Table Of Content

VOLUME 83 - CONTENTS No 1 JANUARY 1999 Page Editorials 1 “New” surgical treatments for glaucoma PT Khaw, D Siriwardena 3 Progress in diabetic maculopathy Tom Barrie Commentary Ophthalmic medical assistants SK Webber, M N Jeffrey Newsdesk Original articles CLINICAL SCIENCE Deep sclerectomy with collagen implant: medium term results Marc E Karlen, Enrique Sanchez, Corinne C Schnyder, Michel Sickenberg, André Mermoud Vitrectomy for cystoid macular oedema with attached posterior hyaloid membrane in patients with diabetes Tomohiro Ikeda, Keiko Sato, Takuya Katano, Yasuhito Hayashi Mid-peripheral pattern electrical retinal responses in normals, glaucoma suspects, and glaucoma patients Neal H Shorstein, William W Dawson, Mark B Sherwood Retrospective analysis of risk factors for late presentation of chronic glaucoma Scort Fraser, Catey Bunce, Richard Wormald Immediate intraocular pressure response to selective laser trabeculoplasty Paolo Lanzetta, Ugo Menchini, Gianni Virgili Effect of acute intraocular pressure changes on short posterior ciliary artery haemodynamics Karen M Joos, Matthew D Kay, L E Pillunat, Alon Harris, E Kym Gendron, W ¥ Feuer, Brett E Steinwand High incidence of glucose intolerance in Vogt-Koyanagi—Harada disease Nobuyo Yawata, Satoshi Nakamura, Masaya Kijima, Nakako Ikai, Mitsuyo Kanai, Miyuki Sugita, Shigeaki Ohno Preretinopic changes in the colour vision of juvenile diabetics Anne Kurtenbach, Ulrich Schiefer, Andreas Neu, Eberhart Zrenner Cystoid macular oedema and cytomegalovirus retinitis in patients with HIV disease treated with highly active antiretroviral therapy Nathalie Cassoux, Livia Lumbroso, Bahram Bodaghi, Lydie Zazoun, Christine Katlama, Phuc LeHoang Arterial blood flow characteristics in central retinal vein occlusion and effects of panretinal photocoagulation treatment: an investigation by colour Doppler imaging Avni Murat Avunduk, Hasan Ding, Zerrin Kapicwéglu, Saban Ugurlu, Volkan Dayan, Ercan Korkmaz Quantitative assessment of macular thickness in normal subjects and patients with diabetic retinopathy by scanning retinal thickness analyser Yusuke Oshima, Kazuyuki Emi, Shigeki Yamanishi, Masanobu Motokura The need for cataract surgery: projections based on lens opacity, visual acuity, and personal concern Cathy A McCarty, fill E Keeffe, Hugh R Taylor Measuring the effectiveness of cataract surgery: the reliability and validity of a visual function outcomes instrument D ¥ Lawrence,C Brogan, L Benjamin, D Pickard, S Stewart-Brown Results of small incision extracapsular cataract surgery using the anterior chamber maintainer without viscoelastic Mark Wright, Hector Chawla, Alistair Adams Orbital lymphangioma: an analysis of 26 patients Murat Tung, Ehsan Sadri, Devron H Char A single technique to correct various degrees of upper lid retraction in patients with Graves’ orbitopathy Maarten Ph Mourits, Inna Vladimirovna Sasim Long term results after surgical basal cell carcinoma excision in the eyelid region Stefan Pieh, Andreas Kuchar, Philipp Novak, Rainer Kunstfeld, Gunda Nagel, F ¥ Steinkogler Diseases associated with ocular surface abnormalities: the importance of reflex tearing Kazuo Tsubota, Minako Kaido, Yukiko Yagi, Tsutomu Fujihara, Shigeto Shimmura Reflective meniscometry: a non-invasive method to measure tear meniscus curvature Northiko Yokoi, Anthony Bron, John Tiffany, Nicholas Brown, James Hsuan, Colin Fowler Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases Murat Tunc, Devron H Char, Brooks Crawford, Theodore Miller Peribulbar anaesthesia during keratoplasty: a prospective study of 100 cases Marc Muraine, Emile Calenda, Laure Watt, Nicole Proust, Annie Cardon, Laurent Eupherte, Gerard Brasseur LABORATORY SCIENCE c-myc, p53, and Bel-2 expression and clinical outcome in uveal melanoma 7S Chana, G D Wilson, I A Cree, RA Alexander, N Myatt, M Neale, A ¥ E Foss, ¥ L Hungerford Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial dystrophy (CHED) and autosomal dominant CHED are genetically distinct Maire Callaghan, Collette K Hand, Susan M Kennedy, ¥S usan FitzSimon, Louis M T Collum, Nollaig A Parfrey Perspective Management of inherited outer retinal dystrophies: present and future N H Victor Chong, Alan C Bird Letters to the editor Correspondence Obituary Notices Instructions for authors No 2 FEBRUARY 1999 Page Editorials 131 The “thin man” phenomenon: imperfect filling in of visual space Neil R Miller 132 The healing optic nerve in glaucoma: transforming growth factor f and optic nerve head remodelling M F Cordeiro, P T Khaw Commentary Distribution of azithromycin for the treatment of trachoma Kathryn I Taylor, Hugh R Taylor Newsdesk Original articles CLINICAL SCIENCE The “thin man” phenomenon: a sign of cortical plasticity following inferior homonymous paracentral scotomas Avinoam B Safran, Olivier Achard, Florence Duret, Theodor Landis Ophthalmological follow up of preterm infants: a population based, prospective study of visual acuity and strabismus G Holmstrim, M el Azazi, U Kugelberg Filtration procedures supplemented with mitomycin C in the management of childhood glaucoma Augusto Azuara-Blanco, Richard P Wilson, George L Spaeth, Courtland M Schmidt, James ¥ Augsburger Screening for refractive errors in children: accuracy of the hand held refractor Retinomax to screen for astigmatism Monique Cordonnier, Michéle Dramaix Effect of isosorbide mononitrate on the human optic nerve and choroidal circulations Juan E Grunwald, Alessandro lannaccone, Joan DuPont Indocyanine green guided laser photocoagulation in patients with occult choroidal neovascularisation Andreas W A Weinberger, Hildegard Knabben, Uta Solbach, Sebastian Wolf Infectious keratitis in leprosy Deepa John, Ebenezer Daniel Conjunctival squamous cell carcinoma in Tanzania TR G Poole Efficacy of nedocromil 2% versus fluorometholone 0.1%: a randomised, double masked trial comparing the effects on severe vernal keratoconjunctivitis Khalid F Tabbara, Soliman A Al-Kharashi Confocal microscopy in cornea guttata and Fuchs’ endothelial dystrophy Auguste G-Y Chiou, Stephen C Kaufman, Roger W Beuerman, Toshihiko Ohta, Hisham Soliman, Herbert E Kaufman Cone and rod dysfunction in the NARP syndrome Jtay Chowers, Tally Lerman-Sagie, Orly N Elpeleg, Avraham Shaag, Saul Merin Ring melanoma—a rare cause of refractory glaucoma Vickie Lee, lan A Cree, John L Hungerford Temporal contrast sensitivity with peripheral and central stimulation in glaucoma diagnosis Jsabel M Véelten, Matthias Korth, Folkert K Horn, Wido M Budde Comparison of inferior oblique muscle weakening by anterior transposition or myectomy: a prospective study of 20 cases Byung-Moo Min, Fu-Hee Park, Seung- Young Kim, Seong-Bok Lee LABORATORY SCIENCE Transforming growth factor $B isoforms in human optic nerve heads Janethe D O Pena, Andrew W Taylor, Cynthia S Ricard, Ivonne Vidal, M Rosario Hernandez Long term ultrastructural changes in human corneas after tattooing with non-metallic substances Walter Sekundo, Peter Seifert, Berthold Seitz, Karin U Loeffler Differential induction of proto-oncogene expression and cell death in ocular tissues following ultraviolet irradia- tion of the rateye Hannes Wickert, Kurt Zaar, Andreas Grauer, Markus John, Manfred Zimmermann, Frank Gillardon Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina Richard M Andrews, Philip G Griffiths, Margaret A Johnson, Douglass M Turnbull Human retina contains polyamine sensitive ['H]-ifenprodil binding sites: implications for neuroprotection? N A Sharif, S X Xu Perspective Birdshot retinochoroidopathy Alice T Gasch, Janine A Smith, Scott M Whitcup Letter to the editor Correspondence Book reviews Notices Correction Instructions for authors No 3 MARCH 1999 Page Editorials 257 Diabetic tractional papillopathy: a new (and true) nosological entity? David McLeod 258 Paediatric pseudophakia—choosing the implant power James D H Young 260 Newsdesk Original articles CLINICAL SCIENCE Vitreopapillary traction in proliferative diabetic vitreoretinopathy Peter Kroll, Wolfgang Wiegand, Joerg Schmidt Intraocular lenses in children: changes in axial length, corneal curvature, and refraction D I Flitcroft, D Knight-Nanan, R Bowell, B Lanigan, M O’Keefe Presumed ocular bartonellosis F T Kerkhoff, ¥M Ossewaarde, W S de Loos, A Rothova Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope Noemi Lois, Anthony S Halfyard, Catey Bunce, Alan C Bird, Fredrick W Fitzke Age over 46 years does not affect the pressure lowering effect of trabeculectomy in primary open angle glaucoma M C Briggs, JL Jay Follow up of focal narrowing of retinal arterioles in glaucoma Konstantinos I PapastathopoulosFo,s t B Jonas Detection of optic disc change with the Heidelberg retina tomograph before confirmed visual field change in ocular hypertensives converting to early glaucoma DS Kamal, A C Viswanathan, D F Garway-Heath, RA Hitchings, D Poinoosawmy, C Bunce Comparison between laser scanning tomography and computerised image analysis of the optic disc Augusto Azuara-Blanco, George L Spaeth, Jamie Nicholl, Ines M Lanzl, James ¥ Augsburger Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc Christian Y Mardin, Folkert K Horn, Jost B Jonas, Wido M Budde Course of exfoliation and simplex glaucoma after primary trabeculectomy Vadislav Popovic, Johan Sjéstrand “Cyclodiode”: results of a standard protocol Anne Fiona Spencer, Stephen A Vernon Prognosis of primary ab externo surgery for primary congenital glaucoma Thomas S Dietlein, Philipp C Facobi, Giinter K Krieglstein The eye in epidermolysis bullosa L Tong, P R Hodgkins, ¥D enyer, D Brosnahan, }H arper, I Russell-Eggitt, D SI Taylor, D Atherton A new surgical technique for deep stromal, anterior lamellar keratoplasty Gerrit R J Melles, Frank Lander, Frank J R Rietveld, Lies Remeijer, W Houdijn Beekhuis, Perry S Binder Iris cysts in children: classification, incidence, and management Jerry A Shields, Carol L Shields, Noemi Lois, Gary Mercado AIDS related eye disease in Burundi, Africa Isabelle Cochereau, Najoua Mlika-Cab , Philippe Godinaud, Théodore Niyongabo, Bernard Poste, Athanase Ngayiragije, Marie-Christine Dazza, Pierre Aubry, Bernard Larouzé Evaluation of visual outcome of cataract surgery in an Indian eye camp Harpreet Kapoor, Arin Chatterjee, Richard Daniel, Allen Foster Topographic anatomy of the eyelids, and the effects of sex and age Willem A van den Bosch, Ineke Leenders, Paul Mulder Measurement of retinal nerve fibre layer by scanning laser polarimetry and high pass resolution perimetry in normal tension glaucoma with relatively high or low intraocular pressure Motohiro Shirakashi, Shigeo Funaki, Haruko Funaki, Kiyoshi Yaoeda, Haruki Abe LABORATORY SCIENCE Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopatho- logical study SH Sarks,¥ #A rnold, M C Killingsworth, ¥ P Sarks Perspective Should diabetic patients be screened for glaucoma? John D Ellis, Andrew D Morris, Caroline ¥M acEwen for the DARTS/MEMO Collaboration Letters to the editor Correspondence Book reviews Notices Correction Instructions for authors No 4 APRIL 1999 Editorials The BO goes full text on the web; www.bjophthalmol.com John V Forrester Much more than water 7 Daniel Nelson Trends in vitreoretinal surgery—time to stop and think Peter K Leaver Commentary Measuring the burden of childhood blindness % S Rahi, C E Gilbert, A Foster, D Minassian Newsdesk Original articles CLINICAL SCIENCE Treatment of dry eye by autologous serum application in Sjégren’s syndrome Kazuo Tsubota, Eiki Goto, Hiromi Fujita, Masafumi Ono, Hiroko Inoue, Ichiro Saito, Shigeto Shimmura Trends in vitreoretinal surgery at a tertiary referral centre: 1987 to 1996 F G Ah-Fat, M C Sharma, M A Majid, IN McGalliard, D Wong Amniotic membrane transplantation for ocular surface reconstruction Augusto Azuara-Blanco, C TP illai, Harminder S Dua Proposed classification for topographic patterns seen after penetrating keratoplasty Constantinos H Karabatsas, Stuart D Cook, John M Sparrow Haemophilus influenzae associated scleritis Scott O Sykes, Christopher Riemann, Carmen I Santos, David M Meisler, Careen Y Lowder, John P Whitcher, Emmett T Cunningham Fr Allo-limbal transplantation in patients with limbal stem cell deficiency Harminder S Dua, Augusto Azuara-Blanco Assessment of macular function by multifocal electroretinogram before and after macular hole surgery Ying-Fie Si, Shoji Kishi, Koji Aoyagi Dopamine use is an indicator for the development of threshold retinopathy of prematurity Michael B Mizoguchi, Thomas G Chu, Frederick M Murphy, Neil Willits, Lawrence S Morse Indocyanine green angiographic features prognostic of visual outcome in the natural course of patients with age related macular degeneration Akira Obana, Yuko Gohto, Muneaki Matsumoto, Tokuhiko Miki, Kazuteru Nishiguti OCT imaging of choroidal neovascularisation and its role in the determination of patients’ eligibility for surgery A Giovannini, G P Amato, C Mariotti, B Scassellati-Sforzolini Endoscopic laser recanalisation of presaccal canalicular obstruction Andreas Kuchar, Philipp Novak, Stefan Pieh, Marcus Fink, Franz Josef Steinkogler Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma Marc D de Smet, Virginia Stark Vancs, David Kohler, Diane Solomon, Chi Chao Chan Lens epithelial changes and mutated gene expression in patients with myotonic dystrophy Toshiaki Abe, Masami Sato, Junko Kuboki, Tetsuya Kano, Makoto Tamai The triple procedure: in the bag placement versus ciliary sulcus placement of the intraocular lens Vincent M Borderie, Olivier Touzeau, Tristan Bourcier, Santos Carvajal-Gonzalez, Laurent Laroche Diabetes mc!litus: a risk factor in patients with Graves’ orbitopathy Rachel Kalmann, Maarten Ph Mourits Peripapillary retinal blood flow in normal tension glaucoma Hak Sung Chung, Alon Harris, Larry Kagemann, Bruce Martin Ophthalmic and visual profile of guide dog owners in Scotland K Refson, A ¥ Jackson, A E Dusoir, D B Archer LABORATORY SCIENCE Modulating phenotype and cytokine production of leucocytic retinal infiltrate in experimental autoimmune uveoretinitis following intranasal tolerance induction with retinal antigens Barbara Laliotou, Andrew D Dick Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathy Gillian Smith, David McLeod, David Foreman, Mike Boulton Perspective Head mounted video magnification devices for low vision rehabilitation: a comparison with existing technology Robert Harper, Louise Culham, Christine Dickinson Letters to the editor In memoriam Book reviews Notices Instructions for authors No 5 MAY 1999 Editorials Brain injury and ocular motor abnormalities in surviving preterm infants Anthony T Moore Criteria for cataract surgery: the role of visual acuity and visual function Andrew F Smith Commentary Ophthalmic medical assistants: response Alistair Fielder, Helen Pointer, Chris Timms Newsdesk Original articles CLINICAL SCIENCE Risk factors for strabismus in children born before 32 weeks’ gestation Philippa M Pennefather, Michael P Clarke, Nicholas P Strong, David G Cottrell, Jonathan Dutton, Win Tin Measuring visual symptoms in British cataract patients: the cataract symptom scale H L Crabtree, A } Hildreth, J E O'Connell, P S Phelan, D Allen, C S Gray Randomised clinical trial of lensectomy versus lens aspiration and primary capsulotomy for children with bilateral cataract in south India Michael Eckstein, P Vijayalakshmi, Clare Gilbert, Allen Foster Traumatic wound rupture after penetrating keratoplasty in Africa RC Bowman, D Yorston, T C Aitchison, B McIntyre, C M Kirkness Aetiological study of the presumed ocular histoplasmosis syndrome in the Netherlands 7 V Ongkosuwito, L M Kortbeek, A Van der Lelij, E Molicka, A Kijlstra, M D de Smet, M S A Suttorp-Schulten Treatment of immune recovery vitritis with local steroids Hugo W A Henderson, Suzanne M Mitchell Patients’ perception of visual impairment in glaucoma: a pilot study Patricia Nelson, Peter Aspinall, Colm O’Brien Pilocarpine induces an increase in the anterior chamber angular width in eyes with narrow angles Hiroshi Kobayashi, Kaori Kobayashi, Funichii Kiryu, Takehisa Kondo Ultrasound biomicroscopic measurement of development of anterior chamber angle Hiroshi Kobayashi, Hisako Ono, Junichii Kiryu, Kaori Kobayashi, Takehisa Kondo Natural history of diabetic macular streak exudates: evidence from a screening programme H L Cook, R Newsom, V Long, S A Smith, JS Shilling, M R Stanford Effect of aging on optic nerve appearance: a longitudinal study Frank ¥ Moya, Luca Brigatti, Joseph Caprioli Estimation of the retinal nerve fibre layer thickness in the papillomacular area of long standing stage IV macular holes Alex Assi, Patrick Watts, James McAllister Smoking as an aetiological factor in a pedigree with Leber’s hereditary optic neuropathy Kailenn Tsao, Phil A Aitken, Donald R Johns Natural history of amblyopia untreated owing to lack of compliance Kurt Simons, Mark Preslan Modelling uveal melanoma Alexander 7 E Foss, lan A Cree, Paul ¥ Dolin, John L Hungerford Incidence of eyelid cancers in Singapore from 1968 to 1995 Sao-Bing Lee, Seang-Mei Saw, Kah-Guan Au Eong, Tat-Keong Chan, Hin-Peng Lee LABORATORY SCIENCE Dendritic cells and macrophages in the uveal tract of the normal mouse eye Paul G McMenamin Significance of serum antibodies reactive with flavoprotein subunit of succinate dehydrogenase in thyroid associated orbitopathy Banu M Hosal, Fil K Swanson, Charlotte R Thompson, Sumihisa Kubota, Kazuaki Gunji, John S Kennerdell, Jack R Wall Analysis of glycosaminoglycans in rabbit cornea after excimer laser keratectomy Takuji Kato, Kiyoo Nakayasu, Kazuyuki Ikegami, Takeo Obara, Toshiji Kanayama, Atsushi Kanai ATP binding cassette transporter retina genotypes and age related macular degeneration: an analysis on exudative non-familial Japanese patients Sachiko Kuroiwa, Hidenobu Kojima, Takanobu Kikuchi, Nagahisa Yoshimura Correlation of histological findings with gadolinium enhanced MRI scans during healing of a PHEMA orbital implant in rabbits Celia R Hicks, lan T Morris, Sarojini Vijayasekaran, Michael } Fallon, Jordana McAllister, Anthony B Clayton, Traian V Chirila, Geoffrey 3C rawford, lan ¥ Constable Perspective Diagnosis of viral and chlamydial keratoconjunctivitis: which laboratory test? Elfath M Elnifro, Robert ¥C ooper, Paul E Klapper, Andrew S Bailey, Andrew B Tullo Letters to the editor Correspondence Notices Instructions for authors No 6 JUNE 1999 Editorials Bias: adding to the uncertainty John M Sparrow, John R Thompson Science! Why should the clinician care? Amanda 3 Churchill Commentary Posterior capsular opacification prevention: IOL design and material Andrew Coombes, Helen Seward Newsdesk Original articles CLINICAL SCIENCE Bias due to incomplete follow up in a cohort study PM Pennefather, W Tin, M P Clarke, ¥D utton, S Fritz, E N Hey Radiotherapy for isolated occult subfoveal neovascularisation in age related macular degeneration: a pilot study Guy Donati, Dominique Soubrane, Maddalena Quaranta, Gabriel Coscas, Gisele Soubrane Cytomegalovirus retinitis after the initiation of highly active antiretroviral therapy: a 2 year prospective study Suzanne M Mitchell, William L Membrey, Michael S Youle, Adanna Obi, Simon Worrell, Brian G Gazzard Image quality in polypseudophakia for extremely short eyes CC Hull,C S C Liu, A Sciscio Inter- and intraobserver variation in the analysis of optic disc images: comparison of the Heidelberg retina tomo- graph and computer assisted planimetry D F Garway-Heath, D Poinoosawmy, G Wollstein, A Viswanathan, D Kamal, L Fontana, R A Hitchings Chronic cortical visual impairment in children: aetiology, prognosis, and associated neurological deficits Richard Huo, Susan K Burden, Creig S Hoyt, William V Good Preschool vision screening: negative predictive value for amblyopia Douglas K Newman, Miranda M East Ocular ochronosis in alkaptonuria patients carrying mutations in the homogentisate 1,2-dioxygenase gene Ute Felbor, Yvonne Mutsch, Franz Grehn, Clemens R Miiller, Wolfram Kress Decreased tear lactoferrin concentration in patients with chronic hepatitis C Tohru Abe, Ako Nakajima, Mutsumi Matsunaga, Shozo Sakuragi, Masafumi Komatsu Ocular signs and symptoms and vitamin A status in patients with cystic fibrosis treated with daily vitamin A supplements Ejaz A Ansari, Kamal Sahni, Christine Etherington, Alison Morton, Steven P Conway, Eduardo Moya, James M Littlewood Treatment of obstructive epiphora in adults by balloon dacryocystoplasty Zeynep Yazici, Bulent Yazict, Mufit Parlak, Haluk Erturk, Gursel Savei Confocal microscopy in the iridocorneal endothelial syndrome Auguste G-Y Chiou, Stephen C Kaufman, Roger W Beuerman, Toshihiko Ohta, Volkan Yaylali, Herbert E Kaufman Iris crystals in chronic uveitis Andrew B Callear, Anita Reynolds, John Harry, Philip I Murray The Bristol Shared Care Glaucoma Study: reliability of community optometric and hospital eye service test measures PG D Spry, IC Spencer, JM Sparrow, T F Peters, S T Brookes, S Gray, I Baker, JE Furber, D L Easty Effect of diode laser trans-scleral cyclophotocoagulation in the management of glaucoma after intravitreal silicone oil injection for complicated retinal detachments Soo Kyung Han, Ki Ho Park, Dong Myung Kim, Bong Leen Chang Selective laser trabeculoplasty v argon laser trabeculoplasty: a prospective randomised clinical trial Karim F Damyi, Kirtida C Shah, William ¥ Rock, Harkaran S Bains, William G Hodge LABORATORY SCIENCE PAX6 expression in the developing human eye Sachiko Nishina, Shinichi Kohsaka, Yuki Yamaguchi, Hiroshi Handa, Atsushi Kawakami, Hajime Fujisawa, Noriyuki Azuma Growth factor staining patterns in the pig retina following retinal laser photocoagulation Ming Xiao, David McLeod, John Cranley, Gillian Williams, Mike Boulton Antimicrobial defensin peptides of the human ocular surface Richard John Haynes, Patrick Jason Tighe, Harminder Singh Dua Ocular adnexal lymphoma—comparison of MALT lymphoma with other histological types Mark Cahill, Colma Barnes, Paul Moriarty, Peter Daly, Susan Kennedy Perspective Amniotic membrane transplantation Harminder S Dua, Augusto Azuara-Blanco Letters to the editor Mailbox Book review Notices Instructions for authors No 7 JULY 1999 Editorial A role for hepatocyte growth factor in diabetic retinopathy? Mike Boulton Commentary Writing to our patients G Jayakrishna Menon, Gordon N Dutton Newsdesk Original articles CLINICAL SCIENCE New treatment of dry eye: the effect of calcium ointment through eyelid skin delivery Kazuo Tsubota, Yu Monden, Yukiko Yagi, Eiki Goto, Shigeto Shimmura Identification and antibiotic susceptibility of coagulase negative staphylococci isolated in corneal/external infections Antonio Pinna, Stefania Zanetti, Mario Sotgiu, Leonardo A Sechi, Giovanni Fadda, Francesco Carta Evaluation of corneal thickness and topography in normal eyes using the Orbscan corneal topography system Zuguo Liu, Andrew ¥ Huang, Stephen C Pflugfelder Topographic and keratometric astigmatism up to 1 year following small flap trabeculectomy (microtrabeculectomy) SA Vernon, H } Zambarakji, F Potgieter, ¥E vans, P B Chelil Early retreatment of infantile esotropia: comparison of reoperation and botulinum toxin aime Tejedor, José M Rodriguez Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery Jeong-Min Hwang, Bong Leen Chang Creation and testing of a practical visual function assessment for use in Africa: correlation with visual acuity, contrast sensitivity, and near vision in Malawian adults Karin van Dijk, Susan Lewallen, Moses Chirambo, Jane Gardiner, Brian Hoar, Janette Lindley, N Kevin Wade, Paul Courtright Visual performance in giant cell arteritis (temporal arteritis) after 1 year of therapy Mark ¥ Kupersmith, Regina Langer, Hal Mitnick, Robert Spiera, Harry Spiera, Marjorie Richmond, Stephen Paget Clinical and genetic heterogeneity in autosomal dominant cataract Alexander Ionides, Peter Francis, Vanita Berry, Donna Mackay, Shomi Bhattacharya, Alan Shiels, Anthony Moore Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change David W Evans, Alon Harris, Melanie Garrett, Hak Sung Chung, Larry Kagemann Risk factors for failures of trabeculectomies performed without antimetabolites Holger Mietz, Birgit Raschka, Giinter K Krieglstein Subtraction ICG angiography in Harada’s disease Takeya Kohno, Tokuhiko Miki, Kunihiko Shiraki, Kiyoshi Kano, Michiko Matsushita, Kazuhiko Hayashi, Jean Jacques De Laey LABORATORY SCIENCE Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus Kei Shinoda, Susumu Ishida, Shinichi Kawashima, Toshiko Wakabayashi, Tadayuki Matsuzaki, Michiyo Takayama, Ken Shinmura, Masakazu Yamada Angiogenic factors in human proliferative sickle cell retinopathy Fingtai Cao, Michaela Kunz Mathews, D Scott McLeod, Carol Merges, Leonard M Hijelmeland, Gerard A Lutty Soluble ICAM-1 serum levels in patients with intermediate uveitis Anne-Marie Klok, Leny Luyendijk, Michel 7 W Zaal, Aniki Rothova, Aize Kilstra Dynamics of phosphorothioate oligonucleotides in normal and laser photocoagulated retina Wéei-Yong Shen, Kerryn L Garrett, Lyndon da Cruz, lan } Constable, Piroska E Rakocz Morphological variations of the peripapillary circle of Zinn—Haller by flat section Myung-Kyoo Ko, Dong-Seob Kim, Yoon-Koo Ahn Perspective Macular pigment and age related macular degeneration S Beatty, M Boulton, D Henson, H-H Koh, I ¥ Murray Letters to the editor Mailbox Book reviews Notices No 8 AUGUST 1999 Page Editorials 889 Cataract surgery—quantity and quality Richard Wormald 890 Wellcome Trust support for vision research John R Stephenson 892 Newsdesk Original articles CLINCAL SCIENCE Profile of patients presenting for cataract surgery in the UK: national data collection Parul Desai, Angela Reidy, Darwin C Minassian Audit of extracapsular cataract extraction and posterior chamber lens implantation as a routine treatment for age related cataract in east Africa David Yorston, Allen Foster Automated localisation of the optic disc, fovea, and retinal blood vessels from digital colour fundus images Chanyira Sinthanayothin, James F Boyce, Helen L Cook, Thomas H Williamson Effect of software manipulation (Photcshop) of digitised retinal images on the grading of diabetic retinopathy L D George, ¥L usty, D R Owens, R L Ollerton Phenotypic variations in a family with retinal dystrophy as result of different mutations in the ABCR gene B Jeroen Klevering, Marc van Driel, Dorien ¥ R van de Pol, Alfred }L G Pinckers, Frans P M Cremers, Carel B Hoyng Phenotype of autosomal recessive congenital microphthalmia mapping to chromosome 14q32 David A R Bessant, Khalid Anwar, Shagufta Khaliq, Abdul Hameed, M Ismail, Annette M Payne, S Qasim Mehdi, Shomi S Bhattacharya Long term results of radiotherapy for subfoveal choroidal neovascularisation in age related macular degeneration Martine Mauget-Faysse, Christophe Chiquet, Dan Milea, Pascale Romestaing, Jean-Pierre Gérard, Philippe Martin, Frangotse Koenig Causes of childhood blindness in the People’s Republic of China: results from 1131 blind school students in 18 provinces S ¥ Hornby, Y Xiao, C E Gilbert, A Foster, X Wang, X Liang, H Fing, L Wang, W Min, Y Shi, Y Li Eye injuries in children: the current picture Caroline }M acEwen, Paul S Baines, Parul Desai Population based assessment of diabetic retinopathy in an urban population in southern India Lalit Dandona, Rakhi Dandona, Thomas J Naduvilath, Catherine A McCarty, Gullapalli N Rao Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7 M McKibbin, F D Isaacs, A J Morrell Prophylactic scleral buckle for prevention of retinal detachment following vitrectomy for macular hole Tom S Chang, Ed McGill, Dawn A Hay, William H Ross, Alan L Maberley, Lyn M Sibley, Patrick E Ma, Michael F Potter Endoscopy of the lacrimal system Klaus Miillner, Elisabeth Bodner, Geva E Mannor LABORATORY SCIENCE Vitreous levels of intercellular adhesion molecule 1 (ICAM-1) as a risk indicator of proliferative vitreoretinopathy G Astrid Limb, Anthony H Chignell Detection of herpes simplex virus DNA in atypical epithelial keratitis using polymerase chain reaction Noriko Koizumi, Kohjt Nishida, Wakako Adachi, Mamoru Tei, Yoichi Honma, Atsuyoshi Dota, Chie Sotozono, Norithiko Yokoi, Shuji Yamamoto, Shigeru Kinoshita Effect of the cytostatic agent idarubicin on fibroblasts of the human Tenon’s capsule compared with mitomycin C Claudia Heilmann, Peter Schénfeld, Thomas Schliiter, Ralf Bohnensack, Wolfgang Behrens-Baumann New animal model for human ocular toxocariasis: ophthalmoscopic observation Tomoko Hara Takayanagi, Nobuaki Akao, Ryoko Suzuki, Misato Tomoda, Setsuko Tsukidate, Koichiro Fujita Suppression of induction of experimental immune mediated blepharoconjunctivitis by tolerogenic conjugates of the antigen and monomethoxypolyethylene glycol Atsuki Fukushima, Koji Nishino, Hironori Yoshida, Masaru Takata, Hisayuki Ueno Perspective Ganglion cell death in glaucoma: what do we really know? Neville N Osborne, John PM Wood, Glyn Chidlow, Fi-Hong Bae, José Melena, Mark S Nash Letters to the editor Mailbox Book reviews Notices Instructions for authors No 9 SEPTEMBER 1999 Page Editorial 999 The well tempered crystal ball in normal tension glaucoma Stephen A Vernon 1001 Newsdesk Original articles CLINICAL SCIENCE Clinical factors influencing the visual prognosis of the fellow eyes of normal tension glaucoma patients with unilateral field loss Luigi Fontana, Rodolfo Armas, David F Garway-Heath, Catey V Bunce, Darmalingum Poi ry, Roger A Hitchings Is a tight patch necessary after trabeculectomy? G E Trope, Y M Buys, 7F lanagan, L Wang “Orientation teeth” in non-mechanical laser corneal trephination for penetrating keratoplasty: 2.94 um Er:YAG v 193 nm ArF excimer laser Ashley Behrens, Berthold Seitz, Michael Kiichle, Achim Langenbucher, Murat M Kus, Carmen Rummelt, Gottfried O H Naumann LASIK for post penetrating keratoplasty astigmatism and myopia Suzanne K Webber, Michael A Lawless, Gerard L Sutton, Christopher M Rogers Microbial decontamination of human donor eyes with povidone-iodine: penetration, toxicity, and effectiveness E Pels,G F 7 M Vrensen Risk factors for treatment outcome of suspected microbial keratitis Nigel Morlet, Darwin Minassian, Jeremy Butcher, and the Ofloxacin Study Group Comparison of dacryocystography and lacrimal scintigraphy in the diagnosis of functional nasolacrimal duct obstruction Michael J Wearne, John Pitts, John Frank, Geoffrey E Rose Visual outcome after phacoemulsification and IOL implantation in diabetic patients Anna Zaczek, Géran Olivestedt, Charlotta Zetterstrém Diabetic versus non-diabetic colour vision after cataract surgery Line Kessel, Anita Alsing, Michael Larsen Treatment of retinal tears and lattice degenerations in fellow eyes in high risk patients suffering retinal detachment: a prospective study Leonardo Mastropasqua, Paolo Carpineto, Marco Ciancaglini, Gennaro Falconio, Pier E Gallenga Intravitreal dexamethasone in exogenous bacterial endophthalmitis: results of a prospective randomised study Taraprasad Das, Subhadra Jalali, Vijaya K Gothwal, Savitri Sharma, Thomas ¥ Naduvilath Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study L Luis Masmiquel, Rosa Burgos, Carlos Mateo, Ramon Marti, Rosa M Segura, Rafael Simo Everting suture correction of lower lid involutional entropion Mark Wright, Dugald Bell, Chris Scott, Brian Leatherbarrow LABORATORY SCIENCE Concentration dependent effects of hydrogen peroxide on lens epithelial cells Nobuyuki Ohguro, Masakatsu Fukuda, Tetsuo Sasabe, Yasuo Tano a/B— and y/6 TCR+ lymphocyte infiltration in necrotising choroidal melanomas AlexanderA Bialasiewicz, Fin- Xue Ma, Gisbert Richard IL-4 regulates chemokine production induced by TNF-a in keratocytes and corneal epithelial cells Yoji Takano, Kazumi Fukag Shigeto Shi ‘a, Kazuo Tsubota, Yoshihisa Oguchi, Hirohisa Saito Culture and characterisation of epithelial cells from human pterygia Nick Di Girolamo, Nicodemus Tedla, Rakesh K Kumar, Peter McCluskey, Andrew Lloyd, Minas T Coroneo, Denis Wakefield Perspective Hypertension and diabetic retinopathy—what’s the story? ¥ T Gillow, ¥M Gibson, P M Dodson Letters to the editor Mailbox Book reviews Notices Instructions for authors No 10 OCTOBER 1999 Page Editorial 1101 Penetrating injury of the eye Paul McCormack Commentary 1103 Photocoagulation of subfoveal choroidal neovascular membranes in age related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland S Beatty, K G Au Eong, D McLeod, P N Bishop Newsdesk Original articles CLINICAL SCIENCE Simulation model of an eyeball based on finite element analysis on a supercomputer Etichi Uchio, Shigeaki Ohno, Foju Kudoh, Koki Aoki, Lech Tomasz Kisielewicz Amblyopia and visual acuity in children with Down’s syndrome William G Tsiaras, Sigfried Pueschel, Charles Keller, Robert Curran, Stephan Giesswein A vision specific functional index for use in patients with age related macular degeneration PM Hart, U Chakravarthy, M R Stevenson, ¥ Q Famison Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome Patrick I Condon, Charles G McEwen, Mark Wright, Graeme Mackintosh, Robin ¥ Prescott, Carolyn McDonald Dry eye after haematopoietic stem cell transplantation Yoko Ogawa, Shinichiro Okamoto, Masatoshi Wakui, Reiko Watanabe, Masakazu Yamada, Mami Yoshino, Masafumi Ono, Hao-Yung Yang, Yukihiko Mashima, Yoshihisa Oguchi, Yasuo Ikeda, Kazuo Tsubota New equipment to prevent carbon dioxide rebreathing during eye surgery under retrobulbar anaesthesia A Schlager, Hubert Staud Retained intravitreal lens fragments after phacoemulsification: a clinicopathological correlation LM W Yeo, D G Charteris, C Bunce, P ¥ Luthert, Z ¥ Gregor Choroidal folds and papilloedema Lorraine M Cassidy, Michael D Saunders Difference between RP2 and RP3 phenotypes in X linked retinitis pigmentosa Christina J Flaxel, Marcelle fay, Dawn L Thiselton, Mani Nayudu, Alison J Hardcastle, Alan Wright, Alan C Bird Ocular manifestations in children and adolescents with Lyme arthritis Hans-Iko Huppertz, Doris Miinchmeier, Wolfgang Lieb Anterior uveitis associated with intravenous’ cidofovir use in patients with cytomegalovirus retinitis Jayakrishna Ambati, Kevin B Wynne, Mary C Angerame, Michael R Robinson Grading nuclear cataract: reproducibility and validity of anew method Nigel F Hall, Philip Lempert, Rosaleen P Shier, Rahila Zakir, David Phillips Laser pointers revisited: a survey of 14 patients attending casualty at the Bristol Eye Hospital C S Sethi, R HB Grey, C Dean Hart LABORATORY SCIENCE Cell and protein adhesion studies in glaucoma drainage device development The AGFID project team Effect of trephination technique on the ultrastructure of corneal transplants: guided trephine system v posterior punch technique W Radner, Ch Skorpik, R Loewe, C Mudrich,G Radner, R Mallinger Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies Kohji Nishida, Andrew ¥ Quantock, Atsuyoshi Dota, Nam-Ho Choi-Miura, Shigeru Kinoshita Scientific correspondence Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid Osman Cekig, Cosar Batman, Umit Yasar, Yiiksel Totan, Nursabah E Basci, Atilla Bozkurt, Orhan Zilelioglu, S Oguz Kayaalp Influence of highly active antiretroviral therapy on the development of CMV disease in HIV positive patients at high risk for CMV disease Frank D Verbraak, René Boom, Pauline M E Wertheim-van Dillen, Gerardus ¥ van den Horn, Aize Kijlstra, Marc D de Smet Perspective Risk factors for intraocular melanoma and occupational exposure Jean-Michel Lutz, lan A Cree, Alex } Foss Letters to the editor Mailbox Book reviews Notices Instructions for authors No 11 NOVEMBER 1999 Editorial Impact of new technologies in ophthalmology John V Forrester Commentary Transpupillary thermotherapy of choroidal melanoma with or without brachytherapy: a dilemma J E E Keunen, F G Fournéwe-de Korver,J A Oosterhuis Newsdesk Perspectives Ophthalmology in the post-genomic era GC M Black, M E Boulton, P N Bishop, D McLeod Molecular therapy in ocular wound healing M Francesca Cordeiro, Gregory S Schultz, Robin R Ali, Shomi S Bhattacharya, Peng T Khaw New developments in sustained release drug delivery for the treatment of intraocular disease Gisela Vélez, Scott M Whitcup Immunomodulation of autoimmune responses with monoclonal antibodies and immunoadhesins: treatment of ocular inflammatory disease in the next millennium Andrew D Dick, John D Isaacs Closer to nature: new biomaterials and tissue engineering in ophthalmology Bruce Allan Laser imaging of the retina PF Sharp, AM anivannan, P Vieira, ¥H Hipwell New applications in ultrasound technology H R Atta Scanning laser ophthalmoscopy and fundus fluorescent leucocyte angiography Parwez Hossain Telemedicine Jan Murdoch Refractive surgery Peter ¥M cDonnell Eradication of trachoma worldwide David Mabey, Robin Bailey Information technology in ophthalmology—experience with an electronic patient record G W Aylward, D N Parmar Original articles CLINICAL SCIENCE Mycophenolate mofetil versus cyclosporin A in high risk keratoplasty patients: a prospectively randomised clinical trial Alexander Reis, Thomas Reinhard, Adina Voiculescu, Bernd Kutkuhn, Erhard Godehardt, Helga Spelsberg, Christoph Althaus, Rainer Sundmacher Outcome of cataract surgery considering the preoperative situation: a study of possible predictors of the functional outcome Mats Lundstrim, Ulf Stenevi, William Thorburn Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients Jeroen van Root, Sicco G W S thoe Schwartzenberg, Paul G H Mulder, Seerp G Baarsma Measuring colour rivalry suppression in amblyopia Timothy S Hofeldt, Albert ¥H ofeldt LABORATORY SCIENCE Hyperhomocysteinaemia in young patients with non-arteritic anterior ischaemic optic neuropathy Aki Kawasaki, Valerie A Purvin, Richard A Burgett Localised retinal nerve fibre layer defects in chronic experimental high pressure glaucoma in rhesus monkeys Jost B Jonas, Sohan Singh Hayreh Scientific correspondence Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse tran- scription polymerase chain reaction JA El-Ghrably, Harminder S Dua, Gavin M Orr, David Fischer, Patrick } Tighe Rhinostomies: an open and shut case? Chris ¥ McLean, lan A Cree, Geoffrey E Rose Corneal wound healing following laser in situ keratomileusis (LASIK): a histop. ological study in rabbits Takuji Kato, Kivoo Nakayasu, Yuji Hosoda, Yasuo Watanabe, Atsushi Kanai Letters to the editor Mailbox Notices Correction Instructions for authors No 12 DECEMBER 1999 Editorial Importance of early diagnosis of retinoblastoma Jerry A Shields Commentary Advancing microsurgical instrumentation into the 21st century A Waldock, T A Waldock Newsdesk Original articles CLINICAL SCIENCE Delay in diagnosis of retinoblastoma: risk factors and treatment outcome Andrea G Goddard, Judith E Kingston, John L Hungerford Ocular arterial blood flow of choroidal melanoma eyes before and after stereotactic radiotherapy using Leksell gamma knife: 2 year follow up Pia V Vécsei, Karl Kircher, Gunda Nagel, Sabine Toma-Bstaendig, Irene Ruhswurm, Michael Georgopoulos, Martin Zehetmayer Perifoveal microcirculation in eyes with epiretinal membranes Kazuaki Kadonosono, Northiko Itoh, Etichi Nomura, Shigeaki Ohno Alterations in the conjunctival bacterial flora following a single dose of azithromycin in a trachoma endemic area Kenneth C Chern, S K Shrestha, Vicky Cevallos, H L Dhami, Pawan Tiwari, Laurie Chern, John P Whitcher, Tho- mas M Lietman National cataract surgery survey 1997-8: a report of the results of the clinical outcomes Parul Desai, DC Minassian, Angela Reidy Full text reading with a central scotoma: pseudo regressions and pseudo line losses Avinoam B Safran, Flor- ence Duret, Marc Issenhuth, Christophe Mermoud Randomised controlled trial of corticosteroid regimens in endothelial corneal allograft rejection 7 Hudde, DC Minassian, D F P Larkin LABORATORY SCIENCE Cellular photoablation to control postoperative fibrosis in a rabbit model of filtration surgery Salvatore Grisanti, Michael Diestelhorst, Klaus Heimann, Giinter Krieglstein Soluble Fas and Fas ligand in human tear fluid after photorefractive keratectomy I/po Tuominen, Minna Vesali Anna-Maija Teppo, Carola Grénhagen-Riska, Timo Tervo Cell subpopulations in failed human corneal grafts Lucia Kuffova, Vladimir Holan, Lynne Lumsden, John V Forrester, Martin Filipec Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine Klaus Trier, Elith Bjarne Olsen, Takasi Kobayashi, Seren Munk Ribel-Madsen Role of ocular matrix metalloproteinases in peripheral ulcerative keratitis VA Smith, H B Hoh, D L Easty Scientific correspondence Environmental scanning electron microscopic study of macrophages associated with the tunica vasculosa lentis in the developing rat eye 7% Djano, B Griffin, I van Bruggen, PG McMenamin CD56+ T cells in the peripheral blood of uveitis patients Hitoshi Yato, Yoshihiro Matsumoto Ocular complications of acoustic neuroma surgery M G Mulhern, P M Aduriz-Lorenzo, D Rawluk, L Viani, P Eustace, P Logan The pituitary-adrenal axis in idiopathic retinal vasculitis H E Palmer, M R Stanford, C Lowy, M F Wheeler, G R Wallace, EM Graham Perspective Acquired colour vision defects in glaucoma—their detection and clinical significance Mireia Pacheco-Cutillas, Arash Sahraie, David F Edgar Letters to the editor Mailbox Book reviews Notices Author index Subject index Contents

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VOLUME 83 - CONTENTS No 1 JANUARY 1999 Page Editorials 1 “New” surgical treatments for glaucoma PT Khaw, D Siriwardena 3 Progress in diabetic maculopathy Tom Barrie Commentary Ophthalmic medical assistants SK Webber, M N Jeffrey Newsdesk Original articles CLINICAL SCIENCE Deep sclerectomy with collagen implant: medium term results Marc E Karlen, Enrique Sanchez, Corinne C Schnyder, Michel Sickenberg, André Mermoud Vitrectomy for cystoid macular oedema with attached posterior hyaloid membrane in patients with diabetes Tomohiro Ikeda, Keiko Sato, Takuya Katano, Yasuhito Hayashi Mid-peripheral pattern electrical retinal responses in normals, glaucoma suspects, and glaucoma patients Neal H Shorstein, William W Dawson, Mark B Sherwood Retrospective analysis of risk factors for late presentation of chronic glaucoma Scort Fraser, Catey Bunce, Richard Wormald Immediate intraocular pressure response to selective laser trabeculoplasty Paolo Lanzetta, Ugo Menchini, Gianni Virgili Effect of acute intraocular pressure changes on short posterior ciliary artery haemodynamics Karen M Joos, Matthew D Kay, L E Pillunat, Alon Harris, E Kym Gendron, W ¥ Feuer, Brett E Steinwand High incidence of glucose intolerance in Vogt-Koyanagi—Harada disease Nobuyo Yawata, Satoshi Nakamura, Masaya Kijima, Nakako Ikai, Mitsuyo Kanai, Miyuki Sugita, Shigeaki Ohno Preretinopic changes in the colour vision of juvenile diabetics Anne Kurtenbach, Ulrich Schiefer, Andreas Neu, Eberhart Zrenner Cystoid macular oedema and cytomegalovirus retinitis in patients with HIV disease treated with highly active antiretroviral therapy Nathalie Cassoux, Livia Lumbroso, Bahram Bodaghi, Lydie Zazoun, Christine Katlama, Phuc LeHoang Arterial blood flow characteristics in central retinal vein occlusion and effects of panretinal photocoagulation treatment: an investigation by colour Doppler imaging Avni Murat Avunduk, Hasan Ding, Zerrin Kapicwéglu, Saban Ugurlu, Volkan Dayan, Ercan Korkmaz Quantitative assessment of macular thickness in normal subjects and patients with diabetic retinopathy by scanning retinal thickness analyser Yusuke Oshima, Kazuyuki Emi, Shigeki Yamanishi, Masanobu Motokura The need for cataract surgery: projections based on lens opacity, visual acuity, and personal concern Cathy A McCarty, fill E Keeffe, Hugh R Taylor Measuring the effectiveness of cataract surgery: the reliability and validity of a visual function outcomes instrument D ¥ Lawrence,C Brogan, L Benjamin, D Pickard, S Stewart-Brown Results of small incision extracapsular cataract surgery using the anterior chamber maintainer without viscoelastic Mark Wright, Hector Chawla, Alistair Adams Orbital lymphangioma: an analysis of 26 patients Murat Tung, Ehsan Sadri, Devron H Char A single technique to correct various degrees of upper lid retraction in patients with Graves’ orbitopathy Maarten Ph Mourits, Inna Vladimirovna Sasim Long term results after surgical basal cell carcinoma excision in the eyelid region Stefan Pieh, Andreas Kuchar, Philipp Novak, Rainer Kunstfeld, Gunda Nagel, F ¥ Steinkogler Diseases associated with ocular surface abnormalities: the importance of reflex tearing Kazuo Tsubota, Minako Kaido, Yukiko Yagi, Tsutomu Fujihara, Shigeto Shimmura Reflective meniscometry: a non-invasive method to measure tear meniscus curvature Northiko Yokoi, Anthony Bron, John Tiffany, Nicholas Brown, James Hsuan, Colin Fowler Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases Murat Tunc, Devron H Char, Brooks Crawford, Theodore Miller Peribulbar anaesthesia during keratoplasty: a prospective study of 100 cases Marc Muraine, Emile Calenda, Laure Watt, Nicole Proust, Annie Cardon, Laurent Eupherte, Gerard Brasseur LABORATORY SCIENCE c-myc, p53, and Bel-2 expression and clinical outcome in uveal melanoma 7S Chana, G D Wilson, I A Cree, RA Alexander, N Myatt, M Neale, A ¥ E Foss, ¥ L Hungerford Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial dystrophy (CHED) and autosomal dominant CHED are genetically distinct Maire Callaghan, Collette K Hand, Susan M Kennedy, ¥S usan FitzSimon, Louis M T Collum, Nollaig A Parfrey Perspective Management of inherited outer retinal dystrophies: present and future N H Victor Chong, Alan C Bird Letters to the editor Correspondence Obituary Notices Instructions for authors No 2 FEBRUARY 1999 Page Editorials 131 The “thin man” phenomenon: imperfect filling in of visual space Neil R Miller 132 The healing optic nerve in glaucoma: transforming growth factor f and optic nerve head remodelling M F Cordeiro, P T Khaw Commentary Distribution of azithromycin for the treatment of trachoma Kathryn I Taylor, Hugh R Taylor Newsdesk Original articles CLINICAL SCIENCE The “thin man” phenomenon: a sign of cortical plasticity following inferior homonymous paracentral scotomas Avinoam B Safran, Olivier Achard, Florence Duret, Theodor Landis Ophthalmological follow up of preterm infants: a population based, prospective study of visual acuity and strabismus G Holmstrim, M el Azazi, U Kugelberg Filtration procedures supplemented with mitomycin C in the management of childhood glaucoma Augusto Azuara-Blanco, Richard P Wilson, George L Spaeth, Courtland M Schmidt, James ¥ Augsburger Screening for refractive errors in children: accuracy of the hand held refractor Retinomax to screen for astigmatism Monique Cordonnier, Michéle Dramaix Effect of isosorbide mononitrate on the human optic nerve and choroidal circulations Juan E Grunwald, Alessandro lannaccone, Joan DuPont Indocyanine green guided laser photocoagulation in patients with occult choroidal neovascularisation Andreas W A Weinberger, Hildegard Knabben, Uta Solbach, Sebastian Wolf Infectious keratitis in leprosy Deepa John, Ebenezer Daniel Conjunctival squamous cell carcinoma in Tanzania TR G Poole Efficacy of nedocromil 2% versus fluorometholone 0.1%: a randomised, double masked trial comparing the effects on severe vernal keratoconjunctivitis Khalid F Tabbara, Soliman A Al-Kharashi Confocal microscopy in cornea guttata and Fuchs’ endothelial dystrophy Auguste G-Y Chiou, Stephen C Kaufman, Roger W Beuerman, Toshihiko Ohta, Hisham Soliman, Herbert E Kaufman Cone and rod dysfunction in the NARP syndrome Jtay Chowers, Tally Lerman-Sagie, Orly N Elpeleg, Avraham Shaag, Saul Merin Ring melanoma—a rare cause of refractory glaucoma Vickie Lee, lan A Cree, John L Hungerford Temporal contrast sensitivity with peripheral and central stimulation in glaucoma diagnosis Jsabel M Véelten, Matthias Korth, Folkert K Horn, Wido M Budde Comparison of inferior oblique muscle weakening by anterior transposition or myectomy: a prospective study of 20 cases Byung-Moo Min, Fu-Hee Park, Seung- Young Kim, Seong-Bok Lee LABORATORY SCIENCE Transforming growth factor $B isoforms in human optic nerve heads Janethe D O Pena, Andrew W Taylor, Cynthia S Ricard, Ivonne Vidal, M Rosario Hernandez Long term ultrastructural changes in human corneas after tattooing with non-metallic substances Walter Sekundo, Peter Seifert, Berthold Seitz, Karin U Loeffler Differential induction of proto-oncogene expression and cell death in ocular tissues following ultraviolet irradia- tion of the rateye Hannes Wickert, Kurt Zaar, Andreas Grauer, Markus John, Manfred Zimmermann, Frank Gillardon Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina Richard M Andrews, Philip G Griffiths, Margaret A Johnson, Douglass M Turnbull Human retina contains polyamine sensitive ['H]-ifenprodil binding sites: implications for neuroprotection? N A Sharif, S X Xu Perspective Birdshot retinochoroidopathy Alice T Gasch, Janine A Smith, Scott M Whitcup Letter to the editor Correspondence Book reviews Notices Correction Instructions for authors No 3 MARCH 1999 Page Editorials 257 Diabetic tractional papillopathy: a new (and true) nosological entity? David McLeod 258 Paediatric pseudophakia—choosing the implant power James D H Young 260 Newsdesk Original articles CLINICAL SCIENCE Vitreopapillary traction in proliferative diabetic vitreoretinopathy Peter Kroll, Wolfgang Wiegand, Joerg Schmidt Intraocular lenses in children: changes in axial length, corneal curvature, and refraction D I Flitcroft, D Knight-Nanan, R Bowell, B Lanigan, M O’Keefe Presumed ocular bartonellosis F T Kerkhoff, ¥M Ossewaarde, W S de Loos, A Rothova Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope Noemi Lois, Anthony S Halfyard, Catey Bunce, Alan C Bird, Fredrick W Fitzke Age over 46 years does not affect the pressure lowering effect of trabeculectomy in primary open angle glaucoma M C Briggs, JL Jay Follow up of focal narrowing of retinal arterioles in glaucoma Konstantinos I PapastathopoulosFo,s t B Jonas Detection of optic disc change with the Heidelberg retina tomograph before confirmed visual field change in ocular hypertensives converting to early glaucoma DS Kamal, A C Viswanathan, D F Garway-Heath, RA Hitchings, D Poinoosawmy, C Bunce Comparison between laser scanning tomography and computerised image analysis of the optic disc Augusto Azuara-Blanco, George L Spaeth, Jamie Nicholl, Ines M Lanzl, James ¥ Augsburger Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc Christian Y Mardin, Folkert K Horn, Jost B Jonas, Wido M Budde Course of exfoliation and simplex glaucoma after primary trabeculectomy Vadislav Popovic, Johan Sjéstrand “Cyclodiode”: results of a standard protocol Anne Fiona Spencer, Stephen A Vernon Prognosis of primary ab externo surgery for primary congenital glaucoma Thomas S Dietlein, Philipp C Facobi, Giinter K Krieglstein The eye in epidermolysis bullosa L Tong, P R Hodgkins, ¥D enyer, D Brosnahan, }H arper, I Russell-Eggitt, D SI Taylor, D Atherton A new surgical technique for deep stromal, anterior lamellar keratoplasty Gerrit R J Melles, Frank Lander, Frank J R Rietveld, Lies Remeijer, W Houdijn Beekhuis, Perry S Binder Iris cysts in children: classification, incidence, and management Jerry A Shields, Carol L Shields, Noemi Lois, Gary Mercado AIDS related eye disease in Burundi, Africa Isabelle Cochereau, Najoua Mlika-Cab , Philippe Godinaud, Théodore Niyongabo, Bernard Poste, Athanase Ngayiragije, Marie-Christine Dazza, Pierre Aubry, Bernard Larouzé Evaluation of visual outcome of cataract surgery in an Indian eye camp Harpreet Kapoor, Arin Chatterjee, Richard Daniel, Allen Foster Topographic anatomy of the eyelids, and the effects of sex and age Willem A van den Bosch, Ineke Leenders, Paul Mulder Measurement of retinal nerve fibre layer by scanning laser polarimetry and high pass resolution perimetry in normal tension glaucoma with relatively high or low intraocular pressure Motohiro Shirakashi, Shigeo Funaki, Haruko Funaki, Kiyoshi Yaoeda, Haruki Abe LABORATORY SCIENCE Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopatho- logical study SH Sarks,¥ #A rnold, M C Killingsworth, ¥ P Sarks Perspective Should diabetic patients be screened for glaucoma? John D Ellis, Andrew D Morris, Caroline ¥M acEwen for the DARTS/MEMO Collaboration Letters to the editor Correspondence Book reviews Notices Correction Instructions for authors No 4 APRIL 1999 Editorials The BO goes full text on the web; www.bjophthalmol.com John V Forrester Much more than water 7 Daniel Nelson Trends in vitreoretinal surgery—time to stop and think Peter K Leaver Commentary Measuring the burden of childhood blindness % S Rahi, C E Gilbert, A Foster, D Minassian Newsdesk Original articles CLINICAL SCIENCE Treatment of dry eye by autologous serum application in Sjégren’s syndrome Kazuo Tsubota, Eiki Goto, Hiromi Fujita, Masafumi Ono, Hiroko Inoue, Ichiro Saito, Shigeto Shimmura Trends in vitreoretinal surgery at a tertiary referral centre: 1987 to 1996 F G Ah-Fat, M C Sharma, M A Majid, IN McGalliard, D Wong Amniotic membrane transplantation for ocular surface reconstruction Augusto Azuara-Blanco, C TP illai, Harminder S Dua Proposed classification for topographic patterns seen after penetrating keratoplasty Constantinos H Karabatsas, Stuart D Cook, John M Sparrow Haemophilus influenzae associated scleritis Scott O Sykes, Christopher Riemann, Carmen I Santos, David M Meisler, Careen Y Lowder, John P Whitcher, Emmett T Cunningham Fr Allo-limbal transplantation in patients with limbal stem cell deficiency Harminder S Dua, Augusto Azuara-Blanco Assessment of macular function by multifocal electroretinogram before and after macular hole surgery Ying-Fie Si, Shoji Kishi, Koji Aoyagi Dopamine use is an indicator for the development of threshold retinopathy of prematurity Michael B Mizoguchi, Thomas G Chu, Frederick M Murphy, Neil Willits, Lawrence S Morse Indocyanine green angiographic features prognostic of visual outcome in the natural course of patients with age related macular degeneration Akira Obana, Yuko Gohto, Muneaki Matsumoto, Tokuhiko Miki, Kazuteru Nishiguti OCT imaging of choroidal neovascularisation and its role in the determination of patients’ eligibility for surgery A Giovannini, G P Amato, C Mariotti, B Scassellati-Sforzolini Endoscopic laser recanalisation of presaccal canalicular obstruction Andreas Kuchar, Philipp Novak, Stefan Pieh, Marcus Fink, Franz Josef Steinkogler Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma Marc D de Smet, Virginia Stark Vancs, David Kohler, Diane Solomon, Chi Chao Chan Lens epithelial changes and mutated gene expression in patients with myotonic dystrophy Toshiaki Abe, Masami Sato, Junko Kuboki, Tetsuya Kano, Makoto Tamai The triple procedure: in the bag placement versus ciliary sulcus placement of the intraocular lens Vincent M Borderie, Olivier Touzeau, Tristan Bourcier, Santos Carvajal-Gonzalez, Laurent Laroche Diabetes mc!litus: a risk factor in patients with Graves’ orbitopathy Rachel Kalmann, Maarten Ph Mourits Peripapillary retinal blood flow in normal tension glaucoma Hak Sung Chung, Alon Harris, Larry Kagemann, Bruce Martin Ophthalmic and visual profile of guide dog owners in Scotland K Refson, A ¥ Jackson, A E Dusoir, D B Archer LABORATORY SCIENCE Modulating phenotype and cytokine production of leucocytic retinal infiltrate in experimental autoimmune uveoretinitis following intranasal tolerance induction with retinal antigens Barbara Laliotou, Andrew D Dick Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathy Gillian Smith, David McLeod, David Foreman, Mike Boulton Perspective Head mounted video magnification devices for low vision rehabilitation: a comparison with existing technology Robert Harper, Louise Culham, Christine Dickinson Letters to the editor In memoriam Book reviews Notices Instructions for authors No 5 MAY 1999 Editorials Brain injury and ocular motor abnormalities in surviving preterm infants Anthony T Moore Criteria for cataract surgery: the role of visual acuity and visual function Andrew F Smith Commentary Ophthalmic medical assistants: response Alistair Fielder, Helen Pointer, Chris Timms Newsdesk Original articles CLINICAL SCIENCE Risk factors for strabismus in children born before 32 weeks’ gestation Philippa M Pennefather, Michael P Clarke, Nicholas P Strong, David G Cottrell, Jonathan Dutton, Win Tin Measuring visual symptoms in British cataract patients: the cataract symptom scale H L Crabtree, A } Hildreth, J E O'Connell, P S Phelan, D Allen, C S Gray Randomised clinical trial of lensectomy versus lens aspiration and primary capsulotomy for children with bilateral cataract in south India Michael Eckstein, P Vijayalakshmi, Clare Gilbert, Allen Foster Traumatic wound rupture after penetrating keratoplasty in Africa RC Bowman, D Yorston, T C Aitchison, B McIntyre, C M Kirkness Aetiological study of the presumed ocular histoplasmosis syndrome in the Netherlands 7 V Ongkosuwito, L M Kortbeek, A Van der Lelij, E Molicka, A Kijlstra, M D de Smet, M S A Suttorp-Schulten Treatment of immune recovery vitritis with local steroids Hugo W A Henderson, Suzanne M Mitchell Patients’ perception of visual impairment in glaucoma: a pilot study Patricia Nelson, Peter Aspinall, Colm O’Brien Pilocarpine induces an increase in the anterior chamber angular width in eyes with narrow angles Hiroshi Kobayashi, Kaori Kobayashi, Funichii Kiryu, Takehisa Kondo Ultrasound biomicroscopic measurement of development of anterior chamber angle Hiroshi Kobayashi, Hisako Ono, Junichii Kiryu, Kaori Kobayashi, Takehisa Kondo Natural history of diabetic macular streak exudates: evidence from a screening programme H L Cook, R Newsom, V Long, S A Smith, JS Shilling, M R Stanford Effect of aging on optic nerve appearance: a longitudinal study Frank ¥ Moya, Luca Brigatti, Joseph Caprioli Estimation of the retinal nerve fibre layer thickness in the papillomacular area of long standing stage IV macular holes Alex Assi, Patrick Watts, James McAllister Smoking as an aetiological factor in a pedigree with Leber’s hereditary optic neuropathy Kailenn Tsao, Phil A Aitken, Donald R Johns Natural history of amblyopia untreated owing to lack of compliance Kurt Simons, Mark Preslan Modelling uveal melanoma Alexander 7 E Foss, lan A Cree, Paul ¥ Dolin, John L Hungerford Incidence of eyelid cancers in Singapore from 1968 to 1995 Sao-Bing Lee, Seang-Mei Saw, Kah-Guan Au Eong, Tat-Keong Chan, Hin-Peng Lee LABORATORY SCIENCE Dendritic cells and macrophages in the uveal tract of the normal mouse eye Paul G McMenamin Significance of serum antibodies reactive with flavoprotein subunit of succinate dehydrogenase in thyroid associated orbitopathy Banu M Hosal, Fil K Swanson, Charlotte R Thompson, Sumihisa Kubota, Kazuaki Gunji, John S Kennerdell, Jack R Wall Analysis of glycosaminoglycans in rabbit cornea after excimer laser keratectomy Takuji Kato, Kiyoo Nakayasu, Kazuyuki Ikegami, Takeo Obara, Toshiji Kanayama, Atsushi Kanai ATP binding cassette transporter retina genotypes and age related macular degeneration: an analysis on exudative non-familial Japanese patients Sachiko Kuroiwa, Hidenobu Kojima, Takanobu Kikuchi, Nagahisa Yoshimura Correlation of histological findings with gadolinium enhanced MRI scans during healing of a PHEMA orbital implant in rabbits Celia R Hicks, lan T Morris, Sarojini Vijayasekaran, Michael } Fallon, Jordana McAllister, Anthony B Clayton, Traian V Chirila, Geoffrey 3C rawford, lan ¥ Constable Perspective Diagnosis of viral and chlamydial keratoconjunctivitis: which laboratory test? Elfath M Elnifro, Robert ¥C ooper, Paul E Klapper, Andrew S Bailey, Andrew B Tullo Letters to the editor Correspondence Notices Instructions for authors No 6 JUNE 1999 Editorials Bias: adding to the uncertainty John M Sparrow, John R Thompson Science! Why should the clinician care? Amanda 3 Churchill Commentary Posterior capsular opacification prevention: IOL design and material Andrew Coombes, Helen Seward Newsdesk Original articles CLINICAL SCIENCE Bias due to incomplete follow up in a cohort study PM Pennefather, W Tin, M P Clarke, ¥D utton, S Fritz, E N Hey Radiotherapy for isolated occult subfoveal neovascularisation in age related macular degeneration: a pilot study Guy Donati, Dominique Soubrane, Maddalena Quaranta, Gabriel Coscas, Gisele Soubrane Cytomegalovirus retinitis after the initiation of highly active antiretroviral therapy: a 2 year prospective study Suzanne M Mitchell, William L Membrey, Michael S Youle, Adanna Obi, Simon Worrell, Brian G Gazzard Image quality in polypseudophakia for extremely short eyes CC Hull,C S C Liu, A Sciscio Inter- and intraobserver variation in the analysis of optic disc images: comparison of the Heidelberg retina tomo- graph and computer assisted planimetry D F Garway-Heath, D Poinoosawmy, G Wollstein, A Viswanathan, D Kamal, L Fontana, R A Hitchings Chronic cortical visual impairment in children: aetiology, prognosis, and associated neurological deficits Richard Huo, Susan K Burden, Creig S Hoyt, William V Good Preschool vision screening: negative predictive value for amblyopia Douglas K Newman, Miranda M East Ocular ochronosis in alkaptonuria patients carrying mutations in the homogentisate 1,2-dioxygenase gene Ute Felbor, Yvonne Mutsch, Franz Grehn, Clemens R Miiller, Wolfram Kress Decreased tear lactoferrin concentration in patients with chronic hepatitis C Tohru Abe, Ako Nakajima, Mutsumi Matsunaga, Shozo Sakuragi, Masafumi Komatsu Ocular signs and symptoms and vitamin A status in patients with cystic fibrosis treated with daily vitamin A supplements Ejaz A Ansari, Kamal Sahni, Christine Etherington, Alison Morton, Steven P Conway, Eduardo Moya, James M Littlewood Treatment of obstructive epiphora in adults by balloon dacryocystoplasty Zeynep Yazici, Bulent Yazict, Mufit Parlak, Haluk Erturk, Gursel Savei Confocal microscopy in the iridocorneal endothelial syndrome Auguste G-Y Chiou, Stephen C Kaufman, Roger W Beuerman, Toshihiko Ohta, Volkan Yaylali, Herbert E Kaufman Iris crystals in chronic uveitis Andrew B Callear, Anita Reynolds, John Harry, Philip I Murray The Bristol Shared Care Glaucoma Study: reliability of community optometric and hospital eye service test measures PG D Spry, IC Spencer, JM Sparrow, T F Peters, S T Brookes, S Gray, I Baker, JE Furber, D L Easty Effect of diode laser trans-scleral cyclophotocoagulation in the management of glaucoma after intravitreal silicone oil injection for complicated retinal detachments Soo Kyung Han, Ki Ho Park, Dong Myung Kim, Bong Leen Chang Selective laser trabeculoplasty v argon laser trabeculoplasty: a prospective randomised clinical trial Karim F Damyi, Kirtida C Shah, William ¥ Rock, Harkaran S Bains, William G Hodge LABORATORY SCIENCE PAX6 expression in the developing human eye Sachiko Nishina, Shinichi Kohsaka, Yuki Yamaguchi, Hiroshi Handa, Atsushi Kawakami, Hajime Fujisawa, Noriyuki Azuma Growth factor staining patterns in the pig retina following retinal laser photocoagulation Ming Xiao, David McLeod, John Cranley, Gillian Williams, Mike Boulton Antimicrobial defensin peptides of the human ocular surface Richard John Haynes, Patrick Jason Tighe, Harminder Singh Dua Ocular adnexal lymphoma—comparison of MALT lymphoma with other histological types Mark Cahill, Colma Barnes, Paul Moriarty, Peter Daly, Susan Kennedy Perspective Amniotic membrane transplantation Harminder S Dua, Augusto Azuara-Blanco Letters to the editor Mailbox Book review Notices Instructions for authors No 7 JULY 1999 Editorial A role for hepatocyte growth factor in diabetic retinopathy? Mike Boulton Commentary Writing to our patients G Jayakrishna Menon, Gordon N Dutton Newsdesk Original articles CLINICAL SCIENCE New treatment of dry eye: the effect of calcium ointment through eyelid skin delivery Kazuo Tsubota, Yu Monden, Yukiko Yagi, Eiki Goto, Shigeto Shimmura Identification and antibiotic susceptibility of coagulase negative staphylococci isolated in corneal/external infections Antonio Pinna, Stefania Zanetti, Mario Sotgiu, Leonardo A Sechi, Giovanni Fadda, Francesco Carta Evaluation of corneal thickness and topography in normal eyes using the Orbscan corneal topography system Zuguo Liu, Andrew ¥ Huang, Stephen C Pflugfelder Topographic and keratometric astigmatism up to 1 year following small flap trabeculectomy (microtrabeculectomy) SA Vernon, H } Zambarakji, F Potgieter, ¥E vans, P B Chelil Early retreatment of infantile esotropia: comparison of reoperation and botulinum toxin aime Tejedor, José M Rodriguez Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery Jeong-Min Hwang, Bong Leen Chang Creation and testing of a practical visual function assessment for use in Africa: correlation with visual acuity, contrast sensitivity, and near vision in Malawian adults Karin van Dijk, Susan Lewallen, Moses Chirambo, Jane Gardiner, Brian Hoar, Janette Lindley, N Kevin Wade, Paul Courtright Visual performance in giant cell arteritis (temporal arteritis) after 1 year of therapy Mark ¥ Kupersmith, Regina Langer, Hal Mitnick, Robert Spiera, Harry Spiera, Marjorie Richmond, Stephen Paget Clinical and genetic heterogeneity in autosomal dominant cataract Alexander Ionides, Peter Francis, Vanita Berry, Donna Mackay, Shomi Bhattacharya, Alan Shiels, Anthony Moore Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change David W Evans, Alon Harris, Melanie Garrett, Hak Sung Chung, Larry Kagemann Risk factors for failures of trabeculectomies performed without antimetabolites Holger Mietz, Birgit Raschka, Giinter K Krieglstein Subtraction ICG angiography in Harada’s disease Takeya Kohno, Tokuhiko Miki, Kunihiko Shiraki, Kiyoshi Kano, Michiko Matsushita, Kazuhiko Hayashi, Jean Jacques De Laey LABORATORY SCIENCE Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus Kei Shinoda, Susumu Ishida, Shinichi Kawashima, Toshiko Wakabayashi, Tadayuki Matsuzaki, Michiyo Takayama, Ken Shinmura, Masakazu Yamada Angiogenic factors in human proliferative sickle cell retinopathy Fingtai Cao, Michaela Kunz Mathews, D Scott McLeod, Carol Merges, Leonard M Hijelmeland, Gerard A Lutty Soluble ICAM-1 serum levels in patients with intermediate uveitis Anne-Marie Klok, Leny Luyendijk, Michel 7 W Zaal, Aniki Rothova, Aize Kilstra Dynamics of phosphorothioate oligonucleotides in normal and laser photocoagulated retina Wéei-Yong Shen, Kerryn L Garrett, Lyndon da Cruz, lan } Constable, Piroska E Rakocz Morphological variations of the peripapillary circle of Zinn—Haller by flat section Myung-Kyoo Ko, Dong-Seob Kim, Yoon-Koo Ahn Perspective Macular pigment and age related macular degeneration S Beatty, M Boulton, D Henson, H-H Koh, I ¥ Murray Letters to the editor Mailbox Book reviews Notices No 8 AUGUST 1999 Page Editorials 889 Cataract surgery—quantity and quality Richard Wormald 890 Wellcome Trust support for vision research John R Stephenson 892 Newsdesk Original articles CLINCAL SCIENCE Profile of patients presenting for cataract surgery in the UK: national data collection Parul Desai, Angela Reidy, Darwin C Minassian Audit of extracapsular cataract extraction and posterior chamber lens implantation as a routine treatment for age related cataract in east Africa David Yorston, Allen Foster Automated localisation of the optic disc, fovea, and retinal blood vessels from digital colour fundus images Chanyira Sinthanayothin, James F Boyce, Helen L Cook, Thomas H Williamson Effect of software manipulation (Photcshop) of digitised retinal images on the grading of diabetic retinopathy L D George, ¥L usty, D R Owens, R L Ollerton Phenotypic variations in a family with retinal dystrophy as result of different mutations in the ABCR gene B Jeroen Klevering, Marc van Driel, Dorien ¥ R van de Pol, Alfred }L G Pinckers, Frans P M Cremers, Carel B Hoyng Phenotype of autosomal recessive congenital microphthalmia mapping to chromosome 14q32 David A R Bessant, Khalid Anwar, Shagufta Khaliq, Abdul Hameed, M Ismail, Annette M Payne, S Qasim Mehdi, Shomi S Bhattacharya Long term results of radiotherapy for subfoveal choroidal neovascularisation in age related macular degeneration Martine Mauget-Faysse, Christophe Chiquet, Dan Milea, Pascale Romestaing, Jean-Pierre Gérard, Philippe Martin, Frangotse Koenig Causes of childhood blindness in the People’s Republic of China: results from 1131 blind school students in 18 provinces S ¥ Hornby, Y Xiao, C E Gilbert, A Foster, X Wang, X Liang, H Fing, L Wang, W Min, Y Shi, Y Li Eye injuries in children: the current picture Caroline }M acEwen, Paul S Baines, Parul Desai Population based assessment of diabetic retinopathy in an urban population in southern India Lalit Dandona, Rakhi Dandona, Thomas J Naduvilath, Catherine A McCarty, Gullapalli N Rao Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7 M McKibbin, F D Isaacs, A J Morrell Prophylactic scleral buckle for prevention of retinal detachment following vitrectomy for macular hole Tom S Chang, Ed McGill, Dawn A Hay, William H Ross, Alan L Maberley, Lyn M Sibley, Patrick E Ma, Michael F Potter Endoscopy of the lacrimal system Klaus Miillner, Elisabeth Bodner, Geva E Mannor LABORATORY SCIENCE Vitreous levels of intercellular adhesion molecule 1 (ICAM-1) as a risk indicator of proliferative vitreoretinopathy G Astrid Limb, Anthony H Chignell Detection of herpes simplex virus DNA in atypical epithelial keratitis using polymerase chain reaction Noriko Koizumi, Kohjt Nishida, Wakako Adachi, Mamoru Tei, Yoichi Honma, Atsuyoshi Dota, Chie Sotozono, Norithiko Yokoi, Shuji Yamamoto, Shigeru Kinoshita Effect of the cytostatic agent idarubicin on fibroblasts of the human Tenon’s capsule compared with mitomycin C Claudia Heilmann, Peter Schénfeld, Thomas Schliiter, Ralf Bohnensack, Wolfgang Behrens-Baumann New animal model for human ocular toxocariasis: ophthalmoscopic observation Tomoko Hara Takayanagi, Nobuaki Akao, Ryoko Suzuki, Misato Tomoda, Setsuko Tsukidate, Koichiro Fujita Suppression of induction of experimental immune mediated blepharoconjunctivitis by tolerogenic conjugates of the antigen and monomethoxypolyethylene glycol Atsuki Fukushima, Koji Nishino, Hironori Yoshida, Masaru Takata, Hisayuki Ueno Perspective Ganglion cell death in glaucoma: what do we really know? Neville N Osborne, John PM Wood, Glyn Chidlow, Fi-Hong Bae, José Melena, Mark S Nash Letters to the editor Mailbox Book reviews Notices Instructions for authors No 9 SEPTEMBER 1999 Page Editorial 999 The well tempered crystal ball in normal tension glaucoma Stephen A Vernon 1001 Newsdesk Original articles CLINICAL SCIENCE Clinical factors influencing the visual prognosis of the fellow eyes of normal tension glaucoma patients with unilateral field loss Luigi Fontana, Rodolfo Armas, David F Garway-Heath, Catey V Bunce, Darmalingum Poi ry, Roger A Hitchings Is a tight patch necessary after trabeculectomy? G E Trope, Y M Buys, 7F lanagan, L Wang “Orientation teeth” in non-mechanical laser corneal trephination for penetrating keratoplasty: 2.94 um Er:YAG v 193 nm ArF excimer laser Ashley Behrens, Berthold Seitz, Michael Kiichle, Achim Langenbucher, Murat M Kus, Carmen Rummelt, Gottfried O H Naumann LASIK for post penetrating keratoplasty astigmatism and myopia Suzanne K Webber, Michael A Lawless, Gerard L Sutton, Christopher M Rogers Microbial decontamination of human donor eyes with povidone-iodine: penetration, toxicity, and effectiveness E Pels,G F 7 M Vrensen Risk factors for treatment outcome of suspected microbial keratitis Nigel Morlet, Darwin Minassian, Jeremy Butcher, and the Ofloxacin Study Group Comparison of dacryocystography and lacrimal scintigraphy in the diagnosis of functional nasolacrimal duct obstruction Michael J Wearne, John Pitts, John Frank, Geoffrey E Rose Visual outcome after phacoemulsification and IOL implantation in diabetic patients Anna Zaczek, Géran Olivestedt, Charlotta Zetterstrém Diabetic versus non-diabetic colour vision after cataract surgery Line Kessel, Anita Alsing, Michael Larsen Treatment of retinal tears and lattice degenerations in fellow eyes in high risk patients suffering retinal detachment: a prospective study Leonardo Mastropasqua, Paolo Carpineto, Marco Ciancaglini, Gennaro Falconio, Pier E Gallenga Intravitreal dexamethasone in exogenous bacterial endophthalmitis: results of a prospective randomised study Taraprasad Das, Subhadra Jalali, Vijaya K Gothwal, Savitri Sharma, Thomas ¥ Naduvilath Effect of panretinal photocoagulation on serum levels of laminin in patients with diabetes: a prospective study L Luis Masmiquel, Rosa Burgos, Carlos Mateo, Ramon Marti, Rosa M Segura, Rafael Simo Everting suture correction of lower lid involutional entropion Mark Wright, Dugald Bell, Chris Scott, Brian Leatherbarrow LABORATORY SCIENCE Concentration dependent effects of hydrogen peroxide on lens epithelial cells Nobuyuki Ohguro, Masakatsu Fukuda, Tetsuo Sasabe, Yasuo Tano a/B— and y/6 TCR+ lymphocyte infiltration in necrotising choroidal melanomas AlexanderA Bialasiewicz, Fin- Xue Ma, Gisbert Richard IL-4 regulates chemokine production induced by TNF-a in keratocytes and corneal epithelial cells Yoji Takano, Kazumi Fukag Shigeto Shi ‘a, Kazuo Tsubota, Yoshihisa Oguchi, Hirohisa Saito Culture and characterisation of epithelial cells from human pterygia Nick Di Girolamo, Nicodemus Tedla, Rakesh K Kumar, Peter McCluskey, Andrew Lloyd, Minas T Coroneo, Denis Wakefield Perspective Hypertension and diabetic retinopathy—what’s the story? ¥ T Gillow, ¥M Gibson, P M Dodson Letters to the editor Mailbox Book reviews Notices Instructions for authors No 10 OCTOBER 1999 Page Editorial 1101 Penetrating injury of the eye Paul McCormack Commentary 1103 Photocoagulation of subfoveal choroidal neovascular membranes in age related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland S Beatty, K G Au Eong, D McLeod, P N Bishop Newsdesk Original articles CLINICAL SCIENCE Simulation model of an eyeball based on finite element analysis on a supercomputer Etichi Uchio, Shigeaki Ohno, Foju Kudoh, Koki Aoki, Lech Tomasz Kisielewicz Amblyopia and visual acuity in children with Down’s syndrome William G Tsiaras, Sigfried Pueschel, Charles Keller, Robert Curran, Stephan Giesswein A vision specific functional index for use in patients with age related macular degeneration PM Hart, U Chakravarthy, M R Stevenson, ¥ Q Famison Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome Patrick I Condon, Charles G McEwen, Mark Wright, Graeme Mackintosh, Robin ¥ Prescott, Carolyn McDonald Dry eye after haematopoietic stem cell transplantation Yoko Ogawa, Shinichiro Okamoto, Masatoshi Wakui, Reiko Watanabe, Masakazu Yamada, Mami Yoshino, Masafumi Ono, Hao-Yung Yang, Yukihiko Mashima, Yoshihisa Oguchi, Yasuo Ikeda, Kazuo Tsubota New equipment to prevent carbon dioxide rebreathing during eye surgery under retrobulbar anaesthesia A Schlager, Hubert Staud Retained intravitreal lens fragments after phacoemulsification: a clinicopathological correlation LM W Yeo, D G Charteris, C Bunce, P ¥ Luthert, Z ¥ Gregor Choroidal folds and papilloedema Lorraine M Cassidy, Michael D Saunders Difference between RP2 and RP3 phenotypes in X linked retinitis pigmentosa Christina J Flaxel, Marcelle fay, Dawn L Thiselton, Mani Nayudu, Alison J Hardcastle, Alan Wright, Alan C Bird Ocular manifestations in children and adolescents with Lyme arthritis Hans-Iko Huppertz, Doris Miinchmeier, Wolfgang Lieb Anterior uveitis associated with intravenous’ cidofovir use in patients with cytomegalovirus retinitis Jayakrishna Ambati, Kevin B Wynne, Mary C Angerame, Michael R Robinson Grading nuclear cataract: reproducibility and validity of anew method Nigel F Hall, Philip Lempert, Rosaleen P Shier, Rahila Zakir, David Phillips Laser pointers revisited: a survey of 14 patients attending casualty at the Bristol Eye Hospital C S Sethi, R HB Grey, C Dean Hart LABORATORY SCIENCE Cell and protein adhesion studies in glaucoma drainage device development The AGFID project team Effect of trephination technique on the ultrastructure of corneal transplants: guided trephine system v posterior punch technique W Radner, Ch Skorpik, R Loewe, C Mudrich,G Radner, R Mallinger Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies Kohji Nishida, Andrew ¥ Quantock, Atsuyoshi Dota, Nam-Ho Choi-Miura, Shigeru Kinoshita Scientific correspondence Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid Osman Cekig, Cosar Batman, Umit Yasar, Yiiksel Totan, Nursabah E Basci, Atilla Bozkurt, Orhan Zilelioglu, S Oguz Kayaalp Influence of highly active antiretroviral therapy on the development of CMV disease in HIV positive patients at high risk for CMV disease Frank D Verbraak, René Boom, Pauline M E Wertheim-van Dillen, Gerardus ¥ van den Horn, Aize Kijlstra, Marc D de Smet Perspective Risk factors for intraocular melanoma and occupational exposure Jean-Michel Lutz, lan A Cree, Alex } Foss Letters to the editor Mailbox Book reviews Notices Instructions for authors No 11 NOVEMBER 1999 Editorial Impact of new technologies in ophthalmology John V Forrester Commentary Transpupillary thermotherapy of choroidal melanoma with or without brachytherapy: a dilemma J E E Keunen, F G Fournéwe-de Korver,J A Oosterhuis Newsdesk Perspectives Ophthalmology in the post-genomic era GC M Black, M E Boulton, P N Bishop, D McLeod Molecular therapy in ocular wound healing M Francesca Cordeiro, Gregory S Schultz, Robin R Ali, Shomi S Bhattacharya, Peng T Khaw New developments in sustained release drug delivery for the treatment of intraocular disease Gisela Vélez, Scott M Whitcup Immunomodulation of autoimmune responses with monoclonal antibodies and immunoadhesins: treatment of ocular inflammatory disease in the next millennium Andrew D Dick, John D Isaacs Closer to nature: new biomaterials and tissue engineering in ophthalmology Bruce Allan Laser imaging of the retina PF Sharp, AM anivannan, P Vieira, ¥H Hipwell New applications in ultrasound technology H R Atta Scanning laser ophthalmoscopy and fundus fluorescent leucocyte angiography Parwez Hossain Telemedicine Jan Murdoch Refractive surgery Peter ¥M cDonnell Eradication of trachoma worldwide David Mabey, Robin Bailey Information technology in ophthalmology—experience with an electronic patient record G W Aylward, D N Parmar Original articles CLINICAL SCIENCE Mycophenolate mofetil versus cyclosporin A in high risk keratoplasty patients: a prospectively randomised clinical trial Alexander Reis, Thomas Reinhard, Adina Voiculescu, Bernd Kutkuhn, Erhard Godehardt, Helga Spelsberg, Christoph Althaus, Rainer Sundmacher Outcome of cataract surgery considering the preoperative situation: a study of possible predictors of the functional outcome Mats Lundstrim, Ulf Stenevi, William Thorburn Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients Jeroen van Root, Sicco G W S thoe Schwartzenberg, Paul G H Mulder, Seerp G Baarsma Measuring colour rivalry suppression in amblyopia Timothy S Hofeldt, Albert ¥H ofeldt LABORATORY SCIENCE Hyperhomocysteinaemia in young patients with non-arteritic anterior ischaemic optic neuropathy Aki Kawasaki, Valerie A Purvin, Richard A Burgett Localised retinal nerve fibre layer defects in chronic experimental high pressure glaucoma in rhesus monkeys Jost B Jonas, Sohan Singh Hayreh Scientific correspondence Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse tran- scription polymerase chain reaction JA El-Ghrably, Harminder S Dua, Gavin M Orr, David Fischer, Patrick } Tighe Rhinostomies: an open and shut case? Chris ¥ McLean, lan A Cree, Geoffrey E Rose Corneal wound healing following laser in situ keratomileusis (LASIK): a histop. ological study in rabbits Takuji Kato, Kivoo Nakayasu, Yuji Hosoda, Yasuo Watanabe, Atsushi Kanai Letters to the editor Mailbox Notices Correction Instructions for authors No 12 DECEMBER 1999 Editorial Importance of early diagnosis of retinoblastoma Jerry A Shields Commentary Advancing microsurgical instrumentation into the 21st century A Waldock, T A Waldock Newsdesk Original articles CLINICAL SCIENCE Delay in diagnosis of retinoblastoma: risk factors and treatment outcome Andrea G Goddard, Judith E Kingston, John L Hungerford Ocular arterial blood flow of choroidal melanoma eyes before and after stereotactic radiotherapy using Leksell gamma knife: 2 year follow up Pia V Vécsei, Karl Kircher, Gunda Nagel, Sabine Toma-Bstaendig, Irene Ruhswurm, Michael Georgopoulos, Martin Zehetmayer Perifoveal microcirculation in eyes with epiretinal membranes Kazuaki Kadonosono, Northiko Itoh, Etichi Nomura, Shigeaki Ohno Alterations in the conjunctival bacterial flora following a single dose of azithromycin in a trachoma endemic area Kenneth C Chern, S K Shrestha, Vicky Cevallos, H L Dhami, Pawan Tiwari, Laurie Chern, John P Whitcher, Tho- mas M Lietman National cataract surgery survey 1997-8: a report of the results of the clinical outcomes Parul Desai, DC Minassian, Angela Reidy Full text reading with a central scotoma: pseudo regressions and pseudo line losses Avinoam B Safran, Flor- ence Duret, Marc Issenhuth, Christophe Mermoud Randomised controlled trial of corticosteroid regimens in endothelial corneal allograft rejection 7 Hudde, DC Minassian, D F P Larkin LABORATORY SCIENCE Cellular photoablation to control postoperative fibrosis in a rabbit model of filtration surgery Salvatore Grisanti, Michael Diestelhorst, Klaus Heimann, Giinter Krieglstein Soluble Fas and Fas ligand in human tear fluid after photorefractive keratectomy I/po Tuominen, Minna Vesali Anna-Maija Teppo, Carola Grénhagen-Riska, Timo Tervo Cell subpopulations in failed human corneal grafts Lucia Kuffova, Vladimir Holan, Lynne Lumsden, John V Forrester, Martin Filipec Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine Klaus Trier, Elith Bjarne Olsen, Takasi Kobayashi, Seren Munk Ribel-Madsen Role of ocular matrix metalloproteinases in peripheral ulcerative keratitis VA Smith, H B Hoh, D L Easty Scientific correspondence Environmental scanning electron microscopic study of macrophages associated with the tunica vasculosa lentis in the developing rat eye 7% Djano, B Griffin, I van Bruggen, PG McMenamin CD56+ T cells in the peripheral blood of uveitis patients Hitoshi Yato, Yoshihiro Matsumoto Ocular complications of acoustic neuroma surgery M G Mulhern, P M Aduriz-Lorenzo, D Rawluk, L Viani, P Eustace, P Logan The pituitary-adrenal axis in idiopathic retinal vasculitis H E Palmer, M R Stanford, C Lowy, M F Wheeler, G R Wallace, EM Graham Perspective Acquired colour vision defects in glaucoma—their detection and clinical significance Mireia Pacheco-Cutillas, Arash Sahraie, David F Edgar Letters to the editor Mailbox Book reviews Notices Author index Subject index Contents

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