Cancer and IgE: Introducing the Concept of AllergoOncology PDF
Preview Cancer and IgE: Introducing the Concept of AllergoOncology
Manuel L. Penichet, Erika Jensen-Jarolim Editors Cancer and IgE Introducing the Concept of AllergoOncology Cancer and IgE · Manuel L. Penichet Erika Jensen-Jarolim Editors Cancer and IgE Introducing the Concept of AllergoOncology Editors ManuelL.Penichet ErikaJensen-Jarolim AssociateProfessor ProfessorandChair DivisionofSurgicalOncology, DepartmentofPathophysiology DepartmentofSurgery, CenterofPathophysiology,Infectiology andDepartmentofMicrobiology, andImmunologyMedicalUniversity ofViennaWaehringerG.18-20, Immunology,andMolecularGenetics 1090Vienna,Austria DavidGeffenSchoolofMedicine [email protected] UniversityofCalifornia atLosAngeles(UCLA) 10833LeConteAvenue LosAngeles,CA90095 USA [email protected] ISBN978-1-60761-450-0 e-ISBN978-1-60761-451-7 DOI10.1007/978-1-60761-451-7 SpringerNewYorkDordrechtHeidelbergLondon LibraryofCongressControlNumber:2009939537 ©SpringerScience+BusinessMedia,LLC2010 Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewritten permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY10013,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Usein connectionwithanyformofinformationstorageandretrieval,electronicadaptation,computersoftware, orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden. Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilarterms,eveniftheyare notidentifiedassuch,isnottobetakenasanexpressionofopinionastowhetherornottheyaresubject toproprietaryrights. Whiletheadviceandinformationinthisbookarebelievedtobetrueandaccurateatthedateofgoing topress,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityforany errorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,withrespect tothematerialcontainedherein. Coverillustration:ThelogoofAllergoOncologycreatedbyDr.ErikaJensen-JarolimandMr.Walter Jarolimtopromotethefirst“1stInternationalAllergoOncologySymposium,”whichtookplaceinVienna, Austria,onApril16,2007. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 ErikaJensen-JarolimandManuelL.Penichet 2 TheBiologyofIgE:MolecularMechanismRestraining PotentiallyDangerousHighSerumIgETitresInVivo . . . . . . . 13 GernotAchatz,GertrudeAchatz-Straussberger, StefanFeichtner,SebastianKoenigsberger, StefanLenz,DorisPeckl-Schmid,NadjaZaborsky, andMarinusLamers 3 TheBiologyofIgE:TheGenerationofHigh-AffinityIgE Antibodies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 MariaA.CurottodeLafailleandJuanJ.Lafaille 4 EpidemiologicalEvidence:IgE,Atopy,andSolidTumors . . . . . 47 MichelleC.Turner 5 Epidemiological Evidence: IgE, Allergies, and HematopoieticMalignancies . . . . . . . . . . . . . . . . . . . . . 79 OtonielMartínez-Maza,AlanDuaneMoreno,and WendyCozen 6 MastCellsinAllergyandTumorDisease . . . . . . . . . . . . . . 137 AnnaWasiuk,VictorC.deVries,ElizabethC.Nowak, andRandolphJ.Noelle 7 TheIgEAntibodyandItsUseinCancerImmunotherapy . . . . . 159 TracyR.Daniels,JoséA.Rodríguez,Elizabeth Ortiz-Sánchez,GustavoHelguera,andManuelL.Penichet 8 IgEInteractswithPotentEffectorCellsAgainstTumors: ADCCandADCP . . . . . . . . . . . . . . . . . . . . . . . . . . . 185 SophiaN.Karagiannis,FrankO.Nestle,andHannahJ.Gould 9 IgEasAdjuvantinTumorVaccination . . . . . . . . . . . . . . . 215 ElisaA.Nigro,AntonioG.Siccardi,andLucaVangelista v vi Contents 10 TheTargetsofIgE:Allergen-Associatedand Tumor-AssociatedMolecularPatterns. . . . . . . . . . . . . . . . 231 ErikaJensen-Jarolim,DianaMechtcheriakova,andIsabella Pali-Schoell 11 The Role of Th2-Mediated Anti-Tumor Immunity inTumorSurveillanceandClearance . . . . . . . . . . . . . . . . 255 LjubovSimson,JuliaI.Ellyard,andChristopherR.Parish SubjectIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 Contributors GernotAchatz DepartmentofMolecularBiology,UniversityofSalzburg, Salzburg,Austria GertrudeAchatz-Straussberger DepartmentofMolecularBiology,University ofSalzburg,Salzburg,Austria WendyCozen DepartmentsofPreventiveMedicineandPathology,KeckSchool ofMedicine,UniversityofSouthernCalifornia,LosAngeles,CA,USA MariaA.CurottodeLafaille MolecularPathogenesisProgram,TheKimmel CenterforBiologyandMedicineoftheSkirballInstituteandDepartmentof Pathology,NewYorkUniversitySchoolofMedicine,NewYork,NY,USA TracyR.Daniels DivisionofSurgicalOncology,DepartmentofSurgery, UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA VictorC.deVries DepartmentofMicrobiologyandImmunology,Dartmouth MedicalSchool,Lebanon,NH,USA JuliaI.Ellyard DivisionofImmunologyandGenetics,JohnCurtinSchoolof MedicalResearch,AustralianNationalUniversity,Canberra,ACT,Australia StefanFeichtner DepartmentofMolecularBiology,UniversityofSalzburg, Salzburg,Austria HannahJ.Gould RandallDivisionofCellandMolecularBiophysics,King’s CollegeLondon,Guy’sCampus,London,UK GustavoHelguera DivisionofSurgicalOncology,DepartmentofSurgery, UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA ErikaJensen-Jarolim IPP–DepartmentofPathophysiology,Centerof Pathophysiology,InfectiologyandImmunology,MedicalUniversityofVienna, Vienna,Austria SophiaN.Karagiannis NIHRBiomedicalResearchCentreatGuy’sandSt. Thomas’sHospitalsandKing’sCollegeLondon,CutaneousMedicineand Immunotherapy,St.John’sInstituteofDermatology,DivisionofGeneticsand vii viii Contributors MolecularMedicine,King’sCollegeLondonSchoolofMedicine,Guy’sHospital, London,UK SebastianKoenigsberger DepartmentofMolecularBiology,Universityof Salzburg,Salzburg,Austria JuanJ.Lafaille MolecularPathogenesisProgram,TheKimmelCenterfor BiologyandMedicineoftheSkirballInstituteandDepartmentofPathology,New YorkUniversitySchoolofMedicine,NewYork,NY,USA MarinusLamers MaxPlanckInstituteforImmunobiology,Freiburg,Germany StefanLenz DepartmentofMolecularBiology,UniversityofSalzburg,Salzburg, Austria OtonielMartínez-Maza DepartmentsofObstetricsandGynecologyand DepartmentofMicrobiology,Immunology,andMolecularGenetics,Jonsson ComprehensiveCancerCenter,AIDSInstitute,DavidGeffenSchoolofMedicine, UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA DianaMechtcheriakova IPP–DepartmentofPathophysiology,Centerof Pathophysiology,InfectiologyandImmunology,MedicalUniversityofVienna, Vienna,Austria AlanDuaneMoreno DepartmentofPreventiveMedicine,KeckSchoolof Medicine,UniversityofSouthernCalifornia,LosAngeles,CA,USA FrankO.Nestle NIHRBiomedicalResearchCentreatGuy’sandSt.Thomas’s HospitalsandKing’sCollegeLondon,CutaneousMedicineandImmunotherapy, St.John’sInstituteofDermatology,DivisionofGeneticsandMolecularMedicine, King’sCollegeLondonSchoolofMedicine,Guy’sHospital,London,UK ElisaA.Nigro DepartmentofBiologyandGenetics,UniversityofMilanandSan RaffaeleScientificInstitute,Milan,Italy RandolphJ.Noelle DepartmentofMicrobiologyandImmunology,Dartmouth MedicalSchool,Lebanon,NH,USA ElizabethC.Nowak DepartmentofMicrobiologyandImmunology,Dartmouth MedicalSchool,Lebanon,NH,USA ElizabethOrtiz-Sánchez DivisionofSurgicalOncology,DepartmentofSurgery, UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA IsabellaPali-Schoell IPP–DepartmentofPathophysiology,Centerof Pathophysiology,InfectiologyandImmunology,MedicalUniversityofVienna, Vienna,Austria ChristopherR.Parish DivisionofImmunologyandGenetics,JohnCurtin SchoolofMedicalResearch,AustralianNationalUniversity,Canberra,ACT, Australia Contributors ix DorisPeckl-Schmid DepartmentofMolecularBiology,UniversityofSalzburg, Salzburg,Austria ManuelL.Penichet DivisionofSurgicalOncology,DepartmentofSurgeryand DepartmentofMicrobiology,Immunology,andMolecularGenetics,Molecular BiologyInstitute,JonssonComprehensiveCancerCenter,DavidGeffenSchoolof Medicine,UniversityofCalifornia,LosAngeles(UCLA),LosAngeles,CA,USA JoséA.Rodríguez DivisionofSurgicalOncology,DepartmentofSurgeryand MolecularBiologyInstitute,UniversityofCalifornia,LosAngeles(UCLA),Los Angeles,CA,USA AntonioG.Siccardi DepartmentofBiologyandGenetics,UniversityofMilan andSanRaffaeleScientificInstitute,Milan,Italy LjubovSimson CentreforBiomedical,MolecularandChemicalResearch, UniversityofCanberra,ACT,Australia MichelleC.Turner McLaughlinCentreforPopulationHealthRiskAssessment, InstituteofPopulationHealth,FacultyofGraduateandPost-GraduateStudies, UniversityofOttawa,Ottawa,ONT,Canada LucaVangelista DepartmentofBiologyandGenetics,UniversityofMilanand SanRaffaeleScientificInstitute,Milan,Italy AnnaWasiuk DepartmentofMicrobiologyandImmunology,DartmouthMedical School,Lebanon,NH,USA NadjaZaborsky DepartmentofMolecularBiology,UniversityofSalzburg, Salzburg,Austria Chapter 1 Introduction ErikaJensen-JarolimandManuelL.Penichet 1.1 Background Infectious diseases, being the major burden in the history of mankind worldwide untilthebeginningofthe20thcentury,wereimportanttriggersintheunderstanding of immunological mechanisms. In contrast to infectious diseases, reports of aller- gies and cancers were less common, but increased tremendously within the last century.BasedontheUSmortalitydataoftheNationalCenterforHealthStatistics, CentersforDiseaseControlandPrevention2009,arecentreportfromtheAmerican CancerSocietyindicatedthatthenumberofcancerdeathsincreasedapproximately from100,000to550,000peryearbetween1930and2006,parallelingtheincrease of the total population during this period. Leading causes of death from cancer are lung and bronchus cancer, in men prostate cancer, and in women breast can- cer [1, 2]. Normalization to population size shows that the cancer death rate for mostmalignancieshasbeengenerallystable,althoughthemortalityrateofcertain malignancies,suchaslungandbronchuscancer,hasincreasedoverthelast50years [1-3]. Inallergy,thesituationislessclear,becauseforthetimeperiodaroundtheturnof the19thcentury,onlyimpreciseinformationisavailable.However,withinthelast30 yearstheincidencesofallergieshasdoublednotonlyinindustrialcountries,butin developingcountriesaswell[4].Fromthediagnosedatopicstateitisconcludedthat insomeareas,suchasinNewZealand,theincidenceofskinandrespiratoryaller- gies increased as much as40% inthepopulation [5].Thus,thecancer andallergy incidenceparalleleachother,whereasinfectiousdiseaseshavedecreasedinindustri- alizedcountries.Fromanepidemiologicalpointofview,thedecreasedparasiteand bacterialburden mayindirectlycorrelatewiththeincreasingcurves ofallergyand cancer,beingthusinaccordancewiththeso-calledhygienehypothesis.Thistheory linkstherecentlowerparasiteandmicrobeburdentoaberrantimmuneresponsesor failureofimmunemechanisms[6,7].However,ifallergiesandmalignanciesboth B E.Jensen-Jarolim( ) IPP-DepartmentofPathophysiology,CenterofPathophysiology,InfectiologyandImmunology, MedicalUniversityofVienna,Vienna,Austria e-mail:[email protected] M.L.Penichet,E.Jensen-Jarolim(eds.),CancerandIgE, 1 DOI10.1007/978-1-60761-451-7_1,(cid:2)C SpringerScience+BusinessMedia,LLC2010
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