Cancer Research 2000: Vol 60 Table of Contents

25 Pages·2000·9.8 MB·English

Contents of Volume 60
January 1, Number 1
Editorial Identical Clonality of Sporadic Gastrinomas at Multiple Sites. Stephan | iated Inactivation of pl4*RF js Indepen-dent of
Goebel, Alexander O. Vortmeyer, Zhengping Zhuang, Jose Serrano, Robert T pi6!NKda My ethylation and p53 Mutational Status. Manel Esteller, Silvia
1 Cancer Research for the New Millennium. Frank J. Rauscher, III Jensen, and Irina A. Lubensky TBoarytloilna,, anMdi noJraum es ToGy.o taH,e rmGaanb riel Capella, Miguel Angel Peinado, Stephen B
N-Myc Induction Stimulated by Insulin-like Growth Factor I through Mi-
Advances in Brief ttoogmean -aCcetllisv.a teAdk ikPor otMeiisna waK,i naHsaej imSei gnHaolsioin.g PAkaitkhow ayA riimno toH, umTaank umNae urSohbiklaatsa.- Tumor Biology
Shinji Akioka, Takafumi Matsumura, Peter J. Houghton, and Tadashi Sawada. B1,6-N-Acetylglucosamine-bearing N-Glycans in Human Gliomas: Implica-
2 Therapy of Human Pancreatic Carcinoma Implants by Irinotecan and the tions for a Role in Regulating Invasivity. Hirotaka Yamamoto, Jason
Oral Immunomodulator JBT 3002 Is Associated with Enhanced Expression A Distinct Tumor Suppressor Gene Locus on Chromosome 15q21.1 in Swoger, Suzanne Greene, Tasuku Saito, Jay Hurh, Charla Sweeley, Jan
of Inducible Nitric Oxide Synthase in Tumor-infiltrating Macrophages. Sporadic Form of Colorectal Cancer. Won Sang Park, Jik Young Park, Ro Leestma, Edward Mkrdichian, Leonard Cerullo, Atsushi Nishikawa, Yoshito
Christiane J. Bruns, Hisashi Shinohara, Matthew T. Harbison, Darren W Ra Oh, Nam Jin Yoo, Sug Hyung Lee, Min Sun Shin, Hun Kyung Lee, Ihara, Naoyuki Taniguchi, and Joseph R. Moskal
Davis, Gina Nelkin, Jerald J. Killion, David J. McConkey, Zhongyun Dong. Seoyoung Han, Sungjoo Kim Yoon, Su Young Kim, Chan Choi, Pum Joon
and Isaiah J. Fidler. Kim, Seong Taek Oh, and Jung Young Lee c-Myc Suppresses the Tumorigenicity of Lung Cancer Cells and Down-
Regulates Vascular Endothelial Growth Factor Expression. Linda F. Barr
8 pMhuatraytnigoenas l inC atrhec iRneotmian.o blPaisert omPaa-olroe laCtleadud ioG,e neC anRdBa2c/ep /3M0. iHno wParridm,a ryY anN asFou-, Regular Articles SHuysuanns ukE. SChaimmp,b elaln,d CGhrie goV.r y DaBn.g Diette, Edward W. Gabrielson, Sunkyu Kim,
CCaaptuetrii,n a anCdi ntAi,n tonLiuoi giG ioCraldiafnaon o, Pietro Micheli, Edward W. Mercer, Mario tHhiegliha l LevOevlasr ioafn StCraonmcaelr . HyaMalaurrito nanA. PrAnetdtiilcat, PoRoarij a DisHe. aseT aOmmuit,c omMea rkink uE pi-[|
Carcinogenesis Tammi, Kari J.S yrjiinen, Seppo V. Saarikoski, and Veli-Matti Kosma
13. Molecular Cloning and Characterization of Human MAWD, a Novel Protein
Containing WD-40 Repeats Frequently Overexpressed in Breast Cancer. Org: ific, Carcinogen-induced Increases in Cell Proliferation in p53- p21WAFl Regulates Anchorage-independent Growth of HCT116 Colon
Satoru Matsuda, Ryu Katsumata, Takahito Okuda, Tatsuyoshi Yamamoto, Kou deficient. Mice. Tokuo Sukata, Keisuke Ozaki, Satoshi Uwagawa, Takaki Carcinoma Cells via E-Cadherin Expression. Sebastian Mueller, Enrique
Miyazaki, Takeshi Senga, Kazuya Machida, Aye Aye Thant, Shigeka Seki, Hideki Wanibuchi, Shinji Yamamoto, Yasuyoshi Okuno, and Shoji Cadenas, and Axel H. Schénthal
Nakatsugawa, and Michinari Hamaguchi Fukushima.
Source of Oncofetal ED-B-containing Fibronectin: Implications of Produc-
18 LPorsesm alofi gnFraangti leL esHiiosntsi.d ineX inTgr iaPdei EHxaop,r esJsoisoenp h inE . CoWliollriesc,t alT hoCmaarsc inG.o maPsre tlaonwd, Endocrinology tMiaosn sibmyo BoPtighn atTelulim,o r Maarnyd AE. ndRoitttheerl, iaNli geCle llSs.. CoMuarrttae naMyi-dLuullcak,, Raankde shA ndVreerwm a,J
J. Sunil Rao, Gregory T.M acLennan, Ian C. Talbot, and Theresa P. Pretlow ylated-Neural Cell Adhesion Molecule Expression in Rat Pituitary T. George
22 IiWnniglc lriePaarmsoset,de inpT rSa3Ic-GedyFe BpPeJ-n. 3d eCnolitln a rAHdp,u ompatColnas iirseC oblMyo. n tihceP erIAknsds,eu lnioPnma-ulali- kdee NreGiwrvcoeowdmt bh, C eFlalMcsto. ograA nnaBnid nednC- mJLoaoaurnr neyni tn GWoDiuasvntieearlrn,- eFtTu,Jur atmchoq ureGselRn iaevntiest v)e TIRrsoo uuiRgloelanls,a, teandWd a tno DdoaGm rienwiRteqhnu aeu |d R,Fa itgea Praeaslcnladal -eB MraalCnhgieegvrna allniceyr., TvHeoildsvetaeokdsi t eirMnoi nyeaP-krreoe,gp rreCesosslsileoeden n PtNroe olsstAoannt,de r oPgaMueelsn s Sa. gIeRn-ed2ne npieeI,ns deaannn dc eA Mnatriitani pno PprtEo.o sttGialcte ea vGee Cnaen cerIn.-
Moorghen, Jeff M. P. Holly, and Chris Paraskeva E-Cadherin Promotes Intraepithelial Expansion of Bladder Carcinoma
28 Tumor Progression Is Accompanied by Significant Changes in the Levels of Experimental Therapeutics CVeelrlmse y,i n anR enién Vivtarn o dMeond elBe emofd ,C arWciinnaonmda Ni.n SMi.t u. DiEnrjiecn s,M . aJn.d BinTdheelosd, orMuasr ceHl.
Expression of Polyamine Metabolism Regulatory Genes and Clusterin (Sul- Re-Evaluating Gadolinium(If) Texaphyrin as a Radiosensitizing Agent. Van Der Kwast
fated Glycoprotein 2) in Human Prostate Cancer Specimens. Bettuzzi Eric J. Bernhard, James B. Mitchell, Dennis Deen, Monika Cardell, David I
Saverio, Davalli Pierpaola, Astancolle Serenella, Carani Cesare, Madeo Bruno, Rosenthal, and J.M artin Brown. Inflammatory Cytokines Induce DNA damage and Inhibit DNA repair in
Tampieri Auro, and Corti Amaldo. Cholangiocarcinoma Cells by a Nitric Oxide-dependent Mechanism.
Radiosensitivity of Thymidylate Synthase-deficient Human Tumor Cells Is Meeta Jaiswal, Nicholas F. LaRusso, Lawrence J. Burgart, and Gregory J
35 Threonine Phosphorylation of the MMACI/PTEN PDZ Binding Domain Affected by Progression through the G1 Restriction Point into S-Phase: Gores.
Both Inhibits and Stimulates PDZ Binding. Nils B. Adey, Liwen Huang, for Hwa-Shin Hwang,
Patricia A. Ormonde, Michelle L. Baumgard, Ralph Pero, Deepthi V Thomas W. Davis, ‘ie A "Houghton, and Timothy J. Kinsella.
Byreddy, Sean V. Tavtigian, and Paul L.B artel
191 Announcements
38 Carcinogenic Nickel Induces Genes Involved with Hypoxic Stress. Molecular Biology and Gensiics 2000 Annual Meeting
42 TAKJpoouhnomnsposttoraonn ,st iiSsnu a pnbpdy rS eaMaslansnx ii koIonnCw to,se taranf.de M rioSkneh-naisiinl d uciV.b ilteio nB lPatrogo otTesikunlm,oo nrnp y2,0 N2e,c rHioensa itBshr eeraF satc tRoyCraa nn,ca e-riR nadCnuedclalelsdl. AylMopuPcroCaasttLieas,s, CaoiM tl oCi entondT teurntamh loe rMo NPreeiSrtrioavn,uo mculTiseeut assu.Sy: A HkBiiiydnaemdwasa, k tiiof a inpN d5a 3k-Yabugisanuwdkaie,n gN KauPkormfao imtkAuedori na K2o yaanmda ,T raPYnoosjl-i- FWLuaottruAAekrsn-essnb ohurcaeoAilapnak ntiuinMooagennl e tPRifMaeonetsrghe e otaCbiraincnoghcls eo rgS yoef sR seitoshfoe en a CraAcantmh ce etrrhie c an
47 MFYiuoenmngi- tCrhWeiemeno ,r gHiuDnnug e Cn -HRwevae rsYeasn , MuBlitlli drSupgo hnR,e siJsiotnagn ceD einng ,C ellSsh iTarwa-nYsifhe ctLeidn , wiatnhd PSNaLalnAicGvyIa r,y S . tAhGgel taenMnd,as i,n W imITs : Ja. MP.o siVtainvion e de RTeaVgernug,le at taonidrn KPoolfe n /GKFa-sI I. MaArdiaennnoem a L. of Votzh,e WWoorrCRkkleisssnhehiaocorapplc h ooOnnn cMoMeolltoehgcoyud lsa r in BiColilnoigcya l inC ancer
tRhoes s, BrLe.a sAtu stCian ncDeory le,R esWiesitdaonnceg YParontge,i n.a nd SrLiedeh arM . K.G reReanbbienrdgrearn , Douglas D. CFMaraernqcauibenun ots YaorGscehoniemdtaai, c aZnhHdue teIXrtuose g eInnGefoilntugye, n ceiT no sohtnih eh aPrChule onnoMatalyt psiuEcmv ootlDoui,tv ieornYs iotsoyhf.i tGoHyminoreo caokHliao mgaiFnucojai.li ACaAlCReenRsd eaar Srpceohcf iaElv enCtosn ferences in Cancer
51 Enhancement of Tumor-specific Immune Response with Plasmid DNA Rep- Masaharu Fukunaga, Ralph H. Hruban, Edward Gabrielson, and Toshikazu
licon Vectors. Wolfgang W. Leitner, Han Ying, David A. Driver, Thomas W Shirai
Dubensky, and Nicholas P. Restifo. 194 Instructions for Authors
ICBP90, a Novel Human CCAAT Binding Protein, Involved in the Regula-
56 A Novel Form of Prostate-specific Antigen Transcript Produced by Alter- tion of Topoisomerase [la Expression. Raphaél Hopfner, Marc Mousli,
native Splicing. Tsutomu Tanaka, Takahiro Isono, Tatsuhiro Yoshiki, Takeshi Jean-Marc Jeltsch, Angélique Voulgaris, Yves Lutz, Cristi Marin, Jean-Pierre
Yuasa, and Yusaku Okada Bellocq, Pierre Oudet, and Christian Bronner 201 Author index
January 15, Number 2
Review Selective Loss of Estrogen Receptor 6 in Malignant Human Colon. 282 Protein Phosphorylation Is a Regulatory Mechanism for 0®-Alkylguanine-
Eugene F. Foley, Amir A. Jazaeri, Margaret A. Shupnik, Omid Jazaeri, and DNA Alkyltransferase in Human Brain Tumor Cells. Kalkunte S
203 Rtoergsu. latTainojna oVfe iAknkgoiloag,e neMsairsi kav ia KVaarskckauilnaern , EndLoetnhae liaCll aeGsrsoonw-tWhe lsFha,c tora ndR ecKeapr-i Laurel W. Rice SFrrainvceinsu goAplail-,O smSarni nivas R. S. Mullapudi, Jiang Shou, Tapas K. Hizra, and
Alitalo. yEpfofescitss ofC oClyocrleicnt alD 1 PCoalnycmeorr. phSihsomu mionn g Age Koofn gO,n set Chorfi sHteorpehderi taryI . NoAnmpoosl,- Regular Articles
Rajyalakshmi Luthra, Patrick M. Lynch, Bernard Levin, and Marsha |
Advances |i n Brief Frazier. Biochemistry
213 Malonyl-Coenzyme-A Is a Potential Mediator of Cytotoxicity Induced by Genetic Vaccination with “Self” Tyrosinase-related Protein 2 Causes Mel- 288 Nuclear Matrix Proteins Associated with DNA in Situ in Hormone-depen-
FnForaagtnrtcayif-stA sc.i J.d EClhlSreynen stt,hS .a sGePoi jzeeIrbn, hibJL.ia tgiaFonrn e hTyhiwnuo ptaH,r iu,m CarnaWi agn BrA.eF aasntTg o wCnHasanne,cn de,r M icCahenaldel ls FraaLn.n dci sP iXnenP-,. aRNinocbohemoralta os ERPro.a ndcRiaec,st aitfiPooa,on l aa ndb ZuatPm aboolnano it ,Z anVoWivtieilllllioeg.om. WV.i ncOevnezrow ijkB,r ontDee,b oraElhi sa R. ApSoulrlmoanni,, dVeinrtgi niaa ndA . SHpoenrcmeor,n e-Sihnandteip eKn. deSnamtu el,H uamnad nJ ameBsr eaRs. t DavCiaen cer Cell Lines.
Kuhajda Carcinogenesis
The HRASI Minisatellite Locus and Risk of Ovarian Cancer. Jeffrey N
Redox Regulation of Glutathione S-Transferase Induction by Benzyl Iso- Weitzel, Shaofeng Ding, Garry P. Larson, Rebecca A. Nelson, Annekathryn 293 Chemoprevention of Colon Cancer by Specific Cyclooxygenase-2 Inhibitor,
thiocyanate: Correlation of Enzyme Induction with the Formation of Reac- Goodman, Edward C. Grendys, Harrison G. Ball, and Theodore G. Krontiris Celecoxib, Administered during Different Stages of Carcinogenesis.
tive Oxygen Intermediates. Yoshimasa Nakamura, Hajime Ohigashi, Seiji Bandaru S. Reddy, Yoshinobu Hirose, Ronald Lubet, Vernon Steele, Gary
MTaossuhidhai,k o OAksiarwaa , MMuarsaakyaomsih,i ImYaagsuajwiar,o anMdo rKiomjiit suU,c hidaY oshiyuki Kawamoto. M{nehcihbaitnoirs m Gefnoers Iinn acGtaisvtartiico n Caonfc etrh e CeKlIlPs. FJaomnigl-yY eoCny clSihnin-,d epHeynudne-nSte okK inKaisme, Kelloff, Susan Paulson, Karen Seibert, and Chinthalapally V. Rao.
Jinseu Park, Jae-Bong Park, and Jae-Yong Lee Clinical Investigations
Evidence That the Epidermal Targets of Carcinogen Action Are Found in
ctlhees . InRteerbfeocllciac Jul.aMr o rrEipsi,d eKrimmibse rloyr ITnrfyusonnd,i baunldu m Kaia s Qw.e lWlu .a s in the Hair Folli- Prostate Mutations in Rats eee by b\tphyeri diSnue.s pecGtreedg oHruym an RC. arcinStougaertn, 298 ScMeecrpB:ra irdaTeth,i en ga ndFR aolvSeoa rmaubeollfe HEfe-rlColammd ahnUe nrfianv.o raRbulteh PrHoeginmoasntni,c MFaurskheernsg in LaBnr,e astR usCsaenl-l
James Holcroft, Johan | G de Boer, and Bay Ww Glickman.
Vascular Protection by Chloroquine during Brain Tumor Therapy with
Tf-CRM107. Naoshi Hagihara, Stuart Walbridge, Alan W. Olson, Edward H. Epidemiology and Prevention
Oldfield, and Richard J. Youle. The Angiogenic Factor Interleukin 8 Is Induced in Non-Small Cell Lung
Cancer/Pulmonary Fibroblast Cocultures. [an C. Anderson, Silvie E. Mari, 305 Association of Vitamin D Receptor Gene Polymorphism with Prostate Can-
RIentdhuac tiRo. n Neofw bUotledr inaen dA dJeonacohciamr cGi.n oLmiaeh r in CD-1 Mice by Catechol Estrogens. RyanJ . Broderick, Bernard P. Mari, and Margaret A. Shipp. cSehri gearnud SBaetTonahik,ge hni TrooPs rhoisyStaua ztuiAkcki a,o H,y pRyeNurospreliiha iskioSa a saTiksni u,ca h iJyLaaip,z ahnoNenasgoe t akWPeao npguS,lha itmioKodanaz.,u narTYioa msounhSoiatrkoio,
Tamoxifen Chemoprevention of a Hormone-independent Tumor in the Wada, Akio Koizumi, Junichi Chihara, Osamu Ogawa, and Tetsuro Kato.
Nickel Compounds Are Novel Inhibitors of Histone H4 Acetylation. Limor Proto-neu Transgenic Mice Model. Sylvie Ménard, Piera Aiello, Elda
Broday, Wu Peig, Min-Hao Kuo, Konstantin Salnikow, Maria Zoroddu, and Tagliabue, Cristiano Rumio, Pier Luigi Lollini, Maria I. Colnaghi, and Andrea
Max Costa. Balsari Experimental Therapeutics
309 = Anti-invasive, Anti igenic, and A ic Activoif tthie ePHsSC N
Prognostic Significance of Cyclin E Overexpression in Resected Non-Small Heregulin Induces Expression, DNA Binding Activity, and Transactivating Sequence in Prostate Carcinoma. Donna L. Livant, R. Kaye Brabec,
Cell Lung Cancer. Tatsuo Fukuse, Toshiki Hirata, Hironobu Naiki, Shigeki Functions of Basic Leucine Zipper Activating Transcription Factor 4. Kenneth J. Pienta, David L. Allen, Kotoku Kurachi, Sonja Markwart, and
Hitomi, and Hiromi Wada Amjad H. Talukder, Ratna Vadlamudi, Mahitosh Mandal, and Rakesh Kumar Ameet Upadhyaya.
Contents of Volume 60
January 1, Number 1
Editorial Identical Clonality of Sporadic Gastrinomas at Multiple Sites. Stephan | iated Inactivation of pl4*RF js Indepen-dent of
Goebel, Alexander O. Vortmeyer, Zhengping Zhuang, Jose Serrano, Robert T pi6!NKda My ethylation and p53 Mutational Status. Manel Esteller, Silvia
1 Cancer Research for the New Millennium. Frank J. Rauscher, III Jensen, and Irina A. Lubensky TBoarytloilna,, anMdi noJraum es ToGy.o taH,e rmGaanb riel Capella, Miguel Angel Peinado, Stephen B
N-Myc Induction Stimulated by Insulin-like Growth Factor I through Mi-
Advances in Brief ttoogmean -aCcetllisv.a teAdk ikPor otMeiisna waK,i naHsaej imSei gnHaolsioin.g PAkaitkhow ayA riimno toH, umTaank umNae urSohbiklaatsa.- Tumor Biology
Shinji Akioka, Takafumi Matsumura, Peter J. Houghton, and Tadashi Sawada. B1,6-N-Acetylglucosamine-bearing N-Glycans in Human Gliomas: Implica-
2 Therapy of Human Pancreatic Carcinoma Implants by Irinotecan and the tions for a Role in Regulating Invasivity. Hirotaka Yamamoto, Jason
Oral Immunomodulator JBT 3002 Is Associated with Enhanced Expression A Distinct Tumor Suppressor Gene Locus on Chromosome 15q21.1 in Swoger, Suzanne Greene, Tasuku Saito, Jay Hurh, Charla Sweeley, Jan
of Inducible Nitric Oxide Synthase in Tumor-infiltrating Macrophages. Sporadic Form of Colorectal Cancer. Won Sang Park, Jik Young Park, Ro Leestma, Edward Mkrdichian, Leonard Cerullo, Atsushi Nishikawa, Yoshito
Christiane J. Bruns, Hisashi Shinohara, Matthew T. Harbison, Darren W Ra Oh, Nam Jin Yoo, Sug Hyung Lee, Min Sun Shin, Hun Kyung Lee, Ihara, Naoyuki Taniguchi, and Joseph R. Moskal
Davis, Gina Nelkin, Jerald J. Killion, David J. McConkey, Zhongyun Dong. Seoyoung Han, Sungjoo Kim Yoon, Su Young Kim, Chan Choi, Pum Joon
and Isaiah J. Fidler. Kim, Seong Taek Oh, and Jung Young Lee c-Myc Suppresses the Tumorigenicity of Lung Cancer Cells and Down-
Regulates Vascular Endothelial Growth Factor Expression. Linda F. Barr
8 pMhuatraytnigoenas l inC atrhec iRneotmian.o blPaisert omPaa-olroe laCtleadud ioG,e neC anRdBa2c/ep /3M0. iHno wParridm,a ryY anN asFou-, Regular Articles SHuysuanns ukE. SChaimmp,b elaln,d CGhrie goV.r y DaBn.g Diette, Edward W. Gabrielson, Sunkyu Kim,
CCaaptuetrii,n a anCdi ntAi,n tonLiuoi giG ioCraldiafnaon o, Pietro Micheli, Edward W. Mercer, Mario tHhiegliha l LevOevlasr ioafn StCraonmcaelr . HyaMalaurrito nanA. PrAnetdtiilcat, PoRoarij a DisHe. aseT aOmmuit,c omMea rkink uE pi-[|
Carcinogenesis Tammi, Kari J.S yrjiinen, Seppo V. Saarikoski, and Veli-Matti Kosma
13. Molecular Cloning and Characterization of Human MAWD, a Novel Protein
Containing WD-40 Repeats Frequently Overexpressed in Breast Cancer. Org: ific, Carcinogen-induced Increases in Cell Proliferation in p53- p21WAFl Regulates Anchorage-independent Growth of HCT116 Colon
Satoru Matsuda, Ryu Katsumata, Takahito Okuda, Tatsuyoshi Yamamoto, Kou deficient. Mice. Tokuo Sukata, Keisuke Ozaki, Satoshi Uwagawa, Takaki Carcinoma Cells via E-Cadherin Expression. Sebastian Mueller, Enrique
Miyazaki, Takeshi Senga, Kazuya Machida, Aye Aye Thant, Shigeka Seki, Hideki Wanibuchi, Shinji Yamamoto, Yasuyoshi Okuno, and Shoji Cadenas, and Axel H. Schénthal
Nakatsugawa, and Michinari Hamaguchi Fukushima.
Source of Oncofetal ED-B-containing Fibronectin: Implications of Produc-
18 LPorsesm alofi gnFraangti leL esHiiosntsi.d ineX inTgr iaPdei EHxaop,r esJsoisoenp h inE . CoWliollriesc,t alT hoCmaarsc inG.o maPsre tlaonwd, Endocrinology tMiaosn sibmyo BoPtighn atTelulim,o r Maarnyd AE. ndRoitttheerl, iaNli geCle llSs.. CoMuarrttae naMyi-dLuullcak,, Raankde shA ndVreerwm a,J
J. Sunil Rao, Gregory T.M acLennan, Ian C. Talbot, and Theresa P. Pretlow ylated-Neural Cell Adhesion Molecule Expression in Rat Pituitary T. George
22 IiWnniglc lriePaarmsoset,de inpT rSa3Ic-GedyFe BpPeJ-n. 3d eCnolitln a rAHdp,u ompatColnas iirseC oblMyo. n tihceP erIAknsds,eu lnioPnma-ulali- kdee NreGiwrvcoeowdmt bh, C eFlalMcsto. ograA nnaBnid nednC- mJLoaoaurnr neyni tn GWoDiuasvntieearlrn,- eFtTu,Jur atmchoq ureGselRn iaevntiest v)e TIRrsoo uuiRgloelanls,a, teandWd a tno DdoaGm rienwiRteqhnu aeu |d R,Fa itgea Praeaslcnladal -eB MraalCnhgieegvrna allniceyr., TvHeoildsvetaeokdsi t eirMnoi nyeaP-krreoe,gp rreCesosslsileoeden n PtNroe olsstAoannt,de r oPgaMueelsn s Sa. gIeRn-ed2ne npieeI,ns deaannn dc eA Mnatriitani pno PprtEo.o sttGialcte ea vGee Cnaen cerIn.-
Moorghen, Jeff M. P. Holly, and Chris Paraskeva E-Cadherin Promotes Intraepithelial Expansion of Bladder Carcinoma
28 Tumor Progression Is Accompanied by Significant Changes in the Levels of Experimental Therapeutics CVeelrlmse y,i n anR enién Vivtarn o dMeond elBe emofd ,C arWciinnaonmda Ni.n SMi.t u. DiEnrjiecn s,M . aJn.d BinTdheelosd, orMuasr ceHl.
Expression of Polyamine Metabolism Regulatory Genes and Clusterin (Sul- Re-Evaluating Gadolinium(If) Texaphyrin as a Radiosensitizing Agent. Van Der Kwast
fated Glycoprotein 2) in Human Prostate Cancer Specimens. Bettuzzi Eric J. Bernhard, James B. Mitchell, Dennis Deen, Monika Cardell, David I
Saverio, Davalli Pierpaola, Astancolle Serenella, Carani Cesare, Madeo Bruno, Rosenthal, and J.M artin Brown. Inflammatory Cytokines Induce DNA damage and Inhibit DNA repair in
Tampieri Auro, and Corti Amaldo. Cholangiocarcinoma Cells by a Nitric Oxide-dependent Mechanism.
Radiosensitivity of Thymidylate Synthase-deficient Human Tumor Cells Is Meeta Jaiswal, Nicholas F. LaRusso, Lawrence J. Burgart, and Gregory J
35 Threonine Phosphorylation of the MMACI/PTEN PDZ Binding Domain Affected by Progression through the G1 Restriction Point into S-Phase: Gores.
Both Inhibits and Stimulates PDZ Binding. Nils B. Adey, Liwen Huang, for Hwa-Shin Hwang,
Patricia A. Ormonde, Michelle L. Baumgard, Ralph Pero, Deepthi V Thomas W. Davis, ‘ie A "Houghton, and Timothy J. Kinsella.
Byreddy, Sean V. Tavtigian, and Paul L.B artel
191 Announcements
38 Carcinogenic Nickel Induces Genes Involved with Hypoxic Stress. Molecular Biology and Gensiics 2000 Annual Meeting
42 TAKJpoouhnomnsposttoraonn ,st iiSsnu a pnbpdy rS eaMaslansnx ii koIonnCw to,se taranf.de M rioSkneh-naisiinl d uciV.b ilteio nB lPatrogo otTesikunlm,oo nrnp y2,0 N2e,c rHioensa itBshr eeraF satc tRoyCraa nn,ca e-riR nadCnuedclalelsdl. AylMopuPcroCaasttLieas,s, CaoiM tl oCi entondT teurntamh loe rMo NPreeiSrtrioavn,uo mculTiseeut assu.Sy: A HkBiiiydnaemdwasa, k tiiof a inpN d5a 3k-Yabugisanuwdkaie,n gN KauPkormfao imtkAuedori na K2o yaanmda ,T raPYnoosjl-i- FWLuaottruAAekrsn-essnb ohurcaeoAilapnak ntiuinMooagennl e tPRifMaeonetsrghe e otaCbiraincnoghcls eo rgS yoef sR seitoshfoe en a CraAcantmh ce etrrhie c an
47 MFYiuoenmngi- tCrhWeiemeno ,r gHiuDnnug e Cn -HRwevae rsYeasn , MuBlitlli drSupgo hnR,e siJsiotnagn ceD einng ,C ellSsh iTarwa-nYsifhe ctLeidn , wiatnhd PSNaLalnAicGvyIa r,y S . tAhGgel taenMnd,as i,n W imITs : Ja. MP.o siVtainvion e de RTeaVgernug,le at taonidrn KPoolfe n /GKFa-sI I. MaArdiaennnoem a L. of Votzh,e WWoorrCRkkleisssnhehiaocorapplc h ooOnnn cMoMeolltoehgcoyud lsa r in BiColilnoigcya l inC ancer
tRhoes s, BrLe.a sAtu stCian ncDeory le,R esWiesitdaonnceg YParontge,i n.a nd SrLiedeh arM . K.G reReanbbienrdgrearn , Douglas D. CFMaraernqcauibenun ots YaorGscehoniemdtaai, c aZnhHdue teIXrtuose g eInnGefoilntugye, n ceiT no sohtnih eh aPrChule onnoMatalyt psiuEcmv ootlDoui,tv ieornYs iotsoyhf.i tGoHyminoreo caokHliao mgaiFnucojai.li ACaAlCReenRsd eaar Srpceohcf iaElv enCtosn ferences in Cancer
51 Enhancement of Tumor-specific Immune Response with Plasmid DNA Rep- Masaharu Fukunaga, Ralph H. Hruban, Edward Gabrielson, and Toshikazu
licon Vectors. Wolfgang W. Leitner, Han Ying, David A. Driver, Thomas W Shirai
Dubensky, and Nicholas P. Restifo. 194 Instructions for Authors
ICBP90, a Novel Human CCAAT Binding Protein, Involved in the Regula-
56 A Novel Form of Prostate-specific Antigen Transcript Produced by Alter- tion of Topoisomerase [la Expression. Raphaél Hopfner, Marc Mousli,
native Splicing. Tsutomu Tanaka, Takahiro Isono, Tatsuhiro Yoshiki, Takeshi Jean-Marc Jeltsch, Angélique Voulgaris, Yves Lutz, Cristi Marin, Jean-Pierre
Yuasa, and Yusaku Okada Bellocq, Pierre Oudet, and Christian Bronner 201 Author index
January 15, Number 2
Review Selective Loss of Estrogen Receptor 6 in Malignant Human Colon. 282 Protein Phosphorylation Is a Regulatory Mechanism for 0®-Alkylguanine-
Eugene F. Foley, Amir A. Jazaeri, Margaret A. Shupnik, Omid Jazaeri, and DNA Alkyltransferase in Human Brain Tumor Cells. Kalkunte S
203 Rtoergsu. latTainojna oVfe iAknkgoiloag,e neMsairsi kav ia KVaarskckauilnaern , EndLoetnhae liaCll aeGsrsoonw-tWhe lsFha,c tora ndR ecKeapr-i Laurel W. Rice SFrrainvceinsu goAplail-,O smSarni nivas R. S. Mullapudi, Jiang Shou, Tapas K. Hizra, and
Alitalo. yEpfofescitss ofC oClyocrleicnt alD 1 PCoalnycmeorr. phSihsomu mionn g Age Koofn gO,n set Chorfi sHteorpehderi taryI . NoAnmpoosl,- Regular Articles
Rajyalakshmi Luthra, Patrick M. Lynch, Bernard Levin, and Marsha |
Advances |i n Brief Frazier. Biochemistry
213 Malonyl-Coenzyme-A Is a Potential Mediator of Cytotoxicity Induced by Genetic Vaccination with “Self” Tyrosinase-related Protein 2 Causes Mel- 288 Nuclear Matrix Proteins Associated with DNA in Situ in Hormone-depen-
FnForaagtnrtcayif-stA sc.i J.d EClhlSreynen stt,hS .a sGePoi jzeeIrbn, hibJL.ia tgiaFonrn e hTyhiwnuo ptaH,r iu,m CarnaWi agn BrA.eF aasntTg o wCnHasanne,cn de,r M icCahenaldel ls FraaLn.n dci sP iXnenP-,. aRNinocbohemoralta os ERPro.a ndcRiaec,st aitfiPooa,on l aa ndb ZuatPm aboolnano it ,Z anVoWivtieilllllioeg.om. WV.i ncOevnezrow ijkB,r ontDee,b oraElhi sa R. ApSoulrlmoanni,, dVeinrtgi niaa ndA . SHpoenrcmeor,n e-Sihnandteip eKn. deSnamtu el,H uamnad nJ ameBsr eaRs. t DavCiaen cer Cell Lines.
Kuhajda Carcinogenesis
The HRASI Minisatellite Locus and Risk of Ovarian Cancer. Jeffrey N
Redox Regulation of Glutathione S-Transferase Induction by Benzyl Iso- Weitzel, Shaofeng Ding, Garry P. Larson, Rebecca A. Nelson, Annekathryn 293 Chemoprevention of Colon Cancer by Specific Cyclooxygenase-2 Inhibitor,
thiocyanate: Correlation of Enzyme Induction with the Formation of Reac- Goodman, Edward C. Grendys, Harrison G. Ball, and Theodore G. Krontiris Celecoxib, Administered during Different Stages of Carcinogenesis.
tive Oxygen Intermediates. Yoshimasa Nakamura, Hajime Ohigashi, Seiji Bandaru S. Reddy, Yoshinobu Hirose, Ronald Lubet, Vernon Steele, Gary
MTaossuhidhai,k o OAksiarwaa , MMuarsaakyaomsih,i ImYaagsuajwiar,o anMdo rKiomjiit suU,c hidaY oshiyuki Kawamoto. M{nehcihbaitnoirs m Gefnoers Iinn acGtaisvtartiico n Caonfc etrh e CeKlIlPs. FJaomnigl-yY eoCny clSihnin-,d epHeynudne-nSte okK inKaisme, Kelloff, Susan Paulson, Karen Seibert, and Chinthalapally V. Rao.
Jinseu Park, Jae-Bong Park, and Jae-Yong Lee Clinical Investigations
Evidence That the Epidermal Targets of Carcinogen Action Are Found in
ctlhees . InRteerbfeocllciac Jul.aMr o rrEipsi,d eKrimmibse rloyr ITnrfyusonnd,i baunldu m Kaia s Qw.e lWlu .a s in the Hair Folli- Prostate Mutations in Rats eee by b\tphyeri diSnue.s pecGtreedg oHruym an RC. arcinStougaertn, 298 ScMeecrpB:ra irdaTeth,i en ga ndFR aolvSeoa rmaubeollfe HEfe-rlColammd ahnUe nrfianv.o raRbulteh PrHoeginmoasntni,c MFaurskheernsg in LaBnr,e astR usCsaenl-l
James Holcroft, Johan | G de Boer, and Bay Ww Glickman.
Vascular Protection by Chloroquine during Brain Tumor Therapy with
Tf-CRM107. Naoshi Hagihara, Stuart Walbridge, Alan W. Olson, Edward H. Epidemiology and Prevention
Oldfield, and Richard J. Youle. The Angiogenic Factor Interleukin 8 Is Induced in Non-Small Cell Lung
Cancer/Pulmonary Fibroblast Cocultures. [an C. Anderson, Silvie E. Mari, 305 Association of Vitamin D Receptor Gene Polymorphism with Prostate Can-
RIentdhuac tiRo. n Neofw bUotledr inaen dA dJeonacohciamr cGi.n oLmiaeh r in CD-1 Mice by Catechol Estrogens. RyanJ . Broderick, Bernard P. Mari, and Margaret A. Shipp. cSehri gearnud SBaetTonahik,ge hni TrooPs rhoisyStaua ztuiAkcki a,o H,y pRyeNurospreliiha iskioSa a saTiksni u,ca h iJyLaaip,z ahnoNenasgoe t akWPeao npguS,lha itmioKodanaz.,u narTYioa msounhSoiatrkoio,
Tamoxifen Chemoprevention of a Hormone-independent Tumor in the Wada, Akio Koizumi, Junichi Chihara, Osamu Ogawa, and Tetsuro Kato.
Nickel Compounds Are Novel Inhibitors of Histone H4 Acetylation. Limor Proto-neu Transgenic Mice Model. Sylvie Ménard, Piera Aiello, Elda
Broday, Wu Peig, Min-Hao Kuo, Konstantin Salnikow, Maria Zoroddu, and Tagliabue, Cristiano Rumio, Pier Luigi Lollini, Maria I. Colnaghi, and Andrea
Max Costa. Balsari Experimental Therapeutics
309 = Anti-invasive, Anti igenic, and A ic Activoif tthie ePHsSC N
Prognostic Significance of Cyclin E Overexpression in Resected Non-Small Heregulin Induces Expression, DNA Binding Activity, and Transactivating Sequence in Prostate Carcinoma. Donna L. Livant, R. Kaye Brabec,
Cell Lung Cancer. Tatsuo Fukuse, Toshiki Hirata, Hironobu Naiki, Shigeki Functions of Basic Leucine Zipper Activating Transcription Factor 4. Kenneth J. Pienta, David L. Allen, Kotoku Kurachi, Sonja Markwart, and
Hitomi, and Hiromi Wada Amjad H. Talukder, Ratna Vadlamudi, Mahitosh Mandal, and Rakesh Kumar Ameet Upadhyaya.
CONTENTS OF VOLUME 60
Radiation-induced Apoptosis of Endothelial Cells in the Murine Central Genetic Alterations Disrupting the Nuclear Localization of the Retinoblas- Thrombospondin-! Promotes «381 Integrin-mediated Adhesion and Neu-
Nervous System: Protection by Fibroblast Growth Factor and Sphingomy- toma-related Gene RB2/p130 in Human Tumor Cell Lines and Primary rite-like Outgrowth and Inhibits Proliferation of Small Cell Lung Carci-
elinase Deficiency. Louis A. Peiia, Zvi Fuks, and Richard N. Kolesnick Tumors. Caterina Cinti, Pier Paolo Claudio, Candace M. Howard, Luca noma Cells. Neng-hua Guo, Nancy Smyth Templeton, Hebah Al-Bara.
Maria Neri, Yan Fu, Lorenzo Leoncini, Gian Marco Tosi, Nadir Mario JoAnne Cashel, John M. Sipes, Henry C. Krutzsch, and Da t
Differential Toxicities of Anticancer Agents among DNA Repair and Check- Maraldi, and Antonio Giordanc A Specific Sequence of the Noncollagenous Domain of the a(IV) Chain of
pSJ.oz iaRnnotkb aesritM,s, u tDaiEn ltiKs.z abNoegfut yhe LSna,. c JcehCnaasternho,em ryiLcneeel sa nd LcudeHlr.o ewv, HiasritHaweee.al tlh,eJ url ainaMnd. SDtA.ue npshteSanin m,o Hn., C hFrriiPsehtniodlp ihpepre Iinngd ucTeedst RMfoiotcrh rfuobCn,au rcriiPeeeurtsrsa FoSrfc heiqitau ze,Bn RcCiSAey/slJv i ain MuPteraBitocpihhoumen,r ali Tna LnjByarm epaVhsootl cmy. teCsEaln kceea rs EaFb aeSmrcihraleriedents- tBTeeyliplnoeans ,e IsV FbCryoa lnlgTaougisem-noX ra IvniheCierbl iltss.M aqESuyxalprvrti,ee ssiPaoscnJoa, c quaens dJ inPgA ctiHBavno,a .trei l,o nP hiNloiifcp hpMoela atsr Giilxle ryA,.a Keefal G eorges
berg, Walther Vogel, and Giinter Speit and Jean Claude Monbor
PVPJerracomoetsssott.raa .tt ee -JsapCmeaceniscf eircP:. FCA. onntsiLtgaretuhnac mt,i PornP e tearn dF . TSeEesanrthliean,ng ceVorifv iae nD rTiiMvsaseuunte n-esrpG,ee cniefa incd ThNAeidcrehanopolyav si rufoDs.r mAAonTltMoh ognoyDu esf iJ.c RieecncoWyym nbsihCnaawau-tsBieorosi ns ,a ni n IanMndic creRe.oa bseerdAt l eFxHra. nedqSeucrhe inecsJyt. ! R. ofB iisnhotpr, achrCoarmroolseoe maBla rloHwo - HKTeuurmmeaogrru linC ellRse. gulAamtjiaodn Ho. f TAaultukodcerri, ne LiMaontai litAyd am.F actoArv rahE xpresRsazi, on a in Human
Processing of Cyclin E Differs between Normal and Tumor Breast Cells.
STchaet tGere ldFaancatmoyrc-iMnest -UArroek iPnoatsenet PInlhaisbmiitonrosg eonf thAec tHievpaattoorc-yPtlea smGirno wtPhro teFoalcyttoirc/ iLAen id DuocXimeadio naMnaontdr phWRooellneoh guiafco r LtaThnrega ncs-fJournm atNiHo2n- Teorfm iHnuamla nK inLausneg inC aOrncciongoemnai c CeRlalss-. RKiecyhoamradr stM . Harwell, Donald C. Porter, Christopher Danes, and Khanda
Network. Craig P. Webb, Curtis D. Hose, Shahriar Koochekpour, Michael Oncogenes and Tumor Angiogenesis: Differential Modes of Vascular r.nto-
Jeffers, Marianne Oskarsson, Edward Sausville, Anne Monks, and George F Inherited Predisposition to Pancreatic Adenocarcinoma: Role of Family History thelial Growth Factor Up-Regulation in ras-transformed Epithelial Cells
Vande Woude and Germ-Line p/6, BRCAI, and BRCA2 Mutations. Geeta Lal, Geoffrey and Fibroblasts. Janusz Rak, Yoshihiro M f
Liu, Beverley Schmocker, Pardeep Kaurah, Hilmi Ozcelik, Steven A. Narod Tamir, Alicia Viloria-Petit, Jorge
Effective Elimination of Lung Metastases Induced by Tumor Cells Treated Mark Redston, and Steven Gallinger and Ri
with Hydrostatic Pressure and N-Acetyl-i-Cysteine. Yechiel Goldman.
Alpha Peled, and Meir Shinitzky Deregulation of the p144RFqpM2/ps3 Pathway Is a Prerequisite for
Human Astrocytic Gliomas with G1-S Transition Control Gene Abnormal-
ities. Koichi Ichimura, Maria Bondesson Bolin, He a M. Goike, Esther E
Immunology Schmidt, Ahmad Moshref, and V. Peter Collins CAonrdrreosgpeonn deRneccee ptorer: GJe. neL:. SMtoalnefcourlda r et Maalr,k eProsl ymoof rpPhriosct ateR ecepCtaoncre r inR istkh.e
Ability of Systemic Interleukin-12 to Hamper Progressive Stages of Mam- ZK7, a Novel Zinc Finger Gene, Is Induced by Vascular Endothelial Growth Cancer Res., 57: 1194-1198, 1997. Takal
mary Carcinogenesis in HER2/neu Transgenic Mice. Katia Boggio, Emma Factor and Inhibits Apoptotic Death in Hematopoietic Cells. Ken
Di Carlo, Stefania Rovero, Federica Cavallo, Elena Quaglino, Pier Luigi Kuramoto, Toshihiro Uesaka, Akiro Kimura, Masao Kobayashi, Hiromitsu
GLoulilidnoi , FoPranit.r izia Nanni, Giordano Nicoletti, Stanley Wolf, Piero Musiani, and Watanabe, and Osamu Katoh Announcements
The Cancer-free Phenotype in Trichothiodystrophy Is Unrelated to Its 2000 Annual Meeting
UErse7ec oPgoenfpi tzFiildnuego roCEgonemdnpoilgcee xneHoisus st otcoH omuIpmsaoatlniatb ei lPiaRtpayir le lLoeHmuaukvmoiacrynuts e CAyAntntoittgioegxniescn. -ATS*-a0rLa2yh0m 1p/hJ.H oPcYVyou tdee-1 6 RE.A erlpetaLtio, wre ,a Dnedf EelcAatli.an ne MRa.M r. kL eThBameylraonnre,nb urgM,i chaPeelt er H.H . L.C liGnrgeeenn,, SJuesaann KrA.u tmHaarncno,u rt,C olJiilnli Fan Future Annual Meetings of the American
P. Rod Dunbar, Eve M. L. Evans, Alison N. Fiander, Leszek K. Borysiewicz. Workshop on Pathobiology of Canc
Vincenzo Cerundolo, and Stephen Man Tumor Biology Workshop on Molecular Biology
Clinical Oncology
aTMrnuadtn astfSieuorpn.ps r eMPsiiosne ril otehnPe ac ouolRfoel tTaiCunlramou bodlriaoB ,si tGoormCloaawon-tdrghaeycl ea tinea Mdn. V idvGHo eo nwGeba yre dRn,RB ee2tt/Crpaior1vcm3ie0srn u si-nPm aecLiduliinoa,gt edTC autmeGoreirnnsea IEWAAepnl ritvdPteeeherolepallltc,ai itraid loea n Mn doM CrweipilLmtlhaishro:rc g y eEnnoRdeTfeaos igtitEu hs-leS aletilaiaenolcdn t iCnHe lbylypLs ei rgpIEaslsn atdars oiPgaIre nenhr.oie fbq iutMPisars leianStteiehao ylp ylf!oa rs PtL iBecwr iasnH cuhXSimh-naedgkneh apreD,uBn crdteeaanlJsit-tl l CWAaAolCrReRR knee dssaeeraa orrSn ccphhMeo ecf tiEhavoled ns Cionnf ereCnlcien ical Cancer
Cinti, Gaetano Romano, Corrado Minimo, Nadir M. Maraldi, John D. Minna, Lung Colonization of Tumor Cells. Michiko N. Fukuda, Chikara Ohyama.
Larry Gelbert, Lorenzo Leoncini, Gianmarco Tosi, Pietro Micheli, Mario Kevin Lowitz, Osamu Matsuo, Renata Pasqualim, Erkki Ruoslahti, and
Caputi, Giovan Giacomo Giordano, and Antonio Giordano. Minoru Fukuda Author index
February 1, Number 3
Advances iirn Brief Regular Articles Expression of Endogenously Activated Secreted or Cell Surface Car-
boxypeptidase A Sensitizes Tumor Cells to Methotrexate-a-Peptide Pro-
drugs. Daniel A. Hamstra, Michel Pagé, Jonathan Maybaum, and Alnawaz
CIandnuccetri onC elolfs Apboyp tao tSiact urCaeltle dD eaBtrha ncanhde d-inC hVaiivno GFraotwtty h AcIindh,i bi1t3i-oMne tohfy lHtuetmraan- Biochemistry Rehemtulla
dHeucaanngo ica nd AcJiida.n piZnhge nZhhuean gY ang, Shangpei Liu, Xudong Chen, Hang Chen, Mei gAant esI ndCoellol carCbyaczloe le ArIrnehsitb itCora usoefd Hubmya n DNCAh eckDpaomiangte . KinJaefsfer ey (ChR.k 1)J acAkbsroon- TThuamto r-Gteanregreatteisn g OCxyhgeemno-tfhreerea pyR adbiyc aal s Xanint hiTneu moOrx idTaissseu-e.P olymTeormo hiro ConjSuagwaate
Aidan Gilmartin, Christina Imburgia, James D. Winkler, Lisa A. Marshall, and Jun Wu, Takaaki Akaike, and Hiroshi Maeda.
Expression of a Highly Conserved Protein, p27BBP_ during the Progression Amy Roshak
of Human Colorectal Cancer. Francesca Sanvito, Federica Vivoli, Stefania Functional Interactions between Bile Acids, All-Trans Retinoic Acid, and
Gambini, Graziella Santambrogio, Marco Catena, Edi Viale, Fabrizio Veglia. Quantitative Analysis of Interindividual Variation of Glutathione S-Trans- 1,25-Dihydroxy-Vitamin D3 on Monocytic Differentiation and Myeloblastin
Alessandra Donadini, Stefano Biffo, and Pier Carlo Marchisio. ferase Expression in Human Pancreas and the Ambiguity of Correlating Gene Down-Regulation in HL60 and THP-1 Human Leukemia Cells.
Genotype with Phenotype. Brian F. Coles, Kristin E. Anderson, Daniel R Amazia Zimber, Annick Chedeville, Jean-Pierre Abita, Veronique Barbu, and
p53-dependent Global Genomic Repair of Benzo[a]pyrene-7,8-diol-9,10-ep- Doerge, Mona I.C hurchwell, Nicholas P. Lang, and Fred F. Kadlubar Christian Gespach.
oxide Adducts in Human Cells. Danie! R. Lloyd and Philip C. Hanawalt Carcinogenesis p21WAFUCIP! 4 ntisense Therapy Radiosensitizes Human Colon Cancer
Differentiation of Rat Oval Cells after Activation of Peroxisome Proliferator- by Converting Growth Arrest to Apoptosis. Hui Tian, Ellen K. Wittmack
High Frequency of K-ras Mutations in Biliary Duct Carcinomas of Cases activated Receptor a4. Catherine Kaplanski, Cindy J. Pauley, Thomas G and Timothy J. Jorgensen
with a Long Common Channel in the Papilla of Vater. Eiji Hidaka, Akio Griffiths, Thomas T. Kawabata, and Brian J. Ledwith
Yanagisawa, Makoto Seki, Kouichi Takano, Toshiaki Setoguchi, and Yo Kato. Immunology
OiPnhxgoy tgooefnnr aitnFi louenPn hcoietn oHdRayutnmeaa.m ni Bca BrabsTaarhlae rCaWep.ly l HCeCanardnce irnsSooinmg,an isf iTchdaeunrrteilsyna g MDT.er pelaBetutmsece hn,to r, LuPDrreiepnseee nrdvA-e STES.iux nmpgJorillreel si-sgSJiieatonmenee ss iiMsne .ta hy[Rlgeaoprto iroPt.ne rP owGgiretihnbienn y C,o tnhsMeta rruptc5at 3: PoPPgrorsoisbminobatl,e er iJnu dRiVetighv ioo KnR. elCRehevrdaiunsctcmeeas n ,d uGreiannnegd IpBllnaatnnektreelndes tuekibinun.t- 7/nBot7 .1N-oenntcroadninsgp lantAedde novTiurmuosress. GIenrdaulcde WiRleljiemcstkiyo n anodf TThroamna:s -
VaAnandut ghhAoalnlnya, n S.NR .o rDeOeseeen,r ofMPf.i chFerlawel eyT,. CDoeobprera, BaDbaivcihd, TAa. raB elAl.n ieSr,o sa,W ilJloisaemp h R.D . GZroelcloo., TaEfxrthaeinrbs igtTe unimRcoe rd uMciPecrdeo moPOtavipeoirnle.lx opmrPaee tsesrBi unrgJd. eRnPe drdoibtgue,ti n ENnaKhniacnyna scee Ed. CDeCr aerciknc sicnThhomemiidart , FEopJriumdnae trZimooiuns, TrLieaus,rt greiEtclitienzdga beotMfhu rHiuAn. mea Penra Tl-tCap,eS l3l- JoovsReherucaee xpptDr.o ers Ls iEEnlxglp ernehTosrusnme,od r ainCnd e lJlDsuo rnk bayt J. anD iT aHmCLoenAldl s.. A*X0i2p0i1n-g
Differences in Estrogen Receptor a Variant Messenger RNAs between Sarah E.B ourguignon, Terry D. Oberley, and Ajit K. Verma Molecular Biology & Genetics
Normal Human Breast Tissue and Primary Breast Carcinomas. Mariska Cell Proli jon Induced by Triiod in Rat Liver Is Associated Frequent Methylation of Estrogen Receptor in Prostate Cancer: Correlation
A. J. van Dijk, Augustinus A. M. Hart, and Laura J. van't Veer. with Nodule Regression and Reduction of Hepatocellular Carcinomas. with Tumor Progression. Long-Cheng Li, Richard Chui, Koichi Nakajima.
Giovanna M. Ledda-Columbano, Andrea Perra, Roberto Loi, Hisashi Bong Ryoul Oh, Harry C. Au, and Rajvir Dahiya
High-Activity Microsomal Epoxide Hydrolase Genotypes and the Risk of Shinozuka, and Amedeo Columbano.
Oral, Pharvnx, and Larynx Cancers. Nadejda Jourenkova-Mironova, Katja Clinical Investigations Detection of Plasma Tumor DNA in Head and Neck Squamous Cell i.a rci-
Mitrunen, Christine Bouchardy, Pierre Dayer, Simone Benhamou, and Ari noma by Microsatellite Typing and p53 Mutation Analysis.
Hirvonen. Telomerase Activity and Telomere Length in Acute and Chronic Leukemia, Coulet. Helene Blons, Arnauld Cabelguenne, Thierry Lecomte, Ol
Pre- and Post-ex Vivo Culture. Monika Engelhardt, Karen Mackenzie, Laccourreye, Daniel Brasnu, Philippe Beaune, Jessica Zucman
Pamela Drullinsky, Richard T. Silver, and Malcolm A. S. Moore. Laurent-Puig
Methylation of the Human Telomerase Gene CpG Island. Scott K
Dessain, Hua-yin Yu, Roger R. Reddel, Roderick L. Beijersbergen, and Robert Altered Hepatic Gluconeogenesis during 1-Alanine Infusion in Weight-los- Tumor Biology
CmA.oe ndsiWteaiittneubdte irvgGe. 2-AcMt ivAartrieosnt . ofM iCsyocolinn PBalr-k,a ssHoeceia-tDeodn cCdhca2e , KiJneaasneh o OvYeurnr,i deMso onp5s3u- aSiWnnpidgel clLtePumrie ontsegOrc . o CpCavy. an nc Deardage nnnde Pl aiBteeiT regun,rt ns oPavausel r O Eb.s eMSreivjaeesndus, r ebmJy.e nHP.t hso.Psa pulh SourWsuialsns noenM ,a gnMLeaettitjih-ciH jaslR fewOseuordnkk,ae rnkc.e J INnMnoietunuesgrg orbiCLnliesua,r satmaLoiyemdBoaen3 .i da anAndSn.d a tTM eahteyeEiBlrrids tr seIai,nc Ahhri-ebEK ipwtsaiEtoxnenipg nr ,eI ssS sikeAH dsi sKrioomcyb,iuy ak tie EMdon ndSihowiqtimuthaheed la,iIF un. mcr SSetuiansossaf,en d HRiGoEgrbnhoed-sroRhte gines.(k-
Jung, Yeon-Soo Kim, Sung-Ho Kim, Moon Hi Han, and Deug Y. Shin. Imaging Brain Tumor Proliferative Activity with (!24t}lododeoxyuridine. Seeger, and Donald L. Durden
Ronald G. Blasberg, Ulrich Roelcke, Regin Weinreich, Bradley Beattie, Klaus
No Evidence of Peutz-Jeghers Syndrome Gene LKB Involvement in Left- von Ammon, Yasuhiro Yonekawa, Hans Landolt, Honka Guenther, Nigel E Aminopeptidase N Is a Receptor for Tumor-homing Peptides and a Target
sided Colorectal Carcinomas. Virpi Launonen, Egle Avizienyte, Anu A. Crompton, Peter Vontobel, John Missimer, Ralph P. Maguire, Jacek for Inhibiting Angicyenesis. Renata Pasqualini, Erkki Kotvunen, Renate
Loukola, Paivi Laiho, Reijo Salovaara, Heikki Jarvinen, Jukka-Pekka Mecklin, Koziorowski, E.J oachim Knust, Ronald D. Finn, and Klaus L. Leenders Kain, Johanna Lahdenranta, Michiie Sakamoto, Anette Stryhn. Richard A
Asuka Oku, Miyuki Shimane, Hee C. Kim, Jin C. Kim, Jun-ichi Nezu, and Ashmun, Linda H. Shapiro, Wadih Arap, and Erkki Ruoslahti
Lauri A. Aaltonen. The Urokinase System of Plasminogen Activation and Prognosis in 2780 Breast
Cancer Patients. John A. Foekens, Harry A. Peters, Maxime P. Look, Henk Selective Expression and Constitutive Phosphorylation of SHC Proteins in
JGPFerAeteKnedr2oe mriiMkiécenl ieCrvD,o n3 0Mi*Bco nhiaHne,lo dgGPIkufninrchneliu ulndddCi esnlcglMh seu.ch Ah, t SeterLfsoahri nee inmzJe oroion ,sT, r iioMMmfaap renttrfh,ire ne da TnBdye rKnoitPszpe,ipt neererP ,e LtKieiSrcin hbtayeMsirael r ey GneOehnnle, aPMnoadrr tieoJnnagn e nEG,.. MMMe.aEi njpfeKlrrii-ejvdnd.a ne SmcGhiemliodtetrl,, ogMSioycnjh aa eal Cn.dD H. e nzKPrearnm-eeLrv,o egmnaNtnilsis, o nBrW iiinmn er,L . FJ.r itvza n JaPnuitctkeen., CtPMhaaiegor llmioeCa lcDocD3i ao4l,lC+ ’a rlAGogFa-lrSbiatrocei.tlel ilaalon,and PPoiSafeao rml Cmoha GrrieoLulunslnieigcp,h pi,e M yBPReaeolrlbbioecagcrreita no ouSsAal vboelrLtdeionu,i k, emiSAainlstv.oan niao AnPtionTaenbliilloii,o , BEonnnaPiticiea r
Substantially Reduced Risk of Cancer of the Aerodigestive Tract in Subjects roblast Growth Factor Confers a Less Malignant Phenotype in
Regulation of Tumor Necrosis soccer Apoptosis-inducing Ligand with Variant —463A of the Myeloperoxidase Gene. Ingolf Cascorbi, Stefan MDA-MB-231 Human Breast Cancer Cells. Reys M. Korah, Vilayvanh
Sensitivity in Primary and Transformed Human Keratinocytes. Martin Henning, Jiirgen Brockmiller, Jiirgen Gephart, Christian Meisel, Joachim M. Sysounthone, Yosef Golowa, and Robert Wieder.
Leverkus, Manfred Neumann, Thilo Mengling, Charles T. Rauch, Eva-Bettina Miiller, Robert Loddenkemper, and Ivar Roots.
Brécker, Peter H. Krammer, and Henning Walczak Experimental Therapeutics CAanndcreorg en MoDdeeplr ivaStyisotne mo f tIhned uPcreos horNmeounreo enCdooncvreirntea se-D3i1f0f ereHnutmiaatni on.P rosJtoahtaen
Down-Regulation of HER2/neu Expression Induces Apoptosis in Human Manumycin Enhances the Cytotoxic Effect of Paclitaxel on Anaplastic Thy- Jongsma, Monique H. Oomen, Marinus A. Noordzij, Wytske M. Van
Cancer Cells That Overexpress HER2/neu. Haeri Roh, James Pippin, and roid Carcinoma Cells. Sai-Ching Jim Yeung, Guangpu Xu, Jingxuan Pan, Weerden, Gerard J. M. Martens, Theodorus H. van der Kwast, Fritz H
Jeffrey A. Drebin Michelle Christgen, and Alexander Bamiagis. Schroder, and Gert J. van Steenbrug:
il
CONTENTS OF VOLUME
Drg-I as a Differentiation-related, Putative Metastatic Suppressor Gene in Letters to the Editor
Human Colon Cancer. Rong J. Guan, Heide L. Ford, Yineng Fu, Youzhi Li Announcements
Leslie M. Shaw, and Arthur B. Parde 766 Correspondence re: S. Shintani ef al., Intragenic Mutation Analysis of the 2000 Annual Meeting
Human Epidermal Growth Factor Receptor (EGFR ) Gene in Malignant Future Annual Meetings of the American
Human Oral Keratinocytes. Cancer Res., 59: 4142-4147, 1999. Jill | Association for Cancer Research
Reiter, Greg Eley, C. David james, and Nita J. Maihle. Reply by David Late-breaking Research Session at the
A Precursor Form of Prostate-specific Antigen Is More Highly Elevated in Wong Annual Meeting
Prostate Cancer Compared with Benign Transition Zone Prostate Tissue. Workshop on Pathobiology of Cancer
Stephen D. Mikolajezyk, Lisa S. Millar, Tang J. Wang, Harry G. Rittenhouse. Workshop on Molecular Biology in
Leonard S. Marks, Weitao Song, Thomas M. Wheeler, and Kevin M. Slawin. Clinical Oncology
Work on Methods in Clinical Cancer
Research
AACR Special Conferences in Cancer
Down-Regulation of the Insulin-like Growth Factor I Receptor by Antisense Meeting Report Research
RNA Can Reverse the Transformed Phenotype of Human Cervical Cancer Calendar of Events
Cell Lines. Keiichiro Nakamura, Atsushi Hongo, Junichi Kodama, Yasunari 768 Eleventh Annual Pezcoller Symposium: Molecular Horizons in Cancer
Miyagi, Mitsuo Yoshinouchi, and Takafumi Kudo Therapeutics. Enrico Mihich and David Livingston Author Index
February 15, Number 4
Advances in Brief Candidate Genes for the Hypoxic Tumor Phenotype. Albert C. Koong Inhibition of Human Prostate Cancer Proliferation in Vitro and in a Mouse
Nicholas C. Denko, Karen M. Hudson, Cornelia Schindler, Lillian Swiersz Model by a Compound Synthesized to Block Ca** Entry. Doris M
NKautdtaen , Micaneid.o l NSaAannrcaaylh ogLEu.. e,WB eluiEtgtBe,1l 0 8Ta9r,a ICn.hi Pboiletks, thLea MGornoiwctah V.o f SLteNwCaratP, MTiuchmaoerls Wi n CaEnaMdm MerPAmoatRon I NK oJc.h(, GC iDa1cS4cy7id)an, e y anE vaInsn,d uceHran i ofI bMraahtirmi,x QMueytnahl lopT.r oLtee, inDasaev idSJ yn.t hTeesririss, OHLaiNvnYeerXss -ti0ac1kn,d5 PTWriofirfmakansyr y SN.y nCeuHrlegtaiudsyrt,ei sc alTlFiyrm eosthwhliyty h LMC.ahMd eaemc odotnfharelordma, pyL aunndig n LLlCuoanyndgc eSCr.a nGcPreaatyri enCtesl.l
Osteoprotegerin Prevents and Reverses Hypercatcemia in a Murine Model GAulos,o RBoinndgss onIgn teLris, t StanleyC olZluacgkeern,a sea nd to Brtyhaen TP.u moToroi e. Cell Surface. Huiming Liang You, Cheng-Ta Yang, and David M. Jablons
Hypercalcemia of Malignancy. Casey Capparelli, Paul J
KVaons,t enuSihke,i la SSecaulnl y, MoMreoinyy,i ng CQhia,r liDea viSdta rLne.s,L aceyB, ernaandde ttCeo linW eiR.m aDnunn,s tanG wyneth GCHeaonnmeaci errPa r omPNaoattwiereront zs-.HD aynpMieosrnhmt,se etrhryGaleta ortgieSo ann cHh.i en zY-oCoTe,u smpoerWdsea sya,nn ed SMKaeonrcehu,lm oJEfis nt HeleJleeanrd,, aJnaLdmi esN eWcuGk SEAaxpapod,op stouDsraiems.i r IHangdAizutic mtoivAo,sn h usJhou,fd itHh LuemRoaandn n ayA., M yReDolozovei nds ZziapjLonre,iu ,k eamMniidc ch aUlri C elRBlolsas sesn,bs yc hMeUiirlnat raBsaorudna.d
Adenoviral Bak Overexpression Mediates Caspase-dependent Tumor Kill- Herman, and David Sidransky
iK.n g.H unAt,b ujiTainmgo thPya taerJ., McDBoinngnleilaln,g JFaacnkg , A. RoRboethr,t aYnud, SStheupnshuekneG . KSaw isher p53 Phosphorylation and Association with Murine Double Minute 2, c-Jun Immunology
NH}2-Terminal Kinase, p14’ Rl , and p300/CBP during the Cell Cycle and APRIL/TRDL-1, a Tumor Necrosis Factor-like Ligand, Stimulates Cell
A New Variant Anaplastic Lymphoma Kinase (ALK)-Fusion Protein after Exposure to Ultraviolet Irradiation. Thomas Buschmann, Victor Death. Kimberly Kelly, Elizabeth Manos, Gregory Jensen, Lincoln Nadauld.
(ATIC-ALK) in a Case of ALK-positive Anaplastic Large Cell Lymphoma. Adler, Ekaterina Matusevich, Serge Y. Fuchs, and Ze’ev Ronai and David A, Jones
Mirella Trinei, Luisa Lanfrancone, Elias Campo, Karen Pulford, David Y
Mason, Pier-Giuseppe Pelicci, and Brunangelo Falini 1028 Induction of Tumor Immunity and Cytotoxic T Lymphocyte Responses
Regular Articles Using Dendritic Cells Transfected with Messenger RNA Amplified from
Detection of Gene Amplification by Genomic Hybridization to CDNA Mi- Tumor Cells. David Boczkowski, Smita K. Nair, Jong-Hee Nam, H. Kim
croarrays. Mervi A. Heiskanen, Michael L. Bittner, Yidong Chen, Javed Lyerly, and Eli Gilboa.
Khan, Karl E. Adler, Jeffrey M. Trent, and Paul S. Meltzer Carcinogenesis
Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to an
The DNA Mismatch Repair Genes Msh3 and Msh6 Cooperate in Intestinal A Germ-Line p53 Mutation Accelerates Pulmonary Tumorigenesis: p53- 70 Gene. Chien-Hung Chen, Tian-Li Wang. Chien-Fu Hung, Yangin
Tumor Suppression. Winfried Edelmann, Asad Umar, Kan Yang, Joerg independent Efficacy of Chemopreventive Agents Green Tea or Dexametha- Yang, Richard A. Young, Drew M. Pardoll, and T-C. Wu
Heyer, Melanie Kucherlapati, Marie Lia, Burkhard Kneitz, Elena Avdievich sone/myo-Inositol and Chemotherapeutic Agents Taxol or Adriamycin.
Kunhua Fan, Edmund Wong, Gray Crouse, Thomas Kunkel, Martin Lipkin Zhonggiu Zhang, Qing Liu, Laura E. Lantry, Yian Wang, Gary J. Kelloff
Richard D. Kolodner, and Raju Kucherlapati Marshall W. Anderson, Roger W. Wiseman, Ronald A. Lubet, and Ming You Molecular Biolegy and Genetics
ESThxuipmrrloeerysi sgie1o.n niS cmiittohfy, thoMefi chtWehilell em Lse’Du okwenTm,ui mco Arn CderlSeluw ppLirWn.e es sBoMory1 d ,G ienan nedC, . BC-hW1uT7nI g, scLi.Rd e/Lsdicu icde s Micteh.e GAAerlnydloo t-oKxeHityco d rPoRoceladyrcuycbctolanis ce s ARreoIcmneadputtcioecr . CHMYyidPcrIhoAace1al rbvoiEn.a NouBrcutrlhceoza-yrQn usikTnir oannessaln odc GaetnieTorrnea vtoreo df tbMhy e gISranedcsarsheiiaorsnoi ngT oafmM ieyAtadh,uy lltaT taitsoTun-n Coerolifl tSahLkea eiu,Ck DeHKmiiNrao2.aA k i KiGMseiatntseou ya,INs o saAanskdsa o,c MiaastMaeidoc hiMwyiauttkhsi u otkhMea a ePdrao,-
Penning
Enhanced Nuclear Diacylglycerol Kinase Activity in Response to a Mito- Alterations of the FHIT Gene in Human Hepatocellular Carcinoma. Bao-
genic Stimulation of Quiescent Swiss 3T3 Cells with Insulin-like Growth Zhu Yuan, Catherine Keck-Waggoner, Drazen B. Zimonjic, Snorri S
Factor I. Alberto M. Martelli, Giovanna Tabellini, Roberta Bortul, Lucia Clinical Investigations Thorgeirsson, and Nicholas C. Popescu
FPMaaaonslzLoa:l iF,Na asr duRRcecanita,it oo -aAn Bda rPergogLugic,ni oo stGiiCcoo cvcaoF nancat or Bailnd iBnir,e astV ittCoarrico inGorimlal,s . MaTroirnaal f ZRweeiymeerr aHWSnuaindlgd ehfn otraRL,,ea scttEraiMitniceactr he adLe Kel.v ePlRasoWtf eistetPtnaretder ,dl iicnSatgnu ,dr vLiiWMvkoiaelcllfh iagheaolnio ngd LHMeohufur emklMeale,ent ra -sKtGlaeiCsoeeersrsgev, ri caSTlcu hmwioCcrka enrctRe,er csu.r KroeSltnbecefeia,nn MdKaaurgriienn- gb O4,h mGaean r Nmo vFoerlCs elluMln edl, aDinafonfdme are KnattAianarttiiingaoe nn. No(CrhMdrqAivGsitEsit)n a GeOnstee rlSupnedc,i ficaVlilryp i ExTporheésnseend,
Christina Herrnring, Dirk Koczan, Dagmar Richter, Bernd Gerber, Dieter
Kabelitz, Klaus Friese, and Hans-Jiirgen Thiesen Elevated Frequency and Functional Activity of a Specific Germ-Line p53
Endocrinology Intron Mutation in Familial Breast Cancer. Teresa A. Lehman, Bruce G.
tDAoe. rnidBnragdi etri,oc f aGCee rPlahlla-dsb ea sP.eI dIM uCrlIpimhnmyi,cu anlo atnhTdre iraMla.ip cyhPa aetlro ifc iLa.P roSsAa.lt gaaLtloel er CancLeorr:i AI. mmJounnese, RMoobneir-t MBAoo uuvriNeaordv, e l BJoeuaSrnaM-sPA,i Der4Er rei c GDreoTnza,eb o nea,nM du tJaMatocihqouanem se diB ne rBteShnoealmohinm,ne do.mP aas calG eSromm merC,e ll RaTyummoonrdse. 1070 KIHarnfisfsuthlyn,i ann-,l CihkerP iesteGtror pohGwe.rt hS hiJ.eF ladCcsa,t robro RnaeIm,la SuLMpiopsdala yl iR,. MoadBniidsf hioeBpsr, u ceG rAnoCd.w rtehwT u rnoefAr . InGtuemsbtsin,a l SAhdiev-a
Overexpression of Insulin-like Growth Factor-binding Protein-2 Results in Down-Regulation of Transforming Growth Factor B Receptors by Andro- noma in ApeMit/+ Mice. A. Bassim Hassan and Julie A. Howell
IAnncdrreeaasse d HoefTluimcho,r igOelngiac FetPtostcehnert,i al Harian ld Y-1L ahm,A dreWneorcnoerrt icFa. l BluTmu,m oHre lmuCetl ls.J gTehne odion reO Jv.a Brrioawnn , Caannd ceMri cheClellel s. LetAanrdtre eas Evangelou, Sangita K. Jindal Relating Genotype and Phenotype in Breast Cancer: An Analysis of the
Kolb, Dieter Engelhardt, Eckhard Wolf, and Matthias M. Weber Prognostic Significance of Amplification at Eight Different Genes or Loci
The 4-Pregnene and Sa-Pregnane Progesterone Metabolites Formed in Non- and of p53 Mutations. Marguerite Cuny, Andrew Kramar, Frank Courjal
Susceptibility to Prostate Cancer: Interaction between Genotypes at the tumorous and Tumorous Breast Tissue Have Opposite Effects on Breast Cell Vala Johannsdottir, Barry lacopetta, Héléne Fontaine, Jean Grenier, Stéphane
Androgen Receptor and Prostate-specific Antigen Loci. Wenmei Xue. Proliferation and Adhesion. John P. Wiebe, David Muzia, Juncai Hu, David Culine, and Charles Theillet
Ryan A. Irvine, Mimi C. Yu, Ronald K. Ross, Gerhard A. Coetzee, and Sue Szwajcer, Scott A. Hill, and Jennifer L. Seachrist
Ann Ingles Transcriptional Regulation of Cyclooxygenase-2 Gene Expression: Novel
Androgen Receptor Mutations in Prostate Cancer. Marco Marcelli, Effects of Nonsteroidal Anti-Inflammatory Drugs. Chiun-Jye Yuan, Asim
IDNS109, a Taxane with Oral Bioavailability and Potent Antitumor Activity. Michael Ittmann, Stefania Mariani, Richard Sutherland, Rajni Nigam, Lata K. Mandal, Zhongjian Zhang, and Anil B. Mukherjee
Maria Ines Nicoletti, Tina Colombo, Cosmo Rossi, Caterina Monardo Murthy, Yali Zhao, Dino DiConcini, Efisio Puxeddu, Adel Esen, James
Stefania Stura, Massimo Zucchetti, Antonella Riva, Paolo Morazzoni, Maria Eastham, Nancy L. Weigel, and Dolores J. Lamb Chromosomal Mapping of Genes Controlling Development, Histological
GBieanveadzeztit a Donati, Ezio Bombardelli, Maurizio D'Incalci, and Raffaella Epidemiology and Prevention GYTruokasidhneia,kra iz u DYeoUpssthhhii djai,mo af, TIoMnmavosakasomio in ,N Yomaoamtnaodm, o toSi,Mza es aMeao sfu mTiaRt aetm aStuszSuut,i ,o maTTcaahkk aasshhiiC arKScuuirgnaiommmoutarosa..,
Increased Death Receptor 5 Expression by Chemotherapeutic Agents in Genetic Polymorphisms in Uridine Diphospho-Glucuronosyltransferase 1A 1 and Minako Nagao.
CtNHaoauvrgme-anrnaeeenel,, a teGdlGa inudoo mhAauHp.sao- Jp .t CoaPsSuaiuns ,se -sHi unaJSdneyusgnsc ieiern ggi sJ.t iLcW iegdCadynltdeo, t oxiincV iitsyhV ivtawr oi thM .a Tnud mDioxiritn, NeVcWiervbooss. tiesr M oFtaocKo- aGCnuhidel mleoAmpsersteotcev,ie anttiRioobnoe nr tw iotCf.h AMfBillraleitakosaxtni ,n CaBBenytch e rHN eepawammtaoocnna,gr ciaAnnfdor gieDcnaaevnsi di sA mE.e bryiH coauCsnomsua.mn a.r Cihnan,t ala TgLihroeon wbtech-r Fgeesr o fP arnodMt yeeTilhno-oiTmdya rso sLiE.ne euS kmeiKmtihingaaa slel CSelulpsp resIsnedsu ceCdy tokbiyn e-Bienrd-eApbeln.d eJnatc k OutM-
Natural Benzopyrone That Is a Potent Inducer of Aflatoxin By-Aldehyde
Length and Loss of Heterozygosity of an Intron 1 Polymorphic Sequence of Reductase, the Glutathione S-Transferase AS and P1 Subunits, and NAD-
egfr Is Related to Cytogenetic Alterations and Epithelial Growth Factor (P)H:Quinone Oxidoreductase in Rat Liver. Vincent P. Kelly, Elizabeth M Tumor Biology
aRBneedcc kempBatunornrk,h arEdxK pirrBesrstaesnnid otn H.u tmHaocrhsetr , BueRrgoenra,l d FrSainmkon , GebRhaalrpdht , LelHlae,r tmuWte rneScrh miBdot,e ckeArl,f EMlcliLse, odM,a rgDaarveitd MJ.. JudMaahn,s onG,o rdoSni moE.n NeAa.l , Chanadn asJ,o hn GrDa. emHea yesJ.. Moffat, Ronald cTehre CMeyll 1L9i3n,e0s0.0 AVanuolutk PrBo. teSicnh roIesi jUerps-,R eguAlmaatrae d C.i n SMiuval,t idGreuogr-gree sisL.t anStch efCfaenr-,
Mariska C. de Jong, Sophie C. E. Bolick, Danny F. Dukers, Jerry W
PART-1: A Novel Human Prostate-specific, Androgen-regulated Gene that Experimental Therapeutics Slootstra, Rob H. Meloen, Erik Wiemer, Valerie A. Kickhoefer, Leonard H
PFMMAaeneauratplglh suyyss Lloiaansn,t.tg i oe o, nSRe oC gLheJePrirran oot ymtJ BeoaurnsHmngogos oa mdrae,nni ednr a,HnL 5iduq m1CM2Payae.nnto te rhB iiaSAa .no ydFNarreniolgegsd eomnna nL,in R,e BcaerpJbatamoreras GTerTan.s ek, WhaWinitdel ,l iCalmoC naamEllailritsiy. SHZHD.iDoe gnn4nanP1.ale9 ldq0iR u:nii gcJn. h ,Am Onowg niiAdtlOnh,vrd i arel,elBa wynr dMo iaAPccdP.hte -atiSeevTrlpeh eocmFIDatnu.srhkW ,iuea bsmdi, ts owErlAoJa arninnotteefhi tSKu.Vem anosEdrc.r uelSawtrE, of kfEeiJnscod,an oc tyhB.Oe. r leiSnCatdulear p whGeeCrnunr, or wy,tR L.h a uGrWFreeanadcthg taoemrF gRDHLeiuoinrcmreeieosca,mitn us naenLi Edonf z foeRnScisVhtkicis th mriJoa,. m ofuS crEhaTIve,onpi etmdreoe.rhn lKiceareuzo ku ihnia Kknoodd 1 a2m. aiS,nDh iabnu VSyihavGi,ona -bircihKeAialn zaulnyEDosguriadiswa a, , oTfMa Gakaketkdohaute, o MAaaSnntutdsni uaammnougStreiioaok,,-i
Retroviral Immunotoxin Gene Therapy of Acute Myelogenous Leukemia in Matsuno.
Tamnhader y SGulzEuapcniotncheoe rltiDai. lc oCioCden lzlesRn.e ceTpitmoort hy MedJ.i aMtoersa n,a SSutravciyv alG raSyi,g naClh riisnt inHau maA.n MiMkaosmz- TMPoainxcoiesn k aUlstGiseningse -.MC oyrtDtoaatnroiiex,li c SiTA-. Y iC eVlCallhsle enrT,a, r aannsdN diu BcreuJidcne , wRiJ.t ahm Belsaa zna r.MI .n terRl. eukBianld ri4c/aD,i phtAhnegreilaa aNYnoudoc nl,eI ancrHh uolj MuanLtgeer .i xLe e, ofY uCsaulnr etJiucnugl, inE unsiinl HYeup,a tHoeceel-lBuolma r MoCoanr,c inKoymuay.o unGgh ilS-oSnugk,
A Single Nucleotide Polymorphism in the E-cadherin Gene Promoter Alters Microtubule Disruption Induced in Vivo by Alkylation of B-Tubulin by
Transcriptional Activities. Long-Cheng Li, Richard M. Chui, Masahiro 1-Aryl-3-(2-Chloroethyl)Ureas, a Novel Class of Soft Alkylating Agents. Epidermal Growth Factor-like Ligands Differentially Up-Regulate Matrix
Sasaki, Koichi Nakajima, Geetha Perinchery, Harry C. Au, Dana Nojima Jean Legault, Jean-Francois Gaulin, Emmanuelle Mounetou, Sébastien Bolduc Metalloproteinase 9 in Head and Neck Squamous Carcinoma Cells.
Peter Carroll, and Rajvir Dahiya Jacques Lacroix, Patrick Poyet, and René C.-Gaudreault Pornchai O-charoenrat, Helmout Modjtahedi, Peter Rhys-Evans, William J
Court, Gary M. Box, and Suzanne A. Eccles.
Human MT6-Matrix protei =m| ification, Progelati A Ac- Evaluation of HSV-tk Gene Therapy in a Rat Model of Chemically Induced
tivation, and Expression in Brain Tumors. Gloria Velasco, Santiago Cal Hepatocellular Carcinoma by Intratumoral and Intrahepatic Artery Routes. Induction of Differentiation and Apoptosis by Ligands of Peroxisome Pro-
Anna Merlos-Suérez, Adolfo A. Ferrando, Sonsoles Alvarez, Atsuhisa René Gerolami, Jorge Cardoso, Maité Lewin, Marie-Pierre Bralet, Antonio § liferator-activated Receptor y in Non-Small Cell Lung Cancer. Tsg-Hui
Nakano, Joaquin Arribas, and Carlos Lépez-Otin Cunha, Olivier Clément, Christian Bréchot, and Phuong-Lan Tran Chang and Eva Szabo.
ili
CONTENTS OF VOLUME 60
SN-1, A Novel Leukemic Cell Line with t(11;16)(q23;p13): Myeloid Character-
HiNTsaoatikinjcamishr aoa,a t nad MoNRroeizs,oi smtia MnacseNa iyitotoss uh,Ri e tiTnooYmiadonsha igkiasonaTdwa akV,ii ,t amKioFnhu imciDh3oi. r o YBaessusThhsuoij,di ,e HMaaanysdaa shhiir, o Ta tYsuoStsaohksioh.oi A2Fu0nt0u0nAr seos ouAcnnAinanuctnaiueloa mnl eMefMneoetterits nig nC agnsc er of Retshee arAcmhe rican 1150 CEK. .r r5KaM9o.:t iak He3e 0n7k7e-l3s0 83,a 5n9:d J 169.91 90J. 9-T6u1rc1h2i., 1999
Late-breaking Research Session at the D-C. Yu et al., 59: 4200-4203, 1999.
Anr Meeting
Workshop on Pathobiology of Cancer
Letter to the Editor Workshop on Molecular Biology in
Clinical Oncology 1151 Author index
Correspondence re: Yamamoto et al., Specific p53 Gene Mutations in om Methods in Clinical Cancer
Urinary Bladder Epithelium after the Chernobyl Accident. Cancer Res., 59:
3606-3609, 1999. Wendla Paile. AACR Special Conferences in Cancer
Research
Recent Deaths
Calendar of Events
March 1, Number 5
Advances in Brief Carcinogenesis Tumor Biology
Irradiated Mammary Gland Stroma Promotes the Expression of Tumori- Heterogeneity of Angiogenesis and Blood Vessel Maturation in Human
Chemotherapeutic DNA-damaging Drugs Activate Interferon Regulatory genic Potential by Unirradiated Epithelial Cells. Mary Helen Barcellos Tumors: I for A Tumor Therapies. Anne
Factor-7 by the Mitogen-activated Protein Kinase Kinase-4-c-Jun NH>- Hoff and Shraddha A. Ravani Eberhard, Sebastian Kahlert, Valentin Goede, Bernhard Hemmerlein, Karl H
Terminal Kinase Pathway. Tae Kook Kim, Taeil Kim, Tae Young Kim, Plate, and Hellmut G. Augustin.
Woo Ghil Lee, and Jeongbin Yim. Overexpression of Human Aspartyl (Asparaginyl) B-Hydroxylase Is Asso-
Antitumor Effect of Adenovirus-mediated Bax Gene Transfer on p53-sensi- cMioantteed, waintd h JacMka liR.g nWaanntd s. Transformation. Nedim Ince, Suzanne M. de la HAuutmoacnri ne HeSptaitmouclealtlourlya r MecCahracniinsomm a.b y KoTircahnis forMamtisnugza kiG,r owtMha satFaacktao r DBa tei n
tG.i ve Swainsdh erp,5 3-rLeisn istJia, ntJ acCka ncAe. r RoLtihn,e s. DeSjhiuann sukLaei , KLa.g awCali,f tonJi an StGeup,h ens, Stepahnedn Sensitivity of the Cervical Transformation Zone to Estrogen-induced Squa- FNuokriikyoo FYaumrauskhaiwkai,, YoTsoshhiiyhai to TahSaeskih,i , HiMdaestasnuogrui SMaaittos,u shiMtiak,i o KNaizsuhsihziagwea , SakJiutnaincih.i
Bingliang Fang mous Carcinogenesis. David A. Elson, Rebeccah R. Riley, Ama Lacey Fujisawa, and Kyoichi Inoue
Gudmundur Thordarson, Frank J. Talamantes, and Jeffrey M. Arbeit
SANMesoafsrmfcoa,ict niiiacMat aki,roa ynn -dYA ionzfnMh e otinhogeMt aiscBYt lirnoaC,noe glmelR slu.od So,yl Ffn. dWirBJlraoleamnidei as mcJ hoP,hr Dnoesatwonoenldi,f n , L eDwoainvNtaiahrdt d h aTnBoG. p uoaLAir.oes mnobtEmaelel rirsd,a, s eR Noob[erIrmltaa AiF n GtDhueeit cehcaNtriodon,n r aGonefd oorDmgNe A MD.aA nlkDi. f esJotnaest,i ona ndo fP etter eB. byF ars2meprt Pp Lesbeliing: ons E| vini dVeivnoc. e Yvfeosr IFE)drrTeawonnixtcniie ff yiGi.cHn aagtm VioaounnE, n zMoyefiM mrite ch he elMPeiu ctratoAilsbvoeemr taolnBi r,a iEnp NoixcTiouldmaeso r Hdyed ArnoTtrliiagbsoelene. t, BRFeM7ti/ cGhaEe2l asAl err,a tnhde.M ar(iDeae n-d
IbH.nr taeJnoresl heiuP, krioGtnre-ei1gn3o ryiR ne cEPe.r pitPmloaarur tyz, a EaCxnhpdal ianRna:tj s AK. o fN PouHvruie lm anT umoMra-liagsnsaoncti atGeldi omTarsa. nsBmheamra-t bBMT)ouhopteby airsti,id oFinona oend d- idAnNce itrgiiHevvulae tmdeaJ s n G oSCo-aPdLrheycarmsihpenal oimgo Cebhnle acsktpo2oi-idAn mti nTaoKn-6d1 -mACepetolhlpsyt.lo -si6Hs-u,ip jhuaennn ydl ‘ZiIhmuni,dd uaczAeols(a 4nG ,e5n-Re tIEizxoapnwraa,el ssSiKioeannl ysluo kfe L SeiwaKilusy! m a6mX-o StuEolx,fp or eCsLhesiwikioasnk o Xi n MIsiH tsuIunmovakearn,s elyC AoklCiokorore rcetlKaaalt neadmC oannw,cie trh. KCatoMsniuvnyecunkk -i
CIHsaamrrarbiilos,on ny,lF ahadnRd e dAGulec-otMraugslele a:, D . ASBh iirgNneiokevi e l TsuMcehtiadsa,t asKiosh-jmio duSultaot,i nPga ul FuMnocttlieoyn,. PEaunld omR. FPaarcttiocrlse s. UnRdaesrhil yiInyegr atnhde BCreulcle GEr. owLtehhn-erretl ated Bystander Responses to a OSAah smaoMkriei,c ,h anTiaHstistruionjcai,r i IPsNrhiiesddhaii,, c tiSavnhedi geMRooe idjeiN la Kkaaomnfun raDago,i s e-KRaezsupmoin se KurCautrav-eMsiu raf,o r CKealtl Cyclhei
Altered Expression of Fhit in Carcinoma and Precarcinomatous Lesions of Clinical Investigations Phase-specific and -nonspecific Drugs. Shea N. Gardner.
the Esophagus. Masaki Mori, Koshi Mimori, Takeshi Shiraishi, Hansjuerg
Alder, Hiroshi Inoue, Yoichi Tanaka, Keizo Sugimachi, Kay Huebner, and Increased Urinary Excretion of 2-Hydroxyestrone but not I6a-Hy- Sulforaphane, a Naturally Occurring Isothiocyanate, Induces Ceil Cycle
Carlo M. Croce. droxyestrone in Premenopausal Women during a Soya Diet Containing Arrest and Apoptosis in HT29 Human Colon Cancer Cells. Laurence
Isoflavones. Lee-Jane W. Lu, Melanie Cree, Shylaja Josyula, Manubai Gamet-Payrastre, Pengfei Li, Solange Lumeau, Georges Cassar, Marie
Transforming Growth Factor B2 Promotes Glucose Carbon Incorporation Nagamani, James J.G rady, and Karl E. Anderson Dupont, Sylvie Chevolleau, Nicole Gasc, Jacques Tulliez, and Frangois Te
into Nucleic Acid Ribose through the Nonoxidative Pentose Cycle in Lung
EBpasistihleilaina,l MCaarrtac inCaosmcaa ntCee,l lsa.n d LaWsazilo- NaG.n g BoPraousl, LJeoeh n S. Torday, Shu Lim, Sara Experimental Therapeutics EYsatmraodgae,n JuRneiccehip torKusr ebiany asHhiu,m anT akuMyyae loMomraiy a, CellHsa.r ukToa kemSaik aguOcthsuik,i , HiOrsonaomrui
Antiangiogenic and Antitumor Activities of Cyclooxygenase-2 Inhibitors. Kunisue, Kenichiro Yata, Masako Uno, Yoshihito Yawata, and Ayako Ueki
Further Evidence That the Radioprotective Aminothiol, WR-1065, Catalyt- Jaime L. Masferrer, Kathleen M. Leahy, Alane T. Koki, Ben S. Zweifel.
ically Inactivates Mammalian Topoisomerase II. Ronald D. Snyder and Si n L. Settle, B. Mark Woerner, Dorothy A. Edwards, Amy G. Flickinger Local Imbalance of F Factors: A Potential
DavidJ . Grdina. R n J. Moore, and Karen Seibert Mechanism of Focal Necrosis and ion in Tumors. Saroja Ramanujan
Gerald C. Koenig, Timothy P. Padera, Brian R. Stoll, and Rakesh K. Jai
ICWInihs laolrVfiaiovacromtm esr AFin.z htaCiBtEotis-uor1mno onr, oa fn Aadcn CtdPi hTvCMi-.Et1 -y12 E .oi flH eOyeRndoN rdYo DXloy-lHsau0inm1s.e 5r ibcyIk sh HoIunufsmleau,ne n cKeLadir veenbr y LpCo5ah3rr bbSoatxcayhtl,u ess tLaiennr da sLeiI s CcMXAioiakaapsitoyape-atedLmo ria - .wt irYMtaauhnnt gos,Chp i,os rpHtluiZaint higenG -a SoPh,R -eenTsgyiN psateoa yCnuhckAeeind. ,e noMMisaKuisrunaane,hi ahriTukTr ooi sphKhiohoTmiesarrptaoshd uaa,,t S ausgeTiT yoaamt(msoauAy,hTui Pkk7ioa B n)d S FuuSmIrhsuii knzAa-asiwwscaaho.i- MLMaeautrraiesent-caOetd iicl eP aPnSiroacfodo pote,ua lr(et1t,i,2eC )hs r iasFnotudfi e a nEHr uicm CaroMntats e., PanPcarteraictkiA cct iGviCibaiteynr c, eDre cDroCeemalislnse.is q uMeAu dnheelLs oimvbeAa urbdeaorn.td
AZH.hu agnKmgie,r nn tJeefdf Db. y GiRlabderito,t hDeerlalp yL.. PaKieenllnie,t hJ aeR . HoR ogKuilms,k i,C arSlvae nCd. OH.e isFer, eytaangd, DKaavnidg CABdrnieaacln2o 5g u|.eI n.Cha rirb,Ki etniCjorina igTa anmdWu irlaCce,ol xl, E iClyaecneldn e JCoA.h rnrS eosSut.t hwLbaiyzc ok.a, SyJnetfhferteyi c KeTrhniso, alkKyalt heVriitnae miRno si.K Virology
Overexpression of PTEN/MMACI and Decreased Activation of Akt in
A New Temperature-sensitive Liposome for Use with Mild Hyperthermia: Preferential Enhancement of Tumor by a Cych 2 Human Papillomavirus-infected Laryngeal Papillomas. Ping Zh:
CDhavairda cteNreiezdahtaimo,n aGnodp al TesAtniynagr amibnh ata la,H umaGanr henTgu morKo ng,X enoagnrda ftM arMko delW. IKnahtihbriytno r.M asKoanz,u shJia imeKi shLi., MaSsvfeenr rerP,e tePrhsielni,p JC. oTrodfuillao n, Peatnedr sen,L uka NaMinlcays. Hunter, Bettie M. Steinberg
Dewhirst
Nuclear Factor-«B/Rel Is Apoptogenic in Cytokine Withdrawal-induced Molecular Biology and Genetics Letters to the Editor
FPMMioarorjonpoaghr ro acE.lmI immYnepuilrdclo ,a vleC aemnldel Fn eLtaDa tewuarirtneeh ns.ct hee U o. fDE .f SfhBiKircevrearraca.syj t oSfoC hauBnrR,cC erAC.Ih ihR-MoLusiet tattCeih oenn,L idSeDcroreneaneu,an inJg.F raHUnisgcioknissg, oJMAufu d rRiaotHthlau e,m CafaomnYrpo ikIsodiB- ,r1 eIatiasannth d at nhaePC, i aeAnrgScrgieer-mreYo svnseaiCs ve lel PDsae.rPs rhpieCrnlneelaozlu tody,i pae S coQatintad o HS.t LeirnLo,i iadn gJ,aH ronaCrihmle orynlSe i ngERh. e, sGp oKennsjei 1463 CCLEiaonbnurctcroteide.ris npgoR enRpedsAle.ynn, g cibeoys5 9t:ar Ate. :i 3nJ3 aQ0m-a8eRn-s.d3 31MCE2inh,xde sonos nt1 ae9tt9 i9na.i ., IAnnLhdiirbpeiotws oBmreLe.s a stF elCCdoammnpaclnee rx eadin nd tNou SdtPeelv aesnMm iicdeKs.
Eisinger, Marie-Héléne Champéme, Catherine Nogués, Ivan Biéche, Daniel A Minimal Critical Region of the 8p22-23 Amplicon in Esophageal Adeno-
Birnbaum, Claude Pallud, Jocelyne Jacquemier, and Hagay Sobol. carcinomas Defined Using Sequence Tagged Site-Amplification Mapping
and Quantitative Polymerase Chain Reaction Includes the GATA-4 Gene. Meeting Report
Loss of pRb Expression in Pituitary Adenomas Is Associated with Methyl- Lin Lin, Sanjeev Aggarwal, Thomas W. Glover, Mark B. Orringer, Samir
aMtairoine oMfc Ntihceo l,R B/R icChaprGd NI.s laCnlda.y toDna,v iadn d J. WiSlilmipasmo n,E. FNairgreell l A. Hibberts, Anne Hanash, and David G. Beer. 1465 SPiutmtmsbaurryg h, ofP etnhen syI lvania on OI cCtaonbceerr 3-6M,ic r 1999. Ronald B.f roHme rbMeeremtainn g anidn
CD95 (Fas/APO-1) and p53 Signal Apoptosis Independently in Diverse Cell PPrroossttaattee -spEepciitfhiecl iaTlr anCeslclrsi. ptMiaosna hiFraoc torN ozhaPwSaE, IKse nTtraarnos laYtoemdo gOindlay, inN oNbourfmuamil Theresa L. Whiteside.
Types. Liam O'Connor, Alan W. Harris, and Andreas Strasser. Kanno, Norio Nonomura, Tsuneharu Miki, Akihiko Okuyama, Yoshitake
Nishimune, and Masami Nozaki
Fibroblast Growth Factor Receptor-1 a-Exon Exclusion and Polypyrimi- 1470 Announcements
dine Tract-binding Protein in Glioblastoma Multiforme Tumors. Wei Jin, of aH uman Gili iated Growth Factor Gene, granulin, 2000 Annual Meeting
Ian E. McCutcheon, Gregory N. Fuller, Eileen S-C. Huang, and Gilbert J Using Diff ial I bsorpti Linda M. Liau, Roger L. Lallone, Future Annual Meetings of the American
Cote. Robert S. Seitz, Alexei Buznikov, Jeff P. Gregg, Harley I. Kornblum, Stanley Association for Cancer Research
F. Nelson, and Jeff M. Bronstein Workshop on Pathobiology of Cancer
Inhibition of Constitutively Activated Stat3 Signaling Pathway Suppresses Workshop on Molecular Biology in
Growth of Prostate Cancer Cells. Zuyao Ni, Wei Lou, Eddy S. Leman, and BRCA\I-related Papillary Serous Carcinoma of the Peritoneum Has a Clinical Oncology
Allen C. Gao. Unique Molecular Pathogenesis. John O. Schorge, Michael G. Muto, Sandra Workshop on Methods in Clinical Cancer
J. Lee, Lee-Wen Huang, William R. Welch, Debra A. Bell, Emily Z. Keung, Research
Ross S. Berkowitz, and Samuel C. Mok. AACR Special Conferences in Cancer
Regular Articles mHoigchy toLmeavsel.s oHfe rvTéy rosLien e HiPr,h ospLhucoar ylaG.t ed ColPuroctcoi--RDe’tA maitno ,S porNaidciocla s PheCohcarhlreot-- CRaelcReeennstde aarrD ecahoft hsE vents
Berguerand, Pierre-Frangois Plouin, Xavier Bertagna, Vittorio de Franciscis.
Biochemistry and Biophysics and Claude Thermes.
Tetrocarcin A Inhibits Mitochondrial Functions of Bcl-2 and Suppresses Its BRCAI and BRCA2 Have a Limited Role in Familial Prostate Cancer. 1472 Errata
AMnittis-uanpoobput otHiarca . Activity. Takayuki Nakashima, Masayski Miura, and CTohlilbeoedne au, Schanedh i FerSignuclsa Jir.,C oucRhe.b ecca Berry, Daniel Schaid, Stephen N AA.. PB. oMncaGtelti ay l.ne,tn 60 a: l.7,2 589-: 7352,9 12-2500901.6
The Tumor Growth-inhibiting Cell Adhesion Molecule CEACAMI (C- Class A Helix-Loop-Helix Proteins Are Positive Regulators of Several Cy-
CAM) Is Differently Expressed in Proliferating and Quiescent Epithelial clin-dependent Kinase Inhibitors’ Promoter Activity and Negatively Affect
Celis and Regulates Cell Proliferation. Bernhard B. Singer, Inka Scheffrahn, Celi Growth. Alfredo Pagliuca, Pasquale Gallo, Pasquale De Luca, and Luigi 1472 Correction
and Bjérn Obrink. Lania. S. Bettuzzi et al., 60: 28-34, 2006.
DNA-dependent Protein Kinase Stimulates an Independently Active, Non- Diversity and Frequency of Epidermal Growth Factor Receptor Mutations in
homologous, End-Joining Apparatus. Steven J. DiBiase, Zhao-Chong Zeng, Human Glioblastomas. Lori Frederick, Xiao-Yang Wang, Greg Eley, and C.
Richard Chen, Terry Hyslop, Walter J. Curran, Jr., and George Iliakis. David James 1473 Author index
CONTENTS OF VOLUME 60
March 15, Number 6
Review Genotype-specific Trp53 Mutational Analysis in Ultraviolet B Chromosomal Fragile Site FRA/6D and DNA Instability in Cancer. Marie
Radiation-induced Skin Cancers in Xpc and Xpe Trp53 Mutant Mice. Mangelsdorf, Karin Ried, Erica Woollatt, Sonia Dayan, Helen Eyre, Merran
Antonio M. Reis, David L. Cheo, Lisiane B. Meira, Marc S. Greenblatt Finnis, Lynne Hobson, Julie Nancarrow, Deon Venter, Elizabeth Baker, and
Genetics and Biology of Adult Human Male Germ Cell Tumors. R. S. K Jeffrey P. Bond, Dorit Nahari, and Errol C. Friedberg Robert [. Richards
Chaganti and Jane Houldsworth
Advances in Brief UTlrtpr5a3v,i oleatn d BA peRxa di(aHtAiPo1n)- inGdeunceesd: SGkeinno typCea-ncsepre ciinf iMci ceE ffDecetfse ctoinv e Cainn cethre XPprec-, A 700-kb Physical Map of a Region of 16q23.2 Homozygously Deleted in
disposition and Pathology of Tumors. David L. Cheo, Lisiane B. Meira Multiple Cancers and Spanning the Common Fragile Site FRA16D. Adam
Nuclear Expression of the c-erbB-4/HER-4 Growth Factor Receptor in Dennis K. Burns, Antonio M. Reis, Tony Issac, and Errol C. Friedberg J. W. Paige, Karen J. Taylor, Aengus Stewart, John G. Sgouros, Hani Gabra.
Invasive Breast Cancers. Radhika Srinivasan, Cheryl E. Gillett, Diana M Grant C. Sellar, John F. Smyth, David J. Porteous, and J. E. Vivienne Watson.
Barnes, and William J. Gullick
Clinical Investigations
MFUA. osriennnJi. gtd overa Pnio VnsrgiiWet sar.ao ornfd eH,Ee mripPseestsir oa nS DiomzTpeo.l meoxg WriaVliplrehumys . VTaGahelybkmueir gd,i An. e NP.a nKHnioons apseeHr. s , EMunlzAdnyenrma,e CaalAncodtg ievrEiroti.yk CHPearnonsgchnaeolrls ,t iTcr DeaSaritrgeendni ficwRai. nthc eH eaRodaf,d ipcSa3Dl a vNiudPc rloesGatorla otveAsccktyco,um myu.l Ja. tDiaDovanivd i di n| . WLioQlcusiaonlnni,,z ed PShuPislralonisp t atMCe SeSloulimz aantniec SeEMq.u uteHanitlceie,os n G uaRinantg e s NYaona,n ntdu maSnopdre icigKfreiincsitiitcni es A.H atuE cmkTaeCnrt/ AG Lyamnpdh oGbTl/aCstAo idM icroCselalts-.
Brenner, Jennifer J. Turner, Warick Delprado, John F. Finlayson, Phillip D.
Fusogenic Membrane Glycoproteins As a Novel Class of Genes for the Local Stricker, John J. Grygiel, and Robert L. Sutherland DMBTI Encodes a Protein Involved in the Immune Defense and in Epithe-
and Immune-mediated Control of Tumor Growth. Andrew Bateman. lial Differentiation and Is Highly Unstable in Cancer. Jan Mollenhauer
Francis Bullough, Stephen Murphy, Lisa Emiliusen, Dimitri Lavillette, Frangois Prognostic nificance of the Metastasis-inducing Protein S100A4 (p9Ka) Stephan Herbertz, Uffe Holmskov, Markus Tolnay, Inge Krebs, Adrian Merlo.
Loic Cc Roberto Cattaneo, Stephen J. Russell, and RichardG . Vile in Human Breast Cancer. Philip S. Rudland, Angela Platt-Higgins, Christine Henrik Daa Schrader, Daniel Maier, Frank Breitling, Stefan Wiemann.
Renshaw, Christopher R. West, John H. R. Winstanley, Lynne Robertson, and Hermann-Josef Gréne, and Annemarie Poustka
Cell Permeable Bcl-2 Binding Peptides: A Chemical Approach to Apoptosis Roger Barraclough
Induction in Tumor Cells. Jia-Lun Wang, Zhi-Jia Zhang, Swati Choksi
Sainmde iZ iwSehia n, HuZahnigx ian Lu, Carlo M. Croce, Emad S. Alnemri, Robert Korngold, Endocrinology AA guDsNtiAn DChaimcaasg,e MSaigganlail IOsl iRvieeqru,i reYdo ichfior pT5a3ya , to SAacntjiavy ate Tygaagid,d 45.F redG u RuXisaeol.l
1503 Antiangiogenic Gene Therapy of Cancer Utilizing a Recombinant Adenovi- Peroxisome Proliferator-activated Receptor y Ligands Inhibit Estrogen Bio- Kramer, and Jill Bargonetti
rus to Elevate Systemic Endostatin Levels in Mice. Andrew L. Feldman, synthesis in Human Breast Adipose Tissue: Possible Implications for Breast
Nicholas P. Restifo, H. Richard Alexander, David L. Bartlett, Patrick Hwu. Cancer Therapy. Gary L. Rubin, Ying Zhao, Allan M. Kalus, and Evan R
Prem Seth, and Steven K. Libutti Simpson Both Normal and Transforming PCPH Proteins Have Guanosine Diphos-
phatase Activity But Only the Oncoprotein Cooperates with Ras in Activat-
Deoxyguanosine Adducts of t-4-Hydroxy-2-nonenal Are Endogenous DNA Le- ing Extracellular Signal-regulated Kinase ERKI. Juan A. Recio, J
sions in Rodents and Humans: Detection and Potential Sources. Fung-Lung Epidemiology and Prevention Guillermo Paez, Baishali Maskeri, Mark Loveland, Juan A. Velasco, and
Chung, Raghu G. Nath, Joseph Ocando, Akiyoshi Nishikawa, and Lei Zhang Normal Bronchial Epithelial Cell Expression of Glutathione Transferase P1, Vicente Notario
oSSETnhurs igaumidkiyGiazalcmumaoa,at tn,oid ,ou nl YaTurszDu KuitormjoSuiim t nuoi smNhIaKokeaczesthah sk auir,yaE a,Cn mahara,cn MiKciencinoahn-ngiigdeoc n heiMEs afisfKsaea ecmI tniasnid inaT s,ao htfMie ,omH naHegtalsoiyulSca hioouba anc tNeKaGruke raranbpmiiyosllhtosior.,,i NIonbfTAueetctystsuuiuskoyhinia GWwJA.il.i tuDlhtOul larsithBoahanri,mmo o, Jnn .ceah n FModeaT grrreekJanna ncimsaceFfk sre, a rCmaCpa.sCt roeocn Wnisi,Mntl 3laoe,nmyM ca aea.r n kd AE.GrU tilenulJ lte,na Lnti.hWn giisol,Cln rieaaw fmJo PerfedfGr,r. oe yx SiTadhdRiai.ls kle y, H aAIm.sD m aeLvKroihswdul deeyirA,n,. SWuSebDaajamvenueciartelsl aRXTneesdsur pkoeadscMeati rinvmoeMar a tRsPPouilhneogastgm aoe,pon rft ooOCdssyuuaccmlmt osub Au tiNnaCi enklaeUlil sdt.o r,Pa yvEririoiSlmkaeoint dg i-nTOMeatoue s thiaD, giKemienmT,rea ssk,ais sKh ei(n 6io-cfYh4 aig) iRP,e hpHoaittiTooromp-sihdr,ieo ofd iucMcMiitoetrsnui,to
Ikenaga, and Takeshi Todo
Eradication of Disseminated Lymphomas with CpG-DNA Activated T Chromosomal Aberrations in Lymphocytes Predict Human Ca
Helper Type 1 Cells from Nontransgenic Mice. Oliver Egeter, Ralph pendently of Exposure to Carcinogens. Stefano Bonassi, Lars Hag
Mocikat, Kamran Ghoreschi, Andreas Dieckmann, and Martin Récken Stromberg, Alicia Huici Montagud, Hakan Tinnerberg, Alessandra Forni, Pirjo TSG101 Protein Steady-State Level Is Regulated Posttranslationally by an
Heikkilé, Saskia Wanders, Peter Wilhardt, Inger-Lise Hansteen, Lisbeth E Evolutionarily Conserved COOH-Terminal Sequence. Guo Hong Feng
Abnormal RNA Expression of 11p15 Imprinted Genes and Kidney Devel- Knudsen, and Hannu Norppa, for the European Study Group on Cytogenetic Chih-Jian Lih, and Stanley N. Cohen.
opmental Genes in Wilms’ Tumor. Christine Schwienbacher, Adriano Biomarkers and Health.
Angioni, Rosaria Scelfo, Angelo Veronese, George A. Calin, Gabriella
Massazza, Izumo Hatada, Giuseppe Barbanti-Brodano, and Massimo Negrini Association of SRDSA2 Genotype and Pathological Characteristics of Pros- Tumor Biology
pLlaeys.e redC hadE xpR.r esEnsgiloernt , ScGaanlinnian g:V . RBaapibiadk ovM,o leacnudl aMri chPareolf ilRi.n g Emomf erTtu-mBourc k Sam- tWMaeaticenB ,r iTduaemn,do rsTR.ii mcohtaJhrulydi e PR.eM s.c RheelbJ,ba fefce,Jk o hnS. TBormuacsez ewMsaklik,o wicKze,i th AVmayn AHr. sdaWlaelnk,e r, AlaSn amJ GEfrfoewctt h ofi nC yMcoluosoex ygTeunmaosre Maondde lsN itwriitch Oaxnidd ew itShyonutth aseC anIcenrh ibCiatcohresx ioan RTeluamtoerd
Potential Role of BRCA2 in a Mitotic Checkpoint after Phosphorylation by to Prostanoids. Christian Cahlin, Johan Gelin, Dick Delbro, Christina
hKaBtaUgBirRi1, . ShMiagnetaobyuo FSaujti,a muYrao,s hioH irMoikfiu,m i andA raYkuaswuak,e KNoaickhaim urMaa tsuda, Toyomasa Experimental Therapeutics Lénnroth, Chiharu Doi, and Kent Lundholm
nergistic Enhancement of Herpes Simplex Virus Thymidine
EWS-FLII, EWS-ERG, and EWS-ETV1 Oncoproteins of Ewing Tumor inase/Ganciclovir-me Cytotoxicity s ydroxyurea. Paul Frequency and Prognostic Impact of Microsatellite Instability in a Large
Family All Suppress Transcription of Transforming Growth Factor B Type Boucher, Leo J. Ostruszka, and Donna S. Shewach Population-based Study of Endometrial Carcinomas. Nicola D.
Il Receptor Gene. Young-Hyuck Im, Heung Tae Kim, Cecile Lee, Danielle MacDonald, Helga B. Salvesen, Andrew Ryan, Ole-Enk Iversen, Lars A.
Poulin, Scott Welford, Poul H. B. Sorensen, Christopher T. Denny, and Akslen, and lan J. Jacobs.
Seong-Jin Kim Photodynamic Therapy-mediated Oxidative Stress as a Molecular Switch
for the Temporal Expression of Genes Ligated to the Human Heat Shock
MFaocdtuolra/tPihoons phoaft iHdyyploixnioas-iitnodlu c3i-blKei nFaasceto/rP TlEaN /EAxKprTe/sFsRioAnP bPya tthhew aEyp iidne rHmuamla nG roPwrotsh- aPnrdo moChtaerrl.e s MJa. riGaonm erC. Luna, Angela Ferrario, Sam Wong, Anita M. R. Fisher RHoolrem oonfe -Mrietloagteend- actPievpattideed. PFraostiekian KAkilnilaus,e s Jiunl ietnhnee InGldaudcut,i on Daovfi dP arGaotlthzymraoni.d
tate Cancer Cells: Implications for Tumor Angi is and Therapeutics. Hua and Shafaat A. Rabbani
Zhong, Kelly Chiles, David Feldser, Erik Laughner, Colleen Hanrahan, Maria: The Role of Apaf-1, Caspase-9, and Bid Proteins in Etoposide- or Paclitaxel-
Magdalena Georgescu, Jonathan W. Simons, and Gregg L. Semenza induced Mitochondrial Events during Apoptosis. Charles L. Perkins, Guofu
CGRVeioecuoccsrehedpipitop,noe ra teDE M’x arpAUiirpuaet- soR,s eiVgo. uMn.l aCtiaPnira rtoirBneir rzeoi,aao sft S tSoRCppolpase]ral c liiD,nN FoAon-matbanii,d. n dMianPArganco tlooan elSlAaFalcr vtaaintvZcoiaortn,eny .e ttiaG,n edr aSriUdlrovo aknia BnoatDsteiel Fang, Caryn Nae Kim, andI mKampiul nN.o lBhoalglay CCMIonoanlnreott riienHjc.un to aFulM.. s B.L BiAoGvrd.ee mrli GneibRMsbietintkrnaekass,t,t i aosnaeE nswd aofn Ea mfiAtDlen.erg ioREPsi.att crahtVtiioiea,enl s t ITHnhheeipoba ittesJ. c tMoA. cmcyeV..l ervaTatone md VrAGo. roonwhDrotivhxel enr,o f
Heterogeneous Expression of the SSX Cancer/Testis Antigens in Human
Transfection of C itutively Active Mitogen-activated Protein/Extracellu- Melanoma Lesions and Cell Lines. Nuno R. dos Santos, Ruurd Torensma.
lar Si l-regulated Kinase Kinase Confers Tumorigenic and Metastatic Teunis J. de Vries, Marco W. J. Schreurs, Diederik R. H. de Bruijn, Ellen Fas Drives Cell Cycle Progression in Glioma Cells via Extracellular Signal-
Potentials to NIH3T3 Cells. Danny R. Welch, Toshiyuki Sakamaki, Ralph Kater-Baats, Dirk J. Ruiter, Gosse J. Adema, Goos N. P. van Muijen, and Ad regulated Kinase Activation. Hisaaki Shinohara, Hideo Yagita, Yoji Ikawa
Pioquinto, Timothy O. Leonard, Steven F. Goldberg, Qiufang Hon, Raymond Geurts van Kessel and Naoki Oyaizu
L. Erikson, Manuel Rieber, Mary Strasberg Rieber, Deana J. Hicks, Joseph V
Bonventre, and Alessandro Alessandrini Preclinical Evaluation of “Whole” Cell Vaccines for Prophylaxis and Ther-
EASRtWdoeeSfnb-aonFC vL.iIBra HIruot.sle , beEHnP1ee iAtne rr iDcohFe s. AK omNvboartro ,s I, ndFruDictaesv e tJ.h eN.F aEllwTa.iu xn,Ag r yeeIT,nu gmroiJdr o-aoPspris bCoilc.li, A a. tDeG d. GWieengea ntF,S uf siaonnd GatS.oph iye lTMdrUasar,st niisnndg,S. u caeT Co .Dd irCsyLyak.t,b o lkeHRido.n lemVI einslfe,G,e e cnteiRSs..o .u sAR .Se .eS dRieonrAbg.,i l nesA ,l iCC,. yacClnE.nedt- SwR. H i.selM reCcp,.L eesRa eneDs.,S . i mMp.l exEB. laVGk.ie lreuyBs,o urVsencJe.t lolGr A2FWu0ont0ru0nAkr sesos houAocnAnipnnau cntauieloao nlmn MePefManeoetrtt heiotsCnbiag inn ogclseo rg yof Retoshfe e arAcCmhae ncreri can
Workshop on Molecular Biology in
Regular Articles The B-CateMnoinl eBcinudlinagr DomBaiionl oofg yAd eanonmdat ouGse nPeoltyipocsiss Coli Is Sufficient WorCklisnhiocapl oOnn cMoleotghyo ds in Clinical Cancer
for Tumor Suppression. le-Ming Shih, Jian Yu, Tong-Chuan He, Bert Research
Vogelstein, and Kenneth W. Kinzler AACR Special Conferences in Cancer
Carcinogenesis Research
Constitutive Expression of Insulin-like Growth Factor-1 in Epidermal Basal Identification of Differentially Expressed Genes in Human Prostate Cancer Calendar of Events
Cells of Transgenic Mice Leads to Spontaneous Tumor Promotion. John Using Subtraction and Microarray. Jiangchun Xu, John A. Stolk, Xinqun
DiGiovanni, David K. Bol, Erik Wilker, Linda Beltran, Steve Carbajal Zhang, Sandra J. Silva, Raymond L. Houghton, Masazumi Matsumura.
Samantha Moats, Angel Ramirez, José Jorcano, and Kaoru Kiguchi Thomas S. Vedvick, Kevin B. Leslie, Roberto Badaro, and Steven G. Reed 1775 Author Index
April 1, Number 7
Review Gene Transfer into Brain Parenchyma Elicits Antitumor Effects. Hassan Antibody Response to the Tumor-associated Inhibitor of Apoptosis Protein
M. Fathallah-Shaykh, Abdallah I. Kafrouni, Li-Juan Zhao, George M. Smith, Survivin in Cancer Patients. Jacques Rohayem, Petra Diestelkoetter, Bernd
pR5e3v ieAwn.t ibTohdiierersy iSno usthsei Sera of Patients with Various Types of Cancer: A and James Forman and Ernst AnPtejtee r OeRhiembiecrh en, Mare Schmitz, Juergen Mehthorn, Karsten Conrad.
Relative Reciprocity of NRAS and PTEN/MMACI Alterations in Cutaneous
Melanoma Cell Lines. Hensin Tsao, Xue Zhang, Kianna Fowlkes, and Frank
G. Haluska Inhibitor of Apoptosis Protein hILP Undergoes Caspase-mediated Cleavage
Advances in Brief during T Lymphocyte Apoptosis. Daniel E. Johnson, Brian R. Gastman, Eva
Cyclooxygenase-2, a Colorectal Cancer Nonsteroidal Anti-inflammatory Wieckowski, Gui-Qiang Wang, Andrew Amoscato, Scott M. Delach, and
Acute Doxorubicin C icity Involves Cardiomyocyte Apoptosis. Olli Drug Target, Is Regulated by c-MYB. Robert G. Ramsay, Annabel Friend. Hannah Rabinowich
J. Arola, Antti Saraste, Kari Pulkki, Markku Kallajoki, Martti Parvinen, and Yotta Vizantios, Ruth Freeman, Catherine Sicurella, Fleur Hammett, Jane
Litsa-Maria Voipio-Pulkki Armes, and Deon Venter
Antitumor Activity of Endostatin against Carcinogen-induced Rat Primary Identification of B94 (TNFAIP2) as a Potential Retinoic Acid Target Gene in
Mammary Tumors. Gianpaolo Perletti, Paota Concari, Roberto Giardini, Estrogen Receptor Protects p53 from Deactivation by Human Double Mi- Acute Promyelocytic Leukemia. Michael E. Rusiniak, Min Yu, Douglas T
Emanuela Marras, Francesco Piccinini, Judah Folkman, and Longchuan Chen. nute-2, Guozhen Liu, Janice A. Schwartz, and Sam C. Brooks. Ross, Erin C. Tolhurst, and James L. Slack
Vv
CONTENTS OF VOLUME 60
Oncogenic Base Substitution Mutations in Circulating Leukocytes of Nor- 1908 Lysis of MYCN-amplified Neuroblastoma Cells by MYCN Peptide-specific Loss of Expression of Dpe4 in Pancreatic Intraepithelial Neoplasia: Evi
mal Individuals. Vincent L. Wilson, Xiugin Yin, Barbara Thompson, Kerry Cytotoxic T Lymphocytes. Asis K. Sarkar and Jed G. Nuchtern dence That DPC4 Inactivation Occurs Late in Neoplastic Progression
R. Wade, Jeremy P. Watkins, Qi Wei, and William R. Lee Robb E. Wilentz, Christine A. lacobuzio-Donahue, Pedram A
HITsyasakp,a esrhRmia eltphhUey kliH,a. tiHoMrniu nboarnu,of anTModuy lottMaii,pc lhea eTla yGleoGrno gegsiS onhsni ,n CPhaanrclreesa ticJ. YeoA,d enoJecaanr-Pciiernroem a. J (MARabeeecdroar,va enritIn k)u oE xpiWnra deasC,sa inocnNeo rri oyfu CkeilP l SaLtoi,n es.Y os“hAikoi k-esK puercoMikafiei,dc a , Canadl HciiTroauskmha-is bhii nOdhNgiaunkrgoa ,g aPwraoT taediano MHre t f
ENJAxoe dpuiSrrepe olsieLsc.n eed dEo dcVgraisinro ninSa,em n atl PGlee nonefCle elslta lh e aJL.n uNdWne ouglrl a,o nC-aUasrnneecdfse utrlr:J i ochCtnAl i ivnPPe.io ctaQeluSn iitnlineaM.nla c rekrRe orl.eF acitnJo urdDy e rReMep.pr reesCssosiuoolrns onoI fs NRRTueehdsetoi wldofuHr auklGm rauCHbnoea rlv,oe r AencNLttoeia omln oIaunrsfdleuCu asen ncIecrmeJ . m uMoTn.nr o egaCvtllaeoind nb iucHlawaliia trnhl O eumM,Rt oecnsoopSmcovelne nso eni anO l. a PnadWtAa inrentntaithabser o,d wyAi nttEhil -eiCnMdaOii 1no7tiH-ymo1plaAizl.c tIwMonaisyrtus-ol.igi nend-nMul-aciarekc edt ivGaArtpoeowpdtAt ho sPirsFo atcetbioynr -1PK oitnPearnsoteti eacttaisnc g NCTuolucolmne oarr CanNFceaeccrrt oosrCie sl l«sB F afcr—toomr Da e-aitnhd PuacFtaehcd--
nd Gert Riethmiiller
Nuclear Factor-«B Activation Is Involved in LMP1-mediated Transforma-
tion and Tumorigenesis of Rat-1 Fibroblasts. Zhimin He, Baozhong Xin Resistance to Lysis by Cytotoxic T Cells: A Dominant Effect in Metastatic
Xinhai Yang, Ching-ping Chan, and Liang Cac Mouse Prostate Cancer Cells. Hon-Man Lee, Terry L. Timme, and Timothy Detection of Hypoxia in Human Squamous Cell Carcinoma by EFS Binding
C. Thompson, Hahn, Deird Timoth kins. A
Regular Articles Granulocyte Macrophage Colony-stimulating Factor and Interleukin 4 En-
hance the Number and Antigen-presenting Activity of Circulating CD14*
and CD83~* Cells in Cancer Patients. Michael D. Roth, Barbara J. Gitlitz
Biochemistry and Biophysics bMe.r t KAi.e rtFsicglhienr., Alice N. Park, Marcy Mendenhall, Nancy Moldawer S-phase Arrest and Apoptosis Induced in Normal Mammary Epithelial Cells
Unrepaired Fjord Region Polycyclic Aromatic Hydrocarbon-DNA Adducts by a _— Retinoid. Yuxian
in ras Codon 61 Mutational Hot Spots. Tonko Buterin, Martin T. Hess Rainbow Lulu Fart
Natalia Luneva, Nicholas E. Geacintov, Shantu Amin, Heiko Kroth, Albrecht Molecular Biology and Genetics
Seidel, and Hanspeter Naegeli VAL Alterations in Human Clear Cell Renal Cell Carcinoma: Association
with Advanced Tumor Stage and a Novel Hot Spot Mutation. Hiltrud Fibrinogen Assembly, Secretion, and Deposition into Extracellular Matrix
Carcinogenesis Brauch, Gr Weirich, Jiirgen Brieger, Damjan Glavat, Heinz Rédl, Mariola by MCF-7 Human Breast Carcinoma Cells. Bria R k F
Matthias Feurer, Eberhardt Weidt, Chutintorn Puranakanitstha Simpson-Haidan
and Ni induced Primary Tumors of the Central Neuhaus, Sigmund Pomer, Walburgis Brenner, Peter Schirmacher
Nervous System in Fischer 344 Rats Exposed to Frequency-modulated Stephan Storkel, Michael Rotter ndrej MaSera. Nadja Gugeler, and Hans:
RMoibcerrot wavJ.e HigFgiienlsd,s . RWo. bertR oss A. AJdoenye,s , CCrhaairgl esV . J.B yuKse,a n, ChrNiiesltso pheKurs ter,D. CA: nne Joachim Decker C1a,n2c5e-rD ihCyedlrlso xytvoi taCmhienm othDe3r apaynd- indAulcle-tdr anCse-lRle tiDneoaitch . AQin cid W SensitizWe BrY east
MacMurray, Robert B. Stagg. and Grenith Zimmerman High Resolution Chromosome 3p Allelotyping of Human Lung Cancer and MyrnSa. Uyting S 1 Christak and Rot W
SmCCHeeahalwterekhmoc,ytol lipyovrnerae n nEdvi .et nhTRCoiotoxlnnieiea,vc liedt yKT ernAe.dE aafrgtLfaauim ibceneancsTttuy tt scho,fA o pf cAM ipceCh MoaumeMtlbua itnnatAen . dt NeEwmMtibPonrin y,r ooxsMi.oGc uaarsymRe u ssKeeAllalldno edff n,o Fm. a_EsDri,nJfe alscutoo abrnyod -T PtFMairirneincunn iaoeaccuiho osg pr ulbaS,|. si tteiWsci s/LoMtuPcf iur bcGea3hii,par nea vrldaA .ls lieIC.vl aeer L meehLnnroB msrasWonB. n, e charhnFeidonSa sntl,de TophhnrEe epnAei rI tIvI,hi RneedlLHg aimai,u roKmon.l sAd d RiVo eiRfrv. mFe.Faa GnrlaieGsr,aqn ezurdeM,aunG rlit tn iBapr Blurece,Me ea lkep,MDo ciis ncKtSoasanr.-ya BGMJeCionRceh-hsnA aM Be.Llp rG oo lpTdWyr.aN.re ogsaDicenie e inK intahsee eAcmti vityir a, eRReg ulReoazzftel ie s¢ sthoe osEx prMeysesliBoeoiantde ofL SecuMhukullettmhii pal.e
Clinical Investigations LRP-DIT, a Putative Endocytic Receptor Gene, Is Frequently Inactivated in
Non-Small Cell Lung Cancer Cell Lines. Chun-Xiang Liu, Simone Musc Glucocorticoid Receptor Gene Mutations in Leukemic Cells Acquired in
fAo r PhaBsieol ogIi cTarila l aonfd theC liFnaircnaels y! ActTirvaintys.f eraAsleex InAh. ibiAtdojrei , SCHCh6a6r3le3s6 : ErElviicdhemnacne Natalia M. Lisitsina, Eva Forgacs, John D. Minna, and Nikolai A. Lisitsyn MViitcrhoa ela ndR. Nino rmaVinv,o . anAc ndrew G. Hillma R as, Kir
HKJaienrnsnsyoc nhm,e N.i erPD,ah vyilsl,ai nsd DSacAov. tit dS vLHi..n g CeKunat,lu efr,m aPnanJm.efe fl a A. SAltohaenr,t on,R andWo. lph RobS.e rtM arksB,i shoLpo,r eleiP aulJ GtMieoonnh ea mofmA meOpdcl ciufliKtca sahtainToiun-smS oarbe tC,h CaerlalHcset nerniiinz neg t heAH carmSalmu ,r rMoeuTlnoadnnyi onmgGa o dfSrakeinynd,. —DB an H.C c.t hMeo Bo Dreet ec- Announcements
Eva-B. Brocker, Philip E. LeBoit, and Dan Pinkel
Experimental Therapeutics ciation for Canc
pAenrtiimaenngtiaolg enicD ruSgc-hreedsuilsitnagn t of CChaenmcoetr.h eraTipmyo thyI mproBvreosw derE,f ficacyC atahgeariinnes t Ex- CMBouetnrasnteaiqroudne sCn .ce iBnsr otuhageth totXnhPe,C CeGDleal,nn iee Plraei nt ePiFineat,mr ai,l ainedsT izTiwrainatanh scNXraeirdrpoto, deLreAmvleails so.n P iFBgrrmoaweniznt tt,o sCuhAmalv aann anneRd n PMaotlheocbuilo l
Butterfield, Birgit M. Kriling, Bin Shi, Blair Marshall, Michael S. O'Reilly nd Miria Stefanini
and Judah Folkman.
Adenosine-mediated Killing of Cultured Epithelial Cancer Cells. Catherine Molecular Determinants of Apoptosis Induced by the Cytotoxic Ribonucle-
P. Barry and Stuart E. Lind ase Onconase: Evidence for Cytotoxic Mechanisms Different from Inhibi-
tion of Protein Synthesis. Mihail S. lordanov, Ol P. Ryabinina t Deaths
Antileukemic Activity of Fit3 Ligand in Murine Leukemia. Abing Wang Wong, Thanh-Hoai Dinh, Dianne L. Newto' Susanna M. Rybak.
Stephen E. Braun, Guru Sonpavde, and Kenneth Cornetta Ma;
Immunology Tumor Biology Erratum
Anthracyclines Trigger Apoptosis of Both Go-G, and Cycling Peripheral 1995 Expression of Metallothionein II in Intestinal Metaplasia, Dysplasia, and
Blood Lymphocytes and Induce Massive Deletion of Mature T and B Cells. Gastric Cancer. Matthias P. A. Ebert, Thomas Giinther, Juliane Hoffmann
Carole Ferraro, Laurence Quemeneur Annie-France Prigent, Catherine n Yu, St an Miehike, Hans U. Schulz, Albert Roessner, Murray Korc
Taverne, Jean-Pierre Revillard, and Nathalie Bonnefoy-Berard Peter Malfertheiner Author index
April 15, Number 8
Review Expression of the hTERT Gene eh regrae at the Level of Transcriptional Complete Sequencing of TPS3 Predicts Poor Response &t o Systemic Therapy
Initiation and Repressed by . Cagatay Giines, Serge Lichtsteiner. * Advanced Breast Cancer. Els M
Alain P. Vasserot vepenr ts Menor Maxime P. )
Nuclear Structure-Gene Expression Interrelationships: Implications for Ab-
errant Gene Expression in Cancer. Gary S. Stein, Martin Montecino, André
J. van Wijnen, Janet L. Stein, and Jane B. Lian. Metabolites of 2’-Fluoro-2’-deoxy-v-glucose Detected by !9F Magnetic Res-
onance Spectroscopy in Vivo Predict Response of Murine RIF-1 Tumors to
Advances in Brief 5-Fluorouracil. Paul M. J. McSheehy, Martin O. Leach, Ian R. Judson, and
fiths.
Endocrinology
Adenoma-specific Alterations of Protein Kinase C Isozyme Expression in
SKAtapemvceesMn,I N CJ.r MiZciee.s merI,re ne PatKr.i ck KleCi. n, RocShtee,v en SaRn.d ra RitlJa. ndG,e ndlLera,w rencaned WJ.i llBiuarmg artE gtIeirroragacedtniieaostnii.so n SAluoafpn par eCsP.sr iiHaomrnat rfoyr adt, Tau mDoiTrsat,kea slh iU nSilGtioekh:eo ngPiSo,ut rengtiDicaaaill FRRuoeklumemo uvraoafl, , H oaEsnntdh- aTnRuacmkeoesrs h AInnK- - CnCooyhmteaon c hrCoelmle Lc¢i meIss. InvAnodlrveeads inG ewFiaes -mediastk ed: ee2 kh of Pror staMti c Carci-
Fit3-Ligand Induces Transient Tumor Regression in an Ectopic Treatment Jain
SMRPIAauinottclddirhiquieuancclrride ada c oRJfP.Aa . pah donmeMCpdaAaitn najo,gvso Eaeixrrlsi ri sasDu, iH liipi:n on KkdCeo HnnunsoEemKlxtvauhhomni, ba irDt G. eHoeaSrpD hgoaaSetmri o,eg crnesLCilc f. lRiW uecrRliaiokangyotrh t, RAC.M naaatsrniBudcrpn iorawonPgnlaoa,ium, fl a e rPWFa.ri tCoAlieSkslviltcierlaha a tme e lEL fliYfhFne.aaCe cmasmt.anGm lcneaeorasMrin sd.d , ItPnhatrteohruWwlgiaehlyul kiiaan im n S iL6g. nLaNlFACa cratrPaiT rvr aatPnersso dsutacAteenr d rCaoangndec ne rA cRtCieevclaeltspo.tr o rTo-afmo esTdhrieanangts ecdrC ihpentG,ie onne L i 3-HEduxeapp reenWsdaseinnogtn SRSoaelkmpuaopmb tolteeo , FOorKrgomajn io f.E oxfITn KpouuoemVei,a ocrhsrici K uimlyaAoeTnrsagn hiki ta yEaanSmdlhaoi ,tm ihzeTul,ihH aiaelkn aHrdri audG eprGyoeraUw ouetnwotOht,o ihha cshCsiba,Yy ro itcehGire a nnde R NeNacokeTbarpunatyinuosskhrfii e r inHtaoofr aa aa
Hitoshi Kohno, and Naofumi Nagasue
cdr2, a Target Antigen of Naturally Occurring Human Tumor Immunity, is
ification of a G Dimer That Induces the Selective Degra- Widely Expressed in Gynecological Tumors. Jennifer C. Darnell, Matthew PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial
dation of HER-Family Tyrosine Kinases. Fuzhong F. Zheng, Scott D. L. Albert, and Robert B. Darnell Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial
Kuduk, Gabriela Chiosis, Pamela N. Minster, Laura Sepp-Lorenzino, Samuel Growth Factor-induced Responses and Tumor Growth after — Administra
J. Danishefsky, and Neal Rosen tion. Jeanette M. Wood, Guido Bold, Elizabeth Buchd
WWOKX, a Novel WW Domain-containing Protein Mapping to Human Ferrari, Jérg Frei, Francesec
Regulation of TCL1 Expression in B- and T-Cell Lymphomas and Reactive Chromosome 16q23.3-24.1, a Region Frequently Affected in Breast Cancer. e O'Reilly, Elke Persohn
Lymphoid Tissues. Maria Grazia Narducci, Edoardo Pescarmona, Cristina Andrzej} K. Bednarek, Kendra J. Laflin, Rachael L. Daniel, Qiaoyin Liac Andreas
CLaazrzleor i, DaSvaibidn a BSairgonnoir,e tti, AntAonnneal la MariSat opLpaavcicniiaar,o , DaniCealrel o RemMoattrii,a EnCrroicceo, Scaalnad, Kathleen A. Hawkins, and C. Marcelo Aldaz MMeanrrtaidn, R. GSecrhhnaeridde r, Joachim Drevs, Georg Martiny-Baror
Giandomenico Russo and Dieter Marmé
CCAyhbcoeulm-ooIospsxraye,g veenanantsdi eo Kna 2r enI nohfSi ebiibteoBrrrt.e astR andalCla ncEe. r Harriisn, GRaaltasl A.b y AlsChaeflieec,o xiHbu,s seina Regular Articles GSyrnoewrtghy. bYeut weenY okAonygaiomsat,a tinM ohaanndr ajE ndoDshtaanatbianl:, InAhrijbaint ioWn. oGfr Ovara ian VikCaasn cePr
Sukhatme, and S. Ramaknshnan
U0126 Reverses Ki-ras-mediated Transformation by Blocking Both Mito- Biochemistry and Biophysics
gen-activated Protein Kinase and p70 S6 Kinase Pathways. Hidesuke Expression of Proteins Coincident with Inducible Radioprotection in Hu-
Fukazawa and Yoshimasa Uehara. man Lung Epithelial Cells. Simon C. Gamble, Michael J. Dunn, Colin H Epidermal Growth Factor-mediated ee of Chiorin eg Selectively Poten-
TDhNeA RaDdaim age Citihzieng ckpoAignetn t Ki7n-aHsyed hChk1. EricPks a C. B(usUbCyN, -01D)ru IFn. hiLbeiitsst rittzh,e Wheeler, Michael C. Joiner. Anita Adu-Poku, and Janet E. Arrand. tiates Its Phoatndo dPyentearm ic Activity. Antoon Gijsens. Ludwig Missiaen, W
Robert T. Abraham, Larry M. Karnitz, and Jann N. Sarkaria
Atterations of the INK4a/ARF Locus in Human Intracranial Germ Cell Clinical investigations E-7869 (R-Flurbiprofen) Inhibits Progression of Prostate Cancer in the
Tumors. Masayuki [wato, Osamu Tachibana, Yasuo Tohma, Yasuaki Prognosis of Primary Testicular Seminoma: A Report on 57 New Cases. TRAMP Mouse. William J. Wechter, Douglas D. Leipold, E. David Murray
Arakawa, Hisashi Nitta, Mitsuhiro Hasegawa, Junkoh Yamashita, and Yutaka Keita Fujikawa, Yoshiyuki Matsui, Hiroya Oka, Shigeki Fukuzawa, Miharu Jr. David Qui John D. McCracken, Robert S. Barrios, and Norman M
Hayashi Sasaki, and Hideo Takeuchi Greenberg
vi
CONTENTS OF VOLUME 60
Immunology Molecular Markers in Blood as Surrogate Prognostic Indicators of Mela- Human Glioblastoma Cell Lines: Levels of Low-Density Lipoprotein Recep-
noma Recurrence. Dave S. B. Hoon, Peter Bostick, Christine Kuo, Tetsuro tor and Low-Density Lipoprotein Receptor-related Protein. Lenka
CwtoiC t hD CrAhapeionmpiotnkogti ince L TyuRmempcoher p toCNreo-ldl7es s:. o nCr MiDtoeitcnoadhlri irtRoio cl e HCiiernla loMs,i gIrsNa otIbinuodynuu ckefidr omaO fnttaehire, TInuKtmaeozrraucm taSisiotane Okamoto, He-Jing Wang, Robert Elashoff, and Donald L. Morton LMaaulreat inJs.k 4K,n offE,l eaannodr TrAu.d y BlMa.k elFyo,r te Kathleen A. Bjornstad, Dennis F. Deen,
Hiroishi, Simon C. Watkins, Kouji Matsushima, Paul D. Robbins, Michael T Dihydrotestosterone as a Selective Cellular/Nuclear Localization Vector for
Lotze, and Hideaki Tahara Anti-Gene Peptide Nucleic Acid in Prostatic Carcinoma Cells. Lidia C
Boffa, Sonia Scarfi’, Maria Rita Mariani, Gianluca Damonte, Vincent G.
Immune Deviation and Fas-mediated Deletion Limit Antitumor Activity Allfrey, Umberto Benatti, and Patricia L. Morris.
after Multiple Dendritic Cell Vaccinations in Mice. Antoni Ribas, Lisa H Apoptosis Is Induced by the Active Metabolite of Vitamin D3 and Its
MBKucathBtlreiirldf ei,eJ. l d,Aa nnddBr ielJwlasym ,e sH uM,aS .g gVEiicevo inaLnoe meo, Bu. SarDails seNt.t e, AmaWri,l soJno hnS . A. MeGnlga,s py,A ndWrielwl iamK ohH, IrKnorsnzuayllsi znt-oHlf1i k9e-R 7ei Gsrs,oC ewltlBsha. r baFAranacd troeVraa leIn MtRoierncrieis,op nteoM,ri chSGaiaegelnt aalniDone wgs ,Ri on mEaDvinafo f,e ErveenMsta,ig aatlMiiao rns hNoaaf v aNrReriuoc,-h AIPamnrpaallsiokcgeavutaei, o nEsM Bi1ke0f 8o9rG . iTPnhr oeCmvoaelsno,tr ieocLnti asle aBAniddn edenroTumph,ae r aapanynd. d AnCGg.a erlcai DanHroaimgoua e . DCiealzl,s : PCohsrsiisbtloes
Rosner, and Renato Baserga.
Molecular Biology and Genetics
AMSH6 Alterations in Patients with Microsatellite Instability-Low Colorec- Enhanced Sensitivity to i-B diol. ide DNA Damage Announcements
tal Cancer. Yann R. Parc, Kevin C. Halling, Liang Wang, Eric R Correlates with Decreased Global Genomic Repair ‘Attributable to Abro- Future Annual Meetings of the American
Christensen, Julie M. Cunningham, Amy J. French, Lawrence J. Burgart gated p53 Function in Human Cells. Manzoor A. Wani, Qianzheng Zhu, Association for Cancer Research
Tammy L. Price-Troska, Patrick C. Roche, and Stephen N. Thibodeau. Mohammed El-Mahdy, Sundaresan Venkatachalam, and Altaf A. Wani Workshop on Pathobiology of Cancer
KLKiawtnahknei,rn ign eX GieaJ.no ehM oanrEtgxi pnr, eZshBsarinigoa,nn PMA.al tatnKe rrintsMz amctaokn a,T yh,eL raaurpMaie cuhtMai.e cl PrGircJo.e ,u pOBs'rH iaairnne ,B KroehaC,sa tr ColhCyian-n PcoenrM.g Tumor Biology WWoorrCklkissnhhioocappl ooOnnn cMMooelltoehgcoyud lsa r in BiCloilnoigcya l inC ancer
Kaelin, George L. Mutter, Arthur B. Pardee, and Ruth Sager. Thioredoxin Reductase, a Redox-active Selenoprotein, Is Secreted by Nor- Research
mal and Neoplastic Cells: Presence in Human Plasma. Anita Séderberg, AACR Special Conferences in Cancer
The Normai patched Allele is Expressed in Medulloblastomas from Mice Bita Sahaf, and Anders Rosén. Research
with Heterozygous Germ-Line Mutation of patched. Cynthia Wetmore, Recent Deaths
Derek E. Eberhart, and Tom Curran. Calendar of Events
Interleukin 8 Expression Regulates Tumorigenicity and Metastasis in Hu-
2247 Ubiquitin/Proteasome Pathway Regulates Levels of Retinoic Acid Receptor man Bladder Cancer. Keiji Inoue, Joel W. Slaton, Sun Jin Kim, Paul
y and Retinoid X Receptor a@ in Human Keratinocytes. Mohamed Perrotte, Beryl Y. Eve, Menashe Bar-Eli, Robert Radinsky, and Colin P. N
Boudjelal, Zengquan Wang, John J.V oorhees, and Gary J. Fisher. Dinney Author Index
May 1, Number 9
Advances in Brief Tumor Necrosis Factor-related Apoptosis-inducing _Ligand- Microsatellite Instability at Selected Tetranucleotide Repeats Is Associated
mediated Apoptosis in Androgen-independent Prostate Cancer Cells. with p53 Mutations in Non-Small Cell Lung Cancer. Steven A. Ahrendt, P.
2317 LMiugtaanndt RAensdproonsgievne neRsesc epitn orHsu mafnro m ProLsNtCataeP Caanncde r:C WSRt2ru2c turTaulm orAsn.al ysiSsh awonf AR-oNn.g TonyYu , KongS andhya Mandlekar, Steve Ruben, Jian Ni, and JAinnt hJoenn,y anDde ckDearv,i d KaSriad raDnoskfyf.e k, Benny Wang, Lihua Xu, Michael J. Demeure,
McDonald, Lars Brive, David B. Agus, Howard I. Scher, and Kathryn R. Ely
Carcinogenesis Genetic Instability and Hematologic Disease Risk in Werner Syndrome
Patients and Heterozygotes. Michael J. Moser, William L. Bigbee, Stephen
eager Chemoresistance to 7-Ethyl-10-[4-(1-piperidino)-1- Identification of the Messenger RNA for Human Cutaneous Fatty Acid G. Grant, Mary J. Emond, Richard G. Langlois, Ronald H. Jensen, Junko
hecin (CPT-11) in Colorectal Cancer binding Protein as a Metastasis Inducer. Chun Jing, Carol Beesley, Oshima, and Raymond J. Monnat, Jr.
Cells and a Xenograft Model Is Overcome by Inhibition of Nuclear Christopher S. Foster, Philip S. Rudland, Hiroshi Fujii, Terno Ono, Haijuan
Factor-xB Activation. James C. Cusack, Jr., Rong Liu, and Albert S Chen, Paul H. Smith, and Yougiang Ke.
Baldwin, Jr Tumor Biology
NBoidjimeesg eann dB rMeeaikoatgice STeylnodmreormese. DiDsaevaisde BP.r oLteoimnb aarndd aMnRd E1Le1o naartd PMGuLa reNnutcel ear SmUpraosrroynl ,i c EapnAidct ihAednl idaIrlne hwi bCieJtl.ls s D.a CnynKcoeltnohbaoe xrygSg uebnbaasrea-ma2i ahT,r anPsecdrriop tiMoicnh aliuna rHt,u maMinc haMela m-B. GTRruoolmdeoz rison.fs kyE,xPa toralanocd e llRAu.a lkaersN het MtiaK,.t riJaDxia nv. iAds seAm.b lyB erikn, InMteerlsotdiyti al A.T raSnwsaprotzr,t iAnl aSno lidJ .
APMkooallseyacmkuealr,aa rs e MAansaCathyaouikmniy oRfKe uarBacCttaLi,6o n-bTCarhsaienydso lkooc aAtsisUoaenydssa ., RHeivrAeokasilhriea d AbSkyhai smaLikzoaun,,g -DiTTsaatkkaaansschheii SIkneclreetaasle d MuGsecnlee EUxCprPe2s sEiaonnndd oofUc CBrPri3o nwnoi nl FoaMtgA CyU1 n6c-oiunpdluincge d ProCtaenicne r( UCCPa)c1he xiaan.d JAPer fifCrmreaiyrt iycE .a lT SuemSgoatlrelp. iJne ffMreetya stBa. siWsy:c koJfnf , VivJoo an AnGa. lysJoinse s, ofJ oIhnnt raS.v aCsoantdieoenl isa,t atnhde
Uchiyama, and Hitoshi Ohno. Chen Bing, Michael Brown, Peter King, Peter Collins, Michael J. Tisdale, and
Gareth Williams. A Spontaneous Murine Melanoma Lung Metastasis Comprised of Host x
Tumor Hybrids. Ashok K. Chakraborty, Stefano Sodi, Michael Rachkovsky,
The Fhit Tumor Suppressor Protein Regulates the Intracellular Concen- Natalia Kolesnikova, James T. Platt, Jean L. Bolognia, and John M. Pawelek.
tration of Di: Trip but not Tetraphos- Epidemiology and Prevention
phate. Gillian A.M urphy Deborah Halliday, and Alexander G.M cLennan. Functional Assay for BRCA1: Mutagenesis of the COOH-Terminal Region Anti-angiogenic Cues from Vascular Basement Membrane Collagen.
Reveals Critical Residues for Transcription Activation. Finbarr Hayes, Pablo C. Colorado, Adriana Torre, George Kamphaus, Yohei Maeshima,
Specific c-kit Mutations in Sinonasal Natural Killer/T-Cell Lymphoma in Charmagne Cayanan, Daniela Barilla, and Alvaro N. A. Monteiro. Helmut Hopfer, Keiko Takahashi, Ruediger Volk, Eric D. Zamborsky, Seth
China and Japan. Tadashi Hongyo, Ting Li, Mukh Syaifudin, Rajamanickam Herman, Pradip K. Sarkar, Mark B. Ericksen, Mohanraj Dhanabal, Michael
BNaosmkuarra,. Hirokazu Ikeda, Yuzuru Kanakura, Katsuyuki Aozasa, and Taisei Experimental Therapeutics SSiumkohnast,m e, Maarnkd RPaogsth,u DKoalnlaulrdi W. Kufe, Ralph R. Weichselbaum, Vikas P.
Flavopiridol Binds to Duplex DNA. Keith C. Bible, Roy H. Bible, Jr.,
Progesterone Receptor Gene Polymorphism Is Associated with Decreased Timothy J. Kottke, Phyllis A. Svingen, Kun Xu, Yuan-Ping Pang, Elisabeth Human Myeloid and Lymphoid Malignancies in the Non-Obese Diabetic/
Risk for Breast Cancer by Age 50. Shan Wang-Gohrke, Jenny Chang- Hajdu, and Scott H. Kaufmann. Severe Combined Immunodeficiency Mouse Model: Frequency of Apoptotic
Claude, Heiko Becher, Dirk G. Kieback, and Ingo B. Runnebaum. Cells in Solid Tumors and Efficiency and Speed of Engraftment Correlate
Proteasome Inhibition Circumvents Solid Tumor Resistance to Topoisomer- with Vascular Endothelial Growth Factor Production. Lisa Fusetti,
ase II-directed Drugs. Yasunari Ogiso, Akihiro Tomida, Shuhong Lei, Giancarlo Pruneri, Alberto Gobbi, Cristina Rabascio, Nadia Carboni, Fedro
Kinetics of Plasma Epstein-Barr Virus DNA during Radiation Therapy for Satoshi Omura, and Takashi Tsuruo. Peccatori, Giovanni Martinelli, and Francesco Bertolini
Nasopharyngeal Carcinoma. Y. M. Dennis Lo, Sing-Fai Leung, Lisa Y. S.
CHhuaann,g Anthony T. C. Chan, Kwok-Wai Lo, Philip J. Johnson, and Dolly P. immunology NCI-H460-LNM3an5d wCi!t h Consisti ent Lymofp h2o gHeunmoauns MLeutnagst aCsiasn cevira BCoetlhl SLuibn-e
ification of Diff ial of the WTI Antisense Regulatory IHmummuanni tyB retaos tM urCiannec erB reAanstti geCna,n ceirn TCrealnlss geMnoidci fiMeidc e toT oElxeprraensts tMo UCH-u1m,a n a cTeuttsaunyeao usT suaknadm otOor,t hotYoosphiico PTraotpeamgaattsui,o n. ToKyeona-kiic hi HidKao,z akTio,s hiOtsaadma u TaMkiayhaaisshhii,,
Region and Relaxation of Imprinting in Wilms’ Tumor. Karim Malik, MUC-1. Victoria Carr-Brendel, Dubravka Markovic, Karen Ferrer, Michael and Takashi Takahashi
Ashreena Salpekar, Anne Hancock, Kim Moorwood, Sally Jackson, Adrian Smith, Joyce Taylor-Papadimitriou, and Edward P. Cohen.
CtThihavera lteiRsoa,ns -aMonifd t oMKgaeetinrt-hia xc Wt. iMveaBtrtaoelwdln o. pPrrootteeiinna sKei naSseec rePtaitohn wayan d Is tChrei tiIcnavl asfiovre ntehses Aci-n GCFMoroosemuteebsnrieb,n eargtME,iou odgneeM nlaue Ir miUcmsDeu.i nnoBg.t K hwBCoeuTnrr,Lga ,Ap -yaT4 na dno f JBPalTrmoreciuskmo aandrgPe.y,. AlPlEAriruostsgohtneu.an rte e AC.M a.n cHueCrrhw oiiti,zn , a NToBrarrambnaasnrg ae niMAc TCLE..oe cmGaSptrcoiohromoainmld ,t ,DP eArpnNoneag nnrdceFyse. snCichoKeane rm kboovefflr i seMMt,ee, tt aaassKnttidaas sthiiIosacrn e iCIn.n V e.L fMufaniNcgcaDi:doek nnacCaryeln.ldi l,. MS.uV rivnDiciveaanlnt,n e DL.oC raMmmoaerrnroicsny,,, AaElrnaidnc
v-crk-transformed 3Y1. Enbo Liu, Aye Aye Thant, Fumitaka Kikkawa,
Hisashi Kurata, Shinya Tanaka, Akihiro Nawa, Shigehiko Mizutani, Satoru Cytokine Gene Therapy of Gliomas: Induction of Reactive CD4* T Cells by Acquisition of Chemoresistant Phenotype by Overexpression of the Anti-
Matsuda, Hidesaburo Hanafusa, and Michinari Hamaguchi i 4 sfected 9L Gli Is Essential for Protective Immu- apoptotic Gene Testosterone-repressed Prostate Message-2 in Prostate Can-
nity. Katinka M. Giezeman-Smits, Hideho Okada, Cynthia S. Brissette- cer Xenograft Models. Hideaki Miyake, Colleen Nelson, Paul S. Rennie, and
Levels of E2F-1 Expression Are Higher in Lung Metastasis of Colon Cancer Storkus, Lorissa A. Villa, Jason Attanucci, Michael T. Lotze, lan F. Pollack, Martin E. Gleave.
As Compared with Hepatic Metastasis and Correlate with Levels of Thy- Michael E. Bozik, and William H. Chambers.
midylate Synthase. Debabrata Banerjee, Richard Gorlick, Anna Liefshitz, Aspirin Inhibits Tumor Cell Invasiveness Induced by Epstein-Barr Virus
SKuartehsyh DJahnaennwbaerr,g , CaPreltoesr CC.o rDdaonne-nCbaerrdgo,, PeYtuemr anV. FDoannge,n beNragn,c y DavKiedm enKyli,m straan,d Molecular Biology and Genetics aLsaet-e9n t EMxpermebsrsiaonne. PSrhoitgeeiynu ki1 thMruoruognho , SupTporemsosikoan zu ofY oMsahtirzaikxi , Hiroshi Sato,
Joseph R. Bertino. Photorepair Prevents Ultraviolet-induced Apoptosis in Human Cells Ex- Hajime Takeshita, Mitsuru Furukawa, and Joseph S. Pagano.
— the Marsupial Photolyase Gene. Vanessa Chigangas, Eliane Namie
fiIMennor anactsKtse-ie rrvarabsaty ti oPnir nSo oamfnoC ctothelheeorz r -eDCHcNetysAappl ee rdRmeeTesput,am hioyrrlG iaagGbtereiinnoeeenls i0sIC.s.a pAesMlsaloanc,ei la tMeidEg suteewlliil tenhre ,A- nGDg NeMAtli o n orAP ueMi unatdTaoot,yi ootnaDs,. AsMPicey sraRsjiiiop,nl tiei onAfamoAlrla yrtsaAhsnceott niep v-3aM8teR ienoMndniae ttsoo,o g fe nAMp-kua5ioc3rtt arii o,vnY a atseJuGdaie, cn qouPaternolodixt neieiCc na r ldSKoetis rn easFFssrae et dibemPryaai tcCoh JhwaeaMcmyayor sttyiinhnn,e s rt haeGMp euenTsucrttkaa.inv c-o CtFRhaaoertnlisicdca uhlre Mkro,eCi ennlftala nsrd ,a noFdfaY tatnIMa nandeGmheam poea An.rd MyeaT nna,vta CsasLGoraelucnirie etnniotcm aA:Ar lntoeurladt,i onGsa ryi n La. rpSo r t rTos mayl aMnadn fErpeid-
Neil Watkins, Jean-Pierre J. Issa, David Sidransky, Stephen B. Baylin, and Agents. Ricardo Sanchez-Prieto, Jose M. Rojas, Yoichi Taya, and J. Silvio
James G. Herman. Gutkind.
Announcements
WiHtuRyi NiC nh eoTnrr ,a TneMsl.f oomSretmreeapdsh ee nW CeoMrnensyetnrr,u cJtSusyn nkdoR ervoOemsrhesi em aF,4i -brNaoinbtdlr aosSqtuhsie.nr omlaFinunk ei M.1M .- OWxeHiiidssesa mmSaae,nn siYtaiov-- PCMPearatroneggcrare rerAes..ts iJvCoAaen.r e osl.IK nncorwSelaaelsesem,s, AinnG -adCnehg enNnio nvgoF engML,ei atnhSgyu,ls aatnY ivoGonrn onsoehf e nC,Cp .G P eTtseIarsi l,a Wn.d sJ aNnieicn h oBlClso,au ldtdeaernr,d FWWuootrrAukkrssess ohhcooAippna ntuiooaonnln PMfMaooetlrhee otcCbuiailnnoagclrseo rg oyBf iR oetolshfoee ga CyrAa cmnhiec ner ri can
Clinical Oncology
Regular Articles AllelicL oss at reaSpi otui si n Polyps sh vege PolyposiCsl oPnaatli enOtrsi gainnd oUfs e thoef WorRkessehaorpc h on Methods in Clinical Cancer
Epithelium. Kelly Wexthebtuhen, Jill Williamson, Stephen Bevan, AACR Special Conferences in Cancer
Joanne Young, Barbara Leggett, lan Frayling, Yi Thway, Shirley Hodgson, Jin Research
Biochemistry and Biophysics Cheon Kim, Takeo Iwama, Marco Novelli, Denise Sheer, Richard Poulsom, Recent Deaths
2377 Nitric Oxide Inhibits Apoptosis via AP-1-dependent CD95L Transactiva- Nicholas Wright, Richard Houlston, and lan Tomlinson. Calendar of Events
tion. Gerry Melino, Francesca Bernassola, Maria Valeria Catani, Antonello Genome-wide Screen for Allelic Imbalance in a Mouse Model for Neuro-
Rossi, Marco Corazzari, Stefania Sabatini, Francis Vilbois, and Douglas R blastoma. William A. Weiss, Tony Godfrey, Carla Francisco, and J. Michael
Green. Bishop. 2569 Author index
Vii
CONTENTS OF VOLUME 60
May 15, Number 10
Perspectives in Cancer Research Clinical Investigations 2710 Cooperativity of Staphylococcal aureus Enterotoxin B Superantigen, Major
LIomllmiunin, opPrieervoe ntMuisoiann i, of anCda ncMearr:i o IsP. theC olToimbmoe Ripe? Guido Forni, Pier Luigi 2632 iCnl inUitcearli neI mplCiecravtiicoanls Coafn cEexrpsr. essJiiroo n Foufj iImonttoe,r leuHkiidne-k8i RSealkaatgeudc hit,o Aknguimoig eneAsokiis HvBMurialesnlatcesoret,cd o mCpSaaanptndo icnbeStirual zniatenMyono eud se lO.CsM toerm tpalsexti ha sCeAl.s a ssii nP ulaa[ 1s,kC lainndic allyC D80RS elfeovr anIt mu m—unoth eraKp y oMfo usAde-
Advances in Brief Experimental Therapeutics
Depletion of Tumor Oxygenation during Photodynamic Therapy: Detection Molecular Biology and Genetics
Effects of the Multidrug Transporter P-Glycoprotein on Cellular Responses by the Hypoxia Marker EF3 [(2-Nitroimidazol-1{H}-yl)-N-~ 3-trifluoro-
to Ionizing Radiation. Adam C. Ruth and Igor B. Roninson propyl)acetamide]. Theresa M. Busch, Stephen M. Hahn, Sy M. Evar Comparison of TP53 Mutations Identified by Oligonucleotide Microarray
and Cameron J. Koch and Conventional DNA Sequence Analysis. Wen-H n
Influence of Nitric Oxide Synthase II Gene Disruption on Tumor Growth and
Metastasis. Qian Shi, Qinghua Xiong, Bailiang Wang, Xiangdong Le, Nasim Fas-dependent and -independent Mechanisms of Cell Death following DNA M
A. Khan, and Keping Xic Damage in Human Colon Carcinoma Cells. Istvan Petak. David M
Till unklin G. Harw 1, Rudolf Mihalik, and Janet A. He hton
Effects of Thomsen-Friedenreich Antigen-specific Peptide P-30 on B-Galac-
toside-mediated Homotypic Aggregation and Adhesion to the Endotheli Induction of Apoptosis in Leukemic Cells by the Reversible Microtubule- Cytoplasmic Sequestration and Functional Repression of p53 in the Mam-
of MDA-MB-435 Human Breast Carcinoma Cells. Vladislav V. Glins' disrupting Agent 2-Methoxy-5-(2’,3'.4’-trimethoxyphenyl)-2,4,6-cyclohep- mary Epithelium Is Reversed by Hormonal Treatment
Margaret E. Huflejt, Gennadi V. Glinsky, Susan I Deutscher, and Thomas P tatrien-l-one: Protection by Bel-2 and Bel-Xyj and Cell Cycle Arrest
Quinn Consu yajal abel Barasoain, José M. Andreu, and Faustino Mollined:
Breast Cancer Resistance Protein Is Localized at the Plasma Membrane in Liposome-delivered Angiostatin Strongly Inhibits Tumor Growth and Met-
Mitoxantrone- and Topotecan-resi Cell Lines. George L. Scheffer astatization in a —— Model of Spontaneous Breast Cancer. Mania
MMaarrei skaM alCi. epdaea rdJ,o ng, AdArnioaunka BC.. LS chroeijePrisj,n enbDoorrgi,n a MMa. rgévatn deA.r Kvoalnk , GaJsothenl enD vio EAdnorrincia, MLiuriagi ¢ Zec Tumor Biology
Allen, Douglas D. Ross, Paul van der Valk, William S. Dalton, Jan H.M Small Cell Lung Carcinoma Exhibits Greater Phospholipase C-61 Expres
Schellens, and Rik J. Scheper sion and Edelfosine Resistance ( oe with Non-Small Cell Lung Car
Efficient Induction of Cell Death by Adenoviruses —— oe of cinoma. Derek S S H. S {
Estradiol Induces Functional Inactivation of p53 by Intracellular Redistri- E1B55k and p53. | R. Dix, Simon J. O' Carroll, Colle M J W
bution. Anna Maria Molinari, Paola Bontempo, Etto Schiavone W. Braithwaite
Vincenzo Tortora, M. Antonietta Verdicchio, Massimo Napolitano, Emest
Nola, Bruno Moncharmont, Nicola Medici, Vincenzo Nigro, Ignazio Armetta. Two Novel 14-Epi-Analogues of 1,25-Dihydroxyvitamin D3 Inhibit the
CMiornoo alAlbebloincd anzAam,p liafnidc atGiioonv anonfi EAs.t rPougcean Receptor-a Expression in Breast GVrero wth of Hnuemm an BVreerassttuy f, CanMcaerrk CeVlanl s MaCiaunmr pi,t sV iSturzo and Mairne Vivo. | itIodnredynu cceiL bolooep f. apRp bR2Cba/n2dpa/c1pe 3103 0M,.E xppHr 2e7ss%iioPn! aanndd GCryocwltihn -sEu ppNregeastsiivvee FMeeecdhbaanciks msR:e gulEay-
Cancer. Eric R. Schuur and Ronald J. Weigel
PPMAi.a l nlNcaLsorecverheac, lht, i cB TeGaurtCiaaadn nosc mBeureAr.dmgl hbearrC,r hadrtni,sea tn idn eST TaehkreoiWsnmahelai ls r aPpIrMpw.o,a t meuGarrsSaeeus,s s a n(nMTea MnPuRHeaSlh Sne3lR),u theOFnrvbiieeirdreegrxeirpk,re essMMeiaidrl kleursi n mMTaorruaysn esf eCraMarsacemi mnaoImrnhnaynise brb ,iu trgoTeTrrHuh.,oa m two arr CCdhaa VnHei marY u.Bse B- Ah.KC ihiGem-nrOn,rm oaeawtrstMh,Bhw y a-mliaanZT ,hur inabxniustgaeeMnand ric cC hbeyn M,i ac e FRoaSDnrheanovlebdesh lynolap:E . P rGoMDotiapeeamhil-ln Virology
RESaxencpciaasirir o n Syosft emT.a moSxhiinfyea n-SDhiNbAu taniA,d duJcotysc e byT tRheea rdHonu,m anNa omNiu clSeuoztuikid,e Eaxndc isAizoinz MAElolsisst, ridJM a.ck sKroarlmn, B.D ongGJmi. ibnbgnOs d', N eLNililala,nnu c,yGrE E e Re r GiUM.nen gni eqM.uGi eadds etAlrxTdiero cra pn.s cAurr diepnHti Cohirc oanr ciPnatotm4M earsMn: of EExppsrt\e esisni-oP.B na rBrro ifn k.V tihreu sM ikT r(aEBnVs) forimn inEgB V-cBaArRrFy/
Radiation and the Apo2L/TRAIL Apoptotic Pathway Preferentially Inhibit Recombinant Adenovirus Vaccine Encoding a Chimeric T-Cell Antigen
the Colonization of Premalignant Human Breast Cells Overexpressing Cy- — Induces Protective Immunity against a T-Cell Lymphoma.
clin D1. Qun Zhou, Paula Fukushima, William DeGraff, James B. Mitchell Ww and Ronald L 2749 Announcements
Maryalice Stetler-Stevenson, Avi Ashkenazi, and Patricia S. Steeg al M
Methioninase Gene Therapy of Human Cancer Cells Is Synergistic with
Recombinant Methioninase Treatment. Kenji
Regular Articles Mingxu Xu, Ping Jiang. Yuying Tan, Michael B:
Gupta, Takashi Chishima, Hiroshi Shimada, Masatoshi Mala kuuchi
M sa, and Robert M
Biochemistry and Biophysics
p16NK4A Mediates Cyclin Dependent Kinase 4 and 6 Inhibition in Senes- Immunology
cent Prostatic Epithelial Cells. Charanjit Sandhu, Donna M. Peehl, and 2703 Endogenous Interleukin-18 Modulates Immune Escape of Murine Mela-
Joyce Slingerland noma Cells by Regulating the Expression of Fas Ligand and Reactive
Oxygen Intermediates. Dacho Cho, Hyunkeun Song, Yong Man Kim, Di
High and Low Fluences of a-Particles Induce a Gy Checkpoint in Human Houh, Dae Young Hur, Hyunjeong Park, Doyoung Yoon. ‘ Ho P.
Diploid Fibroblasts. Edouard | Azzam, Sonia M. de T Anthony J Wang Jae Lee, Masashi Kurimoto, Yoon Berm Kim
Waker, and John B. Little. Author Index
June 1, Number 11
Advances in Brief Expression of a Repressor of Estrogen Receptor Activity in Human Breast 2845 RET a Expression in Thyroid Follicular cee: — derived
Tumors: Relationship to Some Known Prognostic mesa Sharon L. R Tamers. Giuseppe E Ma g
a Parkes nne Leygue, Helmut [ L Ja Snell, Sandra
p53 Polymorphism in Human Papillomavirus-associated Esophageal Can- Mua rphy
cer. Hidetoshi Kawaguchi, Shinji Ohno, Koshi Araki, Mitsuhiro Miyazaki
Hiroshi Saeki, Masayuki Watanabe, Shinji Tanaka, and Keizo Sugimachi
Aloe-emodin Is a New Type of Anticancer Agent with Selective Activity Regular
against Neuroectodermal Tumors. Teresa Pecere, M. Vittoria Gazzola, Carla
Amplification in Human Breast Cancer of a Gene Encoding a c-myc mRNA- Mucigna tina Parolin, Francesca Dalla Vecchia, Andrea Cavaggioni
binding Protein. Glenn A. Doyle, Jeanne M. Bourdeau-Heller Stephanie Modesto Carli, and
Coulthard, Lorraine F. Meisner, and Jeffrey Ross. Biochemistry and Biophysics
Prostate Adenocarcinoma Cells Release the Novel Proinflammatory
2760 Detection of Exon Deletions and Duplications of the Mismatch Repair Genes in A Novel Antisense Oligonucleotide Targeting Survivin Expression Induces Ap- Polypeptide EMAP-II in Response to Stress. Geor mmett, Anne-M
Hereditary Nonpolyposis Colorectal Cancer Families Using Multiplex Polym- optests and Sensitizes Lung Cancer Cells to Chemotherapy. Robert A. Ollie akobsen, Maart Tas, Katherine Ric ui rs
erase Chain Reaction of Short Fluorescent Fragments. Francoise Chart \ 2 Simdes-Wiist, Bettina Baumann, Sian H. Leech, Doriano Fabbro, Rolf Murray
Grégory Raux, Qing Wang, Nathalie Drouot, Frédénc Cordier yemeister-W ittke
Limacher, Jean-Christophe Saurin, Alain Puisieux, Sylviane Olschwang, and
Thierry Frebourg Peripheral Tolerance to Human Papillomavirus E7 Oncoprotein Occurs by Carcinogenesis
Cross-Tolerization, Is Largely Th-2-independent, and Is Broken by Den- Impact of Global Genome Repair versus Transcription-coupled Repair on
Functional Evidence for a Novel Human Breast Carcinoma Metastasis Sup- dritic Cell Immunization. Tracy Doan, Karen A. Herd, Paul F Lambert Ultraviolet Concineguets in Hairless Mice. Rob Ww
pressor, BRMS/, Encoded at Chromosome 11q13. M. Jabed Seraj, Rajeev S. Germain J. P. Fernando, Michael D. Street, and Robert W. Tindle
Samant, Michael F. Verderame, and Danny R. Welch
The von Hippel-Lindau Tumor Suppressor Targets to Mitochondria. Yih
2770 Telomere Erosion Varies during in Vitro Aging of Normal Human Fibro- Horng Shia James H. Resau, Kunio Nagashima, Lucy M. Anderson, and B-Catenin Mutations and Protein Accumulation in All Hepatoblastomas
blasts from Young and Adult Donors. Reyne! Figueroa, Heike Lindenmaier Gayatri Ramakrishna. Examined from B6C3F1 Mice Treated with tenes or ae
Manfred Hergenhahn, Kirsten Vang Nielsen, and Petra Boukamp. H. Anna, Robert C.S ills, Julie F.1 vy.P atricia S. Stoc a
Role of the von Hippel-Lindau Tumor Suppressor Protein during Neuronal
2775 Deletion of 6q16-q21 in Human Lymphoid Malignanci: A Mapping and Differentiation. Hiroshi Kanno, Farid Saljooq Yamamot
Deletion Analysis. Amanda Jackson, Paola Carrara, Veronique Duke, Paul Hattori, Masahiro Yao, Taro Shuin, and Hoi-San; Retinoic Acid Receptor and Retinoid X Receptor Alterations in Lung Can-
Sinclair, Mary Papaioannou, Christine J. Harrison, and Letizia Foroni cer Precursor Lesions. Nadine Martinet Alla, Guillaw
2780 pDrifefsesrieonnt ialb y SuEscxeopgteinbioluist y Fohfi t RenEaxlp reCsasriocni.n omNai colCee ll SuLsiannens toW erTneurm,o r ZSuurapb- ITnrtaeRnr saaccttiiovna tbieont weoefn a SpDi!f faenrde ntCieallt ioCny-crleel atReedg ulGaetnoer.y OPlriovteeri nsG. IsO pIimtzp oratnad nt Aniiln GTTaaauhobane f.i Bkaaz DaarLnbaiabecilhbli,e, HLéJleeéa nnFe-a Moui,cD rhoeuloJ toé,l Vlie gRneaSyui adt.n, a ld Jaar cV Picard.
Siprashvili, Louise Y. Y. Fong, Guido Marquitan, Jan K. Schrider, Walter
Bardenheuer, Siegfried Seeber, Kay Huebner, Jochen Schiitte. and Bertram Loss of p53 in Benzene-induced Thymic Lymphomas in p53+/— Mice: Genetic Resistance to Chemical Carcinogen-induced Preneoplastic bog aa
Opalka Evidence of Chromosomal Recombination. Scott E. Boley. Elizabeth E Lesions in DRH Strain Rats.
Anderson, John E. French, Lawr Dana B. Walker, and Kitayama, Ay umi Dend:
Hiai, and Ken Higashi
Translocation t(10;14)(q11.2;q22.1) Fusing the Kinectin to the RET Gene
Creates a Novel Rearranged Form (PTC8) of the RET Proto-Oncogene in
Radiation-induced Childhood Papillary Thyroid Carcinoma. Konstadinos A Region of Deletion on Chromosome 22q13 Is Common to Human Breast In Vitro and in Vivo Studies of Methylseleninic Acid: Evidence That a
Salassidis, Jochen Bruch, Horst Zitzelsberge: Edmund Lengfelder Albrecht and Coléiccial Cancers. Antoni Castells, James F. Gusella, Vijaya Ramesh Monomethylated Selenium Metabolite Is Critical for Cancer ( Reneepeeven-
M. Kellerer, and Manfred Bauchinger and Anil K. Rustgi tion. Clement Ip. Henry J. Thompson, Zongjian Zhu. and Howard E. Ganther
2790 Oncolysis of Diffuse augue Carcinoma by Intravascular Adminis- Expression of Bone Morphogenetic Protein Receptors Type-IA, -IB, and -II Sex Differences in the Activation of Tamoxifen to DNA Binding Species in Rat
tration of a . Genetically gi Correlates with Tumor Grade in Human Prostate Cancer Tissues. Isaac Liver in Vivo and in Rat Hepatocytes in Vitro: Role of Sulfotransferase Induc-
Timothy M. Pawlik, Hideo Nakamura, Sam S. Yoon, John Yi Kim, Dong-Hyeon Lee, Han-Jong Ahn, Hideo Tokunaga, Wettao Song tion. Warren Davis, Alan Hewer, Krzysztof M. Rajkowski, Walter Meinl
Soundararajalu Chandrasekhar, E. Antonio Chiocea, and Kenneth K. Tanabe Lisa M. Devereaux, Donald Jin, T. Kuber Sampath, and Ronald A. Morton. Hansruedi Glatt, and David H. Phillips.
Vili
CONTENTS OF VOLUME 60
Clinical Investigations Porphyrin Analogues as Novel Antagonists of Fibroblast Growth Factor and Castration-induced Up-Regulation of Insulin-like Growth Factor Binding
Vascular Endothelial Growth Factor Receptor Binding That Inhibit Endo- Protein-5 Potentiates Insulin-like Growth Factor-I Activity and Accelerates
2892 Color Doppler Vascularity Index Can Predict Distant Metastasis and Survival thelial Cell Proliferation, Tumor Progression, and Metastasis. David Progression to Androgen Independence in Prostate Cancer Models.
in Colon Cancer Patients. Chiung-Nien Chen, Yung-Ming Cheng, Jin-Tung Aviezer, Sara Cotton, Magda David, Amit Segev, Nona Khaselev, Nitsa Hideaki Miyake, Michael Pollak, and Martin E. Gleave.
Liang, Po-Huang Lee, Fon-Jou Hsieh, Ray-Hwang Yuan, Shih-Ming Wang, Mei Galili, Zeev Gross, and Avner Yayon.
Fang Chang, and King-Jen Chang
Structure, Function, and Targeting of Interleukin 4 Receptors on Human
2898 Vascular Endothelial Growth Factor (VEGF) in Breast Cancer: Compari- Head and Neck Cancer Cells. Koji Kawakami, Pamela Leland, and Raj K Arsenic Trioxide-mediated Growth Inhibition in MC/CAR Myeloma Cells
son of Plasma, Serum, and Tissue VEGF and Microvessel Density and Puri via Cell Cycle Arrest in Association with Induction of Cyclin-dependent
Effects of Tamoxifen. Jacqueline Adams, Pauline J. Carder, Sarah Downey Kinase Inhibitor, p21, and Apoptosis. Woo H. Park, Jae G. Seol, Eun S.
Mary A. Forbes, Kenneth MacLennan, Victoria Allgar, Sarah Kaufman, Susan Complete Regression of Xenografted Human Carcinomas by Camptoth- Kim, Jung M. Hyun, Chul W. Jung, Chung C. Lee, Byoung K. Kim, and
Hallam, Roy Bicknell, James J. Walker, Fiona Cairnduff, Peter J. Selby ecin Analogue-Carboxymethyl Dextran Conjugate (T-0128). Satoshi YoungY . Lee
Timothy J. Perren, Mark Lansdown, and Rosamonde E. Banks. Okuno, Mitsunori Harada, Toshiro Yano, Shigeru Yano, Satoko Kiuchi, Naoki
Tsuda, Yumi Sakamura, Jun Imai, Takayuki Kawaguchi, and Kenji Tsujihara.
pcA5enn3nt aermM aurtiaSatt uidoynK Esa npnoiainon ,dd LeuEFmnrxgeipd orosikluC aronec Ngeyrybt.oe r gE,Kan ivrnsitGrdio or namHnPeu snrgtaePafelvvr seehlan-gPtTeuonri,bs aoicacnioAn neunSs,m ho kPeaM oulkioen r iaaB ,of MfueltVttaail,-i IARFrrnetahcuniercbp iitntoeiPr olsnoH neobobewfyrs tk,Mi ea, t aanTsdatA rangtGdeiarctbe oewrd ReHnCaaVy.ll t mootCsSoec xlhila cl lCy,aA rncaiAltnotogilmuaae s NoafEg xyp,Sr oemsasHtiiopnspgto aktrSaiotnmi ast oAsNtK-ia2at3rii8sn., 3072 ECMFKioxuayrpmzariurhehheaiilsrrrasaooti, eo dnI kTMeaoinnwfaoai k ktaPah,o, L l iy,Tas inYuadoKml saiozuHcruk i heriAo rcmPoiirO d to agWkYraaeaend,n sada.s g iiSohTTnaaX rt,as, uio n a HJNNuaounkn ma-agSNnamaw akala,Ply o almyasCY,ieoa lzlloy lIciLhtiKurraanown gas fnFeour,Cja aisnmec,oeR tryo.,oI s
Constantinescu, Cristina Fortes, and Simone Benhamou.
Immunology
Experimental Therapeutics Sequential Loss of Cytotoxic T Lymphocyte Responses to Simian Virus 40 Epidermal Growth Factor Receptor vIII Enhances Tumorigenicity in Hu-
EAndrhiaanmcyecmienn.t Xoifu -FXaisa-nm edWiua.t ed YouAipcohpit osiMsi zuitna nRi,e nalY osCehlily ukCia rciKankoemhai, CeOllssa mbuy sLaarrcgoem aTs . AntTiogdedn DE. piStcoheplels, iBna rTb arAan tiBg. enK noTwrlaenss,g enaincd MSaitcvier DSe. veTelvoeptihinag. Osteo- mAlabne rtBr Je.aW sto ngC,a ncaenrd . MaCraer eeEn. LKi.p pmTaann.g , Xiao-Qi Gong, David K. Moscatello,
Yoshida, and Osamu Og CD59 Expressed on a Tumor Cell Surface Modulates Decay-accelerating
2919 IPPanolhlaiykbuuirnttsihiao,nt uroafR utTderodal fn slaFFtlaiitcotknyi geIrn,iA tciiaHtdui sosne iMEnei dcioAaskttaaepsse, n ttahAeern uoAnin ct iK.c anCAchceairnd g.o ElfkSfaaercn,tg eeotfA hltaih aek bna-rS3. FNStaeecuptrhooerbn l EaxsTptoromelmsiasn.is oonnS haanodh uaE nhCahennc,e s ThTeuremsoar CGarraogwinteh, iNn aai -RKaotn g MoVd.e lC hoefu nHgu, maannd 3088 VsMuaiscs hcauCelDla 3r1 I.E nSKdtoouatknh edlairadl kis, GMricorwAoltvehex sasnFedlar ac tDoeGrin/asKtirDt yR Ainc tiNlvakoai,n t-eSd mPahMillilic pr oCvEe.el sls TehlLo rupnDege,n siCRtaoyln fc everrA.-
Shahsafaei, Silvia Harneit, Ergin Kilic, and Jose A. Halperin Brekken, Efthimios Sivridis, Stelios Kakolyris, Vassilis Georgoulias, Kevin C.
Molecular Biology and Genetics Gatter, and Adrian L. Harris
Blockade of the Epidermal Growth Factor Receptor Signaling by a Novel
Tyrosine Kinase Inhibitor Leads to Apoptosis of Endothelial Cells and Therapy p53 Transdominance But No Gain of Function in Mouse Brain Tumor
of Human Pancreatic Carcinoma. Christiane J. Bruns, Carmen C. Solorzano, Model. Monika E. Hegi, Michael A. Klein, Daniela Riiedi, Patrick Chéne,
Matthew T. Harbison, Shutaro Ozawa, Rachel Tsan, Dominic Fan, James Marie-France Hamou, and Adriano Aguzzi. In Vivo Induction of Insulin-like Growth Factor-I Receptor and CD44v6
Abbruzzese, Peter Traxler, Elisabeth Buchdunger, Robert Radinsky, and Isaiah J Confers Homing and Adhesion to Murine Multiple Myeloma Cells. Kewal
Fidler DNA Copy Number Changes in Malignant Ovarian Germ Cell Tumors. Asosingh, Ursula Giinthert, Marleen H. C. Bakkus, Hendrik De Raeve, Eva
Sigrid Marie Kraggerud, Jadwiga Szymanska, Vera M. Abeler, Janne Kern, Goes, Ivan Van Riet, Ben Van Camp, and Karin Vanderkerken.
Therapeutic Efficacy of the Suicide Gene Driven by the Promoter of Vas- Mette Eknas, Sverre Heim, Manuel R. Teixeira, Claes G. Tropé, Piaivi
cular Endothelial Growth Factor Gene against Hypoxic Tumor Cells. Peltomaki, and Ragnhild A. Lothe.
SNaokbiuykaom a Koshikawa, Keizo Takenaga, Masatoshi Tagawa, and Shigeru gMeintiocg enHiac- RaCso-nivnedrusicoend oAfc tTirvaantisofno rmoif ntgh e GrMiotwotghe n-Faaccttiovra-tBe1d EfPfreoctte inb y KOinncaos-e 3105 Vtiadseo acRteicveep toIrn teSsutibntaylp esP epitni deH/uPmitauni tarTyu moArdse nyalnadt e ThCeyicrl asTei-sascuteisv atoifn gO ri;P
oBfe nTzyhleirdmeonteo leLraacntcaem Canodm poHueantd , ShKoNcKk 43P7r,o teia n NovIenld ucItnihoinb itoinr Houf mAacnqu isCiotlioonn SDiog-nSaulni ngB yuPna,t hwJaaey- Hoion n HuPmarakn, anPdr osStuantge- GiCla ncCehri. Bum-Joon Park, Jae-Il Park JReoabnb erCelcahutd,e aRnedu biJ,e anU rAs.u laL aiLsisdueer ach, Beatrice Waser, Jan-O. Gebbers, Patrick
Carcinoma Cells. Shin-ichi Yokota, Mikio Kitahara, and Kazuhiro Nagata.
Allelic Loss in the Progression of Myelodysplastic Syndrome. Naoki Mori,
2949 BEairslpyh osEpvheonnta teisn Itnhhei bitF orBmraetasito n ando f PrBoosntea te MeCtaarsctiasneosm.a SCaenldlr inIen vasBiooins,s iearn aRnodb erHt.a PhMiolrloispe tKtoie,f flEelri sabeth Hoflehner, Michael Liibbert, Hideaki Mizoguchi, 3113 AFuntunreo uAnncnuealm eMnetetsi ngs of the American
Mercedes Ferreras, Olivier Peyruchaud, Sandrine Magnetto, Frank H. Ebetino. Association for Cancer Research
Marc Colombel, Pierre Delmas, Jean-Marie Delaissé, and Philippe Clézardin. Tumor Biology Workshop on Pathobiology of Cancer
CnRMi.hut adyng gAi,lni bnse kldyKMa,uu.n rjilSanetteah : BIaDM.cn. t terFraoAiprmaecilern ,i, t DoENnrLeiAacar lry SC . oTmRuL.pa mlmobeKrraxii esgeshrMt ,o ,d EelRliWocsiin.tla llidAMa dimac Kph.at Mei. lvS cehS eiLudaCleneeruls,t, li u,l aManirSdc ahmaISaemtlnme tvuhe-Yan OnYMToviaaseymmiarasakke meixo,,pt roofe,I sTs saakoiH aoMusniShm atika sionutfga M ,uaC tDsNCCuSoo2meblkou5oittrBmoeeo ,rctu to aP,lhT oKoismkpMokhCahaasaiwtarkayac,ousi keni oN Amaaiarshi .Oaa hrak uai,e NI ,co hvMiNearaltoSso huhiuMinrragaTor,oa k keermTNHoa iomstuioaortsf,aah ,,iP ooHSYYrhiaa irssoouuPzfhhrauiiokmrrgiioo- WWAooArrCCRRkkleeRissssn hheeiaaoocrrSappplcc ehhc ooiOnnan lc MMooelCltooehgncoyfud elsrae rn cine BsiC olilinonig cyCa la nicnC earn cer
GDlisyccoovperroyt eiann-dm edCihaatreadc teMriuzlattiidornu g ofR esOiCs1t4an4c-e0.9 3,M ichaa elN ovJe.l NeIwnmhiabni,t or Jenonfi fePr- Tanudm oMro ritNoe crMoosnidse n. Factor-related Apoptosis-inducing Ligand Retains Its CRaelceenndta r Deaoft h Events
C. Rodarte, Khalid D. Benbatoul, Suzanne J. Romano, Chengzhi Zhang, Sonja Apoptosis-inducing Capacity on Bel-2- or Bel-xj-overexpressing
Krane, Edmund J. Moran, Roy T. Uyeda, Ross Dixon, Emma S. Guns, and Chemotherapy-resistant Tumor Cells. Henning Walczak, Axel Bouchon
Lawrence D. Mayer Heiko Stahl, and Peter H. Krammer. 3115 Author Index
June 15, Number 12
Advances in Brief Instability of X Chromosome Methylation in Aberrant Crypt Foci of the Mitochondrial Amplification of Death Signals Determines Thymidine Ki-
Human Colon. Nobuyuki Sakurazawa, Noritake Tanaka, Masahiko Onda, and nase/Ganciclovir-triggered Activation of Apoptosis. Christian Beltinger,
GParnocurpe atiI(cY ) DuPrcott eiCnesl.l CNaobructisnuogmua s AbeE,x prTeasksa shiH igWha taLneavbeel,s oTfa dHaihgihk o MoMbaislaiktiy Hiroyasu Esumi SDeibmaotnine. Fulda, Thomas Kammertoens, Wolfgang Uckert, and Klaus-Michael
Toshiyuki Mori, Masanori Sugiyama, Hidemasa Uchimura, Yasunori Fujioka,
Gennaro Chiappetta, Alfredo Fusco, and Yutaka Atomi
Clinical Investigations 3218 Cancer Gene Therapy by Thyroid Hormone-mediated Expression of Toxin
IEnlh1iAb-imteidoni atoefd AnBgyisotgaenndeesri s Efafnedc t Inadnudc tiToun moorf ASpuoppptroessissi on.A re RuIpnivnogl vedSh ao.i n RDeetveecrtsieo n Troafn sGcerrimp-tCieolnl- PoTlyummeorra seC elClhs aiinn tRheea ctPieorni phfeorra la -FBeltooopdr otbye inN-eMsetse-d GFaernseetst.i , VNeorréan icBa. CaMlacrattienr,r a, Maarnida MaLrutias a IzCqouriteérsd,o . Pablo de Felipe, Antonella
Weiya Xia, and Mien-Chie Hung senger RNA and 6 Human Chorionic Gonadotropin-Messenger RNA.
TTDoyhrreso esyi,P nyer RiidKcohi[an2ra,ds3 e- Jdo]vapen,y dr iAmIilndadinunc Jee .sK rDaeAkrpeiorvp,a ttoisavnieds JiPoefD 1WK8u50 6927 0 LeIunkhiebmiitcs pCe2l1l0s.8 ¢rJa-yA b!F HAanrdsrteraisck , L.M iAc.h aeHla utRkoagpgpeen,d orfM,e ngjain d LHue,r beHretn drRiuke bbMeune ller, Axel Bex, Andreas AAClgnaotyni ibsoBt.di yc S iegSPaGrlNlo,p- e1r4at.nid e sJ Aolsaaennp dh F. iAnW. ahVFlir vaon cisAcnot, ituKmaroern AL.c tivDiotnya ldosfo n,t he DaAnnat i-ChCaDc4e0,
VAamicnc,i ne-iR.n ducAeddr ianA popRtoobsiinss,: A ChNaorvleesl ClAi. nicaMla xwTerilall- ArEmnsdt roPnogi,n t? JSochhn wanHn Endocrinology In Vivo Antitumor Activity and Host Toxicity of Methoxymorpholiny! Doxo-
Scholefield, and Lindy G. Durrant Expression of Estrogen Receptor (ER)-a and ER-B in Normal and Malig- rubicin: Role of Cytochrome P450 3A. Luigi Quintieri, Antonio Rosato,
nant Prostatic Epithelial Cells: Regulation by Methylation and Involvement Eleonora Napoli, Francesco Sola, Cristina Geroni, Maura Floreani, and Paola
A Novel Histone Deacetylase Inhibitor Identified by High-Throughput in Growth Regulation. Kin-Mang Lau, Mark LaSpina, John Long, and Shuk. Zanovello.
Transcriptional Screening of a Compound Library. Gloria H. Su, Taylor Mei Ho.
A. Sohn, Byungwoo Ryu, and Scott E. Kern.
Immunology
GMDSheeaitnmnejoocimr tiueNcd i shOSiiunto crkhauH,ice dtaaud,rK ea zauKnonufdo n rtiihhN eie rcNHoki us hmiSFazuqnakuk uias,Jmh NoiGamun/asd , GKCeeeHnnlijelir oCkaSoanh dri cmiiTHznauunom.amo faru-sssa.,p ecMieTfhsimucet toMm uutG autnEidtuoanzni,s, iISSntdaageln nmctfaeionlfr ictahMte.i oPno Htyoedfne tr F,u AnncgZtaiifooangrae ln iNcaE wsatFzra,oc tgoernC onVRsaetssacpnuoclneas re CEhEnildaeopmtpehenetlttais,a l ina Gntrdho ew tGGheeo nregF aec CtoodrM-. SgDMeaaicrnfrtdfeie.tnr ee nNMiciceGohsrlm aa,sni nu alDnMoedacn cdyhGr,tli eet-niMncSi alckDCreer olalnpsGoh ifalfSlg teesis meunl,C aotleoSd.n y-iBnsr tiaiVnim vuol Waitblyis nognT ,u mFoCarhcsrti osrtE inngeoi rn eSeFhIretee3hd-a Lni,t-o
Functional Evaluation of PTEN Missense Mutations Using in Vitro Phos-
pKMahatotois,nu onsoiT,ta ikdaRoey unPSohuszouuskkpieh, atKaHasinerao myauArksuis, a y.Sah nidbS ahtCuah,ai nkgaS-seYhiiii cnh iI sHhaiInos,hki ai , HidKeena-kiic hiK atoS,h iibSah,u nsSueikkei Epidemiology GcPeearnt ehtVwiaaccyacl ilnyIe ns.dM eopdYeinofdniegenhdt o nDgoe fn dCWraiDtn4i,0c L JCoeanlanltsdh aPnIr nitmeBerrla meAsuouknit,no re1a2Ac:nt diIrvmeepw l iTc PaCitleiolnol,ns s Qtihfnrogro ugCZkah nu-,a
Chemopreventive Effects of Dietary Folate on Intestinal Polyps in Ape+/— and Jack Gauldie.
Cysteine 230 Modulates Tumor Necrosis Factor-related Apopto: ducing Msh2-—/— Mice. Jacquelin Song, Kyoung-Jin Sohn, Alan Medline, Colleen
Ligand Activity. Dai-Wu Seoi and Timothy R. Billiar Ash, Steven Gallinger, and Young-In Kim
Alcohol Consumption and Cigarette Smoking Increase the Frequency of p53 CYo nMsotnroucctlioonna,l PArnotdiubctoidoyn , 3Sa1n9d3 Cfhoarr aTcatregreitzeadt ioInm moufn oHtuhmearnaipzye d ofA nStoili-dL ewTius-
Mutations in Non-Small Ceil Lung Cancer. Steven A. Ahrendt, John T mors. Andrew M. Scott, Detlef Geleick, Michael Rubira, Kerrie Clarke,
CSihdorwa,n skyS tephen C. Yang, Li Wu, Mei-Jie Zhang, Jin Jen, and David Experimental Therapeutics FErdaonuka rd J. C.C arNri,c e, WiFliloinaam E.J . SmHayrtrhi,s , ElKiastahbertyhn StL.o ckeArrtm, ouErl,i zabJeeftfh RC.o odR,i chaArndnsa,
Regrowth of 5-Fluorouracil-treated Human Colon Cancer Cells Is Pre- Kypridis, Veronika Kronina, Roger Murphy, F-T. Lee, Zhangi Liu, Kunio
vented by the Combination of Interferon y, Indomethacin, and Phenylbu- Kitamura, Gerd Ritter, Katrina Laughton, Eric Hoffman, Antony W. Burgess
Regular Articles tyrate. Yicong Huang, Curt M. Horvath, and Samuel Waxman and Lloyd J. Old.
Carcinogenesis Addition of Matrix Mi Pp Inhibition to C Cytotoxic Molecular Biology and Genetics
Consistent and Fast Inhibition of Colon Carcinogenesis by Polyethylene Therapy Reduces Tumor Implantation and Prolongs Survival in a Murine Epigenetic Regulation of the MGMT and hMSH6 DNA Repair Genes in Cells
Glycol in Mice and Rats Given Various Carcinogens. Denis E. Corpet, Model of Human Pancreatic Cancer. Mahmudu! Haq, Alexis Shafii, Resistant to Methylating Agents. Alessandra Bearzatto, Marta Szadkowski,
Géraldine Parnaud, Maxence Delverdier, Ginette Peiffer, and Sylviane Taché Emmanuel E. Zervos, and Alexander S. Rosemurgy Peter Macpherson, Josef Jiricny, and Peter Karran
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