Calcified Tissues 1965: Proceedings of the Third European Symposium on Calcified Tissues held at Davos (Switzerland), April 11th–16th, 1965 PDF
Preview Calcified Tissues 1965: Proceedings of the Third European Symposium on Calcified Tissues held at Davos (Switzerland), April 11th–16th, 1965
Calcified Tissues 1965 Calcified Tissues 1965 Proceedings of the Third European Symposium on Calcified Tissues held at Davos (Switzerland), April 11th-16th, 1965 Sponsored by the Laboratorium fUr experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos Edited by ].J. H. FLEISCH, H. BLACKWOOD and M. OWEN with the assistance of M. P. FLEISCH-RoNCHETTI SPRINGER-VERLAG· NEW YORK' INC. 1966 ISBN 978-3-642-85843-7 ISBN 978-3-642-85841-3 (eBook) DOl 10.1007/978-3-642-85841-3 All rights, especially that of translation into foreign languages, reserved. It is also forbidden to reproduce this book, either whole or in part, by photomechanical means (photostat, microfilm andlor microcard) or by other procedure without written permission from Springer-Verlag. © by Springer-Verlag Berl>n . HeIdelberg 1966 Softcover reprint of the hardcover 1 st echtton 1966 LIbrary of Congress Catalog Card Number 65-27964 Titelnummer 1323 Preface The papers collected in this volume represent the formal proceedings of the Third European Symposium on Calcified Tissues which was held in Davos, Switzerland from 11th to 16th April 1965 under the sponsorship of the Laboratorium fur experi mentelle Chirurgie, Schweizerisches Forschungsinstitut Davos. This Symposium fol lowed the now established tradition of the previous Symposia held in Oxford in 1963 and in Liege in 1964. Participation was again strictly on a residential basis. This year the Schatz alp Hotel provided a scenic and secluded meeting place high on a mountain side overlooking Davos yet close to the Forschungsinstitut in which the opening session of the Symposium was held. The papers and communications published in the volume are arranged in order of presentation and are grouped under the five main themes selected for discussion by the Symposium, namely, "Cell function in the formation, maintenance and destruc tion of osseous tissue", "Response of calcified tissues to mechanical factors", "Mecha nisms of mineralization and diseases related to mineral deposition", "Hormones and bone" and "Fundamental structure of dental hard tissues". The programme consisted of a number of review lectures given by invited speakers and of short communications in relation to each of the above themes. No attempt was made to record the dis cussions to the papers as, being a residential meeting, the more valuable and interest ing interchanges took place informally in small discussion groups and not within the time schedule of the prearranged programme. The Committees wish to express their thanks to the staff of the Laboratory for Experimental Surgery, Davos for their most valuable help and to all of the following who made this meeting possible through their financial support: Zentralverband schweizerischer Milchproduzenten; Nestle Alimentana S.A., Cham et Vevey; Sandoz AG., Basel; Robapharm AG., Basel; Ciba AG., Basel; J. R. Geigy AG., Basel; F. Hoff mann-La Roche & Co. AG., Basel; Dr. A. Wander AG., Bern; Emser Werke AG., Domat/Ems; Laboratorien Hausmann AG., St. Gallen; Davos-Parsenn-Bahnen AG., Davos; Kleiner Rat des Kantons Graubunden; Landschaft Davos; Migros-Genossen schafts-Bund, Zurich; Schweizerische U nfall versicherungs-Gesellschaft, Winterthur; Treupha AG., Baden; Siegfried AG., Zofingen; Verkehrsverein Davos. The European Symposium on Calcified Tissues is held annually and Professor P. GAILLARD'S invitation on behalf of the University of Leiden to meet in Holland in 1966 has been warmly accepted. The editorial committee: The organizing committee: H. J. J. BLACKWOOD C. A. BAUD H. G. HAAS H. FLEISCH M. J. DALLEMAGNE L. RICHELLE M.OWEN H. FLEISCH R. SCHENK Contents Session I Cell Function in the Formation, Maintenance and Destruction of Osseous Tissue Chairmen: P. GAILLARD, I. MAcINTYRE, H. J. DULCE, A. B. BORLE L. F. BELANGER, T. SEMBA, S. TOLNAI, D. H. COPP, L. KROOK and C. GRIES The Two Faces of Resorption . . .. ......... . W. A. DE VOOGD VAN DER STRAATEN Some Remarks and Questions on Metabolic Patterns in the Family of Bone Cells. 10 CH. M. LAPIERE Remodelling of the Bone Matrix . . 20 M. E. HOLTROP The Origin of Bone Cells in EndodlOndral Ossification . 32 M. OWEN RNA Synthesis in Growing Bone . . . . 36 ]. S. GREENSPAN and H. ]. J. BLACKWOOD Histochemical Studies of Chondrocyte Function in the Cartilage of the Mandibular Condyle of the Rat . . . . . . . . . 40 A. B. BORLE Correlation between Morphological, Biochemical, and Biophysical Effects of Para- thyroid Hormone on Cell Membranes 45 P. A. THORNTON Vitamin D-ascorbic Acid Association in Bone Metabolism 48 C. B. SLEDGE Lysosomes and Cartilage Resorption in Organ Culture. . . . . . . . . 52 G. VAES Acid Hydrolases, Lysosomes and Bone Resorption Induced by Parathyroid Hormone 56 A. DHEM Le forage des canaux de Havers. . . . 60 E. RUTISHAUSER, W. TAILLARD and B. FRIEDLI Experimental Studies of the Non-inflammatory Vascular Pannus 63 L. V. A vrOLi and PH. H. HENNEMAN Urinary Pyrophosphate in Disorders of Bone Metabolism 67 ]. ]OWSEY Bone Formation and Resorption in Bone Disorders . . . . . . . . 69 J. C. BIRKENHAGER, J. VAN DER SLUYS VEER, R. O. VAN DER HEUL and D. SMEENK Studies of Iliac Crest Bone from Controls and Patients with Bone Disease by Means of Chemical Analysis, Tetracycline Labelling and Histology. . . . . . 73 VIII Contents Session II Response of Calcified Tissues to Mechanical Factors Chairman: R. AMPRINO C. A. L. BASSETT Electro-mechanical Factors Regulating Bone Architecture 78 G. MAROTTI and F. MAROTTI Topographic-quantitative Study of Bone Tissue Formation and Reconstruction in Inert Bones . . . . • . . . . . . . . . . . . . . . . . . . . . 89 H. WAGNER Structure and Healing of Bone as a Response to Continuous and Discontinuous Strain and Stress. . . • . . . . . . . . . . . . . . . . . . . 93 E. D. SEDLIN and L. SONNERUP Rheological Considerations in the Physical Properties of Bone 98 M. BROOKES Haemodynamic Data on the Osseous Circulation. . . 101 N. E. SHAW The Influence of Muscle Blood-flow on the Circulation in Bones 104 Session III Mechanisms of Mineralization and Diseases Related to Mineral Deposition Chairmen: S. M. PARTRIDGE, B. ENGFELDT, W. D. ARMSTRONG, J. P. AUBERT and H. C. G. BAUER F. G. E. PAUTARD A Biomolecular Survey of Calcification 108 L. J. RICHELLE, C. ONKELINX and J.-P. AUBERT Bone Mineral Metabolism in the Rat. . 123 P. LERCH and C. VUILLEUMIER Physico-chemical Methods for the Identification of Microcrystalline Basic Calcium Phosphates Prepared in Vitro . . . . . 132 H. NEWESELY Umwandlungsvorgange bei Calciumphosphaten 136 J. MACGREGOR Some Observations on the Nature of Bone Mineral 138 A. ASCENZI and E. BONUCCI The Osteon Calcification as Revealed by the Electron Microscope 142 H. J. HOHLING, H. THEMANN and J. V AHL Collagen and Apatite in Hard Tissues and Pathological Formations from a Crystal Chemical Point of View. ............ . 146 H.J.ARNOTT Studies of Calcification in Plants . . . . . . . . 152 R. LAGIER, C. A. BAUD and M. BUCHS Crystallographic Identification of Calcium Deposits as Regards to their Pathological Nature, with Special Reference to Chondrocalcinosis 158 A. POLICARD, C. A. BAUD, A. COLLET, H. DANIEL-MoUSSARD and J. C. MARTIN Infrastructural and Crystallographic Study of Experimental Calcifications . 162 S. M. KRANE and M. J. GLIMCHER Protein Phosphorus and Phosphokinases in Connective Tissue . . . . . . . . . 168 Contents IX W. M. McKERNAN and S. D. DAILL Y The Relationship between Swelling of Hard Tissue Collagen in Acid and Alkali and the Presence of Phosphate Cross-links . . . . . . . . . . . . . . . . 171 R. STEENDIJK, J. JOWSEY, A. VAN DEN HooFF and H. K. 1. NIELSEN Microradiographic and Histological Observations in Primary Vitamin D-resistant Rickets . . . . . . .. ............... . 175 D. B. MORGAN, C. R. PATERSON, C. G. WOODS, C. N. PULVEitTAFT and P. FOURMAN Therapeutic Response and Effect on the Kidney of 100 Units Vitamin D Daily in Osteomalacia after Gastrectomy ................ . 178 T. G. TAYLOR, A. WILLIAMS and J. KIRKLEY Changes in the Activities of Plasma Acid and Alkaline Phosphatases during Egg Shell Calcification in the Domestic Fowl . . . . . . . . 182 J. C. STOCLET and Y. COHEN Calcium Exchanges in the Aorta of the Rat 186 G. D. MCPHERSON Estimation of the 24 Hour Exchangeable Calcium Pool in Children Using 4BCa 189 1. MIRA VET et D. HIOCO Transfert du calcium intestinal chez l'homme dans les maladies demineralisantes de l'os 193 1. LUTWAK Absorption of Calcium in Man: Effect of Disease, Hormones and Vitamin D . .. 198 J.-F. DYMLING Therapeutic Results in Renal Tubular Osteomalacia with Special Reference to Calcium Kinetics .......................... 202 G. MILHAUD et J. BOURICHON Etude du metabolisme du calcium chez l'homme a l'aide de calcium 45: l'osteopetrose et l'osteopsathyrose. . • . • • . . . . . . . . . . . . . . . . . . 207 D. A. SMITH and C. J. MACKENZIE Calcium Clearance and Re-absorption in Patients with Osteoporosis, Renal Stone and Primary Hyperparathyroidism . . . . . . . . . . . . . . 211 Session IV Hormones and Bone Chairmen: P. FOURMAN and P. H. HENNEMAN G. NICHOLS, JR. Bony Targets of Non-"skeletal" Hormones 215 B. E. C. NORDIN Hormones and Calcium Metabolism . . . . . . . . . . . 226 H. A. SOLIMAN, C. J. ROBINSON, G. V. FOSTER and I. MAcINTYRE Mode of Action of Calcitonin . . . . . . . . . . . . . 242 E. UEHLINGER Of the Influence of Thyroxine, Thiouracil, Cortisone, Estrogen and Testosterone on Endo- chondral Ossification Utilizing Autoradiography. . . . . . . . . .. 243 J. A. FERNANDEZ DE VALDERRAMA and 1. M. MUNUERA The Effect of Cortisone and Anabolic Agents on Bone. 245 W. M. RIGAL and W. M. HUNTER Sites and Mode of Action of Growth Hormone . . . 250 G. F. MAZZUOLI and 1. TERRENATO Intestinal Absorption and Skeletal Dynamic of Calcium in Acromegaly 254 x Contents Session V Fundamental Structure of Hard Dental Tissues Chairman: H. J. J. BLACKWOOD R. M. FRANK Ultrastructure of Human Dentin 259 E. P. KATZ, G. MECHANIC and M. J. GLIMCHER Preliminary Studies of the Ultracentrifugal and Free Zone Electrophoresis Charac teristics of Neutral Soluble Proteins of Bovine Embryo Enamel. . . . . . 272 A. BOYDE The Development of Enamel Structure in Mammals . 276 List of participants Allgower, M., Kantonsspital, Chur, Schweiz. Amprino, R., Istituto di Anatomia Umana, Universidt, Bari, Italia. Armstrong, W. D., Department of Physiological Chemistry, University of Minnesota, Min- neapolis, Minn., USA. Arnott, H. J., Cell Biology Institute, University of Texas, Austin, Texas, USA. Ascenzi, A., Istituto di Anatomia Patologica, Universidl, Pisa, Italia. Aubert, J.-P., Institut Pasteur, Paris, France. Avioli, L. V., Seton Hall College, Division of Endrocrinology, Jersey City, N. J., USA. Bachra, B. N., Laboratory of Physiological Chemistry, Leiden, Holland. Bassett, C. A. L., Department of Research Orthopaedics, Columbia University, College of Physicians and Surgeons, New York, N. Y., USA. Baud, C. A., Institut de Morphologie, Ecole de Mcdecine, Geneve, Suisse. Bauer, G. C. H., Hospital for Special Surgery, New York, N. Y., USA. Belanger, L. F., Department of Histology, University of Ottawa, Ottawa, Canada. Bengtsson, A., Department of Pathology, University, Uppsala, Sweden. Bersin, T., Laboratorium Hausmann AG., St. Gallen, Schweiz. Birkenhager, J. c., Department for Diseases of Metabolism, University Hospital, Leidcn, Nederland. Birkenhager-Frenkel, D. H., Antoni van Leeuwenhoekhuis, Amsterdam, Nederland. Bisaz, S., Laboratorium fiir experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Dav os, Schweiz. Blackwood, H. J. J., Royal Dental Hospital, School of Dental Surgery, London, England. Bohr, H., Orthopaedic Hospital, Copenhagen, Denmark. Bolognani, L., Istituto di Chimica Biologica, Universita, Pavia, Italia. Bonucci, E., Istituto di Anatomia Patologica, Universita, Pisa, Italia. Bordier, P., Centre du Metabolisme Phosphocalcique, H6pital Lariboisiere, Paris, France. Borle, A. B., Department of Physiology, University of Pittsburgh, Pittsburgh, Pa., USA. Boyde, A., Department of Anatomy, London Hospital Medical College, London, England. Brookes, M., Department of Anatomy, Guy's Hospital Medical School, London, England. Chalmers, J., Orthopaedic Department, Royal Infirmary, Edinburgh, Scotland. Cimasoni, G., Institut Dentaire, Geneve, Suisse. Collet, A., Cerchar B. P. 27, Creil (Oise), France. Coutelier, L., Laboratoire de Chirurgie Orthopcdique et Traumatologie, Louvain, Belgique. Czitober, H., 1. Medizinische Universitatsklinik, Wien, Osterreich. Dallemagne, M. J., Institut de Therapeutique Experimentale, Liege, Belgique. Dhem, A., Laboratoire de Chirurgie Orthopedique et Traumatologie, Louvain, Belgique. Dingle, J. T., Strangeways Research Laboratory, Cambridge, England. Dulce, H. J., Institut fUr angewandte physiologische Chemie und klinische Chemie, Berlin, Deutschland. XII List of participants Dupont, D., Institut de Morphologie, Ecole de Medecine, Geneve, Suisse. Dymling, ]. F., Malmo General Hospital, Malmo, Sweden. Engfeldt, B., Department of Pathology II, University, Uppsala, Sweden. Ezra-Cohn, H., Nuffield Orthopaedic Centre, Oxford, England. Fitton Jackson, S., Strangeways Research Laboratory, Cambridge, England. Fleisch, H., Laboratorium fur experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Schweiz. Foster, G. V., Postgraduate Medical School, London, England. Fourman, P., The School of Medicine, Leeds, England. Frans:ois, P., Institut de Therapeutique Experimentale, Liege, Belgique. Frank, R. M., Institut Dentaire, Faculte de Medecine, Strasbourg, France. Gaillard, P., Laboratorium voor Cytologic en Experimentelc Histologie, Universiteit, Leiden, Nederland. Greenspan, ]. S., Royal Dental Hospital, School of Dental Surgery, London, England. Haas, H. G., Medizinische Universit:itsklinik, Burgerspital, Basel, Schweiz. Hartles, R. L., School of Dental Surgery, University, Liverpool, England. Hattyasy, D., Leninkorut 66, Szeged, Hungary. Hekkelman, ]. W., Laboratorium voor Cytologie en Experimentele Histologie, Universiteit, Leiden, Nederland. Henneman, Ph. H., Seton Hall College, Division of Endocrinology, Jersey City, N. ]., USA. Hess, R., Ciba AG., Basel, Schweiz. Heuck, F., Katharinenhospital, Stuttgart, Deutschland. Hioco, D., Centre du Metabolisme Phosphocalcique, H6pital Lariboisiere, Paris, France. Hohling, H. ]., Institut fur medizinische Physik, Munster, Deutschland. Holtrop, M. E., Laboratorium voor Cytologie en Experimentele Histologie, Universiteit, Leiden, Nederland. Horn, H. D., Urologisch-Balneologische Forschungsstelle, Bad Wildungen, Deutschland. Hooff, A. van den, Jan Swammerdan Instituut, Amsterdam, Nederland. Huggler, A., Kantonsspital, Chur, Schweiz. Jasinski, B., Robapharm AG., Basel, Schweiz. Jasinski, W. K., Institute of Oncology, Warsaw, Poland. Jeffree, G. M., Pathology Research Laboratory, University, Bristol, England. Johnson, N. W., Dental Research Unit, Bristol, England. Jowsey,]., Mayo Clinic, Rochester, Minn., USA. Knese, K. H., Institut fur Biologie, Landw. Hochschule Hohenheim, Stuttgart-Hohenheim, Deutschland. Koskinen, E. V. S., Clinic for Orthopaedics and Traumatology, University, Helsinki, Finland. Krane, S. M., Massachusetts General Hospital, Boston, Mass., USA. Kshirsagar, S. G., M.R.C. Bone-seeking Isotopes Research Unit, Churchill Hospital, Oxford, England. Kuhlencordt, F., Stoffwechsellaboratorium, 1. Medizinische Universitatsklinik, Hamburg Eppendorf, Deutschland. Lagier, R., Institut Universitaire de Pathologie, H6pital Cantonal, Geneve, Suisse. Lapiere, Ch. M., Institut de Medecine, Departement de Clinique et de Pathologie Mcdicales, Universite, Liege, Belgique. Lemaire, R., Clinique Chirurgicale, Universite, Liege, Belgique. Lentner, c., J. R. Geigy AG., Basel, Schweiz. Lerch, P., Institut de Radiophysique Appliquee, Lausanne, Suisse.
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