Cancer prevention : [main proceedings of the Fourth International Conference on "Cancer Prevention 2006," ... held during February 16-18, 2006, in St. Gallen, Switzerland ; ] with ... 27 tables PDF
Preview Cancer prevention : [main proceedings of the Fourth International Conference on "Cancer Prevention 2006," ... held during February 16-18, 2006, in St. Gallen, Switzerland ; ] with ... 27 tables
Recent Results in Cancer Research Managing Editors P. M. Schlag, Berlin · H.-J. Senn, St. Gallen Associate Editors P. Kleihues, Zürich · F. Stiefel, Lausanne B. Groner, Frankfurt · A. Wallgren, Göteborg Founding Editor P. Rentchnik, Geneva H.-J. Senn · U. Kapp (Eds.) Cancer Prevention With 48 Figures and 27 Tables 123 Prof. Dr. med. Hans-Jörg Senn Prof. Dr. med. Ursula Kapp Tumor-Zentrum ZeTuP St. Gallen/Chur (Tumordiagnostik, Behandlung + Prävention) Rorschacherstr. 150 CH-9006 St. Gallen Schweiz Library of Congress Control Number: 2006931793 ISSN 0080-0015 ISBN 10 3-540-37695-X Springer Berlin Heidelberg New York ISBN 13 978-3-540-37695-8 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broad- casting, reproduction on microfilm or in any other way, and storage in databanks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com ©Springer-Verlag Berlin Heidelberg 2007 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant pro- tective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Dr. Ute Heilmann, Heidelberg Desk editor: Dörthe Mennecke-Bühler, Heidelberg Production editor: Nadja Kroke, Leipzig Cover design: Frido Steinen Broo, eStudio Calamar, Spain Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper SPIN 11683414 21/3100/YL – 5 4 3 2 1 0 Contents Part I GeneticRiskProfilesandBiomarkersinCancerPrevention 1 AFavorableView:ProgressinCancerPreventionandScreening .......... 3 Peter Greenwald 2 GeneticRiskProfilesforCancerSusceptibilityandTherapyResponse .... 19 Helmut Bartsch, Heike Dally, Odilia Popanda, Angela Risch, Peter Schmezer 3 TumorPromotionasaTargetofCancerPrevention ........................ 37 Friedrich Marks, Gerhard Fürstenberger, Karin Müller-Decker 4 Insulin-LikeGrowthFactor-RelatedSignalingandCancerDevelopment 49 Michael Pollak Part II Inflammation,Infection,andCancerPrevention 5 CytokinesAreaTherapeuticTargetforthePrevention ofInflammation-InducedCancers .......................................... 57 Stefan Rose-John, Heidi Schooltink 6 PreventionofHepatocellularCarcinomainChronicViral HepatitisPatientswithCirrhosisbyCarotenoidMixture .................. 67 Hoyoku Nishino 7 Cox-2andCancerChemoprevention:PickingupthePieces ............... 73 Monica M. Bertagnolli VI Contents Part III PreventionofFemaleandMaleGenitalCancers 8 HumanPapillomavirusVaccine:ANewChancetoPrevent CervicalCancer .............................................................. 81 Bradley J. Monk, Ali Mahdavi 9 PreventionandEarlyDetectionofOvarianCancer:MissionImpossible? 91 Robert C. Bast Jr., Molly Brewer, Changping Zou, Mary A. Hernandez, Mary Daley, Robert Ozols, Karen Lu, Zhen Lu, Donna Badgwell, Gordon B. Mills, Steven Skates, Zhen Zhang, Dan Chan, Anna Lokshin, Yinhua Yu 10 PreventionofProstateCancer:MoreQuestionsthanData ............... 101 Hans-Peter Schmid, Daniel S. Engeler, Karl Pummer, Bernd J. Schmitz-Dräger Part IV PreventionofBreastCancer 11 PrimaryPreventionofBreastCancerbyHormone-Induced Differentiation .............................................................. 111 Irma H. Russo, Jose Russo 12 TheGenomicSignatureofBreastCancerPrevention ..................... 131 Jose Russo, Gabriela Balogh, Daniel Mailo, Patricia A. Russo, Rebecca Heulings, Irma H. Russo 13 EstrogenDeprivationforBreastCancerPrevention ...................... 151 Anthony Howell, Robert B. Clarke, Gareth Evans, Nigel Bundred, Jack Cuzick, Richard Santen, Craig Allred Part V PreventionofColorectalCancers 14 PrimaryDietaryPrevention:IstheFiberStoryOver? ..................... 171 Cheryl L. Rock 15 PreventionandEarlyDetectionofColorectalCancer–NewHorizons ... 179 Gad Rennert Contents VII Part VI PreventionofSkinandBrainTumors 16 NewPerspectivesonMelanomaPathogenesisandChemoprevention ... 191 Frank L. Meyskens, Jr., Patrick J. Farmer, Sun Yang, Hoda Anton-Culver 17 VitaminD–AnEmerging IssueinSkinCancerControl.ImplicationsforPublic HealthPracticeBasedontheAustralianExperience ...................... 197 Craig Sinclair 18 AreGliomasPreventable? .................................................. 205 Victor A. Levin Part VII TheFutureofCancer(Chemo)Prevention 19 AngiogenesisandCancerPrevention:AVision ........................... 219 Douglas M. Noonan, Roberto Benelli, Adriana Albini 20 AnEstimateofCancerMortalityRateReductionsinEurope andtheUSwith1,000IUofOralVitaminDPerDay ....................... 225 William B. Grant, Cedric F. Garland, Edward D. Gorham 21 UncoveringNovelTargetsforCancerChemoprevention ................. 235 Konstantin H. Dragnev, Qing Feng, Yan Ma, Sumit J. Shah, Candice Black, Vincent Memoli, William Nugent, James R. Rigas, Sutisak Kitareewan, Sarah Freemantle, Ethan Dmitrovsky Part VIII ConclusionsandSummary 22 ConferenceSummary ...................................................... 247 Ursula Kapp, Hans-Jörg Senn List of Contributors Adriana Albini, Director Helmuth Bartsch, Prof. Responsabile Ricerca Oncologica Deutsches Krebsforschungszentrum (DKFZ) Polo Scientifico e Tecnologico, Toxicology and Cancer Risk Factors IRCCS Multimedica Im Neuenheimer Feld 280 Viale Fantoli 16/15 69120 Heidelberg 20138 Milano Germany Italy Robert C. Bast, Jr., MD Craig Allred M.D. Anderson Cancer Center Department of Pathology Unit 355 Baylor School of Medicine 1515 Holcombe Boulevard One Baylor Plaza Houston, TX 77030-4009 Houston, TX 77030 USA USA Roberto Benelli Hoda Anton-Culver, PhD SC Oncologia Sperimentale A Professor Instituto Nazionale per la Ricerca sul Cancro Department of Epidemiology Largo Rosanna Benzi 10 Chao Family Comprehensive Cancer Center 16132 Genova University of California, Irvine Italy Irvine, CA 92601 USA Monica Bertagnolli, MD Brigham and Women’s Hospital Donna Badgwell, PhD Dana Farber Cancer Institute Department of Experimental Therapeutics c/o Daria Christiansen University of Texas Room CA 104 M.D. Anderson Cancer Center 75 Francis Street Houston, TX 77030 Boston, MA 02115 USA USA Gabriela Balogh, PhD Candice Black, DO Breast Cancer Research Laboratory Department of Pathology Fox Chase Cancer Center Dartmouth Medical School 333 Cottman Avenue Hanover, NH 03755 Philadelphia, PA 19111 USA USA X List of Contributors Molly Brewer Ethan Dmitrovsky, MD Division of Gynecologic Oncology Department of Pharmacology and Toxicology University of Arizona Dartmouth Medical School Tucson, AZ 85724 7650 Remsen USA Hanover, NH 03755 USA Nigel Bundred University Department of Surgery Konstantin H. Dragnev, MD University Hospital of South Manchester Department of Medicine Whythenshaw Hospital Dartmouth Medical School Manchester M23 9LT Hanover, NH 03755 UK USA Dan Chan, PhD Daniel S. Engeler, Dr. med Johns Hopkins Medical Center Department of Urology Baltimore, MD 21205 Kantonsspital USA 9007 St. Gallen Switzerland Robert B. Clarke Cancer Research UK Gareth Evans Department of Medical Oncology Department of Medical Genetics Christie Hospital St. Mary’s Hospital University of Manchester Hathersage Road Wilmslow Road Manchester M13 0JH Manchester M20 4BX UK UK Patrick J. Farmer, PhD Jack Cuzick, Prof. Department of Chemistry Cancer Research UK Chao Family Comprehensive Cancer Center Department of Epidemiology, University of California, Irvine Mathematics and Statistics Irvine, CA 92601 Wolfson Institute of Preventive Medicine USA Charterhouse Square London EC1M 6BQ Qing Feng, PhD UK Department of Pharmacology and Toxicology Dartmouth Medical School Mary Daley, MD Hanover, NH 03755 Fox Chase Cancer Center USA 333 Cottman Avenue Philadelphia, PA 19111 Sarah Freemantle, PhD USA Research Assistant Professor Department of Pharmacology and Toxicology Heike Dally Dartmouth Medical School Deutsches Krebsforschungszentrum (DKFZ) Hanover, NH 03755 Toxicology and Cancer Risk Factors USA Im Neuenheimer Feld 280 69120 Heidelberg Gerhard Fürstenberger, PhD Germany Deutsches Krebsforschungszentrum (DKFZ) Research Program Cell and Tumor Biology Im Neuenheimer Feld 280 69120 Heidelberg Germany XI Cedric F. Garland, PhD Anthony Howell, Prof. Department of Family and Preventive Medicine CRUK Department of Medical Oncology 0631C Christie Hospital University of California, San Diego University of Manchester 9500 Gilman Drive Wilmslow Road La Jolla, CA 92093-0631 Manchester M20 4BX USA UK Edward D. Gorham, PhD Ursula Kapp, Prof. Dr. med Department of Family and Preventive Medicine Tumor-Zentrum ZeTuP St. Gallen/Chur 0631C Rorschacherstrasse 15 University of California, San Diego 9006 St. Gallen 9500 Gilman Drive Switzerland La Jolla, CA 92093-0631 USA Sutisak Kitareewan, PhD Instructor William B. Grant, PhD Department of Pharmacology and Toxicology Sunlight, Nutrition and Health Research Center Dartmouth Medical School (SUNARC) Hanover, NH 03755 2115 Van Ness Avenue, MB 101 USA San Francisco, CA 94109-2510 USA Victor A. Levin, MD Neuro-Oncology Unit 431 Peter Greenwald, MD, PhD University of Texas Division of Cancer Prevention M.D. Anderson Cancer Center National Cancer Institute P.O. Box 301402 National Institutes of Health Houston, TX 77230-1402 6130 Executive Boulevard USA Suite 2040 Bethesda, MD 20892-7309 Anna Lokshin, PhD USA University of Pittsburgh, Cancer Institute Mary A. Hernandez, RN Pittsburgh, PA 15232 Department of Experimental Therapeutics USA University of Texas M.D. Anderson Cancer Center Karen Lu Houston, TX 77030 Department of Gynecologic Oncology USA University of Texas M.D. Anderson Cancer Center Rebecca Heulings, BS Houston, TX 77030 Breast Cancer Research Laboratory USA Fox Chase Cancer Center 333 Cottman Avenue Zhen Lu, MD Philadelphia, PA 19111 Department of Experimental Therapeutics USA University of Texas M.D. Anderson Cancer Center Houston, TX 77030 USA
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