Table Of Content

Cumulative Indexes Volumes 60 — 67 Cancer Letters, 67 (1992) 227 — 253 Elsevier Scientific Publishers Ireland Ltd. Subject Index Volumes 60 — 67 A Adhesion, metastasis, RGD peptides, platelet aggregation, (65) 259 Adnab-9, monoclonal antibody, inflammatory bowel A system, plasma membrane vesicles, alanine transport, disease, (67) 61 kinetic parameters, hepatocarcinogenes, (61) 221 Adriamycin, doxorubicin, anthracycline, [14- 14C)- Aberrant crypts, cholesterol, cell proliferation colon car- doxorubicin, Chinese hamster lung, fibroblast cell cinogenesis 249 lines, V-79 and LZ, (63) 109 AFB,-DNA adduct, geniposide, aflatoxin B,, glutathione Aberrant crypts, flaxseed, lignans, colon carcinogenesis, cell proliferation, (63) 159 S-transferase, -glutamylcysteine synthetase, Aberrant crypts, oxysterols, cholesterol, bile acids, cell hepatotoxicity, (60) 95 proliferation, colon carcinogenesis, (66) 241 AFB, -induced GST-P positive hepatocytes, aflatoxin B,, Acanthopanax giraldii harms, antitumor activity, glutathione S-transferase placental form (GST-P), macrophage activation, C3 cleavage, (65) 74 buthionine sulfoximine (BSO), (66) 249 N-Acetyl-L-cysteine, cigarette smoke, histopathology, Affinity purification, P-glycoprotein, isoquinoline- micronucleus test, bone marrow, pulmonary alveolar sulfonamide, multidrug resistance, H-85, (60) 103 Aflatoxin B,, cytochrome P-450, DNA binding, macrophages, (64) 123 2-Acetylaminofluorene, benzo[a]pyrene, 4-aminobi- glutathione-conjugation, age-related, (66) 69 phenyl, human, rat, hepatocytes, DNA adducts and Aflatoxin, food additives, turmeric, antioxidants, (66) 115 32D _postlabeling assay, (62) 87 Aflatoxin B,, aflatoxin B,-epoxide, aflatoxin By,- Acetylaminofluorene, metabolism, human hepatocytes, DNA binding, (64) 109 glutathione, rat glutatione transferases, (64) 224 Acetylation, hepatoma, differentiation, cytokeratin, Aflatoxin B,, geniposide, glutathione S-transferase, +- phosphorylation, (60) 51 glutamylcysteine synthetase, hepatotoxicity, AFB,- DNA adduct, (60) 95 Actinomycin D reversibility, verapamil, nucleolar protein B23, (60) 221 Aflatoxin B,, geniposide, unscheduled DNA synthesis Acute lymphoid leukemia, acute myeloid leukemia, glutathione S-transferase, glutathione peroxidase, (65) 133 manganese-superoxide dismutase, (62) 211 Acute myeloid leukemia, acute lymphoid leukemia, Aflatoxin B,, glutathione S-transferase placental form manganese-superoxide dismutase, (62) 211 (GST-P), buthionine sulfoximine (BSO), AFB,- N-acyl dehydroalanines, skin carcinogenesis, tumor pro- induced GST-P positive hepatocytes, (66) 249 Aflatoxin B,, penta-acetyl geniposide, genotoxicity, gression, reactive oxygen, (60) 25 Adenocarcinoma, colorectal carcinogenesis, methylchol- cytotoxicity, (62) 233 Aflatoxin B,-epoxide, aflatoxin B,, aflatoxin By,- anthrene, tumors, (61) 177 glutathione, rat glutatione tragsferases, (64) 224 Adenocarcinomas, carcinogenicity, colon, 1,2-dimethylhydrazine, EM 12, rat tumors, teratogenicity, (60) Aflatoxin B,-glutathione, aflatoxin B,, aflatoxin B,- 129 epoxide, rat glutatione transferases, (64) 224 Age-related, aflatoxin B,, cytochrome P-450, DNA Adenoma, mouse, lung, genetics, recombinant inbred strains, (61) 15 Aflatoxin B,, piperine, biotransforma- binding, glutathione-conjugation, (66) 69 tion, DNA binding, (61) 195 Aging, 1,2-diethylhydrazine, carcinogenesis, rats, (67) Adenylate cyclase, beta-adrenergic receptor, GTP- 21 binding proteins, lung epithelial cell lines, growth Aklylating agent, U73-—975, minor groove binders, regulation, (67) 139 combination chemotherapy and modulation, (61) 7 228 Alanine transport, plasma membrane vesicles, A system, Animal model, human T-lymphotropic virus type 1, syn- kinetic parameters, hepatocarcinogenesis, (61) 221 thetic peptide, vaccine, human, (66) 11 Alkylation, gyromitrin, methylation, monomethyl- Antagonists, experimental therapy, WEHI-3B leukemia, hydrazine, N-methylhydrazine, N-7-methylguanine, human xenotransplants, colon cancer, lung cancer, 0° methylguanine, (61) 165 Lewis-lung cancer, platelet activating factor, (67) 145 Alkylation, nitroso-oxopropylamines, nitrosoureas, rats, Anthracenediones, photochemotherapy, B16 hamsters, tumors, (60) 121 melanoma, tumor photosensitization, mitoxantrone, Alliums, esophageal cancer, diallyl sulfide, (64) 39 anti-tumor drugs, (61) 89 S-Allyl cysteine, antitumorigenesis, garlic, neuro- Anthracycline, doxorubicin, Adriamycin, [14- “<- blastoma, (63) 211 doxorubicin, Chinese hamster lung, fibroblast cell Alpha-fetoprotein, glycosylation, hepadnavirus, lines, V-79 and LZ, (63) 109 hepatocellular carcinoma, woodchuck, (63) 93 Antibiotics, polyamine uptake, a-difluoromethyl- Alprazolam, stress, mammary tumor virus, immunity, ornithine, polyamine-deficient diet, antileukemic anxiolytics, (62) 185 effect, (66) 29 Aluminium __ phthalocyanine, photochemotherapy, Antibody dependent cell-mediated cytotoxicity, human murine tumor model, fractionated treatment, (61) monoclonal antibody, anti-cancer antibody, tumor 263 immunity, cytotoxicity, effector cell, (62) 179 Amiloride, estramustine, bleomycin, (64) 171 Antibody-daunomycin conjugate, monoclonal anti- 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline, | Ha-ras bodies, histiocytoma, tumor regression, (64) 163 mutation, forestomach squamous cell carcinoma, (62) Anticancer action, droloxifene (3-hydroxytamoxifen) 115 lipid peroxidation, tamoxifen, membrane antioxidant, (+)-S-2-Amino-5-iodoacetamidopentanoic acid, (+)-S- breast cancer, (66) 61 2-amino-6-iodoacetamidohexanoic acid, lymphosar- Anticarcinogen, testis, steroids, (65) 123 coma, toxicity, polyamines, (67) 193 Anticarcinogens, oral carcinogenesis, diallyl sulfide, y- (+)-S-2-Amino-6-iodoacetamidohexanoic acid, (+)-S- glutamyltranspeptidase, unscheduled DNA synthesis, 2-amino-5-iodoacetamidopentanoic acid, lymphosar- (66) 207 coma, toxicity, polyamines, (67) 193 Antiestrogens, estrogen-induced _ kidney tumors, 2-Amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine, testicular tumors, (64) 23 32P.postlabeling analysis, DNA adducts, colon car- Antileukemic __ effect, polyamine __ uptake, a- cinogenesis, (67) 117 difluoromethylornithine, polyamine-deficient diet, 3-Aminobenzamide, cisplatin resistance, rat ovarian antibiotics, (66) 29 tumor cell line, DNA damage and repair, (67) 27 Antimutagenicity, | polyphenolics, nitrosamine 4- 3-Aminobenzamide, N-nitroso-bis-(2-oxopropyl)amine, (methylnitrosamino)-1-(3 — puridyl) (NNK), car- pancreatic carcinogenesis, Poly(ADP-ribose) poly- cinogenesis, (66) 107 merase, hamster, (61) 61 Antioxidants, aflatoxin, food additives, turmeric, (66) 4-Aminobiphenyl, 2-acetylaminofluorene, benzo[a]- 115 pyrene, human, rat, hepatocytes, DNA adducts and Antioxidants, quercetin, flavonoids, DNA damage, lipid 32D_postlabeling assay, (62) 87 peroxidation, oxygen radicals, (60) 259 4-Aminobiphenyl, aromatic amines, bladder cancer, Antioxidants, quercetin, flavonoids, DNA damage, lipid hemoglobin adducts, (60) 245 peroxidation, oxygen radicals 237 2-Aminofluorene, soybean lipoxygenase, hydroperox- Antioxidants, B-carotene, lycopene, carotenoids, buccal idase, bioactivation, (60) 33 cells, (61) 81 Aminolevulinic acid, photosensitization, endogenous Antiproliferative agents, 21-aminosteroid antioxidant porphyrin, K562 leukemia, (65) 127 (U74500A, U74389F, U78518F), human breast 21-Aminosteroid antioxidant (U74500A, U74389F, cancer cells, mouse lymphoma cells, (64) 61 U78518F), human breast cancer cells, mouse lym Antiproliferative effect, breast cancer cells, melatonin, phoma cells, antiproliferative agents, (64) 61 estrogen response pathway, (64) 249 Ammonia, Helicobacter pylori, gastric cancer, atrophic Antiproliferative effect, transformed cell lines, retinoids, gastritis 15 cytokines, combination therapy, (62) 167 Aneuploidy, breast cancer, C-erbB-2, p53, flow Antitumor activity, 2’-C-cyano-2’-deoxy-1-8-D- cytometry, (66) 193 arabinofuranosylcyto sine (CNDAC), human cancer, Angiogenesis, ovarian cancer, ascitic fluid, macrophages, MTT assay, chick embryo assay, nude mouse assay, endothelial cells, (62) 153 (64) 67 229 Antitumor activity, Acanthopanax iraldii harms, Ascites fluid, ovarian cancer, cathepsin B, proteinase in- macrophage activation, C3 cleavage, (65) 74 hibitors, stefins, cystatins, (61) 243 Antitumor drugs, photochemotherapy, B16 melanoma, Ascitic fluid, ovarian cancer, macrophages, endothelial cells, angiogenesis, (62) 153 tumor photosensitization, mitoxantrone, anthracenediones, (61) 89 Ascorbyl palmitate, curcumin, azoxymethanol, colonic Antitumor promoters, Epstein-Ban virus, epithelial cells, hyperproliferation, focal areas of dihydroagarofuran sesquiterpenes, structural require- dysplasia, (64) 117 ment, (65) 19 Atrophic gastritis Helicobacter pylori, ammonia, gastric Antitumorigenesis, garlic, S-allyl cysteine, neuro- cancer, 15 B16 melanoma, ( — )-epigallocatechin blastoma, (63) 211 gallate, green tea, anti-metastasis, (65) 51 Antitumour activity, mmunomodulatory peptide, tumour Autorcine loop, insulin-like growth factor I, suramin, dif- necrosis, Iscador, Viscum album, (66) 123 ferentiation, human colon cancer cells, (62) 23 Antitumour, chemical carcinogenesis inhibition, Ixora Avidity, anti-phospliatidylinositol antibodies, cellular pro- javanica, (60) 253 liferation, specificity, cancers, hematological diseases, Antitumour, Nigella sativa, Ehrlich ascites carcinoma, (66) 35 Dalton’s lymphoma ascites, Sarcoma-180, (63) 41 Azoxymethane, retinoid, chemoprevention, intestine, Anti-cancer antibody, human monoclonal antibody, anti- rat, (66) 93 body dependent cell-mediated cytotoxicity, tumor im- Azoxymethane, voluntary exercise, rat hepatocar munity, cytotoxicity, effector cell, (62) 179 cinogenesis, (63) 67 Anti-inflammatory drugs, tobacco-specific nitrosamines, Azoxymethane-induced foci, foci of aberrant crypts, rat lung adenoma, (66) 21 colon cancer, chemoprevention, short-term screen, Anti-metastasis, ( — )-epigallocatechin gallate, green tea, (61) 27 B16 melanoma, (65) 51 Azoxymethanol, curcumin, ascorbyl palmitate, colonic Anti-neoplastic agent, phytase, signal transduction, epithelial cells, hyperproliferation, focal areas of phytic acid, (64) 195 dysplasia, (64) 117 Anti-oncogene, tumor promoter, oncogene, cytokeratin, B polymerase chain reaction, hepatoma, (66) 155 Anti-oxidants, cis-unsaturated fatty acids, free radicals, tumor cells, lipid peroxidation, superoxide anion, (63) 189 Anti-phosphatidylinositol antibodies, cellular prolifera- B16 melanoma, photochemotherapy, tumor photosen tion, avidity, specificity, cancers, hematological sitization, mitoxantrone, antitumor drugs, anthracene- diseases, (66) 35 diones, (61) 89 Anti-proliferative signal, interferon-a, tamoxifen, U937 Bacterial glutaminase therapy, Ehrlich ascites tumor, cells, (67) 13 glutamine amidohydrolase, glutamine aminotrans- Anti-tumour necrosis factor-alpha antibodies, cachexia, ferase, mouse liver, mouse plasma, (66) 225 tumour necrosis factor-alpha, interleukin-6, (65) 239 BALB/c 3T3, 1,1,2,2-tetrachloroethane, cell transfor- Anxiolytics, stress, mammary tumor virus, immunity, mation, tetradecanoylphorbol, initiation, promotion, alprazolam, (62) 185 (64) 145 Aphidicolin, neuroblastoma cells, cell killing, (67) 199 BALB/c mice, bromo-2’deoxyuridine, urethan, two- Aqueous extract, pan masala, chromosome abenation, step carcinogenesis, (64) 75 sister chromatid exchange, micronucleus, (65) 221 BaP 7,8-DHD and BPDE metabolism, Chinese medicinal 2’-C-cyano-2’-C-cyano- 1-8-D-Arabinofuranosylcy herbs, Oldenlandia diffusa, Scutellaria barbata, DNA tosine (CNDAC), antitumor activity, human cancer, binding, mutagenesis, scavenging, (62) 123 MTT-assay, chick embryo assay, nude mouse assay, BaP-DNA adducts benzo[a]pyrene, benzo[e]pyrene, (64) 67 cocarcinogenesis, (63) 229 Aromatic amines, bladder cancer, 4-aminobiphenyl, Benzo[a]pyrene, 2-acetylaminofluorene, 4-aminobi- hemoglobin adducts, (60) 245 phenyl, human, rat, hepatocytes, DNA adducts and Arylation, quinones, oxidative stress, cytosolic Ca?*, 32P_postlabeling assay, (62) 87 DNA strand breaks, (63) 47 Benzo[a]pyrene, benzo[e]pyrene, co-carcinogenesis, Asbestos, CD4, CD45RA, (66) 99 BaP-DNA adducts 229 Asbestos, HL-60 cells, cell differentiation, protein kinase Benzo[a]pyrene metabolism, flavonoids, cytochrome P- C, radicals, (62) 225 450, chemoprevention, (60) 15 230 Benzo[b]fluoranthene, metabolic activation, DNA ad- Breast cancer cells, antiproliferative effect, melatonin, ducts, skin, (65) 159 estrogen response pathway, (64) 249 Benzo[e]pyrene, benzo[a]pyrene, co-carcinogenesis, Breast cancer cells, progesterone receptor, estrone BaP-DNA adducts (63) 229 sulfate, estradiol, progestagens, (66) 55 Beta-adrenergic receptor, adenylate cyclase, GTP- Breast carcinoma, ferritin, cytosol, tumour marker, (67) binding proteins, lung epithelial cell lines, growth 103 regulation, (67) 139 Breast diethylstilbestrol (DES), hormone sensitivity, sex Bile acids, oxysterols, cholesterol, aberrant crypts, cell hormones, estrogen, (63) 117 proliferation, colon carcinogenesis, (66) 241 Breast tumors, transgenic mice, oncogenes, salivary Bioactivation, soybean lipoxygenase, 2-aminofluorene, tumors, multifocality, (64) 203 hydroperoxidase, (60) 33 Bromo-2’deoxyuridine, —_urethan, two-step Car- Biotransformation, aflatoxin B,, piperine, DNA binding, cinogenesis, BALB/c mice, (64) 75 (61) 195 5’-Bromodeoxyuridine, lung carcinoma, differentiation, Bladder cancer, aromatic amines, 4-aminobiphenyl, N-myc, (61) 67 hemoglobin adducts, (60) 245 Buccal cells, B-carotene, lycopene, carotenoids, antioxi- Bladder cancer, schistosomiasis, environmental alkylat- dants, (61) 81 ing agents, DNA damage and repair, urinary bacterial Burns, tumorigenicity, cultured keratinocytes, serum-free infection, ras oncogenes, (63) 171 medium, cultured skin grafts, skin carcinoma, (62) Bleomycin, amiloride, estramustine, (64) 171 141 Blood, breast cancer, electrophoresis, fucosyltransferase, Buthionine _sulfoximine, Melanoma, __ tyrosinase, haptoglobins, ovarian cancer, (65) 115 cysteaminylphenol, phenylthiourea, (63) 73 Blood group H-antigen, squamous cell carcinoma, Buthionine sulfoximine (BSO), aflatoxin B,, glutathione glycolipids, papillomavirus, rabbits, (66) 175 S-transferase placental form (GST-P), AFB,-induced Bone marrow, cigarette smoke, histopathology, GST-P positive hepatocytes, (66) 249 micronucleus test, pulmonary alveolar macrophages, N-acetyl-L-cysteine, (64) 123 BOP, cholecystokinin, Syrian golden hanster, pancreatic C neoplasm, DNA aklyation, (62) 251 Brain tumours, N-ethyl-N-nitrourea, rats, nuclear magnetic resonance imaging, magnetic resonance spectroscopy, (67) 125 C3 cleavage, Acanthopanax giraldii harms, antitumor ac- Branched-chain amino acids, cancer, cachexia, leucine, tivity, macrophage activation, (65) 74 rat, (61) 239 C-fes tryrosine protein kinase, differentiation, colony Breast cancer, C-erbB-2, p53, aneuploidy, flow stimulating factor, GM-CSF, phosphorylation, (63) 15 cytometry, (66) 193 C3H/10T1/2, proliferin, tumour promoter, molecular Breast, conjugated linoleic acid (CLA), (-carotene, marker, (64) 1 melanoma, colorectal, cancer cells, (63) 125 CA19-9, colonic effluent, monoclonal antibody, (60) 9 Breast, a-D-galactose, cancer, (60) 59 Cachexia, cancer, branched-chain amino acids, leucine, Breast cancer, interferon-y, indoleamine-2,3- rat, (61) 239 dioxygenase, gynecologic cancer, tumor marker, (66) Cachexia, tumour necrosis factor-alpha, interleukin-6, 77 anti-tumour necrosis factor-alpha antibodies, (65) 239 Breast cancer, blood, electrophoresis, fucosyltransferase, Calcium, growth factors, breast cancer, (66) 131 haptoglobins, ovarian cancer, (65) 115 Cancer, branched-chain amino acids, cachexia, leucine, Breast cancer, calcium, growth factors, (66) 131 rat, (61) 239 Breast cancer, droloxifene (3-hydroxytamoxifen) lipid Cancer, T-lymphocytes, pancreas, hamster, pretumoral peroxidation, tamoxifen, membrane antioxidant, anti- stages, immunesurveillance, (67) 79 cancer action, (66) 61 Cancer, vanadium, neoplastic transformation, tumor Breast cancer, oestrogen, progesterone, p29, cathepsin promotion, carcinogenesis, (64) 83 D, enzyme immunoassay, steroid binding assay, (66) Cancer, a-D-galactose, breast, (60) 59 183 Cancer cells, conjugated linoleic acid (CLA), B-carotene, Breast cancer, placental isoferritin, differentiation, (67) melanoma, colorectal, breast, (63) 125 35 Cancers, anti-phosphatidylinositol antibodies, cellular proliferation, avidity, specificity, hematological Cathepsin D, laryngeal cancer, (67) 133 diseases, (66) 35 CBA/Ca mice, cytostatic protocols, sister chromatid ex- Canine mycosis fungoides, linoleate therapy, (64) 17 changes (SCE), micronuceli, genotoxicity, (60) 199 Canthaxanthin, inhibition, tumor growth, transformed CD4, CD45RA, asbestos, (66) 99 and non-transformed cells, (65) 209 CD45RA, CD4, asbestos, (66) 99 Carbaryl, mouse skin, carcinogenicity, cocarcinogenicity, CD4~ carcinoma cell lines, HIV-1 infectivity, HIV-HPV (62) 133 coinfection, (63) 23 Carbohydrate, fucose, haptoglobin, ovarian cancer, (66) cDNA, laminin, receptor, human, lung cancer, (62) 199 43 Cell adhesion, carcinoembryonic antigen, colorectal Carcinoembryonic antigen, cell adhesion, colorectal cancer, (60) 143 cancer, (60) 143 Cell cycle, oncogenes, mastocytes, interleukin-3, flow Carcinoembryonic antigen, monoclonal antibody, cytometry, (62) 243 colonic effluent, (67) 47 Cell death, monoclonal, tumor origin, polyclonal, Monte Carcinogenesis, 1,2-diethylhydrazine, aging, rats, (67) 21 Carlo, (60) 113 Carcinogenesis, antimutagenicity, polyphenolics, Cell differentiation, HL-60 cells, protein kinase C, nitrosamine 4-(methylnitrosamino)-1-(3 _ puridyl) radicals, asbestos, (62) 225 (NNK), (66) 107 Cell killing, aphidicolin, neuroblastoma cells, (67) 199 Carcinogenesis, diethylstilbestrol, mice, prenatal, Cell migration, protein kinase C, glioma, (63) 167 hypothalamus, (67) 55 Cell proliferation, cholesterol, aberrant crypts, colon car- Carcinogenesis, multihit model, doubly-hit cells, (64) 91 cinogenesis, (63) 249 Carcinogenesis, trypsin inhibitor, pancreas, hamster, Cell proliferation, dimethylhydrazine, colon tumori- lorglumide, (60) 205 genesis, iron concentration, malonaldehyde, oxida- Carcinogenesis, ultraviolet, N-methyl-N’-nitro-N-nitro- tive stress, (65) 245 soguanidi ne, modulation, (61) 135 Cell proliferation, flaxseed, lignans, colon carcino- Carcinogenesi, upper aero-digestive tract, oral, multiple genesis, aberrant crypts, (63) 159 cancers, epidemiology, risk factors, (60) 1 Cell proliferation, flaxseed, lignans, mammary carcino- Carcinogenesis, vanadium, cancer, neoplastic transfor- genesis, nuclear aberration, (60) 135 mation, tumor promotion, (64) 83 Cell proliferation, oxysterols, cholesterol, bile acids, aber- Carcinogenesis, N-methyl-N-nitrosourea, colon tumors, rant crypts, colon carcinogenesis, (66) 241 oncogenes, transfection, (61) 119 Cell transformation, 1,1,2,2-tetrachloroethane, BALB/c Carcinogenic nitrosamines, sulphur compounds, nitrosa- 3T3, tetradecanoylphorbol, initiation, promotion, tion, inhibition, (65) 227 (64) 145 Carcinogenicity, | adenocarcinomas, colon, — 1,2- Cellular cholesterol content, hyperthermic sensitivity, dimethylhydrazine, EM 12, rat tumors, teratogenicity, cholesterol content modification, (60) 159 (60) 129 Cellular proliferation, anti-phosphatidylinositol anti- Carcinogenicity, carbaryl, mouse skin, cocarcinogenicity, bodies, avidity, specificity, cancers, hematological (62) 133 diseases, (66) 35 Carcinogenicity in rats, dinaline, reduced incidence of Cellulose, diet, neoplasia, organochlorines, reproduc- malignancies, hormone-dependent neoplasms, (60) tion, promotions, (63) 83 237 Cervical carcinogenesis, medroxyprogesterone acetate, B-Carotene, conjugated linoleic acid (CLA), melanoma, methylcholanthrene, cervix, (61) 187 colorectal, breast, cancer cells, (63) 125 Cervical carcinoma, homozygosity chromosome 17, (63) B-Carotene, lycopene, carotenoids, antioxidants, buccal 243 cells, (61) 81 Cervix, medroxyprogesterone acetate, cervical car- Carotenoids, B-carotene, lycopene, antioxidants, buccal cinogenesis, methylcholanthrene, (61) 187 cells, (61) 81 Chalcones, luteolin, flavonoids, growth inhibition, ~~. NMR, *'P-NMR, (67) 207 Cashew nut shell oil, papilloma, mouse skin, (62) 149 Castanospermine, platelet aggregation, metastasis, (60) Characterization, 20-methylcholanthrene transforma- 185 tion, development, murine fibroblast, (67) 1 Cathepsin B, ovarian cancer, ascites fluid, proteinase in- Chemical carcinogenesis inhibition, antitumour, Ixora hibitors, stefins, cystatins, (61) 243 javanica, (60) 253 Cathepsin D, breast cancer, oestrogen, progesterone, Chemoprevention, benzo[a]pyrene metabolism, p29, enzyme immunoassay, steroid binding assay, flavonoids, cytochrome P-450, (60) 15 (66) 183 Chemoprevention, foci of aberrant crypts, rat colon 232 cancer, azoxymethane-induced foci, short-term Cocarcinogenicity, carbaryl, mouse skin, carcinogenicity, screen, (61) 27 (62) 133 Chemoprevention, retinoid, azoxymethane, intestine, Collateral sensitivity, thaliblastine, cisplatin resistance, rat rat, (66) 93 ovarian tumor cell lines, (62) 173 Chemoprevention, N-nitrosodimethylamine, ellagic acid, Colloidal gold, mouse mammary tumor virus, long ter- cytochrome P-450]IE1, metabolism, mutagenicity, minal repeat, open reading frame, monoclonal anti- (61) 129 body, (65) 201 Chick embryo assay, 2’-C-cyano-2’-deoxy-1-8-D- Colon, adenocarcinomas, carcinogenicity, 1,2- arabinofuranosylcyto sine (CNDAC), antitumor activ- dimethylhydrazine, EM 12, rat tumors, teratogenicity, ity, human cancer, MTT-assay, nude mouse assay, (60) 129 (64) 67 Colon, c-myc, oncogene, proto-oncogene, induction Chinese hamster lung, doxorubicin, Adriamycin, an- and differentiation agents, (62) 95 thracycline, [14-!4C]doxorubicin, fibroblast cell lines, Colon cancer, colon suppression, protease inhibitors, V-79 and LZ, (63) 109 (63) 135 Chinese medicinal herbs, Oldenlandia diffusa, Scutellaria Colon cancer, differentiation, TGF-8, sodium butyrate, barbata, BaP 7,8-DHD and BPDE metabolism, DNA growth inhibition, (63) 33 binding, mutagenesis, scavenging, (62) 123 Colon cancer, platelet activating factor, antagonists, Chloride current, multidrug resistance, intracellular pH, experimental therapy, WEHI-3B leukemia, human (66) 83 xenotransplants, lung cancer, Lewis-lung carcinoma, Chlorination by-products, trichloroacetonitrile, (67) 145 halogenated acetonitriles, DNA adduct, protein ad- Colon carcinogenesis, 2-amino-1-methyl-6-phenylimi- duct, (62) 1 dazo[4,5-b]pyridine, °*P-postlabeling analysis, DNA Cholecystokinin, Syrian golden hanster, pancreatic adducts, (67) 117 neoplasm, DNA aklyation, BOP, (62) 251 Colon carcinogenesis, dietary fat, tumor initiation, Cholesterol, aberrant crypts, cell proliferation, colon dimethylhydrazine, (67) 87 carcinogenesis, (63) 249 Colon carcinogenesis, flaxseed, lignans, aberrant crypts, Cholesterol, human gliomas, human meningioma, lipid, cell proliferation, (63) 159 phosphoglyceride, (65) 169 Colon carcinogenesis, oxysterols, cholesterol, bile acids, Cholesterol, oxysterols, bile acids, aberrant crypts, cell aberrant crypts, cell proliferation, (66) 241 proliferation, colon carcinogenesis, (66) 241 Colon carcinogenesis cholesterol, aberrant crypts, cell Cholesterol content modification, hyperthermic sensitiv- proliferation, (63) 249 ity, cellular cholesterol content, (60) 159 Colon suppression, colon cancer, protease inhibitors, Chromosome 17, homozygosity cervical carcinoma, (63) (63) 135 243 Colon tumorigenesis, dimethylhydrazine, iron concentra- Chromosome abenation, pan masala, sister chromatid tion, malonaldehyde, cell proliferation, oxidative exchange, micronucleus, aqueous extract, (65) 221 stress, (65) 24 Cigarette smoke, histopathology, micronucleus test, Colon tumors, N-methyl-N-nitrosourea, oncogenes, bone marrow, pulmonary alveolar macrophages, N- transfection, carcinogenesis, (61) 119 acetyl-L-cysteine, (64) 123 Colonic effluent, CA19-9, monoclonal antibody, (60) 9 Circumvention, multidrug resistance, vitamin K3, drug Colonic effluent, carcinoembryonic antigen, monoclonal transport, DNA binding, (61) 147 antibody, (67) 47 Cisplatin, Harvey-ras gene, DNA _ transfection, Colonic epithelial cells, curcumin, ascorbyl palmitate, polymerase chain reaction, DNA sequencing, (65) 27 azoxymethanol, hyperproliferation, focal areas of Cisplatin, hematoxicity, procaine, (64) 55 dysplasia, (64) 117 Cisplatin, leukocytes, pRSVcat, electroporation, DNA Colony stimulating factor, tryrosine protein kinase, differ- repair, (63) 143 entiation, GM-CSF, phosphorylation, c-fes 15 Cisplatin resistance, rat ovarian tumor cell line, DNA Colorectal, conjugated linoleic acid (CLA), B-carotene, damage and repair, 3-aminobenzamide, (67) 27 melanoma, breast, cancer cells, (63) 125 Cisplatin resistance, thaliblastine, collateral sensitivity, rat Colorectal cancer, carcinoembryonic antigen, cell adhe- ovarian tumor cell lines, (62) 173 sion, (60) 143 Cis-unsaturated fatty acids, free radicals, tumor cells, Colorectal carcinogenesis, methylcholanthrene, tumors, lipid peroxidation, superoxide anion, antioxidants, adenocarcinoma, (61) 177 (63) 189 Colorectal carcinoma, IMU, seroepidemiology, (65) 233 Clove, detoxifying enzymes, modulation, mouse liver, Colorectal carcinoma, transglutaminase, neoplasm (60) 67 metastasis, (60) 85 233 Combination chemotherapy and modulation, dependent cell-mediated cytotoxicity, anti-cancer U73-—975, minor groove binders, aklylating agent, antibody, tumor immunity, effector cell, (62) 179 (61) 7 Cytotoxicity, malachite green, morphological alterations, Combination therapy, antiproliferative effect, trans- free radical formation, hydroxymethyl radicals, Syrian formed cell lines, retinoids, cytokines, (62) 167 hamster embryo cells, (67) 93 Compensatory regeneration, direct hyperpalsia, platelet- Cytotoxicity, penta-acetyl geniposide, genotoxicity, afla- poor plasma, hepatocytes, (61) 233 toxin B,, (62) 233 Complete carcinogenesis, retinoic acid, retinoids, skin C-erbB-2, breast cancer, p53, aneuploidy, flow tumorigenesis, two-stage carcinogenesis, (66) 233 cytometry, (66) 193 Conjugated linoleic acid (CLA), B-carotene, melanoma, C-erbB-2/neu(HER-2), oncogenes, oral carcinoma, im- colorectal, breast, cancer cells, (63) 125 munohistochemisty, (65) 215 Co-carcinogenesis, benzo[a]pyrene, benzo[e]pyrene, C-erbB-2/neu, HER-2, oncogene, ovarian cancer, (61) BaP-DNA adducts 229 95 Cultured keratinocytes, tumorigenicity, serum-free C-ets-1 protooncogene, rat embryo fibroblasts, immor- medium, cultured skin grafts, burns, skin carcinoma, talization, transformation, (67) 71 (62) 141 C-fgr, Epstein-Barr virus, immortalization, (64) 11 Cultured skin grafts, tumorigenicity, cultured c-myc, colon, oncogene, proto-oncogene, induction and keratinocytes, serum-free medium, burns, skin car- differentiation agents, (62) 95 cinoma, (62) 141 Curcumin, ascorbyl palmitate, azoxymethanol, colonic epithelial cells, hyperproliferation, focal areas of D dysplasia, (64) 117 Cystatins, ovarian cancer, ascites fluid, cathepsin B, proteinase inhibitors, stefins, (61) 243 Cysteaminylphenol, Melanoma, tyrosinase, buthionine Dalton’s lymphoma ascites, antitumour, Nigella sativa, sulfoximine, phenylthiourea, (63) 73 Ehrlich ascites carcinoma, Sarcoma-180, (63) 41 Cysteine, gluthathione, methotrexate uptake, 2’-Deoxyguanosine, 1-8-D-arabinofuranosylcytrosine, thymocytes, thymic lymphosarcoma cells, (65) 251 hydroxyurea, gastric carcinoma, drug combination, Cytochrome P-450, benzo[a]pyrene metabolism, (63) 221 flavonoids, chemoprevention, (60) 15 Detoxifying enzymes, clove, modulation, mouse liver, Cytochrome P-450, aflatoxin B,, DNA _ binding, (60) 67 glutathione-conjugation, age-related, (66) 69 Development, 20-methylcholanthrene transformation, Cytochrome P-450, dibenzo[a,e]fluoranthene, DNA ad- characterization, murine fibroblast, (67) 1 ducts, fibroblasts, (61) 207 Diallyl sulfide, alliums, esophageal cancer, (64) 39 Cytochrome P-450IIE1, N-nitrosodimethylamine, ellagic Diallyl sulfide, oral carcinogenesis, anticarcinogens, t- acid, metabolism, chemoprevention, mutagenicity, glutamyltranspeptidase, unscheduled DNA synthesis, (61) 129 (66) 207 Cytokeratin, hepatoma, differentiation, phosphorylation, Dibenzo[a,e]fluoranthene, DNA adducts, fibroblasts, acetylation, (60) 51 cytochrome P-450, (61) 207 Cytokeratin, tumor promoter, oncogene, anti-oncogene, Diet, cellulose, neoplasia, organochlorines, reproduc- polymerase chain reaction, hepatoma, (66) 155 tion, promotion, (63) 83 Cytokines, antiproliferative effect, transformed cell lines, Dietary components, fecapentaenes, fecal mutagenicity, retinoids, combination therapy, (62) 167 vegetarians, omnivores, (62) 11 Cytokines, tumor necrosis factor, tamoxifen, MCF-7 Dietary fat, tumor initiation, colon carcinogenesis, cells, synergism, inducible mRNA’s, interferons, (61) dimethylhydrazine, (67) 87 45 Dietary nitrate, piperazine, endogenous formation of N- Cytosol, ferritin, breast carcinoma, tumour marker, (67) nitrosomonopiperazine and N,N’ dinitrosopiperazine* 103 139 Cytosolic Ca?*, quinones, oxidative stress, arylation, Dietary nitrate burden, salivary nitrate/nitrite, high risk DNA strand breaks, (63) 47 area, population study, endogenous nitrosation, (64) Cytostatic protocols, sister chromatid exchanges (SCE), 133 micronuceli, CBA/Ca mice, genotoxicity, (60) 199 Diethylstilbestrol, mice, prenatal, carcinogenesis, Cytotoxic effect, HeLa, Raji, flavonoids, polyphenols, hypothalamus, (67) 55 fat-soluble vitamins, (62) 217 Differentiation, breast cancer, placental isoferritin, (67) Cytotoxicity, human monoclonal antibody, antibody 35 234 Differentiation, hepatoma, cytokeratin, phosphorylation, Diode lasers, photodynamic therapy, tumours, acetylation, (60) 51 naphthalocyanines, pharmacokinetics, (65) 145 Dfferentiation, insulin-like growth factor I, suramin, Direct hyperpalsia, compensatory regeneration, platelet- autorcine loop, human colon cancer cells, (62) 23 poor plasma, hepatocytes, (61) 233 Differentiation, lung carcinoma, 5’-bromodeoxyuridine, Distribution, naticarcinogenesis, protease inhibitor, (62) 191 N-myc, (61) 67 Differentiation, neuroblastoma, laminin, retinoic acid, DNA adduct, engine oil, *"P-postlabelling analysis, (64) (64) 31 137 Differentiation, TGF-8, sodium butyrate, colon cancer, DNA adduct, trichloroacetonitrile, halogenated aceto- growth inhibition, (63) 33 nitriles, chlorination by-products, protein adduct, (62) Differentiation, transactivation, monocytes, HIV-LTR, 1 promoter/enhancer, (60) 75 DNA _ adducts, 2-amino-1-methyl-6-phenylimidazo- Differentiation, tryrosine protein kinase, colony [4,5-b]pyridine, **P-postlabeling analysis, colon stimulating factor, GM-CSF, phosphorylation, c-fes, carcinogenesis, (67) 117 (63) 15DNA damage, quercetin, antioxidants, DNA adducts, benzo[b]fluoranthene, metabolic activation, skin, (65) 159 flavonoids, lipid peroxidation, oxygen radicals, (63) 237 DNA adducts, dibenzo[a,e]fluoranthene, fibroblasts, Dihydroagarofuran sesquiterpenes, Epstein-Ban virus, cytochrome P-450, (61) 207 antitumor promoters, structural requirement, (65) 19 DNA adducts, polycyclic aromatic hydrocarbons, *2P- 1,25-Dihydroxyvitamin D3, glyceraldehyde-3-phosphate postlabeling assay, (65) 35 dehydrogenase, malignant human mammary cell DNA adducts and *P-postlabeling assay, 2-acetyl- lines, (64) 219 aminofluorene, benzo[a]pyrene, 4-aminobiphenyl, a-Difluoromethylornithine, a-polyamines, hormone- human, rat, hepatocytes, (62) 87 dependent and -independent breast cancer, (66) 1 DNA aklyation, cholecystokinin, Syrian golden hanster, a-Difluoromethylornithine, polyamine uptake, poly- pancreatic neoplasm, BOP, (62) 251 amine-deficient diet, antibiotics, antileukemic effect, DNA binding, acetylaminofluorene, metabolism, human (66) 29 hepatocytes, (64) 109 a-difluoromethylornithine, transplacental carcinogenesis, DNA binding, aflatoxin B,, cytochrome P-450, rats, vitamins, sodium selenite, (60) 177 glutathione-conjugation, age-related, (66) 69 9,10-Dimethyl-1,2-benzanthracene, prostaglandin oligo- DNA binding, aflatoxin B,, piperine, biotransformation, meric derivatives, lingual carcinoma, inhibitory effect, (61) 195 hamster, (61) 171 DNA binding, Chinese medicinal herbs, Oldenlandia dif- Dimethylbenz[aJanthracene, hamsters, golden Syrian, fusa, Scutellaria barbata, BaP 7,8-DHD and BPDE glutathione transferase, (64) 241 metabolism, mutagenesis, scavenging, (62) 123 7,12-Dimethylbenz[aJanthracene-DNA adducts, rose DNA binding, multidrug resistance, circumvention, mary extract, mammary tumorigenesis, (60) 169 vitamin K3, drug transport, (61) 147 7,12-Dimethylbenzanthracene, protein A, tumour initia- DNA damage, quercetin, antioxidants, flavonoids, lipid tion, mouse skin, (61) 105 peroxidation, oxygen radicals, (60) 259 1,2-Dimethylhydrazine, adenocarcinomas, carcinogeni- DNA damage and repair, cisplatin resistance, rat ovarian city, colon, EM 12, rat tumors, teratogenicity, (60) tumor cell line, 3-aminobenzamide, (67) 27 129 DNA damage and repair, schistosomiasis, bladder 1,2-Diethylhydrazine, carcinogenesis, aging, rats, (67) cancer, environmental alkylating agents, urinary 21 bacterial infection, ras oncogenes, (63) 171 Dimethylhydrazine, colon tumorigenesis, iron concentra- DNA _ methylation, X-ray, mouse m5S/1M_ cell, tion, malonaldehyde, cell proliferation, oxidative tumorigenic transformation in vitro, protooncogenes, stress, (65) 245 (67) 157 Dimethylhydrazine, dietary fat, tumor initiation, colon DNA repair, cisplatin, leukocytes, pRSVcat, electropora- carcinogenesis, (67) 87 tion, (63) 143 Dinaline, carcinogenicity in rats, reduced incidence of DNA sequencing, Harvey-ras gene, cisplatin, DNA malignancies, hormone-dependent neoplasms, (60) transfection, polymerase chain reaction, (65) 27 237 DNA strand breaks, quinones, oxidative stress, arylation, Dintropyrene, nitrosopyrene, nitroreduction, (65) 73 cytosolic Ca?*, (63) 47