Cancer and Pregnancy PDF
Preview Cancer and Pregnancy
Cancer and Pregnancy Springer London Berlin Heidelberg New York Barcelona Hong Kong Milan Paris Singapore Tokyo Eytan R. Barnea, Eric Ja uniaux and Peter E. Schwartz (Eds) Cancer and Pregnancy Springer Eytan R. Barnea, MD, FACOG Society for the Investigation of Early Pregnancy, 1697 Lark Lane, Cherry Hill, NJ 08003-3157, USA Eric Ja uniaux, MD, PhD Department of Obstetric and Gynaecology, University College London Medical School, 86-96 Chenies Mews, London, WC1E 6HX Peter E. Schwartz, MD, FA COG Department of Obstetrics and Gynaecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA British Library Cataloguing in Publication Data Cancer and pregnancy 1. Cancer in pregnancy I. Barnea, E. R. II. Jauniaux, E. III. Schwartz, Peter E. 618.3 ISBN-13:978-1-4471-1184-9 Library of Congress Cataloging-in-Publication Data Cancer and pregnancy Cancer in pregnancy 1 Eytan R. Barnea, Eric Jauniaux and Peter E. Schwartz (eds.). p.;cm Includes bibliographical references and index. ISBN-13:978-1-4471-1184-9 e-ISBN -i3: 978-1-4471-0707-1 DOI:I 0.1007/978-1-4471-0707-1 1. Cancer in pregnancy. 2. Pregnancy-Complications. I. Barnea, E. R. II. Jauniaux, E. III. Schwartz, Peter E. [DNLM: 1. Pregnancy Complications, Neoplastic. WQ 240 C2147 2001] RG580.C3 C35 2001 618.3-dc21 00-049240 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms oflicences issued by the Copyright Licensing Agency. Enquiries concerning reproduaion outside those terms should be sent to the publishers. ISBN-13:978-1-4471-1184-9 Springer-Verlag London Berlin Heidelberg a member of BertelsmannSpringer Science+Business Media GmbH http://www.springer.co. uk © Springer-Verlag London Limited 2001 Softcover reprint of the hardcover 1st edition 2001 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Typeset by Bookcraft Ltd, Stroud, Gloucestershire 28/3830-543210 Printed on acid-free paper SPIN 10779570 Contents PART I: CLINICAL ASPECTS: DIAGNOSIS AND MANAGEMENT 1 The Epidemiology of Cancer in Pregnancy T. Dinh and D. Warshal ......................................... . 2 Placental and Fetal Cancers E. /auniaux, Y. Gillerot and /. Hustin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3 Breast Cancer and Pregnancy E. Shah and C. Saunders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 4 Gynaecologic Malignancies in Pregnancy M.L. Anderson, G. Mari and P.E. Schwartz. . . . . . . . . . . . . . . . . . . . . . . . . . 33 5 Hematologic Malignancies in Pregnancy T. Pejovic, P.E. Schwartz and G. Mari. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 6 Melanoma in Pregnancy S.P. Harlow..................................................... 54 7 Rare Tumours in Pregnancy T. Pejovic, G. Mari and P.E. Schwartz. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 8 Coloredal-(ancer in Pregnancy S.M. Stemmer................................................... 76 9 Radiologic Diagnosis of Cancer in Pregnancy K. Odunsi, P.E. Schwartz and G. Mari. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 10 Pregnancy Derived Tumor Marker T. Maruo and T. Otani . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 11 Chemo and Radiation Therapy During Pregnancy M. Muslim, /. Goldberg and A. Hageboutros . . . . . . . . . . . . . . . . . . . . . . . . . 108 12 Management of Cancer in Pregnancy (Case Reports) M.L. Anderson and G. Mari, P.E. Schwartz. . . . . . . . . . . . . . . . . . . . . . . . .. 119 13 Transplacental Carcinogenesis: Role of Chemicals, Radiation and Viruses o. Diav-Citrin, A. Ornoy and R. K. Miller. . . . . . . . . . . . . . . . . . . . . . . . . . .. 131 PART II COMPARATIVE ASPECTS OF PREGNANCY DEVELOPMENT AND TUMOUR BIOLOGY 14 Metabolism of Chemotherapeutic Drugs by Maternal and Conceptus Tissues M.K. Sanyal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 149 15 Adverse Reproductive Outcome Potential of Cancer Therapies During Pregnancy M.K. Sanyal.................................................... 174 16 Immunomodulatory Analogies Between Trophoblastic and Cancer Cells and Their Hosts e.B. Coulam and D. Rukavina. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 190 17 Protective Role of Human Chorionic Gonadotrophin and Luteinizing Hormone Against Breast Cancer Z.M. Lei and Ch. V. Rao . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 209 18 Proliferation, Differentiation and Apoptosis in Pregnancy and Cancer R.G. Lea. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 216 19 Controlled vs Uncontrolled Angiogenesis: Color Doppler Studies A. Kurjak, S. Kupesic and T. Zodan. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 229 20 Angiogenesis and Vasculogenesis in Pregnancy and in Tumor Development M.Zygmunt.................................................... 251 21 Trophoblast Implantation Versus Tumor Invasion o. R. Foulk and Genbacev. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 267 22 Pregnancy Derived Compounds that Control Proliferation E.R. Barnea, G. Aboagye-Mathiesen, W.e. Hatch and P.e. Leavis . . . . . . . .. 277 23 Cancer and Pregnancy: Bioethical and Legal Dilemmas F.A. Chervenak and I.B. McCullough. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 287 Epilogue Cancer and Pregnancy: a Reason for Hope E.R. Barnea .................................................... 298 Index 303 Contributors George Aboagye-Mathiesen, PhD Tuan A Dinh, MD Institute of Medical Biochemistry Departmenet of Obstetrics and Gynecology University of Aarhus Cooper Hospital! University Medical Center Ole Worms Alle, Building 170 1 Cooper Plaza, suite 623 8000 Aarhus C, Denmark Camden NJ 08103, USA Matthew L. Anderson, MD, PhD Russell Foulk, MD, FACOG Department of Obstetrics and Gynecology University of Nevada School of Medicine and Divisions of Maternal-Fetal Medicine Medical Director Yale University School of Medicine The Nevada and Idaho Center for New Haven, Connecticut USA Reproductive Medicine 6630 S. McCarran Blvd, Suite 9 Eytan R. Barnea, MD, FACOG Reno, NV 89509, USA Chairman The Society for the Investigation of Early Olga Genbacev, PhD Pregnancy (SIEP) Department of Stomatology 1697 Lark Lane University of California, San Francisco Cherry Hill, NJ 08003-3157, USA 513 Parnassus Avenue HSW 604 San Francisco, CA 94143-0512, USA Frank A. Chervenak, MD Professor and Acting Chairman Yves Gillerot, MD, PhD Department of Obstetrics and Gynecology Institut de Morphologie New York Weill Cornell Medical Center Pathologique Loverval (IMPL) 525 East 68th Street, Room J130 Allee des Templiers 41 New York, NY 10021, USA 6280 Gerpinnes (Loveral), Belgium Carolyn B. Coulam, MD Jack Goldberg, MD Sher Institute for Reproductive Medicine of Department of Medicine Chicago Division of Hematology/Medical Oncology 233 E Erie, Suite 500 Cooper Hospital/University Medical Center Chicago, IL 60611, USA 3 Cooper Plaza, Suite 220 Camden, NJ 08103, USA Orna Diav-Citrin, MD Department of Pediatrics The Hebrew University Hadassah Medical School P.O. Box 12272 Jerusalem 91120, Israel vii viii Cancer and Pregnancy Alexandre Hageboutros, MD Paul C. Leavis, PhD Department of Medicine Boston Biomedical Research Institute Division of Hematology/Medical Oncology 64 Grove Street Cooper Hospital/University Medical Center Watertown, MA 02472-2829, USA 3 Cooper Plaza, Suite 220 Camden, NJ 08103, USA Z. M. Lei, PhD Division of Basic Science Research Seth P. Harlow, MD Department of Obstetrics and Gynecology Assistant Professor of Surgery University of Louisville Health Sciences Division of Surgical Oncology Center University of Vermont Louisville, Kentucky, USA Given Building, Room 309 Burlington, VT 05405, USA Giancarlo Mari, MD Department of Obstetrics and Gynecology William C. Hatch, PhD and Divisions of Maternal-Fetal Medicine Boston Biomedical Research Institute Yale University School of Medicine 64 Grove Street New Haven, Connecticut, USA Watertown, MA 02472-2829, USA Takeshi Maruo, MD Jean Hustin, MD, PhD Department of Obstetrics and Gynecology Institut de Morphologie Kobe University School of Medicine Pathologique Loverval (IMPL) Kusunoki-Cho, Chuo-Ku Allee des Templiers 41 Kobe 650-0017, Japan 6280 Gerpinnes (Loveral), Belgium Laurence B. McCullough, PhD Eric Jauniaux, MD, PhD Professor of Medicine and Medical Ethics Reader in Obstetrics and Maternofoetal Center for Medical Ethics and Health Policy Medicine Baylor College of Medicine Academic Departments of Obstetrics and 1 Baylor Plaza Gynaecology Houston, TX 77030, USA University College London Medical School 86-96 Chenies Mews Richard K. Miller, PhD London WClE 6HX, UK Professor and Director Department of Obstetrics and Gynecology Sanja Kupesic, MD, PhD Division of Research/PEDECS Department of Obstetrics and Gynecology University of Rochester Medical Center Medical School University of Zagreb 601 Elmwood Avenue, Box 668 Sveti Duh Jospital Rochester, NY 14642-8668, USA SvetiDuh 64 10000 Zagreb, Croatia Muhammad Muslim, MD Department of Medicine Asim Kurjak, MD, PhD Division of Hematology/Medical Oncology Department of Obstetrics and Gynecology Cooper Hospital, University Medical Center Medical School University of Zagreb 3 Cooper Plaza, Suite 220 Sveti Duh Jospital Camden NJ 08103, USA Sveti Duh 64 10000 Zagreb, Croatia Kunle Odunsi, MD, PhD Department of Gynecological Oncology Richard G. Lea, PhD Roswell Park Cancer Institute Senior Research Scientist Elm and Carlton Streets Division of Nutrition and Development Buffalo, NY 14263, USA The Rowett Research Institute Greenburn Road, Bucksburn Aberdeen AB21 9SB, UK Contributors ix Asher Ornoy, MD Christobel Saunders, FRCS Department of Anatomy and Cell Biology Department of Surgery The Hebrew University Charles Bell House Hadassah Medical School Riding House Street P.O. Box 12272 London, UK Jerusalem 91120, Israel Elizabeth F. Shah, MSc, FRCS Tetsuo Otani, MD Department of Surgery Department of Obstetrics and Gynecology Charles Bell House Kobe University School of Medicine Riding House Street Kusunoki-Cho, Chuo-Ku London, UK Kobe 650-0017, Japan Peter E. Schwartz, MD, FACOG Tanja Pejovic, MD, PhD Vice Chair/Director of Gynecologic Department of Obstetrics and Gynecology Oncology Yale University School of Medicine Department of Obstetrics and Gynecology 333 Cedar Street Yale University School of Medicine New Haven, CT 06520, USA 333 Cedar Street New Haven, CT 06510, USA Ch. V. Rao, PhD Division of Basic Science Research Shlomo Marc Stemmer, MD, MS, FACOG Department of Obstetrics and Gynecology Crispin Square University of Louisville Health Sciences 230 N Maple Ave Center Marlton, NJ 08053, USA 438 Medical-Dental Building 511 South Floyd Street David P. Warshal, MD Louisville, KY 40292, USA Department of Obstetrics and Gynecology Cooper Hospital! University Medical Center Daniel Rukavina, MD, DSc 3 Cooper Plaza, suite 221 Professor and Chairman Camden, NJ 08103, USA Department of Physiology and Immunology Medical Faculty, University of Rijeka Tina Zodan, MD B. Branchetta 20 Opca Bolnica 51000 Rijeka, Croatia SvetiDuh64 10000 Zagreb, Croatia Mrinal K. Sanyal, PhD Departments of Obstetrics and Gynecology and Marek Zygmunt, MD Molecular, Cellular and Developmental Biology Department of Obstetrics and Gynecology Yale University School of Medicine University of Giessen 333 Cedar Street Klinikstr.32 New Haven, CT 06510, USA Giessen, 35385, Germany Part I Clinical Aspects: Diagnosis and Management
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