Cancer Pain PDF
Preview Cancer Pain
Magdi Hanna Zbigniew (Ben) Zylicz Editors Cancer Pain 123 Cancer Pain Magdi Hanna (cid:129) Z bigniew (Ben) Zylicz Editors Cancer Pain Editors Magdi Hanna , MBBCH, FCA Zbigniew (Ben) Zylicz , MD, PhD Analgesics and Pain Research Unit Department of Research and Education (APR LTD) Hildegard Hospiz Beckenham Basel Kent Switzerland United Kingdom ISBN 978-0-85729-229-2 ISBN 978-0-85729-230-8 (eBook) DOI 10.1007/978-0-85729-230-8 Springer London Heidelberg New York Dordrecht Library of Congress Control Number: 2013945729 © Springer-Verlag London 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, speci fi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on micro fi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied speci fi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a speci fi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) To Kate , Sam , Jonathan , and Daniel for their everlasting support . Magdi Hanna In memory of my Mother who died many years ago of cancer, she was my best teacher ever. Zbigniew (Ben) Zylicz Preface During the professional life of the editors, and most of the authors, cancer pain management has undergone radical improvements. We have seen regular opioids adopted as the norm, and oral administration has become the pre- ferred route of administration despite early resistance from medics and the public. However, in spite of these improvements, recent studies demonstrate that one-third of adult patients with cancer who are in active therapy and two- thirds of patients in the advanced stages of the disease still suffer from signi fi cant pain. To face this challenge, we have been forced to develop a fresh understand- ing of the dynamic pathophysiology of cancer pain, and it has become clear that a modern and more comprehensive model for cancer pain management is necessary. Mechanism-based and multimodal combination therapies (including inter- vention techniques) that are tailored to the needs of the individual should prove the most ef fi cacious techniques in the fi ght against cancer pain. The aim is, as ever, to optimise pain relief, minimise adverse effects of the treat- ment, and improve long-term outcome. Improved survival rates among cancer sufferers, a result of enhanced anti- cancer therapy, have had the paradoxical effect of creating a signi fi cantly more complex pain syndrome. This has added a new clinical challenge for patients and physicians, and the chapters of this book are aimed squarely at confronting these issues. We have placed speci fi c emphasis on the modern challenges that cancer care teams face in the twenty- fi rst century and aim to provide an up-to-date outline of the current thinking in the treatment of can- cer pain. We are deeply indebted to all those who contributed to this book despite the pressure of their work and would like to acknowledge our gratitude to our publishers for their constant help and assistance. Beckenham, Kent, UK Magdi Hanna, MBBCH, FCA vii Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Magdi Hanna and Zbigniew (Ben) Zylicz 2 Epidemiology of Pain in Cancer. . . . . . . . . . . . . . . . . . . . . . . . . 5 Irene J. Higginson, Fliss E.M. Murtagh, and Thomas R. Osborne 3 Recent Advances in Cancer Treatment . . . . . . . . . . . . . . . . . . . 25 M.J. Lind 4 Pharmacogenetics of Pain in Cancer . . . . . . . . . . . . . . . . . . . . . 37 Pål Klepstad 5 Mechanisms in Cancer Pain . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Jerzy Wordliczek and Renata Zajaczkowska 6 Preclinical Cancer Pain Models . . . . . . . . . . . . . . . . . . . . . . . . . 71 Joanna Mika, Wioletta Makuch, and Barbara Przewlocka 7 Pain Assessment, Recognising Clinical Patterns, and Cancer Pain Syndromes. . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Malgorzata Krajnik and Zbigniew (Ben) Zylicz 8 Opioids, Their Receptors, and Pharmacology . . . . . . . . . . . . . 109 R.A.F.J. D’Costa and Magdi Hanna 9 Critical Appraisal of the Breakthrough Pain in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 Zbigniew (Ben) Zylicz 10 Opioid-Induced Hyperalgesia. . . . . . . . . . . . . . . . . . . . . . . . . . . 131 Jakob Sørensen and Per Sjøgren 11 The Non-Pharmacological and Local Pharmacological Methods of Pain Control. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 Remigiusz Lecybyl 12 New Drugs in Management of Pain in Cancer . . . . . . . . . . . . . 153 Marie Fallon 13 Neuropathic Component of Pain in Cancer . . . . . . . . . . . . . . . 165 Jung Hun Kang and Eduardo Bruera 14 Noncancer-Related Pain in Daily Practice. . . . . . . . . . . . . . . . . 191 Zbigniew (Ben) Zylicz ix
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