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British Journal of Obstetrics and Gynaecology Edited by John M. Grant Volume 104, 1997 © Royal College of Obstetricians and Gynaecologists 1997 British Journal of Obstetrics and Gynaecology 27 Sussex Place Regent’s Park London NW1 4RG Published by Blackwell Science Osney Mead Oxford OX2 OEL All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the copyright owner. Authorisation to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Blackwell Scientific Publications for libraries and other users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the base fee of $14.00 per copy is paid directly to CCC, 222 Rosewood Drive, Suite 910 Danvers, MA 01923, USA. 0306- 5456/97$14.00. (For copying beyond that permitted by section 107 or 108 of the US Copyright law.) This content does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Special requests should be addressed to the Editor. Printed in Great Britain by Cambridge University Press, Cambridge, UK Contents Are sociodemographic factors predictive of preterm birth? A reappraisal of the 1958 British Perinatal Mortality Survey Volume 104 Number 1 January 1997 H. I. J. Wildschut, T. Nas & J. Golding EDITOR’S CHOICE GYNAECOLOGY COMMENTARY A double-blind randomised controlled trial of the effects of medroxyprogesterone acetate on bone density of women Hormone replacement therapy in women with liver disease taking oestrogen replacement therapy J. O’Donohue & R. Williams J. D. Adachi, E. J. Sargeant, M. A. Sagle, D. Lamont, P. D. Fawcett, W. G. Bensen, M. McQueen, REVIEW D. J. Nazir & C. H. Goldsmith The management of late fetal death: a guide to comprehensive care 4 Laparoscopic sterilisation: opinion and practice among gynaecologists in Scotland R. Fox, M. Pillai, H. Porter & G. Gill G. C. Penney, V. Souter, A. Glasier & A. A. Templeton MATERNAL-—FETAL MEDICINE Serum levels of the tumour-associated trypsin inhibitor in Combining nuchal translucency with umbilical Doppler patients with endometriosis velocimetry for detecting fetal trisomies in the first M. Medl, E. Ogris, C. Peters-Engl, M. Mierau, trimester of pregnancy P. Buxbaum & S. Leodolter J. M. Martinez, A. Borrell, E. Antolin, B. Puerto, E. Casals, Posterior colporrhaphy: its effects on bowel and sexual function J. Ojuel & A. Fortuny M. A. Kahn & S. L. Stanton Fetal Rhesus D genotyping on amniocytes in alloimmunised pregnancies using fluorescence duplex polymerase chain reaction Urogenital ageing and its effect on sexual health in older British women G. Crombach, F- Picard, M. Beckmann, B. Tutschek, D. H. Barlow, L. D. Cardozo, R. M. Francis, M. Griffin, R. Bald & D. Niederacher D. M. Hart, E. Stephens & D. W. Sturdee Maternal and fetal levels of methionine and homocysteine in Reversal of sterilisation by the railroad technique early human pregnancy L. C. Edozien, D. Anastassopulos & A. M. Mander R. P. M. Steegers-Theunissen, N. C. Wathen, T. K. A. B. Eskes, B. van Raaij-Selten & T. Chard UROGYNAECOLOGY OBSTETRICS GAX collagen in the treatment of urinary incontinence in The intrapartum CTG prior to neonatal encephalopathy at term: a elderly women: a two year follow up case-control study V. Khullar, L. D. Cardozo, D. Abbott & K. Anders J. A. D. Spencer, N. Badawi, P. Burton, J. Keogh, P. Pemberton & F. Stanley ONCOLOGY Ripening and dilatation of the unfavourable cervix for induction Investigation of 100 consecutive negative cone biopsies of labour by a double balloon device: experience with 250 cases P. Golbang, J. Scurry, S. de Jong, D. McKenzie, J. Atad, M. Hallak, Y. Ben-David, R. Planner, J. Pyman & R. Davoren R. Auslender & H. Abramovici Gestational trophoblastic disease with liver metastases: Stepwise compared with rapid application of vacuum in the Charing Cross experience ventouse extraction procedures R. A. F- Crawford, E. Newlands, G. J. S. Rustin, F. TH. Lim, J. P. Holm, N. W. E. Schuitemaker, L. Holden, R. A’Hern & K. D. Bagshawe FH. M. Jansen & J. Hermans Local immune response in endometrial carcinomas Preventing Rhesus D haemolytic disease of the newborn by T. Hachisuga, K. Fukuda, S. Nakamura, giving anti-D immunoglobulin: are the guidelines being T. Iwasaka & H. Sugimori adequately followed? H. L. Howard, V. J. Martlew, I. R. McFadyen & C. A. Clarke SHORT COMMUNICATION Counselling implications of chromosomal abnormalities Use of magnesium sulphate in Scottish obstetric units other than trisomy 21 detected through a maternal G. C. S. Smith & H. P. McEwan serum screening programme E. Sheridan, J. Williams, A. Caine, R. Morgan, CASE REPORT G. Mason & R. F: Mueller An unusual case of cystolithiasis: a urological lesson for Faecal incontinence after childbirth gynaecologists C. MacArthur, D. E. Bick & M. R. B. Keighley G. P. Cumming, S. P. Bramwell & D. A. R. Lees EPIDEMIOLOGY CORRESPONDENCE Antecedent circumstances surrounding neural tube defect births The relation between serum markers in the second trimester and in 1990-199] placental pathology. A study on extremely small for gestational age fetuses (Vol 103, August 1996) P. Williamson, E. Alberman, C. Rodeck, M. Fiddler, S. Church & R. Harris J. Kingdom xil CONTENTS Active mismanagement of labour (Vol 103, August 1996) Urodynamics: prediction, outcome and analysis of mechanism for cure of stress incontinence by periurethral collagen J. Stronge & M. Foley A. K. Monga & S. L. Stanton Randomised evaluation of a prototype suction fetal scalp electrode (Vol 103, June 1996) M. Geary GYNAECOLOGY Fetal size at birth in relation to quality of blood glucose control The mythology of hormone replacement therapy in pregnancies complicated by pregestational diabetes mellitus B. W. Hartmann & J. C. Huber (Vol 103, May 1996) R. Kimmerle & W. Klockenbusch OBSTETRICS Birth under water—to breathe or not to breathe Transcutaneous electrical nerve stimulation in labour pain: (Vol 103, March 1996) a systematic review G. J. Hofmeyr, V. C. Nikodem & M. De Jagert D. Carroll, M. Tramer, H. McQuay, B. Nye & A. Moore Differentiation of growth retarded from normally grown fetuses and prediction of intrauterine growth retardation using Doppler Serum screening for Down’s syndrome: how much do health ultrasound (Vol 103, July 1996) professionals know? P. Owen M. Sadler Risk factors and fetal outcome in cases of shoulder dystocia Selection biases invalidate current low birthweight compared with normal deliveries of a similar birthweight weight-for-gestation standards (Vol 103, September 1996) W. Tin, U. K. Wariyar& E. N. Hey M. Geary The relation between fetal abdominal circumference and Is there any value in the long term follow up of women treated birthweight: findings in 3512 pregnancies 186 for endometrial cancer? (Vol 103, July 1996) G. C. S. Smith, M. F. S. Smith, M. B. McNay& J. E. E. Fleming J. R. Allsop, J. Preston & S. Crocker An ultrasound study of gestational and postural changes in the deep venous system of the leg in pregnancy 191 N. S. Macklon, I. A. Greer & A. W. Bowman Volume 104 Number 2 February 1997 The deep venous system in the puerperium: an ultrasound study N. S. Macklon & I. A. Greer EDITOR’S CHOICE Outcome of pregnancy in women with Marfan’s syndrome COMMENTARY K. J. Lipscomb, J. Clayton Smith, B. Clarke, Gynaecological cancer services: time for change P. Donnai & R. Harris H. C. Kitchener A randomised comparison between amniotic fluid index and maximum pool depth in the monitoring of post-term pregnancy REVIEW Z. Alfirevic, M. Luckas, S. A. Walkinshaw, The management of endometrial cancer M. McFarlane & R. Curran F. Lawton MATERNAL-FETAL MEDICINE ONCOLOGY Increased fetal nuchal translucency thickness at 10—14 weeks: Whagghanges in the organisation of cancer services will is screening for maternal—fetal infection necessary? improve the outcome for women with ovarian cancer? N. J. Sebire, D. Bianco, R. J. M. Snijders, C. Woodman, A. Baghdady, S. Collins & J.-A. Clyma M. Zuckerman & K. H. Nicolaides The management of cervical carcinoma within the Management of twin pregnancies discordant for anencephaly South West Region of England N. J. Sebire, W. Sepulveda, K. S. Hughes, S. Jackson, J. Murdoch, K. Howe, C. Bedford, P. Noble & K. H. Nicolaides T. Sanders & A. Prentice Management of twin pregnancies with fetal trisomies A randomised controlled trial evaluating a novel cytotoxic drug delivery system for the treatment of cervical N. J. Sebire, R. J. M. Snijders, C. Santiago, intraepithelial neoplasia G. Papapanagiotou & K. H. Nicolaides H. K. Sidhu, J. H. Price, P. A. McCarron, D. F. McCafferty, Suppression of serum vascular endothelial growth factor A. D. Woolfson, D. Biggart & W. Thompson immunoreactivity in normal pregnancy and in pre-eclampsia Video colpography: a new technique for secondary cervical F. Lyall, I. A. Greer, F: Boswell & R. Fleming screening 150 Association of gestational diabetes with abnormal maternal L. J. Etherington, J. Dunn, M. I. Shafi, T. Smith & D. M. Luesley vascular endothelial function G. A. Knock, A. L. McCarthy, C. Lowy & L. Poston UROGYNAECOLOGY Human placental syncytiotrophoblast microvillous membranes Incontinence in elderly women: is periurethral collagen impair maternal vascular endothelial function 235 an advance? A. P. Cockell, J. G. Learmont, A. K. Smarason, C. W. G. Redman, S. L. Stanton & A. K. Monga I. L. Sargent & L. Poston CONTENTS The role of endogenous nitric oxide synthesis in contractility of REVIEWS term or preterm human myometrium Blood transfusion in obstetrics and gynaecology G. D. Jones & L. Poston A. J. Ekeroma, A. Ansari & G. M. Stirrat Liver function tests in pre-eclampsia: importance of comparison with a reference range derived for normal pregnancy Gynaecological aspects of the levonorgestrel-releasing intrauterine system J. C. Girling, E. Dow & J. H. Smith F- Sturridge & J. Guillebaud Lipid peroxidation in cord blood: the effects of umbilical nuchal cord GYNAECOLOGY C. C. Wang & M. S. Rogers Prevalence and characteristics associated with use of hormone replacement therapy in Britain SHORT COMMUNICATIONS T. Moorhead, P. Hannaford & M. Warskyj The electroencephalogram during normal third trimester Hormone replacement therapy with dydrogesterone and pregnancy and six months postpartum 17b-oestradiol: effects on serum lipoproteins and glucose R. W. M. Keunen, J. H. R. Vliegen, D. A. E. van der Pol, tolerance during 24 month follow up G. Gerretsen & C. J. Stam D. Crook, I. F. Godsland, J. Hull & J. C. Stevenson Is HTLV-1 status another antenatal screening test that we need? Impact of percutaneous oestradiol gels in postmenopausal C. Otigbah, A. Kelly, C. Aitken, J. Norman, hormone replacement therapy on clinical symptoms and D. Jeffries & K. J. Erskine endometrium J.-M. Foidart, A. Béliard, B. Hedon, E. Ochsenbein, CASE REPORTS A.-M. Bernard, C. Bergeron & J.-L. Thomas Perinatal care ofa woman with the prenatal diagnosis ofa The influence of oestrogen replacement on faecal incontinence in massive fetal neck tumour (cervical teratoma) postmenopausal women S. P. O'Callaghan, P. Walker, C. Wake, G. Roy & P. Farrell V. Donnelly, P. R. O'Connell & C. O’Herlihy Laparoscopic excision and marsupialisation of bilateral pelvic Topical anaesthesia for diagnostic hysteroscopy and endometrial lymphocysts following extended hysterectomy and pelvic biopsy in postmenopausal women: a randomised lymphadenectomy for endometrial carcinoma placebo-controlled double-blind study B. G. Molnar, A. L. Magos & P. G. Walker E. Cicinelli, T. Didonna, G. Ambrosi, L. M. Schonauer, G. Fiore & M. G. Matteo Ureteric injury following laparoscopic colposuspension P. Aslan & H. H. Woo Normal findings in vulvar examination and vulvoscopy M. van Beurden, N. van der Vange, A. J. M. de Craen, S. P. Tjong-A-Hung, F- J. W. ten Kate, CORRESPONDENCE J. ter Schegget & F- B. Lammes The impact of maternal age on the cost effectiveness of Down’s syndrome screening (Vol 103, June 1996) ONCOLOGY F. D. J. Dunstan & A. B. J. Nix Is loop excision adequate primary management of adenocarcinoma in situ of the cervix? The need for systematic reviews in the treatment of menstrual disorders—another Cochrane collaborative review group is S. J. Houghton, M. I. Shafi, T. P. Rollason & D. M. Luesley born (Vol 103, June 1996) G. S. McCune POSTNATAL CARE The active mismanagement of labour (Vol 103, August 1996) Sexual function after childbirth:women’s experiences, persistent morbidity and lack of professional recognition T. H. Bloomfield; N. Manassiev C. M. A. Glazener Head-to-cervix force: an important physiological variable in labour (Vol 103, August 1996) OBSTETRICS N. Manassiev Use of oral misoprostol in the prevention of postpartum Correspondence. Magnesium sulphate: the time for reckoning haemorrhage (Vol 103, August 1996) H. El-Refaey, P. O'Brien, W. Morafa, J. Walder & C. Rodeck M. F- M. James Randomised trial comparing a policy of early with selective amniotomy in uncomplicated labour at term Clinical and ultrasound prediction of macrosomia in diabetic pregnancies (Vol 103, August 1996) N. Johnson, R. Lilford, K. Guthrie, J. Thornton, M. Barker & M. Kelly W. C. Yoong Antenatal serum screening for genital herpes: a study of knowledge and attitudes of women at a central London hospital Volume 104 Number3 March 1997 B. Vonau, N. Low-Beer, S. E. Barton & J. R. Smith EDITOR’S CHOICE MATERNAL-FETAL MEDICINE COMMENTARY Accuracy of oscillometric blood pressure monitoring in Management of primary postpartum haemorrhage pregnancy and pre-eclampsia 350 J. Drife M. Gupta, A. H. Shennan, A. Halligan, D. J. Taylor & M. de Swiet xiv CONTENTS Can 24-hour ambulatory blood pressure measurement predict Abortion after 24 weeks the development of hypertension in primigravidae? D. Paintin J. R. Higgins, J. J. Walshe, A. Halligan, E. O’Brien, R. Conroy & M. R. N. Darling REVIEW Maternal fever in term labour in relation to fetal tachycardia, Adhesion molecules in reproduction cord artery acidaemia and neonatal infection L. D. Klentzeris A. Herbst, P. Wélner-Hanssen & I. Ingemarsson Maternal serum inhibin-A and free b-hCG concentrations in OBSTETRICS trisomy 21 pregnancies at 10 to 14 weeks of gestation The Stockholm Birth Centre Trial: maternal and infant outcome P. L. Noble, E. M. Wallace, R. J. M. Snijders, U. Waldenstrém, C.-A. Nilsson & B. Winbladh N. P. Groome & K. H. Nicolaides A randomised controlled trial of Doppler ultrasound SURGICAL TECHNIQUES velocimetry of the umbilical artery in low risk pregnancies The B-Lynch surgical technique for the control of massive Doppler French Study Group postpartum haemorrhage: an alternative to hysterectomy? Umbilical artery Doppler velocimetry in unselected and Five cases reported low risk pregnancies: a review of randomised controlled trials C. B-Lynch, A. Coker, A. H. Lawal, J. Abu & M. J. Cowen F. Goffinet, J. Paris-Llado, I. Nisand & G. Bréart Randomised controlled trial of cardiotocography versus SHORT COMMUNICATION umbilical artery Doppler in the management of small for Clinical effect of meso-tetrahydroxyphenylchlorine based gestational age fetuses photodynamic therapy in recurrent carcinoma of the ovary: J. Haley, D. J. Tuffnell & N. Johnson preliminary results F. Wierrani, D. Fiedler, W. Grin, M. Henry, E. Dienes, K. The diagnostic accuracy of cervico-vaginal fetal fibronectin in Gharehbaghi, B. Krammer & W. Griinberger predicting preterm delivery: an overview P. F- W. Chien, K. S. Khan, S. Ogston & P. Owen CASE REPORT Fetal size and growth velocity in the prediction of intrapartum Migration of a Filshie clip into the urinary bladder seven years caesarean section for fetal distress after laparoscopic sterilisation P. Owen, A. J. Harrold & T. Farrell G. J. Kesby & A. R. Korda A meta-analysis of low dose aspirin for the prevention of intrauterine growth retardation CORRESPONDENCE H. Leitich, C. Egarter, P. Husslein, A. Kaider & M. Schemper Transvaginal ultrasound in the management of women with suspected cervical incompetence (Vol 103, September 1996) MATERNAL-FETAL MEDICINE R. D. Macdonald, P. A. Smith & S. K. Vyas; M. Quinn The effect of carotid sinus denervation on fetal heart rate The case against new reproductive technologies in developing variation in normoxia, hypoxia and post-hypoxia in fetal sheep 460 countries (Vol 103, October 1996) S. Kozuma, T. Watanabe, L. Bennet, T. C. Harry L. R. Green & M. A. Hanson Protective effect of depot-medroxyprogesterone acetate on Increased levels of intercellular adhesion molecules and vascular surgically treated uterine leiomyomas: a multicentre cell adhesion molecules in pre-eclampsia 466 case-control study (Vol 103, September 1996) S. Djurovic, R. Schjetlein, F: Wisloff; G. Haugen & K. Berg A. A. Ikomi & A. Singer REPRODUCTIVE MEDICINE Volume 104 Number4 April 1997 Effects of SR 49059, an orally active V 1a vasopressin receptor antagonist, on vasopressin-induced uterine contractions EDITOR’S CHOICE T. Bossmar, R. Brouard, A. Déberl & M. Akerlund VIEWPOINT Evidence-based audit? GYNAECOLOGY J. O. Drife Late termination of pregnancy in North Holland J. M. Bosma, G. van der Wal & S. L. Hosman-Benjaminse EDITORIAL Experience of Finnish women with Norplant insertions and The whole duty of obstetricians removals J. M. Grant E. Ollila, S. Sihvo, J. Merildinen & E. Hemminki COMMENTARIES SHORT COMMUNICATIONS Umbilical artery Doppler—more harm than good? J.C. P. Kingdom, C. H. Rodeck & P. Kaufmann Bradykinin stimulates interleukin-6 and interleukin-8 secretion of human decidua derived cells 495 Midwife-led care J. Rehbock, A. Chondromatidou, P. Buchinger, W. J. Graham A. Hermann & M. Jochum CONTENTS Interleukin-8 in urine: a new diagnostic parameter for intra- Elevated levels of serum nitrate, a stable end product of nitric amniotic infection after premature rupture of the membranes 499 oxide, in women with pre-eclampsia 538 B. Stiemer, A. Buschmann, S. Bisson, K. Hensel, A. K. Smarason, K. G. Allman, D. Young & C. W. G. Redman H.-J. Gramm, H. Hopp & H.-K. Weitzel OBSTETRICS CASE REPORTS External cephalic version at term: a survey of consultant obstetric Prenatally detected reversal of donor—recipient roles in practice in the United Kingdom and Republic of Ireland 544 twin-to-twin transfusion syndrome following in utero treatment 503 T. Coltart, D. K. Edmonds & R. Al-Mufti G. Mielke, R. Mayer, H. Franz, M. Gonser & K. Marzusch Early amniotomy increases the frequency of fetal heart rate Perineal delivery in Ehlers—Danlos syndrome 505 abnormalities M. S. Georgy, K. Anwar, S. E. Oates & D. H. A. Redford F- Goffinet, W. Fraser, S. Marcoux, G. Bréart, J.-M. Moutquin, M. Daris & the Amniotomy Study Group CORRESPONDENCE Blood pressure and fetal heart rate changes with patient-controlled combined spinal epidural analgesia while ambulating inlabour 554 Medico-—legal aspects of ureteric damage during abdominal hysterectomy (Vol 103, December 1996) R. Al-Mufti, R. Morey, A. Shennan & B. Morgan J. Blandy, J. C. Smith & V. Tindall;C. Nzewi & S. Emery Automated blood pressure measurement as a predictor of proteinuric pre-eclampsia 559 Correspondence. Choice and instrumental delivery (Vol 103, December 1996) A. W. F: Halligan, A. Shennan, P. C. Lambert, S. C. Bell, D. J. Taylor & M. de Swiet D. J. Tuffnell & A. Wright Third degree obstetric perineal tears: risk factors and the preventive Persistent ectopic pregnancy following conservative surgery role of mediolateral episiotomy 563 for tubal pregnancy (Vol 103, October 1996) 508 A. Apoola;A. K. As & D. M. Jaja;R. Hart & A. Magos A. C. Poen, R. J. F. Felt-Bersma, G. A. Dekker, W. Devillé, M. A. Cuesta & S. G. M. Meuwissen Blood pressure measurement in pregnancy (Vol 103, September 1996) EPIDEMIOLOGY M. Quinn Randomised trial comparing the upright and supine positions Anew method for measuring menstrual blood loss and its use in for the second stage of labour screening women before endometrial ablation P. R. de Jong, R. B. Johanson, P. Baxen, V. D. Adrians, (Vol 103, October 1996) S. van der Westhuisen & P. W. Jones P. O'Brien Influence of hypertensive disorders and cigarette smoking on placental abruption and uterine bleeding during pregnancy C. V. Ananth, D. A. Savitz, W. A. Bowes Jr & E. R. Luther Volume 104 Number 5 May 1997 Epidemiology of genital prolapse: observations from the Oxford Family Planning Association study J. Mant, R. Painter & M. Vessey EDITOR’S CHOICE FIGO ONCOLOGY FIGO Committee for the Study of Ethical Aspects of The case for stopping cervical screening at age 50 Human Reproduction M. E. Cruickshank, V. Angus, M. Kelly, S. McPhee & H. C. Kitchener COMMENTARIES Randomised trial of immediate versus deferred treatment Laparoscopic excision of endometriosis: the treatment of choice? 513 strategies for the management of minor cervical R. Garry cytological abnormalities Do different brands of oral contraceptives differ in their effects M. I. Shafi, D. M. Luesley, J. A. Jordan, J. A. Dunn, on cardiovascular disease? 516 T. P. Rollason & M. Yates D. Crook GYNAECOLOGY REVIEWS Complications of laparoscopy: a prospective multicentre observational study Assisted conception following poor ovarian response to F. W. Jansen, K. Kapiteyn, T. Trimbos-Kemper, gonadotrophin stimulation J. Hermans & J. B. Trimbos S. D. Keay, N. H. Liversedge, R. S. Mathur & J. M. Jenkins A pragmatic randomised comparison of transcervical resection Domestic violence and pregnancy of the endometrium with endometrial laser ablation for the G. C. Mezey & S. Bewley treatment of menorrhagia S. Bhattacharya, I. M. Cameron, D. E. Parkin, MATERNAL-FETAL MEDICINE D. R. Abramovich, J. Mollison, S. B. Pinion, D. A. Alexander, A. Grant & H. C. Kitchener The effect of nifedipine and methyldopa on maternal cerebral circulation Radiofrequency induced endometrial ablation: an update V. Serra-Serra, P. M. Kyle, R. Chandran & C. W. G. Redman R. F. A. Thijssen xvi CONTENTS The levonorgestrel intrauterine system in the management of COMMENTARIES menorrhagia What should obstetricians be doing about the Barker hypothesis? 645 J. W. Barrington & P. Bowen-Simpkins R. Fraser & J. Cresswell Female victims of rape and their genital injuries Customised fetal growth assessment 648 L. Bowyer & M. E. Dalton , S. Leeson & N. Aziz SURGICAL TECHNIQUES REVIEW Vaginal endoscopic oophorectomy with vaginal hysterectomy: a simple minimal access surgery technique 621 Hypoxia-ischaemia and the developing brain: hypotheses regarding the pathophysiology of fetal—neonatal brain damage M. A. Hefni & A. E. Davies L. D. Longo & S. Packianathan SHORT COMMUNICATION Ploidy profile of morphologically normal squamous epithelium EPIDEMIOLOGY adjacent to high grade cervical intraepithelial neoplasia 623 Maternal birthweight and diet in pregnancy in relation to the N. McDermott, Y. Suliman, C. B. Walsh, E. W. Kay, infant’s thinness at birth B. Curran, C. Milburn, M. Turner, W. Prendiville & M. Leader K. M. Godfrey, D. J. P. Barker, S. Robinson & C. Osmond CASE REPORTS Significance of low birthweight for gestational age among very preterm infants Selective termination by intrahepatic vein alcohol injection ofa A. Spinillo, E. Capuzzo, G. Piazzi, F: Baltaro, monochorionic twin pregnancy discordant for fetal abnormality M. Stronati & A. Ometto M. L. Denbow, M. R. Battin, P. M. Kyle, R. Fogliani, P. Johnson & N. M. Fisk MATERNAL-—FETAL MEDICINE Successful methotrexate treatment of a viable pregnancy within a thin uterine scar Transvaginal Doppler ultrasound of the uteroplacental circulation in the early prediction of pre-eclampsia and A. Ravhon, A. Ben-Chetrit, R. Rabinowitz, intrauterine growth retardation M. Neuman & U. Beller K. Harrington, R. G. Carpenter, C. Goldfrad & S. Campbell Familial puerperal alactogenesis: possibility ofa genetically transmitted isolated prolactin deficiency 24-hour blood pressure monitoring to evaluate the effects of A. H. Zargar, S. R. Masoodi, B. A. Laway, nifedipine in pre-eclampsia and in chronic hypertension in N. A. Shah & M. Salahudin pregnancy C. Benedetto, M. Zonca, M. Giarola, V. Maula, L. Chiarolini & F- Carandente BLAIR BELL RESEARCH SOCIETY Papers presented at the meeting held in Liverpool, 4 October 1996 OBSTETRICS Antioxidants in the treatment of severe pre-eclampsia: CORRESPONDENCE an explanatory randomised controlled trial A prospective study to evaluate oophorectomy at the time of A. M. Giilmezoglu, G. J. Hofmeyr& M. M. J. Oosthuisen vaginal hysterectomy (Vol 103, September 1996) A single cervical fetal fibronectin screening test in a population R. Garry, M. Whittaker & G. Phillips at low risk for preterm delivery: an improvement on clinical indicators? Correspondence. Magnesium sulphate: the time for reckoning (Vol 103, August 1996) 642 G. Faron, M. Boulvain, J.-P. Lescrainier & A. Vokaer T. O. Idama & S. W. Lindow Lack of analgesic effect of systemically administered morphine or GYNAECOLOGY pethidine on labour pain (Vol 103, October 1996) 643 Effects on bone mass after eight years of hormonal M. J. Lucas, S. M. Ramin & S. Sharma replacement therapy A prospective cohort study of oxytocin plus ergometrine P. Eiken, S. Pors Nielsen & N. Kolthoff compared with oxytocin alone for prevention of postpartum Long term influence of different postmenopausal hormone haemorrhage (Vol 103, November 1996) 643 replacement regimens on serum lipids and lipoprotein(a): P. M. Yuen a randomised study Oral versus vaginal misoprostol for cervical priming W. Hanggi, K. Lippuner, W. Riesen, (Vol 103, November 1996) P. Jaeger & M. H. Birkhauser S. Barik & P. Stewart ONCOLOGY A studyo f treatment failures following large loop excision of the transformation zone for the treatment of cervical intraepithelial Volume 104 Number6 June 1997 neoplasia G. Flannelly, H. Langhan, L. Jandial, E. Mann, EDITOR’S CHOICE M. Campbell & H. Kitchener CONTENTS Xvii Simultaneous effects of aneuploidy and oncogenic human Antenatal testing for HIV: to opt in or opt out, that is the question papillomavirus on histological grade of cervical (Vol 103, November 1996) 758 intraepithelial neoplasia 723 S. E. MacDonagh, D. Mercey, J. Kennedy & M. Blott J. Monsonego, P. Valensi, L. Zerat, C. Clavel & P. Birembaut Protective effect of depot-medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre SHORT COMMUNICATIONS case-control study (Vol 103, September 1996) 758 The effect of long term oestradiol implantation on bone mineral K. Bassaw & K. Gangar density in postmenopausal women who have undergone hysterectomy and bilateral oophorectomy 728 Doctors leaving the training grades in obstetrics and gynaecology: a study of the years 1985 to 1988 (Vol 103, December 1996) 759 M. Wahab, P. Ballard, D. W. Purdie, A. Cooper& J. C. Willson L. Skillern Urinary tract injuries during obstetric intervention 731 Early prediction of pre-eclampsia by measurement of kallikrein D. Rajasekar & M. Hall and creatinine on a random urine sample (Vol 103, May 1996) 759 Routine antenatal screening for syphilis in Lothian: a study of P. Stratta, C. Canavese, G. Piccoli, T. Todros & C. Benedetto the results 1988 to 1994 Borderline ovarian cancer, bilateral surgical castration, S. T. Cameron, K. J. Thong, H. Young & W. A. Liston chemotherapy and a normal delivery after ovum donation and Comparison of second trimester biometry in singleton and twin in vitro fertilisation—embryo transfer (Vol 103, September 1996) 760 pregnancies conceived with assisted reproductive techniques S. El-Sharkawi & P. Bowen-Simpkins J. Gardosi, T. Mul, A. Francis, J. Hall & S. Fishel BOOK REVIEWS Maternal serum free b-hCG at 10 to 14 weeks of gestation in trisomic twin pregnancies P. L. Noble, R. J. M. Snijders, H. D. Abraha, R. A. Sherwood & K. H. Nicolaides Volume 104 Number 7 July 1997 Indicators of platelet turnover in thrombocytopenic infants A. C. Sciscione, H. Bessos, N. Callan, EDITOR’S CHOICE K. Blakemore & T. Kickler COMMENTARIES Randomised controlled trials in perinatal medicine: |. CASE REPORTS The need for studies of mortality and major morbidity with adequate power Churg-Strauss disease: deterioration in a twin pregnancy. Successful outcome following treatment with corticosteroids and W. Tarnow-Mordi & P. Brocklehurst cyclophosphamide 746 Randomised controlled trials in perinatal medicine: 2. C. Barry, S. Davis, P. Garrard & I. T. Ferguson Recruitment ofa pregnant woman or her newborn child into more than one trial Uterine carcinosarcoma in association with tamoxifen therapy 748 P. Brocklehurst W. G. McCluggage, D. T. McManus, T. F- Lioe & C. M. Hill Randomised controlled trials in perinatal medicine: 3. Survival of intrauterine twins and an interstitial singleton fetus Identifying and measuring endpoints in randomised from a heterotopic in vitro fertilisation-embryo controlled trials transfer pregnancy A. Johnson M. J. M. Luckas, K. Fishwick, M. Martin-Hierro, G. C. Shaw & S. A. Walkinshaw Obstetric intervention and benefit in conditions of very low prevalence Missed abortion versus delayed miscarriage M. Mongelli, T. K. H. Chung & A. M. Z. Chang D. J. Hutchon OBSTETRICS CORRESPONDENCE Recombinant human relaxin as a cervical ripening agent Medico-—legal aspects of ureteric damage during abdominal J. E. Brennand, A. A. Calder, C. R. Leitch, I. A. Greer, hysterectomy (Vol 103, December 1996) M. M. Chou & I. Z. MacKenzie D. E. P. Shapland Routine oxytocin in the third stage of labour: a placebo Anal and urinary incontinence in women with obstetric anal controlled randomised trial sphincter rupture (Vol 103, October 1996) L. Nordstrém, K. Fogelstam, G. Fridman, A. Larsson & H. A. Malik, N. Fenning & E. O'Donnell; Rydhstroem A. H. Sultan & A. K. Monga Antenatal perineal massage and subsequent perineal outcomes: Using a logistic model to identify women with a randomised controlled trial 787 first-trimester spontaneous abortion suitable for M. K. Shipman, D. R. Boniface, M. E. Tefft & F: McCloghry expectant management (Vol 103, December 1996) Gestational age and induction of labour for prolonged pregnancy 792 D. G. Tincello, R. G. Farquharson & D. G. Wilkinson J. Gardosi, T. Vanner& A. Francis Magnesium sulphate in the treatment of eclampsia and pre-eclampsia: an overview of the evidence from Predictors of successful external cephalic version at term: randomised trials (Vol 103, November 1996) a prospective study L. Duley & J. Neilson T. K. Lau, K. W. K. Lo, D. Wan & M. S. Rogers XVili CONTENTS The obstetric experience of carriers of haemophilia BLAIR BELL RESEARCH SOCIETY R. A. Kadir, D. L. Economides, J. Braithwaite, Papers presented at the Royal College of Obstetricians and E. Goldman & C. A. Lee Gynaecologists, London, February 1997 MATERNAL-FETAL MEDICINE CORRESPONDENCE Screening for Down’s syndrome: changes in marker levels and Treatment of large uterine fibroids (Vol 103, June 1996) detection rates between first and second trimesters R. Chapman; A. Magos E. Berry, D. A. Aitken, J. A. Crossley, Recurrent Stage IB cervical carcinoma: evaluation of the J. N. Macri & J. M. Connor effectiveness of routine follow up surveillance The disappearance of fetal and donor red blood cells in (Vol 103, November 1996) alloimmunised pregnancies: a reappraisal C. A. McKenzie J. Egberts, I. L. van Kamp, H. H. H. Kanhai, R. H. Meerman, The management of cervical carcinoma within the South West P. C. Giordano & J. Bennebroek Gravenhorst Region of England (Vol 104, February 1997) Circadian rhythm of frequency-domain measures of heart rate J. B. Murdoch variability in pregnancy E. M. K. Ekholm, J. Hartiala & H. V. Huikuri The management of endometrial cancer (Vol 104, February 1997) L. Rogerson & E. Downes GYNAECOLOGY Preventing Rhesus D haemolytic disease of the newborn by Medical abortion or vacuum aspiration? Two year follow up of giving anti-D immunoglobulin: are the guidelines being a patient preference trial adequately followed? (Vol 104, January 1997) F. L. Howie, R. C. Henshaw, S. A. Naji, K. Harding I. T. Russell & A. A. Templeton Faecal incontinence after childbirth (Vol 104, January 1997) Is conservative surgery for tubal pregnancy preferable to salpingectomy? An economic analysis K. Marshall, D. M. Walsh & D. Baxter B. W. J. Mol, P. J. Hajenius, S. Engelsbel, W. M. Ankum, The mythology of hormone replacement therapy D. J. Hemrika, F- van der Veen & P. M. M. Bossuyt (Vol 104, February 1997) K. A. J. Chin SHORT COMMUNICATIONS Impact of new methods on therapeutic abortion at the Royal Randomised trial of expectant versus surgical management of Infirmary of Edinburgh (Vol 103, December 1996) spontaneous miscarriage P. Stewari, P. Slade & J. Fletcher J. Chipchase & D. James Randomised placebo controlled trial of mefenamic acid for BOOK REVIEWS premedication at outpatient hysteroscopy: a pilot study F. Nagele, G. Lockwood & A. L. Magos The Kleihauer Technique: an accurate method of quantifying fetomaternal haemorrhage? Volume 104 Number 8 August 1997 J. R. A. Duckett & G. Constantine The prevalence and consequences of missed abortion in twin pregnancies at 10 to 14 weeks of gestation EDITOR’S CHOICE COMMENTARIES N. J. Sebire, S. Thornton, K. Hughes, R. J. M. Snijders & K. H. Nicolaides Achieving best practice in maternity care Maternal serum alpha-fetoprotein in fetal neural tube and A. W. F. Halligan, D. J. Taylor, N. J. Naftalin, P. M. Homa & B. J. Crump abdominal wall defects at 10 to 14 weeks of gestation N. J. Sebire, K. Spencer, P. L. Noble, Perinatal audit in Europe K. Hughes & K. H. Nicolaides P. M. Dunn Dexamethasone-induced leucocytosis in pregnancy Has screening for cervical cancer been successful? F.C. Denison, C. L. Elliott& E. M. Wallace J. Patnick Who understands the menopause? CASE REPORTS D. H. Barlow Acquired haemophilia, an unusual cause of severe postpartum haemorrhage REVIEWS R. A. Kadir, M. B. Koh, C. A. Lee & K. J. Pasi Management of fetal choroid plexus cysts Posterior uterine rupture in a patient with a lower segment J. K. Gupta, K. S. Khan, J. G. Thornton & R. J. Lilford caesarean section scar complicating prostaglandin induction of labour The HELLP syndrome J. A. Hawe & K. S. Olah M. Geary

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