuo Hasegawa, and Shigeaki Characterization of hprt Splicing Mutations Induced by the Ultimate Car-
Baba. cinogenic Metabolite of Benzo|a|pyrene in Chinese Hamster V-79 Cells. Ewa
E. Hennig, Allan H. Conney, and S-J. Caroline Wei. Erratum
Epidemiology T. L. Chen et al., 55: 810-816, 1995.
Inhibition of Proliferation by L-myc Antisense DNA for the Translational
Racial Disparity in the Association of p53 Gene Alterations with Breast Initiation Site in Human Small Cell Lung Cancer. Hirotoshi Dosaka-Akita,
Cancer Survival. Yih-Homg Shiao, Vivien W. Chen, W. Douglas Scheer, Xiao Kenji Akie, Hiromitsu Hiroumi, Ichiro Kinoshita, Yoshikazu Kawakami, and Akira
Cheng Wu, and Pelayo Correa. Murakami.
April 15, Number 8
Advances in Brief Regular Articles Immunology
Minimal Determinant Expressed by a Recombinant Vaccinia Virus Elicits
Expression of the Prostate-specific Antigen Gene by a Primary Ovarian Therapeutic Antitumor Cytolytic T Lymphocyte Responses. Barbra Jill
Carcinoma. He Yu, Eleftherios P. Diamandis, Michael Levesque, SylviaL . Asa, Biochemistry and Biophysics McCabe, Kari R. Irvine, Michael I. Nishimura, James C. Yang, Paul J. Spiess,
Maria Monne, and Carlo M. Croce. Effect of Estrogen Withdrawal on Energy-ric’. Phosphates and Prediction of Eliza P. Shulman, Steven A. Rosenberg, and Nicholas P. Restifo.
AnKsensya opceiEkap,it tiMhoeanln iuaoelfl RCaSeetlr lrp an1oL5,i! nNeDs*a v4iBbdju tpB 1e6anc!ohtN, K 4PD raviDimedal reTytr ioonnRose, nawalint dh TCuMhemoronyr!os s.Lo .m yWDaa lw5kne r i.n FrKaisde-r EtQEu.rsi otsGsrt.co oorgKfperfyni. s tojDfae nFpsoeenun,rd eNHnilcuse m BarnMiio nnnBierrt,eo arsRetod b eCrabtn yc Cielnar r kVeXi,ve on Moog3rg Iaepfnt sMs a.S gpnCaelntaguis-c T hARo. emssKreoinns,at enncasene dn, S BpjPeoacru-ln AaMnsedsl oacTniooamtmoiamo.in c hTibo esthOiwnreooe. n K agSeisahliytla , LeSwhuinsj*i HEixrapir,e sTsoirou n Kiamnudr a,T uNmoobruo PHranoagi,r eSsos Oihotina,n
Frequent Loss of Heterozygosity at the Retinoblastoma Susceptibility Gene Quantitation of 6-Thioguanine Residues in Peripheral Blood Leukocyte Molecular Biology and Genetics
(RB) Locus in Aggressive Pituitary Tumors: Evidence for a Chromosome 13 DNA Obtained from Patients Receiving 6-Mercaptopurine-based Mainte- Detection and Cloning of a Common Region of Loss of Heterozygosity at
Tumor Suppressor Gene Other Than RB. Lin Pei, Shlomo Melmed, Bernard nance Therapy. David J. Warren, Anders Andersen, and Lars Slordal. Chromosome Ip in Breast Cancer. Hirokazu Nagai, Massimo Negrini, Stephen L.
Scheithauer, Kalman Kovacs, William F. Benedict, and Diane Prager. Carter, Diane R. Gillum, Anne L. Rosenberg, Gordon F. Schwartz, and Carlo M.
Expression of Siaa2—6GalB1—4GIcNAc Residues on Sugar Chains of Gly- Croce.
ASa toNsohvie l KoCkaurnac,e r KeTnhzeor aTpaiyn akBaa,s eYdu jio n NaOitxoy,g eannd RMaodtiochaalrsu. TKoosnhdoi.k azu Yoshikawa, ccMoauprrarctoiatn,eo imnMasa: s aIKhnAaictpdlspeuul kdioicK naugrtYo iakoCimn,aas sr hacinoitdfna ,oTY eurmjiKbice rhiMyokasoota nsniuFtcouh kkeaus.As nhjtiaimpgaoe,nn iscT aoi snh iAHog gulmSuaatkniin yianCm oal,Io nfF oursA adEyeaonrsolh-iy DiA.nr gu WgrG irgRohewts.ti hst aFnaccet oarn d ByG enGee neA mpElxipfriecsastiioonn. PAoitpeinntgi alH uaRnegg,u laHtoendg nabny TJrina,n safndo rJmi-m
Prevalence of Androgen Receptor Gene Mutations in Latent Prostatic Car- Defective G2 Checkpoint Function in Cells from Individuals with Familial
cC.i nAolmlassbr oofkr,o m Jr.J, aHpiarnoeshsie NMisehni.i, HSihrino yuWkaik uiTa,k aJh.a sChairl, BMaarrseatktu, nia ndF uJreufsfa tBoo,y dW.i lliam Carcinogenesis CCyanntcheira LS. yInndnreso,m eNse.l sonR icRhhaordde s,S . TPhaeual esD,. TEilsetnyi, ND.e niLseev eAd.a kGoaul,l owSaayn,d raL awJ.r eWnicles onA,.
Role of Ornithine Decarboxylase in Epidermal Tumorigenesis. Amy Clifford, Donehower, Michael A. Tainsky, and William K. Kaufmann.
AGMFLii4zLuz--so1teMtIpi Sp, e G eAFnCnrienme ain RncoehM,a-a rArriMmaaaer nrigiaTcee samtCneir,-in sBttrSsiiin latv iiinasR ahAp TcaonusCottltieat, si ,sM iCyfaLeirolclrooae tididaoM nn.a L eSCuErulkobiecate,my ,ip Aaen:sEdl ri eAaasnC sadon BaciYaionanoidtu,iin ,o gnF MrawAaringctceooh. David Morgan, EStxuaprte rH.i Ymuespna,t aAlle janTdhroe rPearaplteau Stoilecr,s a nd Susan Gilmour. TiMnih ceAh dasedclii tdi GoaFnlal oc,tt oo rYD uotouanbk al He-uOSkmtuarmnau nrdaC, h Braronedma okM siocRmheapeea li r8.R .R eKLesintesobhreire. s KoVm(aDt)sJu , ReNcoobmuboi nKau'b ota,
Mandelli, and Francesco Lo Coco. Role of Thymidine Phosphorylase Activity in the Angiogenic Effect of Effects of Tamoxifen Administration on the Expression of Xenobiotic Me-
Platelet-derived Endothelial Cell Growth Factor/Thymidine lase. tabolizing Enzymes in Rat Liver. Emile F. Nuwaysir, Yvonne P. Dragan, Colin
TTihsrsoume binFa cRtoerc-eipntiotri atoend MalTihgrnoamnbti nM elGaennoemraat iCoenll s. AcEtdigvaart eGs. Fitshchee r, SiWgonlaflrianmg WKiaezurtzabkaa KoMnisytaadnetrya,, YuTjoim oYyaumkaid a, Suamnidz aSwhai,n -icMhii saAkkoi yaHmaar.a guchi, Hiroki Yoshida, R. Jefcoate, V. Craig Jordan, and Henry C. Pitot.
Ruf, and Barbara M. Mueller. Tumor Biology
DNA Damage in Cyclophosphamide-resistant Tumor Cells: The Role of
Glutathione. Mary E. Richardson and Dietmar W. Siemann. Transformation of Thyroid Epithelium Is Associated with Loss of c-kit
Relationship of Multidrug Resistance to Rhodamine-123 Selectivity between Receptor. Pier G. Natali, Maria T. Berlingieri, Maria R. Nicotra, Alfredo Fusco,
CDSaarvruargca ijn,E ofmfalnaud x .Ta hneDdoa dnioNérolere m aJ.Bl r LoaumEtppyii-dtBihosey.lé i,a l DCeeslplisn:a TaKoxlooln iaasn,d VCihnunb laJsintgi neW u,M odNiurlaamtoel SnSacolhdirecefycilkci,ci eanAnccdyi dC lVIainurhduiisba i tRsE. x pULrlitebresrastviiiono.nl .e t- Gaaynlde ciE.s -PWloaltosicnhuamk-,i ndJuochend PHaunomzazon, ISmtmevue-n bDEilufagfseetnroiemon atsiS.aa ln tAokrEioxr,pa r AeNlsadskoia ognBai wgoaotrfta i,,P laeJniedfo ftrGreioya pnhcMiainlr blroaa nndVdte ,c cMhTiiadok.ka isnhei Miunr aAmdavtasnu,c edT hoNmeausr o-F.
Abrogation of the G2 Checkpoint Results in Differential Radiosensitization The Role of Human Glutathione S-Transferase Isoenzymes in the Formation Deuel, Huaging Zhao, Avital Cnaan, and Garrett M. Brodeur.
of Gi Checkpoint-deficient and Gy Checkpoint-competent Cells. Kenneth J. ef Glutathione Conjugates of the Alkylating Cytostatic Drug Thiotepa. Expression of Brain-derived Neurotrophic Factor and p145!TkB afr ects
Russell, Linda W. Wiens, G. William Demers, Denise A. Galloway, Sharon E. Plon, Hubert A. A. M. Dirven, Esther L. J. T. Dictus, Niek L. H. L. Broeders, Ben van Survival, Differentiation, and Invasiveness of Human Neuroblastoma Cells.
and Mark Groudine. Ommen, and Peter J. van Bladeren. Kazue Matsumeto, Randal K. Wada, Joyce M. Yamashiro, David R. Kaplan, and
Carol J. Thiele.
Differential Sensitivity of p53‘—) and p53‘*) Cells to Caffeine-induced Alterations in the Topoisomerase Ila Gene, Messenger RNA, and Subcel-
Radiosensitization and Override of G2 Delay. Simon N. Powell, Jeffrey S lular Protein Distribution as well as Reduced Expression of the DNA
DeFrank, Paul Connell, Maeve Eogan, Frederic Preffer, David Dombkowski, Wei Topoisomerase II B Enzyme in a Mitoxantrone-resistant HL-60 Human Announcements
Tang, and Stephen Friend. Leukemia Cell Line. W. Graydon Harker, D. Lynn Slade, Ryan L. Parr, Future Annual Meetings of the AACR
Pamela W. Feldhoff, Daniel M. Sullivan, and Mark H. Holguin. Workshop on Histopathobiology of Cancer
pDDluiabstari,un p tQaiinomdni n PoeZfnh taponx5,i3 f yKFulrlutin nceWt..i onSKa oihjSnue,nn sAiFltabnie,zr etsM aJr.Bt riFenoa rsnLat.c eS,Cm ainJtrhc.,,e ranD de nMnPCiaFstr -i7Jc.k RMiCv.eel tlO s’ [C1to, onD niCoairns.e- tAEidnowtnaiarl- dB CAo4Wn6.s eBnMlsoaunnkso, c laJonenrdra yl i nA .AV niPtveoit ebroasndodyn , iMna cnd3V i:t RrooHb euCrmhtaaonr aiLcz.ta eCtreiiroizanan tii. oUns.i ngJ osae pNho vRe.l CoPuotsoi,- WWAReAoocCrreRkkn ssthh ooSDpppe eactooihnnas l MMoeCltoehncofudelrsae rn icne BsiC olilinonig cyCa la nicnC earCnl cienRriec saelRa ersOcenha croclho gy
Calendar of Events
Repression of Protein Kinase C and Stimulation of Cyclic AMP Response Effectiveness of 6-Aminolevulinic Acid-induced Protoporphyrin as a Photo-
Elements by Fumonisin, a Fungal Encoded Toxin Which Is a Carcinogen. sensitizer for Photodynamic Therapy in Vivo. Zhongxue Hua, Scott L. Gibson,
Chongxi Huang, Martin Dickman, Gail Henderson, and Clinton Jones. Thomas H. Foster, and Russell Hilf. Erratum
A. J. Staal-van den Brekel et al., 54: 6430—6433, 1994.
Use of the Stress-inducible grp78/BiP Promoter in Targeting High Level Suppression of the Proliferation of Ras-transformed Cells by Fluoro-
Gene Expression in Fibrosarcoma in Vivo. Gadi Gazit, Susan E. Kane, Peter mevalonate, an Inhibitor of Mevalonate Metabolism. Jennifer A. Cuthbert and
Nichols, and Amy S. Lee. Peter E. Lipsky. 1810 Author index
Vv
CONTENTS OF VOLUME 55
May 1, Number 9
Advances in Brief Tumor-associated Sialylated Antigens Are Constitutively Expressed in Nor- 1941 Loss of P16INK4 Expression Is Frequent in High Grade Gliomas. Ryo
mal Human Colonic Mucosa. Shunichiro Ogata, Immanuel Ho, Anli Chen, Derek Nishikawa, Frank B. Furnari, Hong Lin, Wadih Arap, Mitchel S. Berger, Webster K.
Dubois, Joseph Maklansky, Anil Singhal, Sen-itiroh Hakomori, and Steven H. Cavenee, and H-J. Su Huang.
Inhibitiono fA poptosis during Development of Colorectal Cancer. Atul Bedi, Itzkowitz.
Pankaj J. Pasricha, Adil J. Akhtar, James P. Barber, Gauri C. Bedi, FrancisM .
Giardiello, BarbaraA . Zehnbauer, Stanley R. Hamilton, and RichardJ . Jones. Activation State-specific Monoclonal Antibody Detects Tyrosine Phospho-
1817 PUpa-rRaegmueltaetirio nn Meotfa stthaet ic Prostate CancerS.i alTyrl!o ndL eJwoirsg*e:ns enA, NAeaswm unPrdo gnBoesmteri,c 1875 Marked Differences in Ctaher cRoilen oofg 0e°n-Aelskyilsgu anine ii n hprt Mutagenesis in riynlga tTehdi s p1Re8cse”p¢t“o/r.r bBM-ic2h aeiln aP .S uDbisGeito voafn nHau maandn DaBvrieda stF . TSutemron.r s Overexpress-
Olav Kaalhus, Kjell J. Tveter, Havard E. Danielsen, and Magne Bryne. onate, N-(2-
Decreased Expression and Function of a-2 Macroglobuiin Receptor/Low Harry Vrieling, Corrie M. M. van Teijlingen, Georges R. Mohn, Ad D. Tates, and Tumor Biology
rDaenesdni ssiCthtaaynr tl eLsMi opuJo.ps Greoo mtTeeriu.nm orR ecCeepltlso.r -Mraerliaatne d C. PLruontae,i n Anigne laP hoFetroradryion,a mNiacta liTe heRrucakpeyr-, 1883 dAAluubcteeorcdt r iAEn.pe i vdaTne rramZenaelsl faonNdre.mo ipnlags iaG:r owPotthe ntiFaalc toIrn voal vIesm eDnits peonfs iAblltee rnfaotre vE-rpaisd"e4r4m ajnl. cGN.ee lolMvuealisarrc, ulaSanpdrh iezMr.ao tiiNdoesne: m anMI.an gdunceetdi c GRreoswotnha ncoef IMmipclraonitmeadg inCg6. GR.l ioAbmraa movMiutlcthi,-
Tumor Regression in Monoclonal Antibody-treated Patients Correlates with Growth Factor Receptor Ligands. Andrzej A. Dlugosz, Christina Cheng, Erin K.
tAMehnleni las-tPLerdeten.sa e ncHej elmo,f PeAtnetr i-RIadginohtaympem-arre,a ctJiavn-eE rikT FrLéydminp,h oHcayntse sW.i gzeJlaln, aFnadg erHbaekragn, WRiolbleiratm sJ,. CoNfafdeiyn,e JrD.,a rawnidc hSet,u artP etHe.r YJu.s pDae.m psey, Bruce Mann, Ashley R. Dunn, MMDioecntee hPorwaoentrd,o -oTnMaucromcgo ernsFe. HPoarfno sdenuL,ci t- FLroIausiu smOeev neirSe trxopnPrga,et siesMneitdcsh .a eilnS iTnTugam ionsrRkosyn ,g ,o fM ipcLh5aa3we-rlde enfcJieecf ifeernAst,.
1828 Deletion Mapping in Squamous Cell Carcinomas of the Esophagus Defines BHryepaokmse thiyn laGteinoonm icin LDiNveAr s aonfd Fowliatthei/nm etthhye! -pd5e3f icGieennte RAartes. AIsgsoorc iP.a tPeodg riwbinyt,h James H. Resau, Eric Hudson, [lan Tsarfaty, and George F. Vande Woude
a Region Containing a Tumor Suppressor Gene within a 4-Centimorgan Alexei G. Basnakian, Barbara J. Miller, Nadejda G. Lopatina, Lionel A. Poirier, and
YInotiecrhvia l!F uorfu ktahwea ,D isSetiakli LMoantsgu nAo,r m ando f YCuhsrukoem oNsaokmaemu ra9.. Koh Miura, Kohei Okita, S. Jill James. 1971 Accumulation of Genetic Abnormalities during Neoplastic Progression in
Barrett’s Esophagus. Kausilia K. Krishnadath, Hugo W. Tilanus, Mark van
1831 cCiDn4o4m a.I soChfroirsmt opEhxeprr eJ.s sNi. oRna liln Panrdi mAanriyl Ka.n dR usMtegtia.s tatic Pancreatic Adenocar- Experimental Therapeutics aBnlda nkHeenrstmeainn , vaWni mD ekCk. enJ.. Hop, Ron Teijgeman, Andries H. Mulder, Fré T. Bosman,
1902 RG-2 Glioma Growth Attenuation and Severe Brain Edema Caused By
Loss of Imprinting in Hepatoblastoma. Shirley Rainier, Craig J. Dobry, and Local Production of Interleukin-2 and Interferon-y. Juri Tjuvajev, Bernd
Andrew P. Feinberg. Gansbacher, Revathi Desai, Bradley Beattie, Michael Kaplitt, Cornelia Matei, Jason 197 a) Two Isotypes of Murine nm23/Nucleoside Diphosphate Kinase, nm23-M1
Koutcher, Eli Gilboa, and Ronald Blasberg. and nm23-M2, Are Involved in Metastatic Suppression of a Murine Mela-
183 << Alternative Splicing of MLHI Messenger RNA in Human Normal Cells. noma Line. Hideo Baba, Takeshi Urano, Kazuya Okada, Koichi Furukawa, Eiichi
Francoise Charbonnier, Cosette Martin, Michel Scotte, Louis Sibert, Viviane Nakayama, Hajime Tanaka, Katsuro Iwasaki, and Hiroshi Shiku.
Moreau, and Thierry Frebourg. immunology
1842 CiR.ne lHIamutrimiocanhn,s h iaTpn du mbJeootrhwn e CeBen.l lsLR.ia ttdHliea.at tsiumoin -iNnadguacseadw a,G 1 CPhhuaasne- YuAarnr esLit, Caanrdl pG5.3M aFkuin,c tAimoyn 1911 SGREeexyjopnerrdcgertesio somiKneol en i onD,fo e nt KTeltuarhmsem o irKGnarsera drfe t,i. n b ayRnM idic tkchHaeear ndsM w-aGiGljtuahoss r,t aSfMeH avireLsgrjtaueorn cegotgCmarop eamnWt.bai libdnieelnidst tyr éImmC,mo umPnpeotldteeerxf iHcéCiglleausnnscd y, I 1982 RMViialtplroea.rm , yYacunifdan n Ggo ErSndhhoia,n nAcBne.ds r MeialA lpsF.or patnokesli,s Laasnzdl o IGn.c rReaadsveasn yiS,e nsLiitnidvai tZy. Pteon nC,i sRpilcahtairnd Gi.n
1847 me of Tumor Cell Invasion through Matrigel by a Peptide Derived
aromm tGhoet oDho,m aNiaonh irIIo RKeagniaoyna mian ,U rYiansauryyu kTi ryHpisriansh iImnah,i biTtoisohni.h ikHoi roTsehria oK, obaanyda sDhai,n Molecular Biology and Genetics SNuurdaem iMni ceS upBperaersisnegs Ha yHpeurmcaanl ceSmqiau amaonuds OsCtaenoccelra.s ticT oshBioynuek i ReYsoonrepdtai, onP auiln
Sugino. 1917 Cloning and Characterization of TCTA, a Gene Located at the Site of a t(1;3) Williams, Candy Rhine, Brendan F. Boyce, Colin Dunstan, and Gregory R. Mundy.
Translocation. Peter D. Aplan, Bruce E. Johnson, Edward Russell, David S.
1853 Expression of the Gastrin-releasing Peptide Receptor Confers a Growth Chervinsky, and [lan R. Kirsch.
Response to Bombesin in Immortalized Human Bronchial Epithelial Cells. Dissociation of p3acde2 Complex Formation from Phosphorylation and
Ala-Eddin Al Moustafa, Ming-Sound Tsao, James F. Battey, and Jean Viallet. 1922 Allelic Loss of Sequences from the Long Arm of Chromosome 10 and Histone H1 Kinase Activity. Scott T. Eblen, Michael P. Fautsch, Rebekah J
Replication Errors in Endometrial Cancers. Stacia L. Peiffer, Thomas Burnette, Melissa Snyder, and Edward B. Leof.
J. Herzog, Doris J. Tribune, David G. Mutch, Deborah J. Gersell, and Paul J.
Perspectives in Cancer Research Goodfellow.
MInotleercvuelnatri on.I nsEilgihste s iC. nKtooh nC aanncde rL anIcnev aAs.i onLi:o ttaS.t rategies for Prevention and 1927 CEixgparreeststieo nS moofk ec -fForsa ctiino nQsu.i eTshcoemnats SMwiilslse r. 3T3 Cells Exposed to Aqueous ACFaunltlun reof ourA nnNcnoumeailmn aetMnieotentssi ngfso r oAf AtCheR AAAwCaRr ds
Regular Articles 1933 oaMMfnia dcs rtaohnResoy arotiiSe ctlhoTliemi rtaaSecas hth.oiAd mlaattG,eee r.na Kt uinToianoms u rSiaant, o hA,dK eeSnna bouSmraaoka tSaae,nk diC yhaDimihafa,fy earA ekniMthaiieakstoae wdSa u,zA udkYeia,ns ouYcsohasirh ickiSiun zouEmkdiaa,, WCWARaeooAlcrrCeekknnRsstd hh aoorSDp ppe eoacoftoin hn aE lvH MeienCsttotshon pofadetrshe onbicineo slC loiginyni cCaoalf n cCCeaarnnc ceeRrre seRaersceha rch
Biochemistry and Biophysics 1937 The CAG and GGC Microsatellites of the Androgen Receptor Gene Are in
Natural Estrogens Induce Modulation of Microtubules in Chinese Hamster Linkage Disequilibrium in Men with Prostate Cancer. Ryan A. Irvine, Mimi C.
V79 Cells in Culture. Eriko Aizu-Yokota, Akiko Susaki, and Yoshihiro Sato. Yu, Ronald K. Ross, and Gerhard A. Coetzee. 2005 Author index
May 15, Number 10
Advances in Brief Regular Articles Epidemiology
2111 Infection with Helicobacter pylori Strains Possessing cagA Is Associated with
Insulin-like Growth Factor I Overexpression in Human Pancreatic Caacer: an Increased Risk of Developing Adenocarcinoma of the Stomach. Martin J.
Evidence for Autocrine and Paracrine Roles. Uwe Bergmann, Hitoshi Biochemistry and Biophysics Blaser, Guillermo I. Perez-Perez, Harry Kleanthous, Timothy L. Cover, Richard M.
Funatomi, Munehiro Yokoyama, Hans G. Beger, and Murray Kore. 2056 Transforming Growth Factor B Isoform-specific Differences in Interactions Peek, P. H. Chyou, Grant N. Stemmermann, and Abraham Nomura.
with Type I and II Transforming Growth Factor B Receptors. Guo-Hao K.
sNiosntianntv astiove 4 -HDyedt ection of Elevated GlutathionMei cLheaevle lsP . inG aMmCeFs-ik7, CKeelfjis n ReK-. ZKhaotuh,l eeGnw eMn.d oMluylnd erL.. Sechrist, Sumudra Periyasamy, Michael G. Brattain, and Experimental Therapeutics
Millis, and O. Michael Colvin. 2116 Topoisomerase I-related Parameters and Camptothecin Activity in the Co-
Photosensitization by 3,3'-Dihexyloxacarbocyanine Iodide: Specific Disrup- Slconr eeCna.r cFirnanocmoai s CGeollld waLsisneers, fIrnosmo o tBhaee ,N aMtoinoincaal VCalaennctie,r KeIinlsat itTuotrer esA, ntaincd anYcveers
2017 Acetylation Polymorphism and Prevalence of Colorectal Adenomas. [Nicole tion of Microtubules and Inactivation of Organelle Motility. Christopher Lee, Pommier.
M. Probst-Hensch, Robert W. Haile, Sue Ann Ingles, Matthew P. Lons-hecker, Samuel S. Wu, and Lan Bo Chen
CErhiucn -RY. a LeHe,a n,a ndB ruHceen rKy. JL.i nL,i n.D avid B. Lee, Gordon T. Sakamoto, Harold D. Frankl, Carcinogenesis 2122 DSLyirnnutegh -eiPsnCi-ds3u .co er dM ParrAokpluoisfp etroMas.ti isoB no rInsie nrN ,ot thC eh Naper5ci3ees-s nsaeErg.ia ltMyiy veerD se,Hp euOnmldiaevnenr t PSroaornts otrMa,at ecY roosChmaiontlcaeetsrcu u lCSaeelril,
Metallothionein Null Cells Have Increased Sensitivity to Anticancer Drugs. 207 = Ultraviolet Radiation Induction of Squamous Cell Carcinomas in p53 Trans- Toshiyuki Toko, Jane B. Trepel, and Erasmus Schneider.
Yukihiro Kondo, Elizabeth S. Woo, Anna E. Michalska, K. H. Andy Choo, ifid John genic Mice. Gang Li, Vincent C. Ho, Ken Berean, and Victor A. Tron.
S. Lazo. 2129 Cytoplasmic Localization of a Mutant M; 160,000 Topoisomerase Ila Is
2024 NmDeeeosdhpialanatese,td i cK eDveilRnie vvJee.rr ySs ciaononif o na,n A cacnAdon mtpDia-lvriiasdsh eTdR. iCbuorbizyey lm. eH.i ghM . EFfefnigc,i enGc.y CaAbrdee fo}, viJreaslsy- 207 wn TCaRuniakdpda 1iz SaahtkPuiian,oit nch-hKwiiia nyydoY usahcmiiean sd h HMiiutgGmaij.ta an, A rNTraehosyftru omiiId s ISCseehllielksca.tw iavH,ei lryoK yuunMkieih diikNaoat mebIdat o,, bSTyha ikegtsehine obHpua5 ra3,N- aWgTaAotFmakIoi/o, 2135 iASEnfus fssaeao cnctD israP ut.g eo-Cdfr. eRCwseoiitltsiehtn. ao nittch e HALcuoismdsa noa fn dLP uutnya-gtI invCteae rnfcBeierproa nrt Cietolnel LNEiuxncpelr.e easSrsh ieolLnao gchao lfiE z.R aetLt.i ionMnoi irscSk iig Ancaailndsd
Receptor and Cellular Retinoic Acid-binding Protein in Breast Cancer Cells.
2029 IYedhe,n tiEfliicaas tiGoeno rgoefs ,a aSnids teVri ctGoern eL ingto. P-Glycoprotein. Sarah Childs, Ri tard Lin 2081 sIYinashm iabbnyie t,i( o—n) T-oEospfhi igoNa -lMlTeoatckahahytales-chNhi’i, n - nKGiaattlrsloua-ytNae- niiKnut wrtaohtseao ,g RuaatKn aizGdulihaninekd-oui lnadOruy ca,eS dt oMamCsaaacrohc .i nIoTngeaetgsanukere-o, Martin Widschwendier, Ginter Daxenbichler, Otto Dapunt, and Christian Marth.
Yoshitaka Kitao, Masami Suganuma, and Hirota Fujiki. Molecular Biology and Genetics
Adenomatous Polyposis Coli Gene Mutations in Ulcerative Coli: §-associ- 2140 Identification of a New Immunoglobulin Superfamily Protein Expressed in
ated Dysplasias and Cancers versus Sporadic Colon Neoplasms. Li } Tarmin, Induction of c-fos and c-jun Proto-oncogene Expression by Asbestos Is Blood Vessels with a Heparin-binding Consensus Sequence. Marie E. Beckner,
Jing Yin, Noam Harpaz, Marc Kozam, Jeroen Noordzij, Lilian B. Antoni {Hai-Yan Ameliorated by N-Acety!-.-Cysteine in Mesothelial Cells. Yvonne M. W. Henry C. Krutzsch, Mary L. Stracke, Sonya T. Williams, Jorge A. Gallardo, and
Jiang, Olivia Chan, Karina Cymes, and StephenJ . Meltzer. Janssen, Nicholas H. Heintz, and Brooke T. Mossman. Lance A. Liotta.
203 e pH1u6a ngG,e naen d AlKtienr-aMtaionngs Lianu .N asopharyngeal Carcinoma. Kwok-Wai L Dolly P. Clinical investigations 2150 CFhraerqaucetnetr izGaetnieotni c of ICmhbarloamnocseo me 99 qi n aHnudm aRna reO vaArlitaenr atNieoonpsl asIinav olIvdienngti fi9eps,
GFLeryenmqepu heonIctnya tcitHicov matoLizeoyun.gk eomuEislia z aDbIeelnthed teipWoe.nn sd eNoneftw cDo/omfJb 3,SDi 2s1e8Aa nsjeou n STth1ao3gmqea1 s4a, n idn A lRBee-xtCainen §b§rC lhSareslotknoiirmkca, 4PWMi-halramsgsooherne p,rh iIot MCalal irininSyait lcroa)Alld.i onxa-PaBoncerdcnu ieabdPreiihtcntaiiir,n, m aSctIt(aoanFkl oCi BEn.Pe otKgiga2cey3se 7i,6, S2 )ta.unM dda ys PJsaiioumfml oC3 a’As-.Bs rDiededVyaaa.m, si enyLo,y -n3n'D o-n(Aa2dl-admm se,tB hiosPsxeeytt-et,r 2158 ICMNnoaocterltxmuhpaderliwe n sgsPa .in odCBn oD eKNnNoetfoe2 ,p. lM auRsoltbtDieiarcpvt li deBF r. eECOa.szs totlrS soc.ghT ueilTnsths zou,e Rmsea Lcsie aspanCt .do VrHa iannmd VielaMrtrCvoieFnae,-nr t7, a ndMKC eeeAslnlnsnsdee.rtn ehgUw el rrHi K.c. h R GBNouPAdfesewtfi ofnewr.,i,n
Seung Y. Lee, and Milan Potmesil. Emanuela Fecarotta, and Giorgio Vidali.
Analysis of Topoisomerase I/DNA Complexes in Patients Administered To-
RCeatr cGiennoem a SiCleelnlc iDnigf feIrse nAtsisaotciiona.t edE lewaintohr BR.a fC-a1r-soinn,d ucMeardt inM eMduclMlaati §fh ,T Shtyerpohiedn pMoatrekc aTn.. MuDleleepr.a Subramanian, Eric Kraut, Albert Staubus, Donn C. Young, and 2166 LMoasssa yoosfh i Heltiezruokaz,y gJousni tyYa suadta , 11Rpe1i5k o inM akMianloi,g nTaentts uyGal iOonmoa,. TaYkuakimhaiskao KSaoynaomdaa,,
B. Baylin, and Barry D. Nelkin. Takashi Yoshimoto, and Takao Sekiya.
2104 Prostate-specific Antigen Is a New Favorable Prognostic Indicator for
Women with Breast Cancer. He Yu, Maurizia Giai, Eleftherios P. Diamandis, 2169 Detailed Deletion Mapping of Chromosome 6q in Borderline Epithelial
2053 No CDKN2 Mutations in Neuroblastomas. Christian P. Beltinger, Pc fr S. White, Dionyssios Katsaros, Donald J. A. Sutherland, Michael A. Levesque, Riccardo Ovarian Tumors. Kerry J. Rodabaugh, Gayle Blanchard, William R. Welch, Debra
Enk P. Sulman, John M. Maris, and Garrett M. Brodeur Roagna, Riccardo Ponzone, and Piero Sismondi. A. Bell, Ross S. Berkowitz, and Samuel C. Mok.
v1
CONTENTS OF VOLUME 55
Tumor Biology 2191 Carcinoembryonic Antigen and Other Glycoconjugates Act as Ligands for 2212 Nerve Growth Factor Stimulates Clonal Growth of Human Lung Cancer
2173 Recombinant Human Interleukin 4 Has Antiproliferative Activity on GLoatlaenc,t iPne-t3e r iTnh oHmausm,a nJ. MCilobluornn CJeasrsucpi,n oMmiano ruC elFlus.k udDaa,v iHda nWs.- JoOahcahninme siGaanb,i usD, aafnad NCeelrlv eL inGerso watnh d Faa cHtuomr anB inGdliinogb lSaistteosm aI nvCoellvli nLgi nTey rEoxspirnees siKnign asHei ghS-i gAnfafliinnigt.y
Human Tumor Cell Lines Derived from Epithelial and Nonepithelial His- Reuben Lotan. Elisabeth Oelmann, Lydia Sreter, Irmela Schuller, Hubert Serve, Michael
tologies. Max S. Topp, Christos A. Papadimitriou, Florian Eitelbach, Michael Koenigsmann, Bertram Wiedenmann, Dorothea Oberberg, Birgit Reufi, Eckhard
Koenigsmann, Elisabeth Oelmann, Birgit Koehler, Dorothea Oberberg, Birgit Thiel, and Wolfgang E. Berdel.
Reufi, Harald Stein, Eckhard Thiel, and Wolfgang E. Berdel.
dDuocwend- ReMgeullaantoimoan Coefl lIsn teCraluesueksi n Se6l eRcetcievep toRre sias tCahnacien toi n IInntteerrlleeuukkiinn 66 bTurta nnso-t Announcements
2177 S(RpNerGse2pa)odn isaneng d to«a n4dt1 he FIoSncttaeilgm ruilCnao.tn itJoaonjc it loifdFa ,o BroAmltaehtx iaonMdner laa onfMo .m HaLu-. amMsaesnioj cnei,Ma etRelodab enrotPm raCo .t eSCopegilrlloys,c aEnidn tToon iaOtntci,o stGiaotrigni o MP.a rmiAannnia, aSnidl vaMnair, ioG iPu.l iCaonlao mbFoer.r ari, Giacomo Paonessa, Carlo CFWauoltrluk rsefh oroA pnN nouomani ln HaitMsietoeontpsia ntghfosob ri ooAfl AotgChyeR AofAA wCCaaRnr cdesr
Roos, Leo T. Furcht, and James B. McCarthy. Workshop on Methods in Clinical Cancer Research
AACR Special Conferences in Cancer Research
Recent Death
Calendar of Events
Isolation and Sequence Analysis of Human Cadherin-6 Complementary
2186 Involvement of CD45 in Adhesion and Suppression of Apoptosis of Mouse DNA for the Full Coding Sequence and Its Expression in Human Carcinoma
Malignant T-Lymphoma Cells. Kenji Hanaoka, Naoya Fujita, Sang-Han Lee, Cells. Yutaka Shimoyama, Masahiro Gotoh, Takeo Terasaki, Masaki Kitajima, and
Hiroyuki Seimiya, Mikihiko Naito, and Takashi Tsuruo. Setsuo Hirohashi.
June 1, Number 11
Advances in Brief 2310 Chemoprevention of Colon Carcinogenesis by Phenylethyl-3-methylcaffeate. Mutant p53 Rescues Human Diploid Cells from Senescence without Inhib-
Chinthalapally V. Rao, — Desai, Abraham Rivenson, Barbara Simi, Shantu iting the Induction of SDI1/WAF1. Jane A. Bond, Jeremy P. Blaydes, Janet
2225 GTMirucomhwoaterlh PSoIulnlphapikr.b eitsosro.r HuAnctgi viTt.y Houfy nht,h e CaGtehnaeri naE ncLoardsisnogn, MSatemvmean ryN-adreodr,i veandd 2316 ADmNiAn , Aadndd ucBatn daFrour mSat.iR o n and T-Lymphocyte Mutation Induction in F344 RFioownsao nS,. WMylilcihee.l e F. Haughton, James R. Smith, David Wynford-Thomas, and
223 Ne Crocidolite Asbestos Fibers in Smoke from Original Kent Cigarettes. SRmaittsh , ImNpanlcayn teFd. Fuwliltehrt onT,u mRoorbiergte nHi.c HeDfoliscehs, aonfd 1F,r6e-dDeirnicikt roAp.y rBeenlea.n d Beverly A. 2410 Sveartiionne. Gregory A.l atiMoany r,in tMhiec hNaeHl2 RTeeerdm, inuPisn oWfa npg5,3 FaYcuinl itaWtaens g,T raJnoshanc ti-F.
William E. Longo, Mark W. Rigler, and John Slade. Schwedes, and Peter Tegtmeyer.
2325 Epothilones, a New Class of Microtubule-stabilizing Agents with a Taxol-
2236 Identification and Intracellular Location of MAGE-3 Gene Product. like Mechanism of Action. Daniel M. Bollag, Patricia A. McQueney, Jian Zhu,
Thomas Kocher, Elke Schultz-Thater, Fred Gudat, Christoph Schaefer, Giulia Otto Hensens, Lawrence Koupal, Jerrold Liesch, Michael Goetz, Elias Lazarides, 2418 Genomic Instability of Microsatellite Repeats in Prostate Cancer: Relation-
Casorati, Antonio Juretic, Thomas Willimann, Felix Harder, Michael Heberer, and and Catherine M. Woods. shipt o Clinicopathological Variables. Shin Egawa, Toyoaki Uchida, Kazuho
GiulioC . Spagnoli. Suyama, Chunxi Wang, Makoto Ohori, Satoshi Irie, Masatsugu Iwamura, and
Ken Koshiba.
2240 Angiogenesis-directed Implantation of Genetically Modified Endothelial Clinical Investigations
Cells in Mice. John O. Ojeifo, Reza Forough, Soonmyoung Paik, Thomas
Maciag, and James A. Zwiebel. 2334 Correlation of Therapeutic Outcome in Non-Small Cell Lung Cancer and 2422 C-erbB-2 Gene Amplification: A Molecular Marker in Recurrent Bladder
DNA Damage Assayed by Polymerase Chain Reaction in Leukocytes Dam- Tumors? Mark Underwood, John Bartlett, Jonathan Reeves, D. Stuart Gardiner,
2245 Induction of Cyclobutane Pyrimidine Dimers, Pyrimidine-(6—4)pyrimidone aged in Vitro. Fumihiro Oshita, Nobuyuki Yamamoto, Minoru Fukuda, Yuichiro Roy Scott, and Timothy Cooke.
Photoproducts, and Dewar Valence Isomers by Natural Sunlight in Normal Ohe, Tomohide Tamura, Kenji Eguchi, Tetsu Shinkai, and Nagahiro Saijo.
Human Mononuclear Cells. Peter H. Clingen, Colin F. Arlett, Len Roza,
Toshio Mori, Osamu Nikaido, and Michael H. L. Green. Experirnental Therapeutics Tumor Biology
22224593 JCXBe7h-f-aRf1rna egyye EsxFI .pr rroDeafus dniOsnaix,toy ingoG eno.nrb ayn FT ueamBn iasNcniiooocrnn,i- AainGnnotd d iEagHx,aep rneoJ rluildiPm are Men.Ast. ea nSlOtw 'aiHrnTatguzr .am ,oC erlEslr i-kda efrtS.ei rv Rehdao dSeiTsnu,gm loeK re.D oJs. SecL oituot,f 2338 SCMMehieloccehlhceotjadidynva,ie. s mE Arcicto ifv Ai.tA yc tHiuaodgnsa oinno,sf t JBaiCmsoeilsmo ind Ha.z oCaaRncescraeiurd,.o neGLsai,rd iya NPeaHwue lryn,aD nrduaengzds, CwhWiirteihs sltaPowop thenetMrJ,. . 2431 CGPSeerrlnieslsvisweb onalrtbd,i,y o nSOD teveboepfrrh aee Cxnep lMlrR. e. sDseSSyiauiottvnhke s otweIsorknf,id ,uSJ cuaelmdAfen astt bheMyod. n yT GKulomyzRolcarofowfp osr,kNo iet,ce Rriaoanlsn-pid2hs Ch(FBuCualtnctugtyso atrneL ,re iean )M.ii nc hJLaueNlliCa aPAD..
J. Antonia, Teresita Mufioz-Antonia, Gloria Soldevila, Judy Miller, and Richard
A. Flavell. Development and Characterization of Three Recombinant Single Chain Invading and Metastasizing Cardiac Hemangioendothelial Neoplasms in a
Antibody Fragments (scFvs) Directed against the CD19 Antigen. Bruce E. Cohort of the Fish Rivulus marmoratus: Unusually High Prevalence, His-
2257 Does Pregnancy Immunize against Breast Cancer? Babita Agrawal, Mark Bejcek, Duo Wang, Erica Berven, Christopher A. Pennell, Stephen C. Peiper, topathology, and Possible Etiologies. John A. Couch.
A. Reddish, Mark Krantz, and B. Michael Longenecker. Sibrand Poppema, Fatih M. Uckun, and John H. Kersey.
2262 PaInrndte evreRlonebtueirkotin n G.o6 f-H maMewdlyeieyal.to emda UpCe-lrle guAlpaotpitoons iso f bbye l-Excjt.o piMce libncdla- 2 M.E xpKr.e sSscihowna rzoer TPMahouedlre alJp. eMuoatfri tciSn p, oEnfRtfaialcpnahec oyuA .s o fR eMiase fteDalosdxt, aotraiuncdb icBHiarunb maarIanm mMu.Mn eoMlcuaeolnnlojemru.ag .a teG owisna laa PrPe.c lSiinviacaml, 2448 aMESinaxndplg rieKerg,esn vsaiiAnnout nd Jr.e BiyCrn ue laRlBseartnse. ma usEstps ientS,ht erloHimeualm:e ne SEevSli.e dcSetmnsi ctehf ,o rf MoarI rnesP ualrEi.an c-Lrliiipknpee m anGF,ur nocwHtetinhor ny. FTaC.ch trLoiysrnt cihaIn,l
Molecular Analysis of the Cyclin-dependent Kinase Inhibitor Gene p27/Kip!
iMYBnioa lsrltheHrirah,um im,rD aoo narn oHdta thtMyHaa .,l PiPahgJrienklaa,ln ni pcK iSoKeniossmet.pfa sfnlotenNir,on. r ihSSi.h kaorS poinr iKna,Ww ialTmcsazuytynaos,sk hii, RoNbYaeokruatnmaag k iM,Yo iruolSs eeitLstehieo,, TCCalakareluu sc hWiR,.. 2357 ICwVnioi tsvhaeV nkidta,rMno oa nnPaoedtnaced lr o MnDI.a.n lS VVeirnvutAoednr ht,u iAlcbaato,ni ddv yiJ tPoihheiBnsl- i pL oEaf.Mc .t Eaa mWmDsaawolilsxlaoeecr eru.,b CiocJniojhnun g aPtFer.s o.dM raucHgMaa ksaitnne rC,oP .m bWSeivsnelanetsysi oonnL, . 2455 TfEDehixcapetnr eeedP s rsLeM.is uoeErnng icgneeoe nfs o pfReC eerPlgcrleoo rsm,tLb aiitnaneen.-ad sn ptJJeeo cfaifnfHr ieucyFm . aSAKcnnahtr iiro,gPm er.nJo u-sdrtieatltha e-tAse.pd e cKGainfetinocer s, AniPantt irPgirceiinam atHineo rsa a na TnrdHa anntsdh-,e
2270 The Neurofibromatosis Type 2 Gene Product, Schwannomin, Suppresses Efficient Gene Transfer with Adeno-associated Virus-based Plasmids Com-
Growth of NIH 3T3 Cells. Mohini Lutchman and Guy A. Rouleau. plexed to Cationic Liposomes for Gene Therapy of Human Prostate Cancer. 2463 The Insulin-like Growth Factor I Receptor Protects Tumor Cells from
2275 c-RAF-1 Serine/Threonine Kinase Is Required in BCR/ABL-dependent and JMoohhaannn esP hiVliiep,w egR,a miDlaav idP hiBliopc,z kTorwasckyi ,R udKoaltlh,r yCnl aMy. SRmiotbhe,r soCna,r y DaRrorbyelr tsWo.n , Edawnadr dsEl,i AYpuotapntaowsiibso oncihna i, VivHoa.r riMs ariLa.n a RotmRaens,ni cofJfa,n KaDjasvtiudra , ARbarpahhaaeml, RubWiinb,o onPchhialiip
CNeozramrayl SzHcezymlaitko,p oiPeasliasn.i samTyo masKza nakaSkroarjs,k i, DanMiallog orPzeartraot ti,N ieGbeorraolwds kaZ-oSnk,o rsAklaa,n Gilboa. Zoltick, and Renato Baserga.
Gewirtz, Bice Perussia, and Bruno Calabretta.
Immunology 2470 Regulation of Interleukin-8 Expression in Human Melanoma Cells by the
2279 DnEexegpmaretetishvsyeil oanBt.ri eoanAs ntn eo fC aT.tn hceFe err EgussCtoernlo,lg se RneC naanR eGc.Re epLatacoptirid vuasG,te en Set Eepshtienrn o gEeBs.nt rBoaRgyeleicnne ,p tRaoenrcd epNGtaeonnrce-y 2373 PAPh-o1t odbyunta minoct ThNeFr-axpBy IDnNdAuc esB iEnxdpirnegs. siGoenr oolfd InKtiecrkl,e ukGienr al6d byM eAscsteirv,a tiAolnw ionf COorrgaazno n ED.n vBiurcoannmae, nta.n d MIsoaridaeh chJa. iF idleGru.t man, Rakesh K. Singh, Keping Xie,
E. Davidson. Goetz, Gerd Plewig, and Peter Kind.
2476 The Laminin a1 Chain lle-Lys-Val-Ala-Val (IKVAV)-con Peptide
Promotes Liver Colonization by H Colon Cancer Cells. Robert S.
Regular Articles Molecular Biology and Genetics Bresalier, Bertha Schwartz, Young S. Kim, Quan-Yang Duh, Hynda K. Kleinman,
Induction of Transforming Growth Factor 61 and Its Receptors during and Paul M. Sullam.
all-trans-Retinoic Acid (RA) Treatment of RA-responsive Human Neuro-
Biochemistry and Biophysics blastoma Cell Lines. Pamela S. Cohen, John J. Letterio, Carlo Gaetano, Jane
tSoe nSeuspcpernte ssH ubmcia2n IsF iIbnrvoobllvaesd.t s ERuegseinsita PWraongg.r ammed Cell Death, ana Failure CRhealna,t ioKnaszhuiep sM abtestuwmeoetno , GM icAhrareels t B.a nSdp orSnt,a bialnidt y Caorfo lt heJ. pT5hi3e lae.n d p21CiP!/Wafl 2481 ACFaunltlun reof ourA nnNcnoumeailmn aetMnieotentssi ngfso r oAf AtCheR AAAwCaRr ds
aDinedt aMrays sF.a t,J eFnniibfeerr, Sa.n dP icCkaerricnig,n ogJoeann neA ltRe.r LFuepctaoln , Dainadc ylRgolbeyrcte roSl. CChaopmkpions.i tion OSPa'rioCjtouennin nosFr a.n ,f olKlioshwoirn g Bhyat-iIar,r adKiuratt ioWn. oKfo hnH,u mAalbne rt LJy. mFporhnoacmea, JrC.e,l lasn.d IPnastoroi ck BaMe., WWAoAoCrrRkk sshhooSppp ecooinn a lH MieCstothonpofadetrshe onbicineo slC loiginyni cCaolaf n cCCeaarnnc ceeRrre seRaersceha rch
DNA Topoisomerase Il Is the Molecular Target of Bisdioxopiperazine Calendar of Events
Derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae. Ryoji 2394 Consistent Chromosome Abnormalities in Adenocarcinoma of the Pancreas.
Ishida, Michiko Hamatake, Robin Ann Wasserman, John L. Nitiss, James C. Constance A. Griffin, Ralph H. Hruban, Laura A. Morsberger, Tara Ellingham,
Wang, and Toshiwo Andoh. CPhatarrilceisa JP.. YLeoon.g , Elizabeth M. Jaffee, Karen M. Hauda, Stefan K. Bohlander, and 2484 EN.r rTaatkaa da et al., 54: 2895-2899, 1994.
Carcinogenesis Ring 22 Chromosomes in Dermatofibrosarcoma Protuberans Are Low- G. M. Maelandsmo et a/., Proc. Am. Assoc. Cancer Res., 36: 77, 1995.
2304 DNA Mismatch Binding Defects, DNA Damage Tolerance, and Mutator Level Amplifiers of Chromosome 17 and 22 Sequences. Florence Pedeutour,
Phenotypes in Human Colorectal Carcinoma Cell Lines. Pauline Branch, Marie-Pierre Simon, Fabiola Minoletti, Gabriella Sozzi, Marco A. Pierotti,
Richard Hampson, and Peter Karran. Frederick Hecht, and Claude Turc-Care 2485 Author index
June 15, Number 12
Advances in Brief 2497 Molecular Characterization of 12q14-15 Rearrangements in Three Pulmo- Overexpression of Bcl-x Sensitizes MCF-7 Cells to Chemotherapy-induced
nary Chondroid Hamartomas. Bernd Kazmierczak, Sylke Wanschura, Jens Apoptosis. Venil N. Sumantran, Mark W. Ealovega, Gabriel Nufiez, Michael
Rosigkeit, Kerstin Meyer-Bolte, Klaus Uschinsky, Rolf Haupt, Eric F. P. M. F. Clarke, and Max S. Wicha.
Effects of Estrogen on Apoptotic Pathways in Human Breast Cancer Cell Schoenmakers, Sabine Bartnitzke, Wim J. M. Van de Ven, and Jom
Line MCF-7. Thomas T. Y. Wang and James M. Phang. Bullerdiek. Allele-specific Mutations Involved in the Pathogenesis of Endemic Gall’ lad-
2490 Expression of Manganese Superoxide Dismutase Reduces Tumor Control der Carcinoma in Chile. Ignacio |. Wistuba, Kenji Sugio, Jaclyn Hung,
Radiation Dose: Gene-Radiotherapy. Muneyasu Urano, Masahiro Kuroda, p21C!P! |, Not Required for the Early G2 Checkpoint Response to Ionizing Yosuke Kishimoto, Arvind K. Virmani, Ivan Roa, Jorge Albores-Saavedra,
Regina Reynolds, Terry D. Oberley, and Daret K. St. Clair. Radiation. Eleni N. Levedakou, William K. Kaufmann, David A. Alcorta, and Adi F. Gazdar.
} Denise A. Galloway, and Richard S. Paules.
}t}; 2494 Ana nDte fiMneelda noRemgai.o n Roufd oLlofs s A.o f HHeertbsetr,o zyAgmoys itLya rsaot n,1 1qJi2i3r geinn CWeuitsasn,e oWuesb stMearl igK-. 2 Mutational Effects on the pi6INK4a Tumor Suppressor Protein. Rong Sjelueocrteinv e DeCnegll, CMualrttuhrae oR.f PSrtiammpafreyr , BrFeraesdte riCc arcM.i noWmaal.d manS,ha naazn d H.H eDlaeinrek eeS,.
Cavenee, Garret M. Hampton, and Karen C. Arden. Yang, Adrian F. Gombart, Manuel Serrano, and H. Phillip Koeffler. Smith.
vil
CONTENTS OF VOLUME 55
2520 Fate of Melanoma Cells Entering the Microcirculation: O\pPr 80% Survive Prolactin Synthesis and Secretion by Human Breast Cancer Cells. Erika Sequential Loss of Heterozygosity at Microsatellite Motifs in Preinvasive
and Extravasate. Sahadia Koop, lan C. MacDonald, Keit} Luzzi, Eric E. Ginsburg and Barbara K. Vonderhaar. and Invasive Head and Neck Squamous Carcinoma. Adel K. El-Naggar,
Schmidt, Vincent L. Morris, Marsha Grattan, Rama kfhokha, Ann F. Kenneth Hurr, John G. Batsakis, Mario A. Luna, Helmuth Goepfert, and Vicki
Chambers, and Alan C. Groom. 2596 Modulation of Transforming Growth Factor B1 Effects on Prostate Cancer Huff.
Ceil Proliferation by Growth Factors and Extracellular Matrix. Diane M.
2524 tCAHYhioyketste ohomsipkihkXiii . n eGIW-ekapenkdreiao ,sd auokcHfai i,dnH egut omNsahMoinra i myuYmTkaa-im Lrayzyma KkpaihsC,aoai t,rr cHoiiprnKioouycmnu iaktsiVa diarSi uhns i kTSirThsayihnpmisomegat e,on 1hi.n} Kp j,a[ zaRtuaontasoshnri id CYaKTariamkrkuayacdishanhi,gi, Morton and EveElyxnp eR.r iBamrreacnkt. al Therapeutics TGTL.aou ssmksMoi .rn eosnHf , a mIHpsGe t.t oAensrAs,.o o zcyEAigv.aao tnseMsid,at nyn Fwe.i rftAomh.ra aWP,Cro hiogrrGho. t m,SB oulsrIa.von icNmvoeea,wl s Mh.1aa1f m t,Aeilr n a vaManPeidrtk iakWsmo.ta,a rsyKiH .s. . C HKaiuvvmeRin.ane ineeW .mi in,Bq rveiPas.st ,tJ .
2603 Antimeianoma Effect of 4-S-Cysteaminylcatechol, an Activated Form of
2528 Protein B61 as a New Growth Factor: Expression of B61 and Up-Regulation 4-S-Cysteaminylphenol. Shigeki Inoue, Katsutoshi Hasegawa, Shosuke Ito, 2665 Mutations of the K-ras and p53 Genes in Gastric Adenocarcinomas from a
of Its Receptor Epithelial Cell Kinase during Melanoma Progression. Hiroyuki Ozeki, Francisco Solano, Celia Jiménez-Cervantes, Kazumasa High-Incidence Region around Florence, Italy. Tadashi Hongyo, Gregory
David J. Easty, Brenda A. Guthrie, Kavita Maung, Christine J. Farr, Richard Wakamatsu, and Keisuke Fujita S. Buzard, Domenico Palli, Christopher M. Weghorst, Andrea Amorosi,
A. Lindberg, Robert J. Toso, Meenhard Herlyn, and Dorothy C. Bennett. Monica Galli, Neil E. Caporaso, Joseph F. Fraumeni, Jr., and Jerry M. Rice.
Retrovirus-mediated Expression of a DNA Repair Protein in Bone Marrow
2533 Telomerase Activity Associated with Acquisition of Malignancy in Human Protects Hematopoietic Cells from Nitrosourea-induced Toxicity in Vitro
Colorectal Cancer. Corinne Chadeneau, Kazy Hay, Hal W. Hirte, Steven and in Vivo. Thomas Moritz, William Mackay, Brian J. Glassner, David A. Tumor Biology
Gallinger, and Silvia Bacchetti. Williams, and Leona Samson.
2673 Identification of a Monoclonal Antibody, TV-1, Directed against the Base-
2537 ZCDeihlfalfnseg r,e anntZidha ilg CiaaEnrxgcp irnZeoosusm,ia osnN i cIooslf a iRE elgaMfuailansa st,ei nd aHnadut mRatuhnteh TNSroaagrnemrsa.c lr ipMtiaomnamla ryLe velE.p itheMliinagl 2615 iK1,no1gh5ai-,bB iitsY(i oonn ag Hte,h eT Gorm)oo-w4mt,i8h, 12S-ohtf i mVoagroiroi,u s HHisuamo anEk iamnodtK oa,zM uoeuKi esiek Iog aTruaKsmahsoih,ri waKCgueinl,li sh iakbnody mMEpeasncttre ionmM,o elmLeebcsrulialeen seA . tooKf h TaTwuulmmio,or rsJ asVaoefnst seerLl .s ,C Hoonarjnnudi gckaI,tt si oaUnns de wCitltoi hv Ee nIhnRat.e nrTclaeey ulkotrih.ne D2e. livAelrayn oL.f
Akira Shirahata.
Regular Articles 2620 Uptake, Localization, and Photodynamic Effect of meso-Tetra(hydroxy- 268 GMausctirni c GeEnpeit hEexlipurme.s sionS amiune lN orBm. alH,o , PrLeanueroiep lasL.t icS,h ekaenlsd, NeNoeipll asWt.i c ToHruibmaaran,
phenyl)porphine and Its Corresponding Chiorin in Normal and Tumor Young S. Kim, Carolyn Lyftogt, David L. Cherwitz, and Gloria A. Niehans.
Tissues of Mice Bearing Mammary Carcinoma. Qian Peng, Johan Moan,
Biochemistry and Biophysics Li-Wei Ma, and Jahn M. Nesland. Expression of Peripheral-Type Benzodiazepine Receptor and Diaze
254 N An Alternatively Spliced Form of NQO, (DT-Diaphorase) Messenger RNA Binding Inhibitor in Human Astrocytomas: Relationship to Cell Prolifera-
Lacking the Putative Quinone Substrate Binding Site Is Present in Human Eradication of Large Human B Cell Tumors in Nude Mice with Unconju- tion. Helena Miettinen, Juha Kononen, Hannu Haapasalo, Pauli Helén, Pauli
Normal and Tumor Tissues. Pamela Y. Gasdaska, Hugh Fisher, and Garth gated CD20 Monoclonal Antibodies and Interleukin 2. Erik Hooijberg, Sallinen, Tero Harjuntausta, Heikki Helin, and Hannu Alho.
Powis. Johan J. Sein, Paul C. M. van den Berk, Augustinus A. M. Hart, Martin A.
van der Valk, W. Martin Kast, Cornelis J. M. Melief, and Annemarie
AFcrtiidvmaatni,o nM aorft aP rToogtehl,a tDiannaiseel PBef (iaM, MPan-d9 )S habhyr iaGre laMtoibnaasshee ry.A (MMP-2). Rafael Hekman. 2696 GSHulerunvtniaiveta hli.oM n.e TJSh. -eoTR roaelnPos.f fse,Jr. asSMeuj ladm7e ri,Gn a nCoeHlseohirn, e ctGWae.lr r iTtV uermGsorpirafsgfe ito,Ies n ,P Croeradnniedcl tiisWv iel bFfe.o rrt M O.v He.r SaileMrl.,
2556 Expression of Prostaglandin G/H Synthase-1 and -2 Protein in Human Immunology Peters.
CF.o lEovna nsC,a nJcoesre.p h SAt.a cMiaa ncLi.n i,K aragnmda nS,e rgGea rJyo thPy.. O'Neill, Philip J. Vickers, Jilly MIimcmeu notloo gEi7c alP rotReeisnp onCsoersre laint e Huwmitahn thPea piPlrleosmeancvei ruosf S1k6i nE 6/DEi7se-atsrea.n sgeI.n iHc. 2703 Expression of Platelet-derived Growth Factor B-Chain and the Platelet-
Frazer, D. M. Leippe, L. A. Dunn, A. Liem, R. W. Tindle, G. J. P. Fernando, derived Growth Factor Receptor B Subunit in Human Breast Tissue and
Carcinogenesis W. C. Phelps, and P. F. Lambert. BAlrleeans t M.C aGrocwinn.o ma. Marc D. Coltrera, Jian Wang, Peggy L. Porter, and
Multiple Genetic Alterations in Hamster Pancreatic Ductal Adenocarcino-
mas. Kuo-Wei Chang, Sergio Laconi, Kathy A. Mangold, Susan Hubchak, Molecular Biology and Genetics
and Dante G. Scarpelli. Prostate-specific Antigen Messenger RNA Is Expressed in Non-Prostate 2709 Announcements
A Mutator Phenotype Characterizes One of Two Complementation Groups Cells: Implications for Detection of Micrometastases. Mitchell R. Smith, Future Annual Meetings of the AACR
in Human Cells Tolerant to Methylation Damage. Gabriele Aquilina, Sandra Biggar, and Maha Hussain. Call for Nominations for AACR Awards
Patricia Hess, Silvia Fiumicino, Sabrina Ceccotti, and Margherita Bignami. Workshop on Methods in Clinical Cancer Research
264. v7) Suppressive Role of the Metastasis-related nm23-HI Gene in Human AACR Special Conferences in Cancer Research
2576 Bel-xj, Is Expressed in Neuroblastoma Cells and Modulates Ovarian Carcinomas: Association of High Messenger RNA Expression Calendar of Events
Chemotherapy-induced Apoptosis. Mukund G. Dole, Rama Jasty, Mark J. with Lack of Lymph Node Metastasis. Alessandra Viel, Lara
Cooper, Craig B. Thompson, Gabriel Nufiez, and Valerie P. Castle. Dail’Agnese, Vincenzo Canzonieri, Francesco Sopracordevole, Eugenia
Capozzi, Antonino Carbone, Maria Caterina Visentin, and Mauro Boiocchi. 2711 Erratum
Endocrinology 2651 Identification of an Enhancer Responsible for Tumor Marker Gene Expres- I. P. Pogribny et al., 55: 1894-1901, 1995.
An Estrogen-Independent MCF-7 Breast Cancer Cell Line Which Contains sion by Means of T nic Rats. Toshiya Suzuki, Masayoshi Imagawa,
a Novel 80-Kilodalton Estrogen Receptor-related Protein. John J. Pink, Masumi Hirabayashi, Atsushi Yuki, Koji Hisatake, Kimie Nomura, Tomoyuki
Shun-Yuan Jiang, Michael Fritsch, and V. Craig Jordan. Kitagawa, and Masami Muramatsu. 2712 Author index
July 1, Number 13
Advances in Brief Regular Articles 2831 Application of a Tumor Suppressor (C-CAM1)-expressing Recombinant
Adenovirus in Androgen-independent Human Prostate Cancer Therapy: A
2713 SLouspsp reofs sEoxrp rGeessnieo ni n ofM etlhaen opc/y6t/iCcy clLiesni-odnesp eCnodrernetl atKeisn asweit hI nIhnivbaistiovre 2S tTaugmeo rof Carcinogenesis PVraenc,l iAnnicdarle wS tCu.d y.vo nD aEvsicdh e|n.b Kalcehi,n eramnadn ,J eWr-eTis-oWnegi HZsiheahn.g , Sue-Hwa Lin, Nguyen T.
Tumor Progression. Jon A. Reed, Frank Loganzo, Jr., Christopher R. Shea,
GMroaneicmae JJ.. SWhiaellk,e rF,r anJko seG . F.H aFlluosrkeas,, JJa. neM icWh.a elF ounGtlaeinnd,e nianngd, AnJtehnnoinfye r P.K .A lBbiongod.a ny, 2769 (M4u,c5o-sfa|-qpurienofleirneen tiina lt heD NRAat ACodldouncitc FWoarlml.a tiAioinc hibryo 2K-aAjimkianwoa-, 3-Amtseutshhyi liUmmiedmaoztoo-, 2837 Effect of the Chemoprotective Agent WR-2721 on Disposition and Biotrans-
Kunimi Hatnada, Masaki Tanaka, Takemi Kinouchi, Yoshinari Ohnishi, and formations of Ormaplatin in the Fischer 344 Rat Bearing a Fibrosarcoma. D.
2719 Evidence against Dominant Negative Mechanisms of Intestinal Polyp For- Yasumasa Monden. Charles Thompson, Steven D. Wyrick, David J. Holbrook, and Stephen G. Chaney.
mation by Apc Gene Mutations. Masanobu Oshima, Hiroko Oshima, Masahiko
2723 TKHor2ba0any?sac srhIiisp, tD iioMrnaesacatllh yi rAocR teilTvasauttteisdou mnti o, oIfan ncdtr heeMa askePodr tootP or-oMol.in fcTeoargkaeettnioeo. n ca-njdu n Trbayn sAfsobremsattoiso na nodf 2774 nTMoeoinucns eenA bciaSduk min,a nTdA udmaRomer ti Bn.oP irGdol gicrkXe, s sRSietoucnaer ptt RoeHrs.su .lY tuss Npaaid,ni nDaein fdf DeaLrruewingitici haelM ,. EDGxeipu rleLisua csaiC oelnl i,o f TaRemtair- 2847 fMPlueurtnakanebtoots.ly i!s)m- adeannidn e iAnc tHiuonmsa n ofL ym2p-hCohblloarsot-o9-i(d2 -Cdeelolxs.y -2-Cfhulnuxoi roX-ief -pan-da rWaiblilnioa-m
Tracheal Epithelial Cells. Cynthia R. Timblin, Yvonne W. M. Janssen, and
Brooke T. Mossman. Clinical Investigations 2 Activity of Temozolomide in the Treatment of Central Nervous System
2727 A Variant Glucocorticoid Receptor Messenger RNA Is Expressed in Multi- 2783 GmM2-KLH Conjugate Vaccine: Increased Immunogenicity in Melanoma Tumor Xenografts. Henry S. Friedman, M. Eileen Dolan, Anthony E. Pegg,
ple Myeloma Patients. Nancy L. Krett, Shafali Pillay, Pamela A. Moalli, Philip R. Patients after Administration with Immunological Adjuvant QS-21. Fried- Susan Marcelli, Stephen Keir, Joseph J. Catino, Darell D. Bigner, and S. Clifford
Greipp, and Steven T. Rosen. helm Helling, Shengle Zhang, Ann Shang, Sucharita Adiuri, Michele Calves, Rao Schold, Jr.
Koganty, B. Michael Longenecker, Tzy-J. Yao, Herbert F. Oettgen, and Philip O.
2730 Expression of B7-1 by Highly Metastatic Mouse T Lymphomas Induces Livingston.
2734 OTRNLKapaeiaekvtjlsaeiio,nrymm i aaesMmhlraaDi ar,i,sl sNeeeaae Mantnisd uAke cr iBtTayaiolakvas kihntuidKKnys iio ,ltr liaiHenmS er oop HtIpadouhCet,i.meo elca leRn-Dly emloveu LodlisNiav,aare kt raeK srdhCTi isiao srC,sTcy uhiteinJoseeto:lro merxyamCi ascon.Wims .tp, y a.HSr aihindaAdseyn to,jo Pnasa hEtiirbiB ic.ceh ktiT G waeeDhTlaeeadr nhha aoB,raf Cae,h,t s TreoGolGsenioheeirirrct.oo 2789 GGpFM.lroa eurrMstdgosiaooientro heni,L Ro .. n iSCenPal fmaeSupiSupef-febleTrj rr.e,L a cinttSsswuf isnea,wrn i atEsTrhe.i c HRABui.csm tk,Gi ovoifLtsoyyern n ebtCaetonreld go ,Cr .eG cHlEatuvrateolarl itdeh Cyi,Faor nnucAceehn rtd,.rS -ePTwaCr uhlar Mins.Fst .fi eBnEeran lagsssEhte.er mo,Smpz ,pa rDEkaixarn,-kd 2858 aIISnncmtdhpel rroyofm ev,Sr ecodaan n:nd nT iPuJnoomgth.oen nr tC iWaa.rRl o alG dCrileAii.onn ieiINmrci.amme lru mondAoaupd,p neltDioiecaclantteoii oogEnn.s y Mi fUloserni inRcg,a dJai oorSgiiemn mgAlu. enC-oaCgrhruaaiisqdnu eidlFl vo ,S uaJrnegdfe frreyyy-
2737 MFcamhi2l,y . a TNereews a MFeemrnbaenrde s-oAfl ntehmer iA,p oGpetroatlidc LCitewda-c3k/,I cea ndC yEsmtaedi neS . PArlonteemarsi.e Gene Experimental povennericnnnel Molecular Biology and Genetics
2794 Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hyd b i | itrile} Somatic Mutations Detected by Mini- and Microsatellite DNA Markers
2743 Ovarian Carcinoma-associated TagI Restriction Fragment Length Polymor- Inhibits Cell Growth by Disrupting Mitochondria. Angelika M. Burger, Reveal Clonal Intratumor Heterogeneity in Gastrointestinal Cancers.
phism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Gurmeet Kaur, Michael C. Alley, Jeffrey G. Supko, Louis Malspeis, Michael R. Susanne Nagel, Bettina Borisch, Swee Lay Thein, Madeleine Oestreicher, Fritz
Sequence Insertion. Susan M. Rowe, Sorcha J. Coughlan, Neil J. McKenna, Elaine Grever, and Edward A. Sausville Nothiger, Stefan Birrer, Andreas Tobler, and Martin F. Fey.
Garrett, Dirk G. Kieback, Desmond N. Camey, and Denis R. Headon.
2746 Loss of Wild-Type p53 Bestows a Growth Advantage on Primary Cortical The Interaction of Hydroxyurea and Iododeoxyuridine on the Radiosensi- 2871 Loss of Heterozygosity of Tumor Suppressor Genes in Testis Cancer.
Astrocytes and Facilitates Their in Vitro Transformation. Oliver Bégler, H-J. tivity of Human Bladder Cancer Cells. Mei-Ling Kuo, Keith A. Kunugi, Mary Hong-Qi Peng, Denis Bailey, David Bronson, Paul E. Goss, and David Hogg.
Su Huang, and Webster K. Cavenee. J. Lindstrom, and Timothy J. Kinsella.
2752 OmMv.a enr WeeTxinupemrroe,rs ssLi.oo rniL eKwooifrs n tbhVee.r gO,Fw oecEnadsli, s oAnLd ihHTeu.si iLoiXunu, , aKRniodnl faW siJel. lCir(aapmv1 e2nGs,. * GCAeaKonr)cge e.t itn e InAv. asDienvte, HTui-m AEKnsazttuaitbtolu imsNoihrsm heinoA,tc tiNovafio thNiiBer-so5 0o6Kf-u rboeats aiN,s etwaann dt INnCadegloallh oiLcriaonr ebsSa,az iojSolB.e C -3S/uNbBst.a nFcuem,i hiNkBo- 50K6a,n zawaan,d SGFuaraemnqpgul-eeznsht i bDQyeu t,ae cPtQeiunoagnn tYioetf,a tbXiciiv-ae2 n/-JPYjoa,nl gyT mreaZrhnaassnlego, c aCSthuiasoiannn s HRianel aaHbciut,mi oaannn d ABMselsloaaoyn.di ea WneEdih zrlhOiecrnhg .a Jni ,
Mutations of p/6!™*4/CDKN2 and p15*"*4B/y752 Genes in Biliary Tract
CHiaJrcnhocimediracs h.i SSaudzauoki , YoMsihtisduao, HToarkie,s hiK atTasohdio rokFiuk,a o,Y osMhiahsiatnoa o IcMhiikwaaw,a , anSdh ujKi azHuahniakio, 2814 NMViuevccil,h eaaGnirli sMNmaa gvononef,t Aiccatn idoR neO sfeoorfn atKnhacepe l AannS.tt iundeioeps.l asHtaivca DBreun-gH oLrionn,i daMamriinae :T as>si!nPi ,p a nAdn to‘n3ioc TEFoixxbpirrnoesbs.ls aisTothnso mLaoefs n gaJt. hLDeoengiasen t,iS o DnPe hvaoMsnue t aLa.n ntEd v anIosnf,c rtWeha.es eEsdE w2SaFer1nd s itMTiervraicntesyr c,r tioMp atrSiy oP-nhA ansneF- ascBptjeoocrrin sftiiic,n
and David J. Hall.
Special Lecture 282 N e2r0a-teipoin- Vaintda miInn duDc3er sA naolf oDgiufefse:r enAt iaNtoivoenl oCfl aHsus maofn PoBtreenats t InChainbciteorr s Ceoifl PLrionleisf.-
E‘ena Elstner, Marjane Linker-Israeli, Johnathan Said, Tehila Umiel, Sven de Vos, I. 289 nN Chromosome 9p Allelic Loss and p/6/CDKN2 in Breast Cancer and Evi-
2761 Initiatives with Platinum- and Quinazoline-based Antitumor Molecules— Peter Shintaku, David Heber, Lise Binderup, Milan Uskokovic, and H. Phillip dence of p16 Inactivation in Immortal Breast Epithelial Cells. Andrew J.
Fourteenth Bruce F. Cain Memorial Award Lecture. Ken R. Harrap. Koeffler. Brenner and C. Marcelo Aldaz.
Vili
CONTENTS OF VOLUME 55
2896 A Screening Method to Identify Genes Commonly Overexpressed in Carci- Tumor Biology
Jneonmniafse r anA.d Btyhem e,I denCtaitfhiecraitnei on Toomfa seat tNoo,v elJ eaCno-mMaprlieem eGnatranireyr, DNNicAo lasS eqRuoeunyceer., The a-Glucosidase I Inhibitor Castanospermine Alters Endothelial Cell 2945 Announcements
Marie-Geneviéve Mattei, Jean-Pierre Bellocg, Marie-Christine Rio, and Paul Basset. Glycosylation, Prevents Angiogenesis, and Inhibits Tumor Growth. Roberto Future Annual Meetings of the AACR
Pili, Joan Chang, Richard A. Partis, Richard A. Mueller, Francis J. Chrest, and Call for Nominations for AACR Awards
Antonino Passaniti. Workshop on Methods in Clinical Cancer Research
Seven Megabase Yeast Artificial Chromosome Contig at Region 11p15: AACR Special Conferences in Cancer Research
Identification of a Yeast Artificial Chromosome Spanning the Breakpoint of Recent Deaths
aSV eyrCnodhnrreosoemm,eo .s SohamsMahalis sRiTamtrota anns,N leoCgclraaitunidi,io nne SiFJluvoniuai nend,S abaibnnid o anC ia,Cr alsoM ea Ms.ao tfCa rkBoaec ec.k Owhtiat,h -MWaireida emLauninsa CaHsyTec1sl 0i8Sc0 u.pAp MrPeK-sarszeeughsi urltoah et eTIadnn vaakSsayi,nv teh YePusokitiseh nitodifea lt hIeow faT mtiohsteso u,He umIYnaahsniub miFatosirabs r ooIstfao ,rM ceTotomarlaul oCpIerslholit beaLisihnni-e, Calendar of Events
Yusaku Nakabeppu, Mutsuo Sekiguchi, and Yoichi Sugioka. Employment Register
Topological Control of p2AF1 UCI PI Ey pression in Normal and Neoplas-
tic Tissues. Wafik S. El-Deiry, Takashi Tokino, Todd Waldman, Jon D. Oliner,
Victor E. Velculescu, Marilee Burrell, David E. Hill, Eugene Healy, Jonathan L. Fas/APO-1 Gene Transfer for Human Malignant Glioma. Michael Weller,
Rees, Stanley R. Hamilton, Kenneth W. Kinzler, and Bert Vogelstein. Ursula Malipiero, Anne Rensing-Ehl, Philip J. Barr, and Adriano Fontana.
July 15, Number 14
Advances in Brief Disposition and Metabolism of the Angiogenic Moderator O-(Chioroacetyl- Effects of Radiolabeling Monoclonal Antibodies with a Residualizing lodine
carbamoyl) Fumagillol (TNP-470; AGM-1470) in Human Hepatocytes and Radiolabel on the Accretion of Radioisotope in Tumors. Rhona Stein, David
Allelic Loss on Chromosome 8p12-21 in Microdissected Prostatic Intraepi- TRiashsmuaen i,M icMriochseolm esPl.a ciLdia,u reanntd PJleaacni-dPi,i erErrei kaS oCmrmetatdoons-sSico.t t, Georges de Sousa, Roger M. Goldenberg, SuzanneR . Thorpe, Amartya Basu, and M. Jules Mattes.
thelial Neoplasia. Michael R. Emmert-Buck, Cathy D. Vocke, Rudy O. Pozzatti,
Paul H. Duray, Scott B. Jennings, Charles D. Florence, Zhengping Zhuang, David G. Monoclonal Antibodies against EGFRvIII Are Tumor Specific and React
Bostwick, Lance A. Liotta, and W. Marston Linehan. Carcinogenesis with Breast and Lung Carcinomas Malignant Gliomas. Carol J.
Wikstrand, Laura P. Hale, Surinder K. Batra, M. Leslie Hill, Peter A. Humphrey,
Cell- and Region-specific Expression of Biliary Glycoprotein and Its Mes- DNA Adducts of 2-Amino-3-methylimidazo[4,5-f)quinoline (1Q) in Colon, Shekar N. Kurpad, Roger E. McLendon, David Moscatello, CharlesN . Pegram,
senger RNA in Normal Human Colonic Mucosa. Lars Friingsmyr, Vladimir Bladder, and Kidney of Congenic Mice Differing in Ah Responsiveness and Craig J. Reist, S. Thomas Traweek, Albert J. Wong, Michael R. Zalutsky, and
Baranov, Friedrich Prall, Moorix Mo-Wai Yeung, Christoph Wagener, and Sten N-Acetyltransferase Genotype. Pratibha V. Nerurkar, Herman A. J. Schut, Lucy Darell D. Bigner.
Hammarstrém. M. Andesson, Charles W. Riggs, Elizabeth G. Snyderwine, Snorri S. Thorgeirsson,
Wendell W. Weber, Jerry M. Rice, and Gerald N. Levy
CnFlooedmteaclh.ee rt.i Sohne ngo f Xpi/a5o, anDda izpo1n6g GLein, esJo seinp h PrMi.m aCroyr soNno, n-JSamn alVli jg,C elaln d LuJonnga thCaanr ciA-. cilenamd,iu2cc5 e-dDA inhaCyoldlorogonuxieyc- 16oTf-u emno1era-i,2g23e5-n-yeDnsieih-sy2.d6 r,o2R7xa-ymhveeisxthaa fmliKun.o rWoaDcl3hi,o, l eIMcnaahrilcbc iitfsBe irssoAolzn,on extytame ,e NtohSnahcnaarela--d QoLAiugncnadiinratt eiiwoRt inav toSliomtvfii etnh iM,,e C loAKraamrntoeholllmdaeat ei nMo inCCxe .ol lbns,eB atrwbNreyiae cchncAho niltnaHiisgL, e AnP -.V siCRpnelecsacetsinisffz oio,c I VASCliuylgzetgalioneatn noeoxE ,ix Lcp. rY euTstTosap Lkiaalyoi nma pnKh,aa owncadTyo ktnaRieme sic.,B-.
APC Binds to the Novel Protein EB1. Li-Kuo Su, Marilee Burrell, David E. Hill, Khare, John Hart, Michael D. Sitrin, and Thomas A. Brasitus. Simonis, Steven A. Rosenberg, and Francesco M. Marincola.
Jené Gyuris, Roger Brent, Rodney Wiltshire, Jeff Trent, Bert Vogelstein, and
Kenneth W. Kinzler NFreecqku eTnutm orNosv.e l PiuDsN AM. CBorzpoys kaN, umNibkekri A.I ncLreveians,e Kianr eSn quK.a mFouu, sM icChealell HJe. aKda plaannd, MoleBiocloguy alnd aGenreti cs
Phosphoinositide Signaling in Nuclei of Friend Cells: Tiazofurin Down- Mark I. Singer, Joe W. Gray, and Michael F. Christman. Interferon a-2b and Retinoic Acid Combined Treatment Affects Prolifera-
Regulates Phospholipase C 84. Lucia Manzoli, Anna Maria Billi, R. Stewart tion and Gene Expression of Human Cervical Carcinoma Cells. Francesca
GWielbmeoru,r ,a ndA lbLeurctioo CMoacrcioa. Martelli, Alessandro Matteucci, Silvia Rubbini, George Clinical Investigations RLaonmcielol,ot tia,n d VaGlieorviaan nGii anBadtotmisetnai cRoo,ss i.E lisabetta Affabris, Gianna Fiorucci, Giovanna
Phase I Clinical and Pharmacological Study of Suppression of Human
AIcPensplhbi4eenr,st it toLeasdTu-r -riCe eGllTaSlat TmemMdIi Iml meHhuutnaomin,atd yn A nNttAtMoiT a 2lMK iuagrtjnaDaaetlnfeaetidc n tesnM,r ea ssa Kosa tPrhriCnoeo tlneiMicaonutm trasr.ioen n n,t PA raainn cdRr iHesiKakratv iiojcnaM eonLda,ii nnfdni KaeairCtnsaom rlaioani.nan gAMVauin.nacd tle iinBGmnt.a .eob urKihsVKeaaealzl p aeierlHAol o,inr ,tDt iDhoaibbSnnoauiggdseryaylain ,. B RoKHeoeesslrelpbreoe,yrn ,ts H eaM nFarnrtiaokt hs c MhAoeW.,nh eoTacJellapimopneen,sr a ,lT eL.dD Aednn MntuJii.rs rbC aoolydGl,ryi an ssAe,Lll 6baJe, ar nbti yAc emF aD. Men.oL oxBPyBuusurgzpsldeliaerory-,,, dSTMeooinyymaaoakloti ki.aTc , u mMoMurotstao tkifoor nosmK onoPifas thtiihe,en tAsR ediew intKohim kauFtcahmoiiu-lsYi aanlPo osAlhiydtpeaon,so imsT aatCkooeluois GIePwonalemya p,oi sni asGn.ad s MtMarisocadhhuiiokr-oo
Cancer Patients. Huilian Qin, Wei Chen, Masazumi Takahashi, Mary L. Disis,
David R. Byrd, Larry McCahill, Kenneth A. Bertram, Robert G. Fenton, David J. Genetic Alterations Cooperate with v-Ha-ras to Accelerate Multistage Car-
Peace, and Martin A. Cheever. Endocrinology cinogenesis in TG.AC Transgenic Mouse Skin. David M. Owens, Judson W.
CGPoionrmgdp olnJe iaxnP ge,tSe trsPr,ru icyatanu dr eD aAlyaeanxndaa nndtReher,g uKlSaaemtabni .o nV . ofT atvhtei giPa1n6, (HMaTroSl1d) KLatocchuesr., SDtaevviedn SPtaornrey,, DPKrilosotctkeaeinrnt,. MaAenltdfa rseAdtn atsoHeonsb i sHifcthrt,om mai Zro.Pr raons tCautliicg , CCahrrcisitnioanm aR adEmxapyrre,s s GeAonrdgr oBgaertns ch,R ecHeepltmoutr SAp alGdeinneg, fRoary mSounscde ptWi.b ilTietnnya ntt,o Samnda llR obeIrntt esCt.i naSlm artC.a ncer, ssic], Maps to the
Distal Part ofM ouse Chromosome 4. Remond J. A. Fijneman and Peter Demant.
A Novel p16!NK44 qyanseript. Li Mao, Adrian Merlo, Gauri Bedi, Geoffrey 1. Effect of Aromatase Inhibitors on Growth of Mammary Tumors in a Nude
Shapiro, Christian D. Edward., Barrett J. Rollins, and David Sidransky. Mouse Model. Wei Yue, Jiping Wang, Alexei Savinov, and Angela Brodie.
Tumor Biology
TCMFJM.aouua krutrMaucakishhk taa,utis Atoho.a,in , ,B M aoVrSirbAKtrganiegaraaipnannlh, i ye ans B iSLe.stACh e ..bp ahWoRkLaefuihnb bVtieio,ertln ,hs,ei AP ,.aa tLnBrKoAdiirR ncniiCgdJ a.erA f efJS Ew.B . e B tohFWMyG rd.ceiA. Gne nodeMnvm e eannrRzi,nein ,bn a ,n OMevaH,Prsa ayiru-uAilC-n alCnnCahm .iia rarenLCi igaeu n ,cK CCieIhanrvirgsoud,.r,o niBMFceHaeknisr,jrga aoukmyJsuiuo nknhii,nJ . TLR.ha ecGkrr aepcooyf, RoeSftc eiPppahrneoEcncrx ietOpay.te iNrciu nir sADmedr-eeFuinngno tlcaaaayn,rld c iJLonihTognhmh taeC .r DiaPonas preVse iotnuDrsoe,t. p ieaKcnn.dd s eT Tnhhocomema asso f MSPo.eh soMttaaon,g d.yW nilalmiiacm OWRMVr..ie ac telTiW. hn. ooS miDqa.dLu z-aRayim..npm dhoSu,huca sle iRd.n sCkeASyl.u,l p HpECer.ay eDmrs.acs niiB,oni nsoc mMhao.of ff ,AXS .e qMnuS.oha igmLrr.loa eufGy.trs es g To.Cr( eyLl,iAl n .eMC D .oi of1kfM4ee.8,r 3 e)Gn oPtt.iit anaJr t.diA ioAts.n,h yDJmia.ni v Sic.He suH,Nam yuaeadsnne,d
LU103793 (NSC D-669356): A Synthetic Peptide That Interacts with Micro-
Definition and Refinement of Chromosome 11 Regions of Loss of Heterozy- tubules and Inhibits Mitosis. Monika de Arruda, Celia A. Cocchiaro, Christine M. Establishment and Molecular Characterization of a Novel Leukemic Cell
gosity in Breast Cancer: Identification of a New Region at 11q23.3. Massimo Nelson, Christine M. Grinnell, Bernd Janssen, Andreas Haupt, and Teresa Barlozzari. Line with Philadelphia Chromusome Expressing p230 BCR/ABL Fusion
Negrini, Debora Rasio, Garrett M. Hampton, Silvia Sabbioni, Shashi Rattan, Stephen Protein. Hiroshi Wada, Shuki Mizutani, Junji Nishimura, Yuko Usuki, Masatoshi
L. Carter, Anne L. Rosenberg, Gordon F. Schwartz, Yosef Shiloh, Webster K. Induction of Apoptosis by 5-Azacytidine: Drug Concentration-dependent Kohsaki, Masumi Komai, Hideo Kaneko, Shunji Sakamoto, Domenico Delia,
Cavenee, and Carlo M. Croce. Differences in Cell Cycle Specificity. Tomoyuki Murakami, Xun Li, Jianping Akihisa Kanamaru, and Eizo Kakishita.
Gong, Umesh Bhatia, Frank Traganos, and Zbigniew Darzynkiewicz
wZAAhincitttlhiii vcnatagth neicG oeanUro n, no AafCc thttuhiurevna igltT y a Km1..oo fCxC oiBhnfu-fe,.i n-gD uainrDodaex troiYilouvannan.gte i--vCKcehry iits MitiedCetih aneLben.o,g l G.ir otav eNe o,vE e Xltio n NFGuoucrolm,e osSDihNdweAu -HAAundeadylu ocgtLusiue:, aALFcerndtadbni ecvtiitsOtecytro h,, e orfa Lniads BaSC -ilLnaKigy.n leeBGa-.ig ClelhSi ialeiagnnaCdl e,ll. lI smM maurEnkx optrRoe.sx siiSntn egb Tbihnatsth,e SNeCalDnec4cty0i veAlA.y n tNiKoigrlerlnis.s , LyJJomefspferhpehoy maAA.. aARDnaenndcdi ereploBt gioenBr.dn. i RnuAgkUb sptr-aAalRfhifesaig.nmu i ltayL t. eisBn r aPsEsC,p3 i dJoCeehrlnml a lBLa irnnGearrsd o,w EtxhBpa rrebsFasariac ntogLr . tPhRaeet aciHe, putmDoearbn r a ExASpnarldveris,os giaeonnnd
Comparison with the Adducts Formed by Microsomal Activation of Tamox-
ifen. Krisztina Pongracz, Deena N. Pathak, Takemichi Nakamura, Alma L. Gene Therapy for Hepatoma Cells Using a Retrovirus Vector Carrying Nonrandom Chromosome Abnormalities in Short-Term Cultured Primary
Burlingame, and William J. Bodell. Herpes Simplex Virus Thymidine Kinase Gene under the Control of Human Squamous Cell Carcinomas of the Head and Neck. Yuesheng Jin, Fredrik
a-Fetoprotein Gene Promoter. Akio Ido, Keisuke Nakata, Yuji Kato, Kazuhiko Mertens, Charlotte Jin, Jan Akervall, Johan Wennerberg, Ludmila Gorunova, Nils
Nakao, Ken Murata, Masatoshi Fujita, Nobuko Ishii, Taiki Tamaoki, Hiroshi Shiku, Mandahl, Sverre Heim, and Felix Mitelman.
Regular Articles and Shigenobu Nagataki.
Antineoplastic Drugs Sulindac Sulfide and Sulfone Inhibit Cell Growth by Virology
Inducing Apoptosis. Gary A. Piazza, Alanna L. Kulchak Rahm, Mary Krutzsch,
Biochemistry and Biophysics Gerhard Sperl, Nancy Shipp Paranka, Paul H. Gross, Klaus Brendel, Randall W Impairment of Moloney Murine Leukemia Virus Integration in a Cell Line
Enhanced Expression of Calreticulin in the Nucleus of Radioresistant Squa- Burt, David S. Alberts, Rifat Pamukcu, and Dennis J. Ahnen. UHénldéenree xGporuelsaosuiincg, SDanNdAr ineT oCpaortiesaoum, eraands eC hriIsl.t iaPna scAaulclea irB.o uillé, Frédéric Subra,
mViocuesn teC aNroctairnioo,m aa ndC elAlnsa toiln y ReDsriptosnchsiel o. to Ionizing Radiation. Priya Ramsamooj, Ainp oSptqousaimso uIsn duCcetlilo n CaMrecdiinatoemda boyf Wtihle d-HTeyapde apn5d3 ANdeecnko.v iTraa-lJ enG enLieu , TrAadnesl feKr.
Spyenrtihdeisni-s4 -aynld) -4P-hiaordmoabceonlzoagmiicdae:l CAh aHriagcht erAifzfiantiitoyn oo fR 4e-c1ep2t5o 1r} -LNi-g(aNn-Bde nfzoyrl pPio-- aEnld- NaGgagrayr , L.T iCmloatyhmya n.J . McDonnell, Kim D. Steck, Mary Wang, Dorothy L. Taylor, AFuntunreo uAnnncuealm eMnetetsi ngs of the AACR
tential Imaging of Breast Cancer. Christy S. John, Bertold J. Vilner, Mary E. Call for Nominations for AACR Awards
Gulden, Simon M. N. Efange, Rosemary B. Langason, Terry W. Moody, and Wayne Immunology Workshop on Methods in Clinical Cancer Research
D. Bowen. AACR Special Conferences in Cancer Research
Direct Correlation between Expression of Endogenous Inducible Nitric Ox- Calendar of Events
Impairment of the Mitochondrial Respiratory Chain Activity in Diethylni- ide Synthase and Regression of M5076 Reticulum Cell Sarcoma Hepatic
trosamine-induced Rat Hepatomas: Possible Involvement of Oxygen Free Metastases in Mice Treated with Liposomes Containing Lipopeptide CGP
Radicals. Eric Boitier, Mansouria Merad-Boudia, Christiane Guguen-Guillouzo, 31362. Keping Xie, Suyun Huang, Zhongyun Dong, Mordechai Gutman, and Isaiah
Nicole Defer, Irene Ceballos-Picot, Jean-Paul Leroux, and Cécile Marsac. J. Fidler.
August 1, Number 15
Advances in Brief Induction of Programmed Cell Death in Human Breast Cancer Cells by an Novel Suppressor Loci on Chromosome 14q in Primary Bladder Cancer.
Unsymmetrically Alkylated Polyamine Analogue. Diane E. McCloskey, Robert Wayne Yen-Hwa Chang, Paul Cairns, Mark P. Schoenberg, Thomas J. Polascik, and
A. Casero, Jr., Patrick M. Woster, and Nancy E. Davidson. David Sidransky.
Suppression of Tumor Growth in Vivo by Local and Systemic 90K Level
GIenrcmraeianse,. JolBaanhtiaj aJ acJoalblsa,l , StJeefffa noP owlaeclolb,e lliJ,o saenpdh AZxaeclh wUileljraic,h . Cord Brakebusch, Linda CCEraoirmco plAyl.ne xSAt .ra RuFesespl,li xi.Mc aatttihoenw ERr.r oHro slCear,u sPehsi lipp5 3H erMzuotg,a tiKoevni n inS aal hLaniy-,F rRaounmaledn i LouFiaem,i layn.d pCWeieli6l-' WNeC iy c4lZ ehG aenngAe,r reAMstehtda niaaastsneiddo s IbPny.h iKabynri ittiAsoidnse, n oaonvfdi rJTuasuc km oVAre.c tRoorCte.hl. l XiaPormoelii feJrina,t iDoano Nbgyu yetnh,e
Gelsolin: A Candidate for Suppressor of Human Bladder Cancer. Motoyoshi Defective Induction of Stress-activated Protein Kinase Activity in Ataxia-
Tanaka, Leonhard Miillauer, Yoshifumi Ogiso, Hisakazu Fujita, Shingo Moriya, Keiji Telangiectasia Cells Exposed to lonizing Radiation. Timothy D. Shafman, Ectopic Expression of Carcinoembryonic Antigen by a Melanoma Cell
Furuuchi, Tohru Harabayashi, Nobuo Shinohara, Tomohiko Koyanagi, and Noboru Ahamed Saleem, John Kyriakis, Ralph Weichselbaum, Surender Kharbanda, and Donald Leads to Changes in the Transcription of Two Additional Cell Adhesion
Kuzumaki. W. Kufe. Molecules. Thomas Grimm and Judith P. Johnson.
1X
CONTENTS OF VOLUME 55
3258 Telomerase Activity in Gastric Cancer. Eiso Hiyama, Takashi Yokoyama, Experimental Therapeutics Base Transitions at CpG Dinucleotides in the p53 Gene Are Common in
Naokuni Tatsumoto, Keiko Hiyama, Yuji Imamura, Yoshiaki Murakami, Takashi Esophageal Adenocarcinoma. Catherine M. Gleeson, James M. Sloan, James A.
Kodama, Mieczyslaw A. Piatyszek, Jerry W. Shay, and Yuichiro Matsuura. 3339 Bystander Killing of Melanoma Cells Using the Human Tyrosinase Pro- McGuigan, Andrew J. Ritchie, and S. E. Hilary Russell.
moter to Express the Escherichia coli Purine Nucleoside Phosphorylase
3263 CEYaxasprurcneiosnrsio imoaOnks a.do af. H iidehigroN HiMraosthrii xS atMoe,t aMloltoophraortue iSneaiksie, Mina sHayuomsahin MGaais,t raincd 3346 GIE.fe fGnaeerc.vt e rBo,rf i aJHrn.i ,g WWh.i- lIlHniutagemhn essBi,.t yPA alraFkneo rc,Hu .s aenWdedl lEsUr,li ct ZrsJa.u szSosoaur sncdBhe ebroo.kn , HVuijmaaynak riPsrhonsat aKt.e GaCdai,n cReorb eritn 3412 AAZHKda nazzmeiNisemmentiiiweeac rrk za C.C oCeSlemtllupsldi. z eiMamPnuei,te ntateLnraa ttusTri eaol lnTeWh meatatGsn e,rl oCaaluWroip,sl ehleAoyldf m aiyRMnaeiaps taeolJmm.ab yml1c .e isOTn. v etrNChak-eta ahmrypPapj,hea enrn,sN oeotnuaysncpdih teai Mvaoevlfa gn o rFCzahWanietscnasoe enslieZ,.
3267 Functional Evidence that Cell Surface Galectin-3 Mediates Homotypic Cell Vivo. Stephan Madersbacher, Markus Pedevilla, Lorri Vingers, Martin Susani, and
Adhesion. Hidenori Inohara and Avraham Raz. Detection of Cancer Micrometastases in Lymph Nodes by Reverse Tran-
scriptase-Polymerase Chain Reaction. Masaki Mori, Koshi Mimori, Hiroshi Inoue,
3272 Csioomn plaenxd RMeagturliaxt ionM etoafl lMoepmrborteainnea-seT-y2p e AcMtaitvraitxi onM etbayl loCpornoctaenianvaaslei nE xpAr esi-n 3352 C2a-tAhmeirnion-e6U -.m Leatmhboex,y pDuervironne RA.r aAbveirneotts,i deM:e laAnni eAT g.e nPatf f,f oJro hTn- mE.g R eMaradloing,n aJnocaine sG.. GAkriayhoashmi . F. Barnard, Koichi Tsuji, Shigeru Nanbara, Hiroaki Ueo, and Tsuyoshi
SMeDikAi,- ManBd- 2Er3i1k W.H uTmhoamnp soBnr.e ast Cancer Cells. Ming Yu, Hiroshi Sato, Motoharu Wilson, and Thomas A. Krenitsky. MUuptpaetri oDni geFsrtievqeu eTnrcayc t.o fH itrhoey apsu/ 6I/gaCkDi,K NHi2r okiG eSnaesa kii,n YPujrii mTaacrhyi moCria,n ceHorisc hii nK attho,e
Increased Antitumor Activity of a Circularly Permuted Interleukin 4-Toxin Hiroshi Watanabe, Taizo Kimura, Yukio Harada, Takashi Sugimura, and Masaaki
Regular Articles iKnr eiMtimcaen , wRiatjh K.I nPtuerri,l eaunkdi nI ra4 PaRsetacne.p tor-bearing Human Carcinoma. Robert J Terada.
Tumor Biology
Biochemistry and Biophysics Immunology 3424 mInacnr eaBsreeda stL evCealrsc ionfo mGalysc.o prDoavtiedi nsE. CSloenatt,a iTnsiunegy -LMiangn noChseen , 6K-aPrheol spRhasaktae, Jirn. , Haun-d
3278 High Ky, Glucose-phosphorylating (Glucokinase) Activitie: in a Range of Immune Sera and Monoclonal Antibodies Define Two Configurations for Peter Lobel.
TNEeunwmzsoyhmroel m CeeI.ln lh iLbiinteosr aMnadn noInhheipbtiutiloons eo.f RMaatreys Boofa rTdu, mAolris onG rCoowltqhu hobuyn, thaen dS pEencci fiAc. tSLhtoeen vgeSenin aelcHyk.!e rTI,tn z kKoTewunintmzeo,t rh R.OA .n RtaLilogo eyndK,.o gaaSnnhtdey n,Pg hlieMl iaZpr hkOa .n gR,Le idvdLiiinsnghds,at onAS..h aWmal beS.r gG,a nSdhhuin,i chBi.r oM iOcghaateal, CERefilfclehsca.tr sd oCfBh. a SotWxeiilmad nerCge, l lS ahnFudia ,c tSouWrsaa qnoq na Jr.t hKenB .oG xr.Ko hwatnh, aBnrdy anR adRi.a tLieoing h,S urAvninvea l Mo.f TTuurmnoerr,
3286 Metabolic Characterization of Human Non-Hodgkin’s Lymphomas in Vivo 3369 In Vivo Antitumor Activity of T Cells Redirected with Chimeric Antibody/ 3438 Autocrine Growth of Transitional Cell Carcinoma of the Bladder Induced
with the Use of Proton-decoupled Phosphorus Magnetic Resonance Spec- T-Cell Receptor Genes. P. Hwu, J. C. Yang, R. Cowherd, J. Treisman, G. E. Shafer, by Granulocyte-Colony Stimulating Factor. Masaaki Tachibana, Ayako
troscopy. William G. Negendank, Kristin A. Padavic-Shaller, Chun-Wei Li, Joseph Z. Eshhar, and S. A. Rosenberg. Miyakawa, Hiroshi Tazaki, Kayoko Nakamura, Atsushi Kubo, Jun-ichi Hata, Tatsunari
Murphy-Boesch, Radka Stoyanova, Robert L. Krigel, Russell J. Schilder, Mitchell R. Nishi, and Yasuhiro Amano.
Smith, and Truman R. Brown.
3374 Overexpression of the T-Cell Receptor B-Chain Variable Region TCRBV14 The rck/p54 Candidate Proto-oncogene Product Is a 54-Kilodalton D-E-A-D
3295 TiNzhuacetl ieoFnaa.rr nMeLasarygm!ui enrPsirt oet aeniBd.n DTpalr2tao1nns," f eKrebalulstee y DISon.e hsFi abnitNtlooet,r HABefZaftAehc-etr5 BTA h.e BilBreo cchkFtsou lndFc,at riLnouencs aysol ra DteiLMooacnia olo,-f iSAntne ifcHahLniinAai- , ARa2Col-,am uadFiltaocv ihCoel edAmr eienPnttrei,i, mMaGiarosyrs giiHmouo mPaSaarnrmti oarniMi,e , lGiaaonnrdog miMoaa srB.ira altuSiitnseaaf, a nESineanr siiSc.aol viC,a rFoanbniio, SAengdalrleaa, BAHakocaxho i,yP arO,os taeaminund YDMoiasfrhfuiekhriaedwneat ,ia TlsHluiyjri omsEohtxiop .r Meosrsiekda wai,n HKeuimicahin Naaknado , MoMuiskaek oT iKsasmueeis., TYaukkaihhiisrao
Robert M. Evans, Alphonse Krystosek, and Michael Sinensky. Antitumor Effectiveness of Electrochemotherapy with cis-Diamminedichlo-
Molecular Biology and Genetics roplatinum(II) in Mice. Gregor Sersa, Maja Cemazar, and Damijan Miklavéi¢.
3305 PPautlimenotnsa:r yA ssEoxcpiraetsisoin onw Citoahf r GGclSiuTtnaMto/hg ioePnneo leySsm-oiTrrspa hnissfemr,a seS moMk3in gi,n Lanudn g AsCbaenscteors 3380 CASamhrpralhoi mfLio.c saAotnmizoiecn k , iMniF clHoruyomdd iasHn.s eTcOhtvoiamorpnis aonnI ,d eCnaPtariufclii ensSo . mMaCer.ly tpzeXtrii,nc - MYiSuciahtnae esGl u aoLnf., DBCiNottlAnye nr, SBR.e aqCyuarmegoninclede, 3456 IwMidiletlnhet r,i fMiGacelanitegi onnHa .n taB namdeT trtCa,hn asJrfoaoscertpmehar tiFiz. oaHntai honn,i n aonAfds tHBruroymcaayntn o Rm.a £G.2. - CWShihliilmxiiaanmegsr .i nYu:a n,A ssDoacviiadt ioWn.
Exposure. Sisko Anttila, Leena Luostarinen, An Hirvonen, Eivor Elovaara, Antti Taetle, John R. McGill, and Jeffrey M. Trent.
Karjalainen, Tuula Nurminen, John D. Hayes, Ham Vainio, and Brian Ketterer. Meeting Report
3386 Maintenance of Normal Imprinting oi H/9 and IGF2 Genes in Neuroblas-
3310 Latent Expression of p53 Mutations and Radiation-induced Mammary Can- toma. Makio Wada, Robert C. Seeger, Hideaki Mizoguchi, and H. Phillip Koeffler. 346 Nw Sixth Annual Pezcoller Symposium: Normal and Malignant Hematopoie-
cer. Christy S. Selvanayagam, Claude M. Davis, Michael N. Cornforth, and Robert L. sis—New Advances. Enrico Mihich and Donald Metcalf.
Ullrich.
Suppression of Malignant Phenotype in a Human Prostate Cancer Cell Line
3318 Stayrnye rgAifsltaitco xiHne paBtyo cainr cWionoogdecnhiucc ksE.ff ecPt. oBfa nnHaespcahd,n avN.i raImla niI nfKehcotsihokn hoaun,d HD.i e-J. bAryt hFurr aRg.m eBnrottsh maonf, NRoorbmianl J. CLhearcohm, oasnodm aRlay moRnegdi oLn. W1h7itqe.. Yoshinori S. Murakami, Announcements
Hacker, S. Radaeva, M. Mrozek, U. Zillmann, A. Kopp-Schneider, U. Haberkorn, Future Annual Meetings of the AACR
M. Elgas, T. Tolle, M. Roggendorf, and I. Toshkov. Identification of Multiple Breast Cancers of Multicentric Origin by Histo- Workshop on Methods in Clinical Cancer Research
logical Observations and Distribution of Allele Loss on Chromosome 16q. AACR Special Conferences in Cancer Research
Hitoshi Tsuda and Setsuo Hirohashi. Recent Deaths
Endocrinology Calendar of Events
3331 Changes in Estrogen Receptor, Progesterone Receptor, and pS2 Expression 3399 Allelotyping of Ductal Carcinoma in Situ of the Breast: Deletion of Loci on
in Tamoxifen-resistant Human Breast Cancer. S. R. D. Johnston, G. Saccani- 8p, 13q, 16q, 17p and 17q. Diane M. Radford, Keri L. Fair, Nancy J. Phillips, Jon H.
Joti, 1. E. Smith, J. Salter, J. Newby, M. Coppen, S. R. Ebbs, and M. Dowsett. Ritter, Todd Steinbrueck, Matthew S. Holt, and Helen Donis-Keller. 3470 Author Index
August 15, Number 16
Advances in Brief Regular Articles Immunology
A Human Monoclonal Antimelanoma Single-Chain Fy Antibody Derived
Duplication of N-MYC at Its Resident Site 2p24 May Be a Mechanism of from Tumor-infiltrating Lymphocytes. Hua Zhang, Douglas F. Lake, Jose
Activation Alternative to Amplification in Human Neuroblastoma Cells. Biochemistry and Biophysics Alexandre M. Barbuto, Ralph M. Bernstein, William J. Grimes, and Evan M. Hersh.
Raffaella Corvi, Larissa Savelyeva, and Manfred Schwab.
3475 CHhetreornoigce nLeiytmyp hoofc yDteilce tiLonesu keInmvioal viRnegv eRaBl-e]d abnyd Flthueo rDe/sc3eSn2c5e Lino cSuist u inH yBb-rCiedl-l 3525 tEPi.na lhBlauy ndecB,el odEc dkweHader pdab tyi McA. ntCAiompbieonldoayn d,tAo c iaTdnu dm ToWrrial nesNype ocWrr.ot s iSsio nu bFaTa.uc tmoorr.- bYeoasrhiifnugm i RIantosu e,I s BaPrarri-e aPIc rttoaixdv.u actNtiaioonok ni ofoM fot rhIie,n tIeSnrhtlueeirculhkeiiu nk Miun8r ai8nk aGAmediun,le t SbuTys- uCHemluul m aOLdnea ,u kT-DeiCmaeinlael PLCreealugleksr:e, m Piaonasd s iVSbiulrmeu isyT arT aynEpsto-e.
ization. Stephan Stilgenbauer, Elke Leupolt, Sybille Ohi, Gunther Wei8, Martin
Schréder, Konstanze Fischer, Martin Bentz, Peter Lichter, and Hartmut Dohner. Carcinogenesis Admixture of a Recombinant Vaccinia Virus Containing the Gene for the
Costimulatory Molecule B7 and a Recombinant Vaccinia Virus Containing
3478 Identification of MAGE-1 and MAGE-4 Proteins in Spermatogonia and Metabolic Activation of N-Hydroxyarylamines and N-Hycroxyarylamides a Tumor-associated Antigen Gene Results in Enhanced Specific T-Cell
Primary Spermatocytes of Testis. Koichi Takahashi, Shigeki Shichijo, Masanori by 16 Recombinant Human NAT2 Allozymes: Effects of 7 Specific NAT2 Responses and Antitumor Immunity. James W. Hodge, Joanne P. McLaughlin,
Noguchi, Masaru Hirohata, and Kyogo Itoh. Nucleic Acid Substitutions. David W. Hein, Mark A. Doll, Timothy D. Rustan, Scott I. Abrams, W. Lesley Shupert, Jeffrey Schlom, and Judy A. Kantor.
and Ronald J. Ferguson.
Cytochrome P4501A1 and Glutathione S-Transferase (M1) Genetic Poly-
morphisms and Postmenopausal Breast Cancer Risk. Christine B. Ambrosone, Molecular Biology and Genetics
JHBoar arsrLui.rn eg,Ft rone,uR doeTsnrehamecaiermyy, D.S LaaFxuoogrnhd l,i nGa,rn adh aTPmae,tk eurm JaGa .m esSN heimeRlo.d tso M,a rshAarltlh,u r JohMn. E.M icVheanlae,k , JohAnn itRa. Polyadenylation PolymoErpphiisdme miin otlheo gAcye tyltransferase 1 Gene (NAT/) pl5ec3u laMru tEavtiidoennsc ei nf oNr oFnimeeldl aCnaoncmear izSaktiino n.C anSacgearr ikoaf Ktahnej ilHale,a dS araan dS. SNweockm:, GMaor-y
Increases Risko f Colorectal Cancer. Douglas A. Bell, Elizabeth A. Stephens, L. Clayman, Randal S. Weber, Adel K. El-Naggar, Vivek Kapur, Kathleen K.
TAhntei geInn duFcotrimonu latofi onC.y toKtoaxnidca saTm y CeHlalrsi haarnadn , TGuamroy r BraRselgarwessksyi,o n Ameblyi a SoBlluabclke, TCr. isHhean drCiacsktrsaen,i o,H amDiasvhi d DuMn.c anU,m baacnhd , RiMchaarryd WCa.t sSotnra,n geM.a rk Deakin, James Elder, CN.u mAmnianngtsh,a sLweaimgyh. Anne Hill, Margaret R. Spitz, Margaret L. Kripke, and Honnavara
Syamal Raychaudhuri, and Nabil Hanna.
3610 Aberrant Expression of the Myeloid Zinc Finger Gene, MZF-1, Is Onco-
3490 rMeicctraoli nCjaerctciionno moaf MCoelnlosc lRoensatlo reAsn tithbeo dTyr anPsAcbr4i2p1t ioinn toA cHtuivmaatnio n SWF4un8c0t ioCno lot-o 5-Ethoxy-2'-deoExxyupreidriinem,e na tNoavlel STuhbsetrraatpe efuort iTchysm idine Phosphorylase, gDeanviicd.s oRno,b erMti chHareolm asS,ha ,J eGnneiofregre MoSrlreidsg,e ,K eannnde tFhr aCnokr eRtatuas,c hDeoru gIlIaI.s Berebitsky, Amy
3495 MNAeubrtei.ra rnatn tp 53E.x pPraetsrisciioo n Aboarfz ituhiea, GJrooswepthh E.F aLcotSoarr doW,n tM-a5rAy iLno uH uGumbalenr , Maanldi gAnnatnhcoyn.y PnEA.oad ttweiOatnorttndei r a.wt Lie.ts h S ctIhhwneat retArzfn,et rioNtniu,cm oolaern BIAancpdttiiusvctieet.ry Soorffe eT5nhi-yvFamlsuiaodlriuo nueMr eagcPaihtlio ,s pWShhcooertnty lWaUassdele edr E,x ipnar neCdso smBibroiina-.n aCCo-hrFrreoetlmoapotrsioootnme ein w i1(t4hA. F PLte)hi el aE OxKpchrcaeumsrzsriienonanc, ei Tna otCfjl aonHnaoe smE oragoifes enMre,co Aua-sndlR yHP ierS7rt7ea7 i7Bn oirRngaget a tR.He egpiaotnosm ao:n
Renato V. lozzo, Inge Eichstetter, and Keith G. Danielson.
PCKoaeinrnzctoi nMoKumotabaa.ty iaosAhnki i,ho ifrY ooO srhnTiaihmtiohsriain ,e Y aSnDhoeu,ch eaira nbdoN xiSyshhluiazgsuoec hOiGt,ae nniTe.e tsiuno HuKumraokni , HeNopraittoocsheil luKloahr, 3551 TBBKoeiusnsrhnpdieheytonuhsk ip ihRno.Y noBanWoterdeina ge.h tRi,ni seNMduarrdoken atCMeih caep.Rm eadnAu,kic reasR ogSaeMsleaytk ia,s BtoaBytrcieecn, d anHG ruemFg.ao rnBy o ycBRe.r, e aMsButer nyd!yC ,a Sntcoaernyrd, 3623 AnKanoneutzm oiN ae-Hoiiprnaldia,u scmSishni.ng - iKcSehnui-b iscNthaaikT natcHuaeo, mn dofTaro,ros h mOi syBPuailkmiauo s lmSIaous mhgiio,kyf o ,TP aoItcmihoeirynoto s T aYtwasisututhia ,, AMadnavdsa anaSckaiec hdi Doe MgaOuglciihtgia-,.
3504 B-Adrenergic Mitogenic Signal Transduction in Peripheral Lung Adenocar-
cinoma: Implications for Individuals with Preexisting Chronic Lung Dis- 3558 Regressions and Cures of Melanoma Xenografts following Treatment with 4 4 Inhibition of Organ Invasion by the Matrix Metalloproteinase Inhibitor
ease. Paul G. Park, Joice Merryman, Michael Orloff, and Hildegard M. Schuller. Monoclonal Antibody B-Lactamase Conjugates in Combination with Anti- Batimastat (BB-94) in Two Human Colon Carcinoma Metastasis Models.
cancer Prodrugs. David E. Kerr, George J. Schreiber, Vivekananda M. Vrudhula, Susan A. Watson, Teresa M. Morris, Graham Robinson, Michael J. Crimmin, Peter
3509 Thrombopoietin Receptor Expression in Human Cancer Cell Lines and Hakan P. Svensson, Ingegerd Hellstr6m, Karl Erik Hellstrém, and Peter D. Senter. D. Brown, and Jack D. Hardcastle.
Primary Tissues. Lucia Columbyova, Massimo Loda, and David T. Scadden.
3513 Cell-type-specific ras Mutations But No Microsatellite Instability in Chem- Rroelsep onosfe Rbeyo xyPgaeclniattaixoeln. iLnu kIa nduMciltaiso,n Noafn cyE nhRa.n cHeumnteenrt, Koaft hTryunm orA. RMaadsioon-, ERaxtp reMsessiootnh eloifa lIn sualnidn -lSipkeo ntGarnoewotuhs FaMcetsoort hIeIl iino mSap onCteallnse:o usAl yP otIemnmtoiralt alAiuzteod-
ically Induced Mouse Skin Tumors and Transformed 3T3 Cells. Kiyoshi Christopher G. Milross, Yoshihiro Saito, and Lester J. Peters. crine Role of Insulin-like Growth Factor I. Alphons A. J. J. L. Rutten, Edilberto
Sasaki, Olivier Bertrand, Hisayoshi Nakazawa, D. James Fitzgerald, Nikolai Bermudez, Wendy Stewart, Jeffrey I. Everitt, and Cheryl L. Walker.
Mironov, and Hiroshi Yamasaki.
3517 HDeuamtahn InPdruocsetdat icb y Ctahnec eArn tiCaenlglsi ogAernei c SeAngsietnitv e Litno omPirdoeg. raJmamsmeidn ka (AVpuokpatnootviicc) GFMlaaorlvnieergs,n yalnBtterr anndPs hfeRe.nr oaStseyeip zein.Ign ehri,Nb iinatgno dr sY VaenBe,l roacCskaw raotmlhyyen NMeRaiuncrnceoa.f, ibJroonmaathtaons isF letTcyhpere, IT h(oNmFa1s) iIBsintltilcrasod deauoucf, t itoDhnie anoIefn taFe.nr lJeAeulciktniienvk ,a t6eNd-i dsheNap- ernSahdsa ehnO,t n cTuoMcgykeeenrle o Wm.Aa l tLeerCBsei leltn h,e L iaGnnredo wBAtrNihaB nL C6hV.aa rn acDNatenesisre.-l
and John T. Isaacs.
3576 Apoptosis and Altered Redox State Induced by Caffeic Acid Phenethyl Ester Adhesion Molecules on Human Myeloma Cells: Significant Changes in
3521 TGaekramslhii neF ukMuuttoamtii,o n Toosfh iBkRaCzuA / Usihni jJiampaa, neYsoes hiBrroe asMta tCsaunmcoetro, FaTmaiklaisehsi. RSiueg iImnuoruae,, C(aCrAotPhEe)rs , inD ezTirdearn sGfrournmbeerdg er,R atG reFgiobrryo blSaoslto moCne,l lsG.l orCihai aA . ChPiraesot,o n,A daenlda idJe. CaMr.l a CEaxtphreersinsei onP eRlellaatt-eDdec etuon yMnaclki,g naSnopchyi,e TBuamriolrlé , SpDreenaisd inPgu,t hiaenrd, IMmamroire-tJaolsiéz atRiaopnp.,
and Minako Nagao. Barrett. Jean-Luc Harousseau, Régis Bataille, and Martine Arniot.
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