Canadian Journal of Revue canadienne Physiology and de physiologie Pharmacology et pharmacologie Volume 72, 1994 Contents / Sommaire JANUARY/ JANVIER ARTICLES G.S. Morris, P.V. Fiore, R.L. Hamlin, and W.M. Sherman Effects of long-term cocaine administration and exercise on cardiac metabolism and isomyosin expression William W. Simmons, Gordon W. Moe, Etienne A. Grima, Robert J. Howard, and Paul W. Armstrong Myocardial energetics and blood flow in acute rapid ventricular pacing Chi-Chung Chan, Christine Tousignant, Elaine Ho, Christine Brideau, Chantal Savoie, and Ian W. Rodger Evaluation of broncho- constriction induced by neurokinins and its inhibition by selective nonpeptide antagonists on conscious guinea pigs, using a double-chamber plethysmo- graph technique Yoshio Tanaka, Shinzo Hata, Hiromi Ishiro, Kunio Ishii, and Koichi Nakayama _ Stretching releases Ca** from intracellular storage sites in canine cerebral arteries Shinji Itoh, Akira Takashima, and Taketoshi Morimoto Impaired spatial learning by vasoactive intestinal peptide in Morris water maze task in the rat Christopher R. Forrest, Ning Xu, and Cho Y. Pang Evidence for nicotine-induced skin flap ischemic necrosis in the pig J.A. Walker, C.R. Krehbiel, D.L. Harmon, G. St. Jean, W.J. Croom, Jr., and W.M. Hagler, Jr. Effects of slaframine and 4-diphenylacetoxy-N-methylpiperidine methiodide (4DAMP) on pancreatic exocrine secretion in the bovine Christine Forster, George Naik, and Paul W. Armstrong Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog Ian Guest and Daya R. Varma __ Inhibition of mouse embryonic, yolk sac, and limb-bud functions by the methy] isocyanate metabolite S-(N-methyl- carbamoy])glutathione Ian Guest, Harpal S. Buttar, Susan Smith, and Daya R. Varma _ Evaluation of the rat embryo culture system as a predictive test for human teratogens B.L. Tepperman and B.D. Soper Effect of extracellular Ca2* on indomethacin-induced injury to rabbit dispersed gastric mucosal cells Louis W.C. Liu and Jan D. Huizinga Canine colonic circular muscle generates action potentials without the pacemaker component Flavio Coceani, Lois Kelsey, and Eric Seidlitz Occurrence of endothelium-derived relaxing factor — nitric oxide in the lamb ductus arteriosus J.A. Thornhill and I. Halvorson Electrical stimulation of the posterior and ventromedial hypothalamic nuclei causes specific activation of shivering and nonshivering thermogenesis K.H. Hoo, C.-Y. Kwan, and E.E. Daniel Investigation of a,-adrenoceptor subtypes in canine aorta, using alkylating agents BRIEF REPORT C.F. Kukel and K.R. Jennings Delphinium alkaloids as inhibitors of a-bungarotoxin binding to rat and insect neural membranes Instructions to authors Recommandations aux auteurs Publication Policy Politique de publication FEBRUARY/ FEVRIER ARTICLES E.G. Watson, J.E.T. Fox-Threlkeld, and E.E. Daniel Tachykinin-mediated increase in motility acts independently of vasoactive intestinal polypeptide release in the canine ileum Jacques LeBlanc and Julie Soucy Hormonal dose-response to an adenosine receptor agonist David J. Dyck and Lawrence L. Spriet Elevated muscle citrate does not reduce carbohydrate utilization during tetanic stimulation Judith Pignac, Jean Bourgouin, and Louis Dumont Cold cardioplegia and the K* channel modulator aprikalim (RP 52891): improved cardio- protection in isolated ischemic rabbit hearts C-1 C3 CAN. J. PHYSIOL. PHARMACOL. VOL. 72, 1994 B. Alnaif, R.J. Benzie, and W. Gibb Studies on the action of interleukin-1 on term human fetal membranes and decidua Yves Cottin, Christophe Ribuot, Véronique Maupoil, Diane Godin, Laurent Arnould, Francois Brunotte, and Luc Rochette Early incidence of adriamycin treatment on cardiac parameters in the rat Louise Béliveau, Francois Péronnet, Daniel G. Bichet, and Réginald Nadeau Atrial natriuretic peptide release from the ventricles in response to exercise in dogs with atrioventricular block Kenneth J. Broadley and Andrew N.A. Wilson Does endogenous adenosine have a role in the cardiac responses to isoprenaline and in the rapid fade of the inotropic response of perfused heart? G.L. Lou, C. Pinsky, and D.S. Sitar Kynurenic acid distribution into brain and peripheral tissues of mice Daniel Abran, Daya R. Varma, Ding-You Li, and Sylvain Chemtob Reduced responses of retinal vessels of the newborn pig to prostaglandins but not to thromboxane Darren E. Richard, Sylvie Bernier, Guylain Boulay, and Gaétan Guillemette Selective interaction of chemical dyes with inositol 1,4,5-trisphosphate recognition sites Luc Charette, Denise Foulon, Ian W. Rodger, and Thomas R. Jones Neurokinin (NK) receptors mediate nonadrenergic noncholinergic contractile responses to electrical stimulation and resiniferatoxin in guinea pig trachea Abstracts of the 26th Winter Meeting of the Canadian Physiological Society (Résumes de la 26° session d’hiver de la Société canadienne de physiologie) MARCH/ MARS ARTICLES N. Buljubasic, J. Marijic, J.P. Kampine, and Z.J. Bosnjak Calcium-sensitive potassium current in isolated canine coronary smooth muscle cells Tony R. Bai and F.W.F. Prasad Epithelial modulation of cholinergic responses in human tracheal smooth muscle P.G. Forkert and L. Forkert Trichloroethylene induces pulmonary fibrosis in mice Zhaoming Xu, E. James Squires, and Tammy M. Bray Effects of dietary zinc deficiency on the hepatic microsomal cytochrome P450 2B in rats Flavio Coceani, Lois Kelsey, Cameron Ackerley, Marlene Rabinovitch, and Harry Gelboin Cytochrome P450 during ontogenic development: occurrence in the ductus arteriosus and other tissues Mark Berner Hansen ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum 1.D. Martijena and A. Arce Transient benzodiazepine—GABA, receptor increase after a passive avoidance learning in synaptosomal membranes from chick forebrain Victor Lun, John C.L. Sun, Gordon G. Giesbrecht, and Igor B. Mekjavié Shivering thermogenesis during acute hypercapnia BRIEF REPORT / RAPPORT BREF Mary Jo LaDu and Warren K. Palmer Expression of lipoprotein lipase during differentiation of cultured L6 muscle cells SYMPOSIA OF THE CANADIAN FEDERATION OF BIOLOGICAL SOCIETIES SYMPOSIUMS DE LA FEDERATION CANADIENNE DES SOCIETES DE BIOLOGIE Nutrition and Gastrointestinal Development (Nutrition et développement gastro-intestinal) Windsor, Ontario, Canada June 18, 1993 / le 18 juin 1993 Randal K. Buddington Nutrition and ontogenetic development of the intestine Michael I. McBurney The gut: central organ in nutrient requirements and metabolism S.E. Fleming and C.E. Kight The TCA cycle as an oxidative and synthetic pathway is suppressed with aging in jejunal epithelial cells Circulation Windsor, Ontario, Canada June 17, 1993 / le 17 juin 1993 B. Mutus Introduction to the Circulation Symposium Marian A. Packham Role of platelets in thrombosis and hemostasis Adrian R.L. Gear Platelet adhesion, shape change, and aggregation: rapid initiation and signal transduction events Peter D. Winocour Platelets, vascular disease, and diabetes mellitus CONTENTS/SOMMAIRE Ytje Y. van der Hoek, John J.P. Kastelein, and Marlys L. Koschinsky Analysis of structure—function relationships in human apolipo- protein(s) APRIL/ AVRIL ARTICLES S.C. Mukaddam-Daher, G.W. Aberdeen, S.C. Cha, J. Gutkowska, B.S. Nuwayhid, and E.W. Quillen, Jr. Indirect hypertensive actions of long-term intracarotid angiotensin II infusion during ovine pregnancy Raymond Tsang, Ziliang Ao, and Chris Cheeseman Influence of vascular and luminal hexoses on rat intestinal basolateral glucose transport Ki Churl Chang, Won Seog Chong, and In Je Lee Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart Mark M. Kneupfer, Carrie A. Branch, David M. Wehner, Qi Gan, and Dung Hoang Nonadrenergic mechanisms of cocaine-induced regional vascular responses in rats Anita Matthias, Stephen M. Richards, Kim A. Dora, Michael G. Clark, and Eric Q. Colquhoun Characterization of perfused periaortic brown adipose tissue from the rat Nobuharu Yamaguchi and Louis Lamarche Adrenal medullary counterregulatory response to hypoglycemia in dogs with hepatic cross perfusion Arjumand Inayatulla, Ding-You Li, Sylvain Chemtob, and Daya R. Varma _ Ontogeny of positive inotropic responses to sympathomimetic agents and of myocardial adrenoceptors in rats S. Liske and M.E. Morris Extrasynaptic effects «“ GABA (y-aminobutyric acid) agonists on myelinated axons of peripheral nerve Anzhen Qi, Charles R. Kerr, and John A. Yeung-Lai-Wah_Electrophysiologic properties of a narrow isthmus in rabbit atrial tissue: cycle length dependent effect of quinidine Qi-Ying Liu and Mario Vassalle Mechanisms underlying the modulation of arrhythmogenic events by components of ischemia in guinea pig cardiac myocytes BRIEF REPORTS / RAPPORTS BREFS Keith J. Barrington, Robert G. Allen, and Jay W. Dewald Renal vascular effects of epinephrine infusion in the halothane-anesthetized piglet S.M. Kimmett, J.P. McNamee, and G.S. Marks Mechanism-based inactivation of hepatic cytochrome P450 2C6 and P450 3A1 following in vivo administration of 3,5-diethoxycarbonyl-1 ,4-dihydro-2 ,6-dimethyl-4-ethylpyridine to rats: differences from previously observed in vitro results SYMPOSIUM OF THE CANADIAN FEDERATION OF BIOLOGICAL SOCIETIES SYMPOSIUM DE LA FEDERATION CANADIENNE DES SOCIETES DE BIOLOGIE Biotechnology and Nutrition (Biotechnologie et nutrition) Windsor, Ontario, Canada June 17, 1993 / le 17 juin 1993 Peter J.H. Jones Introduction to the Biotechnology and Nutrition Symposium L. Savoie Digestion and absorption of food: usefulness and limitations of in vitro models M.J. Patricia Mazier and Peter J.H. Jones Model-based compartmental analyses in nutrition research David D. Kitts Bioactive substances in food: identification and potential usess I. Knight The development and applications of sucralose, a new high-intensity sweetener May/ Mal ARTICLES Rheal A. Towner, Lester A. Reinke, Edward G. Janzen, and Shigeto Yamashiro In vivo magnetic resonance imaging study of Kupffer cell involvement in CCl,-induced hepatotoxicity in rats Brian Rodrigues, Paul F. Grassby, Mary L. Battell, Stephanie Y.N. Lee, and John H. McNeill Hypertriglyceridemia in experimental diabetes: relationship to cardiac dysfunction Maria Elena Sales and Enri S. Berda_ Uterine 6-adrenergic receptors in allogeneic and syngeneic pregnancy Stephanie W. Watts, Kathryn W. Schenck, and Marlene L. Cohen Selective desensitization of 5-hydroxytryptamine 2A receptor mediated contraction in guinea pig trachea Fereidon K. Alavi, Joseph P. McCann, Subbiah Sangiah, and Cyril R. Clarke Effect of dietary obesity on naloxone disposition in sheep RAPID COMMUNICATION / COMMUNICATION RAPIDE D.V. Rayner, Moira E.A. Thomas, and Paul Trayhurn Glucose transporters (GLUTs 1 —4) and their mRNAs in regions of the rat brain: insulin-sensitive transporter expression in the cerebellum CAN. J. PHYSIOL. PHARMACOL. VOL. 72, 1994 SYMPOSIUM OF THE CENTRE DE RECHERCHE EN SCIENCES NEUROLOGIQUES SYMPOSIUM DU CENTRE DE RECHERCHE EN SCIENCES NEUROLOGIQUES Sensorimotor Control of the Hand (Contréle sensorimoteur de la main) Montréal, Quebec, Canada May 6 and 7, 1993 / le 6 et 7 mai 1993 MAIN INTRODUCTION / INTRODUCTION D'OUVERTURE C. Elaine Chapman and Allan M. Smith Sensorimotor Control of the Hand Peripheral Mechanisms of Touch and Proprioception (Mécanismes périphériques du toucher et de la proprioception) Lynette A. Jones Introduction I. Peripheral Mechanisms of Touch and Proprioception Kenneth O. Johnson and Steven S. Hsiao Evaluation of the relative roles of slowly and rapidly adapting afferent fibers in roughness perception Robert H. LaMotte, Mandayam A. Srinivasan, Charles Lu, and Andreas Klusch-Petersen Cutaneous neural codes for shape The Adaptive Control of Prehension (Le contréle adaptatif de la préhension) Susan J. Lederman Introduction II. The Adaptive Control of Prehension Roland S. Johansson and Kelly J. Cole Grasp stability during manipulative actions David J. Bennett, Monica Gorassini, and Arthur Prochazka Catching a ball: contributions of intrinsic muscle stiffness, reflexes, and higher order responses M. Jeannerod The hand and the object: the role of posterior parietal cortex in forming motor representations Central Neural Mechanisms of Touch and Proprioception (Mécanismes neuro-centraux du toucher et de la proprioception) John F. Kalaska Introduction III. Central Neural Mechanisms of Touch and Proprioception Harold Burton and Robert J. Sinclair Representation of tactile roughness in thalamus and somatosensory cortex C. Elaine Chapman Active versus passive touch: factors influencing the transmission of somatosensory signals to primary somatosensory cortex M.-C. Hepp-Raymond, E.J. Hiisler, M.A. Maier, and H.-X. Qi Force-related neuronal activity in two regions of the primate ventral premotor cortex Central Neural Mechanisms of Prehension (Mécanismes neuro-centraux de la préhension) Donald G. Lawrence Introduction IV. Central Neural Mechanisms of Prehension Allan M. Smith Some shear facts and pure friction related to roughness discrimination and the cutaneous control of grasping Mario Wiesendanger, Pawel Kaluzny, Oleg Kazennikov, Agostino Palmeri, and Stephen Perrig Temporal coordination in bimanual actions JUNE/ JUIN ARTICLES R. Chahine, R. Nadeau, D. Lamontagne, N. Yamaguchi, and J. de Champlain Norepinephrine and dihydroxyphenylglycol effluxes from sympathetic nerve endings during hypoxia and reoxygenation in the isolated rat heart Paul S. Sunga and Simon W. Rabkin Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet Randall G. Leeder, James F. Brien, and Thomas E. Massey _ Investigation of the role of oxidative stress in amiodarone-induced pulmonary toxicity in the hamster Jiahua Jiang, Kyosuke Temma, and Tai Akera Doxorubicin-induced changes in intracellular Ca** transients observed in cardiac myocytes isolated from guinea-pig heart Al-Hassan Badahman and Thomas W. Wilson A renal vasodilator effect of angiotensin II revealed by dual thromboxane inhibition N. Ashton, C.G. Clarke, D.E. Eddy, and F.V. Swift Mechanisms involved in the activation of ischemically sensitive, afferent renal nerve mediated reflex increases in hindlimb vascular resistance in the anesthetized rabbit J.C. Ruf, M. Ciavatti, T. Gustafsson, and S. Renaud In vitro effect of p-myo-inositol 1,2,6-trisphosphate (PP-56) on aggregation of platelets from normal and diabetic rats: relationship to malondialdehyde release and phosphoinositide pathway Ricardo Lopez-Escalera, Robert J. French, and Paul P.M. Schnetkamp Cation fluxes and cation channels in outer segment membranes of bovine retinal rods: contamination by antibiotics applied to cattle? CONTENTS/SOMMAIRE P. Ponka, D.R. Richardson, J.T. Edward, and F.L. Chubb Iron chelators of the pyridoxal isonicotinoy! hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to mobilise iron from reticulocytes in vitro Christine Forster, George O.A. Naik, and Giulia Larosa Myocardial 8-adrenoceptors in pacing-induced heart failure: regulation by enalapril? W.Q. Long and N.R. Anthonisen Aminophylline partially blocks ventilatory depression with hypoxia in the awake cat Anne B. Gould, Susan Goodman, and Charles Swartz Blood pressure control and erythrocytosis in rats: theory and observations Andrés C. Inglés, Dallas J. Legare, and W. Wayne Lautt Distensibility of protacaval shunts in portal hypertensive cats: index of con- tractility model Sally A. Lang, Michael B. Maron, Frank J. Bosso, and Charles F. Pilati Temporal changes in left ventricular function after massive sympathetic nervous system activation BRIEF REPORTS B.A. Woods, T.M. Myckatyn, and C.A. Courneya Hemorrhage from the inferior vena cava versus the ear artery: a comparison of cardio- vascular and hormonal responses in conscious rabbits Luke J. Janssen and Stephen M. Sims Substance P activates Cl” and K* conductances in guinea-pig tracheal smooth muscle cells JU/LJ UIYLLE T ARTICLES G.S. Hamilton and T.G. Kennedy Uterine vascular permeability after uterine stimulation to rats differentially sensitized for the decidual cell reaction I. Komaromi, T.J. Malkinson, W.L. Veale, G. Rosenbaum, K.E. Cooper, and Q.J. Pittman Effect of potassium-induced cortical spreading depression on prostaglandin-induced fever in conscious and urethane-anesthetized rats Tom L. Broderick, Stephen J. Kopp, June T. Daar, Fred D. Romano, and Dennis J. Paulson Relation of glycosylated hemoglobin to in vivo cardiac function in response to dobutamine in spontaneously diabetic BB Wor rats M.I. Hasham, D. Naumann, S.U. Kim, N.R. Cashman, G.A. Quamme, and C. Krieger Intracellular calcium concentrations during metabolic inhibition in the motoneuron cell line NSC-19 Sean K. O’Neill, Chris R. Triggle, and Gordon T. Bolger Competitive binding experiments reveal differential interactions for dihydro- pyridine calcium channel activators and antagonists at dihydropyridine receptors on mouse brain membranes Jovan Bozinovski, James F. Brien, Gerald S. Marks, and Kanji Nakatsu Inhibition of nitrovasodilators by pyocyanin and methylene blue is dissociated from nitric oxide formation Fiigen Aktan and Serpil Nebioglu Effect of vanadium compounds on calmodulin activity in experimental diabetes in rats Keiichi Shimamura, Masumi Kusaka, and Nicholas Sperelakis Oxytocin induces an inward current in pregnant rat myometrial cells N. Krishnamra, K. Angkanaporn, and T. Deenoi Comparison of calcium absorptive and secretory capacities of segments of intact or function- ally resected intestine during normo-, hypo-, and hyper-calcemia Soter Dai, Mary E. Todd, Stephanie Lee, and John H. McNeill Fructose loading induces cardiovascular and metabolic changes in nondiabetic and diabetic rats L. Fan, S. Mukaddam-Daher, J. Gutkowska, B.S. Nuwayhid, and E.W. Quillen, Jr. Renal perfusion pressure and renin secretion in bilaterally renal denervated sheep Donald E. Roberts, Michael N. Sawka, Andrew J. Young, and Beau J. Freund Pyridostigmine bromide does not alter thermoregulation during exercise in cold air D.O. Ajikobi and W.A. Cupples In vitro response of rat renal artery to perfusion pressure Baiqiang Cai, Qinzhong Hao, Stan S. Greenberg, Bennett deBoisblanc, Doug Gillott, Reza Goharderakhshan, Warren R. Summer, Al Hyman, and Howard Lippton Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neuro- transmission O. Hudlicka, S. Egginton, M.D. Brown, and I. Okyayuz-Baklouti Effect of torbafylline on muscle blood flow, performance, and capillary supply in ischemic muscles subjected to varying levels of activity John M. Kowalchuk and Barry W. Scheuermann Acid—base regulation: a comparison of quantitative methods Catherine J. Field, Guoyao Wu, and Errol B. Marliss_ Enhanced metabolism of glucose and glutamine in mesenteric lymph node lymphocytes from spontaneously diabetic BB rats AuGust/ AOUT ARTICLES Corinne Huchet and Claude Léoty Effect of cyclopiazonic acid on contractile responses in slow and fast bundles of cremaster skeletal muscle from the ferret G. Harvey Anderson, Shugin Luo, Leonidas Trigazis, Greta Kubis, and Edmund T.S. Li Effects of essential amino acids on food and water intake of rats C-6 CAN. J. PHYSIOL. PHARMACOL. VOL. 72, 1994 Daniel Henrion and Ismail Laher _ Insulin potentiates norepinephrine-induced vascular tone by activation of protein kinase C and tyrosine kinase Sylvain Foucart, Rui Wang, Pierre Moreau, Rémi Sauvé, Jacques de Champlain, Nobuharu Yamaguchi, Lin Bai, and Xin-Ran Lu_ Effects of Buthus martensii Karsch scorpion venom on the release of noradrenaline from in vitro and in vivo rat preparations Seigo Fujimoto «,-Adrenoceptor subtypes mediating contraction of the femoral artery in spontaneously hypertensive rats D.J. Crankshaw and R. Dyal Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contractility of the human lower uterine segment in vitro Stéphane St-Onge, Peter Chidiac, Léa Brakier-Gingras, and Michel Bouvier -Adrenergic receptor desensitization in the early stage of hereditary cardiomyopathy in hamsters Alicia M. Passerin and William N. Henley Activation of spinal cord serotonergic neurons accompanies cold-induced sympathoexcitation J.C. Szerb, K. Clow, and D.D. Rasmusson Pharmacological but not physiological modulation of cortical acetylcholine release by cholinergic mechanisms in the nucleus basalis magnocellularis Mary-Ellen Harper and Martin D. Brand Hyperthyroidism stimulates mitochondrial proton leak and ATP turnover in rat hepatocytes but does not change the overall kinetics of substrate oxidation reactions BRIEF REPORT / RAPPORT BREF K. Kong, C. Ukachoke, P. Ashby, and K.R. Chapman Excitability of human motor cortex during hyperventilation and hypercapnia SYMPOSIUM OF THE CANADIAN FEDERATION OF BIOLOGICAL SOCIETIES SYMPOSIUM DE LA FEDERATION CANADIENNE DES SOCIETES DE BIOLOGIE The Relationship Between Diet and Hypertension: From the Cell to the Patient (La relation entre la diéte et ’hypertension : de la cellule au patient) Windsor, Ontario, Canada June 17, 1993 / le 17 juin 1993 C.R. Triggle Introduction: The Relatiolnship Between Diet and Hypertension: From the Cell to the Patient Michael P. Walsh Regulation of vascular smooth muscle tone David A. McCarron, Daniel Hatton, Jean-Baptiste Roullet, and Chantal Roullet Dietary calcium, defective cellular Ca** handling, and arterial pressure control R.M.K.W. Lee Fish oil, essential fatty acids, and hypertension Ernesto L. Schiffrin Intracellular signal transduction for vasoactive peptides in hypertension SEPTEMBER/ SEPTEMBRE ARTICLES Peter Germann, Ismail Laher, Tino Poseno, and John A. Bevan Barbiturate attenuation of agonist affinity in cerebral arteries correlates with anesthetic potency and lipid solubility M. Desautels and R.A. Dulos Hemin inhibits protein synthesis and degradation in isolated brown adipose tissue mitochondria Peter R.H. Wilkes, Robert W. Hoskin, Eric A. Semlacher, Keith L. MacCannell, and John V. Tyberg Reevaluation of the balloon in gastrointestinal manometry Peter Cernacek, Duncan J. Stewart, and Mortimer Levy Plasma endothelin-1 response to acute hypotension induced by vasodilating agents Christine Jean, Denis Roy, and André Nadeau Diminished diabetogenic effect of streptozotocin in adrenodemedullated rats Peter James O’Brien, Gordon W. Moe, Linda M. Nowack, Etienne A. Grima, and Paul W. Armstrong Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs N. Woodley and J.K. Barclay Cultured endothelial cells from distinct vascular areas show differential responses to agonists Ricardo A. Brown, Prashant Bhasin, Adedapo O. Savage, and Joseph C. Dunbar Chronic verapamil treatment attenuates the negative inotropic effect of ethanol in diabetic rat myocardium David O. Ajikobi and William A. Cupples a)>-Adrenergic mediation of the effects of angiotensin II on rat renal artery in vitro Douglas J. Pon, Carlo J. van Staden, Louise Boulet, and Ian W. Rodger Hyperplastic effects of aerosolized sodium metabisulfite on rat airway mucus-secretory epithelial cells Alastair V. Ferguson and Craig Loucks Cardiovascular and single-unit responses to subfornical organ stimulation are abolished by pentobarbital anesthesia J.K. Barclay and N.E. Woodley Nitric oxide synthase inhibitors do not alter functional hyperemia in canine skeletal muscle J. Thornhill, A. Jugnauth, and I. Halvorson Brown adipose tissue thermogenesis evoked by medial preoptic stimulation is mediated via the ventromedial hypothalamic nucleus I. Berezin, E.E. Daniel, and J.D. Huizinga Ultrastructure of interstitial cells of Cajal in the canine distal esophagus Alison M.J. Buchan and R. Mark Meloche Signal transduction events involved in bombesin-stimulated gastrin release from human Gc ells in culture CONTENTS/SOMMAIRE Melvin J. Fregly, Fabian Rossi, and J. Robert Cade Ar ole for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy A.A. Laniyonu, M. Saifeddine, S.-G. Yang, and M.D. Hollenberg Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonists Ismail Laher, Peter Germann, and John A. Bevan Neurogenically evoked cerebral artcvy constriction is mediated by neuropeptide Y BRIEF REPORTS / RAPPORTS BREFS C.L. Murrant, N.E. Woodley, and J.K. Barclay Effect of nitroprusside and endothelium-derived products on slow-twitch skeletal muscle function in vitro J. Van de Voorde, S. Vyt, and B. Vanheel The basal endothelial inhibitory influence on vascular tone is not affected in nitroglycerin-tolerant rat aorta ERRATA D.V. Rayner, Moira E.A. Thomas, and Paul Trayhurn = Erratum: Glucose transporters (GLUTs 1 —4) and their mRNAs in regions of the rat brain: insulin-sensitive transporter expression in the cerebellum Erratum: Abstracts of the XII" International Congress of Pharmacology OCTOBER/OCTOBRE The 1993 Merck Frosst Award / (Le prix Merck Frosst 1993) Gary D. Lopaschuk and Jim Gamble Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart ARTICLES Maruf Saddik and Gary D. Lopaschuk Triacylglycerol turnover in isolated working hearts of acutely diabetic rats Catherine Communal, Jean Verdetti, Colette Estrade, Thierry Humbert, and Pierre Demenge Heterogeneous distribution of a fatty acid analogue uptake in the myocardium of aged rats Gilberto Castafeda-Hernandez, Maria Soledad Castillo-Méndez, Francisco J. Lépez-Muiioz,Vinicio Granados-Soto, and Francisco J. Flores-Murrieta Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat Raouf E. Naguib, Chantal Contant, and W.A. Cupples Atrial natriuretic factor, angiotensin II, and the slow component of renal auto- regulation Claus Schafer, Hanna Steffen, Hartmut Printz, and Burkhard Géke Effects of synthetic cyclic AMP analogs on amylase exocytosis from rat pancreatic acini Giulia Larosa, Paul W. Armstrong, and Christine Forster Endothelium-dependent relaxations in canine coronary arteries are enhanced in early heart failure and persist in recovery Timothy J. Kieffer, Phil J. Schieldrop, Ewen McLean, Edward M. Donaldson, and John C. Brown A radioimmunoassay for oncorhynchid growth hormone targeted to the physiological range Lynda M. Herman, Soter Dai, Neil G. Hartman, and John H. McNeill —meta-lodobenzylguanidine uptake in the hypertensive —diabetic rat heart: a marker for myocardial dysfunction? H. Sonnenberg, U. Honrath, C.K. Chong, L.J. Field, and A.T. Veress Proximal tubular function in transgenic mice overexpressing atrial natriuretic factor Hui Xie and Christopher R. Triggle The endothelium contributes to the contractile responses of the human umbilical artery to 5-hydroxy- tryptamine and endothelin-1 under low but not high Po, conditions Jilin Yang and Stephen C. Cunnane Quantitative measurements of dietary and [1-'*C]linoleate metabolism in pregnant rats: specific influence of moderate zinc depletion independent of food intake P.K. Dinda, M.G. Buell, O. Morris, and I.T. Beck Studies on ethanol-induced subepithelial fluid accumulation and jejunal villus bleb formation. An in vitro video microscopic approach R.D. Kilgour and J. Carvalho Gender differences in cardiovascular responses to the cold hand pressor test and facial cooling Teresa Trippenbach and Norma Lake Excitatory cardiovascular and respiratory effects of baclofen in intact rats Shannon L. Venance, Brian M. Bennett, and Stephen C. Pang __ Isoproterenol exerts cyclic AMP independent effects on DNA synthesis in cultured adventitial fibroblasts from spontaneously hypertensive and Wistar—Kyoto rats X. Jia, J.C. Brown, Y.N. Kwok, R.A. Pederson, and C.H.S. McIntosh Gastric inhibitory polypeptide and glucagon-like peptide-1(7 — 36) amide exert similar effects on somatostatin secretion but opposite effects on gastrin secretion from the rat stomach Murat Oz and George B. Frank Effect of the calcium channel agonist Bay K8644 on mechanical and electrical responses of frog skeletal muscle M. Abelenda, C. Castro, C. Venero, and M. Puerta Reduced oxygen consumption of brown adipocytes isolated from progesterone-treated rats C-8 CAN. J. PHYSIOL. PHARMACOL. VOL. 72, 1994 J. Dossett-Mercer, H.J. Green, E. Chin, and E. Grange Preservation of sarcoplasmic reticulum Ca”*-sequencing function in homogenates of different fibre type composition following sprint activity Adnan A. Elfarra, Renee J. Duescher, Peter J. Sausen, Todd M. O’Hara, and A. James Cooley Methimazole protection of rats against gentamicin-induced nephrotoxicity Fred D. Romano, Stephen J. Kopp, June T. Daar, and Cynthia S. Smith The antiadrenergic effect of cyclopentyladenosine on myocardial contractility is reduced in vivo in diabetic rats Rolando Hernandez-Mufioz and Victoria Chagoya de Sanchez In vivo correlation between liver and blood energy status as evidenced by chronic treatment of carbon tetrachloride and adenosine to rats ERRATUM Michael P. Walsh Erratum: Regulation cf vascular smooth muscle tone NOVEMBER/ NOVEMBRE ARTICLES Limin Liu and David L. Severson Regulation of myocardial lipoprotein lipase activity by diabetes and thyroid hormones Enrique J. Sanchez Pozzi, Viviana A. Catania, Marcelo G. Luquita, Marcelo G. Roma, Emilio A. Rodriquez Garay, and Aldo D. Mottino Effect of oral administration or ursodeoxycholic acid on rat hepatic and intestinal UDP-glucuronosyltransferase M. Mehran, E. Seidman, C. Gurbindo, and E. Levy Lipid esterification and synthesis by the IEC-6 intestinal epithelial crypt cell line: effect of transforming growth factor 6 Menashe B. Waxman, John A. Asta, and Douglas A. Cameron Paradoxic bradycardia (vasodepressor reaction) induced by inferior vena cava occlusion: the role of a- and B-adrenergic receptors and their interaction Soter Dai, Heather Fraser, Violet G. Yuen, and John H. McNeill Improvement in cardiac function in streptozotocin-diabetic rats by salt loading Immaculada Montanés, Olga Flores, Nélida Eleno, and José M. Lépez-Novoa Effects of a new dihydropyridine derivative, $12968 (pranedipine), and its stereoisomer, $12967, on renal effects of endothelin-1 Palmira Zubin and Cristina Defagot Effect of ovarian steroids on hypothalamic norepinephrine-induced adenylate cyclase activity Keiichi Shimamura, Masumi Kusaka, and Nicholas Sperelakis Protein kinase C stimulates Ca** current in pregnant rat myometrial cells RAPID COMMUNICATION / COMMUNICATION RAPIDE B.L. Tepperman and B.D. Soper Nitric oxide synthase induction and cytoprotection of rat gastric mucosa from injury by ethanol Smooth Muscle Contraction: Recent Advances (Contraction du lisse : les récents développements) Minaki, Ontario, Canada August 23—27, 1993 / le 23—27 aout 1993 INTRODUCTION Newman L. Stephens Smooth Muscle Contractions: Recent Advances ARTICLES Lincoln E. Ford, Chun Y. Seow, and Victor R. Pratusevich Plasticity in smooth muscle, a hypothesis Richard A. Meiss Transient length-related mechanical states in smooth muscle Per Hellstrand Cross-bridge kinetics and shortening in smooth muscle Ulrich Peiper and Jiirgen Dee Smooth muscle contraction kinetics at different calcium concentrations N.L. Stephens and H. Jiang Relaxation of smooth muscle Christine A. Kelley and Robert S. Adelstein Characterization of isoform diversity in smooth muscle myosin heavy chains W. Glenn L. Kerrick and Phyllis E. Hoar Relationship between ATPase activity, Ca?*, and force in a-toxin- and 8-escin-treated smooth muscle Apolinary Sobieszek Regulation of myosin light chain kinase: kinetic mechanism, autophosphorylation, and cooperative activation by Ca?* and calmodulin Setsuro Ebashi and Hideto Kuwayama Is phosphorylation the main physiological action of myosin light chain kinase? Nancy L. McDaniel, Christopher M. Rembold, and Richard A. Murphy Cyclic nucleotide dependent relaxation in vascular smooth muscle Yawen Zhang, Suzanne Moreland, and Robert S. Moreland Regulation of vascular smooth muscle contraction: myosin light chain phos- phorylation dependent and independent pathways CONTENTS/SOMMAIRE Michael P. Walsh, Jacquelyn E. Andrea, Bruce G. Allen, Odile Clément-Chomienne, Elizabeth M. Collins, and Kathleen G. Morgan Smooth muscle protein kinase C! Joe R. Haeberle and Mark E. Hemric A model for the coregulation of smooth muscle actomyosin by caldesmon, calponin, tropomyosin, and the myosin regulatory light chain William T. Gerthoffer and Jennifer Pohl Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction Jeffrey D. Carmichael, Steven J. Winder, Michael P. Walsh, and Gary J. Kargacin Calponin and smooth muscle regulation Anik6é Rokolya, Hee Yul Ahn, Suzanne Moreland, Cornelis van Breemen, and Robert S. Moreland Ah ypothesis for the mechanism of receptor and G-protein-dependent enhancement of vascular smooth muscle myofilament Ca?* sensitivity M.D. Pato, A.G. Tulloch, M.P. Walsh, and E. Kerc Smooth muscle phosphatases: structure, regulation, and function Joseph Di Salvo, Gabrielle Pfitzer, and Lori A. Semenchuk Protein tyrosine phosphorylation, cellular Ca2*, and Ca?* sensitivity for con- traction of smooth muscle He Jiang, Kang Rao, Xueliang Liu, Andrew J. Halayko, Gang Liu, and Newman L. Stephens Early changes in airway smooth muscle hyperresponsiveness Andrew J. Halayko and Newman L. Stephens Potential role for phenotypic modulation of bronchial smooth muscle cells in chronic asthma Weilong Li and Newman L. Stephens Auxotonic loading and airway smooth muscle shortening J. Belik Large pulmonary arteries and the control of pulmonary vascular resistance in the newborn Suzanne Moreland Endothelin receptor antagonists: a brief review DECEMBER/DECEMBRE The 1993 Upjohn Award Lecture / (La Conférence Upjohn 1993) K.H. Jhamandas, R.J. Boegman, and R.J. Beninger Quinolinic acid induced brain neurotransmitter deficits: modulation by endogenous excitotoxin antagonists The 1993 Borden Award Lecture / (La Conférence Borden 1993) Sheila M. Innis Fatty acid requirements of the newborn The 1994 Merck Frosst Award / (Le prix Merck Frosst 1994) John L. Wallace Mechanisms of nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal damage—potential for development of gastrointestinal tract safe NSAIDs Critical Review / Synthese critique Donald B. Jennings The physicochemistry of [H*] and respiratory control: roles of Pco>, strong ions, and their hormonal regulators ARTICLES Bernard J. McDonald, Greg J. Monkewich, Patrick G. Long, Diane J. Anderson, Paul E. Thomas, and Brian M. Bennett Effect of dexamethasone treatment on the biotransformation of glyceryl trinitrate: cytochrome P450 3A1 mediated activation of rat aortic guanylyl cyclase by glyceryl trinitrate K. Krishnamra and V. Cheeveewattana Studies of acute effect of prolactin on distribution of absorbed calcium and long-term effect on calcium balance in weaned, young, and sexually mature rats Deborah J. Clark and James E. Fewell Body-core temperature decreases during hypoxic hypoxia in Long—Evans and Brattleboro rats R. Soulimani, C. Younos, F. Mortier, and C. Derrieu The role of stomachal digestion on the pharmacological activity of plant extracts, using as an example extracts of Harpagophytum procumbens Heyi Liu and John H. McNeill Effects of vanadium treatment on the alterations of cardiac glycogen phosphorylase and phosphorylase kinase in streptozotocin-induced chronic diabetic rats Worku Abebe, Kim Howard Harris, and Kathleen M. MacLeod Role of extracellular Ca** in the selective enhancement of contractile responses of arteries from diabetic rats to noradrenaline Susan J. Hemmings and Kenneth B. Storey Alterations in hepatic adrenergic receptor status in Rana sylvatica in response to freezing and thawing: implications to the freeze-induced glycemic response A.T. Veress, C.K. Chong, U. Honrath, and H. Sonnenberg Effect of bradykinin B, receptor antagonist and indomethacin on natriuretic and hypotensive responses to atrial natriuretic factor Tristram P.D. Eldershaw, Stephen Rattigan, Kim A. Dora, Eric Q. Colquhoun, Michael G. Clark, Michael A. Cawthorne, and Robin E. Buckingham Potential defect in the vascular control of nonshivering thermogenesis in the obese Zucker rat hind limb Anthony P. Williamson, Ernst Seifen, Jon P. Lindemann, and Richard H. Kennedy «-Adrenergic receptor mediated positive chrono- tropic effect in right atria isolated from rats M.C. Garcia and J. Escamilla-Sanchez Positive inotropic effect of adrenaline on potassium contractures in tonic skeletal muscle fibres of the frog C-10 CAN. J. PHYSIOL. PHARMACOL. VOL. 72, 1994 BRIEF REPORT / RAPPORT BREF Hidenari Sakuta Inhibition by antidepressants of glibenclamide-sensitive K* currents in follicle-enclosed Xenopus oocytes Note of appreciation / Note de reconnaissance Author index for Volume 72 / Index des auteurs pour le volume 72 Subject index for Volume 72 / Index des matiéres pour le volume 72 Contents for Volume 72 / Sommaire pour le volume 72