Cancer medicine

2572 Pages·2000·64.633 MB·English

by  James F. Holland, Donald W., M.D. Kufe, Raphael E., M.D. Pollock, Ralph R., M.D. Weichselbaum, Emil, III, M.D. Frei, Robert C., Jr. Bast

Cancer
Medicine
e.5
Editors
ROBERTC.BASTJR.,M.D.
Internist and Professor of Medicine
Vice President for Translational Research
Harry Carothers Wiess Chair for Cancer Research
University of Texas
MD Anderson Cancer Center
Houston, Texas
DONALDW.KUFE,M.D.
Professor of Medicine
Dana-Farber Cancer Institute
Harvard Medical School
Boston, Massachusetts
RAPHAELE.POLLOCK,M.D.,PH.D.
Head, Division of Surgery
Professor and Chairman, Department of Surgical Oncology
Senator A.M. Aiken, Jr. Distinguished Chair
University of Texas
MD Anderson Cancer Center
Houston, Texas
RALPHR.WEICHSELBAUM,M.D.
Harold H. Hines Professor
Chairman, Department of Radiation and Cellular Oncology
University of Chicago Hospital
Director, Chicago Tumor Institute
University of Chicago
Chicago, Illinois
JAMESF.HOLLAND,M.D.,SC.D.(h.c.)
Distinguished Professor of Neoplastic Diseases
Director Emeritus, Derald H. Ruttenberg Cancer Center
Mount Sinai School of Medicine
New York, New York
EMILFREI,III,M.D.
Physician-in-Chief, Emeritus
Dana-Farber Cancer Institute
Richard and Susan Smith Distinguished Professor of Medicine
Harvard Medical School
Boston, Massachusetts
Associate Editor
TEDS.GANSLER,MD,MBA
Director of Health Content
American Cancer Society
Atlanta, Georgia
Cancer
Medicine
e.5
An approved publication of the
2000
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Table of Contents XXV
C
ONTENTS
Section 1 CANCER BIOLOGY 14. Ionizing Radiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207
John B. Little
1. Molecular Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
15. Ultraviolet Radiation Carcinogenesis . . . . . . . . . . . . . . . . 219
Barrett J. Rollins, Todd R. Golub, Kornelia Polyak,
James E. Cleaver, David L. Mitchell
Charles D. Stiles
16. Physical Carcinogens . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
2. Cell Proliferation, Differentiation, and Apoptosis . . . . . . . 17
Cesare Maltoni, Franco Minardi, James F. Holland
Michael Andreeff, David W. Goodrich, Arthur B. Pardee
17. Trauma and Inflammation . . . . . . . . . . . . . . . . . . . . . . . . 235
3. Growth Factor Signal Transduction in Cancer . . . . . . . . . . 33
John F. Gaeta
Paolo Fedi, Alec Kimmelman, Stuart A. Aaronson
18. Tumor Viruses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237
4. Oncogenes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56
Marco A. Pierotti, Steven A. Schichman, Howard A. Fine, Joseph G. Sodroski
Gabriella Sozzi, Carlo M. Croce 19. Herpesviruses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 252
5. Tumor Suppressor Gene Defects in Jeffrey I. Cohen
Human Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 20. Papillomaviruses and Cervical Neoplasia . . . . . . . . . . . . 259
Eric R. Fearon, Bert Vogelstein Catherine M. McLachlin, Christopher P. Crum
6. Recurring Chromosome Rearrangements in Human 21. Hepatitis Viruses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 266
Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
Max W. Sung, Swan N. Thung, George Acs
Olufunmilayo I. Olopade, Olatoyosi M. Sobulo,
Janet D. Rowley 22. Parasites . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Piero Mustacchi
7. Biochemistry of Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . 108
Raymond W. Ruddon
Section 4 CANCER EPIDEMIOLOGY
8. Invasion and Metastases . . . . . . . . . . . . . . . . . . . . . . . . . . 121
Lance A. Liotta, Elise C. Kohn 23. Cancer Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283
Michael J. Thun, Phyllis A. Wingo
9. Tumor Angiogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
Judah Folkman
Section 5 THEORY AND PRACTICE OF CLINICAL TRIALS
Section 2 TUMOR IMMUNOLOGY
24. Theory and Practice of Clinical Trials . . . . . . . . . . . . . . . 298
10. Tumor Immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 Marvin Zelen
Jeffrey Schlom, Scott I. Abrams
Section 6 CANCER PREVENTION
Section 3 CANCER ETIOLOGY
25. Prevention of Tobacco-Related Cancers . . . . . . . . . . . . . . 314
11. Genetic Predisposition to Cancer . . . . . . . . . . . . . . . . . . . 168 Paul F. Engstrom, Margie Clapper, Robert Schnoll,
Marcia S. Brose, Tom Smyrk, Barbara Weber, C. Tracy Orleans
Henry T. Lynch
26. Nutrition in the Etiology and Prevention of Cancer . . . . . 328
12. Chemical Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . 185 Steven K. Clinton, Elizabeth C. Miller,
Ainsley Weston, Curtis C. Harris Edward L. Giovannucci
13. Hormones and the Etiology of Cancer . . . . . . . . . . . . . . . 195 27. Chemoprevention of Cancer . . . . . . . . . . . . . . . . . . . . . . . 351
Brian E. Henderson, Leslie Bernstein, Ronald K. Ross Michael B. Sporn, Scott M. Lippman
XXVI CANCER MEDICINE 5
Section 7 CANCER SCREENING AND EARLY DETECTION Section 13 PRINCIPLES OF CHEMOTHERAPY
28. Cancer Screening and Early Detection . . . . . . . . . . . . . . . 362 38. Cytokinetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 511
Harmon J. Eyre, Robert A. Smith, Curtis J. Mettlin Teresa Ann Gilewski, Chau Dang, Antonella Surbone,
Larry Norton
Section 8 PRINCIPLES OF CANCER PATHOLOGY
39. Drug Resistance and its Clinical Circumvention . . . . . . . 539
Charles S. Morrow, Kenneth H. Cowan
29. Principles of Cancer Pathology . . . . . . . . . . . . . . . . . . . . 384
James L. Connolly, Stuart J. Schnitt, Helen H. Wang, 40. Principles of Dose, Schedule, and Combination
Ann M. Dvorak, Harold F. Dvorak Chemotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 556
Emil Frei III, Karen H. Antman
Section 9 PRINCIPLES OF IMAGING
41. Regional Chemotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . 569
Maurie Markman
30. Principles of Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . 400
Richard J. Steckel 42. Animal Models in Developmental Therapeutics . . . . . . . 573
Samir N. Khleif, Gregory A. Curt
a. Imaging Cancer of Unknown Primary Site . . . . . . . . . . . 403
A. Robert Kagan, Richard J. Steckel 43. In Vitro and In Vivo Predictive Tests . . . . . . . . . . . . . . . . 585
Axel-R. Hanauska, Daniel D. Von Hoff
b. Imaging Neoplasms of the Head and Neck and Central
Nervous System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 405 44. Pharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 589
Robert B. Lufkin Mark J. Ratain, William Plunkett
c. Imaging Neoplasms of the Thorax . . . . . . . . . . . . . . . . . . 409 45. Toxicology by Organ System . . . . . . . . . . . . . . . . . . . . . . 602
Poonam V. Batra Michael R. Grever, Charles K. Grieshaber
d. Imaging Neoplasms of the Abdomen and Pelvis . . . . . . . 413 Section 14 CHEMOTHERAPEUTIC AGENTS
Robert A. Halvorsen Jr, William M. Thompson
e. Cross-Sectional Imaging of Musculoskeletal 46. Folate Antagonists . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 612
Neoplasms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 418 Barton A. Kamen, Peter D. Cole, Joseph R. Bertino
Leanne L. Seeger 47. Pyrimidine and Purine Antimetabolites . . . . . . . . . . . . . . 625
f. Imaging the Breast . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 420 Giuseppe Pizzorno, Robert E. Handschumacher,
Lawrence W. Bassett Yung-Chi Cheng
g. Ultrasound in Cancer Medicine . . . . . . . . . . . . . . . . . . . . 428 48. Alkylating Agents and Platinum Antitumor Compounds . . . 648
Edward G. Grant D. Michael Colvin
h. Radionuclide Imaging in Cancer Medicine . . . . . . . . . . . 433 49. Anthracyclines and DNA Intercalators /
Randall A. Hawkins Epipodophyllotoxins / DNA Topoisomerases . . . . . . . . . 670
Eric H. Rubin, William N. Hait
i. Perspectives in Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . 439
Richard J. Steckel 50. Microtubule-Targeting Anticancer Drugs Derived from
Plants and Microbes: VincaAlkaloids, Taxanes, and
31. Interventional Radiology for the Cancer Patient . . . . . . . 440
Epothilones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 680
Marshall Hicks, Chusilp Charnsangavej,
William T. Beck, Carol E. Cass, Peter J. Houghton
Michael Wallace
51. Asparaginase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 699
Section 10 PRINCIPLES OF SURGICAL ONCOLOGY JoAnne Kurtzberg
32. Principles of Surgical Oncology . . . . . . . . . . . . . . . . . . . . 448 Section 15 PRINCIPLES OF ENDOCRINE THERAPY
Raphael E. Pollock, Donald L. Morton
52. Steroid Hormone Binding and Hormone Receptors . . . . 706
33. Vascular Access in Cancer Patients . . . . . . . . . . . . . . . . . 459 Eugene R. DeSombre, Elwood V. Jensen
Michail Shafir
53. Hypothalamic and Other Peptide Hormones . . . . . . . . . . 715
Section 11 PRINCIPLES OF RADIATION ONCOLOGY Andrew V. Schally, Ana Maria Comaru-Schally
54. Corticosteroids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 730
34. Physical and Biologic Basis of Radiation Oncology . . . . 465 Lorraine I. McKay, John A. Cidlowski
Arno J. Mundt, John C. Roeske, Ralph R. Weichselbaum
55. Estrogens and Antiestrogens . . . . . . . . . . . . . . . . . . . . . . . 743
35. Principles of Hyperthermia . . . . . . . . . . . . . . . . . . . . . . . 479 V. Craig Jordan
Daniel S. Kapp, George M. Hahn, Robert W. Carlson
56. Clinical Use of Aromatase Inhibitors in
36. Photodynamic Therapy of Cancer . . . . . . . . . . . . . . . . . . 489 Breast Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 751
Tayyaba Hasan, Anne C.E. Moor, Bernard Ortel Harold A. Harvey
57. Progestins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 760
Section 12 PRINCIPLES OF MEDICAL ONCOLOGY
Kenneth S. McCarty Jr, Kenneth S. McCarty Sr
37. Principles of Medical Oncology . . . . . . . . . . . . . . . . . . . . 503 58. Androgen Deprivation Strategies in the Treatment of
James F. Holland, Emil Frei III, Donald W. Kufe, Advanced Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . 765
Robert C. Bast Jr Samuel R. Denmeade, John T. Isaacs
Table of Contents XXVII
59. Paraneoplastic Syndromes . . . . . . . . . . . . . . . . . . . . . . . . 777 Section 23 PRINCIPLES OF SOCIETAL ONCOLOGY
William D. Odell
74. Ethical Aspects of Caring for Patients with Cancer . . . . 1001
Section 16 PRINCIPLES OF BIOTHERAPEUTICS Ezekiel J. Emanuel, Steven Joffe
75. Legal Aspects of Cancer . . . . . . . . . . . . . . . . . . . . . . . . . 1017
60. Immunostimulants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 790
Joseph M. Taraska
Robert C. Bast Jr, Donald L. Morton
76. The Government and Cancer Medicine . . . . . . . . . . . . . 1025
61. Active Specific Immunotherapy with Vaccines . . . . . . . . 800
John E. Ultmann, Marguerite Donoghue Baxter,
Mepur H. Ravindranath, Donald L. Morton
Terry Lierman
62. Interferons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 815
77. Clinical Oncology in a Changing
Ernest C. Borden, Bryan R.G. Williams
Health Care Environment . . . . . . . . . . . . . . . . . . . . . . . . . 1035
63. Cytokines: Biology and Applications in Cancer . . . . . . . 825 Martin N. Raber, Joseph S. Bailes
Medicine
78. Outcomes Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . 1039
Elizabeth A. Grimm
Jane C. Weeks
64. Hematopoietic Growth Factors . . . . . . . . . . . . . . . . . . . . . 835
79. Questionable Cancer Therapies . . . . . . . . . . . . . . . . . . . 1045
Razelle Kurzrock
Barrie R. Cassileth
65. Monoclonal Serotherapy . . . . . . . . . . . . . . . . . . . . . . . . . 860
Robert C. Bast Jr., Michael R. Zalutsky, Section 24 NEOPLASMS OF THE CENTRAL
Robert J. Kreitman, Edward A. Sausville, NERVOUS SYSTEM
Arthur R. Frankel
80. Neoplasms of the Central Nervous System . . . . . . . . . . 1055
Section 17 PRINCIPLES OF GENE THERAPY Michael D. Prados
66. Cancer Gene Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . 876 Section 25 NEOPLASMS OF THE EYE
Donald W. Kufe, Sunil Advanti, Ralph Weichselbaum
81. Neoplasms of the Eye . . . . . . . . . . . . . . . . . . . . . . . . . . . 1083
Section 18 PRINCIPLES OF BONE MARROW David H. Abramson, Ira J. Dunkel,
TRANSPLANTATION Beryl McCormick
67. Autologous Bone Marrow and Section 26 NEOPLASMS OF THE ENDOCRINE GLANDS
Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . 890
William P. Peters, Caroline Hamm, 82. Pituitary Neoplasms . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1097
Roy D. Baynes Aviva Abosch, Charles B. Wilson
68. Transplantation of Allogeneic Hematopoietic Cells 83. Neoplasms of the Thyroid . . . . . . . . . . . . . . . . . . . . . . . 1105
for the Treatment of Malignancies . . . . . . . . . . . . . . . . . 911 Steven I. Sherman, Ann M. Gillenwater
Richard J. O’Reilly, Esperanza B. Papadopoulos,
84. Neoplasms of the Adrenal Cortex . . . . . . . . . . . . . . . . . 1115
Trudy N. Small
David E. Schteingart
Section 19 PRINCIPLES OF PSYCHO-ONCOLOGY 85. Neoplasms of the Neuroendocrine System and
Neoplasms of the Gastroenteropancreatic
69. Principles of Psycho-Oncology . . . . . . . . . . . . . . . . . . . . 943 Endocrine System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1121
Jimmie C. Holland, Jane Gooen-Piels Larry K. Kvols, Roger R. Perry, Aaron I. Vinik,
Li-Teh Wu, Phillippe Chaninian, Stephen B. Baylin,
Section 20 PRINCIPLES OF ONCOLOGY NURSING Norman W. Thompson
70. Principles of Oncology Nursing . . . . . . . . . . . . . . . . . . . . 959 Section 27 NEOPLASMS OF THE HEAD AND NECK
Mary Johnson, Connie Henke Yarbro
86. Head and Neck Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . 1173
Section 21 PRINCIPLES OF CANCER REHABILITATION Gary L. Clayman, Scott M. Lippman,
MEDICINE George E. Laramore, Waun Ki Hong
87. Odontogenic Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . 1221
71. Principles of Cancer Rehabilitation Medicine . . . . . . . . . 971
George Thomas Gallagher, Gerald Shklar
Kristjan T. Ragnarsson, David C. Thomas
Section 28 NEOPLASMS OF THE THORAX
Section 22 PRINCIPLES OF MULTIDISCIPLINARY
MANAGEMENT
88. Cancer of the Lung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1227
Ara A. Vaporciyan, Jonathan C. Nesbitt, Jin Soo Lee,
72. Principles of Multidisciplinary Management . . . . . . . . . . 986
Craig W. Stevens, Ritsuko Komaki, Jack A. Roth
James F. Holland, Emil Frei III, Donald W. Kufe,
Robert C. Bast Jr., Raphael E. Pollock, 89. Malignant Mesothelioma . . . . . . . . . . . . . . . . . . . . . . . . 1293
Ralph R. Weichselbaum A. Philippe Chahinian, Harvey I. Pass
73. Palliative Care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 992 90. Thymomas and Thymic Tumors . . . . . . . . . . . . . . . . . . . 1313
Alan C. Carver, Kathleen M. Foley A. Philippe Chahinian
XXVIII CANCER MEDICINE 5
91. Tumors of the Heart and Great Vessels . . . . . . . . . . . . . 1319 Section 31 NEOPLASMS OF THE FEMALE
A. Philippe Chahinian, David E. Gutstein, REPRODUCTIVE ORGANS
Valentin Fuster
111. Neoplasms of the Vulva and Vagina . . . . . . . . . . . . . . . . 1622
92. Primary Germ Cell Tumors of the Thorax . . . . . . . . . . . 1322
Jacob Rotmensch, Arthur L. Herbst
John D. Hainsworth, F. Anthony Greco
112. Neoplasms of the Cervix . . . . . . . . . . . . . . . . . . . . . . . . 1631
93. Metastatic Tumors in the Thorax . . . . . . . . . . . . . . . . . . 1329
J. Taylor Wharton, Guillermo Tortolero-Luna
Donald L. Morton, Perry Shen
113. Endometrial Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1667
Section 29 NEOPLASMS OF THE ALIMENTARY CANAL Carmel J. Cohen, Gillian M. Thomas,
George S. Hagopian
94. Neoplasms of the Esophagus . . . . . . . . . . . . . . . . . . . . . 1340 114. Neoplasms of the Fallopian Tube . . . . . . . . . . . . . . . . . . 1683
Mark K. Ferguson Carmel J. Cohen, Gillian M. Thomas,
95. Neoplasms of the Stomach . . . . . . . . . . . . . . . . . . . . . . . 1355 George S. Hagopian
Howard W. Bruckner, John C. Morris, 115. Ovarian Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1687
Paul Mansfield Jonathan S. Berek, Gillian M. Thomas,
Robert F. Ozols
96. Primary Neoplasms of the Liver . . . . . . . . . . . . . . . . . . 1391
Paul F. Engstrom, Elin Sigurdson, 116. Gestational Trophoblastic Disease . . . . . . . . . . . . . . . . . 1721
Alison A. Evans Ross S. Berkowitz, Donald P. Goldstein
97. Treatment of Liver Metastases . . . . . . . . . . . . . . . . . . . . 1402 117. Gynecologic Sarcomas . . . . . . . . . . . . . . . . . . . . . . . . . . 1727
Nancy E. Kemeny, Yuman Fong Carmel J. Cohen, Gillian M. Thomas,
George S. Hagopian
98. The Gallbladder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1415
Steven A. Curley
Section 32 NEOPLASMS OF THE BREAST
99. Diagnosis and Management of Biliary Tract Cancer . . . 1422
Steven A. Curley 118. Neoplasms of the Breast . . . . . . . . . . . . . . . . . . . . . . . . . 1735
Richard G. Margolese, Bernard Fisher,
100. Neoplasms of the Ampulla of Vater . . . . . . . . . . . . . . . . 1431
Gabriel N. Hortobagyi, William D. Bloomer
Douglas B. Evans, Robert A. Wolff
101. Neoplasms of the Exocrine Pancreas . . . . . . . . . . . . . . . 1436 Section 33 NEOPLASMS OF THE SKIN
Robert A. Wolff, James L. Abbruzzese,
Douglas B. Evans 119. Neoplasms of the Skin . . . . . . . . . . . . . . . . . . . . . . . . . . 1823
Arthur K.F. Tong, Thomas B. Fitzpatrick
102. Neoplasms of the Small Intestine, Vermiform
Appendix,and Peritoneum . . . . . . . . . . . . . . . . . . . . . . . 1465
Section 34 MALIGNANT MELANOMA
Erik Barquist, Michael Zinner
103. Adenocarcinoma of the Colon and Rectum . . . . . . . . . . 1472 120. Malignant Melanoma . . . . . . . . . . . . . . . . . . . . . . . . . . . 1849
Howard W. Bruckner, John Pittrelli, Donald L. Morton, Richard Essner,
Marnin Merrick John M. Kirkwood, Robert C. Wollman
104. Neoplasms of the Anus . . . . . . . . . . . . . . . . . . . . . . . . . . 1521
Section 35 NEOPLASMS OF THE BONE AND
Brenda Shank, Warren E. Enker,
SOFT TISSUE
Marshall S. Flam
121. Bone Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1870
Section 30 NEOPLASMS OF THE GENITOURINARY TRACT
Gerald Rosen, Charles A. Forscher,
Henry J. Mankin, Michael T. Selch
105. Renal Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . 1530
Jerome P. Richie, Philip W. Kantoff, 122. Sarcomas of Nonosseous Tissues . . . . . . . . . . . . . . . . . . 1903
Charles L. Shapiro Peter W.T. Pisters, Brian O’Sullivan,
George D. Demetri
106. Neoplasms of the Renal Pelvis and Ureter . . . . . . . . . . . 1539
Jerome P. Richie, Philip W. Kantoff Section 36 NEOPLASMS OF THE HEMATOPOIETIC
SYSTEM
107. Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1543
Philip W. Kantoff, Anthony L. Zeitman,
123. Myelodysplastic Syndrome . . . . . . . . . . . . . . . . . . . . . . 1931
Kenneth Wishnow
Lewis R. Silverman
108. Neoplasms of the Prostate . . . . . . . . . . . . . . . . . . . . . . . 1559
124. Acute Myeloid Leukemia in Adults . . . . . . . . . . . . . . . . 1947
William K. Oh, Mark Hurwitz, Anthony V. D’Amico,
Charles A. Schiffer, Richard M. Stone
Jerome P. Richie, Philip W. Kantoff
125. Chronic Myeloid Leukemia . . . . . . . . . . . . . . . . . . . . . . 1971
109. Neoplasms of the Penis . . . . . . . . . . . . . . . . . . . . . . . . . 1589
Richard T. Silver
Victor A. Marcial, A. Puras, V.A. Marcial-Vega
110. Neoplasms of the Testis . . . . . . . . . . . . . . . . . . . . . . . . . 1596 126. Acute Lymphocytic Leukemia in Adults . . . . . . . . . . . . 1979
Charles A. Schiffer, Richard A. Larson
Craig R. Nichols, Robert Timmerman,
Richard S. Foster, Bruce J. Roth, 127. Chronic Lymphocytic Leukemia . . . . . . . . . . . . . . . . . . 1989
Lawrence H. Einhorn Kanti R. Rai, Michael J. Keating
Table of Contents XXIX
128. Hairy-Cell Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . 2002 e. Soft Tissue Sarcomas of Childhood . . . . . . . . . . . . . . . . 2198
Harvey M. Golomb, James Vardiman Leonard H. Wexler, Lee J. Helman
129. Hodgkin’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2010
Section 40 COMPLICATIONS OF CANCER AND ITS
Peter M. Mauch, James O. Armitage
TREATMENT
130. Non–Hodgkin’s Lymphomas . . . . . . . . . . . . . . . . . . . . . 2034
Arnold S. Freedman, Lee M. Nadler 140. Management of Cancer Pain . . . . . . . . . . . . . . . . . . . . . 2204
Alan C. Carver, Kathleen M. Foley
131. Mycosis Fungoides and the Sézary Syndrome . . . . . . . . 2059
Youn H. Kim, Richard T. Hoppe 141. Anorexia and Cachexia . . . . . . . . . . . . . . . . . . . . . . . . . 2224
Takao Ohnuma
132. Plasma Cell Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2066
Kenneth C. Anderson 142. Antiemetic Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2243
Richard J. Gralla
133. Mast Cell Leukemia and Other Mast Cell Neoplasms . . 2086
Richard M. Stone, Steven H. Bernstein 143. Neurologic Complications . . . . . . . . . . . . . . . . . . . . . . . 2251
Lisa M. DeAngelis, Jerome B. Posner
134. Polycythemia Vera and Essential Thrombocythemia . . . 2090
Scott Murphy 144. Dermatologic Complications of
Cancer Chemotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . 2271
Section 37 NEOPLASMS IN AIDS Narin Apisarnthanarax, Madeleine Duvic
145. Skeletal Complications . . . . . . . . . . . . . . . . . . . . . . . . . . 2279
135. Neoplasms in Acquired Immunodeficiency Syndrome. . . 2099 Samuel Kenan, Gabriel N. Hortobagyi
David T. Scadden
146. Hematologic Complications and
Blood Bank Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2291
Section 38 NEOPLASMS OF UNKNOWN PRIMARY SITE
Kenneth C. Anderson
136. Neoplasms of Unknown Primary Site . . . . . . . . . . . . . . 2115 147. Coagulopathic Complications of Cancer . . . . . . . . . . . . 2309
John D. Hainsworth, F. Anthony Greco Sabine Eichinger, Kenneth A. Bauer
148. Urologic Complications . . . . . . . . . . . . . . . . . . . . . . . . . 2317
Section 39 NEOPLASMS IN CHILDREN
Christopher J. Logothetis, Jose E. Sarriera
137a. Principles and Practice of Pediatric Oncology . . . . . . . . 2125 149. Cardiac Complications . . . . . . . . . . . . . . . . . . . . . . . . . . 2324
Michael A. Weiner Michael S. Ewer, Robert S. Benjamin
b. Incidence, Origins, Epidemiology . . . . . . . . . . . . . . . . . 2128 150. Respiratory Complications . . . . . . . . . . . . . . . . . . . . . . . 2340
Leslie L. Robison Roy B. Jones
c. Principles of Pediatric Radiation Oncology . . . . . . . . . . 2131 151. Liver Function and Hepatotoxicity in Cancer . . . . . . . . 2346
John C. Breneman, Ashwatha Narayana Laurie D. DeLeve
d. Late Effects of Treatment of Cancer in Children 152. Gastrointestinal Complications . . . . . . . . . . . . . . . . . . . 2359
and Adolescents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2133 Frank A. Sinicrope, Bernard Levin
Daniel M. Green 153. Oral Complications . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2371
Stephen T. Sonis
138a. Childhood Acute Lymphoblastic Leukemia . . . . . . . . . . 2140
Paul S. Gaynon, Michael E. Trigg, 154. Gonadal Complications . . . . . . . . . . . . . . . . . . . . . . . . . 2380
Faith M. Uckun Catherine E. Klein
b. Pediatric Acute Myeloid Leukemia . . . . . . . . . . . . . . . . 2151 155. Endocrine Complications . . . . . . . . . . . . . . . . . . . . . . . . 2389
Richard Aplenc, Beverly Lange S. Jim Yeung, Robert F. Gagel
c. Hodgkin’s Disease in Children and Adolescents . . . . . . 2157 156. Secondary Cancers: Incidence,
Allen Chauvenet, Cindy L. Schwartz, Risk Factors, and Management . . . . . . . . . . . . . . . . . . . 2399
Michael A. Weiner Susan R. Rheingold, Alfred I. Neugut,
Anna T. Meadows
d. Non-Hodgkin’s Lymphoma in Children . . . . . . . . . . . . . 2162
Mitchell S. Cairo, Sherrie Perkins
Section 41 INFECTIONS IN PATIENTS WITH CANCER
e. Langerhans’Cell Histiocytosis . . . . . . . . . . . . . . . . . . . . 2168
Kara M. Kelly 157. Infections in Patients with Cancer . . . . . . . . . . . . . . . . . 2407
Kenneth V. I. Rolston, Gerald P. Brody
139a. Hepatic Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2171
Marcio Henrique Malogolowkin
Section 42 ONCOLOGIC EMERGENCIES
b. Renal Tumors of Childhood . . . . . . . . . . . . . . . . . . . . . . 2174
Paul E. Grundy, Daniel M. Green, 158. Oncologic Emergencies . . . . . . . . . . . . . . . . . . . . . . . . . 2433
Norman E. Breslow, Michael L. Ritchey, John C. Morris, James F. Holland
Patrick R.M. Thomas
Section 43 ONCOLOGY AND THE INFORMATION
c. Germ Cell Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2181
REVOLUTION
Barbara Cushing, Neyssa Marina
d. Neuroblastoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2185 159. Oncology and the Information Revolution . . . . . . . . . . . 2454
Katherine K. Matthay, Darrell J. Yamashiro Edward P. Ambinder
C
ONTRIBUTORS
Stuart A.Aaronson,M.D. Kenneth C.Anderson,M.D.
Professor of Neoplastic Diseases Associate Professor of Medicine
Director Harvard Medical School, Boston, MA
The Derald H. Ruttenberg Cancer Center Medical Director, Kraft Family Blood Donor Center
Mount Sinai Medical Center Dana-Farber Cancer Institute
New York, New York Associate Medical Director
Brigham & Women’s Hospital Blood Bank
James L.Abbruzzese,M.D.,F.A.C.P. Boston, Massachusetts
Professor of Medicine and Chairman
Department of Gastrointestinal Medical Oncology Michael Andreeff,M.D.,Ph.D.
University of Texas MD Anderson Cancer Center Professor of Medicine, Internist
Houston, Texas Stringer Professor for Cancer Treatment and Research
Chief, Section of Molecular Hematology and Therapy
Aviva Abosch,M.D.,Ph.D. Director of Research, Department of Blood and
Epilepsy Research Laboratory Marrow Transplantation
Montreal Neurological Institute University of Texas MD Anderson Cancer Center
Montreal, Quebec, Canada Houston, Texas
Scott I.Abrams,Ph.D. Karen H.Antman,M.D.
Laboratory of Tumor Immunology and Biology Wu Professor of Medicine
National Cancer Institute Chief, Division of Medical Oncology
National Institutes of Health Director, Herbert Irving Comprehensive Cancer Center
Bethesda, Maryland Columbia-Presbyterian Medical Center
New York, New York
David H.Abramson,M.D.
Clinical Professor of Ophthalmology Narin B.Apisarnthanarax,M.D.
Cornell University Medical Center Post-doctoral Research Fellow
Attending Physician Department of Dermatology
Director, Robert M. Ellsworth Ophthalmic University of Texas MD Anderson Cancer Center
Oncology Center Houston, Texas
New York-Presbyterian Hospital
New York, New York Richard Aplenc,M.D.
Children’s Hospital, Oncology Department
George Acs,M.D.,Ph.D. Philadelphia, Pennsylvania
Professor Emeritus
Department of Biochemistry James O.Armitage,M.D.
Mount Sinai School of Medicine Professor and Chairman
New York, New York Department of Internal Medicine
University of Nebraska Medical Center
Sunil Advani,M.D. Omaha, Nebraska
Department of Radiation and Cellular Oncology
University of Chicago Joseph S.Bailes,M.D.
Chicago, Illinois Executive Vice President, Clinical Affairs
US Oncology
Edward P.Ambinder,M.D. Houston, Texas
Associate Clinical Professor of Medicine
Mount Sinai School of Medicine Erik S.Barquist,M.D.,F.A.C.S.
New York, New York Assistant Professor of Surgery