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Subject Index—Volume 67 January |, pp. 1-214 No. 6, March 15, Supplement, pp. 1715-1824 January 1, Supplement, pp. 215-330 No. 7, April 1, pp. 1825-2020 January 15, pp. 331-546 No. 8, April 15, pp. 2021-2224 February 1, pp. 547-764 No. 9 May |, pp. 2225-2418 February 1, Supplement, pp. 765-868 No. 10, May 15, pp. 2419-2680 February 15, pp. 869-1118 No. 10, May 15, Supplement, pp. 2681-2730 February 15, Supplement, pp. 1119-1284 No. 11, June 1, pp. 2731-2948 March 1, pp. 1285-1470 No. 12, June 15, pp. 2949-3200 March 15, pp. 1471-1714 A Adrenal carcinoma 5-fluorouracil, doxorubicin, and cisplatin for, 2997 ABH(O) antigens simulating cutaneous angiosarcoma, 2766 in bladder intraepithelial dysplasia and transitional cell car- staging of, 1199 cinoma, 1661 Adrenoceptor density, in hepatocellular carcinoma, 2543 in esophageal carcinoma, 3042 Adrenocorticotropic hormone. See Ectopic adrenocorticotropic ABO(H) antigens, in transitional cell carcinoma of bladder, 3024 hormone syndrome Abortion, early, breast cancer proliferation and DNA ploidy Adriamycin. See Doxorubicin and, 1285 Adult T-cell leukemia, Ki-67-positive cells in, prognosis and, Acinic cell carcinoma, prognostic factors in, 172 2605 Aclacinomycin, in acute leukemia, with etoposide, 281, 285 Adult T-cell leukemia-lymphoma, with Hodgkin’s disease-like Acoustic neurinoma, radiosurgery of, 345 histologic features, 1622 Acquired immunodeficiency syndrome AE1 and AE3 monoclonal antibodies, in pleural mesothelioma disseminated leiomyosarcoma in, in child, 2618 differentiation, 655 primary central nervous system lymphoma in, 2756 African-Americans, metastatic breast cancer outcome in, vs. in ACTH. See Ectopic adrenocorticotropic hormone syndrome whites, 2850 Actinomycin D, single vs. fractionated, in Wilms’ tumor, 2990 Age. See also Children; Elderly Acute leukemia. See Leukemia, acute and breast cancer survival, 2227 Acute respiratory failure, in leukemia, 696 and hepatocellular carcinoma growth mode, 2626 Adenine nucleotide pools, in human peripheral leukocytes, hy- and prostate cancer treatment, 2633 perthermic effects on, 2096 AHBuBP bisphosphonate, osteolysis inhibition by, 643 Adenocarcinoma. See also sites of AIDS. See Acquired immunodeficiency syndrome bronchioloalveolar, with myoepithelial cells, 2356 Airway obstruction, life-threatening, Hodgkin’s disease pre- clear cell, of vagina and cervix, 1971 senting as, 506 of endometrium Alcohol with clear cell carcinoma, cell lines from, 1588 pancreatic cancer and, 2664 isolated calcaneal metastasis in, 1979 tongue cancer and, in Uruguay, 180 in Norway, 3093 Aldolase isozymes, in lung cancer, 2153 gastric, carcinoembryonic antigen in, radiation effects on, 2269 Alfred P. Sloan, Jr., Prize, 2422 hepatoid, of renal pelvis, 3051 Alpha-1 and beta-2 adrenoceptor density, in hepatocellular car- of lung cinoma, 2543 metastases in, cytofluometric analysis of, 2941 Alpha class glutathione S-transferase, immunohistologic local- pleural mesothelioma from, monoclonal antibody differ- ization of, 1608 entiation of, 655 Alpha-fetoprotein of pancreas, N-(phosphonacetyl)-L-aspartate and 5- fluoro- glucosaminylation and fucosylation of, in liver neoplasia dif- uracil for, 363 ferential diagnosis, 2390 of prostatic duct, 2118 from hepatoid adenocarcinoma of renal pelvis, 3051 serous papillary, of tunica vaginalis, 1450 lectin binding by, in hepatocellular carcinoma, 476 Adenoid cystic carcinoma, of esophagus, 2159 Alpha glutathione S-transferase, immunohistologic localization Adenoma, depressed gastric, 2382 of, 1608 Adenosquamous carcinoma, of lung, clinicopathologic charac- teristics of, 649 Alternative therapies, 1788, 2225 Adipose tissue distribution, breast cancer and, 523, 2215, 2622 Alveolar soft part sarcoma, vs. paraganglioma, 1894 Adolescents. See also Children American Cancer Society dietary guidelines, 2671 differentiated thyroid cancer in, 2186 American Cancer Society-National Prostate Cancer Detection synovial sarcoma in, 1667 Project, detection of early stage disease and, 2949 Subject Index—Volume 67 January |, pp. 1-214 No. 6, March 15, Supplement, pp. 1715-1824 January 1, Supplement, pp. 215-330 No. 7, April 1, pp. 1825-2020 January 15, pp. 331-546 No. 8, April 15, pp. 2021-2224 February 1, pp. 547-764 No. 9 May |, pp. 2225-2418 February 1, Supplement, pp. 765-868 No. 10, May 15, pp. 2419-2680 February 15, pp. 869-1118 No. 10, May 15, Supplement, pp. 2681-2730 February 15, Supplement, pp. 1119-1284 No. 11, June 1, pp. 2731-2948 March 1, pp. 1285-1470 No. 12, June 15, pp. 2949-3200 March 15, pp. 1471-1714 A Adrenal carcinoma 5-fluorouracil, doxorubicin, and cisplatin for, 2997 ABH(O) antigens simulating cutaneous angiosarcoma, 2766 in bladder intraepithelial dysplasia and transitional cell car- staging of, 1199 cinoma, 1661 Adrenoceptor density, in hepatocellular carcinoma, 2543 in esophageal carcinoma, 3042 Adrenocorticotropic hormone. See Ectopic adrenocorticotropic ABO(H) antigens, in transitional cell carcinoma of bladder, 3024 hormone syndrome Abortion, early, breast cancer proliferation and DNA ploidy Adriamycin. See Doxorubicin and, 1285 Adult T-cell leukemia, Ki-67-positive cells in, prognosis and, Acinic cell carcinoma, prognostic factors in, 172 2605 Aclacinomycin, in acute leukemia, with etoposide, 281, 285 Adult T-cell leukemia-lymphoma, with Hodgkin’s disease-like Acoustic neurinoma, radiosurgery of, 345 histologic features, 1622 Acquired immunodeficiency syndrome AE1 and AE3 monoclonal antibodies, in pleural mesothelioma disseminated leiomyosarcoma in, in child, 2618 differentiation, 655 primary central nervous system lymphoma in, 2756 African-Americans, metastatic breast cancer outcome in, vs. in ACTH. See Ectopic adrenocorticotropic hormone syndrome whites, 2850 Actinomycin D, single vs. fractionated, in Wilms’ tumor, 2990 Age. See also Children; Elderly Acute leukemia. See Leukemia, acute and breast cancer survival, 2227 Acute respiratory failure, in leukemia, 696 and hepatocellular carcinoma growth mode, 2626 Adenine nucleotide pools, in human peripheral leukocytes, hy- and prostate cancer treatment, 2633 perthermic effects on, 2096 AHBuBP bisphosphonate, osteolysis inhibition by, 643 Adenocarcinoma. See also sites of AIDS. See Acquired immunodeficiency syndrome bronchioloalveolar, with myoepithelial cells, 2356 Airway obstruction, life-threatening, Hodgkin’s disease pre- clear cell, of vagina and cervix, 1971 senting as, 506 of endometrium Alcohol with clear cell carcinoma, cell lines from, 1588 pancreatic cancer and, 2664 isolated calcaneal metastasis in, 1979 tongue cancer and, in Uruguay, 180 in Norway, 3093 Aldolase isozymes, in lung cancer, 2153 gastric, carcinoembryonic antigen in, radiation effects on, 2269 Alfred P. Sloan, Jr., Prize, 2422 hepatoid, of renal pelvis, 3051 Alpha-1 and beta-2 adrenoceptor density, in hepatocellular car- of lung cinoma, 2543 metastases in, cytofluometric analysis of, 2941 Alpha class glutathione S-transferase, immunohistologic local- pleural mesothelioma from, monoclonal antibody differ- ization of, 1608 entiation of, 655 Alpha-fetoprotein of pancreas, N-(phosphonacetyl)-L-aspartate and 5- fluoro- glucosaminylation and fucosylation of, in liver neoplasia dif- uracil for, 363 ferential diagnosis, 2390 of prostatic duct, 2118 from hepatoid adenocarcinoma of renal pelvis, 3051 serous papillary, of tunica vaginalis, 1450 lectin binding by, in hepatocellular carcinoma, 476 Adenoid cystic carcinoma, of esophagus, 2159 Alpha glutathione S-transferase, immunohistologic localization Adenoma, depressed gastric, 2382 of, 1608 Adenosquamous carcinoma, of lung, clinicopathologic charac- teristics of, 649 Alternative therapies, 1788, 2225 Adipose tissue distribution, breast cancer and, 523, 2215, 2622 Alveolar soft part sarcoma, vs. paraganglioma, 1894 Adolescents. See also Children American Cancer Society dietary guidelines, 2671 differentiated thyroid cancer in, 2186 American Cancer Society-National Prostate Cancer Detection synovial sarcoma in, 1667 Project, detection of early stage disease and, 2949 No. 12 SUBJECT INDEX—VOLUME 67 American Indians, acute lymphocytic leukemia survival in, 2125 radiotherapy and, 412 American Joint Committee Stage staging system, for nasopha- in untreated prostate cancer, 2200 ryngeal carcinoma, 434 sialyl Lewis A, in digestive cancer, 1576 Amsacrine tumor-associated, in lymph nodes, immune responses to, in in acute leukemia, with etoposide, 285 colon cancer, 2880 in acute lymphoblastic leukemia, 2235 Anti-keratin monoclonal antibody, in pleural mesothelioma dif- Anal canal, squamous cell carcinoma of, 2038 ferentiation, 655 Anal carcinoma, chemotherapy and radiotherapy for, 2462 Anti-Leu-M1 mononoclonal antibody, in pleural mesothelioma Analgesia, patient-controlled, 873 differentiation, 655 Anaplastic giant cell thyroid carcinoma, treatment of, 564 Anti-vimetin monoclonal antibody, in pleural mesothelioma Androgen receptors differentiation, 655 5 in colon cancer, 1964 Aortic arch occlusion, by Aspergillus, after antileukemic che- in laryngeal tumors, 1347 motherapy, 3123 in metastatic prostate cancer, 3057 Ara-C. See Cytosine arabinoside Anemia Argyrophil small cell carcinoma of cervix, cell line from inte- at Hodgkin’s disease diagnosis, prognosis and, 1389 grating HPV16 DNA, 2327 recombinant human erythropoietin in, 2708 Arterial embolization, transcatheter, in hepatocellular carci- Angiography, digital subtraction, in parapharyngeal heman- noma, 81, 385 giopericytoma, 61 Arterial portography, computed tomography during, in liver Angioimmunoblastic lymphoma, clinicopathology of, 2565 cancer, 1189 Angiosarcoma, cutaneous, adrenal carcinoma simulating, 2766 Asbestos, type and pulmonary concentration of, mesothelioma Angiosarcomatosis, intra-abdominal, after pelvic radiotherapy, risk and, 1912 2275 Asian Americans, increasing numbers of, cancer care and, 1773 Angiotropic lymphoma, congenital, 2131 Aspergillus, aortic arch occlusion by, after antileukemic che- Anthracyclines, in childhood cancer, osteosarcoma after, 193 motherapy, 3123 Antibodies Aspiration, ultrasound-guided, of ovarian tumors, 1326 in estrogen receptor localization, in gastric cancer, 2401 Aspiration biopsy HBA-71, in Ewing’s sarcoma and peripheral primitive neu- of bone tumors, 1169 roectodermal tumors, 1886 of breast cancer, for oncogene analaysis, 1396 against interferon-beta but not interferon-gamma, in mela- of cold thyroid nodules, 2137 noma, 2300 of hepatocellular carcinoma, 673 MIC2, in Ewing’s sarcoma and peripheral primitive nevroec- of lymph nodes, vs. excisional biopsy, 1003 todermal tumors, 1886 of lymphoproliferative lesions, in HIV-positive patients, 1008 monoclonal, in estrogen receptor localization, in gastric cancer, of occult breast lesions, with scouting needle, 2150 2401 in pancreatic duct stenosis, 2395 neutralizing, to interleukin-2, 1862 ultrasound guided, in esophageal cancer, 585 in pleural mesothelioma differentiation, 655 Astrocytic tumors, adult cerebral, bromodeoxyuridine- labeling RNL-1, 2, 3, to neuroendocrine antigens, 619 indices and prognosis in, 1629 Antibody fluorescein conjugates, for photodiagnosis of colon Astrocytoma cancer, 2529 cerebellar, histologic condition and treatment of, in children, Anti-CEA monoclonal antibody, in pleural mesothelioma dif- 2772 ferentiation, 655 high-grade, accelerated fractionation for, 2247 Antierythrocyte autoantibody formation, after interleukin-2 and intracarotid chemotherapy for, 2844 gamma-interferon, 2512 Autoimmune toxicity, of interleukin-2 and interferon- gamma, Antigen(s) 2512 blood group in bladder intraepithelial dysplasia, 1661 in esophageal carcinoma, 3042 B in transitional cell carcinoma of bladder, 3024, 1661 carcinoembryonic, in gastric adenocarcinoma cells, radiation Bacillus Calmette-Guerin therapy, in transitional cell carcinoma effects on, 2269 of bladder, ABO(H) antigens and beta-2 microgiobulin CD34, in Philadelphia chromosome-positive acute lympho- and, 3024 blastic leukemia, 1565 Bacteremia H, in squamous cell carcinoma, 613 clostridial, 1928 human leukocyte, in thyroid tumors, 977 staphylococcal, interleukin-2 therapy and, 1570 Ki-67, in breast tumors Barium enema, guidelines for, 1150 phenotypic differentiation and, 463 Basement membrane deposition, in squamous cell carcinoma prognosis and, 421 of lung, prognosis and, 3001 Lewis X, as Reed-Sternberg cell marker, 1338 B-cell lymphoma myeloid, in acute lymphoid leukemia, 3081 extragonadal monocytoid, 2305 neuroendocrine, 619 primary anterior mediastinal, 2579 proliferative-associated p105, in gastric carcinoma, 2523 primary cutaneous, 2311 prostate-specific BCG therapy, in transitional cell carcinoma of bladder, ABO(H) prognosis and, 3014 antigens and beta-2 microglobulin and, 3024 3168 CANCER June 15 1991 Vol. 67 Behavioral changes B.72.3 mononoclonal antibody, in pleural mesothelioma differ- assessment of, 805 entiation, 655 for cancer prevention Body fat distribution, breast cancer and, 523, 2215, 2622 assessment of, 805 Bone epidemiologic perspectives on, 808 leiomyosarcoma of, 1051 Behavioral research resorption of, bisphosphonate AHBuBP inhibition of, 643 current status of and future priorities for, 767, 865 sarcoma of. See Osteosarcoma for prevention and early detection, 800 tumors of, imaging of, 1169 Bence Jones multiple myeloma, meningeal involvement in, 1900 Ene marrow, breast cancer cells in, detection of, 1033 Benign neoplasm, intratumoral cytogenetic heterogeneity in, Boue marrow relapse, in acute lymphoid leukemia, 37 3110 Bone marrow transplantation Benzylguanidine, in neuroblastoma, 922 in chronic myelogenous leukemia, reappearance of Ph- neg- Beta-2 and alpha-1 adrenoceptor density, in hepatocellular car- ative cells after, 2959 cinoma, 2543 etoposide and, 292 Beta-carotene, cellular immunity and, 1556 late renal dysfunction in, 2795 Beta-human chorionic gonadotropin-positive extragonadal germ Bone scan, in early breast cancer follow-up, 55 cell neoplasia, of renal pelvis, 3146 Brachytherapy. See also Radiotherapy Biopsy in desmoid tumor, with surgery, 380 of bone tumors, 1169 gynecologic, perioperative morbidity and mortality with, 2786 excisional, of lymph nodes, vs. aspiration biopsy, 1003 Brain. See also under Central nervous system fiberoptic, in nasopharyngeal cancer diagnosis, 3127 Hodgkin’s disease of, and HIV infection, 2931 fine-needle aspiration metastases to, as first symptom in bronchogenic carcinoma, in breast cancer, for oncogene analysis, 1396 2935 of cold thyroid noduies, 2137 non-Hodgkin’s lymphoma of vs. excisional, of lymph nodes, 1003 in AIDS, 2756 of hepatocellular carcinoma, 673 Epstein-Barr virus in. in situ hybridization of, 2756 of lymph nodes, vs. excisional biopsy, 1003 after Hodgkin’s disease, 441 of lymphoproliferative lesions, in HIV-positive patients, as second malignancy, 1431 i008 tumors of of occult breast lesions, with scouting needle, 2150 accelerated fractionation radiotherapy for, 2247 in pancreatic duct stenosis, 2395 adult astrocytic, bromodeoxyuridine-labeling indices and ultrasound-guided prognosis in, 1629 in esophageal carcinoma, 585 imaging of, 1278 of ovarian tumors, 1326 in children, 1223 of liver tumors, 1189 intracarotid etoposide and cisplatin for, 2844 of lung tumors, fiberoptic bronchoscopy for, 72 Brain stem glioma, carboplatin for, 43 Blacks, metastatic breast cancer outcome in, vs. in whites, 2850 Breast, mammography for Black tobacco, bladder cancer and, in Uruguay, 536 in early breast cancer follow-up, 55 Bladder patient selection for, 2010 adenocarcinoma of, clinicopathology of, 2165 routine, in detection of asynchronous contralateral breast carcinoma of cancer, 1844 epidemiology of, in U.S. vs. Japan, 746 treatment reults after detection by, 2801 human leukocyte antigen II, interleukin-6, and interleukin- Breast cancer 6 receptor expression in, 2087 adjuvant therapy for, weight gain with, 1954 prognostic factors in, 1525 advanced, stanozolol for, 2966 risk factors for, in Uruguay, 536 asynchronous contralateral, early detection of, by routine intraepithelial dysplasia of, ABH(O) blood group antigens in, mammography, i844 1661 body fat distribution and, 523, 2215, 2622 transitional cell carcinoma of bone marrow micrometastasis in, detection of, 1033 ABH(O) antigens in, 1661 c-erbB2/neu expression in, 2142 ABO(H) antigens and beta-2 microglobulins in, 3024 chemotherapy for, physician nonadherence to, 945 Bleeding complications, in essential thrombocythemia, 2926 copper in, 738 Bleomycin ductal in situ in cervical cancer, with radical surgery, 372 conservative surgery and radiotherapy for, 7 fractionated cobalt 57-labeled, in vivo measurement of, 2477 with microinvasion, surgery only for, 1498 in head and neck cancer, with radiotherapy, 915 early, follow-up care in, 55 in lymphoma, in elderly, 1487 in eideiy, treatment and survivai in, 2227 Blood cells, control of growth and differentiation in, 2684 epidemiology of, in U.S. vs. Japan, 746 Blood count, in early breast cancer follow-up, 55 etoposide for, 266 Blood group antigens hormone receptors in, 463 in esophageal carcinoma, 3042 imaging of, for staging and follow-up, 1196 in oral squamous cell carcinoma, 613 intraductal, computerized image analysis of, 2805 in transitional cell carcinoma of bladder, 3024, 1661 Ki-67 immunostaining in, 463 Blue nevus, malignant, 2653 lumpectomy without radiation for, recurrence after, 2079 No. 12 SUBJECT INDEX—-VOLUME 67 mammographically detected, treatment results in, 2801 early detection of, behavioral research in, 800 mammographic densities and, 2833 epidemiology of, in U.S. vs. Japan, 746 mammography for in Framingham heart study cohort, | patient selection for, 2010 human costs of, 1716 screening, 1129 imaging of. See Imaging cost/benefit analysis for, 1245 immuosuppressive acidic protein in, 610 meningeal carcinomatosis in, 1685 in mothers of childhood sarcoma patients, 1467 metatastic, outcome of in blacks vs. whites, 2850 occult, deep vein throinbosis and, 541 in mothers of childhood sarcoma patients, 1467 poorly differentiated of unknown primary site, etoposide for, node-negative 310 adjuvant therapy for, prognostic factors in patient selection prepaid delivery system for, 1767 for, 1741 prevention of chemotherapy for, 1744 demographic factors in, 1814 nucleolar organizer region—associated proteins in, 463 inner city clinic for, 1802 oncogene amplification in, 1396 lifestyle modification and health promotion for peanut lectin binding in, 463 assessment of, 805 phosphate metabolites and hormone receptors in, 2919 epidemiologic perspectives on, 808 physical examination screening for, in Japan, 2021 psychosocial and behavioral research in, 767, 800, 813, 833, Pneumocystis carinii pneumonia in, 2407 860, 865 pregnancy-associated, prognosis in, 869 school health education for, 1828 progesterone receptors in psychoneuroimmunology and, 813 DNA synthesis arrest and, 1352 psychosocial and behavioral research in, 767 immunohistochemical evaluation of, 455 enabling strategies for, 860 proliferation and DNA ploidy in, early oral contraceptive use future priorities for, 865 and early abortions and, 1285 psychosocial research in, in children, 833 psychosocial adjustment in, 1097 screening for. See Screening risk of, mammographic densities and, 2833 social environment and social support in, 788, 794 screening for, in Japan, 2021 Cancer care serum melatonin depression in, 1681 access to, 1736 soluble histocompatibiltiy antigen class I in, tumor burden economic factors in, 1718, 1728, 1732, 1736, 17468, 1750, and, 2295 1814 tamoxifen with and without fluoxymesterone in, 886 advances in, costs of, 1718 thermography in, prognosis and, 1678 alternative therapies in, 1788, 2225 tumor heterogeneity in, flow cytometric determination of, cessation of, in advanced disease, 1817 1401 clinical trials for. See Clinical trials tumor markers in, 463 continuity of, 1759 zinc in, 738 cost containment measures for, 1718, 1728 Breast lesions, occult, scouting needle aspiration of, 2150 demographic changes and, 1728, 1772 Breast lymphoma, 1359 legislative influences on, 1732 Breast-ovarian cancer, familial, 1460 palliative, 1817 Breast tumors patient perceptions of, 1783 benign vs. malignant, phosphate metabolites and hormone psychosocial and behavioral research in, 767, 813, 833, 860, receptors in, 2919 865 Ki-67 immunostaining in, prognosis and, 421 quality assurance in, 1800 syringomatous squamous, 2350 quality of, measurement of, 1753 Bromodeoxyuridine-labeling indices, in adult cerebral astrocytic rationing of, 1718, 1728, 1814 tumors, prognosis and, 1629 Carboplatin Bronchial carcinoid, growth hormone-releasing hormone in, in brain stem glioma, 43 2538 in esophageal squamous cell carcinoma, 354 Bronchioloalveolar adenocarcinoma, with myoepithelial cells, in small cell lung cancer, 2980 2356 Carcinoembryonic antigen Bronchogenic carcinoma. See Lung, carcinoma of in early breast cancer follow-up, 55 Bronchoscopy, fiberoptic, for lung tumor biopsy, 72 in gastric adenocarcinoma cells, radiation effects on, 2269 Bronchus, cancerous and precancerous lesions of, nucleolar or- Carcinogenesis, foreign body (editorial), 2731 ganizer regions in, 472 Carcinoid tumors Brush biopsy, of lung tumors, fiberoptic bronchoscopy for, 72 bronchial, growth hormone-releasing hormone in, 2538 cyproheptadine for, 33 € gastric, precursor lesions of, 663 interferon for, 547 CA 125, in non-small cell lung cancer, 150 Cardiac rhabdomyosarcoma, magnetic resonance imaging of, Calcaneal metastasis, isolated, in endometrial adenocarcinoma, 2066 1979 Cardiomyopathy, doxorubicin, in Wilms’ tumor survivors, 331 Cancer beta-Carotene, cellular immunity and, 1556 advanced, cessation of treatment in, 1817 Catheter, Hickman, interpericardial 5-fluorouracil infusion via, data assessmeni for, 780 735 3170 CANCER June 15 1991 Cauda equina compression, from metastziic melanoma, pallia- in brain stem glioma, 43 tive radiotherapy for, 2472 in breast cancer, 260 CD34 antigen, in Philadelphia chromosome-positive acute with hormonal therapy, 886 lymphoblastic leukemia, 1565 with node-negative disease, 1741, 1744 Cellular immunity, 13-cis-retinoic acid and beta carotene and, physician nonadherence to, 945 1556 Pneumocystis carinii pneumonia and, 2407 Central nervous system lymphoma weight gain with, 1954 in AIDS, 2756 in canine ostzosarcoma, response to, percent tumor necrosis Epstein-Barr virus in, in situ hybridization for, 434 and, 126 after Hodgkin’s disease, 440 in carcinoid tumor and malignant carcinoid syndrome, 33 as second malignancy, 1431 in cervical cancer Central nervous system tumors interferon system and, 87 in children, imaging of, 1223 with radical surgery, 372 embryonal neuroepithelial, differentiation in, 965 in childhood cancer, osteosarcoma after, 193 c-erbB2/neu expression, in head and neck tumors and breast clinical trials of. See Clinical trials cancer, 2142 in colorectal carcinoma, 14, 1294 c-erbB-2 oncoprotein, in gastric carcinoma, prognosis and, 2914 in ectopic adrenocorticotropic hormone syndrome, 1447 Cerebellar astrocytoma, histologic condition and treatment of, in esophageal carcinoma, with radiotherapy, 2258 in children, 2772 in esophageal squamous cell carcinoma, 354 Cerebral astrocytoma, high-grade, accelerated fractionation for, in gastric carcinoma, 260, 2454 2247 in germ cell tumors, 20 Cerebral lymphoma. See Central nervous system lymphoma for salvage, 1305 Cerebral metastases in head and neck cancer, with radiotherapy, 915 as first symptom in bronchogenic carcinoma, 2935 in hepatocellular carcinoma, transcatheter arterial emboli- from ovarian carcinoma, 2194 zation and arterial infusion in, prognostic factors for, Cerebral tumors. See Brain, tumors of 385 Cervix in Hodgkin’s disease, 271 carcinoma of in idiopathic hypereosinophilic syndrome, 2826 argyrophil small cell, cell line from integrating HPV16 intracarotid, in brain tumors, 2844 DNA, 2327 intraperitoneal, in advanced ovarian cancer, with radiother- brachytherapy for, perioperative morbidity and mortality apy, 2867 with, 2786 intrathecal chemotherapy aad radical surgery for, 372 in acute lymphocytic leukemia, hemiparesis and ischemia imaging of, 1209 after, 2058 interferon system in, 87 acute tumor lysis syndrome after, 2062 prognostic factors in, 2776 in leukemia, 281, 285 radiotherapy for in lung cancer lymphoctye subset distribution after, 2071 non-small cell, 2969, 2974, 250, 254, 892, 2439 second cancer after, 398 vs. symptomatic treatment, 2443 recurrent, iodine-125 interstitial implants in, 2467 with radiotherapy, 357 screening for, cost/benefit analysis for, 1245 small cell, 2980 clear cell adenocarcinoma of, 1971 in lymphoma intraepithelial neoplasia of, acid-labile DNA measurement in, in elderly, 1487 3104 neuropathy and myopathy in, 2241 Langerhans cell histiocytosis of, 1650 in malignant pleural mesothelioma, 48 c-fms proto-oncogene, in gynecologic cancers, 990 in melanoma, 1514 Charles F. Kettering Prize, 2428 in Mevkel cell carcinoma, tumor lysis syndrome and, 2207 Charles S. Mott Prize, 2431, 2436 nausea and vomiting in Chemoembolization, transcatheter arterial, in hepatocellular data assessment for, 780 carcinoma, 81, 385 physitilogic and psychobehavioral research in, 813 Chemotherapy. See also specific agents in neuroblastoma, 922 in acute leukemia, aortic arch occlusion by Aspergillus ana, in non-Hodgkin’s lymphoma, 271 3123 in orbital rhabdomyosarcoma, 560 in acute leukemia/lymphoma, in children, 1830 in osteosarcoma, acute lymphoblastic leukemia with t(4;11) in acute lymphoblastic leukemia, “spread out” vs. “upfront,” translocation after, 2887 550 in Ovarian cancer, response to, cloning assay for, 20 in acute lymphoid leukemia, for first relapse, 37 in paranasal sinus and nasopharyngeal tumors, with radio- in acute myleloid leukemia, in elderly, 1484 therapy, 2748 in acute nonlymphoblastic leukemia, 2235 physician nonadherence to, predictors of, 945 in adrenal cortical carcinoma, 2997 in pregnancy, 703 in adult Wilms’ tumor, 956 with radiotherapy, rationale for, 1471 in anal cancer, with radiotherapy, 2462 in recurrent pelvic desmoid tumor, 1443 in anaplastic giant cell thyroid carcinoma, 564 in renal cell carcinoma, 1509 in bone tumors, 1169 resistance to, in kidney tumors, circumvention of, 2484 No. 12 SUBJECT INDEX—VOLUME 67 in small cell carcinoma of vulva, 2415 in germ cell tumor, with etoposide, 28 in small cell lung cancer, 231, 245 in hepatocellular carcinoma, 896 in squamous cell carcinoma of skin, 2030 intracarotid, in brain tumors, 2844 in stage IV neuroblastoma, in infants, long-term survival and, intraperitoneal, in advanced ovarian cancer, with radiother- 1493 apy, 2867 in unresectable rectal cancer, with radictherapy, 2859 in lung cancer, with radiotherapy, 357 in urothelial cancer, response to, 1525 in malignant meosthelioma, of pleura, 48 in Wilms’ tumor ir. malignant mesothelioma, with doxorubicin, 2984 late effects of, 331 in metastatic melanoma, with dacarbazine, 1514 for relapse, 567 nephrotoxicity of, probenecid for, 1518 Chest radiography in non-small cell lung cancer, 892, 2439 for lung cancer screening, 1155 with 5-fluorouracil, 2969 for lung cancer staging, 1165 with interferon alpha-2B, 2448 Children. See also specific cancers of childhood; e.g., Leukemia; with novobiocin, 2969 Neuroblastoma vs. symptomatic treatment, 2443 acquired immunodeficiency syndrome in, disseminated leio- with vinblastine, 2969 myosarcoma in, 2618 in paranasal sinus and nasopharyngeal tumors, with radio- adolescent therapy, 2748 differentiated thyroid cancer in, 2186 prolonged intra-arterial infusion of, increased tissue levels with, synovial sarcoma in, 1667 2828 cancer survivor in small cell lung cancer, vs. etoposide, 245 achievment of life goals by, 206 in squamous cell carcinoma of skin, 2030 cancer in relatives of, 1467 in urothelial cancer, response to, 1525 cholelithiasis in, 1439 Clear cell adenocarcinoma, of vagina and cervix, 1971 central nervous system tumors in, imaging of, 1223 Clear cell carcinoma cerebellar astrocytoma of, histologic condition and treatment of endometrium, with adenocarcinoma, cell lines from, 1588 of, 2772 of inguinal region, arising from endometriosis, 116 craniospinal irradiation in, for malignant intracranial epen- Clear cell sarcoma, of soft tissue, DNA content of, 2173 dymoma, 2766 Clinical trials differentiated thyroid cancer in, 2186 access to and reimbursement for, 1750, 1779 infant family physician’s perspective on, 1798 brain stem glioma in, carboplatin for, 43 nurses’ expanding role in, 1793 stage IV neuroblastoma in, long-term survival in, 1493 participation in, economic factors in, 1750 osteosarcoma as second malignancy in, 193 Cloning assay, for chemotherapy response, in ovarian cancer, psychosocial research in, 833 20 sarcoma survivor, cancer in relatives of, 1467 Clostridial bacteremia, in cancer patients, 1928 sun-induced freckles in, 1990 Colitis, ulcerative, extracolonic malignancies in, 2015 synovial sarcoma in, 1667 Collagen IV, in colorectal carcinoma, prognosis and, 99 very young, Hodgkin’s disease in, 1428 Colon carcinoma. See also Colorectal carcinoma young, osteosarcoma in, 638 DNA in multiple tumor samples of, 106 Cholelithiasis epidemiology of, in U.S. vs. Japan, 746 after childhood cancer, 1439 hormone receptors in, 1964 colorectal carcinoma and, 1696 imaging of, 1150 Chondrosarcoma immune responses to tumor-associated antigens in lymph magnetic resonance imaging and phosphorus spectroscopy of, nodes in, 2880 1849 node-positive, prognosis of, 1859 of synovium, 155 photoimmunodiagnosis of, antibody-fluorescein conjugates Chronic leukemia. See Leukemia, chronic for, 2529 Chronic nonleukemic myeloproliferative disorders, life expec- protein tyrosine kinase levels in, 590 tancy in, 2658 ultrasound-guided hepatic cryosurgery in, 901 Cigarette smoking Colonoscopy, 1150 bladder cancer and, in Uruguay, 536 Colorectal carcinoma pancreatic cancer and, 2664 collagen IV in, prognosis and, 99 tongue cancer and, in Uruguay, 1380 DNA ploidy and cellular atypia in, 1642 Cirrhosis, hepatocullular carcinoma in, thrombin- antithrombin DNA ploidy in, prognosis and, 1921 2776 complexes in, 481 5-fluorouracil and cisplatin for, 14 Cisplatin 5-fluorouracil for, 367 in adrenal cortical carcinoma, 2997 with cisplatin, 14, 1294 in anaplastic giant cell thyroid carcinoma, 564 gallstones and, 1696 in canine osteosarcoma, response to, percent tumor necrosis imaging of, 1181 and, 126 intraoperative electron beam radiotherapy for, 1504 in cervical cancer, with radical surgery, 372 natural history of, 1143 in colorectal carcinoma, 1294 recurrence of, DNA content and, 2599 with 5-fluorouracil, 14 Complete blood count, in early breast cancer follow- up, 55 3172 CANCER June 15 1991 Computed tomography. See also Imaging Daunorubicin of adult primary gliomas, 1278 in acute leukemia, with etoposide, 285 advances in, 1121 in childhood cancer, osteosarcoma after, 193 of bone tumors, 1169 Deep venous thrombosis, occult cancer in, 541 of central nervous system tumors, in children, 1223 Demographic changes, health care issues and, 1728, 1772 cost/benefit analysis for, 1245 Depressed gastric adenoma, 2382 of gastrointestinal cancer, for staging and follow-up, 1181 Dermatcfibrosarcoma, magnetic resonance imaging and phos- of gynecologic cancer, 1209 phorus spectroscopy of, 1849 of Hodgkin’s and non-Hodgkin’s lymphoma, 1177 Dermoid cyst, of ovary, melanoma in, 3141 of liver cancer, 1189 Desmoid tumor of metastatic tumors of unknown origin, 1242 brachytherapy and surgery for, 380 ; of parapharyngeal hemangiopericytoma, 61 magnetic resonance imaging and phosphorus spectroscopy of, single photon emission, 1261, 1271 1849 Computerized image analysis recurrent pelvic, tamoxifen for, 1443 of intraductal breast cancer, 2805 Diagnosis, early, behavior research in, 800 of ovarian cancer, prognostic value of, 1318 Diagnostic imaging. See Imaging Congenital angiotropic lymphoma of T-cell type, 2131 Diamine oxidase, post-heparin, in small intestinal lymphoma, Congenital ocular melanoma, 2642 511 Copper, breast cancer and, 738 Diet, tongue cancer and, in Uruguay, 180 Corticosteroids, in lymphoma, neuropathy and myopathy in, Dietary modifications, recommendations for and implementa- 2241 tion of, 2671 Cost/benefit analysis Digestive cancer, sialyl Lewis A antigens in, 1576 for hematopoietic growth factors, 2727 Digital subtraction angiography, in parapharyngeal hemangio- for imaging studies, 1245 pericytoma, 61 Cranial nerve palsy, in childhood acute lymphoblastic leukemia DNA, HPV16, argyrophil small cell carcinoma of cervix and, and non-Hodgkin’s lymphoma, 2262 2327 Craniospinal irradiation, in malignant intracranial ependymoma, DNA alterations, somatic, in ovarian cancer, 1551 in children, 2766 DNA content Crohn’s disease, extracolonic malignancies in, 2015 acid-labile, in cervical intraepithelial neoplasia, 3104 Cryosurgery, hepatic, ultrasound-guided, in hepatocellular car- of breast cancer cinoma, 901 early oral contraceptive use and early abortions and, 1285 Cutaneous angiosarcoma, adrenal carcinoma simulating, 2766 for tumor heterogeneity determination, 1401 Cutaneous lymphoma of clear cell sarcoma of soft tissue, 2173 B-cell, 2311 of colon cancer, tumor sampling variability in, 106 13-cis-retinoic acid and, 2490 of colorectal cancer, 1642 Cyclocytidine, in acute lymphoblastic leukemia, 2235 prognosis and, 1921 Cyclophosphamide recurrence and, 2599 in acute lymphoid leukemia, for first relapse, 37 of esophageal carcinoma, recurrence time and, 1406 in lymphoma, in elderly, 1487 of esophageal squamous cell carcinoma, prognosis and, 2290 in malignant pleural mesothelioma, 48 of gastric carcinoma, prognosis and, 2588 Cyproheptadine, in carcinoid tumor and malignant carcinoid of hematogenous vs. lymphatic metastases, in lung adeno- syndrome, 33 carcinoma, 2941 Cyst, ovarian dermoid, melanoma in, 3141 of hepatocellular carcinoma, 939 Cystadenocarcinoma, mucinous pancreatic, with pseudosar- of !aryngeal squamous cell carcinoma, 141 comatous mural nodules, 494 of lymph nodes, in lung cancer, prognosis and, 1370 Cystoprostatectomy, transurethral-resection zone prostate cancer of malignant pleural effusions, after intracavitary methyl- detection by, 1418 prednisolone acetate, 3136 Cytogenetic heterogeneity, in benign neoplasm, 3110 of melanoma, metastasis and, 2333 Cytokines. See also Hematopoietic growth factors of metastatic soft tissue melanoma, 2173 biology of, transfusion medicine and, 2708 in multiple myeloma, 449 combination therapy with, 2718 of nonseminomatous germ cell tumors, 1874 Cytometry, DNA flow. See DNA content of ovarian carcinoma, prognosis and, 1878 Cytosine arabinoside of prostate cancer, prognosis and, 3014 in acute leukemia, with etoposide, 281, 285 DNA image cytometry, of esophageal squamous cell carcinoma, in acute lymphoblastic leukemia, “spread out” vs. “upfront,” 2290 550 DNA synthesis, in breast cancer, arrest of with progesterone in acute lymphoid leukemia, for first relapse, 37 receptor expression, 1352 DNA technology, in tumor gene identification (Charles S. Mott D Prize), 2436 Dacarbazine, in metastatic melanoma, with cisplatin, 1514 Double-contrast barium enema, guidelines for, 1150 Dactinomycin Down’s syndrome, acute lymphocytic leukemia in, 1057 in mesothelioma, with tumor necrosis factor, 2495 Doxorubicin single vs. fractionated, in Wilms’ tumor, 2990 in acute lymphoid leukemia, for first relapse, 27 Data assessment, for chemotherapy-induced nausea, 780 in adrenal cortical carcinoma, 2997 No. 12 SUBJECT INDEX—VOLUME 67 3173 in anaplastic giant cell thyroid carcinoma, 564 Epidermoid cancer, of head and neck, radical neck dissection in childhood cancer, osteosarcoma after, 193 in, 67 in gastric cancer, with 5-fluorouracil, 2454 Epipodophyllotoxins, in acute lymphoblastic leukemia, hyper- in lymphoma, in elderly, 1487 sensitivity to, 1070 in malignant mesothelioma Epitopes, tumor-associated antigen, in lymph nodes, in colon with cisplatin, 2984 cancer, 2880 of pleura, 48 Epstein-Barr virus, in central nervous system lymphoma, in situ resistance to, in renal carcinoma, trifluoperazine circumven- hybridization for, 434 tion of, 2484 Esophageal carcinoma in urothelial cancer, response to, 1525 adenoid cystic, 2159 in Wilms’ tumor, late effects of, 331 blood-group-related antigens in, 3042 Drainage, subxiphoid window, of pericardial effusion, vs. peri- epidemiology of, in U.S. vs. Japan, 746 cardiectomy, 76 glutathione S-transferase-pi mRNA in, 2560 Dysgerminoma, ovarian, radiotherapy for, long-term effects of, imaging of, for staging and follow-up, 1181 1084 radiotherapy with and without chemotherapy for, 2258 Dyspiastic nevus recurrence time in, DNA ploidy and, 1406 melanocytic, clinical and histopathologic features of, 3157 17-beta estradiol growth inhibition of, 2284 sunlight and, 1701 squamous cell carboplatin and vinblastine for, 354 E DNA image cytometry of, 2290 epidermal growth factor receptor in, 91 EAB902 mononoclonal antibody, in pleural mesothelioma dif- supraclavicular lymph node biopsy in, 585 ferentiation, 655 ultrasound staging in, 585 Economic factors Essential thrombocythemia in cancer care. See under Cancer care life expectancy in, 2658 in hematopoietic growth factor therapy, 2727 thrombotic and hemorrhagic complications in, 2926 Ectopic adrenocorticotropic hormone syndrome, ketoconazole 17 beta-Estradiol, esophageal cancer growth inhibition by, 2284 for, 1447 Estrogen receptors Education, school-based, for cancer prevention, 1828 in breast cancer, 463 Elderly in breast tumors, 2919 acute myeloid leukemia in, 13-cis-retinoic acid for, 1484 in colon cancer, 1964 breast cancer in, treatment and survival in, 2227 in gastric cancer, localization of, 2401 increasing number of, health care costs and, 1728, 1772 in laryngeal tumors, 1347 poor-prognosis lymphoma in, brief combination chemother- Estrone, breast cancer and, 2215 apy for, 1487 Etoposide Embolization, transcatheter arterial, in hepatocellular carcinoma, 381, 385 in acute leukemia, 281, 285 Embryonal neuroepithelial tumors, of central nervous system, hypersensitivity to, 1070 in adult Wilms’ tumor, 956 differentiation in, 965 Endometriosis, clear cell carcinoma of inguinal region arising bone marrow transplantation and, 292 in breast cancer, 266 from, 116 Endometrium clinical pharmacology of, 319 adenocarcinoma of current and future status of, 215 with clear cell carcinoma, cell lines from, 1588 future directions for, 315 isolated calcaneal metastasis in, 1979 in germ cell tumor, with cisplatin, 28 in Norway, 3093 in Hodgkin’s and non-Hodgkin’s lymphoma, 271 carcinoma of in idiopathic hypereosinophilic syndrome, 2826 brachytherapy for, perioperative morbidity and mortality intracarotid, in brain tumors, 2844 with, 2786 in lymphoma, in elderly, 1487 in non-small cell lung cancer, 250, 254 imaging of, 1209 with cisplatin, 2439 macrophage colony-stimulating factor and receptor in, 990 radiotherapy for, 2872 oral recurrent, iodine-125 interstitial implants in, 2467 chronic, 303, 315 tumor size in, prognosis and, 2791 vs. intravenous, pharmacology of, 299 Langerhans cell histiocytosis of, 1650 in ovarian cancer, 225 Endoscopic ultrasound, of gastrointestinal cancer, for staging in poorly differentiated carcinoma of unknown primary site, and foiiow-up, 1181 310 Ependymoma, malignant intracranial, craniospinal irradiation in small cell lung cancer, 231 for, in children, 2766 vs. cisplatin, 245 Ephelides, in children and young adults, 1990 in testicular cancer, 220 Epidemiology, cancer, in U.S. vs. Japan, 746 Ewing’s sarcoma Epidermal growth factor receptors histopathology of, prognosis and, 163 in laryngeal tumors, 1347 MIC2 antibodies in, 1886 in squamous cell carcinoma, 91 radiotherapy for, 2818 3174 CANCER June 15 1991 Excisional biopsy, vs. fine-needle aspiration biopsy, of lymph G nodes, 1003 Experimental therapy. See Clinical trials Gallstones Extracranial primitive neuroectodermal tumors, 1825 after childhood cancer, 1439 Extremity soft tissue sarcoma, reirradiation for, 2813 colorectal carcinoma and, 1696 Eye, congenital melanoma of, 2642 Ganglioside GM3:GD3 ratio, in melanoma, 3029 Gastric adenocarcinoma, carcinoembryonic antigen in, radiation effects on, 2269 F Gastric adenoma, depressed, 2382 Gastric carcinoid, precursor lesions of, 663 Familial cancers, recessive mutations and (Charles S. Mott Prize), Gastric carcinoma 2431 c-erbB-2 oncoprotein in, prognosis and, 2914 Familial natural killer cell-T-lymphocyte proliferation disease, DNA —— of, prognosis and, 2588 2610 epidemioiogy of, in U.S. vs. Japan, 746 Familial ovarian cancer, 1460 estrogen receptor localization in, 2401 Fat, body distribution of, breast cancer and, 523, 2215, 2622 etoposide for, 260 '8F_2-deoxy-2-fluoro-D-glucose, uptake of in tumor xenografts, 5-fluorouracil and doxorubicin for, 2454 1544 idarubicin for, 2988 Ferritin, serum, gastric cancer risk and, 1707 imaging of, 1181 Fetal cellular rhabdomyoma, of tongue, vs. rhabdomyosarcoma, proliferative-associated nuclear antigen p105 in, 2523 2907 serum ferritin and, 1707 alpha-Fetoprotein splenectomy in, survivai and, 3006 from hepatoid adenocarcinoma of renal pelvis, 3051 weight loss in, 722 lectin binding by, in hepatocellular carcinoma, 476 Gastrointestinal pseudomalignant lesions of, bizarre stromal cells in liver neoplasia differential diagnosis, 2390 in, 2111 Fiberoptic endoscopy, in nasopharyngeal cancer diagnosis, 3127 Gastrointestinal tumors, imaging of, 1181 Fibrin, vascular, in prostate cancer and hyperplasia, 1377 GD3:GM3 ratio, in melanoma, 3029 Fibroblastic/fibrohistiocytic proliferations, pyruvate kinase ac- Gender, and osteosarcoma incidence and survival, 2219 tivity and isozyme composition in, 2552 Gene mutations, recessive, in cancer etiology (Charles S. Mott Fine-needle aspiration biopsy Prize), 2431 of bone tumors, 1169 General Motors Cancer Research Foundation Prizes, 2422, 2428, in breast cancer, for oncogene analysis, 1396 2431, 2436 of cold thyroid nodules, 2137 Gene regulation (Alfred P. Sloan , Jr., Prize), 2422 of hepatocellular carcinoma, 673 Generic health outcomes, conceptualization and measurement of lymph noues, vs. excisional biopsy, 1003 of, 774 of lymphoproliferative lesions, in HIV-positive patients, 1008 Genes, tumor, identification of with DNA technology (Charles of occult breast lesions, with scouting needle, 2150 S. Mott Prize), 2436 in pancreatic duct stenosis, 2395 Gene transfer, into hematopoietic cells, 2700 ultrasound-guided, in esophageal carcinoma, 585 Genital tract, female. See also Gynecologic tumors Flow cytometry Langerhans cell histiocytosis of, 1650 DNA. See DNA content Genotyping, of equivocal hematolymphoid lesions, 2890 RNA, in multiple myeloma, 449 Fludarabine, in hairy cell leukemia, 1291 Germ cell tumor(s) beta-human chorionic gonadotropin-positive extragonadal, 5-Fluorouracil of renal pelvis, 3146 in adrenal cortical carcinoma, 2997 etoposide and cisplatin for, 28 in anal cancer, with radiotherapy, 2462 nonseminomatous in colorectal carcinoma, 367, 1294 DNA ploidy in, 1874 with and without cisplatin, 14 in gastric cancer, with doxorubicin, 2454 extragonadal and poor risk, prognostic factors in, 2049 salvage therapy for, 1305 intrapericardial infusion of, 735 tumor markers in, risk assignment and, 1299 in malignant pleural mesothelioma, 48 in non-small cell lung cancer, 2974, 892 Glioblastoma, adult, bromodeoxyuridine-labeling indices and with cisplatin, 2439 prognosis in, 1629 in pancreatic adenocarcinoma, with N-(phosphonacetyl)-L- Glioma aspartate, 363 adult primary, imaging of, 1278 in squamous cell carcinoma of skin, 2030 brain stern, carboplatin for, 43 in unresectable rectal cancer, with leucovorin and radiother- radiation-induced, 392 apy, 2859 Gliosarcoma, clinicopathology of, 2342 Fluoxymesterone, in breast cancer, with tamoxifen, 886 Glottic carcinoma, radiotherapy for, recurrence after, 577 Forceps biopsy, of lung tumors, fiberoptic bronchoscopy for, 72 Glutathione S-transferase-pi mRNA, in esophageal carcinoma, Foreign body carcinogenesis (editorial), 2731 2560 Framingham heart study cohort, cancer experience in, | Glutathione S-transferases, alpha, mu, and pi classes of, im- Freckles, sun-induced, in children and young adults, 1990 munohistologic localization of, 1608

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