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Canadian Journal of Revue canadienne Physiology and de physiologie et Pharmacology pharmacologie Contents Sommaire Volume 80, 2002 Volume 80, 2002 January / janvier ARTICLES / ARTICLES G.L. Wright, S. Wang, M.E. Fultz, I. Arif, K. Matthews, and B.S. Chertow Effect of vitamin A deficiency on cardiovascu- lar function in the rat Martin G. Latour and W. Wayne Lautt Insulin sensitivity regulated by feeding in the conscious unrestrained rat R. Menéndez, R. Mas, A.M. Amor, N. Ledon, J. Pérez, R.M. Gonzalez, I. Rodeiro, M. Zayas, and S. Jiménez Inhibition of rat lipoprotein lipid peroxidation by the oral administration of DOO3, a mixture of very long-chain saturated fatty acids Pryamvada Varma, Xianggian Qi, David Newman, and Paul Dorian Combination /,, and /,, channel blockade: no additive lowering of the defibrillation threshold Y. Chen, M. Chang, Z.Z. Wang, L.X. Chen, Q. Yang, Y.M. Qi, and R. Wang’ [Nphe Jnociceptin(1—13)-NH, antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat Vito Sanci, Sylvain Houle, and Jean N. DaSilva No change in dopamine D, receptor in vivo binding in rats after sub-chronic haloperidol treatment Carlos F. Santos, Carmem A. Paula, Maria Cristina O. Salgado, and Eduardo Brandt Oliveira Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease Charles Blais, Jr., Nathalie Lapointe, Jean-Lucien Rouleau, Robert Clément, Dimcho R. Bachvarov, and Albert Adam Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats: interaction with cardiac cytokine expression Rakesh Kakkar, Dallas P. Seitz, Rani Kanthan, Raju V.S. Rajala, Jasim M. Radhi, Xinto Wang, Mohammed K. Pasha, Rui Wang, and Rajendra K. Sharma Calmodulin-dependent cyclic nucleotide phosphodiesterase in an experimental rat model of cardiac ischemia—reperfusion M. Storr, E. Gaffal, D. Saur, V. Schusdziarra, and H.D. Allescher Effect of cannabinoids on neural transmission in rat gastric fundus Grant A. Millar, James A. Hardin, Leonard R. Johnson, and D. Grant Gall The role of PI 3-kinase in EGF-stimulated jejunal glucose transport Instructions to Authors Recommendations aux auteurs February / février BIOLOGY OF CELLULAR INVASIVENESS: PATHS OF CONVERGENCE AND DIVERGENCE IN PREGNANCY AND MALIGNANCY / LA BIOLOGIE DE L'INVASION CELLULAIRE : LES PARCOURS CONVERGENTS ET DIVERGENTS DE LA GROSSESSE ET DE LA MALIGNITE A Symposium tribute to Dr. Peeyush K. Lala / Un symposium dédié au Dr. Peeyush K. Lala Jing-Chuan Zhang, Xiaoping Qi, Jose’ Juarez, Marian Plunkett, Fernando Donaté, Ramasamy Sakthivel, Andrew P. Mazar, and Keith R. McCrae Inhibition of angiogenesis by two-chain high molecular weight kininogen (HKa) and kininogen-derived polypeptides Bruce E. Elliott, Wesley L. Hung, Alexander H. Boag, and Alan B. Tuck The role of hepatocyte growth factor (scatter factor) in epithelial-mesenchymal transition and breast cancer 91 Gendie E. Lash, Lynne-Marie Postovit, Nicola E. Matthews, Eugene Y. Chung, Matthew T. Canning, Hugh Pross, Michael A. Adams, and Charles H. Graham Oxygen as a regulator of cellular phenotypes in pregnancy and cancer 103 Can. J. Physiol. Pharmacol. Vol Gerald M. Kidder Trophectoderm development and function: the roles of Na*/K*-ATPase subunit isoforms Chandan Chakraborty, Louise M. Gleeson, Timothy McKinnon, and Peeyush K. Lala Regulation of human_ trophoblast migration and invasiveness Lorraine C. Jadeski, Chandan Chakraborty, and Peeyush K. Lala Role of nitric oxide in tumour progression with special reference to a murine breast cancer model Christian C.G. Naus Gap juncticns and tumour progression P.K. Lala, B.P. Lee, G. Xu, and C. Chakraborty Human placental trophoblast as an in vitro model for tumor progression REGULAR ARTICLES / ARTICLES REGULIERS Fernand Gobeil Jr., Stéphanie Hallé, Paul-André Blais, and Domenico Regoli Studies on the angiotensin-converting enzyme and the kinin B, receptor in the rabbit jugular vein: modulation of contractile response to bradykinin Analicia Rampazzo Xavier, José Eduardo de Salles Roselino, Neusa Maria Zanon Resano, Maria Antonieta Rissato Garofalo, Renato Helios Migliorini, and Isis do Carmo Kettelhut Glyconeogenic pathway in isolated skeletal muscles of rats March / mars ARTICLES / ARTICLES Yi He and Kathleen M. MacLeod Modulation of noradrenaline-induced vasoconstriction in isolated perfused mesenteric arterial beds from obese Zucker rats in the presence and absence of insulin Carl I. Thompson, John W. Munford, Edward H. Buell, Robert J. Karry, Charles T. Lee, Benjamin L. Morgan, and Alexander J. Radnovich Plasma constituents and mortality in rat pups given chronic insulin via injection, pellet, or osmotic minipump A.C. de Oliveira, V. D’ Almeida, D.C. Hipdélide, J.N. Nobrega, and S. Tufik Sleep deprivation reduces total plasma homocysteine levels in rats Bachtiar Indra, Kimihiro Matsunaga, Osamu Hoshino, Masaji Suzuki, Hiromichi Ogasawara, Masaji Ishiguro, and Yasushi Ohizumi_ Structure—activity relationship on (+)-nantenine derivatives in antiserotonergic activities in rat aorta S.W. Ball, J.R. Bailey, J.M. Stewart, C.M. Vogels, and S.A. Westcott A fluorescent compound for glucose uptake measure ments in isolated rat cardiomyocytes Y.K. Gupta, Geeta Chaudhary, and Kusum Sinha Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat Danica Brousseau, Jean-Francois Desjardins, Gaétan Jasmin, and Louis Dumont Altered coronary and cardiac adrenergic response in the failing hamster heart: role of cyclooxygenase derivatives Frédéric Canini, Nadine Simler, and Lionel Bourdon MK80! impairs thermoregulation in the heat Candace B. Matthew, Ingrid V. Sils, and Amy M. Bastille —Tissue-specific extravasation of albumin-bound Evans blue in hypothermic and rewarmed rats April / avril PEPTIDE RECEPTORS SYMPOSIUM - MONTREAL 2001: FROM GENE TO THERAPY (PART 1 OF 2) / SYMPOSIUM SUR LES RECEPTEURS DES PEPTIDES - MONTREAL 2001 : DU GENE A LA THERAPIE (PARTIE 1 DE 2) PREFACE / PREFACE Domenico Regoli, Rémi Quirion, Réjean Couture KININ SYSTEM / SYSTEME DES KININES Hiromoto Iwadate, Motoshige Kudo, and Kazuyuki Kizuki Expression of tissue kallikrein mRNA in developing rat brains Hudson de Sousa Buck, Brice Ongali, Gaétan Thibault, Charles J. Lindsey, and Réjean Couture Autoradiographic detection of kinin receptors in the human medulla of control, hypertensive, and diabetic donors F. Qadri, W. Hauser, O. Jéhren, and P. Dominiak Kinin B, and B, receptor mRNA expression in the hypothalamus of sponta neously hypertensive rats Glenn S. Mason, Michael J. Cumberbatch, Raymond G. Hill, and Nadia M.J. Rupniak The bradykinin B, receptor antago- nist B9858 inhibits a nociceptive spinal reflex in rabbits Contents / Sommaire Laimute Taraseviciene-Stewart, Lajos Gera, Peter Hirth, Norbert F. Voelkel, Rubin M. Tuder, and John M. Stewart A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model John M. Stewart, Lajos Gera, Daniel C. Chan, Paul A. Bunn, Jr., Eunice J. York, Vitalija Simkeviciene, and Barbara Helfrich Bradykinin-related compounds as new drugs for cancer and inflammation V. Camarda, A. Rizzi, G. Calo, K. Wirth, and D. Regoli Pharmacological characterisation of novel kinin B, receptor ligands Witold Neugebauer, Paul A. Blais, Stephanie Hallé, Catherine Filteau, Domenico Regoli, and Fernand Gobeil Jr. Kinin B receptor antagonists with multi-enzymatic resistance properties S. Meini, A. Lecci, F. Carini, M. Tramontana, S. Giuliani, C.A. Maggi, R. Ricci, G. Fabbri, B. Anichini, N. Harmat, A. Rizzi, V. Camarda, D. Regoli, and L. Quartara_ In vitro and in vivo activity of analogues of the kinin B, receptor antagonist MEN11270 Stefania Meini, Paola Cucchi, Sabrina Zappitelli, Luigi Rotondaro, Laura Quartara, Alessandro Giolitti, and Carlo Alberto Maggi Preliminary mutational analysis of the human kinin B, receptor for nonpeptide antagonist ligands recognition F. Carini, M. Guelfi, A. Lecci, M. Tramontana, S. Meini, S. Giuliani, X. Montserrat, J. Pascual, G. Fabbri, R. Ricci, L. Quartara, and C.A. Maggi Cardiovascular effects of peptide kinin B, receptor antagonists in rats Isabelle Maltais, Magdalena Bachvarova, Pierre Maheux, Patrice Perron, Francois Marceau, and Dimcho Bachvarovy Bradykinin B, receptor gene polymorphism is associated with altered urinary albumin/creatinine values in diabetic patients Marilyne Mage, Christiane Pécher, Eric Neau, Eric Cellier, Marina L. Dos Reiss, Joost P. Schanstra, Réjean Couture, Jean-Loup Bascands, and Jean-Pierre Girolami Induction of B, receptors in streptozotocin diabetic rats: possible involve ment in the control of hyperglycemia-induced glomerular Erk | and 2 phosphorylation A.H.M. Cardozo, D.A. Cabrini, M.M. Campos, G.A. Rae, J.P. Huidobro-Toro, and J.B. Calixto Diabetes-induced changes in responsiveness of rat bladder and vas deferens to peptides in vitro: susceptibility to reversal by insulin Eric Cellier, Johan Duchéne, Christiane Pécher, Céline Alric, Jean-Loup Bascands, Joost Peter Schanstra, and Jean-Pierre Girolami_ B, receptor activation reduces Erkl and Erk2 phosphorylation induced by insulin-like growth factor-I, platelet-derived growth factor-BB, and high glucose in rat isolated glomeruli Anthony J. Turner, Sarah R. Tipnis, Jodie L. Guy, Gillian I. Rice, and Nigel M. Hooper ACEH/ACE2 is a novel mamma lian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors Bernward A. Schélkens and Wolfgang Landgraf ACE inhibition and atherogenesis Valfredo Schlemper and Joao B. Calixto Mechanisms underlying the contraction induced by bradykinin in the guinea pig epithelium-denuded trachea May / mai PEPTIDE RECEPTORS SYMPOSIUM - MONTREAL 2001: FROM GENE TO THERAPY (PART 2 OF 2) / SYMPOSIUM SUR LES RECEPTEURS DES PEPTIDES - MONTREAL 2001 : DU GENE A LA THERAPIE (PARTIE2 DE 2) VARIOUS PEPTIDERGIC SYSTEMS / DIVERSITE DES SYSTEMES PEPTIDERGIQUES S.D. Katugampola, J.J. Maguire, R.E. Kuc, K.E. Wiley, and A.P. Davenport Discovery of recently adopted orphan receptors for apelin, urotensin II, and ghrelin identified using novel radioligands and functional role in the human cardiovascular system Louis M. Luttrell Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors Craig Giragossian, Maria Pellegrini, and Dale F. Mierke NMR studies of CCK-8/CCK, complex support membrane-associated pathway for ligand-receptor interaction Jean A. Boutin, Thomas Suply, Valérie Audinot, Marianne Rodriguez, Philippe Beauverger, Jean-Paul Nicolas, Jean-Pierre Galizzi, and Jean-Luc Fauchére Melanin-concentrating hormone and its receptors: state of the art James E. Blevins, Michael W. Schwartz, and Denis G. Baskin Peptide signals regulating food intake and energy homeostasis R. Bigoni, G. Calo, A. Rizzi, H. Okawa, D. Regoli, D. Smart, and D.G. Lambert Effects of naloxone benzoylhydrazone on native and recombinant nociceptin/orphanin FQ receptors ANGIOTENSIN SYSTEM / SYSTEME DES ANGIOTENSINES BRIEF REPORT / RAPPORT BREF Claudio M. Costa-Neto, Ayumi A. Miyakawa, Joao B. Pesquero, Laerte Oliveira, Siv A. Hjorth, Thue W. Schwartz, and Antonio C.M. Paiva Interaction of a non-peptide agonist with angiotensin Il AT, receptor mutants CQan n. J. Physiol. Pharmacol. Vol ARTICLES / ARTICLES M. Deraét, L. Rihakova, A. Boucard, J. Pérodin, S. Sauvé, A.P. Mathieu, G. Guillemette, R. Leduc, P. Lavigne, and E. Escher Angiotensin II is bound to both receptors AT, and AT , parallel to the transmembrane domains and in an extended form Silvana Aparecida Alves Correa, Lucimar Pereira Franca, Claudio Miguel Costa-Neto, Laerte Oliveira, Antonio Cechelli Mattos Pai°v a, and S. uma [mura S“h2:i muta Relevant role of Leu~”” 265 in helix VI of the angiotensin AT, receptor in agonist bind ing and activity Joao B. Pesquero, Debora R. Fior-Chadi, Yun-Guo Yu, Antonio J. Merjan, Charles J. Lindsey, and Antonio C.M. Paiva Systemic site of action for pressor effect of angiotensin II injected into the fourth cerebral ventricle of rats? ENDOTHELIN SYSTEM / SYSTEME DES ENDOTHELINES Arco Y. Jeng, Paul Mulder, Aij-Lie Kwan, and Bruno Battistini Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications Dung Pham, Arco Y. Jeng, Sylvain Plante, Emanuel Escher, and Bruno Battistini Inhibition of endothelin-converting enzyme for protection against neointimal proliferation following balloon angioplasty of the rat carotid artery Alcibia M. Cardozo, Pedro D’Orléans-Juste, Ghassan Bkaily, and Giles A. Rae Simultaneous changes in intracellular calcium and tension induced by endothelin-! and sarafotoxin S6c in guinea pig isolated gallbladder: influence of indomethacin Gary M. Ksander, Suraj S. Shetty, Dominick DelGrande, Joseph L. Balwierczak, Charles W. Bruseo, Paula Savage, Reynalda deJesus, Andrew Yuan, Randy L. Webb, and Arco Y. Jeng Dipeptide sulfonamides as endothelin ET,/ETp, receptor antag onists Paula Savage and Arco Y. Jeng Upregulation of endothelin-1 binding in tissues of salt-loaded stroke-prone spontaneously hy pertensive rats NEUROKININ SYSTEM / SYSTEME DES NEUROKININES Pranela Rameshwar, Pedro Gascon, Persis S. Bandari, Deval D. Joshi, Annemarie Fernandes, and Anju Dang Structural similarity between the bone marrow extracellular matrix protein and neurokinin | could be the limiting factor in the hematopoietic effects of substance P Xavier Emonds-Alt, Vincenzo Proietto, Régis Steinberg, Charles Advenier, Samira Daoui, Emmanuel Naline, Christiane Gueudet, Jean-Claude Michaud, Florence Oury-Donat, Martine Poncelet, Pol Vilain, Gérard Le Fur, Jean-Pierre Maffrand, Philippe Soubrié, and Marc Pascal Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK; receptor antagonist CRITICAL REVIEW / SYNTHESE CRITIQUE Nadia M.J. Rupniak New insights into the antidepressant actions of substance P (NK, receptor) antagonists ARTICLE / ARTICLE J.V. Priestley, G.j. Michael, S. Averill, M. Liu, and N. Willmott Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor June / juin ARTICLES / ARTICLES G. Banos, F. Martinez, J.1. Grimaldo, and M. Franco Adenosine participates in regulation of smooth muscle relaxation in aortas from rats with experimental hypothyroidism Banafsheh Moazed and M. Desautels _Differentiation-dependent expression of cathepsin D and importance of lysosomal proteolysis in the degradation of UCP! in brown adipocytes Bruno Melin, Chantal Jimenez, Nathalie Koulmann, Anne-Marie Allevard, and Claude Gharib Hyperhydration induced by glycerol ingestion: hormonal and renal responses Michael H.I. Shiue, Hovhannes J. Gukasyan, Kwang-Jin Kim, Donald D.F. Loo, and Vincent H.L. Lee Characterization of cyclic AMP-regulated chloride conductance in the pigmented rabbit conjunctival epithelial cells Bita Moazed and M. Desautels Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, phosphatidylinositol 3-kinase, and p70 S6K Nathalie Berthon, Pascal Laurant, Daniel Hayoz, Dominique Fellmann, Hans R. Brunner, and Alain Berthelot Magnesium supplementation and deoxycorticosterone acetate — salt hypertension: effect on arterial mechanical properties and on activity of endothelin-| Sommaire E.J. Verspohl, B. Johannwille, A. Waheed, and H. Neye Effect of purinergic agonists and antagonists on insulin secretion from INS-1 cells (insulinoma cell line) and rat pancreatic islets S.A. Reading and J.K. Barclay The inotropic effect of nitric oxide on mammalian papillary muscle is dependent on the level of §,-adrenergic stimulation Maria de Jesis Gomez, Guy Rousseau, Réginald Nadeau, Roberto Berra, Gonzalo Flores, and Jorge Suarez Functional and autoradiographic characterization of dopamine D,-like receptors in the guinea pig heart Marguerite A. Stout, Luc Raeymaekers, Humbert De Smedt, and Rik Casteels Characterization of Ca~* release from hetero geneous Ca“ stores in sarcoplasmic reticulum isolated from arterial and gastric smooth muscle BRIEF REPORT / RAPPORT BREF George A. Gerencser, Randy . Levin, and Jianliang= Zhang= PhospIh ate absorption by- Atp lysia californica ég ut: thy¢ roid hormone stimulation July / juillet RADIATION EFFECTS ON DNA AND CHROMATIN / EFFETS DES RAYONNEMENTS SUR L'ADN ET SUR LA CHROMATINE Corinne Maufrais and Yves Boulard Solution structure of a DNA duplex containing a formamide—adenine base pair P. Jacquet, J. Buset, J. Vankerkom, S. Baatout, L. de Saint-Georges, W. Schoonjans, and C. Desaintes Mouse one-cell em- bryos undergoing a radiation-induced G2 arrest may re-enter S-phase in the absence of cytokinesis Liliana Radu, B. Constantinescu, and Doina Gazdaru Effects of fast neutrons on chromatin: dependence on chromatin struc- ture APOPTOSIS / APOPTOSE Sarah Baatout, Hanane Derradji, Olivier Petitfour, Hanna von Suchodoletz et Max Mergeay Mécanismes de | apoptose racio-induite C. Didelot, J.F. Mirjolet, M. Barberi-Heyob, C. Ramacci, and J.L. Merlin Radiation could induce p53-independent and cell cycle - unrelated apoptosis in 5-fluorouracil radiosensitized head and neck carcinoma cells D. Coelho, B. Fischer, V. Holl, P. Dufour, J.M. Denis, J. Gueulette, J.P. Bergerat, and P. Bischoff Induction of apoptosis by high linear energy transfer radiation: role of p53 D.O. Cliche, 8. Girouard, N. Bissonnette, and D.J. Hunting — Inhibition of ultraviolet B (UVB) induced apoptosis in A431 cells by mimosine is not dependent on cell cycle arrest D. Pusset, M. Fromm, J.L. Poncy, B. Kantelip, P. Galle, A. Chambaudet, M. Baud, and H. Boulahdour Ultrastructural lesions induced by neptunium-237: apoptosis or necrosis? OXIDATIVE STRESS / STRESS OXYDATIF Abdelouahed Khalil Mécanisme moléculaire de effet protecteur de la vitamine E dans l’athérosclérose RADIOPATHOLOGY / RADIOPATHOLOGIE Michel Diserbo, Arnaud Agin, loannis Lamproglou, Jéréme Mauris, Fatiha Staali, Eric Multon, and Christine Amourette Blood—brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study i. Lamproglou, F. Baillet, G. Boisserie, J.J. Mazeron et J.Y. Delattre Influence de lage sur les troubles cognitifs radio-induits études expérimentales avec irradiation cérébrale de 30 Gy en 10 séances et 12 jours chez le rat Wistar de 1, 5, 4 et 18 mois F. Lebrun, M. Benderitter, A. Berroud, P. Voisin, and N.M. Griffiths Potential role of the membrane in the development of intestinal cellular damage after whole-body gamma irradiation of the rat TREATMENT OF RADIATION-INDUCED BONE MARROW APLASIA / TRAITEMENT DE L'APLASIE MEDULLAIRE RADIO-INDUITE T. de Revel, T. Fagot, B. Souleau, D. Dormont et G. Nedellec L’aplasie médullaire secondaire 4 un accident d’ irradiation : op- tions thérapeutiques et évolution des concepts M. Drouet, F. Mourcin, N. Grenier, J.F. Mayol, V. Leroux, J.J. Sotto et F. Hérodin Effet des rayonnements ionisants sur les cellules souches et progéniteurs hématopoiétiques : place de l’apoptose et intérét thérapeutique potentiel des traitements antiapoptotiques F. Hérodin and M. Drouet Autologous cell therapy as a new approach to treatment of radiation-induced bone marrow aplasia: preliminary study in a baboon model Can. J. Physiol. Pharmacol. Vol. 80, 2002 Marc-André Mouthon, Anne Van der Meeren, Marie Vandamme, Claire Squiban, and Marie-Héléne Gaugler Thrombopoietin protects mice from mortality and myelosuppression following high-dose irradiation: importance of time scheduling RADIOTOXICOLOGY / RADIOTOXICOLOGIE P. Fritsch, N. Dudoignon, K. Guillet, G. Rateau et J. Delforge Influence de la distribution de dose sur le risque d’ apparition de cancers pulmonaires aprés inhalation d’oxydes d’actinides B. Ramounet-Le Gall, P. Fritsch, M.C. Abram, G. Rateau, G. Grillon, K. Guillet, S. Baude, P. Bérard, E. Ansoborlo et J. Delforge Mesure de paramétres spécifiques pour le calcul de dose aprés inhalation d’aérosols renfermant des éléments transuraniens H. Tymen, G. Rateau, K. Guillet, B. Ramounet-Le Gall, P. Gérasimo et P. Fritsch Méthodes de mesure du transfert cutané des radionucléides au travers d'un épiderme intact ou lésé, application a la radiotoxicologie RADIOADAPTATION / RADIOADAPTATION Ileana Petcu, Nicoleta Moisoi, Diana Savu, and B. Constantinescu Effect of pre-exposure to B rays of tritium on some bio- chemical parameters measured in organs of rats subsequently irradiated with fast neutrons RADIATION SOURCE / SOURCE DE RAYONNEMENT B. Verrey, Y. Leo et P. Fouillaud Réacteur Silene : outil adapté aux études appliquées a l’effet des moyennes et fortes doses August / aoat RAPID COMMUNICATION / COMMUNICATION RAPIDE Mahua Ghosh, Hui Di Wang, and J. Robert McNeill Tiron exerts effects unrelated to its role as a scavenger of superoxide anion: effects on calcium binding and vascular responses ARTICLES / ARTICLES S. Hosein, G.S. Marks, J.F. Brien, B.E. McLaughlin, and K. Nakatsu An extracellular source of heme can induce a signifi- cant heme oxygenase mediated relaxation in the rat aorta Mahmoud M. El-Mas, Elham A. Afify, Amal G. Omar, and Fouad M. Sharabi Cyclosporine attenuates the autonomic mod- ulation of reflex chronotropic responses in conscious rats Masa-aki Hattori, Yukio Kato, and Noboru Fujihara Retinoic acid suppression of endothelial nitric oxide synthase in porcine oocyte Elisangela Farias-Silva, Marilia M. Sampaio-Barros, Maria E.C. Amaral, Everardo M. Carneiro, Antonio C. Boschero, Dora M. Grassi-Kassisse, and Regina C. Spadari-Bratfisch Subsensitivity to insulin in adipocytes from rats submitted to foot-shock stress Shirley C. Paski and Zhaoming Xu Growth factor stimulated cell proliferation is accompanied by an elevated labile intracellular pool of zinc in 3T3 cells Jean-Claude Launay, Yves Besnard, Angélique Guinet, Germain Bessard, Christian Raphel, and Gustave Savourey Effects of modafinil on heat thermoregulatory responses in humans at rest Mark W. Huang, Peter M. Scholz, and Harvey R. Weiss Increases in myocardial cyclic GMP attenuate contractile delay in myocardial stunning Maria A.G. Reid, Martin G. Latour, Dallas J. Legare, Na Rong, and W. Wayne Lautt Comparison of the rapid insulin sen- sitivity test (RIST), the insulin tolerance test (ITT), and the hyperinsulinemic euglycemic clamp (HIEC) to measure insulin action in rats Andrea Vovk, David A. Cunningham, John M. Kowalchuk, Donald H. Paterson, and James Duffin Cerebral blood flow re- sponses to changes in oxygen and carbon dioxide in humans BRIEF REPORT / RAPPORT BREF Yukihisa Miyachi, Takahisa Koike, Kenzo Muroi, Tomoko Kanao, Taro Kawamoto, and Takeshi Yamada Marked depression of radiation-induced emesis in frogs following prior exposure to a brief dose of X-rays ERRATUM / ERRATUM Candace B. Matthew, Ingrid V. Sils, and Amy M. Bastille Erratum: Tissue-specific extravasation of albumin-bound Evans blue in hypothermic and rewarmed rats Contents / Sommaire September / septembre CURRENT CONCEPTS / CONCEPTS COURANTS Mogamat Razeen Davids, Yeouda Edoute, Robert L. Jungas, Surinder Cheema-Dhadli, and Mitchell L. Halperin Facilitating an understanding of integrative physiology: emphasis on the composition of body fluid compartments ARTICLES / ARTICLES Vanessa Leung and Wally Bartfay Investigations into the systemic production of aldehyde-derived peroxidation products in a murine model of acute iron poisoning: a dose response study Jean-Claude Launay, Yves Besnard, Angélique Guinet, Anne-Marie Hanniquet, Jacques Bittel, and Gustave Savourey rhermoregulation in the cold after physical training at different ambient air temperatures Anabelle M. Opazo Saez, R. Robert Schellenberg, Mara S. Ludwig, Richard A. Meiss, and Peter D. Paré Tissue elastance influences airway smooth muscle shortening: comparison of mechanical properties among different species B.M. Chung, L.E. Wallace, J.A. Hardin, and D.G. Gall The effect of epidermal growth factor on the distribution of SGLT-1 in rabbit jejunum Arthur S. Brecher and Eric L. Hommema_ The influence of acetaldehyde and glycosaminoglycans upon Factor Xa- and Factor X-deficient plasma Douglas A. Syme and Michael J. Grattan Effects of stretch on work from fast and slow muscles of mice: damped and un- damped energy release José H. Leal-Cardoso, Saad Lahlou, Andrelina N. Coelho-de-Souza, David N. Criddle, Gloria I.B. Pinte Duarte, Marcia A.V. Santos, and Pedro J.C. Magalhaes Inhibitory actions of eugenol on rat isolated ileum Amitava Das, Madhu Dikshit, Shoba R. Srivastava, Umesh K. Srivastava, and Chandishwar Nath Effect of ovariectomy and estrogen supplementation on brain acetylcholinesterase activity and passive-avoidance learning in rats Christian Klausen, John P. Chang, and Hamid R. Habibi Time- and dose-related effects of gonadotropin-releasing hormone on growth hormone and gonadotropin subunit gene expression in the goldfish pituitary C.B. Matthew, A.M. Bastille, R.R. Gonzalez, and I.V. Sils Heart rate variability and electrocardiogram waveform as predictors of morbidity during hypothermia and rewarming in rats October / octobre ARTICLES / ARTICLES Gary D. Niehaus, Elyce Ervin, Amit Patel, Kamal Khanna, Vincent W. Vanek, and Diana L. Fagan Circadian variation in cell-adhesion molecule expir ession by; normal human leukocy\t es P.D. Chilibeck, K.S. Davison, S.J. Whiting, Y. Suzuki, C.L. Janzen, and P. Peloso § The effect of strength training combined with bisphosphonate (etidronate) therapy on bone mineral, lean tissue, and fat mass in postmenopausal women Julie Lacombe, Ekaterina Viazovkina, Pascal N. Bernatchez, Annie Galarneau, Masad J. Damha, and Martin G. Sirois Antisense inhibition of FIk-1 by oligonucleotides composed of 2'-deoxy-2’-fluoro-B -D-arabino- and 2'-deoxy-nucleosides Erika R. Vera, Mary L. Battell, Sanjay Bhanot, and John H. McNeill Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats 962 S. Magder Theoretical analysis of the noncardiac limits to maximum exercise 971 Subodh Verma, Emi Arikawa, Sammy Lee, Aaron S. Dumont, Linfu Yao, and John H. McNeill Exaggerated coronary reactivity to endothelin-! in diabetes: reversal with bosentan 980 Steven J. Compton, John J. McGuire, Mahmoud Saifeddine, and Morley D. Hollenberg Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta 987 Dilson E. Rassier and Brian R. MacIntosh Length-dependent twitch contractile characteristics of skeletal muscle 993 Mark Grist, Richard B. Wambolt, Gregory P. Bondy, Dean R. English, and Michael F. Allard Estrogen replacement stimu- lates fatty acid oxidation and impairs post-ischemic recovery of hearts from ovariectomized female rats 1001 Brian D. Roy, Jacqueline M. Bourgeois, Douglas J. Mahoney, and Mark A. Tarnopolsky Dietary supplementation with creatine monohydrate prevents corticosteroid-induced attenuation of growth in young rats 1008 Ju-Feng Wang, Xinhua Yan, Jiangyong Min, Matthew F. Sullivan, Thomas G. Hampton, and James P. Morgan Cocaine downregulates cardiac SERCA2a and depresses myocardial function in the murine model 1015 Can. J. Physiol. Pharmacol. Voi. 80, 2002 Liliana Romano, Alfredo Coviello, Susana Jerez, and Maria Peral de Bruno’ Role of nitric oxide on the vasorelaxant effect of atrial natriuretic peptide on rabbit aorta basal tone BRIEF REPORT / RAPPORT BREF David L. Zhou and David D. Kitts Peripheral blood mononuclear cell production of TNF-a in response to North American gin- seng stimulation 1030 November / novembre SURVEY REVIEW / SYNTHESE D’ENSEMBLE Jean-Mare Lavoie The contribution of afferent signals from the liver to metabolic regulation during exercise ARTICLES / ARTICLES S.M. Phillips, G. Parise, B.D. Roy, K.D. Tipton, R.R. Wolfe, and M.A. Tarnopolsky — Resistance-training-induced adaptations in skeletal muscle protein turnover in the fed state 1045 Jintana Meesungnoen, Jean-Paul Jay-Gerin, and Samlee Mankhetkorn Relation between MDR/ mRNA levels, resistance factor, and the efficiency of P-glycoprotein-mediated efflux of pirarubicin in multidrug-resistant K562 sublines 1054 J.A. Hardin, L. Donegan, R.C. Woodman, C. Trevenen, and D.G. Gall Mucosal inflammation in a genetic model of sponta- neous type I diabetes mellitus 1064 Adriana Rocha, Eduardo Barbosa Coelho, and Vera Lucia Lanchote Stereospecific disposition of fluvastatin in streptozotocin-induced diabetic rats 1071 Sampath Madhyastha, S.N. Somayaji, M.S. Rao, K. Nalini, and K. Laxminarayana Bairy Hippocampal brain amines in methotrexate-induced learning anc memory deficit 1076 P. Larsen, E. Schleihauf, H. Yu, T. Prior, and P.K. Rangachari Calcium-stimulated short-circuit currents in the canine proximal coionic epithelium: effects of DK-PGD,, a metabolite of prostaglandin D, 1085 Kelly A. Meckling, Melanie Gauthier, Rebecca Grubb, and Jennifer Sanford Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids, blood pressure, glucose tolerance, and body composition in free-living overweight women 1095 Jodan D. Ratz, Michael A. Adams, and Brian M. Bennett Effect of in vivo nitrate tolerance on hypersensitivity to NO donors after NO-synthase blockade 1196 BRIEF REPORT / RAPPORT BREF Adnan Ali and John J. Heikkila Enhanced accumulation of constitutive heat shock protein mRNA is an initial response of eye tissue to mild hyperthermia in vivo in adult Xenopus laevis December / décembre ARTICLES / ARTICLES Saad Lahlou, André Fernandes Figueiredo, Pedro Jorge Caldas Magalhaes, and José Henrique Leal-Cardoso Cardiovas- cular effects of 1,8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats Timothy J. Bloom Cyclic nucleotide phosphodiesterase isozymes expressed in mouse skeletal muscle J.K. Shoemaker, A. Vovk, and D.A. Cunningham Peripheral chemoreceptor contributions to sympathetic and cardiovascular re- sponses during hypercapnia Cindy Tissier, Sandrine Bes, David Vandroux, Elisabeth Fantini, Luc Rochette, and Pierre Athias Specific electromechani- cal responses of cardiomyocytes to individual and combined components of ischemia Yoko Hagino and Masayuki Watanabe — Effects of clozapine on the efflux of serotonin and dopamine in the rat brain: the role of 5-HT; 4 receptors Qin Li, M. Martha Briggs, Doris Folkens, and Ceredwyn E. Hill Models of depressed hepatic mrp2 activity reveal bromosulphophthalein-sensitive passive K* flux H.F. Miranda, F. Sierralta, and G. Pinardi Carbachol interactions with nonsteroidal anti-inflammatory drugs Douglas S. Martin, J.L. Williams, Nikolai P. Breitkopf, and Kathleen M. Eyster Pressor responsiveness to angiotensin in soy-fed spontaneously hypertensive rats Yu-Jun Cai, Jin-Qiu Dai, Jian-Guo Fang, Lan-Ping Ma, Li-Fen Hou, Li Yang, and Zhong-Li Liu Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata Contents / Sommaire BRIEF REPORTS / RAPPORTS BREFS George A. Gerencser, Kuuleialoha M. Cornette, and Jianliang Zhang Thyroid-hormone-induced phosphate absorption in Aplysia californica gut is mediated through protein synthesis R.R. Ettarh, I.P. Odigie, and S.A. Adigun Vitamin C lowers blood pressure and alters vascular responsiveness in salt-induced hypertension RAPID COMMUNICATION / COMMUNICATION RAPIDE Bryan Simard, Bichoy H. Gabra, and Pierre Sirois Inhibitory effect of a novel bradykinin B, receptor antagonist, R-954, on enhanced vascular permeability in type | diabetic mice Note of appreciation / Note de reconnaissance Author Index for Volume 80 / Index des auteurs pour le volume 80 Contents for Volume 80 / Sommaire pour le volume 80

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